BRPI0519343A2 - piperazinil e piperidinil urÉias e compostos relacionados como moduladores de hidrolase de amida de Ácido graxo para o tratamento de ansiedade, dor e outras condiÇÕes - Google Patents

piperazinil e piperidinil urÉias e compostos relacionados como moduladores de hidrolase de amida de Ácido graxo para o tratamento de ansiedade, dor e outras condiÇÕes

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Publication number
BRPI0519343A2
BRPI0519343A2 BRPI0519343-5A BRPI0519343A BRPI0519343A2 BR PI0519343 A2 BRPI0519343 A2 BR PI0519343A2 BR PI0519343 A BRPI0519343 A BR PI0519343A BR PI0519343 A2 BRPI0519343 A2 BR PI0519343A2
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BR
Brazil
Prior art keywords
alkyl
anxiety
pain
fatty acid
acid amide
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Application number
BRPI0519343-5A
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English (en)
Inventor
Richard Apodaca
James Guy Breitenbucher
Kanaka Pattabiraman
Mark Seierstad
Wei Xiao
Original Assignee
Janssen Pharmaceutica Nv
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0519343A2 publication Critical patent/BRPI0519343A2/pt

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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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Abstract

PIPERAZINIL E PIPERIDINIL URÉIAS E COMPOSTOS RELACIONADOS COMO MODULADORES DE HIDROLASE DE AMIDA DE ÁCIDO GRAXO PARA O TRATAMENTO DE ANSIEDADE, DOR E OUTRAS CONDIÇÕES. A presente invenção refere-se a compostos de fórmula (1) usados como inibidores de FAAH, em que Z é -N- ou >CH; R¹ é -H ou -C~ 1-4~ alquila; Ar¹ é 2-tiazolila, 2-piridila, 3-piridila, 4-piridila, 2-pirimidinila, 4- pirimidinila, 5-pirimidinhla ou fenila, cada uma não substituida ou substituida, em um elemento do anel de carbono, por uma ou duas porções R^ a^; na qual cada porção R^ a^ é independentemente selecionada do grupo consistindo em -C~ 1-4~ alquila, -C~ 2-4~ alquenila, -OH, -0C~ 1-4~ alquila, halo, -CF~ 3~, -OCF~ 3~, -SCF~ 3~, -SH, -S(O)~0-2~C~ 1-4~ alquila, -0S0~ 2~C~ 1-4~ alquila, -C0~ 2~C~ 1-4~ alquila, -CO~ 2~H, -COC~ 1-4~ alquila, -N(R^ b^)R^ c^, -SO~ 2~NR^ b^R^ c^, -NR^ b^SO~ 2~R^ c^, -C(=O)NR^ b^R^ c^, -NO^ 2^ e -CN, em que R^ b^ e R^ c^ são, cada um, independentemente -H ou -C~ 1-4~ alquila; e Ar² é como definido nas reivindicações. Tais compostos podem ser usados em composições farmacêuticas e métodos para o tratamento de estado de doença, distúrbios e condições mediadas por atividade hidrolase de amidas de ácido graxo (FAAH). Deste modo, os compostos podem ser administrados pra tratar, por exemplo, ansiedade, dor, inflamação, distúrbios do sono, distúrbios de alimentação ou distúrbios do movimento (tal como, esclerose múltipla).
BRPI0519343-5A 2004-12-30 2005-12-29 piperazinil e piperidinil urÉias e compostos relacionados como moduladores de hidrolase de amida de Ácido graxo para o tratamento de ansiedade, dor e outras condiÇÕes BRPI0519343A2 (pt)

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PCT/US2005/047329 WO2006074025A1 (en) 2004-12-30 2005-12-29 Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase

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Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200633990A (en) * 2004-11-18 2006-10-01 Takeda Pharmaceuticals Co Amide compound
SI1836179T1 (sl) * 2004-12-30 2015-07-31 Janssen Pharmaceutica N.V. Amidni derivati piperidin- in piperazin-1-karboksilne kisline in sorodne spojine kot modulatorji maščobnokislinske amidne hidrolaze (faah) za zdravljenje tesnobe, bolečine in drugih stanj
GB0503056D0 (en) * 2005-02-14 2005-03-23 Smithkline Beecham Corp Chemical compounds
PE20070099A1 (es) * 2005-06-30 2007-02-06 Janssen Pharmaceutica Nv N-heteroarilpiperazinil ureas como moduladores de la amida hidrolasa del acido graso
WO2007020888A1 (ja) * 2005-08-12 2007-02-22 Takeda Pharmaceutical Company Limited 脳・神経細胞保護剤および睡眠障害治療薬
WO2007086584A1 (ja) * 2006-01-30 2007-08-02 Meiji Seika Kaisha, Ltd. 新規ＦａｂＫおよびＦａｂＩ／Ｋ阻害剤
ITRM20060090A1 (it) * 2006-02-22 2007-08-23 Sigma Tau Ind Farmaceuti Nuovi composti inibitori cpt a livello del snc come farmaci antidiabetici e o antiobesita
EP2023728A4 (en) * 2006-05-26 2010-11-24 Janssen Pharmaceutica Nv OXAZOLYLPIPERIDINES AS MODULATORS OF FATTY ACID AMIDHYDROLASE
CA2665804A1 (en) 2006-08-23 2008-02-28 Astellas Pharma Inc. Urea compound or salt thereof
ES2357340T3 (es) 2006-10-18 2011-04-25 Pfizer Products Inc. Compuestos de biaril éter urea.
RU2009148304A (ru) * 2007-05-25 2011-06-27 Янссен Фармацевтика Н.В. (Be) Модуляторы гидролазы амидов жирных кислот на основе гетероарилзамещенной мочевины
WO2009105220A1 (en) * 2008-02-19 2009-08-27 Janssen Pharmaceutica N.V. Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase
EP2276738A1 (en) * 2008-04-17 2011-01-26 Pfizer Inc. Ether benzylidene piperidine 5-membered aryl carboxamide compounds useful as faah inhibitors
US20110060012A1 (en) * 2008-04-17 2011-03-10 Pfizer Inc. 4-[3-(aryloxy)benzylidene]-3-methyl piperidine 5-membered aryl carboxamide compounds useful as faah inhibitors
WO2009127949A1 (en) * 2008-04-17 2009-10-22 Pfizer Inc. 4- [3- (aryloxy) benzylidene] -3-methyl piperidine aryl carboxamide compounds useful as faah inhibitors
JP2011518143A (ja) * 2008-04-17 2011-06-23 ファイザー・インク Ｆａａｈ阻害剤として有用なエーテルベンジリデンピペリジンアリールカルボキサミド化合物
CA2719789A1 (en) * 2008-04-17 2009-10-22 Pfizer Inc. 4-benzylidene-3-methylpiperidine aryl carboxamide compounds useful as faah inhibitors
US8080566B1 (en) 2008-06-11 2011-12-20 Kalypsys, Inc Carbazole inhibitors of histamine receptors for the treatment of disease
US20100113465A1 (en) * 2008-10-30 2010-05-06 Pfizer Inc. 7-azaspiro[3.5]nonane-7-carboxamide compounds
CA2741839A1 (en) * 2008-11-21 2010-05-27 Pfizer Inc. 1-oxa-8-azaspiro [4,5] decane-8-carboxamide compounds as faah inhibitors
WO2010068453A1 (en) * 2008-11-25 2010-06-17 Janssen Pharmaceutica Nv Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
WO2010068452A1 (en) 2008-11-25 2010-06-17 Janssen Pharmaceutica Nv Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
TWI469979B (zh) * 2008-12-24 2015-01-21 Bial Portela & Ca Sa 脂肪酸醯胺水解酶(faah)抑制劑、以及其藥學組成物與用途
US20120083476A1 (en) 2009-06-05 2012-04-05 Janssen Pharmaceutica Nv Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase
US8901111B2 (en) 2009-06-05 2014-12-02 Janssen Pharmaceutica Nv Aryl-substituted heterocyclic urea modulators of fatty acid amide hydrolase
WO2011022348A1 (en) 2009-08-18 2011-02-24 Janssen Pharmaceutica Nv Ethylene diamine modulators of fatty acid amide hydrolase
WO2011060026A1 (en) 2009-11-12 2011-05-19 Jansen Pharmaceutica Nv Piperazinecarboxamide derivative useful as a modulator of fatty acid amide hydrolase (faah)
WO2011071995A2 (en) 2009-12-08 2011-06-16 Case Western Reserve University Compounds and methods of treating ocular disorders
EP2518064A1 (en) 2009-12-25 2012-10-31 Mochida Pharmaceutical Co., Ltd. Novel aryl urea derivative
WO2011085216A2 (en) 2010-01-08 2011-07-14 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating parkinson's disease and restless legs syndrome
US20130030000A1 (en) * 2010-01-28 2013-01-31 Chobanian Harry R Pharmaceutical compositions for the treatment of pain and other indications
US20130224151A1 (en) 2010-03-31 2013-08-29 United States Of America Use of FAAH Inhibitors for Treating Abdominal, Visceral and Pelvic Pain
UA108233C2 (uk) 2010-05-03 2015-04-10 Модулятори активності гідролази амідів жирних кислот
AU2012311061B2 (en) 2011-09-23 2016-08-18 Advinus Therapeutics Limited Amide compounds, compositions and applications thereof
PT2800565T (pt) 2012-01-06 2020-04-29 Scripps Research Inst Compostos de carbamato e processos para a sua preparação e utilização
WO2013170072A2 (en) * 2012-05-09 2013-11-14 Neurop, Inc. Compounds for the treatment of neurological disorders
CN104582794A (zh) * 2012-08-31 2015-04-29 诺瓦药品公司 用于治疗病毒性疾病的杂环基氨甲酰
US20150376198A1 (en) * 2013-02-18 2015-12-31 The Scripps Research Institute Modulators of vasopressin receptors with therapeutic potential
WO2014179144A1 (en) * 2013-04-29 2014-11-06 E. I. Du Pont De Nemours And Company Fungicidal heterocyclic compounds
CN105793247B (zh) * 2013-07-24 2018-03-16 比亚尔-珀特拉和Ca股份公司 咪唑甲酰胺类及其作为faah抑制剂的用途
US10100027B2 (en) 2014-09-26 2018-10-16 Changzhou Yinsheng Pharmaceutical Co., Ltd. Benzofuran analogue as NS4B inhibitor
US10758525B2 (en) 2015-01-22 2020-09-01 MyoKardia, Inc. 4-methylsulfonyl-substituted piperidine urea compounds
CA2979537C (en) * 2015-03-18 2023-08-29 Abide Therapeutics, Inc. Piperazine carbamates and methods of making and using same
US10463753B2 (en) 2016-02-19 2019-11-05 Lundbeck La Jolla Research Center, Inc. Radiolabeled monoacylglycerol lipase occupancy probe
CN109661392A (zh) * 2016-06-30 2019-04-19 巴斯利尔药物国际股份公司 用于治疗增殖性障碍的线粒体抑制剂
WO2018053447A1 (en) 2016-09-19 2018-03-22 Abide Therapeutics, Inc. Piperazine carbamates and methods of making and using same
MA46589A (fr) 2016-10-24 2019-08-28 Yumanity Therapeutics Inc Composés et utilisations de ces derniers
JOP20190105A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
JOP20190106A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
US10364245B2 (en) 2017-06-07 2019-07-30 Chiesi Farmaceutici S.P.A. Kinase inhibitors
TW201927302A (zh) * 2017-10-12 2019-07-16 瑞士商巴塞利亞藥業國際股份有限公司 用於治療增殖障礙之線粒體抑制劑
CA3083000A1 (en) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Compounds and uses thereof
JP7346425B2 (ja) 2018-01-11 2023-09-19 セントラス セラピューティクス 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤
CR20200545A (es) 2018-05-15 2020-12-17 Lundbeck La Jolla Research Center Inc Inhibidores magl
EP3793552B1 (en) 2018-05-15 2023-07-12 The Scripps Research Institute Abhd12 inhibitors and methods of making and using same
CN110878070B (zh) * 2018-09-06 2021-08-31 中国科学院化学研究所 一种制备不对称脲类化合物的方法
WO2020232153A1 (en) * 2019-05-14 2020-11-19 Lundbeck La Jolla Research Center, Inc. Abhd12 inhibitors and methods of making and using same
MX2022013224A (es) 2020-04-21 2022-11-14 H Lundbeck As Sintesis de un inhibidor de la monoacilglicerol lipasa.
EP4163273A1 (en) 2021-10-07 2023-04-12 Universita' Degli Studi Di Pavia Substituted vinyl piperazine-piperidine urea derivatives as anticancer agents
CN114605385B (zh) * 2022-03-25 2023-09-08 河南大学 吲哚哌啶脲类trpv1拮抗/faah抑制双靶点药物及制备方法和应用
WO2024059333A1 (en) * 2022-09-16 2024-03-21 Ohio State Innovation Foundation Compounds for treating infections with parasitic protozoa

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1292410A (en) 1970-05-13 1972-10-11 Yoshitomi Pharmaceutical Thienobenzothiazepine derivatives
JPS5347725Y2 (pt) 1971-06-18 1978-11-15
JPS5515456A (en) * 1978-07-19 1980-02-02 Morishita Seiyaku Kk 2-substituted-piperazinomethyl-1,4-benzodioxane
NZ223847A (en) 1987-04-01 1989-12-21 Janssen Pharmaceutica Nv Substituted piperazine derivatives and pharmaceutical compositions
JPH07502014A (ja) 1991-06-21 1995-03-02 ベーリンガー　マンハイム　イタリア　エス．ピー．エイ． 気道に対して抗喘息性、抗炎症性活性を有する２−アミノ−４−アリール−チアゾール
JPH0810160A (ja) 1994-06-28 1996-01-16 Tokyo Gas Co Ltd 食品スチーマー
US5612380A (en) 1994-09-27 1997-03-18 The Scripps Research Institute Method for sleep induction
US5780472A (en) * 1995-01-11 1998-07-14 Samjin Pharmaceuticazl Co., Ltd. Piperazine derivatives and methods for the preparation thereof and compositions containing the same
ZA9610738B (en) * 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
CA2251700A1 (en) 1996-05-03 1997-11-13 Warner-Lambert Company Rapid purification by polymer supported quench
US5856537A (en) 1996-06-26 1999-01-05 The Scripps Research Institute Inhibitors of oleamide hydrolase
AU6179998A (en) * 1997-02-24 1998-09-09 Zymogenetics Inc. Calcitonin mimetics
JPH11139969A (ja) 1997-08-07 1999-05-25 Tanabe Seiyaku Co Ltd 医薬組成物
WO1999024421A1 (en) 1997-11-07 1999-05-20 Schering Corporation Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
WO1999026584A2 (en) 1997-11-24 1999-06-03 The Scripps Research Institute Inhibitors of gap junction communication
US6268367B1 (en) 1998-02-23 2001-07-31 Zymogenetics, Inc. Piperazine derivatives for treating bone deficit conditions
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
KR20060120715A (ko) 1998-03-31 2006-11-27 아카디아 파마슈티칼스 인코포레이티드 무스카린 수용체에 대해 활성을 갖는 화합물
GB9823873D0 (en) 1998-10-30 1998-12-30 Pharmacia & Upjohn Spa 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents
US6100279A (en) * 1998-11-05 2000-08-08 Schering Corporation Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
US6387900B1 (en) 1999-08-12 2002-05-14 Pharmacia & Upjohn S.P.A. 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
AU1413301A (en) * 1999-11-17 2001-05-30 Sumitomo Pharmaceuticals Company, Limited Diabetic remedy containing dipiperazine derivative
US6462054B1 (en) 2000-03-27 2002-10-08 The Scripps Research Institute Inhibitors of fatty acid amide hydrolase
MXPA03000458A (es) 2000-07-20 2004-06-02 Neurogen Corp Ligandos receptores de capsaicina.
DE10047760A1 (de) 2000-09-27 2002-04-11 Henkel Kgaa Zahnreinigungsmittel
US20020183316A1 (en) 2000-10-27 2002-12-05 Kevin Pan Amidoalkyl-piperidine and amidoalkyl-piperazine derivatives useful for the treatment of nervous system disorders
GB0031088D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
MXPA03009850A (es) 2001-04-27 2004-02-12 Bristol Myers Squibb Co Inhibidores de bisarilimidazolil de hidrolasa de amida del acido graso.
CN101624391A (zh) 2001-06-11 2010-01-13 病毒化学医药公司 用作黄病毒感染抗病毒剂的噻吩衍生物
WO2002100399A1 (en) * 2001-06-12 2002-12-19 Elan Pharmaceuticals, Inc. Macrocycles useful in the treatment of alzheimer's disease
WO2003037271A2 (en) * 2001-10-30 2003-05-08 Millennium Pharmaceuticals,Inc. Compounds, pharmaceutical compositions and methods of use therefor
AU2002351200A1 (en) 2001-12-03 2003-06-17 Gpc Biotech, Inc. Compositions and methods for inhibiting prenyltransferases
US6727247B2 (en) 2001-12-10 2004-04-27 Hoffman-La Roche Inc. Substituted benzothiazole amide derivatives
PL373970A1 (en) 2002-02-08 2005-09-19 Bristol-Myers Squibb Company (oxime)carbamoyl fatty acid amide hydrolase inhibitors
US20040110802A1 (en) 2002-08-23 2004-06-10 Atli Thorarensen Antibacterial benzoic acid derivatives
AU2003275493A1 (en) 2002-10-08 2004-05-04 The Scripps Research Institute Inhibitors of fatty acid amide hydrolase
FR2850377B1 (fr) 2003-01-23 2009-02-20 Sanofi Synthelabo Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique
DE10306250A1 (de) 2003-02-14 2004-09-09 Aventis Pharma Deutschland Gmbh Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7223788B2 (en) 2003-02-14 2007-05-29 Sanofi-Aventis Deutschland Gmbh Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
TW201018661A (en) * 2003-03-14 2010-05-16 Ono Pharmaceutical Co Heterocyclic rinf having nitrogen atom derivatives and medicament containing the derivatives as active ingredient
US20040191155A1 (en) 2003-03-25 2004-09-30 Mahler Barry Asher Thermal process for reducing the concentration of dinitrogen difluoride and dinitrogen tetrafluoride in nitrogen trifluoride
FR2854633B1 (fr) 2003-05-07 2005-06-24 Sanofi Synthelabo Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
ES2307025T3 (es) 2003-06-10 2008-11-16 Janssen Pharmaceutica Nv Combinacion de opioides y un derivado de la piperazina para el tratamiento del dolor.
US7262020B2 (en) 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
SE0401971D0 (sv) 2004-08-02 2004-08-02 Astrazeneca Ab Piperidne derivatives
US7725550B2 (en) 2004-12-17 2010-05-25 Nhn Corporation System and method for filtering message
SI1836179T1 (sl) * 2004-12-30 2015-07-31 Janssen Pharmaceutica N.V. Amidni derivati piperidin- in piperazin-1-karboksilne kisline in sorodne spojine kot modulatorji maščobnokislinske amidne hidrolaze (faah) za zdravljenje tesnobe, bolečine in drugih stanj
US7331398B2 (en) * 2005-06-14 2008-02-19 Schlumberger Technology Corporation Multi-drop flow control valve system
PE20070099A1 (es) 2005-06-30 2007-02-06 Janssen Pharmaceutica Nv N-heteroarilpiperazinil ureas como moduladores de la amida hidrolasa del acido graso
ITRM20060090A1 (it) 2006-02-22 2007-08-23 Sigma Tau Ind Farmaceuti Nuovi composti inibitori cpt a livello del snc come farmaci antidiabetici e o antiobesita
ES2350013T3 (es) 2006-05-18 2011-01-14 F. Hoffmann-La Roche Ag Derivados de tiazolo-pirimidina/piridina-urea como antagonistas de receptor de adenosina a2b.
WO2008024139A2 (en) 2006-08-18 2008-02-28 N.V. Organon Inhibitors of fatty acid amide hydrolase
CA2665804A1 (en) 2006-08-23 2008-02-28 Astellas Pharma Inc. Urea compound or salt thereof
ES2357340T3 (es) 2006-10-18 2011-04-25 Pfizer Products Inc. Compuestos de biaril éter urea.
RU2009148304A (ru) 2007-05-25 2011-06-27 Янссен Фармацевтика Н.В. (Be) Модуляторы гидролазы амидов жирных кислот на основе гетероарилзамещенной мочевины
EP2199282A4 (en) 2007-10-10 2011-04-27 Takeda Pharmaceutical AMIDE COMPOUND
WO2010068453A1 (en) 2008-11-25 2010-06-17 Janssen Pharmaceutica Nv Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
WO2010068452A1 (en) 2008-11-25 2010-06-17 Janssen Pharmaceutica Nv Heteroaryl-substituted urea modulators of fatty acid amide hydrolase

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