CN109091633A - It is a kind of for the composition and preparation method of infantile respiratory tract infection repeatedly and application - Google Patents
It is a kind of for the composition and preparation method of infantile respiratory tract infection repeatedly and application Download PDFInfo
- Publication number
- CN109091633A CN109091633A CN201811249802.0A CN201811249802A CN109091633A CN 109091633 A CN109091633 A CN 109091633A CN 201811249802 A CN201811249802 A CN 201811249802A CN 109091633 A CN109091633 A CN 109091633A
- Authority
- CN
- China
- Prior art keywords
- parts
- respiratory tract
- composition
- tract infection
- ginseng
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010057190 Respiratory tract infections Diseases 0.000 title claims abstract description 40
- 239000000203 mixture Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- 235000008434 ginseng Nutrition 0.000 claims abstract description 32
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 31
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 31
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims abstract description 29
- 235000017491 Bambusa tulda Nutrition 0.000 claims abstract description 29
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims abstract description 29
- 239000011425 bamboo Substances 0.000 claims abstract description 29
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 27
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 26
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 26
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 26
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 26
- 210000003038 endothelium Anatomy 0.000 claims abstract description 25
- 241000244269 Peucedanum Species 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 17
- 241001330002 Bambuseae Species 0.000 claims description 28
- 239000003814 drug Substances 0.000 claims description 26
- 229940079593 drug Drugs 0.000 claims description 21
- 239000000463 material Substances 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 7
- 238000012856 packing Methods 0.000 claims description 5
- 235000013305 food Nutrition 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 241000208340 Araliaceae Species 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 244000082204 Phyllostachys viridis Species 0.000 abstract 1
- 240000004371 Panax ginseng Species 0.000 description 22
- 210000000952 spleen Anatomy 0.000 description 22
- 206010011224 Cough Diseases 0.000 description 19
- 210000004072 lung Anatomy 0.000 description 18
- 230000006870 function Effects 0.000 description 16
- 208000024891 symptom Diseases 0.000 description 12
- 206010062717 Increased upper airway secretion Diseases 0.000 description 11
- 208000026435 phlegm Diseases 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 206010036790 Productive cough Diseases 0.000 description 8
- 210000002216 heart Anatomy 0.000 description 8
- 208000015181 infectious disease Diseases 0.000 description 8
- 210000003734 kidney Anatomy 0.000 description 8
- 210000002784 stomach Anatomy 0.000 description 8
- 206010037660 Pyrexia Diseases 0.000 description 7
- 210000002345 respiratory system Anatomy 0.000 description 7
- 206010013911 Dysgeusia Diseases 0.000 description 6
- 230000007812 deficiency Effects 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 6
- 235000019634 flavors Nutrition 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 230000007935 neutral effect Effects 0.000 description 6
- 208000024794 sputum Diseases 0.000 description 6
- 210000003802 sputum Anatomy 0.000 description 6
- 206010024971 Lower respiratory tract infections Diseases 0.000 description 5
- 208000036071 Rhinorrhea Diseases 0.000 description 5
- 206010039101 Rhinorrhoea Diseases 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000012141 concentrate Substances 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 238000005728 strengthening Methods 0.000 description 4
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 3
- 241000287828 Gallus gallus Species 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000002612 cardiopulmonary effect Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 201000006549 dyspepsia Diseases 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 229940069338 potassium sorbate Drugs 0.000 description 3
- 235000010241 potassium sorbate Nutrition 0.000 description 3
- 239000004302 potassium sorbate Substances 0.000 description 3
- 235000021251 pulses Nutrition 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000227129 Aconitum Species 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000758794 Asarum Species 0.000 description 2
- 201000004813 Bronchopneumonia Diseases 0.000 description 2
- 241001672694 Citrus reticulata Species 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 244000303040 Glycyrrhiza glabra Species 0.000 description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 2
- 241001522129 Pinellia Species 0.000 description 2
- 244000197580 Poria cocos Species 0.000 description 2
- 235000008599 Poria cocos Nutrition 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 238000009412 basement excavation Methods 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 210000000621 bronchi Anatomy 0.000 description 2
- 229940124630 bronchodilator Drugs 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 239000002934 diuretic Substances 0.000 description 2
- 229940030606 diuretics Drugs 0.000 description 2
- 238000003306 harvesting Methods 0.000 description 2
- LELOWRISYMNNSU-UHFFFAOYSA-N hydrogen cyanide Chemical compound N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 description 2
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 229910052957 realgar Inorganic materials 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 210000003932 urinary bladder Anatomy 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- XUCIJNAGGSZNQT-JHSLDZJXSA-N (R)-amygdalin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O[C@@H](C#N)C=2C=CC=CC=2)O1 XUCIJNAGGSZNQT-JHSLDZJXSA-N 0.000 description 1
- XFSBVAOIAHNAPC-XTHSEXKGSA-N 16-Ethyl-1alpha,6alpha,19beta-trimethoxy-4-(methoxymethyl)-aconitane-3alpha,8,10alpha,11,18alpha-pentol, 8-acetate 10-benzoate Chemical compound O([C@H]1[C@]2(O)C[C@H]3[C@@]45C6[C@@H]([C@@]([C@H]31)(OC(C)=O)[C@@H](O)[C@@H]2OC)[C@H](OC)[C@@H]4[C@]([C@@H](C[C@@H]5OC)O)(COC)CN6CC)C(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-XTHSEXKGSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- XFSBVAOIAHNAPC-UHFFFAOYSA-N Aconitin Natural products CCN1CC(C(CC2OC)O)(COC)C3C(OC)C(C(C45)(OC(C)=O)C(O)C6OC)C1C32C4CC6(O)C5OC(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010001497 Agitation Diseases 0.000 description 1
- 241000208173 Apiaceae Species 0.000 description 1
- 206010007027 Calculus urinary Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 241001465251 Ephedra sinica Species 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 241001278898 Glycyrrhiza inflata Species 0.000 description 1
- 240000008917 Glycyrrhiza uralensis Species 0.000 description 1
- 235000000554 Glycyrrhiza uralensis Nutrition 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 244000118681 Iresine herbstii Species 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 241001254606 Peucedanum praeruptorum Species 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 241000544428 Phyllostachys glauca Species 0.000 description 1
- 244000302693 Phyllostachys nuda Species 0.000 description 1
- 235000014322 Phyllostachys nuda Nutrition 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010041497 Spermatorrhoea Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 229940039750 aconitine Drugs 0.000 description 1
- STDXGNLCJACLFY-UHFFFAOYSA-N aconitine Natural products CCN1CC2(COC)C(O)CC(O)C34C5CC6(O)C(OC)C(O)C(OC(=O)C)(C5C6OC(=O)c7ccccc7)C(C(OC)C23)C14 STDXGNLCJACLFY-UHFFFAOYSA-N 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 229940089837 amygdalin Drugs 0.000 description 1
- YZLOSXFCSIDECK-UHFFFAOYSA-N amygdalin Natural products OCC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC(C#N)c3ccccc3 YZLOSXFCSIDECK-UHFFFAOYSA-N 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001088 anti-asthma Effects 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000010231 banlangen Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000001886 ciliary effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229960004126 codeine Drugs 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- YGHHWSRCTPQFFC-UHFFFAOYSA-N eucalyptosin A Natural products OC1C(O)C(O)C(CO)OC1OC1C(OC(C#N)C=2C=CC=CC=2)OC(CO)C(O)C1O YGHHWSRCTPQFFC-UHFFFAOYSA-N 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 201000005630 leukorrhea Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000037306 mature skin Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000008271 nervous system development Effects 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000009711 regulatory function Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 208000008281 urolithiasis Diseases 0.000 description 1
- 206010046901 vaginal discharge Diseases 0.000 description 1
- 230000001457 vasomotor Effects 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of composition for infantile respiratory tract infection repeatedly and preparation method and application, effect is inaccurate in the prior art for solution, the bad problem of safety.The present invention also provides the preparation methods of the composition.Composition of the invention is made: 5-50 parts of ginseng, 10-80 parts of Chinese yam, 10-60 parts of endothelium corneum gigeriae galli, 5-60 parts of dried orange peel, 5-30 parts of radix glycyrrhizae preparata, 5-40 parts of the root of purple-flowered peucedanum, 20-120 parts of bamboo juice of the raw material for including following parts by weight.Prescription science of the present invention, rationally, safety is taken in each component synergistic effect, the common effect for playing treatment infantile respiratory tract infection repeatedly for a long time to proportion.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, and in particular to a kind of composition and system for infantile respiratory tract infection repeatedly
Method and application.
Background technique
Repeated respiratory infections is Pediatric Clinic common disease, and disease incidence is up to 20% or so.Refer to the infection of the upper respiratory tract in 1 year
Or lower respiratory tract infection number is frequent, has been more than a certain range of respiratory tract infection.Different age diagnostic criteria is different, repeatedly
Infant is more than 7 times/year within the infection of the upper respiratory tract 2 years old, and 3~5 years old children is more than 6 times/year, and 6 years old or more children are more than 5 times/
Year;Infant is more than 3 times/year within lower respiratory tract infection 2 years old repeatedly, and 3~5 years old children is more than 2 times/year, and children are super within 6 years old or more
Cross 2 times/year of diagnosable repeated respiratory infections.
There are many reason of causing infantile respiratory tract infection repeatedly.Children are in the growth hair phase, and each allelotaxis is not yet
Maturation, various regulatory functions are still unstable, strong to the neurological susceptibility of disease, and the stress function is low.After the onset of children, fruit sputum is discharged not
It is unobstructed, the recession of inflammation or even sputum can be hindered to become the culture medium of bacterial reproduction in vivo, cause secondary infection, aggravate disease
Feelings.Dyspepsia is pathogenic factor as pathological product, can induce children and send out multiple respiratory tract infection.
In the prior art, have and infantile respiratory tract infection repeatedly is controlled using bronchodilator.But children's bronchus is smooth
Flesh and nervous system development are not mature enough, poor to bronchodilator sensibility, and toxic reaction is strong, especially Western medicine ammonia tea
Alkali, Chinese medicine Chinese ephedra easily cause children irritated, and device is bored, irritability, or even the nervous systems excitability such as twitch increases symptom.
In addition there are anti-using the treatment children such as semen armeniacae amarae, the tuber of pinellia, asarum, rhizoma zingiberis, Aconitum drug, realgar, diuretics
Multiple respiratory tract infection.But semen armeniacae amarae, toxic, amygdalin generates a small amount of hydrogen cyanide after decomposing, and can resist coughing centre and play town
Cough antiasthmatic effect, but sputum is made to be not easy to be discharged.Diuretics such as rhizoma alismatis, umbellate pore furgus, have stronger diuresis, can hurt the saliva of children
Liquid damages healthy tendency.The tuber of pinellia: pungent-warm is dry, therefore children cough should not use long.Asarum: with poison, pharmacological property is more fierce, and consumption hurts healthy tendency.
Rhizoma zingiberis: modern pharmacological studies have shown that the directly excited heart of rhizoma zingiberis energy, has excitation to vasomotor center.Because of children's heart rate
Quickly, as used drug excitement heart, heart rate can be accelerated, lead to the myocardial ischemia even appearance of heart failure.It is monkshood, radix aconiti agrestis, attached
Son contains aconitine ingredient, and poisoning is mainly shown as the symptom of nerve and cardiovascular system.The main component of realgar is three oxygen
Change two arsenic, can lead to cell death, thus causes the function and organic disease of each system of body.Also there is the report using pappy shell
Road, but children are especially sensitive to morphine, and codeine is to inhibit coughing centre and play antitussive effect, and sputum is made to be not easy to be discharged.
In addition, also allergic symptom occur to common Chinese medicine such as Radix Isatidis, radix paeoniae rubra, Poria cocos etc. in Yi Yinqi children, show as complete
Body and local skin play bean cotyledon size erythema, itch, swelling.Closely there is contact Poria cocos to cause the report of allergic bronchial asthma.
Therefore it provides a kind of composition, can be used for infantile respiratory tract infection repeatedly, and definite effect, adverse reaction is small, at
For those skilled in the art's urgent problem to be solved.
Summary of the invention
Technical problem solved by the present invention is providing a kind of composition for infantile respiratory tract infection repeatedly, solve existing
There is effect in technology inaccurate, the bad problem of safety.
The present invention also provides the preparation methods of the composition.
The application that invention further provides the compositions in the drug or food for preparing infantile respiratory tract infection repeatedly.
The technical solution adopted by the invention is as follows:
A kind of composition for infantile respiratory tract infection repeatedly of the present invention, by the raw material including following parts by weight
It is made: 5-50 parts of ginseng, 10-80 parts of Chinese yam, 10-60 parts of endothelium corneum gigeriae galli, 5-60 parts of dried orange peel, 5-30 parts of radix glycyrrhizae preparata, 5-40 parts of the root of purple-flowered peucedanum,
20-120 parts of bamboo juice.
Preferably, by including that the raw material of following parts by weight is made: 8-35 parts of ginseng, 15-65 parts of Chinese yam, endothelium corneum gigeriae galli 15-50
Part, 8-45 parts of dried orange peel, 8-25 parts of radix glycyrrhizae preparata, 8-35 parts of the root of purple-flowered peucedanum, 25-105 parts of bamboo juice.
Preferably, by including that the raw material of following parts by weight is made: 10 parts of ginseng, 20 parts of Chinese yam, 20 parts of endothelium corneum gigeriae galli, dried orange peel 10
Part, 10 parts of radix glycyrrhizae preparata, 10 parts of the root of purple-flowered peucedanum, 30 parts of bamboo juice.
Preferably, by including that the raw material of following parts by weight is made: 30 parts of ginseng, 60 parts of Chinese yam, 40 parts of endothelium corneum gigeriae galli, dried orange peel 40
Part, 20 parts of radix glycyrrhizae preparata, 30 parts of the root of purple-flowered peucedanum, 100 parts of bamboo juice.
Preferably, the dosage of the raw material meet one of following 3 kinds of situations or more than one:
Ginseng/(dried orange peel+root of purple-flowered peucedanum) is 0.3-0.7;
Radix glycyrrhizae preparata/(Chinese yam+bamboo juice) is 0.1-0.3;
(ginseng+endothelium corneum gigeriae galli)/bamboo juice is 0.48-1.5.
Preferably, the dosage of the raw material meet one of following 3 kinds of situations or more than one:
Ginseng/(dried orange peel+root of purple-flowered peucedanum) is 0.4-0.6;
Radix glycyrrhizae preparata/(Chinese yam+bamboo juice) is 0.12-0.25;
(ginseng+endothelium corneum gigeriae galli)/bamboo juice is 0.6-1.1.
Preferably, the composition be using ginseng, Chinese yam, endothelium corneum gigeriae galli, dried orange peel, radix glycyrrhizae preparata, the root of purple-flowered peucedanum, bamboo juice as bulk pharmaceutical chemicals,
Pharmaceutically acceptable auxiliary material is added, the preparation being conventionally prepared.
Preferably, the preparation is oral preparation.
A kind of preparation method of composition for infantile respiratory tract infection repeatedly of the present invention, comprising the following steps:
Step 1: preparation raw material by weight;
Step 2. adds water to cook ginseng, Chinese yam, endothelium corneum gigeriae galli, dried orange peel, radix glycyrrhizae preparata, the root of purple-flowered peucedanum, filtering, and bamboo is added in filtrate
Drip, after mixing, be concentrated, packing, sterilizing to get.
Composition of the present invention is in preparation for the application in the drug of infantile respiratory tract infection repeatedly, food.This
Ginseng described in invention is the dry root and rhizome of Araliaceae ginseng Panax ginseng C.A.Mey..More than autumn
Excavation is cleaned and is dried or dried.Cultivation is commonly called as " garden ginsent ";Sow the title " hayashishita grown naturally under mountain forest wild state
Wild ginseng " is practised and claims " seed sea ".Ginseng is sweet in flavor, slight bitter, tepor.Returns spleen, lung, the heart, kidney channel.Function with the major functions: reinforce vital energy, multiple arteries and veins
Prevent prolapse reinforces the spleen to benefit the lung, shengjin nourishing, tranquilize the mind and promote the intelligence.It to be taken off for physically weak, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung is breathed with cough, saliva wound
Thirsty, Heat Diabetes, deficiency of qi and blood, prolonged illness void is thin, insomnia of palpitating with fear, impotence palace cold.
Heretofore described Chinese yam is the dry root of Dioscoreaceae plant Chinese yam Dioscorea opposita Thun b.
Stem.Taste sweet and neutral.Returns spleen, lung, kidney channel.Function with the major functions: tonifying spleen nourishing the stomach, engender liquid and benefic lung, kidney tonifying arresting seminal emission.For spleen eating less, long
It rushes down incessantly, the deficiency syndrome of the lung is breathed with cough, emission due to the kidney deficiency, leukorrhagia, frequent micturition, and abnormal heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney.For spleen eating less, let out
Rush down loose stool, leukorrhea.
Heretofore described endothelium corneum gigeriae galli is Phasianidae animal family chicken Callus gallus domesticus Brisson's
Dry inner wall of sandbag.After killing chicken, chicken gizzard is taken out, immediately inner wall under capsule, cleaning, drying.Taste sweet and neutral.Returns spleen, stomach, small intestine, bladder
Through.Function with the major functions: stomach strengthening and digestion promoting, arresting seminal emission, treating stranguria fossil.For dyspepsia, vomiting dysentery, infantile malnutrition, the enuresis,
Spermatorrhea, the puckery pain of urolithiasis, distension of gallbladder, hypochondriac pain.
Heretofore described dried orange peel is rutaceae orange Citrus reticulata Blanco and its variety
Dry mature skin.Medicinal material is divided into " dried orange peel " and " citrus chachiensis hortorum ".Harvesting ripe fruit strips pericarp, sun drying or low temperature drying.
It is bitter, acrid in flavour and warm in nature.Return lung, the spleen channel.Function with the major functions: regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm.For abdominal fullness and distention, deficiency of food is vomited and diarrhoea, cough
Abundant expectoration.
Heretofore described radix glycyrrhizae preparata is the Preparation process product of Radix Glycyrrhizae.Taste sweet and neutral.Return heart, lung, spleen, stomach meridian.Function with
The major functions: tonifying spleen stomach function regulating, Yiqi and vein recovery.Weak, fatigue and weakness, severe palpilation, knotted pulse for spleen helmet.Wherein, Radix Glycyrrhizae is pulse family plant
Object Radix Glycyrrhizae Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza inflata Bat. or glycyrrhiza glabra
The dry root and rhizome of Glycyrrhiza glabra L..
The heretofore described root of purple-flowered peucedanum is umbelliferae RADIX PEUCEDANI Peucedanum praeruptorum Dunn's
Dry root.Excavation when winter to secondary spring cauline leaf withers or do not take out scape, removes fibrous root, cleans, sun drying or low temperature drying.Bitter,
It is pungent, it is slightly cold.It is distributed in lung channel.Function with the major functions: lowering the adverse-rising QI to resolve phlegm, relieve heat heat-clearing.Full for phlegm heat panting, slightly phlegm Huang is thick, cough due to wind-heat evil's phlegm
It is more.Heretofore described bamboo juice is Gramineae plant phyllostachys glauca McClure Phyllostachys glauca McClure, net bamboo
The liquid leached naturally after Phyllostachys nuda McClure and the fresh bar for belonging to several plants are heated.It is sweet in flavor, property
It is cold.Have the function of clearing heat and eliminating phlegm, be used for cough with lung heat's abundant expectoration, pant uncomfortable in chest, apoplexy tongue is strong, accumulation and obstruction of sputum, and children's phlegm heat is frightened
Wind.
Pharmaceutically acceptable auxiliary material mentioned in the present invention, including " medicinal excipient handbook " (American Pharmaceutical Association,
In October, 1986), Chemical Industry Press publish " pharmaceutic adjuvant handbook " (Handbook of Pharmaceutical
Excipients, original work fourth edition) or " pharmaceutical necessities are complete works of " (Sichuan Publishing Group, Sichuan science tech publishing house publish,
In January, 2006) listed by auxiliary material, but be not limited to these auxiliary materials.
Compared with prior art, the invention has the following advantages:
Prescription science of the present invention, proportion is monarch with ginseng, Chinese yam is minister, and the root of purple-flowered peucedanum, bamboo juice, dried orange peel, endothelium corneum gigeriae galli are rationally
Assistant, radix glycyrrhizae preparata are to make medicine, each component synergistic effect, and the common effect for playing treatment infantile respiratory tract infection repeatedly is long-term to take
With safety.
Ginseng is sweet in flavor in the present invention, slight bitter, tepor, returns spleen, lung, the heart, kidney channel;It reinforces vital energy, reinforces the spleen to benefit the lung;Chinese yam taste
Sweet and neutral, returns spleen, lung, kidney channel, tonifying spleen nourishing the stomach, engender liquid and benefic lung.Chinese yam and ginseng compatibility, it is common to play solid centralizing qi, benifit lung spleen
The function of kidney.It is root of purple-flowered peucedanum bitter in the present invention, pungent, it is slightly cold, it is distributed in lung channel;Lowering the adverse-rising QI to resolve phlegm, relieve heat heat-clearing.The root of purple-flowered peucedanum and tonic ginseng,
Chinese yam compatibility, the intrusion of preventing diseases caused by external factors ailment said due to cold or exposure and influenza virus.Radix glycyrrhizae preparata taste sweet and neutral, return heart, lung, spleen, stomach meridian;With antiallergy
Effect, effectively prevent bronchial asthma breaking-out.Bamboo juice is sweet in flavor, cold in nature, clearing heat and eliminating phlegm;It can increase bronchus ciliary movement,
Sputum is discharged from trachea-bronchial epithelial cell.Dried orange peel bitter, acrid in flavour and warm in nature, return lung, the spleen channel, regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm;Endothelium corneum gigeriae galli taste
Sweet and neutral, returns spleen, stomach, small intestine, bladder meridian, stomach strengthening and digestion promoting.Dried orange peel and endothelium corneum gigeriae galli compatibility, play disperse accumulation altogether and help fortune, anti-dyspepsia
It induces children and sends out multiple respiratory tract infection.
In the present invention, ginseng, Chinese yam, endothelium corneum gigeriae galli, dried orange peel, radix glycyrrhizae preparata, bamboo juice have long-term edible history, and safety is good
It is good.
Present invention employs oral preparations, facilitate production, storage, transport, carry and take.
Specific embodiment
Below with reference to embodiment, the invention will be further described, and mode of the invention includes but are not limited to following implementation
Example.
Embodiment 1
Present embodiment discloses the raw material of composition of the invention compositions, are specifically shown in Table 1:
Table 1
Embodiment 2
Present embodiment discloses the preparation method of composition of the invention, specifically:
Step 1: preparation raw material by weight;
Step 2. adds water to cook ginseng, Chinese yam, endothelium corneum gigeriae galli, dried orange peel, radix glycyrrhizae preparata, the root of purple-flowered peucedanum three times, adds 8 times of amount decoctings every time
It boils 2 hours, filters, bamboo juice is added into filtrate for merging filtrate, and after mixing, being concentrated into density is 1.08-1.12 (60 DEG C)
Concentrate, packing, sterilizing to get.
In the present embodiment, after 0.3% potassium sorbate can also being added in concentrate, then dispenses, sterilizes.
Embodiment 3
Present embodiment discloses the preparation method of composition of the invention, specifically:
Step 1: preparation raw material by weight;
Ginseng, Chinese yam, endothelium corneum gigeriae galli, dried orange peel, radix glycyrrhizae preparata, the root of purple-flowered peucedanum are added 65%-85% ethanol solution refluxing extraction by step 2.
Three times, the ethanol solutions of 6 times of amounts are added to extract every time 1.5 hours, filtering, merging filtrate, after recycling ethyl alcohol, addition bamboo juice mixing is equal
It is even, be further concentrated to density be 1.08-1.12 (60 DEG C) concentrate, packing, sterilizing to get.
In the present embodiment, after 0.3% sorbitol can also being added in concentrate, then dispenses, sterilizes.
Embodiment 4
Present embodiment discloses the preparation method of composition of the invention, specifically:
Step 1: preparation raw material by weight;
Ginseng, Chinese yam, endothelium corneum gigeriae galli, dried orange peel, radix glycyrrhizae preparata, the root of purple-flowered peucedanum are added water to cook secondary, each plus 6 times of amount decoctings by step 2.
It boils 1 hour, filters, bamboo juice is added into filtrate for merging filtrate, and after mixing, being concentrated into density is 1.25-1.30 (60 DEG C)
Thick paste, the dextrin of 2 times of quality of thick paste is added, is uniformly mixed, wet granulation is dry, packing to get.
Embodiment 5
Using the formula of serial number 8 in table 1, using the method for embodiment 2, mouth made of potassium sorbate is not added in preparation
Take liquid.The every ml of gained sample is equivalent to crude drug in whole 2.5g.
Embodiment 6
Using the formula of serial number 9 in table 1, using the method for embodiment 3, mouth made of potassium sorbate is not added in preparation
Take liquid.The every ml of gained sample is equivalent to crude drug in whole 4g.
Embodiment 7
Present embodiment discloses clinical applications of the invention.
Xu of case 1. certain, male 9 months 3 years old, goes to a doctor April 5 2017 date.
Present illness history: every month will catch a cold 1 time after children 1 years old, and cardinal symptom is exactly first to have a fever, and burning is stepped back to be sent out with regard to tonsillotome
Inflammation, and cough, it coughs very violent.Need continuous oral and injection drug that could fully recover more than 1 week.
Check: ordinary circumstance is fine, and 36.6 DEG C of body temperature, pharynx is slightly red, and cardiopulmonary are normal, and for abdomen without tenderness, remaining is normal.
Diagnosis: repeated respiratory infections.
Treatment: the sample prepared using the embodiment of the present invention 5 is taken orally, sooner or later primary, bfore meals, each 1ml.January
For 1 course for the treatment of.
Curative effect: after the medication of this infant, three middle of the month only catch a cold 1 time, and respiratory tract infection does not occur.And symptom is very light, only table
It is now runny nose, does not have a fever, tonsillotome is not red and swollen, does not cough, and oral cold drug is fully recovered.9 middle of the month have suffered from afterwards catches a cold twice,
Respiratory tract infection does not occur.Symptom is very light, does not have a fever, and tonsillotome is not red and swollen, does not cough, and oral cold drug is fully recovered.
Embodiment 8
Present embodiment discloses clinical applications of the invention.
Case 2
1. Chen of case, female 4 months 5 years old, go to a doctor May 2 2017 date.
Present illness history: having suffered from Bronchopneumonia from 2 years old and be hospitalized, and will be hospitalized every year 2 times, usually monthly catches a cold 1 time, after flu
With regard to cough, pant, have phlegm, need continuous oral and injection drug could fully recover more than 1 week.
Check: ordinary circumstance is fine, and for tonsillotome without enlargement, cardiopulmonary are normal, and for abdomen without tenderness, remaining is normal.
Diagnosis: repeated respiratory infections.
Treatment: the sample prepared using the embodiment of the present invention 6 is taken orally, sooner or later primary, bfore meals, each 4ml.January
For 1 course for the treatment of.
Curative effect: infant starts follow-up always after treatment.After the medication of this infant, three middle of the month catch a cold 2 times, and respiratory tract does not occur
Infection.Symptoms are mild, not and hospitalization standard, does not show as runny nose, does not have a fever, and tonsillotome is slightly red and swollen, slightly coughs, and takes orally sense
Drug is emitted just to fully recover.9 middle of the month have suffered from afterwards catches a cold twice, and respiratory tract infection does not occur, and also non-hospitalization, shows as runny nose,
It does not have a fever, tonsillotome is not red and swollen, slightly coughs, the recovery from illness of oral cold drug.
Embodiment 9
Present embodiment discloses clinical applications of the invention.
Case 3
1. Liu of case, female 5 months 3 years old, go to a doctor May 8 2017 date.
Present illness history: children begin to catch a cold from 1 wheat harvesting period of birth, and cardinal symptom is runny nose, fever, send out later with regard to tonsillotome
Inflammation, cough.It monthly catches a cold 1 time, has suffered from Bronchopneumonia within every year old and be hospitalized, to be hospitalized every year 2 times.
Check: ordinary circumstance is fine, and 36.8 DEG C of body temperature, tonsillotome is without enlargement, and pharyngeal no hyperemia, no oedema, cardiopulmonary are normal,
For abdomen without tenderness, remaining is normal.
Diagnosis: repeated respiratory infections.
Treatment: the sample prepared using the embodiment of the present invention 5 is taken orally, sooner or later primary, bfore meals, each 1ml.January
For 1 course for the treatment of.
Curative effect: infant starts follow-up always after treatment.After the medication of this infant, three middle of the month catch a cold 1 time, and respiratory tract does not occur
Infection.Symptoms are mild, and not and hospitalization standard, Symptoms are runny nose, are not had a fever, and tonsillotome is slightly red and swollen, coughs unknown
Aobvious, oral cold drug is just fully recovered.Oral drugs are just fully recovered.9 middle of the month have suffered from afterwards catches a cold three times, and respiratory tract infection does not occur.
And this catch a cold three times after tonsillotome do not have an enlargement, unobvious, non-hospitalization of coughing, the recovery from illness of oral cold drug.
Embodiment 10
Present embodiments provide the statistical data using present composition treatment infantile respiratory tract infection repeatedly.
The infant for being diagnosed as repeated respiratory infections is randomly divided into test group and negative control group.
Test group is treated using composition of the invention, and treatment method is after throwing off a cold, to take drug one of the present invention
The moon is as a treatment course.During the course for the treatment of, if caught a cold again, deactivates drug of the present invention and taken again after throwing off a cold, it is preceding
Time of Administration amounts to one month afterwards.
Negative control group is not take any drug after throwing off a cold.
It cures: treating in latter year the infection of the upper respiratory tract 1-2 times, no lower respiratory tract infection.
It is effective: treat the infection of the upper respiratory tract≤3 time in latter year, lower respiratory tract infection 1 time.Symptom mitigates earlier above, continues
Time is short, easily cures.
It improves: treating the infection of the upper respiratory tract≤4 time in latter year, lower respiratory tract infection 1-2 times.
Invalid: pretherapy and post-treatment clinical symptoms are unchanged.
2 clinical test results table of table
As seen from the above table, the present invention can effectively treat infantile respiratory tract infection repeatedly.
Above-described embodiment is only one of the preferred embodiment of the present invention, should not be taken to limit protection model of the invention
It encloses, as long as that in body design thought of the invention and mentally makes has no the change of essential meaning or polishing, is solved
The technical issues of it is still consistent with the present invention, should all be included within protection scope of the present invention.
Claims (10)
1. a kind of composition for infantile respiratory tract infection repeatedly, which is characterized in that by the raw material system including following parts by weight
At: 5-50 parts of ginseng, 10-80 parts of Chinese yam, 10-60 parts of endothelium corneum gigeriae galli, 5-60 parts of dried orange peel, 5-30 parts of radix glycyrrhizae preparata, 5-40 parts of the root of purple-flowered peucedanum, bamboo
20-120 parts of drip.
2. a kind of composition for infantile respiratory tract infection repeatedly according to claim 1, which is characterized in that by including
The raw material of following parts by weight is made: 8-35 parts of ginseng, 15-65 parts of Chinese yam, and 15-50 parts of endothelium corneum gigeriae galli, 8-45 parts of dried orange peel, radix glycyrrhizae preparata 8-
25 parts, 8-35 parts of the root of purple-flowered peucedanum, 25-105 parts of bamboo juice.
3. a kind of composition for infantile respiratory tract infection repeatedly according to claim 2, which is characterized in that by including
The raw material of following parts by weight is made: 10 parts of ginseng, 20 parts of Chinese yam, and 20 parts of endothelium corneum gigeriae galli, 10 parts of dried orange peel, 10 parts of radix glycyrrhizae preparata, the root of purple-flowered peucedanum 10
Part, 30 parts of bamboo juice.
4. a kind of composition for infantile respiratory tract infection repeatedly according to claim 2, which is characterized in that by including
The raw material of following parts by weight is made: 30 parts of ginseng, 60 parts of Chinese yam, and 40 parts of endothelium corneum gigeriae galli, 40 parts of dried orange peel, 20 parts of radix glycyrrhizae preparata, the root of purple-flowered peucedanum 30
Part, 100 parts of bamboo juice.
5. a kind of composition for infantile respiratory tract infection repeatedly according to claim 1, which is characterized in that the original
The dosage of material meet one of following 3 kinds of situations or more than one:
Ginseng/(dried orange peel+root of purple-flowered peucedanum) is 0.3-0.7;
Radix glycyrrhizae preparata/(Chinese yam+bamboo juice) is 0.1-0.3;
(ginseng+endothelium corneum gigeriae galli)/bamboo juice is 0.48-1.5.
6. a kind of composition for infantile respiratory tract infection repeatedly according to claim 5, which is characterized in that the original
The dosage of material meet one of following 3 kinds of situations or more than one:
Ginseng/(dried orange peel+root of purple-flowered peucedanum) is 0.4-0.6;
Radix glycyrrhizae preparata/(Chinese yam+bamboo juice) is 0.12-0.25;
(ginseng+endothelium corneum gigeriae galli)/bamboo juice is 0.6-1.1.
7. a kind of composition for infantile respiratory tract infection repeatedly, feature described in -6 any one according to claim 1
It is, the composition is added pharmaceutically using ginseng, Chinese yam, endothelium corneum gigeriae galli, dried orange peel, radix glycyrrhizae preparata, the root of purple-flowered peucedanum, bamboo juice as bulk pharmaceutical chemicals
Acceptable auxiliary material, the preparation being conventionally prepared.
8. a kind of composition for infantile respiratory tract infection repeatedly according to claim 7, which is characterized in that the system
Agent is oral preparation.
9. a kind of preparation method of the composition for infantile respiratory tract infection repeatedly described in -7 any one according to claim 1,
Characterized by comprising the following steps:
Step 1: preparation raw material by weight;
Step 2. adds water to cook ginseng, Chinese yam, endothelium corneum gigeriae galli, dried orange peel, radix glycyrrhizae preparata, the root of purple-flowered peucedanum, filtering, and bamboo juice is added in filtrate, mixes
Close uniformly after, be concentrated, packing, sterilizing to get.
10. drug, food that composition described in any one of claim 1-9 is used for infantile respiratory tract infection repeatedly in preparation
In application.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811249802.0A CN109091633B (en) | 2018-10-25 | 2018-10-25 | Composition for treating recurrent respiratory tract infection of children and preparation method and application thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811249802.0A CN109091633B (en) | 2018-10-25 | 2018-10-25 | Composition for treating recurrent respiratory tract infection of children and preparation method and application thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109091633A true CN109091633A (en) | 2018-12-28 |
CN109091633B CN109091633B (en) | 2021-08-03 |
Family
ID=64869430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811249802.0A Active CN109091633B (en) | 2018-10-25 | 2018-10-25 | Composition for treating recurrent respiratory tract infection of children and preparation method and application thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109091633B (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104906456A (en) * | 2015-06-30 | 2015-09-16 | 孙霞 | Traditional Chinese medicine for treating respiratory tract infection of children |
CN105617146A (en) * | 2016-01-21 | 2016-06-01 | 刘建新 | Traditional Chinese medicine composition for preventing and treating infantile recurrent respiratory tract infection and preparation method thereof |
-
2018
- 2018-10-25 CN CN201811249802.0A patent/CN109091633B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104906456A (en) * | 2015-06-30 | 2015-09-16 | 孙霞 | Traditional Chinese medicine for treating respiratory tract infection of children |
CN105617146A (en) * | 2016-01-21 | 2016-06-01 | 刘建新 | Traditional Chinese medicine composition for preventing and treating infantile recurrent respiratory tract infection and preparation method thereof |
Non-Patent Citations (3)
Title |
---|
任麦存等: "加味玉屏风散治疗小儿反复呼吸道感染86例", 《中国社区医师(综合版)》 * |
甄穗清: "人参五味子汤防治小儿反复呼吸道感染", 《实用医学杂志》 * |
盛丽先主编: "《盛丽先儿科临证经验》", 31 July 2017, 浙江科学技术出版社 * |
Also Published As
Publication number | Publication date |
---|---|
CN109091633B (en) | 2021-08-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100404067C (en) | Traditional medicine preparation for treating children's pulmonary disease | |
CN103405738B (en) | Pharmaceutical composition for treating chronic cholecystitis | |
CN105641149A (en) | Toxin-removing oral liquid containing fineleaf schizonepeta herbs and divaricate saposhnikovia roots and preparation method of oral liquid | |
CN1318071C (en) | Chinese medicine preparation for treating bronchitis | |
CN102641366A (en) | Traditional Chinese medicine composition for preventing and treating proventriculitis and gizzard erosion of poultry | |
CN104256165A (en) | Functional feed for preventing and treating chronic swine plague and preparation method of functional feed | |
CN102935106A (en) | Traditional Chinese medicine or food with function of regulating spleens, stomachs and intestines and preparation method and application thereof | |
CN109223886A (en) | Chinese medicine composition and its preparation method and application for invigorating the spleen to arrest diarrhea | |
CN102935193B (en) | Traditional Chinese medicine or food with functions of tonifying spleens, helping digestion, relaxing bowels and expelling toxins and preparation method and application thereof | |
CN101524479B (en) | Medicine for curing avian infectious bronchitis | |
CN109091633A (en) | It is a kind of for the composition and preparation method of infantile respiratory tract infection repeatedly and application | |
CN103989762B (en) | Chinese medicine composition of internal organs relieving cough and resolving phlegm and preparation method thereof is rushed down in a kind of heat clearing away | |
CN102988856A (en) | Medicine for treating infantile salivation | |
Rao et al. | Folklore traditional knowledge on digestive disorders of domestic animals (cattle, sheep and goats) in the Medak district, Telangana, India | |
CN104587342A (en) | Medicinal liquor suitable for being drunk by patients with hyperthyroidism and preparation process thereof | |
CN108653457B (en) | Traditional Chinese medicine composition for treating infantile malnutrition | |
CN107519429B (en) | Have the function of to improve taste and promote the Chinese medicine composition and preparation method of catharsis and toxin expelling | |
CN103721153A (en) | Traditional Chinese medicinal composition for resisting swine virus infection | |
CN1329050C (en) | Medication of eliminating stagnated food and preparation method | |
CN105250749A (en) | Traditional Chinese medicine for treating thyroid adenoma and preparation method thereof | |
CN110448616A (en) | A kind of production method of traditional Chinese medicine formula that treating five black infectious laryngotracheitis of chickens | |
CN102935194B (en) | Traditional Chinese medicine or food for promoting digestion function and detoxifying and beautifying as well as preparation method and applications thereof | |
CN113559192A (en) | Digestion-aiding powder suitable for loss of appetite | |
CN100486619C (en) | Combination of medication for treating tumorous diseases and preparation method | |
CN109692277A (en) | A kind of Chinese herbal and crude drugs preparations for treating diabetes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |