CN108348509A - 用于治疗增殖减少性病症的化合物 - Google Patents
用于治疗增殖减少性病症的化合物 Download PDFInfo
- Publication number
- CN108348509A CN108348509A CN201680063630.0A CN201680063630A CN108348509A CN 108348509 A CN108348509 A CN 108348509A CN 201680063630 A CN201680063630 A CN 201680063630A CN 108348509 A CN108348509 A CN 108348509A
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- China
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- alkyl
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- compound
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 C*(CCNC1)C[I-]1=[N+]=C=C Chemical compound C*(CCNC1)C[I-]1=[N+]=C=C 0.000 description 3
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE1551419-3 | 2015-11-03 | ||
SE1551419 | 2015-11-03 | ||
PCT/EP2016/076550 WO2017076968A1 (en) | 2015-11-03 | 2016-11-03 | Compounds for treatment of hypoproliferative disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108348509A true CN108348509A (zh) | 2018-07-31 |
Family
ID=57326350
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201680063630.0A Pending CN108348509A (zh) | 2015-11-03 | 2016-11-03 | 用于治疗增殖减少性病症的化合物 |
Country Status (11)
Country | Link |
---|---|
US (1) | US11471446B2 (pt) |
EP (1) | EP3370720A1 (pt) |
JP (1) | JP6977238B2 (pt) |
KR (1) | KR20180073600A (pt) |
CN (1) | CN108348509A (pt) |
AU (1) | AU2016348659B2 (pt) |
BR (1) | BR112018008931A8 (pt) |
CA (1) | CA3002495A1 (pt) |
IL (1) | IL258593B (pt) |
MX (1) | MX2018005158A (pt) |
WO (1) | WO2017076968A1 (pt) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023241627A1 (en) * | 2022-06-15 | 2023-12-21 | Insilico Medicine Ip Limited | Cdk8/19 dual inhibitors and methods of use thereof |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11014906B2 (en) | 2018-08-21 | 2021-05-25 | University Of South Carolina | Quinoline-based compounds and methods of inhibiting CDK8/19 |
AU2020216498A1 (en) | 2019-02-01 | 2021-09-23 | Senex Biotechnology, Inc | Bicyclic pyridine compositions and methods of using the same for cancer therapy |
WO2020237014A1 (en) * | 2019-05-21 | 2020-11-26 | University Of South Carolina | 3-amino-4-(4-(4 (dimethylcarbamoyl) phenyl)-1,4-diazepan-1-yl) thieno [2,3-b] pyridine-2-carboxamide for use in cancer therapy and formulations comprising the same |
GB202208226D0 (en) * | 2022-06-06 | 2022-07-20 | Royal Veterinary College | Method and treatment for osteoarthritis and diseases of chondrocyte hypertrophy |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1649581A (zh) * | 2002-06-06 | 2005-08-03 | 贝林格尔.英格海姆药物公司 | 取代的3-氨基-噻吩并[2,3-b]吡啶-2-羧酸酰胺化合物及其制备方法和用途 |
WO2013138101A2 (en) * | 2012-03-16 | 2013-09-19 | Children's Medical Center Corporation | Calmodulin inhibitors for the treatment of ribosomal disorders and ribosomapathies |
CN104363913A (zh) * | 2012-02-02 | 2015-02-18 | 申内克斯生物科技公司 | Cdk8/cdk19选择性抑制剂及其在癌症的抗转移和化学预防方法中的用途 |
CN104903321A (zh) * | 2012-11-08 | 2015-09-09 | 赛尔维他股份公司 | 作为激酶抑制剂的经取代三环苯并咪唑 |
WO2015144290A1 (en) * | 2014-03-27 | 2015-10-01 | Merck Patent Gmbh | Pyridyl piperidines |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070219234A1 (en) | 2004-04-12 | 2007-09-20 | Kiyoshi Oizumi | Thienopyridine Derivatives |
US8598344B2 (en) | 2009-11-30 | 2013-12-03 | Senex Biotechnology | CDKI pathway inhibitors and uses thereof |
EA027531B1 (ru) * | 2011-09-13 | 2017-08-31 | Игорь Ронинсон | ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ И НАРУШЕНИЙ, ВЫЗВАННЫХ АКТИВНОСТЬЮ ТРАНСКРИПЦИОННОГО ФАКТОРА NF-κB |
MX2015002310A (es) | 2012-08-23 | 2015-06-05 | Hoffmann La Roche | Nuevas amidas de fenil-piridina/pirazina para el tratamiento de cancer. |
EP2928893A1 (en) | 2012-12-10 | 2015-10-14 | F. Hoffmann-La Roche AG | Novel bi-ring phenyl-pyridines/pyrazines for the treatment of cancer |
WO2014106606A1 (en) | 2013-01-05 | 2014-07-10 | F. Hoffmann-La Roche Ag | Nove phenyl/pyridine series substitued by hydroxyethylamino for the treatment of cancer |
WO2014154723A1 (en) | 2013-03-29 | 2014-10-02 | F. Hoffmann-La Roche Ag | Novel pyrrole derivatives for the treatment of cancer |
WO2014194201A2 (en) * | 2013-05-31 | 2014-12-04 | Nimbus Iris, Inc. | Cdk8 inhibitors and uses thereof |
-
2016
- 2016-11-03 CN CN201680063630.0A patent/CN108348509A/zh active Pending
- 2016-11-03 KR KR1020187013367A patent/KR20180073600A/ko unknown
- 2016-11-03 MX MX2018005158A patent/MX2018005158A/es unknown
- 2016-11-03 JP JP2018541543A patent/JP6977238B2/ja active Active
- 2016-11-03 EP EP16797472.4A patent/EP3370720A1/en not_active Withdrawn
- 2016-11-03 WO PCT/EP2016/076550 patent/WO2017076968A1/en active Application Filing
- 2016-11-03 AU AU2016348659A patent/AU2016348659B2/en active Active
- 2016-11-03 US US15/772,633 patent/US11471446B2/en active Active
- 2016-11-03 CA CA3002495A patent/CA3002495A1/en active Pending
- 2016-11-03 BR BR112018008931A patent/BR112018008931A8/pt active Search and Examination
-
2018
- 2018-04-10 IL IL258593A patent/IL258593B/en active IP Right Grant
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1649581A (zh) * | 2002-06-06 | 2005-08-03 | 贝林格尔.英格海姆药物公司 | 取代的3-氨基-噻吩并[2,3-b]吡啶-2-羧酸酰胺化合物及其制备方法和用途 |
CN104363913A (zh) * | 2012-02-02 | 2015-02-18 | 申内克斯生物科技公司 | Cdk8/cdk19选择性抑制剂及其在癌症的抗转移和化学预防方法中的用途 |
WO2013138101A2 (en) * | 2012-03-16 | 2013-09-19 | Children's Medical Center Corporation | Calmodulin inhibitors for the treatment of ribosomal disorders and ribosomapathies |
CN104903321A (zh) * | 2012-11-08 | 2015-09-09 | 赛尔维他股份公司 | 作为激酶抑制剂的经取代三环苯并咪唑 |
WO2015144290A1 (en) * | 2014-03-27 | 2015-10-01 | Merck Patent Gmbh | Pyridyl piperidines |
Non-Patent Citations (2)
Title |
---|
SHENG WEI ET AL.: "Lenalidomide Promotes p53 Degradation by Inhibiting MDM2 Auto-ubiquitination in Myelodysplastic Syndrome with Chromosome 5q Deletion", 《ONCOGENE》 * |
STEFANO FUMAGALLI ET AL.: "The Role of p53 in Ribosomopathies", 《SEMINARS IN HEMATOLOGY》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023241627A1 (en) * | 2022-06-15 | 2023-12-21 | Insilico Medicine Ip Limited | Cdk8/19 dual inhibitors and methods of use thereof |
Also Published As
Publication number | Publication date |
---|---|
US11471446B2 (en) | 2022-10-18 |
BR112018008931A2 (pt) | 2018-11-06 |
IL258593A (en) | 2018-06-28 |
IL258593B (en) | 2021-04-29 |
KR20180073600A (ko) | 2018-07-02 |
EP3370720A1 (en) | 2018-09-12 |
AU2016348659B2 (en) | 2022-07-28 |
CA3002495A1 (en) | 2017-05-11 |
WO2017076968A1 (en) | 2017-05-11 |
JP2018532784A (ja) | 2018-11-08 |
US20190111034A1 (en) | 2019-04-18 |
JP6977238B2 (ja) | 2021-12-08 |
AU2016348659A1 (en) | 2018-05-31 |
BR112018008931A8 (pt) | 2019-02-26 |
MX2018005158A (es) | 2019-05-16 |
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PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
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WD01 | Invention patent application deemed withdrawn after publication | ||
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Application publication date: 20180731 |