CR20180200A - Ciano tienotriazolpirazinas y usos de las mismas - Google Patents

Ciano tienotriazolpirazinas y usos de las mismas

Info

Publication number
CR20180200A
CR20180200A CR20180200A CR20180200A CR20180200A CR 20180200 A CR20180200 A CR 20180200A CR 20180200 A CR20180200 A CR 20180200A CR 20180200 A CR20180200 A CR 20180200A CR 20180200 A CR20180200 A CR 20180200A
Authority
CR
Costa Rica
Prior art keywords
diseases
bromodomain
compounds
proteins
bromodomains
Prior art date
Application number
CR20180200A
Other languages
English (en)
Inventor
Dennis; Buckley
Jun; Qi
Minoru; Tanaka
James E ; Bradner
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of CR20180200A publication Critical patent/CR20180200A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

La presente invención proporciona compuestos de fórmula (I) y (II) y sales farmacéuticamente aceptables de los mismos. Los compuestos de fórmula (I) y (II) son moléculas de unión a bromodominios y/o proteínas que contienen bromodominio (por ejemplo, proteínas bromo y extra terminal (BET)). También se proporcionan métodos, usos y kits que usan los compuestos y las composiciones farmacéuticas para inhibir la actividad (por ejemplo, la actividad aumentada) de los bromodominios y/o las proteínas que contienen bromodominio y para tratar y/o prevenir en un sujeto enfermedades asociadas con los bromodominios o las proteínas que contienen bromodominio (por ejemplo, enfermedades proliferativas, enfermedades cardiovasculares, infecciones víricas, enfermedades fibróticas, enfermedades metabólicas, enfermedades endocrinas y envenenamiento por radiación). Los compuestos, las composiciones farmacéuticas y los kits también son útiles para la contracepción masculina
CR20180200A 2015-09-11 2016-09-09 Ciano tienotriazolpirazinas y usos de las mismas CR20180200A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562217521P 2015-09-11 2015-09-11
PCT/US2016/051107 WO2017044849A1 (en) 2015-09-11 2016-09-09 Cyano thienotriazolodiazepines and uses thereof

Publications (1)

Publication Number Publication Date
CR20180200A true CR20180200A (es) 2018-05-31

Family

ID=58240288

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20180200A CR20180200A (es) 2015-09-11 2016-09-09 Ciano tienotriazolpirazinas y usos de las mismas

Country Status (20)

Country Link
US (1) US11306105B2 (es)
EP (1) EP3347021A4 (es)
JP (1) JP2018526421A (es)
KR (1) KR20180049058A (es)
CN (1) CN108472300A (es)
AU (1) AU2016319116B2 (es)
BR (1) BR112018004618A2 (es)
CA (1) CA2996974A1 (es)
CL (2) CL2018000621A1 (es)
CO (1) CO2018002483A2 (es)
CR (1) CR20180200A (es)
HK (1) HK1256417A1 (es)
IL (1) IL257594A (es)
MX (1) MX2018003031A (es)
PE (1) PE20181287A1 (es)
PH (1) PH12018550027A1 (es)
RU (1) RU2750164C2 (es)
SG (1) SG10202007090UA (es)
WO (1) WO2017044849A1 (es)
ZA (1) ZA201801548B (es)

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JP2017504653A (ja) 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド ジアミノピリミジンベンゼンスルホン誘導体およびその使用
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RU2750164C2 (ru) 2015-09-11 2021-06-22 Дана-Фарбер Кэнсер Инститьют, Инк. Цианотиенотриазолодиазепины и пути их применения
WO2017091673A2 (en) 2015-11-25 2017-06-01 Dana-Farber Cancer Institute, Inc. Bivalent bromodomain inhibtors and uses thereof
JP7417519B2 (ja) * 2017-09-22 2024-01-18 石薬集団中奇制薬技術（石家庄）有限公司 チエノジアゼピン誘導体とその応用
CN108084193A (zh) * 2017-12-19 2018-05-29 郭守东 一种brd4蛋白抑制剂
EP3849987B1 (en) * 2018-09-11 2024-04-17 F. Hoffmann-La Roche AG Tert-butyl (s)-2-(4-(phenyl)-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a] [1,4]diazepin-6-yl) acetate derivatives and related compounds as bromodomain brd4 inhibitors for treating cancer
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