WO2021057042A1 - 一种含有醋酸阿比特龙的药物组合物及其制备方法和应用 - Google Patents
一种含有醋酸阿比特龙的药物组合物及其制备方法和应用 Download PDFInfo
- Publication number
- WO2021057042A1 WO2021057042A1 PCT/CN2020/090866 CN2020090866W WO2021057042A1 WO 2021057042 A1 WO2021057042 A1 WO 2021057042A1 CN 2020090866 W CN2020090866 W CN 2020090866W WO 2021057042 A1 WO2021057042 A1 WO 2021057042A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- emulsifier
- abiraterone acetate
- pharmaceutical composition
- castor oil
- capsule
- Prior art date
Links
- UVIQSJCZCSLXRZ-UBUQANBQSA-N abiraterone acetate Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CC[C@@H](CC4=CC[C@H]31)OC(=O)C)C=C2C1=CC=CN=C1 UVIQSJCZCSLXRZ-UBUQANBQSA-N 0.000 title claims abstract description 179
- 229960004103 abiraterone acetate Drugs 0.000 title claims abstract description 151
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- 229940079593 drug Drugs 0.000 title claims abstract description 44
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- RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 claims description 14
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Images
Classifications
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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Definitions
- the invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition containing abiraterone acetate, and a preparation method and application thereof.
- Abiraterone acetate is a white to off-white, non-hygroscopic crystalline powder; chemically named (3 ⁇ )-17-(3-pyridyl)androsta-5,16-dien-3-yl acetate, Its molecular formula is C 26 H 33 NO 2 .
- Abiraterone acetate is converted into androgen biosynthesis inhibitor abiraterone in the body, which inhibits 17 ⁇ -hydroxylase/C17,20-lyase (CYP17). It can be used in combination with prednisone for the treatment of patients with metastatic and refractory prostate cancer (CRPC) who have previously received docetaxel-containing chemotherapy.
- CRPC metastatic and refractory prostate cancer
- abiraterone acetate is a lipophilic compound, its octanol-water partition coefficient is 5.12 (LogP), the pKa of aromatic nitrogen is 5.19, it is almost insoluble in water (less than 0.01mg/ml), and its permeability is poor. It is a four-type BCS drug with extremely low bioavailability when absorbed orally.
- Zytiga the original research drug of abiraterone acetate
- abiraterone acetate is a tablet.
- Each tablet of Zytiga contains 250mg abiraterone acetate.
- Inactive ingredients include: colloidal silicon dioxide, croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone and dodecane Sodium Sulfate.
- the oral bioavailability of Zytiga is very low (less than 10%), with a single dose of up to 1000 mg, but only less than 10% of the drug can exert its efficacy.
- abiraterone acetate orally has a good effect in the treatment of advanced prostate cancer, its low solubility and poor permeability have brought obstacles to formulation design.
- Yonsa Sun Pharmaceutical Industries Ltd of India uses SoluMatrix microparticle technology to manufacture Yonsa to provide an improved abiraterone acetate tablet that can promote the dissolution of abiraterone acetate and double the oral bioavailability of the original drug Zytiga.
- the dose of Yonsa was reduced to 500mg, it only changed the crystal form and size of the drug, increased the dissolution rate of the drug, and failed to increase the permeability of abiraterone acetate to gastrointestinal epithelial cells. Therefore, the oral bioavailability of Yonsa is still Very low.
- Patent document CN107278152A relates to an abiraterone acetate complex, its preparation method and a pharmaceutical composition containing them, which comprises 5-40% by weight of abiraterone acetate and 5-80% by weight of polyvinylcaprolactam-polyacetic acid Vinyl ester-polyethylene glycol graft copolymer, 0.1-50% by weight sodium deoxycholate.
- the compound can reduce the effect of food and give up the requirement of fasting medication, and can increase the oral bioavailability by up to 5 times, but the preparation process of the compound preparation is complicated.
- the purpose of the present invention is to provide a pharmaceutical composition that can significantly improve the oral absorption of abiraterone acetate.
- abiraterone acetate Bittrane has low solubility in various solvents and emulsifiers. Although the drug can quickly dissolve at high temperature, it is easy to precipitate crystals and lose its self-emulsifying properties when stored at room temperature.
- the dosage of abiraterone acetate is large, and the self-emulsifying solution that needs to be designed must have a high drug content and can exist stably at room temperature.
- the above technical difficulties have become a major bottleneck in the design of the formulation.
- whether the self-emulsifying solution can spontaneously form a uniform and stable nanoemulsion with water is another difficulty in the design of the formulation.
- a pharmaceutical composition containing abiraterone acetate including (consisting of the following components):
- Active ingredient Abiraterone acetate
- At least one emulsifier At least one emulsifier
- the concentration of the abiraterone acetate is between 20-100 mg/mL.
- the pharmaceutical composition of the present invention is a solution, which is easy to form a nanoemulsion with water, can increase the dissolution of the medicine, promote absorption, and improve the bioavailability.
- the auxiliary material of the pharmaceutical composition provided by the present invention can be used as a carrier for hydrophobic, difficult to absorb or easily hydrolyzed drugs.
- the gastrointestinal fluid spontaneously disperses under gastrointestinal peristalsis to form O/W nanoemulsion (oil-in-water nanoemulsion).
- O/W nanoemulsion oil-in-water nanoemulsion
- the formed nanoemulsion has a small particle size, increases the penetration of intestinal epithelial cells, and can significantly improve the bioavailability of drugs.
- the self-emulsifying solution has higher stability and can meet the requirements of long-term storage. At the same time, it can also be directly packed into soft capsules or hard capsules.
- the abiraterone acetate accounts for 2-20% of the total mass of the pharmaceutical composition, preferably 5-15%, more preferably 5-10%.
- the pharmaceutical composition containing abiraterone acetate according to the present invention has at least one of the following properties:
- composition containing abiraterone acetate according to the present invention preferably,
- the oil phase is selected from one of hydrogenated castor oil, glyceryl monooleate, propylene glycol monocaprylate, corn oil, soybean oil, medium-chain triglycerides or ethyl oleate, glyceryl monolinoleate or At least two.
- the oil phase accounts for 20-50%, preferably 20-45%, more preferably 25-45% of the total mass of the pharmaceutical composition containing abiraterone acetate;
- the oil phase is selected from one or at least two of glycerol monolinoleate, medium-chain triglycerides, hydrogenated castor oil, and glycerol monooleate.
- composition containing abiraterone acetate according to the present invention preferably,
- the emulsifier is selected from polyoxyethylene castor oil EL35, polyoxyethylene 40 hydrogenated castor oil, Span 80, Tween 80, polyethylene glycol-15 hydroxystearate (Solutol), polyethylene caprolactam-poly One or at least two of vinyl acetate-polyethylene glycol graft copolymer (Soluplus).
- the emulsifier accounts for 20-70% of the total mass of the pharmaceutical composition, preferably 20-50%, more preferably 20-35%;
- polyoxyethylene castor oil EL35 Preferably selected from one or at least two of polyoxyethylene castor oil EL35, polyoxyethylene 40 hydrogenated castor oil, Span 80, polyethylene caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus) More preferably, the emulsifier is polyoxyethylene castor oil EL35 or polyoxyethylene 40 hydrogenated castor oil.
- composition containing abiraterone acetate according to the present invention preferably,
- the co-emulsifier is selected from one or at least two of ethanol, propylene glycol, polyethylene glycol 400, and diethylene glycol monoethyl ether.
- the co-emulsifier accounts for 20-80% of the total mass of the pharmaceutical composition containing abiraterone acetate, preferably 20-60%, more preferably 20-50%, still more preferably 20-45%.
- the co-emulsifier is selected from the combination of propylene glycol and ethanol, and the content of the combination is more preferably 20-30%, or the content of diethylene glycol monoethyl ether is more preferably 25-45%.
- composition of the present invention the total content of all clearly listed components is less than or equal to 100% by mass.
- the inventor of the present invention unexpectedly discovered that the specific co-emulsifier of the present invention, together with the oil phase and emulsifier, forms a uniform and transparent solution, which can be used as a carrier for hydrophobic, difficult to absorb or easily hydrolyzed drugs.
- the pharmaceutical composition containing the co-emulsifier of the present invention will spontaneously disperse to form O/W nanoemulsion (oil-in-water nanoemulsion) under gastrointestinal peristalsis after being taken orally.
- the formed nanoemulsion has a small particle size, which increases the penetration of intestinal epithelial cells, which can significantly promote absorption and improve bioavailability.
- the pharmaceutical composition of the present invention can also significantly reduce the influence of food on the absorption of abiraterone acetate, reduce the difference between pre-meal and post-meal, so that the medicine can be taken under both fasting and full stomach conditions, reducing the restriction on the time of taking the medicine.
- the pharmaceutical composition containing abiraterone acetate includes the following mass percentage components (consisting of the following components):
- oil phase is one or two of hydrogenated castor oil and glycerol monooleate;
- the emulsifier is polyoxyethylene castor oil EL35 or polyoxyethylene 40 hydrogenated castor oil;
- the co-emulsifier is a mixture of ethanol and propylene glycol
- oil phase is one or two of hydrogenated castor oil and glycerol monooleate;
- the emulsifier is one or two of polyoxyethylene castor oil EL35 and Span 80;
- the co-emulsifier is a mixture of ethanol and propylene glycol
- oil phase is one or two of monolinoleic acid glyceride and medium chain triglyceride;
- the emulsifier is polyoxyethylene castor oil EL35 or polyoxyethylene 40 hydrogenated castor oil;
- the co-emulsifier is diethylene glycol monoethyl ether.
- composition containing abiraterone acetate according to the present invention preferably,
- the adjuvant may further include one or two of antioxidants and preservatives, and the antioxidants or preservatives account for 0.005%-0.3% (preferably 0.005%-0.1%) of the total mass of the pharmaceutical composition. %);
- the antioxidant is selected from one or a combination of tert-butyl p-hydroxyanisole (BHA) and butylated hydroxytoluene (BHT).
- the pharmaceutical composition containing abiraterone acetate preferably includes the following components (consisting of the following components) in terms of mass percentage:
- oil phase is hydrogenated castor oil and glycerol monooleate
- the emulsifier is one or two of polyoxyethylene castor oil EL35 or polyoxyethylene 40 hydrogenated castor oil;
- the co-emulsifier is ethanol and propylene glycol
- oil phase is one or two of monolinoleic acid glyceride and medium chain triglyceride;
- the emulsifier is polyoxyethylene castor oil EL35 or polyoxyethylene 40 hydrogenated castor oil;
- co-emulsifier is diethylene glycol monoethyl ether
- oil phase is one or two of hydrogenated castor oil and glycerol monooleate;
- the emulsifier is one or two of polyoxyethylene castor oil EL35 and Span 80;
- the co-emulsifier is a mixture of ethanol and propylene glycol
- the pharmaceutical composition containing abiraterone acetate includes (consisting of the following components):
- composition containing abiraterone acetate according to the present invention preferably,
- the active ingredient also includes: prednisone.
- the pharmaceutical composition of the present invention has excellent curative effect as a medicine, especially has excellent inhibitory activity on 17 ⁇ -hydroxylase/C17,20-lyase (CYP17). Because the pharmaceutical composition of the present invention can significantly reduce pre-meal and post-meal differences and improve oral bioavailability, it can be used in combination with prednisone for metastatic and refractory prostate cancer (CRPC) that has received previous docetaxel-containing chemotherapy The treatment of patients, and the effect is outstanding.
- CRPC metastatic and refractory prostate cancer
- the pharmaceutical composition containing abiraterone acetate provided by the present invention can be used alone to treat diseases, for example, to treat diseases including but not limited to prostate cancer.
- the pharmaceutical composition provided by the present invention can be administered in the following ways (for example but not limited to):
- the effective amount of abiraterone acetate per administration is 25mg-200mg; more preferably 50mg-150mg, further preferably 75mg-100mg.
- the present invention also provides the application of the pharmaceutical composition in the preparation of pharmaceutical preparations; preferably, the application in the preparation of pharmaceutical preparations for the treatment of prostate cancer; more preferably, the prostate cancer is selected from the group consisting of metastatic castration-resistant prostate cancer and One or two of the high-risk metastatic castration-sensitive prostate cancers.
- the present invention also provides a pharmaceutical preparation containing the pharmaceutical composition described in any one of the above.
- the pharmaceutical preparation is a capsule.
- the capsule of the present invention includes the pharmaceutical composition containing abiraterone acetate described in any one of the above and a capsule shell; the capsule shells are all well-known hard capsules and/or soft capsule materials, such as hard gelatin Both capsules and gelatin soft capsules can be purchased or prepared through commercial channels, and are not specifically limited herein.
- the abiraterone acetate contained in each capsule is within 100 mg.
- the present invention defines that the abiraterone acetate capsules are based on abiraterone acetate and have a single oral dose of 50-200 mg.
- the present invention also provides a drug combination (mode), including:
- the pharmaceutical combinations (modes) described herein include but are not limited to the use of prednisone as one of the active ingredients, the pharmaceutical compositions or capsules and prednisone before and after taking, and the like. It can be performed according to the conventional operation in the field.
- the present invention further provides the use of the abiraterone acetate capsule described in any one of the above technical solutions and/or the drug combination described in any one of the technical solutions in the preparation of a medicament for the treatment of prostate cancer;
- the prostate cancer is selected from one or both of metastatic castration-resistant prostate cancer and metastatic high-risk castration-sensitive prostate cancer.
- the present invention also provides a method for preparing a pharmaceutical composition containing abiraterone acetate according to any one of the above technical solutions. After the oil phase, the emulsifier and the active ingredient are mixed, the emulsification aid is added. Agents (which may also include antioxidants and/or preservatives) are available.
- the preparation method may include the steps of mechanical stirring, emulsification, and ultrasound.
- the preferred technical solutions are as follows:
- the preparation method of the pharmaceutical preparations of the present invention can also be operated by those skilled in the art according to conventional methods in the art.
- the preferred technical solutions when preparing capsules are given here, as follows:
- the pharmaceutical composition containing abiraterone acetate is prepared according to the aforementioned method; the pharmaceutical composition is sealed in a soft capsule or a hard capsule; preferably, each capsule contains 0.5-1 ml of the pharmaceutical composition.
- the concentration of abiraterone acetate can be controlled at 50-100 mg/mL, and a single oral dose of 75-100 mg.
- biologically related media such as SGF, SGF, FessiF and FassiF media
- gastrointestinal fluid When mixed with water, biologically related media (such as SGF, SGF, FessiF and FassiF media) or gastrointestinal fluid, it can spontaneously form O/W nanoemulsions with a particle size of less than 250nm, high clarity, uniform particle size, and stable properties;
- the contents stored at room temperature can exist in the form of a stable solution; even under the conditions of influencing factors (40°C ⁇ 2°C, or relative humidity 90%), the content of the pharmaceutical composition of the present invention is stable.
- the pharmaceutical composition can be further prepared into a capsule, which is stable and has a uniform texture of the content.
- the present invention also relates to a treatment method for prostate cancer, which includes administering the aforementioned pharmaceutical composition containing abiraterone acetate or abiraterone acetate capsules.
- the single administration dose is 25mg-200mg based on abiraterone acetate; more preferably 50mg-200mg; still more preferably 50mg-150mg, still more preferably 75mg-100mg.
- the pharmaceutical composition or capsule can be administered before or after a meal.
- the prostate cancer is selected from one or both of metastatic castration-resistant prostate cancer and metastatic high-risk castration-sensitive prostate cancer.
- Figure 1 is a particle size distribution diagram of the abiraterone acetate capsules in Example 1 after the contents of the abiraterone acetate capsules are microemulsion in water.
- Figure 2 is a particle size distribution diagram of the abiraterone acetate capsules in Example 2 after the contents of the abiraterone acetate capsules are microemulsion in water.
- Fig. 3 is a particle size distribution diagram of the abiraterone acetate capsules in Example 8 after the contents of the abiraterone acetate capsules are microemulsion in water.
- Fig. 4 is a drug-time curve chart of the fasting test of tablets and capsules in Test Example 4.
- Fig. 5 is a drug-time curve chart of the capsule fasting and postprandial test in Test Example 4.
- This embodiment provides a pharmaceutical composition containing abiraterone acetate, which includes the following components:
- This embodiment further provides an abiraterone acetate capsule, which uses the above-mentioned pharmaceutical composition as a content, and the content is filled in a capsule shell.
- the preparation method provided is as follows:
- This embodiment provides a pharmaceutical composition containing abiraterone acetate, which includes the following components:
- This embodiment further provides an abiraterone acetate capsule, which uses the above-mentioned pharmaceutical composition as a content, and the content is filled in a capsule shell.
- the preparation method provided is as follows:
- Span 80 hydrogenated castor oil, glycerol monooleate, polyoxyethylene castor oil EL35, then add abiraterone acetate, use mechanical stirring (300rpm), stir for 25min, make it fully dissolved, then add BHA, BHT, propylene glycol It is mixed with ethanol to form a transparent and uniform self-emulsifying solution, which is filled in a soft capsule or sealed in a hard capsule for storage under nitrogen protection.
- This embodiment provides a pharmaceutical composition containing abiraterone acetate, which includes the following components:
- This embodiment further provides an abiraterone acetate capsule, which uses the above-mentioned pharmaceutical composition as a content, and the content is filled in a capsule shell.
- the preparation method provided is as follows:
- This embodiment provides a pharmaceutical composition containing abiraterone acetate, which includes the following components:
- This embodiment further provides an abiraterone acetate capsule, which uses the above-mentioned pharmaceutical composition as a content, and the content is filled in a capsule shell.
- the preparation method provided is as follows:
- This embodiment provides a pharmaceutical composition containing abiraterone acetate, which includes the following components:
- This embodiment further provides an abiraterone acetate capsule, which uses the above-mentioned pharmaceutical composition as a content, and the content is filled in a capsule shell.
- the preparation method provided is as follows:
- This embodiment provides a pharmaceutical composition containing abiraterone acetate, which includes the following components:
- This embodiment further provides an abiraterone acetate capsule, which uses the above-mentioned pharmaceutical composition as a content, and the content is filled in a capsule shell.
- the preparation method is also provided: measure Tween 80, corn oil, glycerol monooleate, polyoxyethylene 40 hydrogenated castor oil, weigh abiraterone acetate and add it, make it fully fused, add propylene glycol and ethanol, and water bath Under heating conditions, a transparent and uniform solution is formed. When it is lowered to room temperature, the homogeneous phase is destroyed and the drug crystallizes.
- This embodiment provides a pharmaceutical composition containing abiraterone acetate, which includes the following components:
- This embodiment further provides an abiraterone acetate capsule, which uses the above-mentioned pharmaceutical composition as a content, and the content is filled in a capsule shell.
- the preparation method is also provided: measure Tween 80, polyoxyethylene 40 hydrogenated castor oil, hydrogenated castor oil, glycerol monooleate, polyoxyethylene castor oil EL35, and then add abiraterone acetate to fully dissolve it Propylene glycol and ethanol are added to form a transparent and uniform self-emulsifying solution, which is filled in soft capsules or sealed in hard capsules under nitrogen protection for storage.
- This embodiment provides a pharmaceutical composition containing abiraterone acetate, which includes the following components:
- This embodiment further provides an abiraterone acetate capsule, which uses the above-mentioned pharmaceutical composition as a content, and the content is filled in a capsule shell.
- the preparation method is also provided: weigh out Span 80, Solutol, hydrogenated castor oil, glyceryl monooleate, polyoxyethylene castor oil EL35, and then add abiraterone acetate to make it fully dissolved, then add propylene glycol and ethanol and wait for it.
- a transparent and uniform self-emulsifying solution is formed, which is filled in a soft capsule or sealed in a hard capsule for storage under nitrogen protection.
- This embodiment provides a pharmaceutical composition containing abiraterone acetate, which includes the following components:
- This embodiment further provides an abiraterone acetate capsule, which uses the above-mentioned pharmaceutical composition as a content, and the content is filled in a capsule shell.
- the preparation method is also provided: weigh out Span 80, hydrogenated castor oil, glycerol monooleate, polyoxyethylene castor oil EL35, and then add abiraterone acetate to make it fully dissolved and then add propylene glycol and ethanol until it becomes transparent
- the homogeneous self-emulsifying solution is filled in soft capsules or sealed in hard capsules under nitrogen protection for storage.
- Example 3 The other conditions are the same as in Example 3 except that diethylene glycol monoethyl ether is replaced from 4.8 mL to 1.6 mL.
- This test example provides the dissolution test of the abiraterone acetate capsule and the original drug Zytiga tablet provided in Examples 1-4.
- Test method According to the "U.S. Pharmacopoeia" abiraterone acetate dissolution test method, at 37°C, 900mL release medium 1, 50rpm conditions, respectively, the abiraterone acetate capsules (prepared in Examples 1, 2, 3) and the original drug Zytiga tablets were tested for dissolution.
- a phosphate buffer solution with a pH value of 4.5 is prepared by the following method: 56.5 mM sodium dihydrogen phosphate is added to water, and the pH value is adjusted to 4.5 with sodium hydroxide or phosphoric acid.
- Example 1 Example 2
- Example 3 Example 4 5 twenty two 73 80 74 75 10 42 93 97 91 90 15 64 96 99 97 96 20 71 98 99 99 99 97 30 89 99 97 99 99 45 91 98 99 99 99 99
- Example 1 Example 2
- Example 3 Example 4 5 0 86 72 70 75 10 0 95 84 84 82 15 1 99 92 90 97 20 1 98 96 94 96 30 2 99 97 99 97 45 2 97 99 99 99 99
- Table 1 and Table 2 show that the abiraterone acetate capsules of the present invention (Examples 1, 2, 3, 4) dissolve almost completely in medium 1 within 15 minutes, while the marketed abiraterone acetate tablet Zytiga 45 minutes still
- the abiraterone acetate capsules of the present invention basically dissolve completely in medium 2, but the marketed abiraterone acetate tablet Zytiga has very low dissolution.
- the abiraterone acetate capsule of the present invention can effectively improve the dissolution of abiraterone acetate under both USP and non-UPS conditions, which will help improve the oral bioavailability of abiraterone acetate and reduce Individual Differences.
- This test example provides the stability test of the abiraterone acetate capsules provided in Examples 1-9.
- the pharmaceutical composition formed by the specific emulsifier, oil phase and co-emulsifier of the present invention and abiraterone acetate has good physical stability.
- 20%-80% (mass percentage relative to the total mass of the composition) of specific co-emulsifiers and specific emulsifiers polyoxyethylene castor oil EL35, polyoxyethylene 40 hydrogenated castor oil, Span 80, poly The combination of ethylene glycol-15 hydroxystearate) achieves significantly better physical stability.
- the mass percentage of the co-emulsifier is preferably 60% or less, especially 20%-60%.
- This test example provides the self-emulsifying ability and particle size test of the pharmaceutical compositions provided in Examples 1-9.
- Example 1-9 The pharmaceutical composition prepared in Example 1-9 was added to purified water, and the appearance properties were observed after slight shaking, and the particle size of the formed emulsion was measured by a nanometer particle size meter, as shown in Table 5-1.
- This test example also provides the detection of the stability of the nanoemulsion obtained after emulsifying the pharmaceutical composition of Examples 1-9, and the detection method is as follows:
- Figure 1 is the particle size distribution diagram of the abiraterone acetate capsule contents in water after microemulsion in Example 1
- Figure 2 is the abiraterone acetate capsule content in water after microemulsion in Example 2
- Figure 3 shows the particle size distribution of the abiraterone acetate capsules in Example 8 after the contents of the abiraterone acetate capsules were microemulsion in water.
- This test example provides the pharmacokinetic test of Example 1 and the original drug Zytiga of abiraterone acetate.
- the experimental design is divided into fasting test and postprandial test.
- Fasting test Fasting for 10 hours before the test, giving the drug on an empty stomach, and feeding it 4 hours after the drug.
- Postprandial test Fasting for 10 hours before the test, and administering after feeding a high-fat meal (feeding and administration are completed within 30 minutes).
- the test tablet is the original research drug Zytiga of abiraterone acetate, and a single tablet contains 250mg of abiraterone acetate;
- the test capsule is the abiraterone acetate capsule provided in Example 1, and a single capsule contains 50 mg of abiraterone acetate.
- Sampling design 15min, 30min, 1h, 1.5h, 2.0h, 2.5h, 3h, 4h, 6h, 8h, 10h, 12h, 24h after administration, collect 2mL blood samples, and centrifuge to separate plasma.
- T1 is the fasting test-the original drug Zytiga group (labeled as fasting tablet group in Figure 4)
- T2 is the fasting test-abiraterone acetate capsule group (labeled as fasting capsules in Figure 4 and Figure 5) Group)
- T3 is a postprandial test-abiraterone acetate capsule group (marked as a postprandial capsule group in Figure 5).
- T1/2 is the half-life of the drug
- Tmax is the peak time
- Cmax is the maximum plasma concentration (peak concentration)
- AUClast is the AUC (drug-time curve area) of the duration from the start of administration to the last point.
- Fig. 4 is the drug-time curve of the abiraterone acetate capsule 50mg (T2) in Example 1 in the fasting test and the abiraterone acetate capsule (T3) taken after a high-fat meal in the fasting state of beagle dogs.
- T1/2 is the half-life of the drug
- Tmax is the peak time
- Cmax is the maximum plasma concentration (peak concentration)
- AUClast is the AUC (drug-time curve area) of the duration from the start of administration to the last point.
- Fig. 5 is the drug-time curve of 50 mg abiraterone acetate capsule in Example 1 in the pre-meal (T2) and post-meal (T3) states of beagle dogs in the postprandial test.
- the abiraterone acetate capsule provided by the present invention can reduce pre- and post-prandial differences .
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Abstract
Description
取样点/min | Zytiga | 实施例1 | 实施例2 | 实施例3 | 实施例4 |
5 | 22 | 73 | 80 | 74 | 75 |
10 | 42 | 93 | 97 | 91 | 90 |
15 | 64 | 96 | 99 | 97 | 96 |
20 | 71 | 98 | 99 | 99 | 97 |
30 | 89 | 99 | 97 | 99 | 99 |
45 | 91 | 98 | 99 | 99 | 99 |
取样点/min | Zytiga | 实施例1 | 实施例2 | 实施例3 | 实施例4 |
5 | 0 | 86 | 72 | 70 | 75 |
10 | 0 | 95 | 84 | 84 | 82 |
15 | 1 | 99 | 92 | 90 | 97 |
20 | 1 | 98 | 96 | 94 | 96 |
30 | 2 | 99 | 97 | 99 | 97 |
45 | 2 | 97 | 99 | 99 | 99 |
Claims (10)
- 一种含有醋酸阿比特龙的药物组合物,其特征在于,包括:活性成分:醋酸阿比特龙;辅料:至少一种油相;至少一种乳化剂;和至少一种助乳化剂。
- 根据权利要求1所述的药物组合物,其特征在于,基于所述辅料的总体积,所述醋酸阿比特龙的浓度在20-100mg/mL之间;和/或,所述醋酸阿比特龙的质量占所述药物组合物的总质量的2-20%。
- 根据权利要求1或2所述的药物组合物,其特征在于,所述油相选自单亚油酸甘油酯、氢化蓖麻油、单油酸甘油酯、丙二醇单辛酸酯、玉米油、大豆油、中链甘油三酯或油酸乙酯中的一种或至少两种;优选地,所述的油相占所述含有醋酸阿比特龙的药物组合物的总质量的20-50%;和/或,所述的乳化剂选自聚氧乙烯蓖麻油EL35、司盘80、吐温80、聚乙二醇-15羟基硬脂酸酯Solutol、聚乙烯己内酰胺-聚乙酸乙烯酯-聚乙二醇接枝共聚物Soluplus、聚氧乙烯40氢化蓖麻油中的一种或至少两种;优选地,所述的乳化剂的质量占所述药物组合物的总质量的20-70%;和/或,所述的助乳化剂选自乙醇、丙二醇、聚乙二醇400、二乙二醇单乙基醚中的一种或至少两种;优选地,所述的助乳化剂的质量占所述药物组合物的总质量的20-80%。
- 根据权利要求1-3任一项所述的药物组合物,其特征在于,按照质量百分含量计,基于所述药物组合物的总质量,包括如下质量百分比的组分:2-20%醋酸阿比特龙;20-50%油相,所述油相为氢化蓖麻油和单油酸甘油酯中的一种或两种;20-60%乳化剂,所述乳化剂为聚氧乙烯蓖麻油EL35或聚氧乙烯40氢化蓖麻油;20-30%助乳化剂,所述助乳化剂为乙醇和丙二醇的混合物;或,2-20%醋酸阿比特龙;20-50%油相,所述油相为氢化蓖麻油、单油酸甘油酯中的一种或两种;20-60%乳化剂,所述乳化剂为聚氧乙烯蓖麻油EL35、司盘80中的一种或两种;20-30%助乳化剂,所述助乳化剂为乙醇和丙二醇的混合物;或,2-20%醋酸阿比特龙;20-50%油相,所述油相为单亚油酸甘油酯和中链甘油三酯中的一种或两种;20-70%乳化剂,所述乳化剂为聚氧乙烯蓖麻油EL35或聚氧乙烯40氢化蓖麻油;20-80%助乳化剂,所述助乳化剂为二乙二醇单乙基醚。
- 根据权利要求1-4任一项所述的药物组合物,其特征在于,所述辅料还包括:抗氧剂、防腐剂中的一种或两种;所述抗氧剂或防腐剂占所述药物组合物的总质量的0.005%-0.1%;优选地,所述抗氧剂选自叔丁基对羟基茴香醚BHA、丁羟基甲苯BHT中的一种或两种。
- 权利要求1-5任一项所述的药物组合物的制备方法,其特征在于,包括如下步骤:将所述油相、所述乳化剂和所述活性成分混合后,再加入所述助乳化剂 即得;优选地,包括如下步骤:对所述油相及所述乳化剂搅拌均一后加入醋酸阿比特龙,在避光条件下超声10-20min,以100-400rpm的速度进行机械搅拌10-30min,最后加入所述助乳化剂混匀,即得。
- 权利要求1-5任一项所述的药物组合物在制备药物制剂中的应用;优选地,在制备治疗***癌的药物制剂中的应用;更优选,所述***癌选自转移去势抵抗性***癌和转移性高风险去势敏感型***癌中的一种或两种。
- 一种醋酸阿比特龙胶囊剂,包括内容物和胶囊壳,其特征在于,以权利要求1-5任一项所述的药物组合物作为内容物;优选地,所述胶囊壳由硬胶囊或软胶囊材料制成;更优选地,基于醋酸阿比特龙计,单次口服剂量为25-200mg。
- 一种药物组合,其特征在于,包括:权利要求1-5任一项所述的药物组合物、权利要求8所述的醋酸阿比特龙胶囊剂中的一种,以及***。
- 权利要求8所述的醋酸阿比特龙胶囊剂、和/或权利要求9所述的药物组合在制备治疗***癌的药物中的应用;优选地,所述***癌选自转移去势抵抗性***癌和转移性高风险去势敏感型***癌中的一种或两种。
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CN111012745A (zh) * | 2020-01-06 | 2020-04-17 | 深圳海王医药科技研究院有限公司 | 一种阿比特龙口服乳剂及其制备方法 |
CN113133984A (zh) * | 2020-01-20 | 2021-07-20 | 鲁南制药集团股份有限公司 | 一种cyp17抑制剂的制剂 |
CN113133983B (zh) * | 2020-01-20 | 2023-12-12 | 鲁南制药集团股份有限公司 | 一种治疗***癌的药物组合物 |
CN113750032A (zh) * | 2020-06-01 | 2021-12-07 | 成都海博为药业有限公司 | 一种口服的阿比特龙药物组合物及其制备方法及用途 |
CN114762693A (zh) * | 2020-12-31 | 2022-07-19 | 成都海博为药业有限公司 | 一种载药量高的阿比特龙药物组合物及其制备方法及用途 |
CN115444817B (zh) * | 2021-06-09 | 2024-05-14 | 广东西捷药业有限公司 | 一种纳米醋酸阿比特龙组合物及其制备方法及应用 |
CN113456588B (zh) * | 2021-07-05 | 2023-01-03 | 沈阳药科大学 | 一种醋酸阿比特龙固体自微乳及其制备方法 |
CN114306236B (zh) * | 2021-12-15 | 2022-10-21 | 湖南慧泽生物医药科技有限公司 | 用于负载醋酸阿比特龙的自微乳体系及组合物和应用 |
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