CN108495559A - 甜菊醇糖苷组合物 - Google Patents

甜菊醇糖苷组合物 Download PDF

Info

Publication number
CN108495559A
CN108495559A CN201680067837.5A CN201680067837A CN108495559A CN 108495559 A CN108495559 A CN 108495559A CN 201680067837 A CN201680067837 A CN 201680067837A CN 108495559 A CN108495559 A CN 108495559A
Authority
CN
China
Prior art keywords
steviol glycoside
taste
steviol
composition
small amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680067837.5A
Other languages
English (en)
Inventor
S·普尔卡亚斯塔
J·马丁
M·珀蒂
K·奇卡罕
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PureCircle USA Inc
Original Assignee
PureCircle USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PureCircle USA Inc filed Critical PureCircle USA Inc
Priority to CN202210989662.0A priority Critical patent/CN115336734A/zh
Priority to CN202210989660.1A priority patent/CN115299547A/zh
Publication of CN108495559A publication Critical patent/CN108495559A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/36—Terpene glycosides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/12—Replacer
    • A23V2200/132—Sugar replacer
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/15—Flavour affecting agent
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/24—Non-sugar sweeteners
    • A23V2250/258—Rebaudioside
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/24—Non-sugar sweeteners
    • A23V2250/262—Stevioside

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Seasonings (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

描述了具有改善的甜味和风味特征的甜菊醇糖苷组合物。

Description

甜菊醇糖苷组合物
发明背景
本发明涉及少量甜菊醇糖苷对甜菊甜味剂的甜味特征的积极影响。
由于意识到许多疾病与食用高糖食物和饮料相关，糖替代品正受到日益增加的关注。然而，由于对其安全性的关注，许多人造甜味剂，如甘素、环己氨基磺酸钠和糖精在一些国家是被禁止或限制的。因此，天然来源的无热量甜味剂正变得越来越普遍。甜味草本植物甜菊(Stevia rebaudiana)产生若干双萜糖苷，其特征在于高强度甜味和优于许多其他强效甜味剂甜度的感官性能。
甜菊是属于卫矛科(Astracea)的植物物种，其是南美洲天然的，并且现在在全世界的许多地方种植(Gardana等，2003；Koyama等，2003；Carakostas等，2008)。甜菊叶是天然甜味的，并且在南美洲用于食品增甜已经有几百年了(Soejarto等，1982)。在日本和其他东南亚国家，多年来甜菊提取物已经在商业上用于食品增甜(Koyama等，2003)。作为自然的产物，甜菊植物叶含有不同甜味组分，称为甜菊醇糖苷。据报道，已经鉴定出通常有超过40种甜菊醇糖苷存在于甜菊叶提取物中(Ceunen和Geuns，2013；Chaturvedula等，2011a,b,c；Chaturvedula和Prakash，2011a,b；Ohta等，2010)。这些甜菊醇糖苷中的每一种都具有其自身独特的味道特征和甜味强度，其可以比糖高达350倍，但全部共同具有相似的分子结构，其中不同的糖部分连接于糖苷配基甜菊醇(内根-贝壳杉烯(ent-kaurene)-型双萜)上。甜菊醇糖苷的通用结构呈现于图1中。
莱鲍迪苷A和甜菊苷获得了最大的商业关注，并就其作为商业高强度甜味剂的适合性进行了广泛研究和表征。在碳酸饮料中的稳定性研究证实了它们的热和pH稳定性(Chang S.S.，Cook，J.M.(1983)Stability studies of stevioside and rebaudioside Ain carbonated beverages(甜菊苷和莱鲍迪苷A在碳酸饮料中的稳定性研究)，J.Agric.Food Chem.31:409-412)。
甜菊醇糖苷不仅彼此的分子结构不同，而且其味道特性也不同。通常，发现甜菊苷比蔗糖甜110-270倍，并且莱鲍迪苷A比蔗糖甜150至320倍。莱鲍迪苷A具有最少的涩味、最少的苦味和最少的持续后味，因此在主要的甜菊醇糖苷中具有最令人满意的感官属性(Tanaka O.(1987)Improvement of taste of natural sweeteners(天然甜味剂的味道改善)，Pure Appl.Chem.69:675-683；Phillips K.C.(1989)Stevia:steps in developing anew sweetener.见:Grenby T.H.编辑，Developments in sweeteners，第3卷，ElsevierApplied Science，伦敦，1-43)。
到21世纪早期，只有有限数量的甜菊中的甜菊醇糖苷的化学结构得到了表征，包括甜菊苷、莱鲍迪苷A-F、杜克苷A和甜菊双糖苷(Geunen和Geuns，2013)。近年来，报道了来自甜菊叶的具有不同化学结构的许多少量甜菊醇糖苷(Chaturvedula等，2011a,b,c；Chaturvedula和Prakash，2011a,b)。这些不同的甜菊醇糖苷，其是内根-贝壳杉烯-型双萜，经由1,2-；1,3-；1,4-或1,6-α或β-配糖键在C-13和C-19位置与各种糖相连，如葡萄糖、鼠李糖、木糖、果糖和脱氧葡萄糖。各种甜菊醇糖苷的性质和分组概括于表1中。由于大量的甜菊醇糖苷，根据与甜菊醇主链连接的糖部分，表1列出了5组甜菊醇糖苷，并用缩写的组成名称来识别。
·葡糖基甜菊醇家族：只包括甜菊醇和葡萄糖残基。这组可以通过通式“SvGn”来呈现，其中Sv是甜菊醇，而G是葡萄糖。
·鼠李糖基甜菊醇家族：包括甜菊醇、鼠李糖和葡萄糖残基。这组可以通过通式“SvR1Gn”来呈现，其中R是鼠李糖。
·木糖基甜菊醇家族：包括甜菊醇、木糖和葡萄糖残基。这组可以通过通式“SvX1Gn”来表示，其中X是木糖。
·果糖基甜菊醇家族：包括甜菊醇、果糖和葡萄糖残基。这组可以通过通式“SvF1Gn”来表示，其中F是果糖。
·脱氧葡萄糖甜菊醇家族：包括甜菊醇、脱氧葡萄糖和葡萄糖残基。这组可以通过通式SvdG1Gn来呈现。
表1
发明概述
本发明涉及改善甜菊醇糖苷甜味剂(如甜菊苷和莱鲍迪苷A(Reb A))的甜味特征。出乎预料地发现了某些少量甜菊醇糖苷对其他甜菊醇糖苷，包括莱鲍迪苷D(Reb D)和莱鲍迪苷M(Reb M)的甜味特征具有有利的影响。这些少量甜菊醇糖苷，尽管少量存在，但证明了对甜菊甜味剂的甜味特征的统计学显著的积极影响。如本文中使用的，少量甜菊醇糖苷是以低于5％或低于2％的量存在于组合物中的甜菊醇糖苷。
附图简述
图1显示了甜菊醇糖苷的通用结构。
图2a显示了莱鲍迪苷N的结构。图2b显示了莱鲍迪苷Q的结构。
图3a是显示出品尝小组结果的条形图。第一条表示来自品尝酸化水中的高度纯化的(至少97％纯的)莱鲍迪苷A组合物的结果。第二条表示来自品尝酸化水中的果糖化莱鲍迪苷A组合物的结果。
图3b是显示出品尝小组结果的条形图。第一条表示来自品尝包括高度纯化的RebM/Reb D混合物的减肥柠檬-酸橙碳酸软饮料的结果，其中所述混合物包括50％重量Reb M和50％重量Reb D。第二条表示来自品尝包括果糖化莱鲍迪苷A组合物的减肥柠檬-酸橙碳酸软饮料的结果。
图4a是显示出品尝小组结果的条形图。第一条表示来自品尝酸化水中的高度纯化的(至少97％纯的)莱鲍迪苷A组合物的结果。第二条表示来自品尝酸化水中的糖基化少量甜菊醇糖苷组合物的结果，其中所述糖基化少量甜菊醇糖苷组合物含有19％重量糖基化Reb Q和18％重量糖基化Reb R。
图4b是显示出品尝小组结果的条形图。第一条表示来自品尝包括高度纯化的RebM/Reb D混合物的减肥柠檬-酸橙碳酸软饮料的结果，其中所述混合物包括50％重量Reb M和50％重量Reb D。第二条表示来自品尝酸化水中包括糖基化少量甜菊醇糖苷的减肥柠檬-酸橙碳酸软饮料的结果，其中所述糖基化少量甜菊醇糖苷组合物含有19％重量糖基化RebQ和18％重量糖基化Reb R。
详述
发现包括少量糖苷(如莱鲍迪苷N和莱鲍迪苷Q)的甜菊醇糖苷组合物(SG组合物)对甜菊甜味剂的甜味特征具有正面影响。示例性甜菊醇糖苷组合物描述于表2中。
表2：甜菊醇糖苷组合物(SG组合物)
Reb D/Reb M混合物与甜菊醇糖苷组合物的比较
实施例1：酸化水-5白利糖度靶
15名专家品尝了样品溶液，如表3中概括的：
表3：酸化水5白利糖度靶-SG组合物相对于Reb D和Reb M混合物
*＝80％置信区间，**＝90％置信区间，***＝95％置信区间
如可以看到的，甜菊醇糖苷组合物(SG组合物)具有许多比Reb D/Reb M混合物更类似于5％糖溶液的属性，并且整体相似性高于Reb D/Reb M混合物。具有少量糖苷和70/30Reb D/M混合物的甜菊醇糖苷组合物甜度相当。与SG组合物相比，Reb D/Reb M 70/30混合物具有明显更高的涩味、酸味、异味和甜味后味。这两种样品具有显著不同的风味特征。
实施例2：酸化水-10白利糖度靶
与实施例1一样进行了相同测试，但使用10白利糖度靶。13名专家品尝了该溶液，如表4中概括的。
表4：酸化水10白利糖度靶-SG组合物相对于Reb D和Reb M混合物
*＝80％置信区间，**＝90％置信区间，***＝95％置信区间
在此测试中，甜菊醇糖苷组合物和Reb D/Reb M混合物的糖度相似。与甜菊醇糖苷组合物相比，70/30混合物还具有明显更高的甜味后味。
尽管不打算受到理论的束缚，但认为莱鲍迪苷N和莱鲍迪苷O，尽管以少量存在于甜菊醇糖苷组合物中，对甜菊醇糖苷组合物的风味和甜度特征具有有利影响，特别是在5白利糖度靶水平下。莱鲍迪苷N和莱鲍迪苷O的结构显示于图2a和2b中。然而，即使在10白利糖度靶下，也观察到了某些优势，使得这些少量甜菊醇糖苷在甜味特征改善中是有重大意义的。
实施例3：果糖化甜菊醇糖苷
发现了将一个或多个果糖分子添加至莱鲍迪苷A提供了风味和甜味特征优势。认为莱鲍迪苷A或其他甜菊醇糖苷(包括少量甜菊醇糖苷)的果糖化可以提供与高度纯化的甜菊醇糖苷类似于乃至优于高度纯化的甜菊醇糖苷的特征。使莱鲍迪苷A接受糖基化处理，以将果糖添加至G1和G2位置，并且与酸化水中的高度纯化的莱鲍迪苷A组合物以及减肥柠檬-酸橙碳酸软饮料中的高度纯化的Reb M/Reb D混合物进行比较。来自受过培训的测试专家小组的结果显示于图3a和3b中。
实施例4：糖基化的少量甜菊醇糖苷
发现除了它们对甜菊醇糖苷组合物的风味和甜味特征的有利影响外，当将它们糖基化时，可以提高少量糖苷的影响。糖基化甜菊醇糖苷(GSG)具有一个或多个连接于甜菊醇糖苷主链上的糖苷部分，并且发现了对甜菊醇糖苷组合物的如苦味、甜味后味等的属性具有有利影响。糖基化少量甜菊醇糖苷可以将甜菊醇糖苷组合物的风味和甜味特征改善至与高度纯化的甜菊醇糖苷的风味和甜味特征相似乃至超过高度纯化的甜菊醇糖苷的风味和甜味特征，由此提供高度纯化的甜菊醇糖苷的有效且高效的替代品。
糖苷部分可以是任何单糖、双糖或寡糖，如葡萄糖、果糖、鼠李糖、木糖等。糖苷部分可以是单个分子，或可以是分子链，例如，连接于甜菊醇糖苷上的2、3或4个葡萄糖单体。糖基化处理通常导致糖苷部分连接于甜菊醇糖苷上的C-13或C-19位置。
在一个实施方案中，将莱鲍迪苷A和少量甜菊醇糖苷组合物糖基化。少量甜菊醇糖苷含量包括约19％重量的糖基化莱鲍迪苷Q，以及约18％重量的糖基化莱鲍迪苷R。
通过受过培训的专家小组品尝含有不同含量的糖基化少量甜菊醇糖苷组合物的酸化水和减肥柠檬-酸橙糖苷组合物并且结果显示于图4a和4b中。如可以看到的，含有糖基化的少量甜菊醇糖苷的组合物在多个甜味和风味属性上与高度纯化的甜菊醇糖苷组合物(Reb A和Reb M/Reb D)几乎相同，并且在一些情况中，甚至更优。
应当理解本文中显示的之前的描述和特定的实施方案仅仅是本发明最佳方式及其原理的说明，并且所述修改和添加可以容易地由本领域技术人员来进行，而不脱离本发明的精神和范围，因此应当理解本发明的范围仅受所附权利要求的范围来限制。

Claims (7)

1.甜菊醇糖苷组合物，其包括少量甜菊醇糖苷。
2.权利要求1的甜菊醇糖苷组合物，其中所述少量甜菊醇糖苷包括莱鲍迪苷N和莱鲍迪苷O。
3.权利要求1的甜菊醇糖苷组合物，其中所述少量甜菊醇糖苷包括莱鲍迪苷Q和莱鲍迪苷R。
4.权利要求1的甜菊醇糖苷组合物，其中至少一种少量甜菊醇糖苷是糖基化的。
5.用于改善甜菊甜味剂的甜味特征的方法，包括在甜菊甜味剂中提供少量甜菊醇糖苷。
6.权利要求1的组合物，其中所述少量甜菊醇糖苷提供比莱鲍迪苷D和莱鲍迪苷M的对比混合物更类似于糖溶液的涩味、酸味、异味、苦味后味和甜味后味味道属性。
7.权利要求4的组合物，其中所述糖基化的甜菊醇糖苷与莱鲍迪苷A的对比组合物相比提供降低的苦味、涩味、异味和苦味后味味道属性。
CN201680067837.5A 2015-10-26 2016-10-26 甜菊醇糖苷组合物 Pending CN108495559A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202210989662.0A CN115336734A (zh) 2015-10-26 2016-10-26 甜菊醇糖苷组合物
CN202210989660.1A CN115299547A (zh) 2015-10-26 2016-10-26 甜菊醇糖苷组合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562246412P 2015-10-26 2015-10-26
US62/246,412 2015-10-26
US201562255838P 2015-11-16 2015-11-16
US62/255,838 2015-11-16
PCT/US2016/058834 WO2017075034A1 (en) 2015-10-26 2016-10-26 Steviol glycoside compositions

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202210989662.0A Division CN115336734A (zh) 2015-10-26 2016-10-26 甜菊醇糖苷组合物
CN202210989660.1A Division CN115299547A (zh) 2015-10-26 2016-10-26 甜菊醇糖苷组合物

Publications (1)

Publication Number Publication Date
CN108495559A true CN108495559A (zh) 2018-09-04

Family

ID=58631034

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201680067837.5A Pending CN108495559A (zh) 2015-10-26 2016-10-26 甜菊醇糖苷组合物
CN202210989660.1A Pending CN115299547A (zh) 2015-10-26 2016-10-26 甜菊醇糖苷组合物
CN202210989662.0A Pending CN115336734A (zh) 2015-10-26 2016-10-26 甜菊醇糖苷组合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202210989660.1A Pending CN115299547A (zh) 2015-10-26 2016-10-26 甜菊醇糖苷组合物
CN202210989662.0A Pending CN115336734A (zh) 2015-10-26 2016-10-26 甜菊醇糖苷组合物

Country Status (9)

Country Link
US (2) US11647771B2 (zh)
EP (2) EP3367816B1 (zh)
CN (3) CN108495559A (zh)
BR (2) BR122020008481B1 (zh)
ES (1) ES2970118T3 (zh)
MX (2) MX2018005148A (zh)
PL (1) PL3367816T3 (zh)
RU (1) RU2731068C2 (zh)
WO (1) WO2017075034A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108712864A (zh) * 2015-12-15 2018-10-26 谱赛科美国股份有限公司 甜菊醇糖苷组合物
CN109349596A (zh) * 2018-09-29 2019-02-19 四川盈嘉合生科技有限公司 甜味剂组合物

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018144679A2 (en) 2017-02-03 2018-08-09 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
WO2023277680A1 (en) * 2021-06-29 2023-01-05 Purecircle Sdn Bhd High-purity steviol glycosides
WO2023014926A1 (en) 2021-08-05 2023-02-09 Corn Products Development, Inc. Flavor modifying composition
WO2024026450A1 (en) 2022-07-29 2024-02-01 Corn Products Development, Inc. Flavor modifying composition

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101742924A (zh) * 2007-05-22 2010-06-16 可口可乐公司 具有增强的甜味和改进的时间和/或风味概况的增甜剂组合物
CN102216313A (zh) * 2008-10-03 2011-10-12 守田化学工业株式会社 新的甜菊醇糖苷
CN102894325A (zh) * 2011-07-25 2013-01-30 成都华高瑞甜科技有限公司 复合甜味剂和制法、及改善甜菊糖苷类甜味剂口感的方法
WO2014122227A2 (en) * 2013-02-06 2014-08-14 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
WO2014197898A1 (en) * 2013-06-07 2014-12-11 Purecircle Usa Inc. Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier

Family Cites Families (232)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2500173A (en) 1947-01-02 1950-03-14 Univ Minnesota Extraction of digitalis glycosides
US2615015A (en) 1948-11-08 1952-10-21 Sunkist Growers Inc Method of preparing water soluble alkoxyl substituted chalcone glycosides
US3723410A (en) 1970-12-01 1973-03-27 Amazon Natural Drug Co Method of producing stevioside
JPS51142570A (en) 1975-06-04 1976-12-08 Morita Kagaku Kogyo Method of imparting sweetness to food or pharmaceutical agent
JPS525800A (en) 1975-06-27 1977-01-17 Sanyo Kokusaku Pulp Co Ltd Method of purifying stevioside
JPS5283731A (en) 1976-01-01 1977-07-12 Ajinomoto Co Inc Rebaudiosides
JPS52100500A (en) 1976-02-18 1977-08-23 Japan Organo Co Ltd Purification and concentration of aqueous stevioside extract
JPS52136200A (en) 1976-05-12 1977-11-14 Daicel Chem Ind Ltd Extraction purification of stevioside
JPS5329912A (en) 1976-08-31 1978-03-20 Nippon Shinyaku Co Ltd Preparation of sterol-glycosides from vegetable material
JPS5338669A (en) 1976-09-16 1978-04-08 Toyo Soda Mfg Co Ltd Separation of natural sweetening agent
JPS5430199A (en) 1977-08-08 1979-03-06 Sanyo Kokusaku Pulp Co Ltd Purification of stevia sweetening agnet
JPS54132599A (en) 1978-04-04 1979-10-15 Sanyo Kokusaku Pulp Co Ltd Separation and purification of stevioside sweetening
US4219571A (en) 1978-06-15 1980-08-26 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Process for producing a sweetener
JPS5539731A (en) 1978-09-11 1980-03-19 Res Inst For Prod Dev Extraction of stevioside
JPS5581567A (en) 1978-12-13 1980-06-19 Res Inst For Prod Dev Extraction and purification of stevioside
JPS5592400A (en) 1978-12-29 1980-07-12 Daikin Ind Ltd Purification of stevioside
JPS55120770A (en) 1979-03-14 1980-09-17 Chisso Corp Purification of stevioside solution
JPS55138372A (en) 1979-04-13 1980-10-29 Chisso Corp Purification of stevioside solution
JPS55162953A (en) 1979-06-04 1980-12-18 Yamada Masami Preparation of stevioside
JPS607108B2 (ja) 1979-11-13 1985-02-22 不二サッシ株式会社 カ−テンウオ−ルの改装工法
JPS5699768A (en) 1980-01-09 1981-08-11 Hayashibara Biochem Lab Inc Preparation of steviol glycoside
JPS56109568A (en) 1980-02-01 1981-08-31 Maruzen Kasei Kk Purification of stevia sweetening substance
JPS56121454A (en) 1980-02-27 1981-09-24 Ajinomoto Co Inc Separation of stevioside and rebaudioside a by crystallization
JPS56121455A (en) 1980-02-27 1981-09-24 Ajinomoto Co Inc Separation of stevioside and rebaudioside a by crystallization
JPS56121453A (en) 1980-02-27 1981-09-24 Ajinomoto Co Inc Separation of stevioside and rebaudioside a
JPS56160962A (en) 1980-05-14 1981-12-11 Dick Fine Chem Kk Purification of solution containing stevioside-type sweetening substance
JPS55159770A (en) 1980-05-26 1980-12-12 Res Inst For Prod Dev Extraction and purification of stevioside
JPS572656A (en) 1980-06-05 1982-01-08 Shinnakamura Kagaku Kogyo Kk Decoloration and purification of stevia extract
JPS575663A (en) 1980-06-13 1982-01-12 Res Inst For Prod Dev Purification of stevioside through extraction
JPS5746998A (en) 1980-09-04 1982-03-17 Fuji Food:Kk Preparation of stevioside
US4454290A (en) 1980-09-22 1984-06-12 Dynapol Stevioside analogs
JPS5775992A (en) 1980-10-30 1982-05-12 Tama Seikagaku Kk Purification of stevioside
JPS5846310B2 (ja) 1980-11-19 1983-10-15 丸善化成株式会社 ステビア中の主要甘味成分を単離する方法
JPS57134498A (en) 1981-02-12 1982-08-19 Hayashibara Biochem Lab Inc Anhydrous crystalline maltitol and its preparation and use
US4361697A (en) 1981-05-21 1982-11-30 F. K. Suzuki International, Inc. Extraction, separation and recovery of diterpene glycosides from Stevia rebaudiana plants
JPS5820170A (ja) 1981-07-24 1983-02-05 Toshizo Fukushima 甘味料の製法
JPS5828247A (ja) 1981-08-10 1983-02-19 Mitsubishi Acetate Co Ltd ステビオサイド溶液の精製方法
JPS5828246A (ja) 1981-08-10 1983-02-19 Mitsubishi Acetate Co Ltd ステビオサイドの製造方法
JPS58149697A (ja) 1982-02-27 1983-09-06 Dainippon Ink & Chem Inc β−１，３グリコシルステビオシドの製造方法
JPS58212759A (ja) 1982-06-04 1983-12-10 Sekisui Chem Co Ltd ステビア甘味物質の精製方法
JPS58212760A (ja) 1982-06-04 1983-12-10 Sekisui Chem Co Ltd ステビア甘味物質の精製方法
JPS5945848A (ja) 1982-09-09 1984-03-14 Morita Kagaku Kogyo Kk 新天然甘味料の製造方法
GB8403612D0 (en) 1984-02-10 1984-03-14 Tate & Lyle Plc Sweetener
US4612942A (en) 1984-03-08 1986-09-23 Stevia Company, Inc. Flavor enhancing and modifying materials
US4657638A (en) 1985-07-29 1987-04-14 University Of Florida Distillation column
US4599403A (en) 1985-10-07 1986-07-08 Harold Levy Method for recovery of stevioside
JPS62166861A (ja) 1986-01-20 1987-07-23 Sanpack:Kk ステビア乾葉からの甘味成分抽出・精製法
ES2046979T3 (es) 1987-07-21 1994-02-16 Roger H Giovanetto Procedimiento para la obtencion de esteviosidos a partir de material vegetal bruto.
JP3111203B2 (ja) 1987-12-26 2000-11-20 中里 隆憲 ステビア新品種に属する植物
DE3810681A1 (de) 1988-03-29 1989-10-12 Udo Kienle Verfahren zur herstellung eines natuerlichen suessungsmittels auf der basis von stevia rebaudiana und seine verwendung
US5830523A (en) 1990-02-28 1998-11-03 Otsuka Pharmaceutical Co., Ltd. Low-calorie beverage composition
CN1024348C (zh) 1990-05-23 1994-04-27 孟凡彬 用普通树脂提取甜菊甙的新工艺
JPH0633309B2 (ja) * 1990-06-13 1994-05-02 北海道糖業株式会社 新規なステビオール配糖体、その製造方法及びこれを用いた甘味料
US5576042A (en) 1991-10-25 1996-11-19 Fuisz Technologies Ltd. High intensity particulate polysaccharide based liquids
CN1032651C (zh) 1993-09-21 1996-08-28 袁斯鸣 甜菊糖甙的精制方法
US5549757A (en) 1994-06-10 1996-08-27 Ingredient Technology Corporation Process for recrystallizing sugar and product thereof
JPH08214A (ja) 1994-06-17 1996-01-09 Ikeda Pan:Kk レバウディオサイドａ系甘味料およびその製造方法
JP3262458B2 (ja) 1994-07-29 2002-03-04 キヤノン株式会社 記録装置
CN1112565A (zh) 1995-03-06 1995-11-29 北京市环境保护科学研究院 膜法组合技术提取甜菊甙工艺
JP3352860B2 (ja) * 1995-10-19 2002-12-03 守田化学工業株式会社 α−グルコシル化ステビア甘味料
RU2111969C1 (ru) 1995-11-08 1998-05-27 Республиканская научно-исследовательская лаборатория по биологически активным веществам Способ получения стевиозида
US5962678A (en) 1996-09-13 1999-10-05 Alberta Research Council Method of extracting selected sweet glycosides from the Stevia rebaudiana plant
TW557327B (en) 1996-11-08 2003-10-11 Hayashibara Biochem Lab Kojibiose phosphorylase, its preparation and uses
JPH10271928A (ja) 1997-01-30 1998-10-13 Morita Kagaku Kogyo Kk ステビア・レバウディアナ・ベルトニーに属する新植物
JP2002262822A (ja) 1997-01-30 2002-09-17 Morita Kagaku Kogyo Kk 種子栽培可能なステビア品種の植物体から得られる甘味料
RU2156083C2 (ru) 1997-06-24 2000-09-20 Дмитриенко Николай Васильевич Способ получения экстракта из травы стевии
RU2123267C1 (ru) 1997-06-24 1998-12-20 Дмитриенко Николай Васильевич Способ получения концентрата экстракта из порошка травы стевии
JPH1131191A (ja) 1997-07-14 1999-02-02 Olympus Optical Co Ltd マルチメディア情報読取装置
US5972120A (en) 1997-07-19 1999-10-26 National Research Council Of Canada Extraction of sweet compounds from Stevia rebaudiana Bertoni
JP3646497B2 (ja) 1997-12-22 2005-05-11 味の素株式会社 顆粒状甘味料
CN1078217C (zh) 1998-02-18 2002-01-23 南开大学 吸附树脂法从甜菊糖中富集、分离菜鲍迪甙a
IT1304373B1 (it) 1998-05-13 2001-03-15 Eridania S P A Procedimento per la produzione di zucchero bianco commerciale apartire da sugo greggio di bietola microfiltrato o ultrafiltrato.
CN1098860C (zh) 1998-06-08 2003-01-15 江苏省中国科学院植物研究所 高品质甜菊糖甙分离富集工艺
JP2000236842A (ja) 1998-12-24 2000-09-05 Nippon Paper Industries Co Ltd ステビア甘味料
US6228996B1 (en) 1999-02-24 2001-05-08 James H. Zhou Process for extracting sweet diterpene glycosides
RU2167544C2 (ru) 1999-03-09 2001-05-27 Краснодарский научно-исследовательский институт хранения и переработки сельскохозяйственной продукции Способ получения экстракта из растения stevia rebaudiana bertoni для виноделия
JP3436706B2 (ja) 1999-03-26 2003-08-18 雪印乳業株式会社 高甘味度甘味料の苦味低減又は除去剤
US6318157B1 (en) 1999-04-23 2001-11-20 Advanced Bioanalytical Services, Inc. High-throughput parallel liquid chromatography system
US20020132320A1 (en) 2001-01-10 2002-09-19 Wang Peng George Glycoconjugate synthesis using a pathway-engineered organism
US7815956B2 (en) 2001-04-27 2010-10-19 Pepsico Use of erythritol and D-tagatose in diet or reduced-calorie beverages and food products
US20020187232A1 (en) 2001-05-01 2002-12-12 Thomas Lee Method of improving the taste of low-calorie beverages and food products
ES2335977T3 (es) 2001-04-27 2010-04-07 Pepsico, Inc. Uso de eritritol y de d-tagatosa en bebidas y productos alimenticios diteticos o de calorias reducidas.
MXPA03009996A (es) 2001-05-01 2004-05-27 Pepsico Inc Uso de eritritol y d-tagatosa en bebidas y productos alimenticios de cero o bajas calorias.
RU2198548C1 (ru) 2001-06-01 2003-02-20 Общество с ограниченной ответственностью Научно-производственное холдинговое объединение "СТЕВИЯ-АГРОМЕДФАРМ" Способ получения экстракта из растения stevia rebaudiana bertoni
CN1132840C (zh) 2001-10-24 2003-12-31 青岛创升生物科技有限公司 甜菊糖甙的精制方法
CN1330770C (zh) 2002-02-14 2007-08-08 诺维信公司 淀粉加工方法
SE0200539D0 (sv) 2002-02-25 2002-02-25 Metcon Medicin Ab Granulation process and starch granulate
KR101153459B1 (ko) 2002-06-12 2012-06-07 더 코카콜라 컴파니 식물성 스테롤을 함유하는 음료
CN1237182C (zh) 2002-06-25 2006-01-18 山东华仙甜菊股份有限公司 一种甜菊糖味质的改善方法
WO2004081022A2 (en) 2003-03-10 2004-09-23 Genencor International Inc. Grain compositions containing pre-biotic isomalto-oligosaccharides and methods of making and using same
BRPI0507583A (pt) 2004-03-17 2007-07-03 Cargill Inc adoçantes com baixo ìndice glicêmico e produtos feitos usando os mesmos
US7476248B2 (en) 2004-04-06 2009-01-13 Alcon, Inc. Method of calculating the required lens power for an opthalmic implant
US7923552B2 (en) 2004-10-18 2011-04-12 SGF Holdings, LLC High yield method of producing pure rebaudioside A
US7838044B2 (en) 2004-12-21 2010-11-23 Purecircle Sdn Bhd Extraction, separation and modification of sweet glycosides from the Stevia rebaudiana plant
US20060142555A1 (en) 2004-12-23 2006-06-29 Council Of Scientific And Industrial Research Process for production of steviosides from stevia rebaudiana bertoni
WO2006072878A1 (en) 2005-01-07 2006-07-13 Ranbaxy Laboratories Limited Oral dosage forms of sertraline having controlled particle size and processes for their preparation
WO2006072879A1 (en) 2005-01-07 2006-07-13 Ranbaxy Laboratories Limited Preparation of sweetener tablets of stevia extract by dry granulation methods
US7838011B2 (en) 2005-02-14 2010-11-23 Pankaj Modi Stabilized protein compositions for topical administration and methods of making same
US7807206B2 (en) 2005-10-11 2010-10-05 Purecircle Sdn Bhd Sweetner and use
US9392799B2 (en) * 2011-02-17 2016-07-19 Purecircle Sdn Bhd Glucosyl stevia composition
US7862845B2 (en) 2005-10-11 2011-01-04 Purecircle Sdn Bhd Process for manufacturing a sweetener and use thereof
US8334006B2 (en) 2005-10-11 2012-12-18 Purecircle Sdn Bhd Process for manufacturing a sweetener and use thereof
US9107436B2 (en) 2011-02-17 2015-08-18 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US8790730B2 (en) 2005-10-11 2014-07-29 Purecircle Usa Process for manufacturing a sweetener and use thereof
US8318459B2 (en) 2011-02-17 2012-11-27 Purecircle Usa Glucosyl stevia composition
US8337927B2 (en) 2005-10-11 2012-12-25 Purecircle Sdn Bhd Process for manufacturing a sweetener and use thereof
US8318232B2 (en) 2005-10-11 2012-11-27 Purecircle Sdn Bhd Sweetner and use
US8257948B1 (en) 2011-02-17 2012-09-04 Purecircle Usa Method of preparing alpha-glucosyl Stevia composition
US8323716B2 (en) 2005-10-11 2012-12-04 Purecircle Sdn Bhd Sweetner and use
US9386797B2 (en) * 2011-02-17 2016-07-12 Purecircle Sdn Bhd Glucosyl stevia composition
US8956677B2 (en) 2005-11-23 2015-02-17 The Coca-Cola Company High-potency sweetener composition with glucosamine and compositions sweetened therewith
US8993027B2 (en) 2005-11-23 2015-03-31 The Coca-Cola Company Natural high-potency tabletop sweetener compositions with improved temporal and/or flavor profile, methods for their formulation, and uses
US8524303B2 (en) 2005-11-23 2013-09-03 The Coca-Cola Company High-potency sweetener composition with phytosterol and compositions sweetened therewith
US8945652B2 (en) 2005-11-23 2015-02-03 The Coca-Cola Company High-potency sweetener for weight management and compositions sweetened therewith
US8524304B2 (en) 2005-11-23 2013-09-03 The Coca-Cola Company High-potency sweetener composition with probiotics/prebiotics and compositions sweetened therewith
US20070116825A1 (en) 2005-11-23 2007-05-24 The Coca-Cola Company Confection with High-Potency Sweetener
US8956678B2 (en) 2005-11-23 2015-02-17 The Coca-Cola Company High-potency sweetener composition with preservative and compositions sweetened therewith
US20070116839A1 (en) 2005-11-23 2007-05-24 The Coca-Cola Company High-Potency Sweetener Composition With C-Reactive Protein Reducing Substance and Compositions Sweetened Therewith
US20070116800A1 (en) 2005-11-23 2007-05-24 The Coca-Cola Company Chewing Gum with High-Potency Sweetener
US20070116833A1 (en) 2005-11-23 2007-05-24 The Coca-Cola Company High-Potency Sweetener Composition with Calcium and Compositions Sweetened Therewith
US20070116820A1 (en) 2005-11-23 2007-05-24 The Coca-Cola Company Edible gel compositions comprising high-potency sweeteners
US20070116822A1 (en) 2005-11-23 2007-05-24 The Coca-Cola Company High-potency sweetener composition with saponin and compositions sweetened therewith
US8940351B2 (en) 2005-11-23 2015-01-27 The Coca-Cola Company Baked goods comprising high-potency sweetener
US8435587B2 (en) 2005-11-23 2013-05-07 The Coca-Cola Company High-potency sweetener composition with long-chain primary aliphatic saturated alcohol and compositions sweetened therewith
BRPI0618945A2 (pt) 2005-11-23 2011-09-27 Coca Cola Co composição adoçante, método para conferir um perfil temporal mais parecido com o do açúcar, um perfil de flavor mais parecido com o do açúcar ou ambos a um adoçante de alta potência natural, composição adoçada, e, método para conferir um perfil temporal mais parecido com o do açúcar, um perfil de flavor ou ambos a uma composição adoçada de alta potência natural
US8512789B2 (en) 2005-11-23 2013-08-20 The Coca-Cola Company High-potency sweetener composition with dietary fiber and compositions sweetened therewith
US20070116831A1 (en) 2005-11-23 2007-05-24 The Coca-Cola Company Dental Composition with High-Potency Sweetener
US20070134391A1 (en) 2005-11-23 2007-06-14 The Coca-Cola Company High-Potency Sweetener Composition for Treatment and/or Prevention of Autoimmune Disorders and Compositions Sweetened Therewith
US20070116829A1 (en) 2005-11-23 2007-05-24 The Coca-Cola Company Pharmaceutical Composition with High-Potency Sweetener
US9144251B2 (en) 2005-11-23 2015-09-29 The Coca-Cola Company High-potency sweetener composition with mineral and compositions sweetened therewith
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8962058B2 (en) 2005-11-23 2015-02-24 The Coca-Cola Company High-potency sweetener composition with antioxidant and compositions sweetened therewith
US8367138B2 (en) 2005-11-23 2013-02-05 The Coca-Cola Company Dairy composition with high-potency sweetener
US8367137B2 (en) 2005-11-23 2013-02-05 The Coca-Cola Company High-potency sweetener composition with fatty acid and compositions sweetened therewith
US8435588B2 (en) 2005-11-23 2013-05-07 The Coca-Cola Company High-potency sweetener composition with an anti-inflammatory agent and compositions sweetened therewith
US8940350B2 (en) 2005-11-23 2015-01-27 The Coca-Cola Company Cereal compositions comprising high-potency sweeteners
US20070116836A1 (en) 2005-11-23 2007-05-24 The Coca-Cola Company High-Potency Sweetener Composition for Treatment and/or Prevention of Osteoporosis and Compositions Sweetened Therewith
US8377491B2 (en) 2005-11-23 2013-02-19 The Coca-Cola Company High-potency sweetener composition with vitamin and compositions sweetened therewith
US20070116823A1 (en) 2005-11-23 2007-05-24 The Coca-Cola Company High-potency sweetener for hydration and sweetened hydration composition
US7927851B2 (en) 2006-03-21 2011-04-19 Vineland Research And Innovation Centre Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same
US9012626B2 (en) 2006-06-19 2015-04-21 The Coca-Cola Company Rebaudioside a composition and method for purifying rebaudioside a
US8791253B2 (en) 2006-06-19 2014-07-29 The Coca-Cola Company Rebaudioside A composition and method for purifying rebaudioside A
DK2049673T3 (da) 2006-08-11 2011-07-04 Danisco Us Inc Native kornamylaser i enzymkombinationer til hydrolyse af granulær stivelse
KR101374980B1 (ko) 2006-09-20 2014-03-14 가부시키가이샤 유야마 세이사쿠쇼 약제 포장 장치
FR2906712A1 (fr) 2006-10-09 2008-04-11 France Chirurgie Instr Bouchon meatique a pose simplifiee.
FR2906973B1 (fr) 2006-10-17 2009-01-16 Roquette Freres Composition edulcorante granulee
US20080102497A1 (en) 2006-10-31 2008-05-01 Dominic Wong Enzymatic hydrolysis of starch
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US9101161B2 (en) 2006-11-02 2015-08-11 The Coca-Cola Company High-potency sweetener composition with phytoestrogen and compositions sweetened therewith
US20080107787A1 (en) 2006-11-02 2008-05-08 The Coca-Cola Company Anti-Diabetic Composition with High-Potency Sweetener
FI20070521L (fi) 2006-11-10 2008-05-11 Atacama Labs Oy Rakeita, tabletteja ja rakeistusmenetelmä
CN101200480B (zh) 2006-12-15 2011-03-30 成都华高药业有限公司 莱鲍迪甙a的提取方法
AU2008209573B2 (en) 2007-01-22 2013-08-22 Cargill, Incorporated Method of producing purified rebaudioside A compositions using solvent/antisolvent crystallization
US20080226773A1 (en) 2007-03-14 2008-09-18 Concentrate Manufacturing Company Of Ireland Beverage Sweetened with Rebaudioside A
US8029846B2 (en) 2007-03-14 2011-10-04 The Concentrate Manufacturing Company Of Ireland Beverage products
US9877500B2 (en) 2007-03-14 2018-01-30 Concentrate Manufacturing Company Of Ireland Natural beverage products
US8277862B2 (en) 2007-03-14 2012-10-02 Concentrate Manufacturing Company Of Ireland Beverage products having steviol glycosides and at least one acid
KR101540230B1 (ko) 2007-04-26 2015-07-29 가부시기가이샤하야시바라 분기 α-글루칸, 이를 생성하는 α-글루코실 전이 효소, 및 그의 제조 방법 및 용도
US8030481B2 (en) 2007-05-21 2011-10-04 The Coca-Cola Company Stevioside polymorphic and amorphous forms, methods for their formulation, and uses
US20080292765A1 (en) 2007-05-22 2008-11-27 The Coca-Cola Company Sweetness Enhancers, Sweetness Enhanced Sweetener Compositions, Methods for Their Formulation, and Uses
US20080292775A1 (en) 2007-05-22 2008-11-27 The Coca-Cola Company Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses
MX2010000193A (es) 2007-06-29 2010-05-14 Mcneil Nutritionals Llc Edulcorantes de mesa que contienen stevia y metodos de produccion de estos.
US7964232B2 (en) 2007-09-17 2011-06-21 Pepsico, Inc. Steviol glycoside isomers
US20090104330A1 (en) 2007-10-19 2009-04-23 Mccormick & Company, Inc. Reduced sodium salty taste composition, process for its preparation and food systems containing such composition
WO2009071277A1 (en) 2007-12-03 2009-06-11 Dsm Ip Assets B.V. Novel nutraceutical compositions containing stevia extract or stevia extract constituents and uses thereof
US20090162499A1 (en) 2007-12-21 2009-06-25 The Quaker Oats Company Grain products having a potent natural sweetener and a bulking agent
TWI475963B (zh) 2008-02-25 2015-03-11 Coca Cola Co 甜菊糖苷ａ衍生性產物以及製造彼的方法
FR2929533B1 (fr) 2008-04-03 2010-04-30 Novasep Procede de separation multicolonnes a gradient.
CA2758122C (en) 2008-04-11 2017-05-16 Zhijun Liu Diterpene glycosides as natural solubilizers
US9005444B2 (en) 2008-05-13 2015-04-14 Cargill, Incorporated Separation of rebaudioside A from stevia glycosides using chromatography
US8321670B2 (en) 2008-07-11 2012-11-27 Bridgewater Systems Corp. Securing dynamic authorization messages
KR101345172B1 (ko) 2008-07-18 2013-12-27 엘지디스플레이 주식회사 전기영동 표시소자
EP2416670A4 (en) 2009-04-09 2014-05-21 Cargill Inc SWEET COMPOSITION WITH REBAUDIOSIDE A HIGH SOLUBILITY FORM AND MANUFACTURING PROCESS
ES2523997T3 (es) 2009-06-16 2014-12-03 Epc (Beijing) Natural Products Co., Ltd. Reducción o eliminación del sabor residual en un edulcorante utilizando rebaudiósido D
CN101591365B (zh) 2009-07-07 2011-12-28 天津美伦医药集团有限公司 分离高纯度甜菊糖甙stv的工艺
CN101628924B (zh) 2009-08-21 2011-12-28 天津美伦医药集团有限公司 甜菊糖甙中瑞鲍迪甙c的提取工艺
US8524785B2 (en) 2009-09-04 2013-09-03 International Flavors And Fragrances Inc. Methods for using rebaudioside C as a flavor enhancer
MX2012003686A (es) 2009-10-15 2012-07-25 Purecircle Sdn Bhd Rebaudiosido d de alta pureza y aplicaciones.
US8299224B2 (en) 2009-10-15 2012-10-30 Purecircle Sdn Bhd High-purity Rebaudioside D
US8703224B2 (en) 2009-11-04 2014-04-22 Pepsico, Inc. Method to improve water solubility of Rebaudioside D
US20110111115A1 (en) 2009-11-06 2011-05-12 Jingang Shi Rebaudioside a polymorphs and methods to prepare them
WO2011059954A1 (en) 2009-11-12 2011-05-19 Purecircle Usa Granulation of a stevia sweetener
US20110189360A1 (en) 2010-02-04 2011-08-04 Pepsico, Inc. Method to Increase Solubility Limit of Rebaudioside D in an Aqueous Solution
EP4108668A1 (en) * 2010-03-12 2022-12-28 PureCircle USA Inc. High-purity steviol glycosides
US10696706B2 (en) 2010-03-12 2020-06-30 Purecircle Usa Inc. Methods of preparing steviol glycosides and uses of the same
EP2547221B1 (en) 2010-03-13 2014-12-17 Eastpond Laboratories Limited Fat-binding compositions
MX349121B (es) 2010-06-02 2017-07-12 Evolva Inc Produccion recombinante de esteviol glucosidos.
WO2012006728A1 (en) 2010-07-15 2012-01-19 Glg Life Tech Corporation Sweetener compositions and methods of making same
EP2645847B1 (en) 2010-11-30 2018-01-17 Massachusetts Institute of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
US9090647B2 (en) 2010-12-13 2015-07-28 Cargill, Incorporated Crystalline forms of rebaudioside B
JP6290624B2 (ja) 2010-12-13 2018-03-07 カーギル・インコーポレイテッド 配糖体混合物
US8894846B2 (en) 2010-12-23 2014-11-25 Stephen Lee Yarbro Using supercritical fluids to refine hydrocarbons
MY162807A (en) 2010-12-24 2017-07-14 Daicel Corp Acetic acid production method
CA2857080A1 (en) 2010-12-29 2012-07-05 Glg Life Tech Corporation Sweetener compositions and methods of making same
WO2012088612A1 (en) 2010-12-31 2012-07-05 Glg Life Tech Corporation High rebaudioside-a plant and methods of producing the same and uses thereof
EP2667732B1 (en) 2011-01-28 2015-07-29 Tate & Lyle Ingredients Americas LLC Stevia blends containing rebaudioside b
US9603373B2 (en) 2011-02-17 2017-03-28 Purecircle Sdn Bhd Glucosyl stevia composition
US9795156B2 (en) 2011-03-17 2017-10-24 E.P.C (Beijing) Plant Pharmaceutical Technology Co., Ltd Rebaudioside B and derivatives
BR112013023831A2 (pt) 2011-03-22 2020-09-29 Purecircle Usa Inc. composição de glicosídeo de esteviol glicosilado como um intensificador de sabor e aroma
BR112013030701B1 (pt) 2011-05-31 2021-07-20 Purecircle Usa Inc Processo para produzir uma composição de estévia compreendendo rebaudiosídeo b, a qual pode ser utilizada como intensificador de adoçante, um intensificador de sabor e/ou um adoçante
EP3101024A1 (en) 2011-06-03 2016-12-07 Purecircle USA Stevia compostion comprising rebaudioside a or d with rebaudioside b
EP2720561B1 (en) 2011-06-20 2018-11-14 PureCircle USA Inc. Stevia composition
US20150230508A1 (en) * 2011-06-20 2015-08-20 Siddhartha PURKAYASTHA Stevia composition
WO2013022989A2 (en) 2011-08-08 2013-02-14 Evolva Sa Recombinant production of steviol glycosides
WO2013036767A1 (en) 2011-09-09 2013-03-14 The Coca-Cola Company Improved natural sweetened compositions and methods for preparing the same
CN103159808B (zh) * 2011-12-09 2017-03-29 上海泓博智源医药股份有限公司 一种制备天然甜味剂的工艺方法
PL3009010T3 (pl) 2011-12-19 2020-10-19 Purecircle Sdn Bhd Sposoby oczyszczania glikozydów stewiolowych
CN104203005A (zh) 2012-01-23 2014-12-10 帝斯曼知识产权资产管理有限公司 二萜的生产
US9752174B2 (en) 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
JP6346174B2 (ja) * 2012-05-22 2018-06-20 ピュアサークル スンディリアン ブルハド 高純度ステビオールグリコシド
GB201217700D0 (en) * 2012-08-01 2012-11-14 Tate & Lyle Ingredients Sweetener compositions containing rebaudioside B
CN103564381A (zh) * 2012-08-03 2014-02-12 成都华高瑞甜科技有限公司 复合甜味剂和制法、及改善果葡糖浆口感的方法
JP6192283B2 (ja) 2012-10-11 2017-09-06 スリーエム イノベイティブ プロパティズ カンパニー ファスナ部材
EP2928321A1 (en) * 2012-12-05 2015-10-14 Evolva SA Steviol glycoside compositions sensory properties
WO2014122328A1 (en) 2013-02-11 2014-08-14 Evolva Sa Efficient production of steviol glycosides in recombinant hosts
US9717267B2 (en) 2013-03-14 2017-08-01 The Coca-Cola Company Beverages containing rare sugars
US10683323B2 (en) 2013-03-15 2020-06-16 The Coca-Cola Company Mogrosides, compositions and their purification
CN105283464B (zh) 2013-03-15 2018-02-13 可口可乐公司 甜菊醇糖苷、其组合物以及其纯化
JP2016527905A (ja) 2013-08-15 2016-09-15 カーギル・インコーポレイテッド レバウドシドｎを組み込む甘味料及び甘味を付与した組成物
US20150223505A1 (en) * 2014-02-12 2015-08-13 Purecircle Usa Inc. Stevia composition, production method and uses
CA2939784C (en) * 2014-02-18 2023-01-24 Mcneil Nutritionals, Llc Process for separation, isolation and characterization of steviol glycosides
US10815261B2 (en) 2014-04-02 2020-10-27 Purecircle Sdn Bhd Compounds produced from stevia and process for producing the same
CN104151378A (zh) 2014-08-12 2014-11-19 济南汉定生物工程有限公司 一种甜菊糖甙rm的提纯方法
BR112017004240B1 (pt) * 2014-09-02 2022-04-05 The Coca-Cola Company Processo para preparar uma composição de glicosídeo de esteviol aquoso não tratado, extrato de stevia aquoso não tratado preparado pelo referido processo e alimento ou bebida
JP6855376B2 (ja) 2014-12-17 2021-04-07 カーギル インコーポレイテッド 経口摂取又は経口使用のためのステビオールグリコシド化合物、組成物、及びステビオールグリコシド溶解度を増強するための方法
CA2979166C (en) * 2015-03-11 2024-01-09 Morita Kagaku Kogyo Co., Ltd. Sweetener composition and food containing same
WO2016187559A1 (en) * 2015-05-20 2016-11-24 Cargill, Incorporated Glycoside compositions
EP3337340B1 (en) * 2015-08-18 2021-10-06 Purecircle Usa Inc. Steviol glycoside solutions
EP3766362B1 (en) 2015-10-02 2022-12-28 The Coca-Cola Company Method of production of steviol glycoside sweeteners with improved flavor profiles
MX2018011075A (es) 2016-03-14 2019-07-04 Purecircle Usa Inc Glicosidos de esteviol altamente solubles.
WO2019117315A1 (ja) 2017-12-15 2019-06-20 日本電気株式会社 セルロース系樹脂組成物、成形体及びこれを用いた製品、並びにセルロース系樹脂組成物の製造方法
JP7177862B2 (ja) 2021-01-04 2022-11-24 本田技研工業株式会社 位置決定装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101742924A (zh) * 2007-05-22 2010-06-16 可口可乐公司 具有增强的甜味和改进的时间和/或风味概况的增甜剂组合物
CN102216313A (zh) * 2008-10-03 2011-10-12 守田化学工业株式会社 新的甜菊醇糖苷
CN102894325A (zh) * 2011-07-25 2013-01-30 成都华高瑞甜科技有限公司 复合甜味剂和制法、及改善甜菊糖苷类甜味剂口感的方法
WO2014122227A2 (en) * 2013-02-06 2014-08-14 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
WO2014197898A1 (en) * 2013-06-07 2014-12-11 Purecircle Usa Inc. Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108712864A (zh) * 2015-12-15 2018-10-26 谱赛科美国股份有限公司 甜菊醇糖苷组合物
CN109349596A (zh) * 2018-09-29 2019-02-19 四川盈嘉合生科技有限公司 甜味剂组合物

Also Published As

Publication number Publication date
BR122020008481B1 (pt) 2022-10-18
ES2970118T3 (es) 2024-05-27
EP3367816B1 (en) 2023-12-06
PL3367816T3 (pl) 2024-05-06
CN115336734A (zh) 2022-11-15
WO2017075034A1 (en) 2017-05-04
US11647771B2 (en) 2023-05-16
MX2018005148A (es) 2018-08-01
EP3367816A1 (en) 2018-09-05
CN115299547A (zh) 2022-11-08
EP4275516A2 (en) 2023-11-15
EP3367816C0 (en) 2023-12-06
MX2023004432A (es) 2023-05-08
RU2731068C2 (ru) 2020-08-28
BR112018008489B1 (pt) 2023-03-14
EP4275516A3 (en) 2024-01-24
EP3367816A4 (en) 2019-05-08
US20180317534A1 (en) 2018-11-08
RU2018119142A (ru) 2019-11-28
BR112018008489A2 (pt) 2018-10-23
US20230240345A1 (en) 2023-08-03
RU2018119142A3 (zh) 2020-02-12

Similar Documents

Publication Publication Date Title
CN108495559A (zh) 甜菊醇糖苷组合物
EP3766362B1 (en) Method of production of steviol glycoside sweeteners with improved flavor profiles
US9848632B2 (en) Steviol glycoside
JP6858116B2 (ja) 甘味料組成物、およびそれを含む食品
US20210095322A1 (en) High-purity steviol glycosides
DK3217813T3 (en) Composition comprising glycosylated steviol glycosides
CN110719738B (zh) 组合物
CN103153094B (zh) 基于甜叶菊的改进的甜化组合物和用其制备的可食用产品
JP2018509902A (ja) ステビオールグリコシドの酵素的修飾方法、それによって得られる修飾ステビオールグリコシド、およびそれらの甘味料としての使用
AU2019236279B2 (en) High-purity steviol glycosides
CN107105733A (zh) 甜叶菊成分、生产方法和用途
US11653686B2 (en) Steviol glycoside compositions
EP3906787A1 (en) Composition comprising transglycosylated stevioside and transglycosylated rebaudioside a
KR101914388B1 (ko) 감미질이 개선된 효소처리 스테비아 조성물이 함유된 감미료

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination