CN104173660A - Composition for treating retained placenta in cattle and preparation method of composition - Google Patents
Composition for treating retained placenta in cattle and preparation method of composition Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating retained placenta in cattle. The composition is prepared from the following components in parts by weight: 10 to 20 parts of angelica sinensis, 10 to 20 parts of impatiens balsamina, 10 to 20 parts of astragalus membranaceus, 10 to 20 parts of codonopsis pilosula, 10 to 20 parts of winged euonymus twig, 10 to 15 parts of leonurus, 10 to 15 parts of sunflower receptacle, 10 to 15 parts of radix achyranthis bidentatae, 10 to 15 parts of ligusticum wallichii, 10 to 15 parts of rhizoma atractylodis macrocephalae, 10 to 15 parts of nutgrass galingale rhizome, 5 to 10 parts of licorice root, 5 to 10 parts of borax and 5 to 10 parts of asarum sieboldii. The composition has the functions of strengthening uterine contraction, inhibiting bacteria, resisting inflammation and enhancing immunity by effectively combining the functions of the five core medicinal materials comprising the angelica sinensis, the impatiens balsamina, the astragalus membranaceus, the codonopsis pilosula and the winged euonymus twig and the nine auxiliary medicinal materials comprising the radix achyranthis bidentatae according to a matching method, so that the cure rate of the retained placenta in the cattle is effectively improved, the morbidity of endometritis and subinvolution of uterus is reduced, and thus the fertility of the cattle is improved. As a result, the composition provided by the invention has an important significance for promoting the healthy development of cattle husbandry.
Description
Technical field
The invention belongs to animal medicinal composition, be specifically related to a kind of Chinese medicine composition and preparation method thereof, relate in particular to a kind of cattle placenta Chinese medicine composition under not and preparation method thereof for the treatment of.
Background technology
Cattle placenta does not refer to down still undischarged disease of 12 hours its point of puerperiums afterbirth, and different regions, time and the sickness rate of cattle placenta in season under are not different.Under normal circumstances, the sickness rate of milch cow placenta retention is 3～5%.At present, the cause of disease of cattle placenta under is not also fully aware of, permitted many factors can cause cattle placenta not under, for example: Placenta Hominis immaturity or aging, puerperal inertia of uterus, pregnancy duration lack and in motion, feedstuff, lack minerals and vitamins, nutrient imbalance and have a delicate constitution etc.In addition, metritis, Brucella etc. also can be caused a disease.The traditional Chinese medical science thinks, cattle placenta is not down due to the deficiency of vital energy, blood stasis, cold coagulation and the scorchingly hot born of the same parents of wound.
The clinical manifestation that placenta retention is suffered from cattle is: hogback is exerted duty, fervescence, loss of appetite, spiritual depressed.If at high temperature season, the retained afterbirth time is slightly long, and spoilage product easily causes suffering from cattle fervescence after being absorbed by cattle body, lochia band frowziness, and be mingled with corrupt afterbirth and fragment of tissue.Because intrauterine environment very easily makes bacterial reproduction, therefore all secondary endometritis of the trouble cattle of most placenta retention, finally because can not conceived eliminating.
At present, the not lower method for the treatment of cattle placenta is a lot, has been summed up: 1. use and shrink uterus preparation and promote afterbirth discharge, as estradiol benzoate, ergometrine, oxytocin and prostaglandin; 2. intrauterine throwing antibiotic and antiseptic are protected from infection; 3. peeling operation takes out afterbirth.These methods have certain therapeutic effect, but also have shortcomings: the half-life of (1) uterine contraction preparation is of short duration, and be all no more than 30 minutes action time, and therapeutic effect is indefinite; (2) use antibiotic easily to produce Resistant strain, antiseptic easily damages endometrium and upsets uterus defensive enginery, can cause the reduction of milk quality due to drug residue simultaneously; (3) peeling operation has strict time restriction, must carry out 12 hours puerperal (after 12 hours, palm is difficult to pass through cervix uteri), and serious to endometrial impairment, be easy to infect, and be unfavorable for the involution of uterus.Therefore, application Chinese medicine or to explore other effective Therapeutic Method that have no side effect significant.
Summary of the invention
For the lower problem existing of above-mentioned treatment cattle placenta, the invention provides a kind of composition and method of making the same of cattle placenta under not for the treatment of, reached the effect that increases substantially the cure rate of cattle placenta under not, and with low cost, have no side effect.The invention also discloses the preparation method of described Chinese medicine composition.
Technical scheme of the present invention is: the Chinese medicine composition for the treatment of cattle placenta under not, meter, composed of the following components: 10-20 part Radix Angelicae Sinensis, 10-20 part Semen Impatientis, 10-20 part Radix Astragali, 10-20 part Radix Codonopsis, 10-20 part Ramulus Euonymi, 10-15 part Herba Leonuri, 10-15 part Receptaculum Helianthi, 10-15 part Radix Achyranthis Bidentatae, 10-15 part Rhizoma Chuanxiong, 10-15 part Rhizoma Atractylodis Macrocephalae, 10-15 part Rhizoma Cyperi, 5-10 part Radix Glycyrrhizae, 5-10 part Borax, 5-10 part Herba Asari by weight.
The preparation method of the Chinese medicine composition filling agent for the treatment of cattle placenta under not, comprises the following steps:
1. prepare medicament: take respectively 10-20 part Radix Angelicae Sinensis, 10-20 part Semen Impatientis, 10-20 part Radix Astragali, 10-20 part Radix Codonopsis, 10-20 part Ramulus Euonymi, 10-15 part Herba Leonuri, 10-15 part Receptaculum Helianthi, 10-15 part Radix Achyranthis Bidentatae, 10-15 part Rhizoma Chuanxiong, 10-15 part Rhizoma Atractylodis Macrocephalae, 10-15 part Rhizoma Cyperi, 5-10 part Radix Glycyrrhizae, 5-10 part Borax, 5-10 part Herba Asari.
2. boil medicament: in the medicament 1. preparing to step, add normal-temperature water 2500～3000ml, soak 30 minutes, after intense fire boils, then 45～55 minutes at a simmer, the medicinal residues that filter, pressurize, obtain medicinal liquid one time; Again to filter after medicinal residues in add 2000～2500ml water, 45～50 minutes at a simmer, filter, extruding medicinal residues, obtain secondary medicinal liquid, merge the medicinal liquid of twice, obtain medicinal liquid I.
3. process medicinal liquid: by medicinal liquid I centrifugation, obtain medicinal liquid II; Then adopt ethanol precipitation to carry out extracted twice and refine obtaining medicinal liquid III to medicinal liquid II, to remove the impurity such as starch, protein and some polysaccharide.Wherein, extracting for the first time and adopting concentration is the ethanol of 50%～60% (v/v), centrifuging and taking supernatant, and ethanol is reclaimed in distilling under reduced pressure; Extract for the second time the ethanol that adopts concentration 75%～85% (v/v), centrifuging and taking supernatant, ethanol is reclaimed in distilling under reduced pressure.In gained solution, add 15ml Tween 80, reach 150ml with water for injection regulator solution volume, boiling sterilization, obtains clarifying medicinal liquid IV, i.e. the Chinese medicine composition filling agent of potion treatment cattle placenta under not.
The using method of the not lower Chinese medicine composition filling agent for the treatment of cattle placenta: filling agent is heated to 35～40 DEG C, and to uterine perfusion, pour into dosage is 150ml at every turn, once a day with the flexible rubber hose of connection syringe.
Core drug in the Chinese medicine composition for the treatment of cattle placenta of the present invention under not comprises Radix Angelicae Sinensis, Semen Impatientis, the Radix Astragali, Radix Codonopsis, Ramulus Euonymi: (1) Radix Angelicae Sinensis can shrink uterine smooth muscle, anti-bacteria breeding, can promote afterbirth discharge and reduce and infect.(2) Semen Impatientis on the one hand can excited uterus, strengthen frequency of uterine contraction and tension force, there is on the other hand bacteriostasis, and with Radix Angelicae Sinensis synergism.(3) Radix Astragali possesses bacteriostasis efficacy, can also heart tonifying diuresis.(4) Radix Codonopsis has enhancing immunity, blood vessel dilating, blood pressure lowering, improves microcirculation and strengthens the effects such as hemopoietic function; The Radix Astragali and Radix Codonopsis can be worked in coordination with and be strengthened resistance and the immunity of suffering from cattle.(5) Ramulus Euonymi can increase coronary flow, improves myocardial metabolism, and staphylococcus aureus is had to inhibitory action; Ramulus Euonymi not only can have synergism with the Radix Astragali, Radix Codonopsis like this, also can coordinate Semen Impatientis antibacterial.
Except above-mentioned core drug, in compositions, also has other ancillary drug.Total Saponin in Radix Achyranthis Bidentatae all has strong contraction to isolated uterine with in body uterus; Leonurine in Herba Leonuri can be antibacterial, heart tonifying and contracting palace, and the two can assist Radix Angelicae Sinensis and Semen Impatientis to discharge afterbirth, and strengthens uterus anti-infection ability.Rhizoma Chuanxiong has calmness, pain relieving, contracting palace and bacteriostasis; Herba Asari can antipyretic-antalgic; Rhizoma Cyperi can be improved the threshold of pain, and Herba Asari and Rhizoma Cyperi can be worked in coordination with Rhizoma Chuanxiong analgesia.Sunflower plate has cardiotonic; The Rhizoma Atractylodis Macrocephalae can strengthen the phagocytic activity of reticuloendothelial system and improve immunity, also has bacteriostasis, so Rhizoma Chuanxiong, sunflower plate, the Rhizoma Atractylodis Macrocephalae and Radix Glycyrrhizae can assist the Radix Astragali, Radix Codonopsis to improve immunity, improves resistance infection.In addition, Radix Glycyrrhizae, except possessing effect of antiinflammatory, enhancing human body immunity power, also plays flavored action to Chinese medicine composition.Borax all has inhibitory action to escherichia coli, bacillus pyocyaneus, anthrax bacillus, shigella flexneri, shigella, Bacillus typhi, Salmonella paratyphi, Bacillus proteus, staphylococcus and Candida albicans, can also suppress diphtheria corynebacterium, cattle type Brucella, Diplococcus pneumoniae, meningococcus and Hemolytic streptococcus.
The pharmacological action of various Chinese medicines in the Chinese medicine composition for the treatment of cattle placenta of the present invention under not:
(1) Radix Angelicae Sinensis: possessing enriches blood invigorates blood circulation, effect of menstruction regulating and pain relieving.Radix Angelicae Sinensis has " amphicheirality " to the effect in uterus, and the excited uterine smooth muscle of its water solublity non-volatile matter mass-energy, shrinks uterus, and its volatile ingredient has the uterus of minimizing rhythmicity to shrink, make its effect of relaxing, but the two is taking excited composition as main.Dysentery bacterium, Bacillus typhi, escherichia coli, Hemolytic streptococcus are all had to certain inhibitory action.
(2) Semen Impatientis: possess and invigorate blood circulation, dispel the wind and effect of pain relieving.Semen Impatientis has obvious excitation to uterus, contraction frequency increase, tension force is strengthened and even occur tetanic contraction.Its water decoction all has inhibitory action in various degree to staphylococcus aureus, Hemolytic streptococcus, bacillus pyocyaneus, shigella flexneri, sonne bacillus and Bacillus typhi.
(3) Radix Astragali: possess effect of invigorating QI to consolidate the body surface resistance, diuresis poison holding and evacuation of pus, can be used for treating that the deficiency of vital energy is weak, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis and the metrorrhagia of having blood in stool.The Radix Astragali can be strengthened heart contraction, and the heart of exhaustion is had to cardiotonic; Can make coronary vasodilator and the expansion of whole body peripheral vessel, thereby make blood pressure drops.The Radix Astragali also has diuresis, can reduce the permeability of blood capillary, can prevent the phenomenon of the increased capillary permeability that histamine, chloroform cause, and the pathological phenomenon that can make capillary fragility that x-ray causes increase is normal again.In addition, the Radix Astragali has inhibitory action to dysentery bacterium, anthrax bacillus, Hemolytic streptococcus, Diplococcus pneumoniae, staphylococcus aureus etc.
(4) Radix Codonopsis: the effect that possesses invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.Radix Codonopsis, containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, Saponin and Alkaloid, can make peripheral vasodilation, therefore there is hypotensive effect.Radix Codonopsis has excitation to nervous system, the resistance of energy enhancing body.Radix Codonopsis can make erythrocyte increase, leukopenia, has the effect of rising blood glucose, can promote blood coagulation.
(5) Ramulus Euonymi: possess invigorate blood circulation, the function of removing blood stasis with potent drugs, can suffer from abdominal pain for postnatal blood stasis.Its water decoction can increase the intake of mouse cardiac muscle to Rb86, and explanation can increase coronary flow, improves myocardial metabolism; In addition, decoct also has inhibitory action to staphylococcus aureus.
(6) Herba Leonuri: possess the function of blood circulation promoting and blood stasis dispelling, can be used for the treatment of vaginal bleeding during pregnancy difficult labour, retention of placenta etc.Herba Leonuri decoct and contained leonurine are all excitation to the uterus of laboratory animal.Leonurine is to escherichia coli, dysentery bacterium, achorion schoenleinii, and Pilus Caprae seu Ovis sample sporidiole bacteria, epidermophyton rubrum and starlike nocadia all have inhibitory action.Leonurine can improve coronary circulation and cardioprotection, and low dose of leonurine has the effect of the heart contraction of enhancing, when heavy dose of, is inhibition phenomenon.
(7) Receptaculum Helianthi: possess the function of heat clearing away suppressing the hyperactive liver, analgesic hemostatic, can be used for the treatment of abdominal pain and metrorrhagia.Sunflower plate extractum dialysis solution has double influence to heart, and extractum dialysis solution had both contained the composition to Cardiac depression, also has the composition of heart tonifying.
(8) Radix Achyranthis Bidentatae: possess the function of invigorating the liver and kidney, bone and muscle strengthening and promoting blood circulation to restore menstrual flow, can be used for the treatment of the diseases such as abdominal pain due to blood stasis in puerperal, retention of placenta and traumatic injury.Achyranthes Bidentata Saponins has strong contraction effect of uterus, and it shows as, and tension force increases, contractive amplitude strengthens and frequency is accelerated.
(9) Rhizoma Chuanxiong: possess the function of blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression and wind-expelling pain-stopping, can be used for the treatment of the diseases such as the stagnant and lump in the abdomen lump of the stasis of blood in puerperal.Rhizoma Chuanxiong has obvious sedation to central nervous system, and a small amount of Rhizoma Chuanxiong volatile oil can suppress the activity of animal brain, excited medulla oblongata respiratory center, vasomotor center and spinal reflex maincenter.When Rhizoma Chuanxiong decoct trace, can make conceived Rabbit Uterus tension force increase, shrink and strengthen; Instead in a large number make metroparalysis and shrink to stop.Rhizoma Chuanxiong has inhibitory action to large intestine, dysentery (Song Nei Shi), distortion, green pus, typhoid fever, Salmonella paratyphi and vibrio cholera etc.
(10) Rhizoma Atractylodis Macrocephalae: possess invigorating the spleen and benefiting QI, dampness diuretic and the antiabortive effect of hidroschesis, can be for diseases such as frequent fetal movement.The Rhizoma Atractylodis Macrocephalae can strengthen the phagocytic function of reticuloendothelial system, improves lymhocyte transformation rate and natural rosette forming rate, promotes cellular immune function, and can obviously increase the amount of IgG.Rhizoma Atractylodis Macrocephalae decoct also all has inhibitory action to meningococcus, Bacillus typhi, paratyphoid bacillus A, shigella flexneri, escherichia coli, bacillus pyocyaneus, acrothesium floccosum, star nocardia etc.
(11) Rhizoma Cyperi: possess the resolving depression of regulating the flow of vital energy, the antiabortive effect of pain relieving, can improve the toleration of body to pain.5% Rhizoma Cyperi extractum can suppress the contraction of laboratory animal isolated uterine, has the effect of the uterus muscle tension force that relaxes.Nutgrass galingale oil has inhibitory action to staphylococcus aureus, the effect that the aqueous solution of its total alkaloids, glycoside, flavonoid and phenolic compound has heart tonifying and reduces blood pressure.
(12) Radix Glycyrrhizae: possess effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing and relieving spasm to stop pain, can be used for the treatment of the anxious pain of fatigue and weakness, gastral cavity abdomen extremity contraction, can also cushion toxicity and strong etc.Radix Glycyrrhizae has antiinflammatory, antianaphylaxis reaction, inducement interferon, enhancing NK cytoactive, presents the effect of adrenocortical hormone sample, can enhancing human body immunity power.Poisoning and the diphtheria toxin, diphtherotoxin of glycyrrhizic acid to food, interior metabolism product, tetanus toxin, snake venom etc. have stronger Detoxication.Glycyrrhizic acid and enoxolone and its esters have obvious antidiuretic activity.
(13) Borax: external has heat-clearing and toxic substances removing, detumescence and antiseptical effect, can be for acute tonsillitis, pharyngolaryngitis, laryngopharynx swelling and pain, aphtha of the mouth and tongue, stomatitis, gingivitis, otitis media, conjunctival congestion and swelling pain and tinea versicolor.Borax all has inhibitory action to escherichia coli, bacillus pyocyaneus, anthrax bacillus, shigella flexneri, shigella, Bacillus typhi, Salmonella paratyphi, Bacillus proteus and staphylococcus, Candida albicans, can also suppress diphtheria corynebacterium, cattle type Brucella, Diplococcus pneumoniae, meningococcus and Hemolytic streptococcus etc.There are convulsion and antiepileptic action.
(14) Herba Asari: possess effect of the cold expelling that induces sweat, wind-expelling pain-stopping, can dispel the wind for cold expelling sensible with pain relieving.Low dose of volatile oil has sedation, and its water decoction also has analgesia, antitussive and refrigeration function.Heavy dose of volatile oil can make the excitement of animal initial stage, paralysis, voluntary movement and respiratory movement weaken gradually then, and areflexia, eventually because respiratory paralysis is dead.There is local anesthesia effect and there is to inhibitory action in uterus.In vitro tests, to gram positive bacteria, dysentery bacterium and Bacillus typhi etc., has remarkable antibacterial action.
Beneficial effect of the present invention:
(1) Chinese medicine composition of the present invention combines effect of the auxiliary medical material of nine tastes such as Radix Angelicae Sinensis, Semen Impatientis, the Radix Astragali, Radix Codonopsis and Ramulus Euonymi five tastes core medical material and Radix Achyranthis Bidentatae effectively, and the method for employing coupling, realize it and strengthened uterine contraction, antibacterial anti-inflammatory, enhancing immunity function, effectively improves the cure rate of cattle placenta under not, reduces the sickness rate of endometritis and subinvolution of uterus, improve fertility, have great importance to promoting cattle-raising to develop in a healthy way;
(2) Chinese medicine composition of the present invention draw materials extensive, with low cost, easy to use and safe and effective, the effect of there is anti-inflammation, shrinking uterus, promoting blood circulation and stopping pain, enhancing immunity, QI invigorating dissipating blood stasis and pure and impure putrefaction removing; In treatment placenta retention, can also improve the resistance against diseases of healthy cattle, prevention uterus in puerperal is slow, the probability that cattle uterus infects is cured in minimizing, shortens the time in calving interval;
(3) Chinese medicine composition of the present invention efficiently solves the not good problem of existing treatment placenta retention technology therapeutic effect, avoid the problems such as the drug residue, bacterial drug resistance and the uterus egodefense function upset that produce while using hormone and antibiotic therapy, and the damage endometrium producing while adopting peeling operation ruling by law to treat, be easy to the problems such as infection;
(4) preparation method that Chinese medicine composition of the present invention mates by employing obtains filling agent, and adopts the mode administration of intrauterine perfusion, and therefore administration is more convenient, acts on more direct.Adopt this medicament to treat altogether 137 routine milch cows and 5 routine cattle cattle placenta do not descend case, result is cured respectively 134 examples (not following the trail of 3 examples of therapeutic outcome) and 5 examples, and cure rate is respectively 97.8% and 100%.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further.
Embodiment 1:
The Chinese medicine composition for the treatment of cattle placenta under not, meter, composed of the following components: 10g Radix Angelicae Sinensis, 15g Semen Impatientis, the 20g Radix Astragali, 10g Radix Codonopsis, 15g Ramulus Euonymi, 15g Herba Leonuri, 10g Receptaculum Helianthi, 12g Radix Achyranthis Bidentatae, 15g Rhizoma Chuanxiong, the 10g Rhizoma Atractylodis Macrocephalae, 13g Rhizoma Cyperi, 10g Radix Glycyrrhizae, 5g Borax, 8g Herba Asari by weight.
The preparation method of the Chinese medicine composition filling agent for the treatment of cattle placenta under not, comprises the following steps:
1. prepare medicament: take respectively 10g Radix Angelicae Sinensis, 15g Semen Impatientis, the 20g Radix Astragali, 10g Radix Codonopsis, 15g Ramulus Euonymi, 15g Herba Leonuri, 10g Receptaculum Helianthi, 12g Radix Achyranthis Bidentatae, 15g Rhizoma Chuanxiong, the 10g Rhizoma Atractylodis Macrocephalae, 13g Rhizoma Cyperi, 10g Radix Glycyrrhizae, 5g Borax, 8g Herba Asari.
2. boil medicament: in the medicament 1. preparing to step, add normal-temperature water 2500ml, soak 30 minutes, after intense fire boils, then 45 minutes at a simmer, the medicinal residues that filter, pressurize, obtain medicinal liquid one time; Again to filter after medicinal residues in add 2500ml water, 50 minutes at a simmer, filter, extruding medicinal residues, obtain secondary medicinal liquid, merge the medicinal liquid of twice, obtain medicinal liquid I.
3. process medicinal liquid: by medicinal liquid I centrifugation, obtain medicinal liquid II; Then adopt ethanol precipitation to carry out extracted twice and refine obtaining medicinal liquid III to medicinal liquid II, to remove the impurity such as starch, protein and some polysaccharide.Wherein, extracting for the first time and adopting concentration is the ethanol of 50% (v/v), centrifuging and taking supernatant, and ethanol is reclaimed in distilling under reduced pressure; Extracting for the second time and adopting concentration is the ethanol of 85% (v/v), centrifuging and taking supernatant, and ethanol is reclaimed in distilling under reduced pressure.In gained solution, add 15ml Tween 80, reach 150ml with water for injection regulator solution volume, boiling sterilization, obtains clarifying medicinal liquid IV, i.e. the Chinese medicine composition filling agent of potion treatment cattle placenta under not.
The using method of the not lower Chinese medicine composition filling agent for the treatment of cattle placenta: filling agent is heated to 35～40 DEG C, and to uterine perfusion, pour into dosage is 150ml at every turn, once a day with the flexible rubber hose of connection syringe.
Treatment case: in August calendar year 2001, have 3 cow heads, 12 hours puerperal not to discharge yet afterbirth before and after certain cattle farm.Suffer from cattle and show as the back of a bow, exert duty, part afterbirth falls in outside vaginal orifice.Gather intrauterine sample and do bacteriology's cultivation, find that there is streptococcus, staphylococcus, escherichia coli, bacillus cereus, corynebacterium and bacillus pyocyaneus.When beginning, use estradiol benzoate (20mg) intramuscular injection, oxytocin injection (60 unit) again after half an hour, has not yet to see afterbirth for after administration 14 hours and discharges.Use above-mentioned traditional Chinese medicine composition for treating instead, 1 dose of every day, have 2 examples to discharge afterbirth after using 2 doses, after another example is used 3 doses, discharge afterbirth, cure rate 100%.3 cow head involution of uterus time averages are 32 days, and after rutting, 3 cow heads are gestation all again.
Embodiment 2:
The Chinese medicine composition for the treatment of cattle placenta under not, meter, composed of the following components: 15g Radix Angelicae Sinensis, 20g Semen Impatientis, the 10g Radix Astragali, 15g Radix Codonopsis, 20g Ramulus Euonymi, 10g Herba Leonuri, 12g Receptaculum Helianthi, 15g Radix Achyranthis Bidentatae, 10g Rhizoma Chuanxiong, the 13g Rhizoma Atractylodis Macrocephalae, 15g Rhizoma Cyperi, 5g Radix Glycyrrhizae, 8g Borax, 10g Herba Asari by weight.
The preparation method of the Chinese medicine composition filling agent for the treatment of cattle placenta under not, comprises the following steps:
1. prepare medicament: take respectively 15g Radix Angelicae Sinensis, 20g Semen Impatientis, the 10g Radix Astragali, 15g Radix Codonopsis, 20g Ramulus Euonymi, 10g Herba Leonuri, 12g Receptaculum Helianthi, 15g Radix Achyranthis Bidentatae, 10g Rhizoma Chuanxiong, the 13g Rhizoma Atractylodis Macrocephalae, 15g Rhizoma Cyperi, 5g Radix Glycyrrhizae, 8g Borax, 10g Herba Asari.
2. boil medicament: in the medicament 1. preparing to step, add normal-temperature water 3000ml, soak 30 minutes, after intense fire boils, then 55 minutes at a simmer, the medicinal residues that filter, pressurize, obtain medicinal liquid one time; Again to filter after medicinal residues in add 2000ml water, 45～50 clocks at a simmer, filter, extruding medicinal residues, obtain secondary medicinal liquid, merge the medicinal liquid of twice, obtain medicinal liquid I.
3. process medicinal liquid: by medicinal liquid I centrifugation, obtain medicinal liquid II; Then adopt ethanol precipitation to carry out extracted twice and refine obtaining medicinal liquid III to medicinal liquid II, to remove the impurity such as starch, protein and some polysaccharide.Wherein, extracting for the first time and adopting concentration is the ethanol of 60% (v/v), centrifuging and taking supernatant, and ethanol is reclaimed in distilling under reduced pressure; Extracting for the second time and adopting concentration is the ethanol of 75% (v/v), centrifuging and taking supernatant, and ethanol is reclaimed in distilling under reduced pressure.In gained solution, add 15ml Tween 80, reach 150ml with water for injection regulator solution volume, boiling sterilization, obtains clarifying medicinal liquid IV, i.e. the Chinese medicine composition filling agent of potion treatment cattle placenta under not.
Treatment case: 2003, use above-mentioned medicament to treat altogether 8 placenta retention in certain cattle farm and suffer from cattle.According to experience in the past, find to suffer from after cattle, the treatment step of having saved estradiol benzoate and oxytocin, is directly used above-mentioned traditional Chinese medicine composition for treating, 1 dose of every day, except 1 cattle was discharged afterbirth at the 5th day, other 7 suffer from cattle all in use medicine in 3 days, discharge afterbirth, cure rate 100%, suffering from the involution of uterus time average of cattle is 33.6 days, after rutting, 8 cattle are all pregnant again.
Embodiment 3:
The Chinese medicine composition for the treatment of cattle placenta under not, meter, composed of the following components: 20g Radix Angelicae Sinensis, 10g Semen Impatientis, the 15g Radix Astragali, 20g Radix Codonopsis, 10g Ramulus Euonymi, 12g Herba Leonuri, 15g Receptaculum Helianthi, 10g Radix Achyranthis Bidentatae, 12g Rhizoma Chuanxiong, the 15g Rhizoma Atractylodis Macrocephalae, 10g Rhizoma Cyperi, 8g Radix Glycyrrhizae, 10g Borax, 5g Herba Asari by weight.
The preparation method of the Chinese medicine composition filling agent for the treatment of cattle placenta under not, comprises the following steps:
1. prepare medicament: take respectively 20g Radix Angelicae Sinensis, 10g Semen Impatientis, the 15g Radix Astragali, 20g Radix Codonopsis, 10g Ramulus Euonymi, 12g Herba Leonuri, 15g Receptaculum Helianthi, 10g Radix Achyranthis Bidentatae, 12g Rhizoma Chuanxiong, the 15g Rhizoma Atractylodis Macrocephalae, 10g Rhizoma Cyperi, 8g Radix Glycyrrhizae, 10g Borax, 5g Herba Asari.
2. boil medicament: in the medicament 1. preparing to step, add normal-temperature water 2800ml, soak 30 minutes, after intense fire boils, then 50 minutes at a simmer, the medicinal residues that filter, pressurize, obtain medicinal liquid one time; Again to filter after medicinal residues in add 2200ml water, 48 minutes at a simmer, filter, extruding medicinal residues, obtain secondary medicinal liquid, merge the medicinal liquid of twice, obtain medicinal liquid I.
3. process medicinal liquid: by medicinal liquid I centrifugation, obtain medicinal liquid II; Then adopt ethanol precipitation to carry out extracted twice and refine obtaining medicinal liquid III to medicinal liquid II, to remove the impurity such as starch, protein and some polysaccharide.Wherein, extracting for the first time and adopting concentration is the ethanol of 55% (v/v), centrifuging and taking supernatant, and ethanol is reclaimed in distilling under reduced pressure; Extracting for the second time and adopting concentration is the ethanol of 80% (v/v), centrifuging and taking supernatant, and ethanol is reclaimed in distilling under reduced pressure.In gained solution, add 15ml Tween 80, reach 150ml with water for injection regulator solution volume, boiling sterilization, obtains clarifying medicinal liquid IV, i.e. the Chinese medicine composition filling agent of potion treatment cattle placenta under not.
Treatment case: 2002, a cattle of Lee of peasant household raising was ill.Calving of this cattle of main suit 2 days, gives birth to twins calf, after this spiritual depressed, and the back of a bow, often does the posture of urinating.Check and find, this trouble cattle spirit is depressed, and 39.4 DEG C of body temperature, 61 beats/min, pulse are breathed 32 beats/min.Examination per vagina discovery, part retained afterbirth is in intravaginal, and atresia of cervix, can pass through two fingers reluctantly, is diagnosed as placenta retention.In vein fluid infusion, adopt above-mentioned filling agent to treat, be used in conjunction 2 doses, afterbirth is discharged, and sb.'s illness took a favorable turn.
Embodiment 4:
The not lower Chinese medicine composition for the treatment of cattle placenta, counts by weight, composed of the following components: Radix Angelicae Sinensis 15g, Semen Impatientis 15g, Radix Astragali 15g, Radix Codonopsis 15g, Ramulus Euonymi 15g, Herba Leonuri 10g, Receptaculum Helianthi 10g, Radix Achyranthis Bidentatae 10g, Rhizoma Chuanxiong 10g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Cyperi 10g, Radix Glycyrrhizae 5g, Borax 5g, Herba Asari 5g.
The preparation method of the Chinese medicine composition filling agent for the treatment of cattle placenta under not, comprises the following steps:
1. prepare medicament: take respectively Radix Angelicae Sinensis 15g, Semen Impatientis 15g, Radix Astragali 15g, Radix Codonopsis 15g, Ramulus Euonymi 15g, Herba Leonuri 10g, Receptaculum Helianthi 10g, Radix Achyranthis Bidentatae 10g, Rhizoma Chuanxiong 10g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Cyperi 10g, Radix Glycyrrhizae 5g, Borax 5g, Herba Asari 5g.
2. boil medicament: in the medicament 1. preparing to step, add normal-temperature water 2800ml, soak 30 minutes, after intense fire boils, then 50 minutes at a simmer, the medicinal residues that filter, pressurize, obtain medicinal liquid one time; Again to filter after medicinal residues in add 2200ml water, 48 minutes at a simmer, filter, extruding medicinal residues, obtain secondary medicinal liquid, merge the medicinal liquid of twice, obtain medicinal liquid I.
3. process medicinal liquid: by medicinal liquid I centrifugation, obtain medicinal liquid II; Then adopt ethanol precipitation to carry out extracted twice and refine obtaining medicinal liquid III to medicinal liquid II, to remove the impurity such as starch, protein and some polysaccharide.Wherein, extract for the first time and adopt the ethanol (v/v) that concentration is 55%, centrifuging and taking supernatant, ethanol is reclaimed in distilling under reduced pressure; Extracting for the second time and adopting concentration is the ethanol of 80% (v/v), centrifuging and taking supernatant, and ethanol is reclaimed in distilling under reduced pressure.In gained solution, add 15ml Tween 80, reach 150ml with water for injection regulator solution volume, boiling sterilization, obtains clarifying medicinal liquid IV, i.e. the Chinese medicine composition filling agent of potion treatment cattle placenta under not.
Treatment case: 2008, the cattle that the Zhang of peasant household raises was ill.Calving of this cattle of main suit 2 days, after this spiritual depressed, hunchbacked, exert duty, part afterbirth falls in outside vaginal orifice.Check and find, this trouble cattle spirit is depressed, and 39.8 DEG C of body temperature, 65 beats/min, pulse are breathed 35 beats/min.In vein fluid infusion, adopt above-mentioned filling agent to treat, be used in conjunction 2 doses, afterbirth is discharged, and sb.'s illness took a favorable turn.
In May, 2004 to 2010 year JIUYUE, the author is successively by present composition treatment milch cow placenta retention case 125 examples, cattle 4 examples, age is between 3～7 years old, disease time from 12 hours to 72 hours puerperal not etc., through above-mentioned composition treatment, wherein have 122 routine milch cows and 5 routine cattlees to cure, cure rate 97.8% and 100%, all the other 3 examples fail to track its therapeutic effect.
Table 1 uses traditional Chinese medicine composition for treating milk of the present invention (Huang) cattle placenta not descend result statistics
Claims (3)
1. the Chinese medicine composition for the treatment of cattle placenta under not, it is characterized in that: meter by weight, composed of the following components: 10-20 part Radix Angelicae Sinensis, 10-20 part Semen Impatientis, 10-20 part Radix Astragali, 10-20 part Radix Codonopsis, 10-20 part Ramulus Euonymi, 10-15 part Herba Leonuri, 10-15 part Receptaculum Helianthi, 10-15 part Radix Achyranthis Bidentatae, 10-15 part Rhizoma Chuanxiong, 10-15 part Rhizoma Atractylodis Macrocephalae, 10-15 part Rhizoma Cyperi, 5-10 part Radix Glycyrrhizae, 5-10 part Borax, 5-10 part Herba Asari.
2. the preparation method of the Chinese medicine composition filling agent for the treatment of cattle placenta under not, is characterized in that: comprise the following steps:
1. prepare medicament: take respectively 10-20 part Radix Angelicae Sinensis, 10-20 part Semen Impatientis, 10-20 part Radix Astragali, 10-20 part Radix Codonopsis, 10-20 part Ramulus Euonymi, 10-15 part Herba Leonuri, 10-15 part Receptaculum Helianthi, 10-15 part Radix Achyranthis Bidentatae, 10-15 part Rhizoma Chuanxiong, 10-15 part Rhizoma Atractylodis Macrocephalae, 10-15 part Rhizoma Cyperi, 5-10 part Radix Glycyrrhizae, 5-10 part Borax, 5-10 part Herba Asari;
2. boil medicament: in the medicament 1. preparing to step, add normal-temperature water 2500～3000ml, soak 30 minutes; After intense fire boils, adopt 45～55 minutes at a simmer, filter, obtain medicinal residues and a medicinal liquid; In medicinal residues, add 2000～2500ml water, adopt 45～55 minutes at a simmer, filter, obtain secondary medicinal liquid; Medicinal liquid and secondary medicinal liquid are merged and obtain medicinal liquid I;
3. process medicinal liquid: the medicinal liquid I centrifugation that 2. step is obtained, the medicinal liquid II obtaining, adopt ethanol precipitation to carry out double extraction to medicinal liquid II, extracting the concentration of alcohol adopting is for the first time 50%～60% (volumetric concentration), extracting the concentration of alcohol adopting is for the second time 75%～85% (volumetric concentration), obtains medicinal liquid III; In medicinal liquid III, add 10-20ml Tween 80, be then diluted with water to 150ml, after boiling sterilization, obtain clarifying medicinal liquid IV, be i.e. the Subinvoluted Chinese medicine composition filling agent of potion treatment cattle uterus.
3. the using method of the not lower Chinese medicine composition filling agent for the treatment of cattle placenta, is characterized in that: comprise the following steps: cattle is suffered from Baoding, and adopting the flexible rubber hose that connects syringe is the medicine liquid irrigation injection deep rectum of 35～40 DEG C by temperature; Each consumption is 150ml, once a day.
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Application publication date: 20141203 |