CN102106999A - Chinese medicinal compound preparation for treating dysphagia due to stroke and preparation method thereof - Google Patents
Chinese medicinal compound preparation for treating dysphagia due to stroke and preparation method thereof Download PDFInfo
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- CN102106999A CN102106999A CN201110035741XA CN201110035741A CN102106999A CN 102106999 A CN102106999 A CN 102106999A CN 201110035741X A CN201110035741X A CN 201110035741XA CN 201110035741 A CN201110035741 A CN 201110035741A CN 102106999 A CN102106999 A CN 102106999A
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- rhizoma zingiberis
- zingiberis recens
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Abstract
The invention relates to a Chinese medicinal compound preparation for treating dysphagia due to stroke and a preparation method thereof. The Chinese medicinal compound preparation is prepared from ginger, clematis root and cassia bark which serve as raw materials, wherein the preparation method comprises the following steps of: squeezing ginger to obtain juice, adding cassia bark and clematis root into ginger dregs, and performing steam distillation on the mixture to obtain essential oil; boiling and concentrating dregs of decoction, and depositing the dregs of decoction in alcohol, adding ginger juice into supernate, filtering, and mixing the mixture and the essential oil to prepare medicinal formulations. The extract of the Chinese medicinal compound preparation has the obvious effect of relieving the dysphagia due to the stroke, is convenient to take, and has high controllability and stability and high safety.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, relate in particular to a kind of compound Chinese medicinal preparation for the treatment of dysphagia behind the apoplexy and preparation method thereof.
Background technology
Apoplexy is an apoplexy, is to cause one of modal reason of dysphagia.The dysphagia incidence rate is about 45% after the apoplexy, and the middle severe dysphagia incidence rate of wrong suction is then up to 33%.Dysphagia can cause the nutrition Deficiency of Intake, is prone to aspiration pneumonitis, even suffocates.Therefore, in time adopt an effective measure, the active treatment dysphagia is to promoting the rehabilitation of apoplexy, and it is significant to improve prognosis.Dysphagia has the method for certain curative effect to comprise oral medicinal herb, acupuncture, function of deglutition rehabilitation training etc. behind the clinical treatment apoplexy at present, but all has certain limitation, is difficult to be used widely clinically, has influenced the performance of curative effect.Western medicine and Chinese patent medicine still belong to blank relatively easily.Seeking the simple and effective Therapeutic Method at dysphagia behind the apoplexy, is present clinical urgent needs.
Summary of the invention
The objective of the invention is to overcome the limitation of dysphagia method behind the clinical treatment apoplexy commonly used at present, for dysphagia patients behind the apoplexy provides a kind of Chinese patent medicine preparation safe and effective, quality controllable, easy to use and preparation method thereof.
It is considered herein that it is the main pathogenesis of dysphagia behind the apoplexy that phlegm stagnation in collateral is stopped up key, tongue is the Seedling of the heart, and the heart is the big masters of the vital organs of the human body, and throat is that many passages through which vital energy circulates are concentrated and followed capable part.At the pathogenesis that causes dysphagia, using drugs to form a prescription, sore-throat relieving is sensible, and with modern crafts Chinese medicine is made external preparation, selects oropharynx local application, except that local action, but dredging the meridian still, regulating functions of ZANG FU-organs, thus improve dysphagia.
The present invention is achieved by the following technical solutions:
The present invention treats the compound Chinese medicinal preparation of dysphagia behind the apoplexy, and it is made up of following materials based on weight,
1～10 part of 1～10 portion of Cortex Cinnamomi of 1～25 part of Radix Clematidis of Rhizoma Zingiberis Recens
Wherein: Rhizoma Zingiberis Recens is squeezed the juice, standby; The Rhizoma Zingiberis Recens slag adds Cortex Cinnamomi, the Radix Clematidis vapor distillation gets volatile oil, and is standby; The medicinal residues decocting in water, concentrate, precipitate with ethanol, get supernatant and add after Rhizoma Zingiberis Recens juice filters, mix with volatile oil again, make pharmaceutically useful dosage form.
In the preferred embodiment of the invention, form and be mixed with various preparations by following medical material:
1 part of 1 portion of Cortex Cinnamomi of 3 parts of Radix Clematidis of Rhizoma Zingiberis Recens
Wherein: (1) Rhizoma Zingiberis Recens is squeezed the juice, and is standby;
(2) the Rhizoma Zingiberis Recens slag adds Cortex Cinnamomi, the Radix Clematidis vapor distillation gets volatile oil, and is standby;
(3) medicinal residues behind the extraction volatile oil decoct with water 2 times, each 6 times of water gagings, and decocting time is 2 hours;
(4) extract the mother solution dosing pulp water decocting liquid of volatile oil after, be concentrated into density 1.08, transfer to 95 ethanol and contain alcohol amount 70%, cold preservation is spent the night, and filters, precipitation discards;
(5) precipitate with ethanol supernatant reclaims ethanol, does near, adds Rhizoma Zingiberis Recens juice, adds Tween 80, and potassium sorbate adds deionized water;
(6) after the use filter cloth filters, add volatile oil again, be loaded in the vial, bottle cap sealing, 100 ℃ of sterilizations in 30 minutes can be used;
(7) as said extracted liquid is concentrated, drying is pulverized, and mixes with volatile oil and pharmaceutic adjuvant again, can be made into pharmaceutically receptible various dosage forms.
The dosage form of wherein said preparation is: granule, capsule, tablet, oral liquid, pill, suspensoid, lyophilized powder, drop pill, pellet, buccal tablet, oral cavity disintegration tablet, soft gelatin capsule, soft capsule, dispersible tablet, solution, aerosol, spray, cataplasma or patch.Spray most preferably.
Rhizoma Zingiberis Recens is the fresh rhizome of zingiber in the present invention's prescription.Contain volatile oil, be mainly zingiberol, zingiberene, phellandrene, citral, linalool etc.; Contain the pungency component gingerol again, decompose generation zingiberone, ginger ketenes etc.Gingerol has stimulation to oral cavity stomach function regulating mucosa, can secrete appetite stimulator by facilitating digestion liquid.Intestinal tension force, the rhythm and pace of moving things and wriggling are increased.Have the tip town to tell effect, effective ingredient is the mixture of zingiberone and ginger ketenes.Breathing and vasomotor center there are excitation, can blood circulation promoting.
Radix Clematidis is the dry root and rhizome of cohosh Radix Clematidis in the prescription.Mainly contain Anemonin, anemonol, sterol, saccharide, Saponin, lactone, phenols, aminoacid.Smooth muscle there is certain excitation.
Cortex Cinnamomi is cinnamomic dried bark of canella and branch skin.Cortex cinnamomi japonici (Ramulus Cinnamomi) contains volatile oil 1.98%-2.06%, and its main component is a cinnamic aldehyde, accounts for 52.92%-61.20%, also has acetic acid Cortex cinnamomi japonici (Ramulus Cinnamomi) ester, ethyl cinnamate etc.Oleum Cinnamomi stimulates olfactory sensation, can promote the stomach function reflectingly, also can directly to gastric mucosa demulcent stimulation be arranged, and secretion is increased, and wriggling strengthens.Natrium cinnamicum has the effect of expansion rabbit blood vessel, can promote blood circulation.Oleum Cinnamomi has powerful bactericidal action, and is better than negative patient to the effect of Gram-positive bacterium.
We's three flavor medicines, Rhizoma Zingiberis Recens is a monarch drug, the hot temperature of loosing is logical, the waking up the patient from unconsciousness by dissipating phlegm sore-throat relieving; Cortex Cinnamomi is hot, and the warming YANG promoting the circulation of blood helps Rhizoma Zingiberis Recens sensible.The Radix Clematidis twelve channels and collaterals that passes through is the medicine commonly used that ancients treat fishbone stalk larynx.
The beneficial effect of medicine of the present invention shows: show that by clinical observation medicine of the present invention has the effect of alleviating dysphagia behind the apoplexy, and use conveniently that low price has no adverse reaction.Concrete observed content is as follows:
1. material and method
1.1 clinical data
Collect 65 routine apoplexy (apoplexy) reconvalescents altogether, be divided into treatment group and matched group at random, wherein 35 examples are organized in treatment, matched group 30 examples, all turn out to be the patient of apoplexy through CT or MRI, and have the dysphagia primary symptom, hollow Tian Shi water drinking test is estimated more than 3 grades, and the course of disease is between 2 thoughtful half a year.Treatment is organized in 35 examples, and both sides are blocked 8 examples simultaneously, and 15 examples are successively blocked in both sides, multiple lacuna cerebral infarction 9 examples, cerebral hemorrhage 3 examples.In matched group 30 examples, both sides are blocked 5 examples simultaneously, and 13 examples are successively blocked in both sides, multiple lacuna cerebral infarction 11 examples, cerebral hemorrhage 1 example.Two groups are not all being had significant difference (every equal P＞0.05) aspect sex, age, the course of disease, dysphagia degree, complication and history of past illness scoring and the Dementia scale scoring of Chang Gu river.
1.2 Therapeutic Method
All use routine medication for two groups: 20 milliliters of Herba Erigerontis injection, piracetam injection 8 grams, intravenous drip, every day 1 time.Treatment group on this basis adds with logical pharynx aerosol, and logical pharynx aerosol is by the Drug Manufacturing Room of the court preparation, 10 milliliters every.Usage: medication 30 minutes before the meal every day three, shower nozzle is aimed in the middle of the pars oralis pharyngis and both sides are respectively sprayed and got final product (being that each medication is sprayed 3 times altogether) for 1 time at every turn.Medication was added up curative effect after 28 days.
1.3 dysphagia evaluation methodology and criterion of therapeutical effect
Be responsible for record, evaluation doing well,improving situation every day and the grading of hollow Tian Shi water drinking test by the special messenger.Hollow Tian Shi water drinking test can simple and easy judgement dysphagia degree, and method is to allow the patient sit up straight, and drinks 30ml eliminating cold for resuscitation water, and observation post takes time and chokes and cough situation.
Evaluation methodology: 1 grade: can successfully once swallow; 2 grades: at twice, can swallow with not choking; 3 grades; Can once swallow, cough but have to choke; 4 grades: swallow at twice that also having chokes coughs; 5 grades: choke repeatedly and cough, the full dose acataposis.
Criterion of therapeutical effect: cure: dysphagia disappears, 1 grade of water drinking test evaluation; Effectively: dysphagia is obviously improved, 2 grades of water drinking test evaluations; Invalid: dysphagia is improved not remarkable, and water drinking test is evaluated more than 3 grades.
2. therapeutic outcome
The dysphagia curative effect relatively before and after the table 1 liang group treatment
35 examples are organized in treatment, cure 15 examples (42.9%), effective 17 examples (48.6%), invalid 3 examples (8.6%), total effective rate 91.4%; Matched group 30 examples are cured 4 examples (13.3%), effective 16 examples (53.3%), invalid 10 examples (33.3%), total effective rate 66.7%.Two groups of curative effects relatively have significant difference (P＜0.01).
3. untoward reaction: do not see obvious adverse reaction.
The specific embodiment
The present invention will be further described below in conjunction with specific embodiment, and following embodiment only is used to the present invention is described and is not limitation of the present invention.Crude drug source wherein: all raw materials are commercially available, and meet standards of pharmacopoeia.
Rhizoma Zingiberis Recens: this medical material is the fresh rhizome of zingiber Zingiber officinale Rose..
Radix Clematidis: be the dry root and rhizome of cohosh Radix Clematidis Clematis chinensis Osbeck..
Cortex Cinnamomi: be dried bark and the branch skin of canella Cortex Cinnamomi Cinnamomum cassia Presl..
Press following proportioning weighting raw materials:
1 part of 1 portion of Cortex Cinnamomi of 3 parts of Radix Clematidis of Rhizoma Zingiberis Recens
(1) above three flavor raw materials are got Rhizoma Zingiberis Recens and squeezed the juice, and are standby;
(2) the Rhizoma Zingiberis Recens slag adds Cortex Cinnamomi, the Radix Clematidis vapor distillation gets volatile oil, and is standby;
(3) medicinal residues behind the extraction volatile oil decoct with water 2 times, each 6 times of water gagings, and decocting time is 2 hours;
(4) extract the mother solution dosing pulp water decocting liquid of volatile oil after, be concentrated into density 1.08, transfer to 95 ethanol and contain alcohol amount 70%, cold preservation is spent the night, and filters, precipitation discards;
(5) precipitate with ethanol supernatant reclaims ethanol, does near, adds Rhizoma Zingiberis Recens juice, adds Tween 80, and potassium sorbate adds deionized water;
(6) after the use filter cloth filters, add volatile oil again, be loaded in the vial, bottle cap sealing, 100 ℃ of sterilizations in 30 minutes promptly get medicament spraying agent of the present invention.
Claims (5)
1. compound Chinese medicinal preparation for the treatment of dysphagia behind the apoplexy, it is to be prepared through following steps by following materials based on weight:
1～10 part of 1～10 portion of Cortex Cinnamomi of 1～25 part of Radix Clematidis of Rhizoma Zingiberis Recens
Wherein: Rhizoma Zingiberis Recens is squeezed the juice, standby; The Rhizoma Zingiberis Recens slag adds Cortex Cinnamomi, the Radix Clematidis vapor distillation gets volatile oil, and is standby; The medicinal residues decocting in water, concentrate, precipitate with ethanol, get supernatant and add after Rhizoma Zingiberis Recens juice filters, mix with volatile oil again, make pharmaceutically useful dosage form.
2. the described compound preparation of claim 1 is characterized in that the weight proportion of described crude drug is:
1 part of 1 portion of Cortex Cinnamomi of 3 parts of Radix Clematidis of Rhizoma Zingiberis Recens
Wherein: (1) Rhizoma Zingiberis Recens is squeezed the juice, and is standby;
(2) the Rhizoma Zingiberis Recens slag adds Cortex Cinnamomi, the Radix Clematidis vapor distillation gets volatile oil, and is standby;
(3) medicinal residues behind the extraction volatile oil decoct with water 2 times, each 6 times of water gagings, and decocting time is 2 hours;
(4) extract the mother solution dosing pulp water decocting liquid of volatile oil after, be concentrated into density 1.08, transfer to 95 ethanol and contain alcohol amount 70%, cold preservation is spent the night, and filters, precipitation discards;
(5) precipitate with ethanol supernatant reclaims ethanol, does near, adds Rhizoma Zingiberis Recens juice, adds Tween 80, and potassium sorbate adds deionized water;
(6) after the use filter cloth filters, add volatile oil again, be loaded in the vial, bottle cap sealing, 100 ℃ of sterilizations in 30 minutes can be used;
(7) as said extracted liquid is concentrated, drying is pulverized, and mixes with volatile oil and pharmaceutic adjuvant again, can be made into pharmaceutically receptible various dosage forms.
3. compound preparation according to claim 1 and 2, the dosage form of wherein said preparation is: granule, capsule, tablet, oral liquid, pill, suspensoid, lyophilized powder, drop pill, pellet, buccal tablet, oral cavity disintegration tablet, soft gelatin capsule, soft capsule, dispersible tablet, solution, aerosol, spray, cataplasma or patch.
4. according to the compound preparation described in the claim 3, wherein said dosage form is spray, aerosol, cataplasma or patch, buccal tablet, oral cavity disintegration tablet.
5. the described apoplexy of claim 1 promptly refers to apoplexy, comprises hemorrhagic apoplexy and cerebral infarction.
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Cited By (3)
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| CN102389533A (en) * | 2011-11-11 | 2012-03-28 | 王贤军 | Medicinal composition for treating cerebral apoplexy and preparation method thereof |
| US9867790B2 (en) * | 2013-07-22 | 2018-01-16 | Nestec S.A. | Compositions and methods using cuminaldehyde |
| CN109260420A (en) * | 2018-11-19 | 2019-01-25 | 天津赛尔康生物医药科技有限公司 | A kind of Chinese medicine preparation and preparation method thereof for treating bulbar paralysis |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389533A (en) * | 2011-11-11 | 2012-03-28 | 王贤军 | Medicinal composition for treating cerebral apoplexy and preparation method thereof |
| US9867790B2 (en) * | 2013-07-22 | 2018-01-16 | Nestec S.A. | Compositions and methods using cuminaldehyde |
| CN109260420A (en) * | 2018-11-19 | 2019-01-25 | 天津赛尔康生物医药科技有限公司 | A kind of Chinese medicine preparation and preparation method thereof for treating bulbar paralysis |
| CN109260420B (en) * | 2018-11-19 | 2021-12-14 | 天津赛尔康生物医药科技有限公司 | Traditional Chinese medicine composition for treating bulbar paralysis and preparation method thereof |
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| CN102106999B (en) | 2016-05-11 |
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