CO2023014204A2 - Inhibidores de la cinasa relacionada con el gen nunca en mitosis a 7 (nek7) - Google Patents

Inhibidores de la cinasa relacionada con el gen nunca en mitosis a 7 (nek7)

Info

Publication number
CO2023014204A2
CO2023014204A2 CONC2023/0014204A CO2023014204A CO2023014204A2 CO 2023014204 A2 CO2023014204 A2 CO 2023014204A2 CO 2023014204 A CO2023014204 A CO 2023014204A CO 2023014204 A2 CO2023014204 A2 CO 2023014204A2
Authority
CO
Colombia
Prior art keywords
nek7
inhibitors
never
compounds
related kinase
Prior art date
Application number
CONC2023/0014204A
Other languages
English (en)
Inventor
John Sai Keong Kauwe Iii
Alexis Henri Abel Mollard
David James Bearss
Original Assignee
Halia Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Halia Therapeutics Inc filed Critical Halia Therapeutics Inc
Publication of CO2023014204A2 publication Critical patent/CO2023014204A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se proporcionan compuestos que tienen actividad como inhibidores de NEK7. Los compuestos tienen la Estructura (I): (I) o una sal, estereoisómero o profármaco farmacéuticamente aceptable del mismo, en donde A, X, Y, Z, R1, R 2, R3 y n son como se definen en la presente. También se proporcionan métodos asociados con la preparación y uso de estos compuestos, composiciones farmacéuticas que comprenden estos compuestos y métodos para modular la actividad del inflamasoma NLRP3.
CONC2023/0014204A 2021-04-05 2023-10-24 Inhibidores de la cinasa relacionada con el gen nunca en mitosis a 7 (nek7) CO2023014204A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163170708P 2021-04-05 2021-04-05
US202163185282P 2021-05-06 2021-05-06
PCT/US2022/023443 WO2022216680A1 (en) 2021-04-05 2022-04-05 Nek7 inhibitors

Publications (1)

Publication Number Publication Date
CO2023014204A2 true CO2023014204A2 (es) 2023-11-10

Family

ID=81448482

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0014204A CO2023014204A2 (es) 2021-04-05 2023-10-24 Inhibidores de la cinasa relacionada con el gen nunca en mitosis a 7 (nek7)

Country Status (9)

Country Link
EP (1) EP4320127A1 (es)
JP (1) JP2024513227A (es)
KR (1) KR20230175222A (es)
AU (1) AU2022255486A1 (es)
BR (1) BR112023019435A2 (es)
CA (1) CA3214042A1 (es)
CO (1) CO2023014204A2 (es)
IL (1) IL307258A (es)
WO (1) WO2022216680A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240158394A1 (en) * 2022-09-14 2024-05-16 Halia Therapeutics, Inc. Nek7 inhibitors

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
MXPA03008560A (es) 2001-03-22 2004-06-30 Abbot Gmbh & Co Kg Pirazolopirimidinas como agentes terapeuticos.
WO2006066174A1 (en) 2004-12-17 2006-06-22 Eli Lilly And Company Thiazolopyridinone derivates as mch receptor antagonists
WO2008046802A1 (en) 2006-10-16 2008-04-24 Novartis Ag Phenylacetamides useful as protein kinase inhibitors
EP2170871A2 (en) 2007-06-26 2010-04-07 GlaxoSmithKline LLC Processes for preparing benzimidazole thiophenes
UY33288A (es) 2010-03-25 2011-10-31 Glaxosmithkline Llc Derivados de indolina inhibidores de la proteina quinasa r del reticulo endoplasmatico
TWI535712B (zh) 2010-08-06 2016-06-01 阿斯特捷利康公司 化合物
CA2867760C (en) 2012-04-04 2021-10-05 Rigel Pharmaceuticals, Inc. Indolizinyl derivatives as protein kinase c inhibitors and uses thereof
WO2013170770A1 (zh) 2012-05-16 2013-11-21 上海医药集团股份有限公司 具有抗肿瘤活性的乙炔衍生物
JP6186434B2 (ja) 2012-07-18 2017-08-23 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． 窒素複素環誘導体及びその医薬品への応用
US8859553B2 (en) 2012-07-30 2014-10-14 Astar Biotech Llc Protein kinase inhibitors
US9604980B2 (en) 2012-11-07 2017-03-28 Nerviano Medical Sciences S.R.L. Substituted pyrimidinyl and pyridinyl-pyrrolopyridinones, process for their preparation and their use as kinase inhibitors
CN105431436B (zh) 2013-05-14 2017-11-28 内尔维阿诺医学科学有限公司 吡咯并[2,3‑d]嘧啶衍生物，它们的制备方法和它们作为激酶抑制剂的用途
JP6380861B2 (ja) 2013-06-28 2018-08-29 ベイジーン リミテッド Ｒａｆキナ−ゼおよび／またはＲａｆキナ−ゼの二量体阻害剤としての縮合三環式ウレア系化合物
BR112016017997A2 (pt) 2014-02-03 2017-08-08 Quadriga Biosciences Inc Beta aminoácidos beta-substituídos e análogos como agentes quimioterapêuticos
EP3186247B1 (en) 2014-08-26 2021-03-03 Astar Biotech LLC Protein kinase inhibitors
CN105837575B (zh) 2015-01-13 2019-01-15 四川大学 3-乙炔基吡唑并嘧啶衍生物及其制备方法和用途
WO2017117393A1 (en) 2015-12-30 2017-07-06 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
CN107513068A (zh) 2016-06-16 2017-12-26 中国科学院上海药物研究所 一种具有fgfr抑制活性的新型化合物及其制备和应用
US10870647B2 (en) 2016-06-20 2020-12-22 Daegu-Gyeongbuk Medical Innovation Foundation Imidazopyridine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for preventing or treating cancer
KR102500416B1 (ko) 2016-06-21 2023-02-17 네르비아노 메디칼 사이언시스 에스.알.엘. 키나제 억제제로서의 n-(치환된-페닐)-설폰아미드 유도체
EP3296297A1 (en) 2016-09-15 2018-03-21 Centre National De La Recherche Scientifique Benzimidazol derivatives for treating filovirus infection
WO2018102751A1 (en) 2016-12-02 2018-06-07 Quentis Therapeutics, Inc. Ire1 small molecule inhibitors
EP3630778A1 (en) 2017-05-26 2020-04-08 Ichnos Sciences SA Novel inhibitors of map4k1
WO2018222917A1 (en) 2017-06-01 2018-12-06 Quentis Therapeutics, Inc. Ire1 small molecule inhibitors
US11318212B2 (en) 2017-08-31 2022-05-03 Daiichi Sankyo Company, Limited Method for producing antibody-drug conjugate
WO2019192962A1 (en) * 2018-04-05 2019-10-10 Merck Patent Gmbh Heteroaryl compounds as type ii irak inhibitors and uses hereof
KR102548191B1 (ko) 2018-04-09 2023-06-28 상하이테크 유니버시티 표적 단백질 분해 화합물, 이의 항종양 응용, 이의 중간체 및 중간체의 응용
US20210139484A1 (en) 2018-04-11 2021-05-13 Gossamer Bio Services, Inc. Dihydroisoquinoline-2(1h)-carboxamide and related compounds and their use in treating medical conditions
TW202016109A (zh) 2018-06-13 2020-05-01 英屬開曼群島商百濟神州有限公司 作為hpk1抑制劑的吡咯並[2,3-b]吡啶或吡咯並[2,3-b]吡嗪及其用途
WO2020135507A1 (zh) 2018-12-26 2020-07-02 杭州百新生物医药科技有限公司 一种多取代苯氨基嘧啶衍生物及其制备方法和用途
CN111646995B (zh) * 2019-03-04 2023-03-21 四川大学 4-氨基-嘧啶并氮杂环-苯基脲类衍生物及其制备方法和用途
WO2020206583A1 (en) 2019-04-08 2020-10-15 Qilu Regor Therapeutics Inc. Kinase inhibitors and uses thereof
AU2020355359B2 (en) * 2019-09-26 2023-08-24 Shenzhen Targetrx, Inc. Substituted aromatic fused ring derivative and composition comprising same, and use thereof
KR20220099958A (ko) 2019-10-01 2022-07-14 골드핀치 바이오 인코포레이티드 Cdk5의 치환된 1,6-나프티리딘 억제제
CN115210226B (zh) 2020-02-20 2024-01-09 广州白云山医药集团股份有限公司白云山制药总厂 喹啉类化合物
WO2021226547A2 (en) 2020-05-08 2021-11-11 Halia Therapeutics, Inc. Targeted nek7 inhibition for modulation of the nlrp3 inflammasome
CN113717156B (zh) 2020-05-25 2023-05-09 南京红云生物科技有限公司 Egfr抑制剂、其制备方法及用途
GB202010464D0 (en) 2020-07-08 2020-08-19 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of diseases

Also Published As

Publication number Publication date
JP2024513227A (ja) 2024-03-22
IL307258A (en) 2023-11-01
CA3214042A1 (en) 2022-10-13
KR20230175222A (ko) 2023-12-29
EP4320127A1 (en) 2024-02-14
BR112023019435A2 (pt) 2023-10-24
AU2022255486A1 (en) 2023-10-19
WO2022216680A1 (en) 2022-10-13

Similar Documents

Publication Publication Date Title
DOP2022000124A (es) Derivados de pirazolilo útiles como agentes anticancerígenos
CO2019011762A2 (es) Compuestos que inhiben la proteína mcl-1
CO2022017622A2 (es) Inhibidores de quinasa nek7
CO2022019131A2 (es) Inhibidores de la quinasa nek7
UY29087A1 (es) Derivados de adamantilo, composiciones farmaceuticas que los contienen, procesos para su preparacion y uso terapeutico
UY28979A1 (es) Derivados de hidrocloruros de 3-carboxamida, composiciones farmacéuticas que los contienen, procedimiento de preparación y su uso, útiles como inhibidores selectivos de gsk3
GT200500325A (es) Pirazolo-pirimidinas 1,4-sustituidas como inhibidores de quinasa
CO2023014204A2 (es) Inhibidores de la cinasa relacionada con el gen nunca en mitosis a 7 (nek7)
CL2022002695A1 (es) Inhibidores de rip1k
CL2020003380A1 (es) Compuestos que aumentan la actividad del proteosoma.
MX2020003993A (es) Derivados de bencimidazol y sus usos.
CO2022009510A2 (es) Compuestos activos frente a receptores nucleares
DOP2019000100A (es) Derivados de naftiridinona y su uso en el tratamiento de la arritmia
CL2021002107A1 (es) Triamtereno o nolatrexed para uso en el tratamiento de fenilcetonuria.
UY38998A (es) Derivados de bencimidazol, su uso en medicina y composiciones que los contienen
AR127681A1 (es) Inhibidores lisina acetiltransferasa 6a (kat6a) y usos de los mismos
CO2023012903A2 (es) Derivados de pirimidina útiles como inhibidores de la proteína cinasa de repetición 2 rica en leucina (lrrk2)
CO2022008616A2 (es) Composición farmacéutica oral que comprende compuesto de carbamato y método de preparación para la misma
PE20210550A1 (es) Compuestos de 4-metildihidropirimidinona y su uso farmaceutico
PE20191819A1 (es) Analogos de deutetrabenazina, su preparacion y uso
UY37412A (es) Compuestos de indazol para uso en lesiones de tendones y/o ligamentos
ECSP23070418A (es) Moduladores de sting (estimulador de genes de interferón)
UY39625A (es) Derivados tricíclicos útiles como inhibidores de parp7
AR119317A1 (es) Un derivado de tetrahidroisoquinolina sustituido como modulador alostérico positivo de d1
UY38133A (es) Nuevos inhibidores de cdk8/19