CN114599346A - 一种含有醋酸阿比特龙的药物组合物及其制备方法和应用 - Google Patents

一种含有醋酸阿比特龙的药物组合物及其制备方法和应用 Download PDF

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CN114599346A
CN114599346A CN202080065109.7A CN202080065109A CN114599346A CN 114599346 A CN114599346 A CN 114599346A CN 202080065109 A CN202080065109 A CN 202080065109A CN 114599346 A CN114599346 A CN 114599346A
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emulsifier
abiraterone acetate
pharmaceutical composition
capsule
castor oil
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易木林
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Hunan Huize Bio Pharmaceutical Co ltd
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Hunan Huize Bio Pharmaceutical Co ltd
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    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

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Abstract

一种含有醋酸阿比特龙的药物组合物及其制备方法和应用。其中的辅料包含至少一种油相，至少一种乳化剂，和至少一种助乳化剂。所述药物组合物可显著提高生物利用度、制剂的稳定性。所述药物组合物还可进一步制备成胶囊剂。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN202080065109.7A 2019-09-26 2020-05-18 一种含有醋酸阿比特龙的药物组合物及其制备方法和应用 Pending CN114599346A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910916636.3A CN110538150A (zh) 2019-09-26 2019-09-26 一种含有醋酸阿比特龙的药物组合物及其制备方法和应用
CN2019109166363 2019-09-26
PCT/CN2020/090866 WO2021057042A1 (zh) 2019-09-26 2020-05-18 一种含有醋酸阿比特龙的药物组合物及其制备方法和应用

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CN114599346A true CN114599346A (zh) 2022-06-07

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CN202310904468.2A Pending CN116785301A (zh) 2019-09-26 2019-09-26 含醋酸阿比特龙的药物组合物及其制备方法和应用
CN201910916636.3A Pending CN110538150A (zh) 2019-09-26 2019-09-26 一种含有醋酸阿比特龙的药物组合物及其制备方法和应用
CN202080065109.7A Pending CN114599346A (zh) 2019-09-26 2020-05-18 一种含有醋酸阿比特龙的药物组合物及其制备方法和应用

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CN201910916636.3A Pending CN110538150A (zh) 2019-09-26 2019-09-26 一种含有醋酸阿比特龙的药物组合物及其制备方法和应用

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US (1) US20220265682A1 (zh)
EP (1) EP4035657A4 (zh)
JP (1) JP7394974B2 (zh)
CN (3) CN116785301A (zh)
CA (1) CA3149460C (zh)
TW (1) TW202114701A (zh)
WO (1) WO2021057042A1 (zh)

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* Cited by examiner, † Cited by third party
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CN116785301A (zh) * 2019-09-26 2023-09-22 湖南慧泽生物医药科技有限公司 含醋酸阿比特龙的药物组合物及其制备方法和应用
CN111012745A (zh) * 2020-01-06 2020-04-17 深圳海王医药科技研究院有限公司 一种阿比特龙口服乳剂及其制备方法
CN113133983B (zh) * 2020-01-20 2023-12-12 鲁南制药集团股份有限公司 一种治疗***癌的药物组合物
CN113133984A (zh) * 2020-01-20 2021-07-20 鲁南制药集团股份有限公司 一种cyp17抑制剂的制剂
CN113750032B (zh) * 2020-06-01 2024-07-16 成都海博为药业有限公司 一种口服的阿比特龙药物组合物及其制备方法及用途
CN114762693A (zh) * 2020-12-31 2022-07-19 成都海博为药业有限公司 一种载药量高的阿比特龙药物组合物及其制备方法及用途
CN115444817B (zh) * 2021-06-09 2024-05-14 广东西捷药业有限公司 一种纳米醋酸阿比特龙组合物及其制备方法及应用
CN113456588B (zh) * 2021-07-05 2023-01-03 沈阳药科大学 一种醋酸阿比特龙固体自微乳及其制备方法
CN113616614A (zh) * 2021-07-22 2021-11-09 浙江和泽医药科技股份有限公司 一种醋酸阿比特龙软胶囊及其制备方法
WO2023109758A1 (en) * 2021-12-15 2023-06-22 Hunan Huize Biopharma S&T Co., Ltd Abiraterone acetate-containing composition and application thereof
CN114306236B (zh) * 2021-12-15 2022-10-21 湖南慧泽生物医药科技有限公司 用于负载醋酸阿比特龙的自微乳体系及组合物和应用

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WO2014009434A1 (en) * 2012-07-11 2014-01-16 Sandoz Ag Self-microemulsifying drug delivery system of abiraterone or abiraterone acetate
CN103813794A (zh) * 2011-07-18 2014-05-21 拓凯制药公司 用于治疗***癌的新型组合物及方法
CN105055314A (zh) * 2015-09-28 2015-11-18 杭州安德科技有限公司 一种阿比特龙的口腔喷雾剂及其使用和制备方法
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CN107468650A (zh) * 2016-10-09 2017-12-15 郑州泰丰制药有限公司 一种厄贝沙坦自乳化软胶囊及其制备方法
CN106821977A (zh) * 2017-01-22 2017-06-13 福建医科大学 茶油纳米乳剂及其制备方法
CN116785301A (zh) * 2019-09-26 2023-09-22 湖南慧泽生物医药科技有限公司 含醋酸阿比特龙的药物组合物及其制备方法和应用

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WO2014009434A1 (en) * 2012-07-11 2014-01-16 Sandoz Ag Self-microemulsifying drug delivery system of abiraterone or abiraterone acetate
CN107073127A (zh) * 2014-06-19 2017-08-18 索露奥公司 亲脂性化合物的固体口服剂型
CN105055314A (zh) * 2015-09-28 2015-11-18 杭州安德科技有限公司 一种阿比特龙的口腔喷雾剂及其使用和制备方法
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EP4035657A4 (en) 2022-11-16
CA3149460A1 (en) 2021-04-01
CN110538150A (zh) 2019-12-06
EP4035657A1 (en) 2022-08-03
US20220265682A1 (en) 2022-08-25
JP7394974B2 (ja) 2023-12-08
CA3149460C (en) 2024-05-21
TW202114701A (zh) 2021-04-16
WO2021057042A1 (zh) 2021-04-01
CN116785301A (zh) 2023-09-22
JP2022549729A (ja) 2022-11-28

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