CN105168496B - A kind of Chinese traditional medicine composition and preparation method preventing and treating Duck Hepatitis Virus - Google Patents
A kind of Chinese traditional medicine composition and preparation method preventing and treating Duck Hepatitis Virus Download PDFInfo
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Abstract
A kind of Chinese medicine composition preventing and treating Duck Hepatitis Virus, belong to veterinary drug preparation field, it be composed of by weight following Chinese medicinal ingredients: 5~6 parts of Herba Euphorbiae Humifusae, 5~6 parts of Asian puccoon, 1~3 part of Cortex Phellodendri, 1~3 part of oriental wormwood, 1~3 part of radix bupleuri, 1~3 part of peppermint, 1~3 part of hawthorn, 1~3 part of honeysuckle, 1~3 part of Radix Glycyrrhizae and poplar bark lipoid form.The present invention is made of pure Chinese herbal medicine, from a wealth of sources, at low cost, and cure rate is high, and drug noresidue has no toxic side effect, and especially with decocting extraction is crossed, is maintained traditional Chinese medicine technique, is more easily absorbed.Have the function of significant clearing heat and detoxicating, hemostasis and dysentery-stopping, temperature compensation stomach and intestine and adjust body function, effectively treats out duck virus hepatitis, shorten convalescence.It is easy to use.Clinical test proves that cure rate reaches 85% or more, there is unique curative effect.
Description
Technical field
The invention belongs to veterinary drug preparation fields, more particularly to a kind of Chinese medicine group for preventing and treating Duck Hepatitis Virus
Conjunction and preparation method.
Background technique
It is popular in duck hepatitis A virus (the Duck Hepatitis A Virus of winter-spring season more;), it DHAV is a kind of duck
The propagated virus of acute contact, DHAV mainly result in duckling ataxia, turn-take, kick after bipod spasm, and head is to minds such as back
Through symptom, disease morbidity is anxious, propagates fastly, duckling often dies within several hours after the onset.
Currently, preventing the disease, the most commonly used is vaccines and antibody.Vaccine is to pass through virus by the internal organs of acquisition morbidity duck
Separation identification, screens suitable strain and is subject to adjuvant and be prepared, and when use aims at prevention.Since the development of vaccine is often stagnant
Afterwards in the infection of virus, in face of new variant viral, vaccine is usually without preventive effect;Antibody is strong to animal by vaccine
Change immune, then acquire the serum or produced ovum of animal, be prepared by different production technology extractions, when use with
Promptly put prevention first.Since the development of antibody has hysteresis quality as vaccine, prevention and control to duck hepatitis also have
Limitation.
Clinically also usually duck hepatitis is prevented and treated using Chinese medicine and antiviral Western medicine, such as Cortex Phellodendri, polygonum cuspidate, fish
Raw meat grass etc., which has duck hepatitis virus etc., to be significantly inhibited effect and has obtained clinical verification.But actually many situations
Under, traditional Chinese medicine is since its prescription is unreasonable, and due effect cannot be played by frequently resulting in Chinese medicine, and clinical application effect is not good enough;
Antiviral Western medicine such as Ribavirin, amantadine etc. is forbidden making by the Ministry of Agriculture at present due to there is drug resistance
With.Therefore, using traditional Chinese medicine, researching and developing a kind of specific medicament combination for treating duck virus hepatitis has highly important clinic
Meaning.
There are two aspects for the antiviral dominant mechanism of Chinese medicine: first is that directly inhibiting virus, main blocking virus reproductive process
In some link, achieve the purpose that viral infection resisting, such as folium isatidis, radix scutellariae, honeysuckle, Radix Isatidis to respiratory diseases
Poison;Fructus Forsythiae, the coptis, Cortex Phellodendri are to enterovirus;Cortex Phellodendri, polygonum cuspidate, cordate houttuynia have significant suppression to duck hepatitis virus etc.
Production is used.Second is that inhibiting virus indirectly, inducing other cell factors such as body generation interferon by Chinese medicine or improving immune
System and achieve the purpose that inhibit virus, such as honeysuckle, viola mandshurica, wild chrysanthemum to chicken pass branch virus have preferably inhibit effect
Fruit;Dandelion, cordate houttuynia, mountain lotus, wild chrysanthemum can continue cytopathy caused by virus.Liang Rong, permitted to believe the plate indigo plant such as rigid
Root, Radix Codonopsis, Poria cocos etc. be clearing heat and detoxicating, the drug therapy based on enriching yin invigorating the spleen manually attacks infections bursal disease chicken 34 of poison,
Effective percentage is 93%, and the self-healing rate of blank control group is only 50% (1998.12 " Chinese animal doctor's science and technology ").Chen Dekun, Li Jun
The researchs such as raw think that it is vaccine immune chicken that the compound Chinese medicine extracts such as Radix Codonopsis, Radix Astragali, Herba Epimedii, which cooperate with ND II, and it is anti-that ND can be improved
Body potency extends its time retained in vivo, and improves the protective rate (1998.11 " Chinese animal doctor's science and technology ") of group.Jiang Wencan,
Wang Tianyi etc. with pure Chinese herbal medicine preparation " gram pest spirit " to newcastle disease natural cases carried out comparison therapeutic test, expanding test,
Test is promoted and applied, controlled newcastle disease diseased chicken 51250, cure rate is up to 92.4% (1997.5 " Chinese veterinarian's medical magazine ").?
The application stone reed removing toxic substances such as Ke Jia, Guo's generation is peaceful, which are dissipated, passes branch with various dose and route of administration prevention and treatment artificial infection chicken's kidney, shows stone reed
Removing toxic substances dissipates good (" Chinese veterinarian's medical magazine " 1998.6) to branch control efficiency is passed.
Therefore, an effective Chinese traditional medicine composition is constructed to have great importance for clinical application.
Summary of the invention
The present invention provides it is a kind of prevent and treat Duck Hepatitis Virus Chinese traditional medicine composition and preparation method, the present invention according to
According to Chinese veterinarian's theory to Duck Hepatitis Virus diagnosis and treatment based on an overall analysis of the illness and the patient's condition, prescription compatibility is screened, prevention to Duck Hepatitis Virus and is controlled
Treating has remarkable result, and has no toxic side effect.
The present invention is achieved by the following technical solutions:
A kind of Chinese medicine composition preventing and treating duck virus hepatitis, it is combined by weight by following Chinese medicinal ingredients
It forms: 5~6 parts of Herba Euphorbiae Humifusae, 5~6 parts of Asian puccoon, 1~3 part of Cortex Phellodendri, 1~3 part of oriental wormwood, 1~3 part of radix bupleuri, 1~3 part of peppermint, hawthorn
1~3 part, 1~3 part of honeysuckle, 1~3 part of Radix Glycyrrhizae and poplar bark lipoid composition, the poplar bark lipoid in admixing medical solutions
Final concentration 0.1-0.5% (weight ratio), the admixing medical solutions are remaining composition in addition to poplar bark lipoid in 4 times of medicine groups
Solution after decocting in the water (weight ratio) of conjunction is made after then adding poplar bark lipoid.
A kind of preparation method for the Chinese medicine composition preventing and treating duck virus hepatitis, by 5~6 portions of humid euphorbias
Grass, 5~6 portions of Asian puccoons, 1~3 portion of Cortex Phellodendri, 1~3 portion of oriental wormwood, 1~3 part of radix bupleuri, 1~3 portion of peppermint, 1~3 portion of hawthorn, 1~3 part pair
Flower, 1~3 portion of Radix Glycyrrhizae, add the water (weight ratio) of 4 times of pharmaceutical compositions, and boiled water is decocted half an hour, cooling, filter to get filtrate, and poplar is added
Bark lipoid, poplar bark lipoid final concentration content control in 0.1-0.5% (weight ratio), stir, obtain traditional Chinese medicine extraction
Liquid composition.
The application method of the composition of medicine, duckling start free water since birth, and it is of the invention that per kilogram water adds 10ml
Drug is used in conjunction 3 days, 3~5 days as one therapeutic course, can effectively prevent duckling and duck virus hepatitis occurs.
Herbal control duck virus hepatitis has shown that good momentum, and Chinese herbal medicine can not only prevent and treat duck viral liver
Scorching disease, can also solve medicament residue problem, have good development prospect.There is good heat-clearing solution as Herba Euphorbiae Humifusae is proved to be a kind of
Poison, removing dampness through diuresis and removing jaundice;The effect of promoting blood circulation and hemostasis, has very high medical value, and distributed more widely, and there are growth in China various regions,
Materials are convenient, cheap.
Herba Euphorbiae Humifusae: alias rhizoma polygoni paleacei, acalyphae,herba grass, acalyphae,herba, small worm crouch, and list, bermudagrass herb, general valve are careless, blood wind is careless, horse
Ant grass etc., acrid flavour are put down, nontoxic, channel tropism: lung, liver, stomach, large intestine, bladder meridian.With clearing heat and detoxicating;Removing dampness through diuresis and removing jaundice;Promoting blood circulation stops
Blood.Cure mainly dysentery, diarrhea, jaundice, hemoptysis, haematemesis, hematuria, hematochezia, metrorrhagia and metrostaxis, agalactia, treating swelling and pain by traumatic injury and pathopyretic ulcer.
Asian puccoon: Asian puccoon be also known as Zi Dan, purple Yao, blood etc., Asian puccoon be comfrey Asian puccoon, Xinjiang-Tibet vacation Asian puccoon or Onosma paniculatum
Root.Taste bitter and cold enters percardium, Liver Channel.Cure mainly cool blood, promoting blood circulation, removing toxic substances promoting eruption.For blood-heat and toxin exuberance, atropurpureus macula, morbilli
Impermeable, sore, eczema, scald.Clearing heat and cooling blood, be used for morbilli, pyreticosis ecchymosis, eczema, hematuria, blood strangury, bloody flux, sore,
Erysipelas, burn, constipation with heat retention.
Cortex Phellodendri also known as CORTEX PHELLODENDRI AMURENE, CORTEX PHELLODENDRI CHINENSE;Anaesthetic name: Xia Mao is rutaceae wampee Phellodendron
The dry bark of chinense Schneid. or cork tree Phello-dendron amurense Rupr.Bitter cold in nature, main kidney,
Bladder meridian has effects that heat-clearing and damp-drying drug, purging fire for removing toxin, clearing away deficiency-heat, cures mainly enterogastric diseases.Studies have shown that Cortex Phellodendri has
Resisting pathogenic microbes effect: recording according to [PhytotherRes], and the alcohol extracting thing paraxylene of Cortex Phellodendri and the coptis induces small
Mouse auricle inflammation has apparent inhibiting effect (P < 0.05);Compound phellodendron bark vena axillaris is injected 200mg (kg), and generation with intravenous is filled in
The rice same bacteriostasis of pine 100mlPmg.Cortex Phellodendri is inhibited to gastric ulcer: having it is demonstrated experimentally that removing the Huang of alkaloid
Cypress water soluble ingredient can inhibit stress stress the active reduction of SOD in Mice, PFE2 amount before water logging can be made to dramatically increase, and have
The trend of PGE2 amount reduction after inhibition water logging.Illustrate that it has inhibiting effect to gastric ulcer.
Poplar bark lipoid (Poplar Bark Lipid, PBL) is the orange-yellow fat-soluble object of one kind extracted from poplar bark
Matter is a kind of natural complex mixture, rich in substances such as a large amount of polysaccharide, organic acid, sterol, phosphatide, glucoside and vitamins.
Polysaccharide, which has, promotees thymic humoral reaction, stimulation reticuloendothelial system, improves body specific immune response ability;Organic acid tool
Play the role of enhancing body's immunity, can stimulate and promote Function of mononuclear phagocyte, fights immunosupress to immune device
The inhibiting effect of official;Glucoside can speed up the generation of antibody, promote lymphocyte transformation and enhancing reticuloendothelial system function etc.
Effect.The coordinating and unifying in animal body of these substances, greatly improves the immunity function of animal body.By being immunoreacted sections observation
The poultry Main Immune Organs such as bursa of farbricius, thymus gland, spleen, caecum and tonsillotome etc. for injecting poplar bark lipoid produce strongly
Immune response.Hence, it can be determined that poplar bark lipoid has stronger immunological enhancement.The research of these mechanism,
Antibody is assisted to provide theories integration for preventing and treating certain poultry diseases for poplar bark lipoid.
For the immune effect of poplar bark lipoid, we are proved early-stage study, and poplar bark lipoid is as raising immunity of organism
The immunopotentiator of power, also by the stringent influence of dosage, immune induction effect has amphicheirality.Suitable dosage has just
To immunological enhancement, the additive capacity of poplar bark lipoid affects the responsing reaction degree of Immune Organs of Body.
The compatibility of Chinese medicine composition needs to carry out diagnosis and treatment based on an overall analysis of the illness and the patient's condition to disease according to Chinese veterinarian's theory, screens prescription, rationally matches
5, can be only achieved prevention of disease and treatment has remarkable result.Therefore, the pharmacological action that the different drug of compatibility is embodied
Also different.The drugs such as above-mentioned Herba Euphorbiae Humifusae, Asian puccoon, Cortex Phellodendri, oriental wormwood, radix bupleuri, peppermint, hawthorn, honeysuckle, Radix Glycyrrhizae phase 5, full side is played altogether
The effect of clearing heat and detoxicating, strengthening spleen and nourishing stomach, strengthening vital QI to eliminate pathogenic factors, hemostasis and dysentery-stopping, then it is equipped with poplar bark lipoid, there is surprise to duck virus hepatitis
Effect.
The present invention compared with prior art the utility model has the advantages that the present invention with the hemostasis of clearing heat and detoxicating, stop dysentery, improve immunity of organism
Power is the rules for the treatment of, and reasonable recipe, preparation process is simple, applied widely.The present invention is made of pure Chinese herbal medicine, from a wealth of sources,
At low cost, cure rate is high, and drug noresidue has no toxic side effect, and especially extracts with crossing decocting, maintain traditional Chinese medicine technique,
It more easily absorbs.Have the function of significant clearing heat and detoxicating, hemostasis and dysentery-stopping, temperature compensation stomach and intestine and adjust body function, effectively treats
Duck virus hepatitis shortens convalescence.It is easy to use.Clinical test proves that cure rate reaches 85% or more, there is unique curative effect.
Specific embodiment
In conjunction with the preferred embodiment, to the specific embodiment provided according to the present invention, details are as follows:
Embodiment 1
By weight 5000g:5000g:1000g:1000g:1000g:1000g:1000g:1000g:1000g, weigh ground
The above nine tastes Chinese herbal medicine is added 68 kg of water to decoct 2 by bright and beautiful grass, Asian puccoon, Cortex Phellodendri, oriental wormwood, radix bupleuri, peppermint, hawthorn, honeysuckle, Radix Glycyrrhizae
It is secondary, 0.5 hour every time, collecting decoction, filtration cooling, be added poplar bark lipoid, make its final concentration of 0.1%, stir evenly.With
When preventing and treating out duck virus hepatitis, 10ml is added according to per kilogram water in drinking-water, free water is used in conjunction 3 days.
Embodiment 2
By weight 5000g:6000g:1500g:1000g:1000g:1000g:1000g:1000g:1000g, weigh ground
The above nine tastes Chinese herbal medicine is added 74 kg of water to decoct 2 by bright and beautiful grass, Asian puccoon, Cortex Phellodendri, oriental wormwood, radix bupleuri, peppermint, hawthorn, honeysuckle, Radix Glycyrrhizae
It is secondary, 0.5 hour every time, collecting decoction, filtration cooling, be added poplar bark lipoid, make its final concentration of 0.2%, stir evenly.With
When preventing and treating out duck virus hepatitis, 5ml is added according to per kilogram water in drinking-water, free water is used in conjunction 4 days.
Embodiment 3
By weight 6000g:6000g:1000g:1500g:1500g:1500g:1500g:1500g:1500g, weigh ground
The above nine tastes Chinese herbal medicine is added 88 kg of water to decoct 2 by bright and beautiful grass, Asian puccoon, Cortex Phellodendri, oriental wormwood, radix bupleuri, peppermint, hawthorn, honeysuckle, Radix Glycyrrhizae
It is secondary, 0.5 hour every time, collecting decoction, filtration cooling, be added poplar bark lipoid, make its final concentration of 0.3%, stir evenly.With
When preventing and treating out duck virus hepatitis, 15ml is added according to per kilogram water in drinking-water, free water is used in conjunction 5 days.
Embodiment 4
By weight 6000g:5000g:1000g:1500g:1500g:1500g:1500g:1500g:1500g, weigh ground
The above nine tastes Chinese herbal medicine is added 81 kg of water to decoct 2 by bright and beautiful grass, Asian puccoon, Cortex Phellodendri, oriental wormwood, radix bupleuri, peppermint, hawthorn, honeysuckle, Radix Glycyrrhizae
It is secondary, 0.5 hour every time, collecting decoction, filtration cooling, be added poplar bark lipoid, make its final concentration of 0.4%, stir evenly.With
When preventing and treating out duck virus hepatitis, 20ml is added according to per kilogram water in drinking-water, free water is used in conjunction 5 days.
Clinical test:
Example 1:
Certain duck of Fushan, cherry valley duck
This raises cherry valley duck 10000,5 days about dead 1500 (death rates 15%) after shell out, and in addition 2000
Loss of appetite.Clinical and laboratory diagnosis is duck virus hepatitis, 1000 duckling oral antibiotic such as Enrofloxacins etc.,
Rehabilitation 300, dead 150, Shang You 550 morbidities.Due to can not thoroughly cure, this last part duckling is eliminated.Remaining
1000 morbidity ducks take orally the pharmaceutical composition of embodiment 1, and the duckling that falls ill after 4 days is down to 150, dead 50, remaining 800
Rehabilitation is simultaneously raised to 40 days, is all delivered for sale.
The pharmaceutical composition that embodiment 1 is all taken orally to the duckling not fallen ill does not show duck virus hepatitis, and raising is extremely
It 40 days, all delivers for sale.
Example 2:
Certain duck of Yantai Laiyang, sheldrake
This raises duckling 15000, out after shell 6 days 1000 there is loss of appetite, nervous symptoms, dead 420.Face
Bed and laboratory diagnosis are duck virus hepatitis, 500 morbidity duckling oral antibiotic Enrofloxacins etc., rehabilitation 90, extremely
150 are died, Shang You 260 morbidities.Another 500 morbidities duckling takes orally the pharmaceutical composition of embodiment 2, and fall ill duckling after 3 days
20 are down to, dead 6, remaining 574 rehabilitation, last whole health were delivered for sale to 42 days for feeding.A batch is raised again afterwards to shell out
Afterwards 6 days when, there are same clinical symptoms, be judged as duck virus hepatitis infection after, the medicine of inventive embodiments 2 is administered orally in full group
Compositions and application method, the state of an illness is controlled after 3 days, and duckling only dead 10, effect is obvious.
Example 3:
Yantai meat duck field, local varieties
This raises duckling 4000, out 7 days 1800 appearance drawing watery stools after shell, loss of appetite, and dead 620.
Clinical and laboratory diagnosis is duck virus hepatitis infection, 600 morbidity duckling oral antibiotic Enrofloxacins etc., rehabilitation
120, dead 180, Shang You 300 morbidities.Another 600 morbidities duckling takes orally the pharmaceutical composition of embodiment 3, after 3 days
Morbidity duckling is down to 24, and dead 10, remaining 566 rehabilitation, to 45 days, last whole health were delivered for sale for feeding.It is 600 remaining
The drug of oral embodiment 4, morbidity duckling is down to 16 after 3 days, and dead 6, remaining 578 rehabilitation is fed to 45 days most
Whole health are delivered for sale afterwards.When raising a batch to 7 days after shell out again afterwards, there are same clinical symptoms, be judged as duck virus hepatitis
After infection, the pharmaceutical composition and application method of inventive embodiments 3 is administered orally in half, the other half uses inventive embodiments 3
Pharmaceutical composition and application method, the state of an illness is controlled after 3 days, and duckling only dead 10, effect is obvious.
Drug of the present invention has no toxic side effect, easy to use.
The above-mentioned detailed description that the Chinese medicine composition for preventing and treating duckling duck virus hepatitis is carried out referring to embodiment,
It is illustrative without being restrictive, several embodiments can be enumerated according to limited range, therefore do not departing from this hair
Change and modification under bright general plotting should belong within protection scope of the present invention.
Claims (2)
1. a kind of Chinese medicine composition for treating duck virus hepatitis, it is characterised in that it is made by weight by following Chinese medicinal ingredients
It is standby to form: 5 ~ 6 parts of Herba Euphorbiae Humifusae, 5 ~ 6 parts of Asian puccoon, 1 ~ 3 part of Cortex Phellodendri, 1 ~ 3 part of oriental wormwood, 1 ~ 3 part of radix bupleuri, 1 ~ 3 part of peppermint, hawthorn 1 ~ 3
Part, 1 ~ 3 part of honeysuckle, 1 ~ 3 part of Radix Glycyrrhizae and poplar bark lipoid are made, the weight ratio in admixing medical solutions of the poplar bark lipoid
For 0.1-0.5%, the admixing medical solutions are remaining composition in addition to poplar bark lipoid in water of 4 times of weight in pharmaceutical composition
Solution after decoction is made after then adding poplar bark lipoid.
2. a kind of preparation method of Chinese medicine composition for treating duck virus hepatitis described in claim 1, it is characterised in that will
5 ~ 6 parts of Herba Euphorbiae Humifusaes, 5 ~ 6 portions of Asian puccoons, 1 ~ 3 portion of Cortex Phellodendri, 1 ~ 3 portion of oriental wormwood, 1 ~ 3 part of radix bupleuri, 1 ~ 3 portion of peppermint, 1 ~ 3 part of mountain
Short, bristly hair or beard, 1 ~ 3 part of honeysuckle, 1 ~ 3 portion of Radix Glycyrrhizae, add 4 times of weight in the water of pharmaceutical composition, and boiled water is decocted half an hour, cooling, filter to get filtrate,
Poplar bark lipoid is added, the weight ratio of poplar bark lipoid content is controlled in 0.1-0.5%, stirred.
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Title |
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中医药防制禽病前景广阔;张国红;《中国禽业导刊》;19991231;第16卷(第18期);第13页 |
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