CN104547865A - Application of traditional Chinese medicine preparation in preparing medicine for treating senile dementia - Google Patents
Application of traditional Chinese medicine preparation in preparing medicine for treating senile dementia Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine and relates to an application of a traditional Chinese medicine preparation in preparing a medicine for treating senile dementia. Traditional Chinese medicine preparation comprises the following principal raw materials: astragalus mongholicus, poria cocos, bulbus fritilariae, rhizoma corydalis, fennel, platycodon grandiflorum, fructus aurantii immaturus, mulberry bark, caulis bambusae in taeniam, a turtle shell, a prepared rehmannia root, radix asparagi, rhizoma anemarrhenae, radix aucklandiae, cortex magnoliae officinalis, ramulus cinnamomi, fructus amomi, gentiana macrophylla and liquorice. The traditional Chinese medicine preparation takes effect quickly, has a good effect, treats both principal and secondary aspects of the senile dementia, integrates conditioning and treatment, has a continuous treatment effect and no toxic or side effects in treating the senile dementia, has an effect of conditioning a patient body, improves an immunologic function of a patient, and is simple and convenient in preparation technology, stable in efficacy, good in universality and easy to popularize and apply.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to the purposes of a kind of Chinese medicine preparation in preparation treatment senile dementia.
Background technology
In the modern times, China has stepped into senescence society, and the number of old people goes up day by day, has occurred various senescence disease thus, and wherein senile disease is the particularly severe of senile dementia performance.At present, the pathogenesis of senile dementia is still indefinite, is amyloid beta cascade hypothesis about the pathogenetic main flow theory of senile dementia.This hypothesis thinks that the abnormal degraded of amyloid beta sample precursor (APP) generates excessive aβ protein, and in brain the core of formation of deposits senile plaque, it can activate microglia, cause inflammation reaction, lesion wire plastochondria causes energy metabolism impairment, generate polyoxy freely, and cause the oxidative stress of body to damage, active cell apoptosis pathway.Senile dementia is the lethal neurodegenerative diseases of a kind of Progressive symmetric erythrokeratodermia development, clinical manifestation is the decline gradually of decrease of cognitive function, mental symptom and behavior disorder, activity of daily living, bring great inconvenience to the life of patients of senile dementia, serious threat old people's is healthy.
At present, treatment senile dementia mainly adopts western medicine, and the key agents for the treatment of is tacrine, donepezil, this bright etc. of profit, mainly by acetylcholine esterase inhibition, increases the content of acetylcholine in brain, promotes neuronic recovery; Aspirin is the effect that treatment inflammation reaches treatment senile dementia; The irritability glutamate receptor antagonists such as memantine, Cell protection from the attack of excitatory transmitter cytotoxic effect, thus reaches the object for the treatment of.Said medicine has certain effect in treatment senile dementia, but, these drug side effectes are obvious, therapeutic effect is difficult to continue, need long-term prescription, recurrent is high, cannot meet the demand of modern society, therefore, the medicine finding a kind of novel effective treatment senile dementia is the difficult problem that contemporary society needs solution badly.
Summary of the invention
The technical problem to be solved in the present invention is to provide the purposes of a kind of Chinese medicine preparation in preparation treatment senile dementia, disclose a kind of Chinese medicine senile dementia being had to better therapeutic effect, and use modern pharmaceutical technology that this Chinese medicine is made the required finished product preparation of modern clinic.
In order to solve the problems of the technologies described above, the technical scheme that inventor deals with problems is, according to the feature of modern pharmaceutical technology and tcm clinical practice experience for many years, and in senile dementia years of researches, meticulous compatibility medical material, repeatedly adjusted, increased and decreased deal and the kind of crude drug by practice, the Chinese prescription that final invention one is brand-new, this Chinese prescription is (with parts by weight):
Radix Astragali 15-28 part, Poria 8-18 part, Bulbus Fritillariae Cirrhosae 14-24 part, Rhizoma Corydalis 6-16 part, Fructus Foeniculi 5-15 part, Radix Platycodonis 7-17 part, Fructus Aurantii Immaturus 3-9 part, Cortex Mori 7-19 part, Caulis Bambusae In Taenia 8-18 part, Carapax Trionycis 10-20 part, Radix Rehmanniae Preparata 9-19 part, Radix Asparagi 6-16 part, Rhizoma Anemarrhenae 2-10 part, Radix Aucklandiae 4-12 part, Cortex Magnoliae Officinalis 13-26 part, Ramulus Cinnamomi 8-18 part, Fructus Amomi 8-20 part, Radix Gentianae Macrophyllae 6-12 part, Radix Glycyrrhizae 8-18 part.
1 proportioning raw materials optimizing therapeutic effect best in prescription quantitative range is:
The Radix Astragali 20 parts, 12 parts, Poria, Bulbus Fritillariae Cirrhosae 18 parts, Rhizoma Corydalis 10 parts, 7 parts, Fructus Foeniculi, Radix Platycodonis 11 parts, Fructus Aurantii Immaturus 6 parts, Cortex Mori 14 parts, Caulis Bambusae In Taenia 12 parts, Carapax Trionycis 15 parts, Radix Rehmanniae Preparata 15 parts, Radix Asparagi 10 parts, the Rhizoma Anemarrhenae 6 parts, the Radix Aucklandiae 7 parts, Cortex Magnoliae Officinalis 17 parts, Ramulus Cinnamomi 12 parts, Fructus Amomi 12 parts, Radix Gentianae Macrophyllae 8 parts, 10 parts, Radix Glycyrrhizae.
The technique above-mentioned Chinese prescription being made preparation is following steps:
(1), each taste Chinese crude drug is taken by Chinese prescription of the present invention;
(2), by the Radix Astragali, Bulbus Fritillariae Cirrhosae, Fructus Aurantii Immaturus, Carapax Trionycis, Radix Rehmanniae Preparata, Radix Asparagi, Fructus Amomi, pulverize respectively, the concentration adding 10 times of weight after mixing is 75% ethanol, soak 12 hours, backflow decocts, and extracts 2 times, each 2 hours, filter, retain filtering residue, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be the concentrated solution of 1.25, for subsequent use;
(3), Poria, Rhizoma Corydalis, Fructus Foeniculi, Radix Platycodonis, Cortex Mori, the Rhizoma Anemarrhenae, the Radix Aucklandiae, Cortex Magnoliae Officinalis, Ramulus Cinnamomi, Radix Gentianae Macrophyllae, Radix Glycyrrhizae are pulverized respectively, with the purified water adding 8 times of weight after the filtering residue mixing of step (2), backflow decoction three times, each 1 hour, filter, merging filtrate, being concentrated into 55 DEG C of relative densities is the concentrated solution of 1.25, for subsequent use;
(4), by concentrated solution obtained in step (2) and (3) merge, add Caulis Bambusae In Taenia, mix homogeneously, continuing to be evaporated to 55 DEG C of relative densities is the thick paste of 1.35, is Chinese medical concrete;
(5), add suitable adjuvant, utilize modern general Chinese medicine preparation technology, step (4) gained Chinese medical concrete is made the Chinese medicine finished product preparation of clinical needs, as dosage forms such as tablet, pill, granule, capsule, oral liquid, powder or syrups.
The character feature of Chinese medicine preparation of the present invention Chinese crude drug used:
The Radix Astragali: this product is the dry root of leguminous plant Radix Astagali or Radix Astragali.Sweet in the mouth, warm in nature; Return lung, spleen channel; Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation, blood vessel dilating, anticoagulant, reduces blood viscosity.
Poria: this product is the dry sclerotia of On Polyporaceae Poria.Sweet in the mouth, light, property is put down; GUIXIN, spleen, kidney channel; Eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming, have antioxidation, anti-aging, increases immunity.
Bulbus Fritillariae Cirrhosae: this product is the dry bulb of liliaceous plant Bulbus Fritillariae Cirrhosae, Fritillaria unibracteata, Gansu Bulbus Fritillariae Uninbracteatae or Bulbus Fritillariae cirrhosae.Bitter in the mouth, sweet, cold nature; Return lung, heart channel; Clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.
Rhizoma Corydalis: this product is the dry tuber of papaveraceae plant corydalis.Acrid in the mouth, hardship, warm in nature; Return liver, spleen channel; Invigorate blood circulation, promoting the circulation of QI, pain relieving.
Fructus Foeniculi: be the fruit of samphire Fructus Foeniculi.Acrid in the mouth, warm in nature; Enter kidney, bladder, stomach warp; Warming kidney for dispelling cold, regulating the stomach to normalize QI.
Radix Platycodonis: this product is the dry root of Campanulaceae Radix Platycodonis.Bitter in the mouth, pungent, property is put down; Return lung meridian; Lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.
Fructus Aurantii Immaturus: this product is the dry young fruit of rutaceae Citrus aurantium Linn. and variety or Fructus Citri sinensis.Bitter in the mouth, pungent, sour, warm in nature; Return spleen, stomach warp; Dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm.
Cortex Mori: this product is the dry root bark of moraceae plants Mulberry.Sweet in the mouth, cold in nature; Return lung meridian; Eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.
Caulis Bambusae In Taenia: this product is the dry intermediate layer of stem stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.Sweet in the mouth, cold nature; Attach to the lung and stomach meridians; Removing heat-phlegm, relieves restlessness and prevents vomiting.
Carapax Trionycis: this product is the carapace of Trionychidae animal Trionyx sinensis Wiegmann.Salty in the mouth, cold nature; Return liver, kidney channel; Nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, brings down a fever except steaming.
Radix Rehmanniae Preparata: this product is the Preparation process product of Radix Rehmanniae.Sweet in the mouth, slightly warm in nature; Return liver, kidney channel; Nourishing YIN and supplementing blood, beneficial essence fills out marrow.
Radix Asparagi: this product is the dried root of liliaceous plant Radix Asparagi.Sweet in the mouth, hardship, cold in nature; Return lung, kidney channel; Nourishing YIN to relieve dryness, lung heat clearing is promoted the production of body fluid.
The Rhizoma Anemarrhenae: this product is the dry rhizome of the liliaceous plant Rhizoma Anemarrhenae.Bitter in the mouth, sweet, cold in nature; Return lung, stomach, kidney channel; Clearing away heat-fire, promotes the production of body fluid and moisturizes.
The Radix Aucklandiae: this product is the dry root of the feverfew Radix Aucklandiae.Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, large intestine, three burnt, gallbladder meridians; Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.
Cortex Magnoliae Officinalis: this product is the dry dried bark of Magnoliacea plant Cortex Magnoliae Officinalis or magnolia officinalis rehd.et wils.var.biloba rehd.et wils., root bark and branch skin.Bitter in the mouth, pungent, warm in nature; Return spleen, stomach, lung, large intestine channel; Dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.
Ramulus Cinnamomi: this product is the dry twig of canella Cortex Cinnamomi.Acrid in the mouth, sweet, warm in nature; GUIXIN, lung, urinary bladder channel; Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.
Fructus Amomi: this product is the dry mature fruit of zingiberaceous plant Fructus Amomi, green shell sand or SEMEN AMOMI LONGILIGULA.Acrid in the mouth, warm in nature; Return spleen, stomach, kidney channel; Removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.
Radix Gentianae Macrophyllae: this product is the dry root of gentianaceae plant Radix Gentianae Macrophyllae, gentiana straminea maxim, gentiana crassicaulis Duthie or Gentiana dahurica.Acrid in the mouth, hardship, property is put down; Return stomach, liver, gallbladder meridian; Wind-damp dispelling, clearing away damp-heat, stopping numbness pain.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention:
Chinese prescription of the present invention is for monarch drug with Poria, Bulbus Fritillariae Cirrhosae, Carapax Trionycis, the Radix Astragali, Cortex Magnoliae Officinalis, there is immunostimulant and immunoregulatory effect, blood vessel dilating, anticoagulant, reduce blood viscosity, improve the perfusion flow of blood circulation and brain, nourishing YIN for suppressing the hyperactive YANG, lung heat clearing are promoted the production of body fluid, dampness expectorant; With Radix Asparagi, Rhizoma Corydalis, Radix Rehmanniae Preparata, Caulis Bambusae In Taenia, Radix Platycodonis for ministerial drug, invigorating QI to consolidate the body surface resistance, promoting the circulation of QI of invigorating blood circulation, nourishing YIN and supplementing blood, there is antioxidation, anti-aging; With Cortex Mori, Fructus Aurantii Immaturus, Fructus Amomi, Ramulus Cinnamomi for adjuvant drug, inducing diuresis to remove edema, removing dampness warming the spleen, promoting the flow of QI-blood by warming the meridian; With Fructus Foeniculi, the Rhizoma Anemarrhenae, the Radix Aucklandiae, Radix Gentianae Macrophyllae for making medicine, warming kidney for dispelling cold, promote the production of body fluid moisturize, promoting the circulation of QI to relieve pain, dispel the wind wet clearly; With Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, all medicines are arranged in pairs or groups, synergism, jointly reach and there is antioxidation, anti-aging, there is immunostimulant and immunoregulatory effect, blood vessel dilating, anticoagulant, reduce blood viscosity, improve the effects such as the perfusion flow of blood circulation and brain, have very significant therapeutic effect to senile dementia.
Compared with prior art, Chinese medicine preparation of the present invention is in treatment senile dementia, there is instant effect, effective, treating both the principal and secondary aspects of a disease, medical treatment combination, therapeutic effect continue, there is no toxic and side effects, there is effect of conditioning patient body, improve the immunologic function of patient, and its preparation technology is simple and easy to do, preparation efficacy stability, universality are good, be easy to apply.
Detailed description of the invention
embodiment 1,the capsule preparation of Chinese medicine preparation of the present invention
(1), Radix Astragali 15kg, Poria 8kg, Bulbus Fritillariae Cirrhosae 14kg, Rhizoma Corydalis 6kg, Fructus Foeniculi 5kg, Radix Platycodonis 7kg, Fructus Aurantii Immaturus 3kg, Cortex Mori 7kg, Caulis Bambusae In Taenia 8kg, Carapax Trionycis 20kg, Radix Rehmanniae Preparata 19kg, Radix Asparagi 16kg, Rhizoma Anemarrhenae 10kg, Radix Aucklandiae 12kg, Cortex Magnoliae Officinalis 26kg, Ramulus Cinnamomi 18kg, Fructus Amomi 20kg, Radix Gentianae Macrophyllae 12kg, Radix Glycyrrhizae 18kg is taken by Chinese prescription of the present invention;
(2), by the Radix Astragali, Bulbus Fritillariae Cirrhosae, Fructus Aurantii Immaturus, Carapax Trionycis, Radix Rehmanniae Preparata, Radix Asparagi, Fructus Amomi, pulverize respectively, the concentration adding 10 times of weight after mixing is 75% ethanol, soak 12 hours, backflow decocts, and extracts 2 times, each 2 hours, filter, retain filtering residue, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be the concentrated solution of 1.25, for subsequent use;
(3), Poria, Rhizoma Corydalis, Fructus Foeniculi, Radix Platycodonis, Cortex Mori, the Rhizoma Anemarrhenae, the Radix Aucklandiae, Cortex Magnoliae Officinalis, Ramulus Cinnamomi, Radix Gentianae Macrophyllae, Radix Glycyrrhizae are pulverized respectively, with the purified water adding 8 times of weight after the filtering residue mixing of step (2), backflow decoction three times, each 1 hour, filter, merging filtrate, being concentrated into 55 DEG C of relative densities is the concentrated solution of 1.25, for subsequent use;
(4), by concentrated solution obtained in step (2) and (3) merge, add Caulis Bambusae In Taenia, mix homogeneously, continuing to be evaporated to 55 DEG C of relative densities is the thick paste of 1.35, is Chinese medical concrete;
(5), add suitable adjuvant, make capsule.
embodiment 2,the capsule preparation of Chinese medicine preparation of the present invention
(1), Radix Astragali 20kg, Poria 12kg, Bulbus Fritillariae Cirrhosae 18kg, Rhizoma Corydalis 10kg, Fructus Foeniculi 7kg, Radix Platycodonis 11kg, Fructus Aurantii Immaturus 6kg, Cortex Mori 14kg, Caulis Bambusae In Taenia 12kg, Carapax Trionycis 15kg, Radix Rehmanniae Preparata 15kg, Radix Asparagi 10kg, Rhizoma Anemarrhenae 6kg, Radix Aucklandiae 7kg, Cortex Magnoliae Officinalis 17kg, Ramulus Cinnamomi 12kg, Fructus Amomi 12kg, Radix Gentianae Macrophyllae 8kg, Radix Glycyrrhizae 10kg is taken by Chinese prescription of the present invention;
(2), by the Radix Astragali, Bulbus Fritillariae Cirrhosae, Fructus Aurantii Immaturus, Carapax Trionycis, Radix Rehmanniae Preparata, Radix Asparagi, Fructus Amomi, pulverize respectively, the concentration adding 10 times of weight after mixing is 75% ethanol, soak 12 hours, backflow decocts, and extracts 2 times, each 2 hours, filter, retain filtering residue, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be the concentrated solution of 1.25, for subsequent use;
(3), Poria, Rhizoma Corydalis, Fructus Foeniculi, Radix Platycodonis, Cortex Mori, the Rhizoma Anemarrhenae, the Radix Aucklandiae, Cortex Magnoliae Officinalis, Ramulus Cinnamomi, Radix Gentianae Macrophyllae, Radix Glycyrrhizae are pulverized respectively, with the purified water adding 8 times of weight after the filtering residue mixing of step (2), backflow decoction three times, each 1 hour, filter, merging filtrate, being concentrated into 55 DEG C of relative densities is the concentrated solution of 1.25, for subsequent use;
(4), by concentrated solution obtained in step (2) and (3) merge, add Caulis Bambusae In Taenia, mix homogeneously, continuing to be evaporated to 55 DEG C of relative densities is the thick paste of 1.35, is Chinese medical concrete;
(5), add suitable adjuvant, make capsule.
embodiment 3,the granule preparation of Chinese medicine preparation of the present invention
(1), Radix Astragali 28kg, Poria 18kg, Bulbus Fritillariae Cirrhosae 24kg, Rhizoma Corydalis 16kg, Fructus Foeniculi 15kg, Radix Platycodonis 17kg, Fructus Aurantii Immaturus 9kg, Cortex Mori 19kg, Caulis Bambusae In Taenia 18kg, Carapax Trionycis 10kg, Radix Rehmanniae Preparata 9kg, Radix Asparagi 6kg, Rhizoma Anemarrhenae 2kg, Radix Aucklandiae 4kg, Cortex Magnoliae Officinalis 13kg, Ramulus Cinnamomi 8kg, Fructus Amomi 8kg, Radix Gentianae Macrophyllae 6kg, Radix Glycyrrhizae 8kg is taken by Chinese prescription of the present invention;
(2), by the Radix Astragali, Bulbus Fritillariae Cirrhosae, Fructus Aurantii Immaturus, Carapax Trionycis, Radix Rehmanniae Preparata, Radix Asparagi, Fructus Amomi, pulverize respectively, the concentration adding 10 times of weight after mixing is 75% ethanol, soak 12 hours, backflow decocts, and extracts 2 times, each 2 hours, filter, retain filtering residue, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be the concentrated solution of 1.25, for subsequent use;
(3), Poria, Rhizoma Corydalis, Fructus Foeniculi, Radix Platycodonis, Cortex Mori, the Rhizoma Anemarrhenae, the Radix Aucklandiae, Cortex Magnoliae Officinalis, Ramulus Cinnamomi, Radix Gentianae Macrophyllae, Radix Glycyrrhizae are pulverized respectively, with the purified water adding 8 times of weight after the filtering residue mixing of step (2), backflow decoction three times, each 1 hour, filter, merging filtrate, being concentrated into 55 DEG C of relative densities is the concentrated solution of 1.25, for subsequent use;
(4), by concentrated solution obtained in step (2) and (3) merge, add Caulis Bambusae In Taenia, mix homogeneously, continuing to be evaporated to 55 DEG C of relative densities is the thick paste of 1.35, is Chinese medical concrete;
(5), add suitable adjuvant, make granule.
embodiment 4,the tablet preparation of Chinese medicine preparation of the present invention
(1), Radix Astragali 20kg, Poria 16kg, Bulbus Fritillariae Cirrhosae 23kg, Rhizoma Corydalis 11kg, Fructus Foeniculi 10kg, Radix Platycodonis 13kg, Fructus Aurantii Immaturus 6kg, Cortex Mori 12kg, Caulis Bambusae In Taenia 16kg, Carapax Trionycis 15kg, Radix Rehmanniae Preparata 10kg, Radix Asparagi 7kg, Rhizoma Anemarrhenae 5kg, Radix Aucklandiae 4kg, Cortex Magnoliae Officinalis 16kg, Ramulus Cinnamomi 10kg, Fructus Amomi 8kg, Radix Gentianae Macrophyllae 10kg, Radix Glycyrrhizae 15kg is taken by Chinese prescription of the present invention;
(2), by the Radix Astragali, Bulbus Fritillariae Cirrhosae, Fructus Aurantii Immaturus, Carapax Trionycis, Radix Rehmanniae Preparata, Radix Asparagi, Fructus Amomi, pulverize respectively, the concentration adding 10 times of weight after mixing is 75% ethanol, soak 12 hours, backflow decocts, and extracts 2 times, each 2 hours, filter, retain filtering residue, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be the concentrated solution of 1.25, for subsequent use;
(3), Poria, Rhizoma Corydalis, Fructus Foeniculi, Radix Platycodonis, Cortex Mori, the Rhizoma Anemarrhenae, the Radix Aucklandiae, Cortex Magnoliae Officinalis, Ramulus Cinnamomi, Radix Gentianae Macrophyllae, Radix Glycyrrhizae are pulverized respectively, with the purified water adding 8 times of weight after the filtering residue mixing of step (2), backflow decoction three times, each 1 hour, filter, merging filtrate, being concentrated into 55 DEG C of relative densities is the concentrated solution of 1.25, for subsequent use;
(4), by concentrated solution obtained in step (2) and (3) merge, add Caulis Bambusae In Taenia, mix homogeneously, continuing to be evaporated to 55 DEG C of relative densities is the thick paste of 1.35, is Chinese medical concrete;
(5), add suitable adjuvant, make tablet.
embodiment 5,the syrup preparation of Chinese medicine preparation of the present invention
(1), Radix Astragali 24kg, Poria 16kg, Bulbus Fritillariae Cirrhosae 16kg, Rhizoma Corydalis 10kg, Fructus Foeniculi 12kg, Radix Platycodonis 10kg, Fructus Aurantii Immaturus 5kg, Cortex Mori 8kg, Caulis Bambusae In Taenia 14kg, Carapax Trionycis 13kg, Radix Rehmanniae Preparata 12kg, Radix Asparagi 7kg, Rhizoma Anemarrhenae 6kg, Radix Aucklandiae 6kg, Cortex Magnoliae Officinalis 13kg, Ramulus Cinnamomi 10kg, Fructus Amomi 8kg, Radix Gentianae Macrophyllae 11kg, Radix Glycyrrhizae 10kg is taken by Chinese prescription of the present invention;
(2), by the Radix Astragali, Bulbus Fritillariae Cirrhosae, Fructus Aurantii Immaturus, Carapax Trionycis, Radix Rehmanniae Preparata, Radix Asparagi, Fructus Amomi, pulverize respectively, the concentration adding 10 times of weight after mixing is 75% ethanol, soak 12 hours, backflow decocts, and extracts 2 times, each 2 hours, filter, retain filtering residue, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be the concentrated solution of 1.25, for subsequent use;
(3), Poria, Rhizoma Corydalis, Fructus Foeniculi, Radix Platycodonis, Cortex Mori, the Rhizoma Anemarrhenae, the Radix Aucklandiae, Cortex Magnoliae Officinalis, Ramulus Cinnamomi, Radix Gentianae Macrophyllae, Radix Glycyrrhizae are pulverized respectively, with the purified water adding 8 times of weight after the filtering residue mixing of step (2), backflow decoction three times, each 1 hour, filter, merging filtrate, being concentrated into 55 DEG C of relative densities is the concentrated solution of 1.25, for subsequent use;
(4), by concentrated solution obtained in step (2) and (3) merge, add Caulis Bambusae In Taenia, mix homogeneously, continuing to be evaporated to 55 DEG C of relative densities is the thick paste of 1.35, is Chinese medical concrete;
(5), add suitable adjuvant, make syrup.
embodiment 6,chinese medicine preparation of the present invention is to A β
1-42the therapeutic test of caused rat senile dementia model
1 materials and methods
1.1 test material
Experimental animal is male SD rat, and in Mus 8-9 in age week, body weight 250-280 g, is provided by The 2nd Army Medical College Experimental Animal Center.A β 25-35 purchased from American Sigma company, Morris water maze is purchased from Shanghai Ji Liang company.
The foundation of 1.2 rat senile dementia models and evaluation
1.2.1 intracerebral ventricle injection A β
1-42the preparation of solution: by A β
1-42be dissolved in physiological saline solution, make A β concentration be 10 mmol/L, put in 37 DEG C of calorstats to hatch and carry out aging in 3 days.
1.2.2 the making of animal model: raise under standard environment, is divided into 2 groups at random: matched group and model group, often organizes 12.2 groups of there was no significant differences on Mus age and body weight.Animal gives after adaptability feeds 1 week, by rat with 2% pentobarbital sodium intraperitoneal anesthesia (40 ~ 50 mg/kg weight), be fixed on stereo brain orienting instrument, cut off head hair, skin is cut after iodine tincture disinfection, select right side tricorn for injection target area with reference to " rat brain stereotaxic atlas ", in bregma 1.0 mm backward, center line is other opens 1.6 mm places, bore with three edged needle and open skull, expose cerebral dura mater, use microsyringe again with the speed of 12 μm/s from vertical inserting needle 4.0 mm in brain surface, 10 mmol/L A β 1-42 solution 5 μ l are slowly injected, slowly pin is removed after let the acupuncture needle remain at a certain point 2 min, sew up the incision.Matched group injects equal-volume physiological saline solution.
1.2.3 Morris water maze behavioristics measures: 2 groups of rats started to carry out the test of Morris water maze respectively at postoperative 10th day.Test program is orientation navigation test: last 5 days, first 2 days is the training adaptation phase, and latter 3 days record achievements, if rat finds platform in 1 min, record its actual escape latency; If find platform not yet in 1 min, then drawn upper mounting plate by experimenter and stop 20 S, escape latency is recorded as 1 min.
1.2.4 the evaluation of animal model
As can be seen from the above table, escape latency matched group from the 1st day of test data sheet of model group just obviously extends (P < 0.05 or P < 0.01), and escape latency between model group 3 days and escape latency no significant difference between matched group 3 days, show that the senile dementia type adopting the method to set up is reliably accurate, may be used for the evaluating drug effect of curing senile dementia medicine.
2 animal models and grouping administration
Be set to model group, low dose group, middle dosage group and high dose group according to above-mentioned modeling method modeling, and matched group is set, often organize 11, raise under standard environment.Each group of administering mode is as described below:
Matched group: gavage gives the normal saline of same volume;
Model group: gavage gives the normal saline of same volume;
Low dose group: gavage gives capsule 50mg/kg/d prepared by embodiment 2;
Middle dosage group: gavage gives capsule 100mg/kg/d prepared by embodiment 2;
High dose group: gavage gives capsule 150mg/kg/d prepared by embodiment 2.
Above-mentioned administration group is respectively at administration afterwards in 10 days after modeling, within 11st day, be recorded as the 1st day, every day is administered once, observe drinking water for animals and diet situation every day, respectively at administration the 1st day, administration the 5th day, administration the 10th day, administration the 15th day, administration measures the escape latency of rat for 20 days with Morris water maze behavioristics assay method.Rat is put to death after last mensuration completes.Ge Zu treated rats in Morris water maze performance behavioristics measurement result is as shown in the table.
Table 1 Chinese medicine preparation of the present invention is to A β
1-42the therapeutic effect (escape latency, unit S) of caused rat senile dementia model
Compared with model group, * P < 0.05, * * P < 0.01;
As can be seen from Table 1: each administration group escape latency there was no significant difference of the 1st day, but along with the prolongation of administration time, the escape latency difference of each administration group rat strengthens, wherein of the present invention low, in and high dose group all there is positive therapeutical effect.At the 15th day and 20 days, of the present invention low, in compared with model group, there is significant difference with the rat escape latency of high dose group, all significantly shorten the escape latency of rat, it was at the 20th day, and high dose group has pole significant difference compared with model group.Prove that pharmaceutical composition of the present invention is to A β
1-42caused rat senile dementia disease model has significant therapeutic effect.
embodiment 7,chinese medicine preparation of the present invention is to the clinical trial of senile dementia
1, experimenter's data:
Experimenter, all from certain health of older persons hospital of city, is the patients of senile dementia that this hospital accepts for medical treatment, therefrom selects applicable clinical trial patient 120, in age 50-80 year, all patients are divided into 2 groups, are numbered A, B group respectively, often organize 60, the mean age is respectively 66.7.
2, trial drug
Trial drug is capsule prepared by the embodiment of the present invention 2.
3, test method
Capsule prepared by the oral embodiment 2 of A, B two group difference, 15g/ time, every day 3 times 30 days is a course for the treatment of, treats 4 courses for the treatment of continuously, checks patient condition after 4 courses for the treatment of.
4, test evaluation standard
With reference to " diagnosis of Research of Senile Dementia Treated, differentiation of symptoms and signs for classification of syndrome and efficacy assessment standard " and " new Chinese medicine treats dull-witted guideline of clinical investigations "
(1) effective: senile dementia transference cure is clearly better, the basic animation recovering normal person.
(2) effective: senile dementia symptom takes a turn for the better to some extent, the functions such as memory, judgement and language increase.
(3) invalid: senile dementia symptom does not change.
5, result of the test
After all case tests, statistical analysis calculating is carried out to result, as shown in table 2:
Table 2 result of the test statistical analysis table
| Group | Case load | Effective (rate) | Effectively (rate) | Invalid (rate) | Total effective rate |
| A group | 60 | 47（78.3%） | 9（15%） | 4（6.7%） | 93.3% |
| B group | 60 | 46（76.7%） | 11（18.3%） | 3（5%） | 95% |
Chinese medicine preparation A, B of the present invention two groups of groups are to the effect for the treatment of patients of senile dementia, and the average obvious effective rate of 2 groups is 77.5%, and the symptom of senile dementia has obvious rear turn, and basic recovery is lived normally; Total effective rate is 94.15%, takes a turn for the better to some extent to senile dementia symptom, slows down the decrease speed of memory, identification, language function, alleviates senile dementia to the misery of patient.Chinese medicine preparation of the present invention has good therapeutic effect to senile dementia, and this Chinese medicine preparation is pure Chinese medicinal preparation, can not have side effects, regulate function of human body in addition to human body, improves the effect of immunity, is conducive to the promotion and application of this Chinese medicine preparation.
Claims (4)
1. the purposes of Chinese medicine preparation in preparation treatment senile dementia, it is characterized in that, described Chinese medicine preparation prescription is:
Radix Astragali 15-28 part, Poria 8-18 part, Bulbus Fritillariae Cirrhosae 14-24 part, Rhizoma Corydalis 6-16 part, Fructus Foeniculi 5-15 part, Radix Platycodonis 7-17 part, Fructus Aurantii Immaturus 3-9 part, Cortex Mori 7-19 part, Caulis Bambusae In Taenia 8-18 part, Carapax Trionycis 10-20 part, Radix Rehmanniae Preparata 9-19 part, Radix Asparagi 6-16 part, Rhizoma Anemarrhenae 2-10 part, Radix Aucklandiae 4-12 part, Cortex Magnoliae Officinalis 13-26 part, Ramulus Cinnamomi 8-18 part, Fructus Amomi 8-20 part, Radix Gentianae Macrophyllae 6-12 part, Radix Glycyrrhizae 8-18 part.
2. purposes according to claim 1, is characterized in that, described Chinese medicine preparation prescription is:
The Radix Astragali 20 parts, 12 parts, Poria, Bulbus Fritillariae Cirrhosae 18 parts, Rhizoma Corydalis 10 parts, 7 parts, Fructus Foeniculi, Radix Platycodonis 11 parts, Fructus Aurantii Immaturus 6 parts, Cortex Mori 14 parts, Caulis Bambusae In Taenia 12 parts, Carapax Trionycis 15 parts, Radix Rehmanniae Preparata 15 parts, Radix Asparagi 10 parts, the Rhizoma Anemarrhenae 6 parts, the Radix Aucklandiae 7 parts, Cortex Magnoliae Officinalis 17 parts, Ramulus Cinnamomi 12 parts, Fructus Amomi 12 parts, Radix Gentianae Macrophyllae 8 parts, 10 parts, Radix Glycyrrhizae.
3. purposes according to claim 1, is characterized in that, the preparation technology of described Chinese medicine preparation comprises the following steps:
Step (1), take each taste Chinese crude drug by Chinese prescription of the present invention;
Step (2), by the Radix Astragali, Bulbus Fritillariae Cirrhosae, Fructus Aurantii Immaturus, Carapax Trionycis, Radix Rehmanniae Preparata, Radix Asparagi, Fructus Amomi, pulverize respectively, the concentration adding 10 times of weight after mixing is 75% ethanol, soak 12 hours, backflow decocts, and extracts 2 times, each 2 hours, filter, retain filtering residue, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be the concentrated solution of 1.25, for subsequent use;
Step (3), Poria, Rhizoma Corydalis, Fructus Foeniculi, Radix Platycodonis, Cortex Mori, the Rhizoma Anemarrhenae, the Radix Aucklandiae, Cortex Magnoliae Officinalis, Ramulus Cinnamomi, Radix Gentianae Macrophyllae, Radix Glycyrrhizae to be pulverized respectively, with the purified water adding 8 times of weight after the filtering residue mixing of step (2), backflow decoction three times, each 1 hour, filter, merging filtrate, being concentrated into 55 DEG C of relative densities is the concentrated solution of 1.25, for subsequent use;
Step (4), the concentrated solution merging will obtained in step (2) and (3), add Caulis Bambusae In Taenia, mix homogeneously, continuing to be evaporated to 55 DEG C of relative densities is the thick paste of 1.35, is Chinese medical concrete;
Step (5), add suitable adjuvant, utilize modern general Chinese medicine preparation technology, step (4) gained Chinese medical concrete is made the Chinese medicine finished product preparation of clinical needs.
4. purposes according to claim 1, is characterized in that, described Chinese medicine preparation makes tablet, pill, granule, capsule, oral liquid, powder or syrup.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105497365A (en) * | 2016-01-22 | 2016-04-20 | 顾志情 | Traditional Chinese medicinal composition for treating alzheimer disease, as well as preparation method and application thereof |
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| JP2007230938A (en) * | 2006-03-02 | 2007-09-13 | Toyama Univ | Preventing or improving agent of alzheimer type memory disorder |
| CN103816462A (en) * | 2012-11-16 | 2014-05-28 | 丁徽 | Traditional Chinese medicine for treating hemiplegia |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007230938A (en) * | 2006-03-02 | 2007-09-13 | Toyama Univ | Preventing or improving agent of alzheimer type memory disorder |
| CN103816462A (en) * | 2012-11-16 | 2014-05-28 | 丁徽 | Traditional Chinese medicine for treating hemiplegia |
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| 高云等: "老年呆病", 《山东中医杂志》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105497365A (en) * | 2016-01-22 | 2016-04-20 | 顾志情 | Traditional Chinese medicinal composition for treating alzheimer disease, as well as preparation method and application thereof |
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