MX2022013224A - Sintesis de un inhibidor de la monoacilglicerol lipasa. - Google Patents

Sintesis de un inhibidor de la monoacilglicerol lipasa.

Info

Publication number
MX2022013224A
MX2022013224A MX2022013224A MX2022013224A MX2022013224A MX 2022013224 A MX2022013224 A MX 2022013224A MX 2022013224 A MX2022013224 A MX 2022013224A MX 2022013224 A MX2022013224 A MX 2022013224A MX 2022013224 A MX2022013224 A MX 2022013224A
Authority
MX
Mexico
Prior art keywords
synthesis
lipase inhibitor
monoacylglycerol lipase
monoacylglycerol
inhibitor
Prior art date
Application number
MX2022013224A
Other languages
English (en)
Inventor
Cheryl A Grice
Todd K Jones
Kurt G Grimm
Giuseppe Guercio
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of MX2022013224A publication Critical patent/MX2022013224A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023—Preparation; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

En la presente se describe la fabricación del inhibidor de MAGL 4-(2-(pirrolidin-1-il)-4-(trifluorometil)bencil)piperazin-1-carbo xilato de 1,1,1,3,3,3-hexafluoropropan-2-ilo, incluidas las sales de este.
MX2022013224A 2020-04-21 2021-04-19 Sintesis de un inhibidor de la monoacilglicerol lipasa. MX2022013224A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063013454P 2020-04-21 2020-04-21
PCT/IB2021/000277 WO2021214550A1 (en) 2020-04-21 2021-04-19 Synthesis of a monoacylglycerol lipase inhibitor

Publications (1)

Publication Number Publication Date
MX2022013224A true MX2022013224A (es) 2022-11-14

Family

ID=76355536

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022013224A MX2022013224A (es) 2020-04-21 2021-04-19 Sintesis de un inhibidor de la monoacilglicerol lipasa.

Country Status (15)

Country Link
US (2) US11702393B2 (es)
EP (1) EP4139288A1 (es)
JP (1) JP2023523219A (es)
KR (1) KR20230004622A (es)
CN (1) CN115427403A (es)
AR (1) AR121899A1 (es)
AU (1) AU2021259496A1 (es)
BR (1) BR112021025516A2 (es)
CA (1) CA3175210A1 (es)
CL (1) CL2022002895A1 (es)
IL (1) IL297470A (es)
MX (1) MX2022013224A (es)
TW (1) TW202200564A (es)
WO (1) WO2021214550A1 (es)
ZA (1) ZA202211124B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104159581B (zh) 2012-01-06 2017-09-01 阿比德治疗公司 氨基甲酸酯化合物及其制备和使用方法
AU2021259496A1 (en) 2020-04-21 2022-11-10 H. Lundbeck A/S Synthesis of a monoacylglycerol lipase inhibitor

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Also Published As

Publication number Publication date
JP2023523219A (ja) 2023-06-02
BR112021025516A2 (pt) 2022-11-01
AU2021259496A1 (en) 2022-11-10
KR20230004622A (ko) 2023-01-06
AR121899A1 (es) 2022-07-20
US20240158360A1 (en) 2024-05-16
EP4139288A1 (en) 2023-03-01
US11702393B2 (en) 2023-07-18
CN115427403A (zh) 2022-12-02
CL2022002895A1 (es) 2023-04-21
WO2021214550A1 (en) 2021-10-28
US20210323938A1 (en) 2021-10-21
IL297470A (en) 2022-12-01
CA3175210A1 (en) 2021-10-28
TW202200564A (zh) 2022-01-01
ZA202211124B (en) 2024-02-28

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