CN109091633B

CN109091633B - Composition for treating recurrent respiratory tract infection of children and preparation method and application thereof

Info

Publication number: CN109091633B
Application number: CN201811249802.0A
Authority: CN
Inventors: 查奇士
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-10-25
Filing date: 2018-10-25
Publication date: 2021-08-03
Anticipated expiration: 2038-10-25
Also published as: CN109091633A

Abstract

The invention discloses a composition for treating recurrent respiratory tract infection of children, a preparation method and application thereof, and solves the problems of uncertain effect and poor safety in the prior art. The invention also provides a preparation method of the composition. The composition is prepared from the following raw materials in parts by weight: 5-50 parts of ginseng, 10-80 parts of Chinese yam, 10-60 parts of endothelium corneum gigeriae galli, 5-60 parts of dried orange peel, 5-30 parts of honey-fried licorice root, 5-40 parts of radix peucedani and 20-120 parts of bamboo juice. The invention has scientific formula and reasonable proportion, all the components have synergistic effect, the effect of treating the recurrent respiratory tract infection of the children is played together, and the invention is safe to take for a long time.

Description

Composition for treating recurrent respiratory tract infection of children and preparation method and application thereof

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a composition for treating recurrent respiratory tract infection of children, and a preparation method and application thereof.

Background

Recurrent respiratory tract infection is a common disease in pediatric clinical, and the incidence rate reaches about 20 percent. It refers to respiratory tract infection with frequent upper respiratory tract infection or lower respiratory tract infection frequency within 1 year and exceeding a certain range. Different age diagnosis standards are different, repeated upper respiratory tract infection is caused for more than 7 times per year for infants within 2 years of age, more than 6 times per year for children 3-5 years of age, and more than 5 times per year for children over 6 years of age; repeated lower respiratory tract infection can be diagnosed more than 3 times/year for infants within 2 years of age, more than 2 times/year for children 3-5 years of age, and more than 2 times/year for children over 6 years of age.

There are many causes of recurrent respiratory tract infection in children. The infant is in the growth stage, the development of each organ is not mature, various regulation functions are not stable, the susceptibility to diseases is strong, and the stress function is low. After the infant has suffered from the disease, the phlegm of the fruit is not smoothly discharged, the inflammation can be prevented from being resolved, even the phlegm becomes a culture medium for bacterial reproduction in vivo, secondary infection is caused, and the disease condition is aggravated. Food stagnation is a pathological product and a pathogenic factor, and can induce recurrent respiratory tract infection of children.

In the prior art, the recurrent respiratory tract infection of children is treated by adopting a bronchodilator. However, the development of the bronchial smooth muscle and the nervous system of children is not mature enough, the sensitivity to the bronchodilator is poor, the toxic reaction is strong, and particularly, western medicines of aminophylline and Chinese ephedra are very easy to cause the excitability increase symptoms of the nervous system, such as dysphoria, stuffiness in the organs, irritability and even convulsion of children.

Besides, bitter apricot seed, pinellia tuber, asarum herb, dried ginger, aconite root, realgar, diuretic and other medicines are used for treating the recurrent respiratory tract infection of the children. However, bitter apricot seeds are toxic, and a small amount of hydrocyanic acid is generated after amygdalin is decomposed, so that the bitter apricot seeds can resist the cough center to play a role in relieving cough and asthma, but sputum is not easy to discharge. Diuretic such as ze Xie and Zhu Ling has strong diuretic effect, and can damage body fluids of children and healthy qi. Pinellia ternata: pungent and warm natured herbs are not suitable for children to cough. Asarum: the toxic action is violent in property and impairs the healthy qi. Dried ginger: modern pharmacological research shows that the dried ginger can directly excite the heart and has an exciting effect on the blood vessel movement center. The heart rate of children is fast, and if the heart is excited by medicines, the heart rate is accelerated, so that myocardial ischemia and even heart failure occur. Radix Aconiti, radix Aconiti Kusnezoffii, and radix Aconiti lateralis Preparata contain aconitine components, and poisoning mainly manifests as symptoms of nervous and cardiovascular system. The realgar contains arsenic trioxide as the main component and can cause cell death, thereby causing the function and organic lesions of each system of the organism. Although poppy capsules have been reported, children are particularly sensitive to morphine, codeine has an antitussive effect in order to suppress the cough center, and sputum is not easily excreted.

In addition, common traditional Chinese medicines such as radix isatidis, radix paeoniae rubra, poria cocos and the like are easy to cause allergic symptoms of children, and the symptoms are manifested by red eruption, pruritus and swelling of broad bean size on the whole body and local skin. There are reports of allergic bronchial asthma caused by exposure to tuckahoe.

Therefore, the provision of a composition which can be used for treating recurrent respiratory tract infection in children, has a clear effect and small adverse reaction, and is a problem to be solved urgently by those skilled in the art.

Disclosure of Invention

The technical problem solved by the invention is as follows: provides a composition for treating recurrent respiratory tract infection of children, and solves the problems of uncertain effect and poor safety in the prior art.

The invention also provides a preparation method of the composition.

The invention also provides the application of the composition in preparing the medicine for treating the recurrent respiratory tract infection of children.

The technical scheme adopted by the invention is as follows:

the invention relates to a composition for treating infantile recurrent respiratory tract infection, which is prepared from the following raw materials in parts by weight: 5-50 parts of ginseng, 10-80 parts of Chinese yam, 10-60 parts of endothelium corneum gigeriae galli, 5-60 parts of dried orange peel, 5-30 parts of honey-fried licorice root, 5-40 parts of radix peucedani and 20-120 parts of bamboo juice.

Preferably, the feed additive is prepared from the following raw materials in parts by weight: 8-35 parts of ginseng, 15-65 parts of Chinese yam, 15-50 parts of endothelium corneum gigeriae galli, 8-45 parts of dried orange peel, 8-25 parts of honey-fried licorice root, 8-35 parts of radix peucedani and 25-105 parts of bamboo juice.

Preferably, the feed additive is prepared from the following raw materials in parts by weight: 10 parts of ginseng, 20 parts of Chinese yam, 20 parts of chicken's gizzard-membrane, 10 parts of dried orange peel, 10 parts of honey-fried licorice root, 10 parts of whiteflower hogfennel root and 30 parts of bamboo juice.

Preferably, the feed additive is prepared from the following raw materials in parts by weight: 30 parts of ginseng, 60 parts of Chinese yam, 40 parts of chicken's gizzard-membrane, 40 parts of dried orange peel, 20 parts of honey-fried licorice root, 30 parts of whiteflower hogfennel root and 100 parts of bamboo juice.

Preferably, the amount of the raw materials satisfies one or more of the following 3 cases:

ginseng/(tangerine peel + peucedanum root) is 0.3-0.7;

radix Glycyrrhizae Preparata/(rhizoma Dioscoreae + succus Bambusae) 0.1-0.3;

(Ginseng radix + endothelium corneum Gigeriae Galli)/succus Bambusae is 0.48-1.5.

ginseng/(tangerine peel and peucedanum root) is 0.4-0.6;

radix Glycyrrhizae Preparata/(rhizoma Dioscoreae + succus Bambusae) 0.12-0.25;

(Ginseng radix + endothelium corneum Gigeriae Galli)/succus Bambusae is 0.6-1.1.

Preferably, the composition is a preparation prepared by taking ginseng, Chinese yam, endothelium corneum gigeriae galli, dried orange peel, honey-fried licorice root, whiteflower hogfennel root and bamboo juice as raw materials and adding pharmaceutically acceptable auxiliary materials according to a conventional method.

Preferably, the formulation is an oral formulation.

The invention relates to a preparation method of a composition for treating recurrent respiratory tract infection of children, which comprises the following steps:

step 1: preparing raw materials in parts by weight;

step 2, decocting ginseng, Chinese yam, endothelium corneum gigeriae galli, dried orange peel, honey-fried licorice root and radix peucedani in water, filtering, adding bamboo juice into the filtrate, mixing uniformly, concentrating, subpackaging and sterilizing to obtain the traditional Chinese medicine.

The composition is applied to preparing medicines for treating recurrent respiratory tract infection of children. The ginseng in the invention is the dried root and rhizome of Panax ginseng C.A. Mey. Collected in autumn, washed, dried in the sun or baked. The cultivation is commonly called as 'Yuanshen'; seeding the wild mountain ginseng in the mountain forest to grow naturally is called as "mountain ginseng under forest" and is called as "seed sea". Ginseng is sweet, slightly bitter and slightly warm in taste. It enters spleen, lung, heart and kidney meridians. The functions and indications are as follows: tonify primordial qi, recover pulse to stop collapse, tonify spleen and lung, promote the production of body fluid and nourish blood, induce tranquilization and promote intelligence. Can be used for treating asthenia, collapse, cold limbs, weak pulse, spleen deficiency, anorexia, lung deficiency, cough, asthma, body fluid deficiency, thirst, internal heat, diabetes, deficiency of both qi and blood, asthenia, palpitation, insomnia, sexual impotence, and cold womb.

The yam of the invention is the dried rhizome of Dioscorea opposita Thunb of Dioscoreaceae. Sweet and mild in taste. It enters spleen, lung and kidney meridians. The functions and indications are as follows: tonify spleen and stomach, promote the production of body fluid and nourish lung, tonify kidney and astringe essence. Can be used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, cough, asthma, spermatorrhea, leukorrhagia, frequent micturition, and diabetes due to deficiency heat. The bran-parched rhizoma Dioscoreae has effects of invigorating spleen and invigorating stomach. Can be used for treating spleen deficiency, anorexia, diarrhea, loose stool, and leukorrhagia.

The endothelium corneum Gigeriae Galli is the inner wall of dry sand sac of Callus galli domestic chicken Brisson of Phasianidae. After killing the chicken, taking out the chicken gizzards, immediately encapsulating the lower inner walls, cleaning and drying. Sweet and mild in taste. It enters spleen, stomach, small intestine and bladder meridians. The functions and indications are as follows: strengthening the stomach to promote digestion, arresting seminal emission and relieving enuresis, and treating stranguria and removing calculus. Can be used for treating dyspepsia, emesis, dysentery, infantile malnutrition, enuresis, nocturnal emission, stranguria with stone, pain, gallbladder distention, and hypochondriac pain.

The dried orange peel in the invention is dry mature peel of Citrus reticulata Blanco of Rutaceae and cultivated varieties thereof. The medicinal materials are classified into pericarpium citri reticulatae and pericarpium citri reticulatae. Picking mature fruit, peeling peel, and drying in the sun or at low temperature. Bitter, pungent and warm in flavor. It enters lung and spleen meridians. The functions and indications are as follows: regulate qi to invigorate spleen, dry dampness and resolve phlegm. Can be used for treating abdominal distention, anorexia, vomiting, diarrhea, cough, and excessive phlegm.

The honey-fried licorice root in the invention is a processed product of liquorice. Sweet and mild in taste. It enters heart, lung, spleen and stomach meridians. The functions and indications are as follows: tonify spleen and stomach, replenish qi and recover pulse. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, and intermittent pulse. Wherein the Glycyrrhrizae radix is dried root and rhizome of Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat or Glycyrrhiza glabra L of Leguminosae.

The Peucedanum praeruptorum Dunn is the dried root of the Umbelliferae plant Peucedanum praeruptorum Dunn. Collected from winter to spring, when stem and leaf withered or no flower stem is taken out, the fibrous root is removed, cleaned, dried in the sun or at low temperature. Bitter, pungent and slightly cold in flavor. It enters lung meridian. The functions and indications are as follows: direct qi downward and resolve phlegm, dispel wind and clear heat. Can be used for treating phlegm-heat, asthma, slight yellow and thick phlegm, cough due to wind-heat and excessive phlegm.

The succus Bambusae is liquid obtained by heating fresh stems of Phyllostachys glauca McClure, Phyllostachys nuda McClure and Phyllostachys nuda of Gramineae and plants of the same genus. Sweet in flavor and cold in nature. Has effects of clearing heat and eliminating phlegm, and can be used for treating cough with excessive phlegm due to lung heat, asthma, chest distress, apoplexy, strong tongue, excessive phlegm and saliva, and infantile convulsion due to phlegm heat.

The pharmaceutically acceptable Excipients mentioned in the present invention include, but are not limited to, Excipients listed in "Handbook of Pharmaceutical Excipients" (american Pharmaceutical association, 10 months 1986), Handbook of Pharmaceutical Excipients (fourth edition) published by chemical industry press, or "grand universe of Pharmaceutical Excipients" (published by sichuan press group, sichuan scientific and technical press, 2006, 1 month), which are listed in the following.

Compared with the prior art, the invention has the following beneficial effects:

the traditional Chinese medicine composition is scientific in formula and reasonable in proportion, takes ginseng as a monarch drug, Chinese yam as a minister drug, radix peucedani, succus bambusae, pericarpium citri reticulatae and endothelium corneum gigeriae galli as an assistant drug and honey-fried licorice root as a conductant drug, and all the components act synergistically to jointly play a role in treating the recurrent respiratory tract infection of children, so that the traditional Chinese medicine composition is safe to take for a long time.

The ginseng in the invention is sweet, slightly bitter and slightly warm in taste, and enters spleen, lung, heart and kidney meridians; invigorating primordial qi, spleen and lung; the yam is sweet in taste and neutral in nature, and has the effects of tonifying spleen, nourishing stomach, promoting the production of body fluid and benefiting lung, and the yam enters spleen, lung and kidney channels. The Chinese yam and the ginseng are combined to play the roles of strengthening body resistance and benefiting lung, spleen and kidney together. In the invention, the peucedanum root is bitter, pungent and slightly cold in taste and enters lung meridian; direct qi downward and resolve phlegm, dispel wind and clear heat. Radix Peucedani is combined with tonifying herbs, such as Ginseng radix and rhizoma Dioscoreae, to prevent invasion of exogenous wind pathogen and influenza virus. Prepared licorice root, radix Glycyrrhizae Praeparata, is sweet and neutral in flavor, and enters heart, lung, spleen and stomach meridians; has antiallergic effect, and can be used for preventing bronchial asthma. The bamboo juice is sweet in taste and cold in nature, and can clear heat and resolve phlegm; can increase the ciliary movement of bronchus and discharge the sputum from the trachea and the bronchus. The dried orange peel is bitter, pungent and warm in taste, enters lung and spleen channels, regulates qi, strengthens spleen, eliminates dampness and reduces phlegm; the endothelium corneum gigeriae galli is sweet and neutral in flavor, and enters spleen, stomach, small intestine and bladder channels, and has the effects of invigorating stomach and promoting digestion. The tangerine peel and the chicken's gizzard-membrane are combined to play a role in removing food retention and assisting transportation, so that the infantile recurrent respiratory tract infection caused by food retention is prevented.

In the invention, the ginseng, the Chinese yam, the endothelium corneum gigeriae galli, the dried orange peel, the honey-fried licorice root and the bamboo juice have long-term eating history and good safety.

The invention adopts an oral preparation, and is convenient to produce, store, transport, carry and take.

Detailed Description

The present invention is further illustrated by the following examples, which include, but are not limited to, the following examples.

Example 1

This example discloses the raw material composition of the present invention, as shown in table 1:

TABLE 1

Example 2

This example discloses a method for preparing the composition of the present invention, which comprises:

step 1: preparing raw materials in parts by weight;

and 2, adding water into the ginseng, the Chinese yam, the endothelium corneum gigeriae galli, the dried orange peel, the honey-fried licorice root and the radix peucedani, decocting for three times, adding 8 times of water into the mixture for decocting for 2 hours each time, filtering, combining the filtrates, adding bamboo juice into the filtrate, uniformly mixing, concentrating the filtrate until the concentration solution with the density of 1.08-1.12 (60 ℃), subpackaging and sterilizing to obtain the traditional Chinese medicine.

In this embodiment, 0.3% potassium sorbate may be added to the concentrated solution, and then the concentrated solution may be packaged and sterilized.

Example 3

step 1: preparing raw materials in parts by weight;

and 2, adding 65-85% ethanol solution into the ginseng, the Chinese yam, the chicken gizzard membrane, the dried orange peel, the honey-fried licorice root and the radix peucedani, performing reflux extraction for three times, adding 6 times of ethanol solution into each time, extracting for 1.5 hours, filtering, combining filtrates, recovering ethanol, adding bamboo juice, uniformly mixing, concentrating to obtain concentrated solution with the density of 1.08-1.12 (60 ℃), packaging and sterilizing to obtain the ginseng and Chinese yam tea.

In this embodiment, 0.3% sorbitol may be added to the concentrated solution, and then the solution may be packaged and sterilized.

Example 4

step 1: preparing raw materials in parts by weight;

and 2, adding water into the ginseng, the Chinese yam, the endothelium corneum gigeriae galli, the dried orange peel, the honey-fried licorice root and the radix peucedani, decocting twice, adding 6 times of water into the filtrate for decocting for 1 hour each time, filtering, combining the filtrates, adding bamboo juice into the filtrate, uniformly mixing, concentrating the filtrate to form thick paste with the density of 1.25-1.30 (60 ℃), adding dextrin with the mass of 2 times of the thick paste, uniformly mixing, granulating by a wet method, drying and subpackaging to obtain the traditional Chinese medicine.

Example 5

An oral liquid was prepared by the method of example 2 using the formulation numbered 8 in table 1 without adding potassium sorbate. The obtained sample corresponds to 2.5g of crude drug per ml.

Example 6

An oral liquid was prepared by the method of example 3 using the formulation numbered 9 in table 1 without adding potassium sorbate. The obtained sample corresponds to 4g of crude drug per ml.

Example 7

This example discloses the clinical application of the present invention.

Case 1, xu-chi, male, 9 months old 3, and visit date of 2017, 4 months and 5 days.

The current medical history: the infant needs to catch a cold 1 time every month after the age of 1 year, and the main symptoms are fever firstly, tonsillitis is inflamed after fever subsides, and cough and severe cough are caused. The medicine needs to be taken orally and injected continuously for more than 1 week to cure.

And (4) checking: the general condition is still, the body temperature is 36.6 ℃, the pharynx is slightly red, the heart and the lung are normal, the abdomen has no pressure pain, and the rest are normal.

And (3) diagnosis: recurrent respiratory tract infections.

Treatment: the sample prepared in example 5 of the present invention was orally administered once in the morning and evening, 1ml each time before meals. A treatment course is 1 month.

The curative effect is as follows: after the infant is taken, the infant only has a cold for 1 time in three months, and respiratory tract infection does not occur. And the symptoms are very light, only the symptoms are watery nasal discharge, no fever occurs, the tonsil is not red and swollen, the cough is not caused, and the cold can be cured by taking the cold medicine orally. The cold is got twice in the last 9 months, and respiratory tract infection does not occur. The symptoms are light, no fever occurs, tonsil is not red and swollen, cough does not occur, and the oral cold medicament can be cured.

Example 8

This example discloses the clinical application of the present invention.

Case 2

Case 1, chenzhi, woman, 5 years old for 4 months, visit date 2017 for 5 months and 2 days.

The current medical history: the patient is hospitalized for bronchopneumonia for 2 years old, the patient is hospitalized for 2 times every year, the patient usually has a cold for 1 time every month, and the patient can be cured after the cold, such as cough, asthma and phlegm, and the patient needs to take the medicine continuously and inject the medicine for more than 1 week.

And (4) checking: the general condition is still clear, tonsil is not swollen, heart and lung are normal, abdomen is not tenderness, and the rest are normal.

And (3) diagnosis: recurrent respiratory tract infections.

Treatment: the sample prepared in example 6 of the present invention was orally administered once in the morning and evening, 4ml each time before meals. A treatment course is 1 month.

The curative effect is as follows: the infant patients had follow-up after starting the treatment. After the infant is taken, the infant has a cold for 2 times in three months, and respiratory tract infection does not occur. The symptoms are mild, do not reach the hospitalization standard, and are manifested by watery nasal discharge, no fever, slight red swelling of tonsil, slight cough, and recovery after oral administration of cold medicine. The patient suffered from the cold twice in the last 9 months, has no respiratory tract infection and hospitalization, and has the symptoms of running nose, no fever, no red and swollen tonsil, slight cough and recovery of the oral cold medicament.

Example 9

This example discloses the clinical application of the present invention.

Case 3

Case 1. Liu Yi, female, 3 years old 5 months, visit date 2017, 5 months and 8 days.

The current medical history: the infant starts to catch a cold after 1 more months of birth, and the main symptoms are runny nose and fever, and then tonsil inflammation and cough. The cold is 1 time per month, and the patient is hospitalized with bronchopneumonia every year, and is hospitalized 2 times per year.

And (4) checking: the general condition is still, the body temperature is 36.8 ℃, the tonsil is not swollen, the pharynx is not congested, the edema is not caused, the heart and the lung are normal, the abdomen is not pressed and painful, and the rest is normal.

And (3) diagnosis: recurrent respiratory tract infections.

The curative effect is as follows: the infant patients had follow-up after starting the treatment. After the infant is taken, the infant has a cold for 1 time in three months, and respiratory tract infection does not occur. The symptoms are light, do not reach the hospitalization standard, and are manifested by watery nasal discharge, no fever, slight red swelling of tonsil, and unobvious cough, and the symptoms can be cured by oral administration of cold medicine. The oral medicine can be used for healing. The later 9 months, the patient suffered from the cold three times, and had no respiratory tract infection. And the flat peach body is not swollen after the three cold, the cough is not obvious, hospitalization is not carried out, and the oral cold medicine is cured.

Example 10

This example provides statistical data for treatment of recurrent respiratory infections in children with the compositions of the invention.

Children with confirmed recurrent respiratory infections were randomly divided into test and negative control groups.

The test group is treated by adopting the composition of the invention, and the treatment method is that after the cold is cured, one month of taking the medicine of the invention is a treatment course. During the course of treatment, if the cold is again caused, the medicine is stopped, and the medicine is taken again after the cold is cured, wherein the total time of taking the medicine before and after the medicine is taken is one month.

The negative control group is not taken any medicine after the cold is cured.

And (3) curing: the upper respiratory tract infection is treated for 1-2 times within one year, and the lower respiratory tract infection is not caused.

The effect is shown: the upper respiratory tract infection is less than or equal to 3 times and the lower respiratory tract infection is 1 time within one year after the treatment. The symptoms are relieved earlier, the duration is short, and the cure is easy.

Improvement: the upper respiratory tract infection is less than or equal to 4 times and the lower respiratory tract infection is 1-2 times within one year after treatment.

And (4) invalidation: the clinical symptoms are unchanged before and after treatment.

TABLE 2 table of clinical trial results

	Number of experimental examples	Number of cure	Number of effect	Good number of revolutions	Number of invalid
						Test group	20	17	2	1	0
Negative control group	20	0	0	0	20

As can be seen from the above table, the invention can effectively treat the recurrent respiratory tract infection of children.

The above-mentioned embodiment is only one of the preferred embodiments of the present invention, and should not be used to limit the scope of the present invention, but all the insubstantial modifications or changes made within the spirit and scope of the main design of the present invention, which still solve the technical problems consistent with the present invention, should be included in the scope of the present invention.

Claims

1. A composition for treating recurrent respiratory tract infection of children is characterized by being prepared from the following raw materials in parts by weight: 8-35 parts of ginseng, 15-65 parts of Chinese yam, 15-50 parts of endothelium corneum gigeriae galli, 8-45 parts of dried orange peel, 8-25 parts of honey-fried licorice root, 8-35 parts of radix peucedani and 25-105 parts of bamboo juice;

the dosage of the raw materials meets more than one of the following 3 conditions:

ginseng/(tangerine peel + peucedanum root) is 0.3-0.7;

radix Glycyrrhizae Preparata/(rhizoma Dioscoreae + succus Bambusae) 0.1-0.3;

2. The composition for treating recurrent respiratory tract infection in children according to claim 1, which is prepared from the following raw materials in parts by weight: 10 parts of ginseng, 20 parts of Chinese yam, 20 parts of chicken's gizzard-membrane, 10 parts of dried orange peel, 10 parts of honey-fried licorice root, 10 parts of whiteflower hogfennel root and 30 parts of bamboo juice.

3. The composition for treating recurrent respiratory tract infection in children according to claim 1, which is prepared from the following raw materials in parts by weight: 30 parts of ginseng, 60 parts of Chinese yam, 40 parts of chicken's gizzard-membrane, 40 parts of dried orange peel, 20 parts of honey-fried licorice root, 30 parts of whiteflower hogfennel root and 100 parts of bamboo juice.

4. The composition for recurrent respiratory tract infection in children according to claim 1, wherein the amount of the raw materials satisfies one or more of the following 3 conditions:

ginseng/(tangerine peel and peucedanum root) is 0.4-0.6;

radix Glycyrrhizae Preparata/(rhizoma Dioscoreae + succus Bambusae) 0.12-0.25;

5. The composition for treating recurrent respiratory tract infection in children according to any one of claims 1 to 4, wherein the composition is a preparation prepared from ginseng, Chinese yam, endothelium corneum gigeriae galli, dried orange peel, honey-fried licorice root, whiteflower hogfennel root and bamboo juice as raw materials, and pharmaceutically acceptable auxiliary materials by a conventional method.

6. The composition for treating recurrent respiratory tract infections in children according to claim 5, wherein the preparation is an oral preparation.

7. The method of preparing a composition for the treatment of recurrent respiratory tract infections in children according to any one of claims 1 to 6, comprising the steps of:

step 1: preparing raw materials in parts by weight;

8. Use of a composition according to any one of claims 1 to 6 for the manufacture of a medicament for recurrent respiratory infections in children.