CN1791391A - 含有高级脂肪酸衍生物的组合物以及饮食物 - Google Patents
含有高级脂肪酸衍生物的组合物以及饮食物 Download PDFInfo
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- CN1791391A CN1791391A CNA038265486A CN03826548A CN1791391A CN 1791391 A CN1791391 A CN 1791391A CN A038265486 A CNA038265486 A CN A038265486A CN 03826548 A CN03826548 A CN 03826548A CN 1791391 A CN1791391 A CN 1791391A
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- Prior art keywords
- fatty acid
- higher fatty
- acid derivative
- mentioned
- sodium
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Abstract
本发明的目的在于提供一种可以以低成本容易地制备、并且作为由食物、饮食限制等各种原因诱发的骨质疏松症预防治疗药是有效的、安全性高且可以常用的含有高级脂肪酸衍生物的组合物,以及含有该组合物、作为由食物、饮食限制等各种原因诱发的骨质疏松症预防治疗剂是有效的、并且作为医院用饮食品、保健饮料或食品、饲料等合适的饮食物。上述含有高级脂肪酸衍生物的组合物的特征是含有至少1种高级脂肪酸衍生物作为有效成分,并可以作为骨质疏松症预防治疗药使用。上述高级脂肪酸衍生物优选含有二十八烷醛。上述饮食物的特征是含有上述含有高级脂肪酸衍生物的组合物。
Description
技术领域
本发明涉及一种可以以低成本容易地制造、并且作为安全性高且可以常用的骨质疏松症预防治疗药的含有高级脂肪酸衍生物的组合物,以及含有该组合物、并且作为医院用饮食品、健康饮料或食品、安全饲料等可以常用的饮食物。
背景技术
近年,由于食物、饮食内容的变化、长寿化等各种主要原因引起的骨质疏松症患者增加,已经成为问题。该骨质疏松症由于更年期后的激素分泌的降低或激素分泌异常性疾病等而发病,是骨密度降低,从而骨变得容易折断的疾病。特别是,大腿骨骨折的老龄患者恢复慢,继脑中风、衰老而成为嗜睡患者的第3位的原因而被举出,已经成为了社会性的一大问题。
在骨质疏松症患者中,最成为问题的是易骨折性和疼痛,被医生诊断为骨质疏松症的患者,进行了给与***的激素补充疗法、二磷酸盐、ラロキシフェン、降钙素、钙剂、维生素D、维生素K、异丙氧黄酮等的给药。
可是,骨密度降低程度轻的潜在的患者,由于不表现特别的症状,不具有接受医生诊断的动机,漏诊的情况很多。有报道说,在日本有约500万潜在的患者,特别是女性,50岁年龄段约为20%、60岁年龄段约为48%、70岁年龄段约为70%、80岁年龄段约为85%的人的骨密度降低。
存在大量潜在的骨质疏松症患者的现状中,可以说,比医生的处方的医药品还有效的是温和疗法,另一方面,优选通过日常的饮食和健康食品、辅助食品(サプリメント)等简便地摄取对骨质疏松症的预防治疗有效的物质。鉴于这样的现状,提出了各种骨质疏松症预防治疗药和保健食品。例如,提出了含有二十八烷醇的巴西原产的白薯具有女性荷尔蒙作用(参照专利文献1)。另外,还提出了将碳原子数为22~38的直链饱和醇的1种或2种以上作为有效成分的骨质疏松症预防治疗药(参照专利文献2)。
另一方面,着眼于上述的二十八烷醇另外的作用,还提出了具有刺激体力的增进和性激素的作用(参照专利文献3)、使胆固醇值降低的作用(参照专利文献4)。另外,着眼于上述二十八烷醇和类似的二十八烷醛发挥的作用,提出了具有增进体力效果和恢复疲劳效果的营养食品(参照专利文献5)。另外,提出了碳原子数27的直链脂肪醛等具有使胆固醇值降低的作用(参照专利文献6)。
虽然提出了各种骨质疏松症治疗药等,但仍然期望提供更加新型的、可以以低成本容易地制备,并且作为由食物、饮食限制等各种主要原因诱发的骨质疏松症预防治疗药有效的、可以适用于各种用途、安全性高且可以常用的组合物或饮食物。
专利文献1:特开昭63-283552号公报
专利文献2:特开平4-266820号公报
专利文献3:特开平4-278061号公报
专利文献4:特表平7-505414号公报
专利文献5:特开平1-225461号公报
专利文献6:特开昭59-53427号公报
本发明根据上述要求,以实现以下的目的作为课题。即,本发明的目的在于提供一种可以以低成本容易地制造,并且作为由食物、饮食限制等各种原因诱发的骨质疏松症预防治疗药是有效的、安全性高且可以常用的含有高级脂肪酸衍生物的组合物,以及含有该组合物、作为由食物、饮食限制等各种原因诱发的骨质疏松症预防治疗药是有效的、并且作为医院用饮食品、健康饮料或食品、饲料等的合适的饮食物。
发明内容
本发明的含有高级脂肪酸衍生物的组合物的特征是:含有至少1种高级脂肪酸衍生物作为有效成分,并且用作预防治疗骨质疏松症的药物。
该含有高级脂肪酸衍生物的组合物由于含有至少1种高级脂肪酸衍生物作为有效成分,故可以适于作为预防治疗骨粗松症的药物使用。
本发明的饮食物的特征是:含有本发明的上述含有高级脂肪酸衍生物的组合物。
该饮食物将天然成分作为有效成分,安全并且特别适合作为医院用、日常用、饲养用等的饮食品。
具体实施方案
(含有高级脂肪酸衍生物的组合物)
本发明的含有高级脂肪酸衍生物的组合物含有至少1种高级脂肪酸衍生物作为有效成分,另外,根据目的还可以含有适当选择的其他的成分。
—高级脂肪酸衍生物—
作为上述高级脂肪酸衍生物,只要是高级脂肪酸的衍生物就没有特别的限制,可以根据目的进行适当选择,例如,可以举出含有羟基的高级脂肪酸、含有醛基的高级脂肪酸等。
作为上述含有羟基的高级脂肪酸,只要具有羟基,则没有特别限制,例如,可以举出二十四烷醇、二十六烷醇、二十七烷醇、二十八烷醇、二十九烷醇等。这些当中,优选二十八烷醇。
作为上述含有醛的高级脂肪酸,只要具有醛基,则没有特别限制,例如,可以举出二十四烷醛、二十六烷醛、二十七烷醛、二十八烷醛、二十九烷醛等。这些当中,特别优选二十八烷醛(ォクタコサナ一ル)。
这些既可以1种单独使用,也可以2种或2种以上同时使用。这些当中,特别优选含有醛基的高级脂肪酸。另外,在同时使用2种或2种以上上述高级脂肪酸衍生物时,优选上述二十八烷醇和上述二十八烷醛的并用(混合物)。
上述高级脂肪酸衍生物既可以是化学合成品,也可以是来自天然的物质。为后者时,在饮食物用途中,在安全性这点上是有利的,其中,优选天然物的提取物。
作为上述高级脂肪酸衍生物中的碳原子数,没有特别的限制,可以根据目的进行适当选择,但优选例如24~38,更加优选26~32。
作为上述高级脂肪酸衍生物的制备方法,没有特别的限制,可以根据目的进行适当的选择,例如,可以举出从天然物提取的方法、公知的合成方法等。这些当中,从可以更加简便地以低成本制备这点看,优选从天然物中提取的方法。
作为上述天然物,没有特别的限制,例如,可以举出砂糖黍(甘蔗)、粗米胚芽、麦芽、苹果皮、椰子果实等。
以下,对作为上述高级脂肪酸衍生物的上述二十八烷醛的制备方法的一例进行说明。即,首先使用甘蔗作为上述天然物,将该甘蔗的茎皮切细成细片后,加入苯、异丙醇、己烷等有机溶剂,在30~80℃的温度条件下加热10分钟~数小时左右,进行过滤。将通过减压浓缩该滤液而得到的油脂状物质进行硅胶柱层析,再用薄层色谱法将溶出到苯等有机溶剂中的初期级分进行精制,收集Rf值约为0.60~0.65的级分,通过重结晶可以制备上述二十八烷醛。
另外,由于上述油脂状物质通常含有60~90质量%的上述二十八烷醛,因此,也可以通过使该油脂状物质中含有其他的成分,直接制成制剂。
作为上述含有高级脂肪酸衍生物的组合物中的上述高级脂肪酸衍生物的含量,没有特别的限制,可以根据目的进行适当选择。
—其他成分—
作为上述其它成分,只要不妨碍本发明的目的,则没有特别限制,可以根据目的适当选择,例如,可以举出药效成分、添加剂等。
作为上述药效成分,可以举出,例如,生药、维生素类、止泻药、整肠药、抗溃疡药、健胃消化药、抗酸剂、消化酶药、止咳药、利胆剂、抗组胺药、镇定药、抗癫痫药、解热镇痛消炎药、镇痉药、利尿剂、强心剂、降血压药、血管扩张药、抗心律失常药、溶栓药、高血脂症用药、支气管扩张药、止喘药、抗过敏药、抗生素、抗病毒药、激素药等。
作为上述生药,可以举出,例如,阿仙药、甘茶、茴香、郁金、延命草、黄芩、黄连、艾叶、葛根、甘草、桂皮、牻牛儿苗、厚朴、藏红花、山楂、芍药、生姜、番泻树、当药、丁香、陈皮、桐皮、白术、防风、麻黄、龙骨、连翘等。这些可以作为浓缩剂添加,另外,也可以作为提取物、粉末添加。
作为上述维生素药,可以举出,例如,视黄醇、视黄醛等维生素A组;胡萝卜素类、维生素B1、维生素B2、维生素BW等维生素B组;抗坏血酸等维生素C组;维生素D3、维生素D2等维生素D组;α-生育酚、生育三烯酸等维生素E组;维生素K1、维生素K2等维生素K组;烟酸、泛酸、叶酸等、以及它们的衍生物或它们的盐等。
作为上述添加剂,没有特别限制,可以举出,例如,稳定剂、表面活性剂、增溶剂、缓冲剂、甜味剂、矫味剂、悬浮剂、抗氧剂、清凉剂、着香剂·香料、乳化剂、pH调节剂、分散剂、芳香剂、防腐剂、保存剂等。
作为上述稳定剂,可以举出,例如,己二酸、抗坏血酸、L-抗坏血酸钠、L-天冬氨酸、L-天冬氨酸钠、亚硫酸钠、L-精氨酸、苯甲酸钠、肌醇、依地酸钠、异抗坏血酸、异抗坏血酸钠、柠檬酸钠、甘氨酸、甘油、甘油脂肪酸酯、轻质二氧化硅、生育酚乙酸酯、明胶、大豆油非皂化物、聚氧乙烯聚丙二醇、无水柠檬酸钠、单硬脂酸甘油脂、磷酸氢钠等。
作为上述表面活性剂,可以举出,例如,胆固醇、蔗糖脂肪酸酯、硬脂醇、山梨糖醇酐倍半油酸酯、十六烷醇、山梨糖醇酐脂肪酸酯、聚环氧乙烷蓖麻油、聚环氧乙烷聚氧化丙二醇、聚山梨酸酯、聚乙二醇、脱水山梨糖醇单油酸酯、甘油单硬脂酸酯、脱水山梨糖醇单月桂酸酯、十二烷基硫酸钠、聚桂醇(ラゥロマクロゴ一ル)等。
作为上述增溶剂,可以举出,例如,L-天冬氨酸、L-精氨酸、苯甲酸钠、乙醇、氯化钠脱水山梨糖醇脂肪酸酯、碳酸氢钠、聚环氧乙烷固化蓖麻油、聚环氧乙烷聚氧化丙二醇、聚山梨酸酯、聚乙烯醇、D-甘露糖醇、无水乙醇等。
作为缓冲剂,可以举出,例如,抗坏血酸、L-天冬氨酸镁、氨乙基磺酸、L-精氨酸、苯甲酸、苯甲酸钠、柠檬酸、柠檬酸钙、柠檬酸钠、柠檬酸二钠、甘氨酸、碳酸氢钠、乳酸、葡萄糖、柠檬酸酐、无水柠檬酸钠、无水磷酸一氢钠、偏磷酸钠、磷酸氢钠、磷酸氢二钾、磷酸二氢钾、磷酸二氢钠等。
作为上述甜味剂,可以举出,例如,阿斯巴甜、甘茶、甘草、果糖、果糖葡萄糖液、葡萄糖果糖液体糖、还原麦芽糖糖稀、甘草酸二钾、甘草酸单铵、ァセスルファムカリゥム、高果糖液体糖、葡萄糖、糖稀、乳糖、白糖、精制白糖、蜂蜜、糖精、糖精钠、斯特维亚菊、スクラロ一ス、赤藓醇、木糖醇、D-山梨糖醇、マルチト一ル、麦芽糖、D-甘露糖醇、单糖浆等。
作为上述矫味剂,可以举出,例如,抗坏血酸、L-天冬氨酸、DL-丙氨酸、5’-肌苷酸钠、茴香、氯化钠、橙皮油、可可粉末、樟脑、甘氨酸、甘油、L-谷氨酸、藏红花、酒石酸、生姜、D-山梨糖醇、薄荷、己二酸、富马酸、薄荷(ペパ一ミント)、冰片、薄荷醇、龙脑、绿茶末、苹果汁、苹果醋、柠檬油、玫瑰油、蜂王浆等。
作为上述悬浮剂,可以举出,例如,***胶、角叉菜胶(カラギ一ナン)、羧基乙烯基聚合物、琼脂、黄原胶、甘油脂肪酸酯、氧化钛、蔗糖脂肪酸酯、硬脂醇、硬脂酸铝、十六烷醇、精制明胶、脱水山梨糖醇脂肪酸酯、大豆卵磷脂、丙二醇脂肪酸酯、果胶、丙二醇、聚环氧乙烷固化蓖麻油、聚乙二醇、甲基纤维素、甘油单硬脂酸酯、液体石蜡等。
作为上述抗氧剂,可以举出,例如,抗坏血酸、L-抗坏血酸硬脂酸酯、亚硫酸氢钠、亚硫酸钠、异抗坏血酸、盐酸半胱氨酸、生育酚乙酸酯、大豆卵磷脂、丁基羟基苯甲醚、没食子酸丙酯等。
作为上述清凉剂,可以举出,例如,香叶醇、薄荷水、薄荷油、冰片、薄荷醇、薄荷等。
作为上述着香剂·香料,可以举出,例如,茴香、乙基香草醛、乙基麦芽醇、橙子、樟脑、桂皮、糖香味调料、肉桂醛、樱桃香味调料、トゥヒチンキ、薄荷、香草香味调料、香草醛、苦味香料、水果香味调料、香味调料GI、苦艾酒香味调料、混合香味调料、薄荷香味调料、薄荷醇、桉树油、龙脑、柠檬粉、柠檬油、松香、玫瑰油等。
作为上述乳化剂,可以举出,例如,角叉菜胶、羧基乙烯基聚合物、羧甲基纤维素钠、瓜尔胶、甘油脂肪酸酯、二硬脂酸聚乙二醇、蔗糖脂肪酸酯、硬脂醇、硬脂酸、十六烷醇、明胶、脱水山梨糖醇脂肪酸酯、大豆卵磷脂、羟丙基纤维素、丙二醇、丙二醇脂肪酸酯、聚环氧乙烷聚氧化丙二醇、聚山梨酸酯、肉豆蔻醇、甘油单硬脂酸酯、脱水山梨糖醇单月桂酸酯、十二烷基硫酸钠等。
作为上述pH调节剂,可以举出,例如,稀盐酸、柠檬酸钠、甘氨酸、琥珀酸、醋酸、酒石酸、氢氧化钠、碳酸氢钠、碳酸钠、富马酸一钠、磷酸、磷酸三钠、磷酸氢钠、磷酸氢二钾、磷酸二氢钠等。
作为上述分散剂,可以举出,例如,氨基烷基甲基丙烯酸酯聚合物RS、***胶、油酸、羧基乙烯基聚合物、羧甲基纤维素钠、甘油、结晶纤维素、磷酸胆碱盐、卵磷脂、脱水山梨糖醇倍半油酸酯、糊精、玉米淀粉、脱水山梨糖醇三油酸酯、羟乙基纤维素、羟丙基纤维素、甲基纤维素、甘油单硬脂酸酯、十二烷基硫酸钠、液体石蜡等。
作为上述芳香剂,可以举出,例如,茴香、乙基香草醛、橙皮油、樟脑、桂皮、生姜、沉香、丁香、薄荷、香草、香草醛、冰片、麦芽醇、薄荷醇、薄荷醇、桉树、龙脑、柠檬、玫瑰水等。
作为上述防腐剂,可以举出,例如,氨基乙磺酸、苯甲酸、苯甲酸钠、乙醇、依地酸钠、琼脂、柠檬酸钠、水杨酸钠、山梨酸、对羟基苯甲酸异丙酯、对羟基苯甲酸乙酯、薄荷醇等。
作为上述保存剂,可以举出,例如,苯甲酸钠、依地酸钠、甘油、水杨酸、水杨酸钠、D-山梨糖醇、山梨酸、对羟基苯甲酸异丁酯、对羟基苯甲酸乙酯、对羟基苯甲酸丁酯、对羟基苯甲酸甲酯、丙二醇等。
作为上述骨质疏松症预防治疗药的剂型,没有特别限制,可以根据目的适当选择,例如,可以作为粉末、细粒、颗粒、微胶囊等固体药,另外,还可以将这些作成片剂、薄膜包衣剂、咀嚼片、カプレット,也可以填充到胶囊等中。另外,也可以通过适当选择的溶剂进行溶剂化或悬浮化,作成液体药物。
本发明含有高级脂肪酸衍生物的组合物,可以在日常简便地摄取,并且安全性高,可以有效地发挥骨质疏松症的预防和治疗中的至少一种效果,可以特别优选使用以下说明的本发明的饮食物。
(饮食物)
作为本发明的饮食物,含有上述含有高级脂肪酸衍生物的组合物,并且还可以根据需要含有适当选择的其他成分等。
作为本发明饮食物的用途,没有特别限制,可以根据目的适当选择,例如,可以适用于食品、饮料、饲料等各种用途。
作为上述食品,可以举出,例如,常用食品、医院食品、营养辅助食品或疾病预防治疗食品等保健功能食品等。作为这些的具体例子,可以举出,冰淇淋、果子露冰淇淋、刨冰等冰果;荞麦面、面条、粉丝、饺子皮、烧麦皮、中华面、速食面等面类;饴糖、冰糖、口香糖、巧克力、片果、小点心、饼干、果冻、果酱、奶油、烤制点心、面包等点心类;蟹、鲑、蛤仔、金枪鱼、沙丁鱼、虾、松鱼、鲐鱼、鲸鱼、牡蛎、秋刀鱼、墨鱼、魁蛤、扇贝、鲍鱼、海胆、盐渍鲑鱼子、小蛤蜊等水产品;鱼糕、火腿、香肠等水产·畜产加工食品;加工乳、发酵乳等乳制品;色拉油、炸油、人造奶油、沙拉酱、猪油代用品、加糖后起泡的奶油、调味汁等油脂以及油脂加工食品;调味汁、调料汁等调味料;咖喱、炖饭(シチュ一)、鸡肉鸡蛋大腕盖饭、粥、杂吹、中华饭、油炸鸡块大碗盖饭、炸虾大碗盖饭、大碗鳝鱼盖饭、豆芽饭、杂烩、麻婆豆腐、大碗牛肉盖饭、肉食调味汁、鸡蛋汤、蛋包饭、饺子、烧麦、汉堡、肉丸子等软罐头食品等。
作为上述饮料,可以举出优选例如,常用饮料、医院饮料、营养辅助饮料或疾病预防治疗饮料等保健功能饮料等。作为这些的具体例子,可以举出,例如,清凉饮料、碳酸饮料、营养饮料、果实饮料、乳酸饮料等。
作为上述饲料,可以举出优选例如,猪用饲料、牛用饲料、鸡用饲料、马用饲料、宠物食品等。另外,作为上述宠物食品,可以举出,例如,狗用宠物食品、猫用宠物食品等。
作为上述饮食物中的含有上述高级脂肪酸衍生物的组合物的含量,没有特别限制,可以根据目的适当选择。
本发明的饮食物,可以在日常简便地摄取,并且安全性高,并且对骨质疏松症的预防和治疗的至少一种是有效的。
以下,对本发明的实施例进行说明,但本发明不受这些的任何限制。
(实施例1)
—骨质疏松症预防治疗药的制备—
用削皮器削取作为上述天然物的甘蔗的茎的表皮,在其30g中加入600ml苯,边搅拌边在60℃的温度条件下加热30分钟。过滤加热后的上述苯溶液,并将其滤液在氮气气流下于40℃进行减压浓缩直至干固,得到白色的油脂状物质7.2g。接着,在填充了预先用苯洗净的硅胶(100目或100目以上)的柱中,投入将上述油脂状物质溶解在苯中的溶液,用苯进行洗脱。对各种级分,使用正己烷和苯的混合物[正己烷∶苯=1∶1(v/v)]作为展开溶剂进行硅胶薄层色谱分离,收集Rf值为0.62的级分。将该级分在氮气气流下进行浓缩干固,得到2.1g蜡状结晶(骨质疏松症预防治疗药A)。
(实施例2)
—骨质疏松症预防治疗药的制备—
在1.0g二十八烷醇(东京化成社制造)中加入300ml的CH2Cl2、5.0g的CaCO3以及2.0g分子筛(三光纯药社制造,MS4A),在室温下进行30分钟的搅拌。在其中加入3.0g氯化铬酸吡啶鎓盐,在室温下进行2小时的反应。再加入5.0g的CaCO3和10.0g硅藻土以及300ml己烷,搅拌15分钟后,进行过滤,得到粗精制物。使用硅胶柱(2.0×60cm)、用质量混合比为正己烷∶苯=3∶1的洗脱溶剂将该粗精制物进行精制,得到456.8mg二十八烷醛(骨质疏松症治疗药B)(收率45.9%)。
另外,对得到的二十八烷醛进行1H-NMR(300MHz)以及质谱分析(EI法),结果如下所示。
<1H-NMR化学位移δ(所属氢原子)>
0.88(3H,t,J6.7Hz),1.63(2H,m),2.42(2H,dt,J2.0和7.0Hz),9.77(1H,t,J1.8Hz)
<质谱分析结果>
作为C28H56O,分子量计算值:408.4331
质谱的分子量峰:408.4326
(实施例3以及比较例1~2)
—饲料的制备—
按照通常的方法,制备含有下述表1的组成的标准饲料、限制饲料(1)。另外,在该限制饲料(1)中添加上述制备的二十八烷醇(上述骨质疏松症预防治疗药B)来制备限制饲料(2)使每只大鼠每天的摄取量为7mg,对各种饲料进行以下的评价。结果示于表2。
表1
比较例1 | 比较例2 | 实施例3 | |
标准饲料(g/100g) | 限制饲料(1)(g/100g) | 限制饲料(2)(g/100g) | |
酪蛋白 | 20.0 | 40.0 | 40.0 |
β-玉米淀粉 | 39.7 | 29.7 | 29.7 |
α-玉米淀粉 | 13.2 | 8.2 | 8.2 |
蔗糖 | 10.0 | 0.0 | 0.0 |
大豆油 | 7.0 | 7.0 | 7.0 |
纤维素 | 5.0 | 5.0 | 5.0 |
矿物质混合物 | 3.5 | 7.0 | 7.0 |
维生素混合物 | 1.0 | 2.0 | 2.0 |
L-胱氨酸 | 0.3 | 0.6 | 0.6 |
酒石酸氢化胆碱 | 0.25 | 0.5 | 0.5 |
叔丁基氢醌 | 0.0014 | 0.0028 | 0.0028 |
二十八烷醛 | - | - | 7mg/头/天 |
<断裂能量评价>
将上述制备的标准饲料、限制饲料(1)以及(2)给予大鼠骨质疏松症模型(Sun et al.,J.Jap.Soc.Nutrition and Food Science,55(3),149-155,2002),按照以下的方法进行。
准备15例雌性大鼠(日本ェスェルシ一社制造,Wister系,实验开始时为六周龄,体重为100~110g),每笼各放入1例,在温度25±2℃、相对湿度60±5%、每隔12小时的明暗条件下进行1周的预备饲养。此期间,使其自由摄取上述标准饲料以及自来水,算出每1例的平均摄食量(g/头/天)。
将15例大鼠分为3组(对照组、限制饲料组、试验组),每组各5例,并使每组的平均体重大致相等。使上述对照组自由摄取上述标准饲料(1),对上述限制饲料组,1天1次,在每天上午11:00摄取作为平均摄食量的一半的量的上述限制饲料(2),对上述试验组,与上述限制饲料同样地摄取上述限制饲料(2)。上述自来水各组均可自由摄取。
在上述条件下,饲养4周后,将各个大鼠用戊巴比妥钠进行麻醉,从腹部大动脉进行全采血后屠杀。然后进行解剖检查,用肉眼检查后,摘出两侧的大腿骨。使用该摘出的右侧的大腿骨,按照Peng等的方法(J.Bone Miner.Res.,2,249-257,1987),进行断裂能量的测定。
<骨密度评价>
对上述摘出的左侧的大腿骨,用二重能量X射线吸收测定法(Aloka company公司制造,骨密度测定装置DCS-600型),以间隔1.0mm进行测定,并进行图像处理来计算出骨密度。
<血清***浓度>
将上述采取的血液进行离心分离取出血清,按照通常的方法,使用***EIA试剂盒(フナコシ社制造)进行***浓度的测定。
表2
比较例1 | 比较例2 | 实施例3 | |
标准饲料 | 限制饲料(1) | 限制饲料(2) | |
断裂能量(10-3J) | 27.64 | 18.06 | 26.34 |
大腿骨骨密度(g/cm2) | 0.107±0.02 | 0.060±0.01 | 0.083±0.017 |
血清***浓度(μg/ml) | 2.48 | 1.68 | 1.48 |
如表2所示,摄取限制饲料(1)的组,与摄取标准饲料的组相比断裂能量低,骨容易折断。可是,摄取限制饲料(2)的组与摄取了标准饲料的组具有几乎相同的断裂能量。另外,还可以知道对于大腿骨骨密度,也与上述断裂能量的测定结果同样,摄取了标准饲料的组和摄取了限制饲料(2)的组具有大致相同的骨密度。
另外,对于上述***浓度,摄取了限制饲料(1)的组和摄取了限制饲料(2)的组也发现确认到差别。
工业实用性
按照本发明,可以提供一种可以以低成本容易地制备,并且作为由食物、饮食限制等各种主要原因诱发的骨质疏松症预防治疗药是有效的、安全性高且可以常用的含有高级脂肪酸衍生物的组合物,以及含有该组合物、作为由食物、饮食限制等各种主要原因诱发的骨质疏松症预防治疗药是有效的、并且合适作为医院用饮食品、健康饮料或食品、饲料等的饮食物。
Claims (5)
1.一种含有高级脂肪酸衍生物的组合物,其特征在于,含有至少1种的高级脂肪酸衍生物作为有效成分,并且作为预防治疗骨质疏松症的药物使用。
2.按照权利要求1中记载的含有高级脂肪酸衍生物的组合物,其中,含有碳原子数为24~38的高级脂肪酸衍生物。
3.按照权利要求1~2中任一项记载的含有高级脂肪酸衍生物的组合物,其中,高级脂肪酸衍生物含有二十八烷醛。
4.按照权利要求3中记载的含有高级脂肪酸衍生物的组合物,其中,高级脂肪酸衍生物含有二十八烷醇。
5.一种饮食物,其特征在于,含有权利要求1~4中的任一项记载的含有高级脂肪酸衍生物的组合物。
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Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
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US20060286223A1 (en) * | 2005-06-15 | 2006-12-21 | Carol Long | Reduced sugar RTE cereals with maltodextrin |
US8435587B2 (en) * | 2005-11-23 | 2013-05-07 | The Coca-Cola Company | High-potency sweetener composition with long-chain primary aliphatic saturated alcohol and compositions sweetened therewith |
KR100856938B1 (ko) * | 2006-04-28 | 2008-09-05 | 재단법인서울대학교산학협력재단 | 불포화 고급지방산의 페길화 방법 |
KR100801601B1 (ko) * | 2006-06-13 | 2008-02-11 | 씨제이제일제당 (주) | 저칼로리 디저트 젤리 조성물 및 그 제품 |
US20080226773A1 (en) * | 2007-03-14 | 2008-09-18 | Concentrate Manufacturing Company Of Ireland | Beverage Sweetened with Rebaudioside A |
US9877500B2 (en) * | 2007-03-14 | 2018-01-30 | Concentrate Manufacturing Company Of Ireland | Natural beverage products |
US8029846B2 (en) | 2007-03-14 | 2011-10-04 | The Concentrate Manufacturing Company Of Ireland | Beverage products |
US20080226803A1 (en) * | 2007-03-14 | 2008-09-18 | Concentrate Manufacturing Company Of Ireland | Natural flavoring agent for sugar-sweetened tea beverage to taste like high fructose corn syrup-sweetened beverage |
US20080226798A1 (en) * | 2007-03-14 | 2008-09-18 | Concentrate Manufacturing Company Of Ireland | Cola Beverages |
US9314048B2 (en) * | 2007-03-14 | 2016-04-19 | The Concentrate Manufacturing Company Of Ireland | Beverage products with non-nutritive sweetener and bitterant |
US20080226799A1 (en) * | 2007-03-14 | 2008-09-18 | Concentrate Manufacturing Company Of Ireland | Diet Cola Beverages |
US20080226800A1 (en) * | 2007-03-14 | 2008-09-18 | Concentrate Manufacturing Company Of Ireland | Diet cola beverages |
US8277861B2 (en) | 2007-03-14 | 2012-10-02 | Concentrate Manufacturing Company Of Ireland | Beverage products having steviol glycosides and at least one acid |
US8277862B2 (en) | 2007-03-14 | 2012-10-02 | Concentrate Manufacturing Company Of Ireland | Beverage products having steviol glycosides and at least one acid |
US8084073B2 (en) | 2007-03-14 | 2011-12-27 | Concentrate Manufacturing Company Of Ireland | Anisic acid modified steviol glycoside sweetened beverage products |
US8343753B2 (en) | 2007-11-01 | 2013-01-01 | Wake Forest University School Of Medicine | Compositions, methods, and kits for polyunsaturated fatty acids from microalgae |
US20090162487A1 (en) * | 2007-12-21 | 2009-06-25 | The Concentrate Manufacturing Company Of Ireland | Beverage products and flavor systems having a non-sweetening amount of rebaudioside a |
US20090162488A1 (en) * | 2007-12-21 | 2009-06-25 | The Concentrate Manufacturing Company Of Ireland | Beverage products and flavor systems having a non-sweetening amount of monatin |
JP6851594B2 (ja) * | 2017-05-22 | 2021-03-31 | 国立研究開発法人産業技術総合研究所 | 紫外線反射剤組成物及び撥水剤組成物 |
KR102074041B1 (ko) * | 2017-11-28 | 2020-02-05 | 주식회사 이앤티 | Dha 함량이 개선된 돼지고기 삼겹살의 생산을 위한 양돈용 기능성 사료첨가제 및 그 제조방법 |
KR102454544B1 (ko) * | 2020-11-26 | 2022-10-17 | 한국한의약진흥원 | Igf를 다량으로 함유하는 녹용 가수분해물 제조방법 및 이의 용도 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5953427A (ja) * | 1982-09-22 | 1984-03-28 | Eisai Co Ltd | 甘蔗茎皮抽出物および抗脂血剤 |
JPS63283552A (ja) * | 1987-05-15 | 1988-11-21 | Iino Akira | ブラジル原産白甘薯を主体とした健康食品 |
JPH01225461A (ja) * | 1988-03-07 | 1989-09-08 | Eisai Co Ltd | オクタコサナール含有栄養食品 |
JPH0633396B2 (ja) * | 1988-04-23 | 1994-05-02 | 第一製糖株式会社 | 甘蔗脂質成分の抽出法 |
US5267939A (en) * | 1989-01-09 | 1993-12-07 | Life Resonances, Inc. | Techniques for controlling osteoporosis using non-invasive magnetic fields |
JPH04266820A (ja) * | 1991-02-20 | 1992-09-22 | Nippon Oil & Fats Co Ltd | 骨粗鬆症予防治療剤 |
JPH04278061A (ja) * | 1991-03-05 | 1992-10-02 | Suntory Ltd | 栄養食品 |
JPH05310563A (ja) * | 1992-05-15 | 1993-11-22 | Nippon Oil & Fats Co Ltd | カルシトニン産生増強剤 |
EP0585058A1 (en) * | 1992-08-25 | 1994-03-02 | Scotia Holdings Plc | Pharmaceutical compositions containing fatty acids and heparin |
JPH11209324A (ja) * | 1998-01-27 | 1999-08-03 | Sagami Chem Res Center | 抗骨粗鬆症剤及び(r)−8−ヒドロキシ−2,6−ジメチル−2−オクテン酸 |
GB0003310D0 (en) * | 2000-02-15 | 2000-04-05 | Univ Sheffield | Bone formation |
IT1320180B1 (it) * | 2000-12-29 | 2003-11-26 | Hunza Di Marazzita Maria Carme | Preparazioni nutrizionali e terapeutiche dotate di attivita'antiossidante ed in grado di controllare gli eccessi ponderali e |
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2003
- 2003-08-14 AU AU2003257854A patent/AU2003257854A1/en not_active Abandoned
- 2003-08-14 KR KR1020057022541A patent/KR20060022668A/ko not_active Application Discontinuation
- 2003-08-14 CN CNA038265486A patent/CN1791391A/zh active Pending
- 2003-08-14 CA CA002525695A patent/CA2525695A1/en not_active Abandoned
- 2003-08-14 WO PCT/JP2003/010347 patent/WO2004105739A1/ja active Application Filing
- 2003-08-14 EP EP03817077A patent/EP1634588A4/en not_active Withdrawn
- 2003-08-14 JP JP2005500245A patent/JP4423447B2/ja not_active Expired - Fee Related
-
2005
- 2005-11-23 US US11/285,777 patent/US20060127450A1/en not_active Abandoned
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116898032A (zh) * | 2023-07-25 | 2023-10-20 | 广州微特加生物工程有限公司 | 一种含宝藿苷葡聚糖的饲料添加剂及其制备方法和应用 |
CN116898032B (zh) * | 2023-07-25 | 2023-12-01 | 广州微特加生物工程有限公司 | 一种含宝藿苷葡聚糖的饲料添加剂及其制备方法和应用 |
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EP1634588A4 (en) | 2007-04-04 |
AU2003257854A8 (en) | 2005-01-21 |
JP4423447B2 (ja) | 2010-03-03 |
US20060127450A1 (en) | 2006-06-15 |
US20090156686A1 (en) | 2009-06-18 |
EP1634588A1 (en) | 2006-03-15 |
AU2003257854A1 (en) | 2005-01-21 |
KR20060022668A (ko) | 2006-03-10 |
CA2525695A1 (en) | 2004-12-09 |
WO2004105739A1 (ja) | 2004-12-09 |
JPWO2004105739A1 (ja) | 2006-07-20 |
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