WO2018096525A2

WO2018096525A2 - Heteroaryl compounds and uses thereof

Info

Publication number: WO2018096525A2
Application number: PCT/IB2018/052089
Authority: WO
Inventors: Peter Anthony CICALA
Original assignee: Celgene Corporation
Priority date: 2018-03-27
Filing date: 2018-03-27
Publication date: 2018-05-31
Also published as: WO2018096525A3

Abstract

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

Description

HETEROARYL COMPOUNDS AND USES THEREOF

FIELD OF THE INVENTION

[0001] The present invention provides compounds, and compositions thereof, useful as inhibitors of protein kinases.

BACKGROUND OF THE INVENTION

[0002] The search for new therapeutic agents has been greatly aided in recent years by a better understanding of the structure of enzymes and other biomolecules associated with diseases. One important class of enzymes that has been the subject of extensive study is protein kinases.

[0003] Protein kinases constitute a large family of structurally related enzymes that are responsible for the control of a variety of signal transduction processes within the cell. Protein kinases are thought to have evolved from a common ancestral gene due to the conservation of their structure and catalytic function. Almost all kinases contain a similar 250-300 amino acid catalytic domain. The kinases may be categorized into families by the substrates they phosphorylate (e.g., protein-tyrosine, protein-serine/threonine, lipids, etc.).

[0004] In general, protein kinases mediate intracellular signaling by effecting a phosphoryl transfer from a nucleoside triphosphate to a protein acceptor that is involved in a signaling pathway. These phosphorylation events act as molecular on/off switches that can modulate or regulate the target protein biological function. These phosphorylation events are ultimately triggered in response to a variety of extracellular and other stimuli. Examples of such stimuli include environmental and chemical stress signals (e.g., osmotic shock, heat shock, ultraviolet radiation, bacterial endotoxin, and H₂O₂), cytokines (e.g., interleukin-1 (IL-1) and tumor necrosis factor a (TNF-a)), and growth factors (e.g., granulocyte macrophage-colony-stimulating factor (GM-CSF), and fibroblast growth factor (FGF)). An extracellular stimulus may affect one or more cellular responses related to cell growth, migration, differentiation, secretion of hormones, activation of transcription factors, muscle contraction, glucose metabolism, control of protein synthesis, and regulation of the cell cycle. [0005] Many diseases are associated with abnormal cellular responses triggered by protein kinase-mediated events as described above. These diseases include, but are not limited to, autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies and asthma, Alzheimer's disease, and hormone-related diseases. Accordingly, there remains a need to find protein kinase inhibitors useful as therapeutic agents.

SUMMARY OF THE I VENTION

[0006] It has now been found that compounds of the present invention, and compositions thereof, are useful as inhibitors of one or more protein kinases and exhibit desirable characteristics for the same. Such compounds have general Formula I:

I or a pharmaceutically acceptable salt thereof, wherein each of R¹, R², R³, R⁴, R⁴ , R⁴ , R⁵, R⁶, R⁶,

R⁷, R^7', R^8a, R^8a', R⁸ , R^{8 '}, R^9a, R^9a', R⁹ , R^{9 '}, R^xa, R^x , R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is as defined herein.

[0007] Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful for treating a variety of diseases, disorders or conditions, associated with abnormal cellular responses triggered by protein kinase-mediated events. Such diseases, disorders, or conditions include those described herein.

[0008] Compounds provided by this invention are also useful for the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.

DETAILED DESCRIPTION OF THE INVENTION

1. General Description of Certain Aspects of the Invention

[0009] As described above, the present invention provides certain compounds, and compositions thereof, useful as protein kinase inhibitors. In particular, the present invention provides certain 2,4-disubstituted pyrimidine compounds which inhibit activity of one or more protein kinases, including Janus kinase ("JAK"). Such compounds have the structure of Formula I:

I or a harmaceutically acceptable salt thereof, wherein:

each of R^la, R^l , R^lc, R^2a, R² , R^2c, R^3a, R³ , R^3c, R⁴, R^4', R^4", R⁵, R⁶, R^6', R⁷, R^7', R^8a, R^8a', R⁸ ,

R^{8 '}, R^9a, R^9a', R⁹ , R^{9 '}, R^xa, R^x , R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is independently selected from hydrogen or deuterium;

provided that at least one of R^la, R^l , R^lc, R^2a, R² , R^2c, R^3a, R³ , R^3c, R⁴, R^4', R^4", R⁵, R⁶, R^6',

R⁷, R^7', R^8a, R^8a', R⁸ , R^{8 '}, R^9a, R^9a', R⁹ , R^{9 '}, R^xa, R^x , R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is deuterium.

[0010] In some embodiments, the present invention provides a compound of Formula I, wherein the compound is a co

2. Compounds and Definitions

[0011] Compounds of this invention include those described generally above, and are further illustrated by the classes, subclasses, and species disclosed herein. As used herein, the following definitions shall apply unless otherwise indicated. For purposes of this invention, the chemical elements are identified in accordance with the Periodic Table of the Elements, CAS version, Handbook of Chemistry and Physics, 75^th Ed. Additionally, general principles of organic chemistry are described in "Organic Chemistry", Thomas Sorrell, University Science Books, Sausalito: 1999, and "March's Advanced Organic Chemistry", 5^th Ed., Ed.: Smith, M.B. and March, J., John Wiley & Sons, New York: 2001, the entire contents of which are hereby incorporated by reference.

[0012] As used herein, the term "pharmaceutically acceptable salt" refers to those salts which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response and the like, and are commensurate with a reasonable benefit/risk ratio. Pharmaceutically acceptable salts are well known in the art. For example, S. M. Berge et al., describe pharmaceutically acceptable salts in detail in J. Pharmaceutical Sciences, 1977, 66, 1-19, incorporated herein by reference. Pharmaceutically acceptable salts of the compounds of this invention include those derived from suitable inorganic and organic acids and bases. Examples of pharmaceutically acceptable, nontoxic acid addition salts are salts of an amino group formed with inorganic acids such as hydrochloric acid, hydrobromic acid, phosphoric acid, sulfuric acid and perchloric acid or with organic acids such as acetic acid, oxalic acid, maleic acid, tartaric acid, citric acid, succinic acid or malonic acid or by using other methods used in the art such as ion exchange. Other pharmaceutically acceptable salts include adipate, alginate, ascorbate, aspartate, benzenesulfonate, benzoate, bisulfate, borate, butyrate, camphorate, camphorsulfonate, citrate, cyclopentanepropionate, digluconate, dodecylsulfate, ethanesulfonate, formate, fumarate, glucoheptonate, glycerophosphate, gluconate, hemisulfate, heptanoate, hexanoate, hydroiodide, 2-hydroxy-ethanesulfonate, lactobionate, lactate, laurate, lauryl sulfate, malate, maleate, malonate, methanesulfonate, 2-naphthalenesulfonate, nicotinate, nitrate, oleate, oxalate, palmitate, pamoate, pectinate, persulfate, 3-phenylpropionate, phosphate, pivalate, propionate, stearate, succinate, sulfate, tartrate, thiocyanate, p-toluenesulfonate, undecanoate, valerate salts, and the like.

[0013] Salts derived from appropriate bases include alkali metal, alkaline earth metal, ammonium and N⁺(Ci_₄alkyl)4 salts. Representative alkali or alkaline earth metal salts include sodium, lithium, potassium, calcium, magnesium, and the like. Further pharmaceutically acceptable salts include, when appropriate, nontoxic ammonium, quaternary ammonium, and amine cations formed using counterions such as halide, hydroxide, carboxylate, sulfate, phosphate, nitrate, loweralkyl sulfonate and aryl sulfonate.

[0014] Unless otherwise stated, structures depicted herein are also meant to include all isomeric (e.g., enantiomeric, diastereomeric, and geometric (or conformational)) forms of the structure; for example, the R and S configurations for each asymmetric center, Z and E double bond isomers, and Z and E conformational isomers. Therefore, single stereochemical isomers as well as enantiomeric, diastereomeric, and geometric (or conformational) mixtures of the present compounds are within the scope of the invention. Unless otherwise stated, all tautomeric forms of the compounds of the invention are within the scope of the invention.

[0015] As used herein, the term "inhibitor" is defined as a compound that binds to and /or inhibits the target protein kinase with measurable affinity. In certain embodiments, an inhibitor has an IC₅₀ and/or binding constant of less about 50 μΜ, less than about 1 μΜ, less than about 500 nM, less than about 100 nM, or less than about 10 nM.

[0016] The terms "measurable affinity" and "measurably inhibit," as used herein, means a measurable change in JAK activity between a sample comprising a compound of the present invention, or composition thereof, and an equivalent sample comprising JAK, in the absence of said compound, or composition thereof.

3. Description of Exemplary Compounds

[0017] Deuterium (D or ²H) is a stable, non-radioactive isotope of hydrogen and has an atomic weight of 2.0144. Hydrogen naturally occurs as a mixture of the isotopes 1H (hydrogen or protium), D (²H or deuterium), and T (³H or tritium). One skilled in the art appreciates that the designation "hydrogen" in hydrogen-containing chemical compounds actually represents a mixture of hydrogen and about 0.015% deuterium.

[0018] Complete deuteration, or 100% deuteration, at any one site can be difficult to achieve in the laboratory. When a deuterium atom is indicated at a given site on any compound described herein, it is understood that a small percentage of hydrogen may still be present. Such compounds are said to be enriched with deuterium. Deuterium-enriched compounds are prepared via synthesis utilizing appropriately enriched starting materials. As used herein, the terms "deuterium-enriched" or "deuterium enrichment" refer to a compound, or a particular site of said compound, which comprises deuterium in an amount that is greater than its natural isotopic abundance (0.015%). Accordingly, in some embodiments, the present invention provides compounds comprising deuterium at a given site, wherein the percentage or level of deuterium incorporation is greater than its natural isotopic abundance. [0019] According to one aspect, the present invention provides a compound of Formula I:

I or a harmaceutically acceptable salt thereof, wherein:

_R2a

-H^~R2B

R²is R^2c ;

each of R^la, R^l , R^lc, R^2a, R², R^2c, R^3a, R³ , R^3c, R⁴, R^4', R^4", R⁵, R⁶, R^6', R⁷, R^7', R^8a, R^8a', R⁸,

R^{8 '}, R^9a, R^9a', R⁹, R^{9 '}, R^xa, R^x, R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is independently selected from hydrogen or deuterium;

provided that at least one of R^la, R^l , R^lc, R^2a, R², R^2c, R^3a, R³ , R^3c, R⁴, R^4', R^4", R⁵, R⁶, R^6',

R⁷, R^7', R^8a, R^8a', R⁸, R^{8 '}, R^9a, R^9a', R⁹, R^{9 '}, R^xa, R^x, R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is deuterium.

[0020] In some embodiments, R^la is deuterium. In some embodiments, R^l is deuterium. In some embodiments, R^lc is deuterium. In some embodiments, each of R^la, R^l , and R^lc is deuterium. In some embodiments, each of R^la, R^l , and R^lc is deuterium and each of R^2a, R², T?2C ?3b ?3c ?4 ?4' ?4" ?5 T?6 ?6' ?7 TJV x?8a T?8a' ?8b ?8b' ?9a ?9a' ?9b ?9b' ?xa x_jxb

R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is hydrogen.

[0021] In some embodiments, R^2a is deuterium. In some embodiments, R² is deuterium. In some embodiments, R^2c is deuterium. In some embodiments, each of R^2a, R², and R^2c is deuterium. In some embodiments, each of R^2a, R², and R^2c is deuterium and each of R^la, R^l ,

Tjlc T?3a T_j3b ?3C ?4 ?4' ?4" T?5 ?6 ?6' ?7 TJV x?8a ?8a' ?8b ?8b' ?9a x_j9a' ?9b ?9b' ?xa x_jxb

R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is hydrogen.

[0022] In some embodiments, R^3a is deuterium. In some embodiments, R³ is deuterium. In some embodiments, R^3c is deuterium. In some embodiments, each of R^3a, R³ , and R^3c is deuterium. In some embodiments, each of R^3a, R³ , and R^3c is deuterium and each of R^la, R^l ,

TJIC T?2a T?2b T?2C T?4 TJ4' T?4" T?5 T?6 n& T?V TJV T?8a x_jSa' T?8b T?8b' T?9a τ?93' T?9b T?9b' x_jxa x_jxb

R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is hydrogen.

[0023] In some embodiments, each of R^la, R^l, R^lc, R^2a, R², R^2c, R^3a, R³, and R^3c is deuterium. In some embodiments, each of R^la, R^l , R^lc, R^2a, R², R^2c, R^3a, R³ , and R^3c is deuterium and each of R⁴, R^4', R^4", R⁵, R⁶, R^6', R⁷, R^7', R^8a, R^8a', R⁸, R^{8 '}, R^9a, R^9a', R⁹, R^{9 '}, R^xa, R^x, R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is hydrogen.

[0024] In some embodiments, R⁴ is deuterium. In some embodiments, R⁴ is deuterium. In some embodiments, R⁴ is deuterium. In some embodiments, each of each of R⁴, R⁴ , and R⁴ is deuterium and each of R^la, R^l , R^lc, R^2a, R², R^2c, R^3a, R³ , R^3c, R⁵, R⁶, R^6', R⁷, R^7', R^8a, R^8a', R⁸, R^{8 '}, R^9a, R^9a', R⁹, R^{9 '}, R^xa, R^x, R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is hydrogen.

[0025] In some embodiments, R⁵ is deuterium. In some embodiments, R⁵ is deuterium and each of R^la, R^l , R^lc, R^2a, R², R^2c, R^3a, R³, R^3c, R⁴, R^4', R^4", R⁶, R^6', R⁷, R^7', R^8a, R^8a', R⁸, R^{8 '}, R^9a, R^9a', R⁹, R^{9 '}, R^xa, R^x, R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is hydrogen.

[0026] In some embodiments, R⁶ is deuterium. In some embodiments, R⁶ is deuterium. In some embodiments, each of R⁶ and R⁶ is deuterium. In some embodiments, each of R⁶ and R⁶ is deuterium and each of R^la, R^l , R^lc, R^2a, R², R^2c, R^3a, R³ , R^3c, R⁴, R^4', R^4", R⁵, R⁷, R^7', R^8a, R^8a', R⁸, R^{8 '}, R^9a, R^9a', R⁹, R^{9 '}, R^xa, R^x, R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is hydrogen.

[0027] In some embodiments, R⁷ is deuterium. In some embodiments, R⁷ is deuterium. In

1 1' 1 1' some embodiments, each of R and R is deuterium. In some embodiments, each of R and R is deuterium and each of R^la, R^l , R^lc, R^2a, R², R^2c, R^3a, R³ , R^3c, R⁴, R^4', R^4", R⁵, R⁶, R^6', R^8a, R^8a', R⁸, R^{8 '}, R^9a, R^9a', R⁹, R^{9 '}, R^xa, R^x, R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is hydrogen. [0028] In some embodiments, R^8a is deuterium. In some embodiments, R^8a is deuterium. In some embodiments, R⁸ is deuterium. In some embodiments, R⁸ is deuterium. In some embodiments, each of R^8a and R^8a is deuterium. In some embodiments, each of R⁸ and R⁸ is deuterium. In some embodiments, each of R^8a, R^8a , R⁸, and R⁸ is deuterium and each of R^la,

x?2b T?2 T?3a x?3b T?3 T?4 T?4' T?4" ?5 T?6 T?6' T?7 V x?9a T?9a' x?9b T?9b' T?xa x_jxb

R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is hydrogen.

[0029] In some embodiments, R^9a is deuterium. In some embodiments, R^9a is deuterium. In some embodiments, R⁹ is deuterium. In some embodiments, R⁹ is deuterium. In some embodiments, each of R^9a and R^9a is deuterium. In some embodiments, each of R⁹ and R⁹ is deuterium. In some embodiments, each of R^9a, R^9a , R⁹, and R⁹ is deuterium and each of R^la, x_jlb ?lc ?2a ?2b ?2 ?3a ?3b ?3 ?4 4' ?4" ?5 ?6 6' ?7 V ?8a r_jSa' ?8b ?8b' x_jxa x_jxb

R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is hydrogen.

[0030] In some embodiments, R^xa is deuterium. In some embodiments, R^xa is deuterium and each of R^la, R^l, R^lc, R^2a, R², R^2c, R^3a, R³ , R^3c, R⁴, R^4', R^4", R⁵, R⁶, R^6', R⁷, R^7', R^8a, R^8a', R⁸, R^{8 '}, R^9a, R^9a', R⁹, R^{9 '}, R^x, R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is hydrogen.

[0031] In some embodiments, R^x is deuterium. In some embodiments, R^x is deuterium. In some embodiments, each of R^x and R^x is deuterium and each of R^la, R^l, R^lc, R^2a, R², R^2c, R^3a,

?y^a ?y^a'

R^y and R^y is hydrogen.

[0032] In some embodiments, R^xc is deuterium. In some embodiments, R^xc is deuterium and each of R^la, R^l, R^lc, R^2a, R², R^2c, R^3a, R³ , R^3c, R⁴, R^4', R^4", R⁵, R⁶, R^6', R⁷, R^7', R^8a, R^8a', R⁸, R^{8 '}, R^9a, R^9a', R⁹, R^{9 '}, R^xa, R^x, R^{x '}, R^ya, R^ya', R^y andR^{y '} is hydrogen.

[0033] In some embodiments, R^ya is deuterium. In some embodiments, R^ya is deuterium. In some embodiments, each of R^ya and R^ya' is deuterium and each of R^la, R^l, R^lc, R^2a, R², R^2c, R^3a, n b 3 4 4' T?4" 5 TJ6 TJ6' TJV V x_j8a r?9a x_j9a' x_jxa x_jxb r_jxb' , K

R^y, and R^y is hydrogen.

[0034] In some embodiments, R^y is deuterium. In some embodiments, R^y is deuterium. In some embodiments, each of R^y and R^{y '} is deuterium and each of R^la, R^l, R^lc, R^2a, R², R^2c, R^3a,

T?³ T?^3c ?8a xjSa' ?8b ?8b' ?9a τ?93' ?9b ?9b' xjxa xjxb xjxb'

R^ya, and R^ya' is hydrogen. [0035] In some embodiments of Formula I, each of R⁴, R⁴, R⁴ is hydrogen and each of R¹, R² and R³ is -C¾. Accordingly, in some embodiments, the present invention provides a compound of Formula Il-a:

II-a

or a pharmaceutically acceptable salt thereof, wherein:

each of R⁶, R^6', R⁷, R^7', R^8a, R^8a', R⁸ , R^{8 '}, R^9a, R^9a', R⁹ , R^{9 '}, R^xa, R^x, R^{x '}, R^xc, R^ya, R^ya', R^y and R^y is independently selected from hydrogen or deuterium;

provided that at least one of R⁶, R^6', R⁷, R^7', R^8a, R^8a', R⁸ , R^{8 '}, R^9a, R^9a', R⁹, R^{9 '}, R^xa, R^x, R^{x '}, R^xc, R^ya, R^ya', R^y andR^{y '} is deuterium.

[0036] In some embodiments of Formula I, each of R⁴, R⁴, R⁴ is hydrogen and each of R¹, R² and R³ is -CH₃. Accordingly, in some embodiments, the present invention provides a compound of Formula Ill-a:

III-a

or a pharmaceutically acceptable salt thereof, wherein:

each of R⁶, R^6', R⁷, R^7', R^8a, R^8a', R⁸ , R^{8 '}, R^9a, R^9a', R⁹ , R^{9 '}, R^xa, R^x , R^{x '}, R^xc, R^ya, R^ya', R^y and R^y is independently selected from hydrogen or deuterium.

[0037] In some embodiments of Formula I, each of R⁴, R⁴ , R⁴ is hydrogen and each of R¹, R² and R³ is -CD₃. Accordingly, in some embodiments, the present invention provides a compound of Formula Il-b or Formula Ill-b:

Il-b or a pharmaceutically acceptable salt thereof, wherein:

[0038] In some embodiments of Formula I, each of R⁴, R⁴, R⁴ is deuterium and each of R¹, R² and R³ is -C¾. Accordingly, in some embodiments, the present invention provides a compound of Formula II-c or Formula III-c:

or a pharmaceutically acceptable salt thereof, wherein:

[0039] In some embodiments of Formula I, each of R⁴, R⁴, R⁴ is deuterium and each of R¹, R² and R³ is -CD₃. Accordingly, in some embodiments, the present invention provides a compound of Formula Il-d or Formula Ill-d:

II-d III-d

or a pharmaceutically acceptable salt thereof, wherein

each of R⁶⁶,, R⁶', R⁷ R⁷', R^8a, R^8a', R⁸ , R⁸ ', R^9a, R^9a', R⁹ , R⁹ ', R^xa, R^x , R^x ', R^xc, R^ya, R^ya', R^y and R^y is independently selected from hydrogen or deuterium

[0040] Table 1 sets forth compounds of Formula Il-a, Il-b, II-c, and II-d wherein each of R⁶, R⁶ , R⁷ and R⁷ is hydrogen. Table 2 sets forth compounds of Formula Il-a, Il-b, II-c, and Π- d wherein each of R⁶ and R⁶ is hydrogen and each of R⁷ and R⁷ is deuterium. Table 3 sets forth compounds of Formula Il-a, Il-b, II-c, and II-d wherein each of R⁶ and R⁶ is deuterium and each of R⁷ and R⁷ is hydrogen. Table 4 sets forth compounds of Formula Il-a, Il-b, II-c, and II- d wherein each of R⁶, R⁶ , R⁷ and R⁷ is deuterium. It will be appreciated that each row in Table 1 , Table 2, Table 3, and Table 4 represents four discrete compounds. For example, row 1 in Table 1 represents compounds II-a-1, Π-b-l, II-c-1 and II-d-1:

II-a-1 II-b-1 II-c-1 II-d-1

Table 1. Compounds of Formulae Il-a, Il-b, II-c, and Il-d wherein each of R⁶, R⁶ , R⁷ and

R⁷ is hydrogen.

/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

H D D H H H H H H H

H D H D H H H H H H

H D D D H H H H H H

D D D H H H H H H H

D D H D H H H H H H

D D D D H H H H H H

D H H H D H H H H H

D H H H H D H H H H

D H H H H H D H H H

D H H H H H H D H H

D H H H D D H H H H

D H H H D H D H H H

D H H H D H H D H H

D H H H H D D H H H

D H H H H D H D H H

D H H H H H D D H H

D H H H D D D H H H

D H H H D D H D H H

D H H H D H D D H H

D H H H H D D D H H

D H H H D D D D H H

H D H H D H H H H H

H D H H H D H H H H

H D H H H H D H H H

H D H H H H H D H H

H D H H D D H H H H

H D H H D H D H H H

H D H H D H H D H H

H D H H H D D H H H

H D H H H D H D H H

H D H H H H D D H H

H D H H D D D H H H

H D H H D D H D H H

H D H H D H D D H H

H D H H H D D D H H

H D H H D D D D H H

D D H H D H H H H H

D D H H H D H H H H

D D H H H H D H H H

D D H H H H H D H H

D D H H D D H H H H

D D H H D H D H H H

D D H H D H H D H H

D D H H H D D H H H

No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

292 D D H D D H H H H H

293 D D H D H D H H H H

294 D D H D H H D H H H

295 D D H D H H H D H H

296 D D H D D D H H H H

297 D D H D D H D H H H

298 D D H D D H H D H H

299 D D H D H D D H H H

300 D D H D H D H D H H

301 D D H D H H D D H H

302 D D H D D D D H H H

303 D D H D D D H D H H

304 D D H D D H D D H H

305 D D H D H D D D H H

306 D D H D D D D D H H

307 D D D D D H H H H H

308 D D D D H D H H H H

309 D D D D H H D H H H

310 D D D D H H H D H H

31 1 D D D D D D H H H H

312 D D D D D H D H H H

313 D D D D D H H D H H

314 D D D D H D D H H H

315 D D D D H D H D H H

316 D D D D H H D D H H

317 D D D D D D D H H H

318 D D D D D D H D H H

319 D D D D D H D D H H

320 D D D D H D D D H H

321 D D D D D D D D H H

322 D H D H H H H H D H

323 D H H D H H H H D H

324 D H D D H H H H D H

325 H D D H H H H H D H

326 H D H D H H H H D H

327 H D D D H H H H D H

328 D D D H H H H H D H

329 D D H D H H H H D H

330 D D D D H H H H D H

331 D H D H H H H H H D

332 D H H D H H H H H D

333 D H D D H H H H H D

334 H D D H H H H H H D

335 H D H D H H H H H D No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

336 H D D D H H H H H D

337 D D D H H H H H H D

338 D D H D H H H H H D

339 D D D D H H H H H D

340 D H D H H H H H D D

341 D H H D H H H H D D

342 D H D D H H H H D D

343 H D D H H H H H D D

344 H D H D H H H H D D

345 H D D D H H H H D D

346 D D D H H H H H D D

347 D D H D H H H H D D

348 D D D D H H H H D D

349 D H H H D H H H D H

350 D H H H H D H H D H

351 D H H H H H D H D H

352 D H H H H H H D D H

353 D H H H D D H H D H

354 D H H H D H D H D H

355 D H H H D H H D D H

356 D H H H H D D H D H

357 D H H H H D H D D H

358 D H H H H H D D D H

359 D H H H D D D H D H

360 D H H H D D H D D H

361 D H H H D H D D D H

362 D H H H H D D D D H

363 D H H H D D D D D H

364 D H H H D H H H H D

365 D H H H H D H H H D

366 D H H H H H D H H D

367 D H H H H H H D H D

368 D H H H D D H H H D

369 D H H H D H D H H D

370 D H H H D H H D H D

371 D H H H H D D H H D

372 D H H H H D H D H D

373 D H H H H H D D H D

374 D H H H D D D H H D

375 D H H H D D H D H D

376 D H H H D H D D H D

377 D H H H H D D D H D

378 D H H H D D D D H D

379 D H H H D H H H D D

600 H H D D D D H D H D

601 H H D D D H D D H D

602 H H D D H D D D H D

603 H H D D D D D D H D

604 H H D D D H H H D D

605 H H D D H D H H D D

606 H H D D H H D H D D

607 H H D D H H H D D D

608 H H D D D D H H D D

609 H H D D D H D H D D

610 H H D D D H H D D D

61 1 H H D D H D D H D D

612 H H D D H D H D D D

613 H H D D H H D D D D

614 H H D D D D D H D D

615 H H D D D D H D D D

616 H H D D D H D D D D

617 H H D D H D D D D D

618 H H D D D D D D D D

619 D H D H D H H H D H

620 D H D H H D H H D H

621 D H D H H H D H D H

622 D H D H H H H D D H

623 D H D H D D H H D H

624 D H D H D H D H D H

625 D H D H D H H D D H

626 D H D H H D D H D H

627 D H D H H D H D D H

628 D H D H H H D D D H

629 D H D H D D D H D H

630 D H D H D D H D D H

631 D H D H D H D D D H

632 D H D H H D D D D H

633 D H D H D D D D D H

634 D H H D D H H H D H

635 D H H D H D H H D H

636 D H H D H H D H D H

637 D H H D H H H D D H

638 D H H D D D H H D H

639 D H H D D H D H D H

640 D H H D D H H D D H

641 D H H D H D D H D H

642 D H H D H D H D D H

643 D H H D H H D D D H No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

644 D H H D D D D H D H

645 D H H D D D H D D H

646 D H H D D H D D D H

647 D H H D H D D D D H

648 D H H D D D D D D H

649 D H D D D H H H D H

650 D H D D H D H H D H

651 D H D D H H D H D H

652 D H D D H H H D D H

653 D H D D D D H H D H

654 D H D D D H D H D H

655 D H D D D H H D D H

656 D H D D H D D H D H

657 D H D D H D H D D H

658 D H D D H H D D D H

659 D H D D D D D H D H

660 D H D D D D H D D H

661 D H D D D H D D D H

662 D H D D H D D D D H

663 D H D D D D D D D H

664 H D D H D H H H D H

665 H D D H H D H H D H

666 H D D H H H D H D H

667 H D D H H H H D D H

668 H D D H D D H H D H

669 H D D H D H D H D H

670 H D D H D H H D D H

671 H D D H H D D H D H

672 H D D H H D H D D H

673 H D D H H H D D D H

674 H D D H D D D H D H

675 H D D H D D H D D H

676 H D D H D H D D D H

677 H D D H H D D D D H

678 H D D H D D D D D H

679 H D H D D H H H D H

680 H D H D H D H H D H

681 H D H D H H D H D H

682 H D H D H H H D D H

683 H D H D D D H H D H

684 H D H D D H D H D H

685 H D H D D H H D D H

686 H D H D H D D H D H

687 H D H D H D H D D H No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

688 H D H D H H D D D H

689 H D H D D D D H D H

690 H D H D D D H D D H

691 H D H D D H D D D H

692 H D H D H D D D D H

693 H D H D D D D D D H

694 H D D D D H H H D H

695 H D D D H D H H D H

696 H D D D H H D H D H

697 H D D D H H H D D H

698 H D D D D D H H D H

699 H D D D D H D H D H

700 H D D D D H H D D H

701 H D D D H D D H D H

702 H D D D H D H D D H

703 H D D D H H D D D H

704 H D D D D D D H D H

705 H D D D D D H D D H

706 H D D D D H D D D H

707 H D D D H D D D D H

708 H D D D D D D D D H

709 D D D H D H H H D H

710 D D D H H D H H D H

71 1 D D D H H H D H D H

712 D D D H H H H D D H

713 D D D H D D H H D H

714 D D D H D H D H D H

715 D D D H D H H D D H

716 D D D H H D D H D H

717 D D D H H D H D D H

718 D D D H H H D D D H

719 D D D H D D D H D H

720 D D D H D D H D D H

721 D D D H D H D D D H

722 D D D H H D D D D H

723 D D D H D D D D D H

724 D D H D D H H H D H

725 D D H D H D H H D H

726 D D H D H H D H D H

727 D D H D H H H D D H

728 D D H D D D H H D H

729 D D H D D H D H D H

730 D D H D D H H D D H

731 D D H D H D D H D H No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

732 D D H D H D H D D H

733 D D H D H H D D D H

734 D D H D D D D H D H

735 D D H D D D H D D H

736 D D H D D H D D D H

737 D D H D H D D D D H

738 D D H D D D D D D H

739 D D D D D H H H D H

740 D D D D H D H H D H

741 D D D D H H D H D H

742 D D D D H H H D D H

743 D D D D D D H H D H

744 D D D D D H D H D H

745 D D D D D H H D D H

746 D D D D H D D H D H

747 D D D D H D H D D H

748 D D D D H H D D D H

749 D D D D D D D H D H

750 D D D D D D H D D H

751 D D D D D H D D D H

752 D D D D H D D D D H

753 D D D D D D D D D H

754 D H D H D H H H H D

755 D H D H H D H H H D

756 D H D H H H D H H D

757 D H D H H H H D H D

758 D H D H D D H H H D

759 D H D H D H D H H D

760 D H D H D H H D H D

761 D H D H H D D H H D

762 D H D H H D H D H D

763 D H D H H H D D H D

764 D H D H D D D H H D

765 D H D H D D H D H D

766 D H D H D H D D H D

767 D H D H H D D D H D

768 D H D H D D D D H D

769 D H H D D H H H H D

770 D H H D H D H H H D

771 D H H D H H D H H D

772 D H H D H H H D H D

773 D H H D D D H H H D

774 D H H D D H D H H D

775 D H H D D H H D H D

908 D H H D D D H H D D

909 D H H D D H D H D D

910 D H H D D H H D D D

91 1 D H H D H D D H D D

912 D H H D H D H D D D

913 D H H D H H D D D D

914 D H H D D D D H D D

915 D H H D D D H D D D

916 D H H D D H D D D D

917 D H H D H D D D D D

918 D H H D D D D D D D

919 D H D D D H H H D D

920 D H D D H D H H D D

921 D H D D H H D H D D

922 D H D D H H H D D D

923 D H D D D D H H D D

924 D H D D D H D H D D

925 D H D D D H H D D D

926 D H D D H D D H D D

927 D H D D H D H D D D

928 D H D D H H D D D D

929 D H D D D D D H D D

930 D H D D D D H D D D

931 D H D D D H D D D D

932 D H D D H D D D D D

933 D H D D D D D D D D

934 H D D H D H H H D D

935 H D D H H D H H D D

936 H D D H H H D H D D

937 H D D H H H H D D D

938 H D D H D D H H D D

939 H D D H D H D H D D

940 H D D H D H H D D D

941 H D D H H D D H D D

942 H D D H H D H D D D

943 H D D H H H D D D D

944 H D D H D D D H D D

945 H D D H D D H D D D

946 H D D H D H D D D D

947 H D D H H D D D D D

948 H D D H D D D D D D

949 H D H D D H H H D D

950 H D H D H D H H D D

951 H D H D H H D H D D No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

952 H D H D H H H D D D

953 H D H D D D H H D D

954 H D H D D H D H D D

955 H D H D D H H D D D

956 H D H D H D D H D D

957 H D H D H D H D D D

958 H D H D H H D D D D

959 H D H D D D D H D D

960 H D H D D D H D D D

961 H D H D D H D D D D

962 H D H D H D D D D D

963 H D H D D D D D D D

964 H D D D D H H H D D

965 H D D D H D H H D D

966 H D D D H H D H D D

967 H D D D H H H D D D

968 H D D D D D H H D D

969 H D D D D H D H D D

970 H D D D D H H D D D

971 H D D D H D D H D D

972 H D D D H D H D D D

973 H D D D H H D D D D

974 H D D D D D D H D D

975 H D D D D D H D D D

976 H D D D D H D D D D

977 H D D D H D D D D D

978 H D D D D D D D D D

979 D D D H D H H H D D

980 D D D H H D H H D D

981 D D D H H H D H D D

982 D D D H H H H D D D

983 D D D H D D H H D D

984 D D D H D H D H D D

985 D D D H D H H D D D

986 D D D H H D D H D D

987 D D D H H D H D D D

988 D D D H H H D D D D

989 D D D H D D D H D D

990 D D D H D D H D D D

991 D D D H D H D D D D

992 D D D H H D D D D D

993 D D D H D D D D D D

994 D D H D D H H H D D

995 D D H D H D H H D D

Table 2. Compounds of Formulae Il-a, Il-b, Π-c, and Il-d wherein each of R⁶ and R⁶ is hydrogen and each of R 7 and R 7' is deuterium.

No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"''

1430 H D H H D H D D D H

1431 H D H H H D D D D H

1432 H D H H D D D D D H

1433 H D H H D H H H H D

1434 H D H H H D H H H D

1435 H D H H H H D H H D

1436 H D H H H H H D H D

1437 H D H H D D H H H D

1438 H D H H D H D H H D

1439 H D H H D H H D H D

1440 H D H H H D D H H D

1441 H D H H H D H D H D

1442 H D H H H H D D H D

1443 H D H H D D D H H D

1444 H D H H D D H D H D

1445 H D H H D H D D H D

1446 H D H H H D D D H D

1447 H D H H D D D D H D

1448 H D H H D H H H D D

1449 H D H H H D H H D D

1450 H D H H H H D H D D

1451 H D H H H H H D D D

1452 H D H H D D H H D D

1453 H D H H D H D H D D

1454 H D H H D H H D D D

1455 H D H H H D D H D D

1456 H D H H H D H D D D

1457 H D H H H H D D D D

1458 H D H H D D D H D D

1459 H D H H D D H D D D

1460 H D H H D H D D D D

1461 H D H H H D D D D D

1462 H D H H D D D D D D

1463 D D H H D H H H D H

1464 D D H H H D H H D H

1465 D D H H H H D H D H

1466 D D H H H H H D D H

1467 D D H H D D H H D H

1468 D D H H D H D H D H

1469 D D H H D H H D D H

1470 D D H H H D D H D H

1471 D D H H H D H D D H

1472 D D H H H H D D D H

1473 D D H H D D D H D H

1870 D D D H H H D H H D

1871 D D D H H H H D H D

1872 D D D H D D H H H D

1873 D D D H D H D H H D

1874 D D D H D H H D H D

1875 D D D H H D D H H D

1876 D D D H H D H D H D

1877 D D D H H H D D H D

1878 D D D H D D D H H D

1879 D D D H D D H D H D

1880 D D D H D H D D H D

1881 D D D H H D D D H D

1882 D D D H D D D D H D

1883 D D H D D H H H H D

1884 D D H D H D H H H D

1885 D D H D H H D H H D

1886 D D H D H H H D H D

1887 D D H D D D H H H D

1888 D D H D D H D H H D

1889 D D H D D H H D H D

1890 D D H D H D D H H D

1891 D D H D H D H D H D

1892 D D H D H H D D H D

1893 D D H D D D D H H D

1894 D D H D D D H D H D

1895 D D H D D H D D H D

1896 D D H D H D D D H D

1897 D D H D D D D D H D

1898 D D D D D H H H H D

1899 D D D D H D H H H D

1900 D D D D H H D H H D

1901 D D D D H H H D H D

1902 D D D D D D H H H D

1903 D D D D D H D H H D

1904 D D D D D H H D H D

1905 D D D D H D D H H D

1906 D D D D H D H D H D

1907 D D D D H H D D H D

1908 D D D D D D D H H D

1909 D D D D D D H D H D

1910 D D D D D H D D H D

1911 D D D D H D D D H D

1912 D D D D D D D D H D

1913 D H D H D H H H D D

1958 H D D H D H H H D D

1959 H D D H H D H H D D

1960 H D D H H H D H D D

1961 H D D H H H H D D D

1962 H D D H D D H H D D

1963 H D D H D H D H D D

1964 H D D H D H H D D D

1965 H D D H H D D H D D

1966 H D D H H D H D D D

1967 H D D H H H D D D D

1968 H D D H D D D H D D

1969 H D D H D D H D D D

1970 H D D H D H D D D D

1971 H D D H H D D D D D

1972 H D D H D D D D D D

1973 H D H D D H H H D D

1974 H D H D H D H H D D

1975 H D H D H H D H D D

1976 H D H D H H H D D D

1977 H D H D D D H H D D

1978 H D H D D H D H D D

1979 H D H D D H H D D D

1980 H D H D H D D H D D

1981 H D H D H D H D D D

1982 H D H D H H D D D D

1983 H D H D D D D H D D

1984 H D H D D D H D D D

1985 H D H D D H D D D D

1986 H D H D H D D D D D

1987 H D H D D D D D D D

1988 H D D D D H H H D D

1989 H D D D H D H H D D

1990 H D D D H H D H D D

1991 H D D D H H H D D D

1992 H D D D D D H H D D

1993 H D D D D H D H D D

1994 H D D D D H H D D D

1995 H D D D H D D H D D

1996 H D D D H D H D D D

1997 H D D D H H D D D D

1998 H D D D D D D H D D

1999 H D D D D D H D D D

2000 H D D D D H D D D D

2001 H D D D H D D D D D

No. R^8a/R^8a R^8b/R^8b' R^9a/R^9a' R^9b/R^9b' _Rxa _Rxb _Rxb' _Rxc R^ya/R^ya R^yl7R^yb'

2046 D D D D H D D D D D

2047 D D D D D D D D D D

Table 3. Compounds of Formulae Il-a i, Il-b, Π- c, and Il-d wherein each of R⁶ and R⁶ is deuterium and each of R 7 and R 7' is hydrogen.

No. R^8a/R^8a R^8b/R^8b' R^9a/R^9a' R^9b/R^9b' _Rxa _Rxb _Rxb _Rxc R^ya/R^ya R^yb/R^yb'

2048 H H H H H H H H H H

2049 D H H H H H H H H H

2050 H D H H H H H H H H

2051 D D H H H H H H H H

2052 H H D H H H H H H H

2053 H H H D H H H H H H

2054 H H D D H H H H H H

2055 H H H H D H H H H H

2056 H H H H H D H H H H

2057 H H H H H H D H H H

2058 H H H H H H H D H H

2059 H H H H D D H H H H

2060 H H H H D H D H H H

2061 H H H H D H H D H H

2062 H H H H H D D H H H

2063 H H H H H D H D H H

2064 H H H H H H D D H H

2065 H H H H D D D H H H

2066 H H H H D D H D H H

2067 H H H H D H D D H H

2068 H H H H H D D D H H

2069 H H H H D D D D H H

2070 H H H H H H H H D H

2071 H H H H H H H H H D

2072 H H H H H H H H D D

2073 D H D H H H H H H H

2074 D H H D H H H H H H

2075 D H D D H H H H H H

2076 H D D H H H H H H H

2077 H D H D H H H H H H

2078 H D D D H H H H H H

2079 D D D H H H H H H H

2080 D D H D H H H H H H

2081 D D D D H H H H H H

2082 D H H H D H H H H H

2083 D H H H H D H H H H No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2084 D H H H H H D H H H

2085 D H H H H H H D H H

2086 D H H H D D H H H H

2087 D H H H D H D H H H

2088 D H H H D H H D H H

2089 D H H H H D D H H H

2090 D H H H H D H D H H

2091 D H H H H H D D H H

2092 D H H H D D D H H H

2093 D H H H D D H D H H

2094 D H H H D H D D H H

2095 D H H H H D D D H H

2096 D H H H D D D D H H

2097 H D H H D H H H H H

2098 H D H H H D H H H H

2099 H D H H H H D H H H

2100 H D H H H H H D H H

2101 H D H H D D H H H H

2102 H D H H D H D H H H

2103 H D H H D H H D H H

2104 H D H H H D D H H H

2105 H D H H H D H D H H

2106 H D H H H H D D H H

2107 H D H H D D D H H H

2108 H D H H D D H D H H

2109 H D H H D H D D H H

2110 H D H H H D D D H H

2111 H D H H D D D D H H

2112 D D H H D H H H H H

2113 D D H H H D H H H H

2114 D D H H H H D H H H

2115 D D H H H H H D H H

2116 D D H H D D H H H H

2117 D D H H D H D H H H

2118 D D H H D H H D H H

2119 D D H H H D D H H H

2120 D D H H H D H D H H

2121 D D H H H H D D H H

2122 D D H H D D D H H H

2123 D D H H D D H D H H

2124 D D H H D H D D H H

2125 D D H H H D D D H H

2126 D D H H D D D D H H

2127 D H H H H H H H D H No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2128 D H H H H H H H H D

2129 D H H H H H H H D D

2130 H D H H H H H H D H

2131 H D H H H H H H H D

2132 H D H H H H H H D D

2133 D D H H H H H H D H

2134 D D H H H H H H H D

2135 D D H H H H H H D D

2136 H H D H D H H H H H

2137 H H D H H D H H H H

2138 H H D H H H D H H H

2139 H H D H H H H D H H

2140 H H D H D D H H H H

2141 H H D H D H D H H H

2142 H H D H D H H D H H

2143 H H D H H D D H H H

2144 H H D H H D H D H H

2145 H H D H H H D D H H

2146 H H D H D D D H H H

2147 H H D H D D H D H H

2148 H H D H D H D D H H

2149 H H D H H D D D H H

2150 H H D H D D D D H H

2151 H H H D D H H H H H

2152 H H H D H D H H H H

2153 H H H D H H D H H H

2154 H H H D H H H D H H

2155 H H H D D D H H H H

2156 H H H D D H D H H H

2157 H H H D D H H D H H

2158 H H H D H D D H H H

2159 H H H D H D H D H H

2160 H H H D H H D D H H

2161 H H H D D D D H H H

2162 H H H D D D H D H H

2163 H H H D D H D D H H

2164 H H H D H D D D H H

2165 H H H D D D D D H H

2166 H H D D D H H H H H

2167 H H D D H D H H H H

2168 H H D D H H D H H H

2169 H H D D H H H D H H

2170 H H D D D D H H H H

2171 H H D D D H D H H H No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2172 H H D D D H H D H H

2173 H H D D H D D H H H

2174 H H D D H D H D H H

2175 H H D D H H D D H H

2176 H H D D D D D H H H

2177 H H D D D D H D H H

2178 H H D D D H D D H H

2179 H H D D H D D D H H

2180 H H D D D D D D H H

2181 H H D H H H H H D H

2182 H H D H H H H H H D

2183 H H D H H H H H D D

2184 H H H D H H H H D H

2185 H H H D H H H H H D

2186 H H H D H H H H D D

2187 H H D D H H H H D H

2188 H H D D H H H H H D

2189 H H D D H H H H D D

2190 H H H H D H H H D H

2191 H H H H H D H H D H

2192 H H H H H H D H D H

2193 H H H H H H H D D H

2194 H H H H D D H H D H

2195 H H H H D H D H D H

2196 H H H H D H H D D H

2197 H H H H H D D H D H

2198 H H H H H D H D D H

2199 H H H H H H D D D H

2200 H H H H D D D H D H

2201 H H H H D D H D D H

2202 H H H H D H D D D H

2203 H H H H H D D D D H

2204 H H H H D D D D D H

2205 H H H H D H H H H D

2206 H H H H H D H H H D

2207 H H H H H H D H H D

2208 H H H H H H H D H D

2209 H H H H D D H H H D

2210 H H H H D H D H H D

2211 H H H H D H H D H D

2212 H H H H H D D H H D

2213 H H H H H D H D H D

2214 H H H H H H D D H D

2215 H H H H D D D H H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2216 H H H H D D H D H D

2217 H H H H D H D D H D

2218 H H H H H D D D H D

2219 H H H H D D D D H D

2220 H H H H D H H H D D

2221 H H H H H D H H D D

2222 H H H H H H D H D D

2223 H H H H H H H D D D

2224 H H H H D D H H D D

2225 H H H H D H D H D D

2226 H H H H D H H D D D

2227 H H H H H D D H D D

2228 H H H H H D H D D D

2229 H H H H H H D D D D

2230 H H H H D D D H D D

2231 H H H H D D H D D D

2232 H H H H D H D D D D

2233 H H H H H D D D D D

2234 H H H H D D D D D D

2235 D H D H D H H H H H

2236 D H D H H D H H H H

2237 D H D H H H D H H H

2238 D H D H H H H D H H

2239 D H D H D D H H H H

2240 D H D H D H D H H H

2241 D H D H D H H D H H

2242 D H D H H D D H H H

2243 D H D H H D H D H H

2244 D H D H H H D D H H

2245 D H D H D D D H H H

2246 D H D H D D H D H H

2247 D H D H D H D D H H

2248 D H D H H D D D H H

2249 D H D H D D D D H H

2250 D H H D D H H H H H

2251 D H H D H D H H H H

2252 D H H D H H D H H H

2253 D H H D H H H D H H

2254 D H H D D D H H H H

2255 D H H D D H D H H H

2256 D H H D D H H D H H

2257 D H H D H D D H H H

2258 D H H D H D H D H H

2259 D H H D H H D D H H No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2260 D H H D D D D H H H

2261 D H H D D D H D H H

2262 D H H D D H D D H H

2263 D H H D H D D D H H

2264 D H H D D D D D H H

2265 D H D D D H H H H H

2266 D H D D H D H H H H

2267 D H D D H H D H H H

2268 D H D D H H H D H H

2269 D H D D D D H H H H

2270 D H D D D H D H H H

2271 D H D D D H H D H H

2272 D H D D H D D H H H

2273 D H D D H D H D H H

2274 D H D D H H D D H H

2275 D H D D D D D H H H

2276 D H D D D D H D H H

2277 D H D D D H D D H H

2278 D H D D H D D D H H

2279 D H D D D D D D H H

2280 H D D H D H H H H H

2281 H D D H H D H H H H

2282 H D D H H H D H H H

2283 H D D H H H H D H H

2284 H D D H D D H H H H

2285 H D D H D H D H H H

2286 H D D H D H H D H H

2287 H D D H H D D H H H

2288 H D D H H D H D H H

2289 H D D H H H D D H H

2290 H D D H D D D H H H

2291 H D D H D D H D H H

2292 H D D H D H D D H H

2293 H D D H H D D D H H

2294 H D D H D D D D H H

2295 H D H D D H H H H H

2296 H D H D H D H H H H

2297 H D H D H H D H H H

2298 H D H D H H H D H H

2299 H D H D D D H H H H

2300 H D H D D H D H H H

2301 H D H D D H H D H H

2302 H D H D H D D H H H

2303 H D H D H D H D H H No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2304 H D H D H H D D H H

2305 H D H D D D D H H H

2306 H D H D D D H D H H

2307 H D H D D H D D H H

2308 H D H D H D D D H H

2309 H D H D D D D D H H

2310 H D D D D H H H H H

2311 H D D D H D H H H H

2312 H D D D H H D H H H

2313 H D D D H H H D H H

2314 H D D D D D H H H H

2315 H D D D D H D H H H

2316 H D D D D H H D H H

2317 H D D D H D D H H H

2318 H D D D H D H D H H

2319 H D D D H H D D H H

2320 H D D D D D D H H H

2321 H D D D D D H D H H

2322 H D D D D H D D H H

2323 H D D D H D D D H H

2324 H D D D D D D D H H

2325 D D D H D H H H H H

2326 D D D H H D H H H H

2327 D D D H H H D H H H

2328 D D D H H H H D H H

2329 D D D H D D H H H H

2330 D D D H D H D H H H

2331 D D D H D H H D H H

2332 D D D H H D D H H H

2333 D D D H H D H D H H

2334 D D D H H H D D H H

2335 D D D H D D D H H H

2336 D D D H D D H D H H

2337 D D D H D H D D H H

2338 D D D H H D D D H H

2339 D D D H D D D D H H

2340 D D H D D H H H H H

2341 D D H D H D H H H H

2342 D D H D H H D H H H

2343 D D H D H H H D H H

2344 D D H D D D H H H H

2345 D D H D D H D H H H

2346 D D H D D H H D H H

2347 D D H D H D D H H H No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2348 D D H D H D H D H H

2349 D D H D H H D D H H

2350 D D H D D D D H H H

2351 D D H D D D H D H H

2352 D D H D D H D D H H

2353 D D H D H D D D H H

2354 D D H D D D D D H H

2355 D D D D D H H H H H

2356 D D D D H D H H H H

2357 D D D D H H D H H H

2358 D D D D H H H D H H

2359 D D D D D D H H H H

2360 D D D D D H D H H H

2361 D D D D D H H D H H

2362 D D D D H D D H H H

2363 D D D D H D H D H H

2364 D D D D H H D D H H

2365 D D D D D D D H H H

2366 D D D D D D H D H H

2367 D D D D D H D D H H

2368 D D D D H D D D H H

2369 D D D D D D D D H H

2370 D H D H H H H H D H

2371 D H H D H H H H D H

2372 D H D D H H H H D H

2373 H D D H H H H H D H

2374 H D H D H H H H D H

2375 H D D D H H H H D H

2376 D D D H H H H H D H

2377 D D H D H H H H D H

2378 D D D D H H H H D H

2379 D H D H H H H H H D

2380 D H H D H H H H H D

2381 D H D D H H H H H D

2382 H D D H H H H H H D

2383 H D H D H H H H H D

2384 H D D D H H H H H D

2385 D D D H H H H H H D

2386 D D H D H H H H H D

2387 D D D D H H H H H D

2388 D H D H H H H H D D

2389 D H H D H H H H D D

2390 D H D D H H H H D D

2391 H D D H H H H H D D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2392 H D H D H H H H D D

2393 H D D D H H H H D D

2394 D D D H H H H H D D

2395 D D H D H H H H D D

2396 D D D D H H H H D D

2397 D H H H D H H H D H

2398 D H H H H D H H D H

2399 D H H H H H D H D H

2400 D H H H H H H D D H

2401 D H H H D D H H D H

2402 D H H H D H D H D H

2403 D H H H D H H D D H

2404 D H H H H D D H D H

2405 D H H H H D H D D H

2406 D H H H H H D D D H

2407 D H H H D D D H D H

2408 D H H H D D H D D H

2409 D H H H D H D D D H

2410 D H H H H D D D D H

2411 D H H H D D D D D H

2412 D H H H D H H H H D

2413 D H H H H D H H H D

2414 D H H H H H D H H D

2415 D H H H H H H D H D

2416 D H H H D D H H H D

2417 D H H H D H D H H D

2418 D H H H D H H D H D

2419 D H H H H D D H H D

2420 D H H H H D H D H D

2421 D H H H H H D D H D

2422 D H H H D D D H H D

2423 D H H H D D H D H D

2424 D H H H D H D D H D

2425 D H H H H D D D H D

2426 D H H H D D D D H D

2427 D H H H D H H H D D

2428 D H H H H D H H D D

2429 D H H H H H D H D D

2430 D H H H H H H D D D

2431 D H H H D D H H D D

2432 D H H H D H D H D D

2433 D H H H D H H D D D

2434 D H H H H D D H D D

2435 D H H H H D H D D D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2436 D H H H H H D D D D

2437 D H H H D D D H D D

2438 D H H H D D H D D D

2439 D H H H D H D D D D

2440 D H H H H D D D D D

2441 D H H H D D D D D D

2442 H D H H D H H H D H

2443 H D H H H D H H D H

2444 H D H H H H D H D H

2445 H D H H H H H D D H

2446 H D H H D D H H D H

2447 H D H H D H D H D H

2448 H D H H D H H D D H

2449 H D H H H D D H D H

2450 H D H H H D H D D H

2451 H D H H H H D D D H

2452 H D H H D D D H D H

2453 H D H H D D H D D H

2454 H D H H D H D D D H

2455 H D H H H D D D D H

2456 H D H H D D D D D H

2457 H D H H D H H H H D

2458 H D H H H D H H H D

2459 H D H H H H D H H D

2460 H D H H H H H D H D

2461 H D H H D D H H H D

2462 H D H H D H D H H D

2463 H D H H D H H D H D

2464 H D H H H D D H H D

2465 H D H H H D H D H D

2466 H D H H H H D D H D

2467 H D H H D D D H H D

2468 H D H H D D H D H D

2469 H D H H D H D D H D

2470 H D H H H D D D H D

2471 H D H H D D D D H D

2472 H D H H D H H H D D

2473 H D H H H D H H D D

2474 H D H H H H D H D D

2475 H D H H H H H D D D

2476 H D H H D D H H D D

2477 H D H H D H D H D D

2478 H D H H D H H D D D

2479 H D H H H D D H D D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2480 H D H H H D H D D D

2481 H D H H H H D D D D

2482 H D H H D D D H D D

2483 H D H H D D H D D D

2484 H D H H D H D D D D

2485 H D H H H D D D D D

2486 H D H H D D D D D D

2487 D D H H D H H H D H

2488 D D H H H D H H D H

2489 D D H H H H D H D H

2490 D D H H H H H D D H

2491 D D H H D D H H D H

2492 D D H H D H D H D H

2493 D D H H D H H D D H

2494 D D H H H D D H D H

2495 D D H H H D H D D H

2496 D D H H H H D D D H

2497 D D H H D D D H D H

2498 D D H H D D H D D H

2499 D D H H D H D D D H

2500 D D H H H D D D D H

2501 D D H H D D D D D H

2502 D D H H D H H H H D

2503 D D H H H D H H H D

2504 D D H H H H D H H D

2505 D D H H H H H D H D

2506 D D H H D D H H H D

2507 D D H H D H D H H D

2508 D D H H D H H D H D

2509 D D H H H D D H H D

2510 D D H H H D H D H D

2511 D D H H H H D D H D

2512 D D H H D D D H H D

2513 D D H H D D H D H D

2514 D D H H D H D D H D

2515 D D H H H D D D H D

2516 D D H H D D D D H D

2517 D D H H D H H H D D

2518 D D H H H D H H D D

2519 D D H H H H D H D D

2520 D D H H H H H D D D

2521 D D H H D D H H D D

2522 D D H H D H D H D D

2523 D D H H D H H D D D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2524 D D H H H D D H D D

2525 D D H H H D H D D D

2526 D D H H H H D D D D

2527 D D H H D D D H D D

2528 D D H H D D H D D D

2529 D D H H D H D D D D

2530 D D H H H D D D D D

2531 D D H H D D D D D D

2532 H H D H D H H H D H

2533 H H D H H D H H D H

2534 H H D H H H D H D H

2535 H H D H H H H D D H

2536 H H D H D D H H D H

2537 H H D H D H D H D H

2538 H H D H D H H D D H

2539 H H D H H D D H D H

2540 H H D H H D H D D H

2541 H H D H H H D D D H

2542 H H D H D D D H D H

2543 H H D H D D H D D H

2544 H H D H D H D D D H

2545 H H D H H D D D D H

2546 H H D H D D D D D H

2547 H H D H D H H H H D

2548 H H D H H D H H H D

2549 H H D H H H D H H D

2550 H H D H H H H D H D

2551 H H D H D D H H H D

2552 H H D H D H D H H D

2553 H H D H D H H D H D

2554 H H D H H D D H H D

2555 H H D H H D H D H D

2556 H H D H H H D D H D

2557 H H D H D D D H H D

2558 H H D H D D H D H D

2559 H H D H D H D D H D

2560 H H D H H D D D H D

2561 H H D H D D D D H D

2562 H H D H D H H H D D

2563 H H D H H D H H D D

2564 H H D H H H D H D D

2565 H H D H H H H D D D

2566 H H D H D D H H D D

2567 H H D H D H D H D D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2568 H H D H D H H D D D

2569 H H D H H D D H D D

2570 H H D H H D H D D D

2571 H H D H H H D D D D

2572 H H D H D D D H D D

2573 H H D H D D H D D D

2574 H H D H D H D D D D

2575 H H D H H D D D D D

2576 H H D H D D D D D D

2577 H H H D D H H H D H

2578 H H H D H D H H D H

2579 H H H D H H D H D H

2580 H H H D H H H D D H

2581 H H H D D D H H D H

2582 H H H D D H D H D H

2583 H H H D D H H D D H

2584 H H H D H D D H D H

2585 H H H D H D H D D H

2586 H H H D H H D D D H

2587 H H H D D D D H D H

2588 H H H D D D H D D H

2589 H H H D D H D D D H

2590 H H H D H D D D D H

2591 H H H D D D D D D H

2592 H H H D D H H H H D

2593 H H H D H D H H H D

2594 H H H D H H D H H D

2595 H H H D H H H D H D

2596 H H H D D D H H H D

2597 H H H D D H D H H D

2598 H H H D D H H D H D

2599 H H H D H D D H H D

2600 H H H D H D H D H D

2601 H H H D H H D D H D

2602 H H H D D D D H H D

2603 H H H D D D H D H D

2604 H H H D D H D D H D

2605 H H H D H D D D H D

2606 H H H D D D D D H D

2607 H H H D D H H H D D

2608 H H H D H D H H D D

2609 H H H D H H D H D D

2610 H H H D H H H D D D

2611 H H H D D D H H D D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2612 H H H D D H D H D D

2613 H H H D D H H D D D

2614 H H H D H D D H D D

2615 H H H D H D H D D D

2616 H H H D H H D D D D

2617 H H H D D D D H D D

2618 H H H D D D H D D D

2619 H H H D D H D D D D

2620 H H H D H D D D D D

2621 H H H D D D D D D D

2622 H H D D D H H H D H

2623 H H D D H D H H D H

2624 H H D D H H D H D H

2625 H H D D H H H D D H

2626 H H D D D D H H D H

2627 H H D D D H D H D H

2628 H H D D D H H D D H

2629 H H D D H D D H D H

2630 H H D D H D H D D H

2631 H H D D H H D D D H

2632 H H D D D D D H D H

2633 H H D D D D H D D H

2634 H H D D D H D D D H

2635 H H D D H D D D D H

2636 H H D D D D D D D H

2637 H H D D D H H H H D

2638 H H D D H D H H H D

2639 H H D D H H D H H D

2640 H H D D H H H D H D

2641 H H D D D D H H H D

2642 H H D D D H D H H D

2643 H H D D D H H D H D

2644 H H D D H D D H H D

2645 H H D D H D H D H D

2646 H H D D H H D D H D

2647 H H D D D D D H H D

2648 H H D D D D H D H D

2649 H H D D D H D D H D

2650 H H D D H D D D H D

2651 H H D D D D D D H D

2652 H H D D D H H H D D

2653 H H D D H D H H D D

2654 H H D D H H D H D D

2655 H H D D H H H D D D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2656 H H D D D D H H D D

2657 H H D D D H D H D D

2658 H H D D D H H D D D

2659 H H D D H D D H D D

2660 H H D D H D H D D D

2661 H H D D H H D D D D

2662 H H D D D D D H D D

2663 H H D D D D H D D D

2664 H H D D D H D D D D

2665 H H D D H D D D D D

2666 H H D D D D D D D D

2667 D H D H D H H H D H

2668 D H D H H D H H D H

2669 D H D H H H D H D H

2670 D H D H H H H D D H

2671 D H D H D D H H D H

2672 D H D H D H D H D H

2673 D H D H D H H D D H

2674 D H D H H D D H D H

2675 D H D H H D H D D H

2676 D H D H H H D D D H

2677 D H D H D D D H D H

2678 D H D H D D H D D H

2679 D H D H D H D D D H

2680 D H D H H D D D D H

2681 D H D H D D D D D H

2682 D H H D D H H H D H

2683 D H H D H D H H D H

2684 D H H D H H D H D H

2685 D H H D H H H D D H

2686 D H H D D D H H D H

2687 D H H D D H D H D H

2688 D H H D D H H D D H

2689 D H H D H D D H D H

2690 D H H D H D H D D H

2691 D H H D H H D D D H

2692 D H H D D D D H D H

2693 D H H D D D H D D H

2694 D H H D D H D D D H

2695 D H H D H D D D D H

2696 D H H D D D D D D H

2697 D H D D D H H H D H

2698 D H D D H D H H D H

2699 D H D D H H D H D H No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2700 D H D D H H H D D H

2701 D H D D D D H H D H

2702 D H D D D H D H D H

2703 D H D D D H H D D H

2704 D H D D H D D H D H

2705 D H D D H D H D D H

2706 D H D D H H D D D H

2707 D H D D D D D H D H

2708 D H D D D D H D D H

2709 D H D D D H D D D H

2710 D H D D H D D D D H

2711 D H D D D D D D D H

2712 H D D H D H H H D H

2713 H D D H H D H H D H

2714 H D D H H H D H D H

2715 H D D H H H H D D H

2716 H D D H D D H H D H

2717 H D D H D H D H D H

2718 H D D H D H H D D H

2719 H D D H H D D H D H

2720 H D D H H D H D D H

2721 H D D H H H D D D H

2722 H D D H D D D H D H

2723 H D D H D D H D D H

2724 H D D H D H D D D H

2725 H D D H H D D D D H

2726 H D D H D D D D D H

2727 H D H D D H H H D H

2728 H D H D H D H H D H

2729 H D H D H H D H D H

2730 H D H D H H H D D H

2731 H D H D D D H H D H

2732 H D H D D H D H D H

2733 H D H D D H H D D H

2734 H D H D H D D H D H

2735 H D H D H D H D D H

2736 H D H D H H D D D H

2737 H D H D D D D H D H

2738 H D H D D D H D D H

2739 H D H D D H D D D H

2740 H D H D H D D D D H

2741 H D H D D D D D D H

2742 H D D D D H H H D H

2743 H D D D H D H H D H No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2744 H D D D H H D H D H

2745 H D D D H H H D D H

2746 H D D D D D H H D H

2747 H D D D D H D H D H

2748 H D D D D H H D D H

2749 H D D D H D D H D H

2750 H D D D H D H D D H

2751 H D D D H H D D D H

2752 H D D D D D D H D H

2753 H D D D D D H D D H

2754 H D D D D H D D D H

2755 H D D D H D D D D H

2756 H D D D D D D D D H

2757 D D D H D H H H D H

2758 D D D H H D H H D H

2759 D D D H H H D H D H

2760 D D D H H H H D D H

2761 D D D H D D H H D H

2762 D D D H D H D H D H

2763 D D D H D H H D D H

2764 D D D H H D D H D H

2765 D D D H H D H D D H

2766 D D D H H H D D D H

2767 D D D H D D D H D H

2768 D D D H D D H D D H

2769 D D D H D H D D D H

2770 D D D H H D D D D H

2771 D D D H D D D D D H

2772 D D H D D H H H D H

2773 D D H D H D H H D H

2774 D D H D H H D H D H

2775 D D H D H H H D D H

2776 D D H D D D H H D H

2777 D D H D D H D H D H

2778 D D H D D H H D D H

2779 D D H D H D D H D H

2780 D D H D H D H D D H

2781 D D H D H H D D D H

2782 D D H D D D D H D H

2783 D D H D D D H D D H

2784 D D H D D H D D D H

2785 D D H D H D D D D H

2786 D D H D D D D D D H

2787 D D D D D H H H D H No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2788 D D D D H D H H D H

2789 D D D D H H D H D H

2790 D D D D H H H D D H

2791 D D D D D D H H D H

2792 D D D D D H D H D H

2793 D D D D D H H D D H

2794 D D D D H D D H D H

2795 D D D D H D H D D H

2796 D D D D H H D D D H

2797 D D D D D D D H D H

2798 D D D D D D H D D H

2799 D D D D D H D D D H

2800 D D D D H D D D D H

2801 D D D D D D D D D H

2802 D H D H D H H H H D

2803 D H D H H D H H H D

2804 D H D H H H D H H D

2805 D H D H H H H D H D

2806 D H D H D D H H H D

2807 D H D H D H D H H D

2808 D H D H D H H D H D

2809 D H D H H D D H H D

2810 D H D H H D H D H D

2811 D H D H H H D D H D

2812 D H D H D D D H H D

2813 D H D H D D H D H D

2814 D H D H D H D D H D

2815 D H D H H D D D H D

2816 D H D H D D D D H D

2817 D H H D D H H H H D

2818 D H H D H D H H H D

2819 D H H D H H D H H D

2820 D H H D H H H D H D

2821 D H H D D D H H H D

2822 D H H D D H D H H D

2823 D H H D D H H D H D

2824 D H H D H D D H H D

2825 D H H D H D H D H D

2826 D H H D H H D D H D

2827 D H H D D D D H H D

2828 D H H D D D H D H D

2829 D H H D D H D D H D

2830 D H H D H D D D H D

2831 D H H D D D D D H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2832 D H D D D H H H H D

2833 D H D D H D H H H D

2834 D H D D H H D H H D

2835 D H D D H H H D H D

2836 D H D D D D H H H D

2837 D H D D D H D H H D

2838 D H D D D H H D H D

2839 D H D D H D D H H D

2840 D H D D H D H D H D

2841 D H D D H H D D H D

2842 D H D D D D D H H D

2843 D H D D D D H D H D

2844 D H D D D H D D H D

2845 D H D D H D D D H D

2846 D H D D D D D D H D

2847 H D D H D H H H H D

2848 H D D H H D H H H D

2849 H D D H H H D H H D

2850 H D D H H H H D H D

2851 H D D H D D H H H D

2852 H D D H D H D H H D

2853 H D D H D H H D H D

2854 H D D H H D D H H D

2855 H D D H H D H D H D

2856 H D D H H H D D H D

2857 H D D H D D D H H D

2858 H D D H D D H D H D

2859 H D D H D H D D H D

2860 H D D H H D D D H D

2861 H D D H D D D D H D

2862 H D H D D H H H H D

2863 H D H D H D H H H D

2864 H D H D H H D H H D

2865 H D H D H H H D H D

2866 H D H D D D H H H D

2867 H D H D D H D H H D

2868 H D H D D H H D H D

2869 H D H D H D D H H D

2870 H D H D H D H D H D

2871 H D H D H H D D H D

2872 H D H D D D D H H D

2873 H D H D D D H D H D

2874 H D H D D H D D H D

2875 H D H D H D D D H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2876 H D H D D D D D H D

2877 H D D D D H H H H D

2878 H D D D H D H H H D

2879 H D D D H H D H H D

2880 H D D D H H H D H D

2881 H D D D D D H H H D

2882 H D D D D H D H H D

2883 H D D D D H H D H D

2884 H D D D H D D H H D

2885 H D D D H D H D H D

2886 H D D D H H D D H D

2887 H D D D D D D H H D

2888 H D D D D D H D H D

2889 H D D D D H D D H D

2890 H D D D H D D D H D

2891 H D D D D D D D H D

2892 D D D H D H H H H D

2893 D D D H H D H H H D

2894 D D D H H H D H H D

2895 D D D H H H H D H D

2896 D D D H D D H H H D

2897 D D D H D H D H H D

2898 D D D H D H H D H D

2899 D D D H H D D H H D

2900 D D D H H D H D H D

2901 D D D H H H D D H D

2902 D D D H D D D H H D

2903 D D D H D D H D H D

2904 D D D H D H D D H D

2905 D D D H H D D D H D

2906 D D D H D D D D H D

2907 D D H D D H H H H D

2908 D D H D H D H H H D

2909 D D H D H H D H H D

2910 D D H D H H H D H D

2911 D D H D D D H H H D

2912 D D H D D H D H H D

2913 D D H D D H H D H D

2914 D D H D H D D H H D

2915 D D H D H D H D H D

2916 D D H D H H D D H D

2917 D D H D D D D H H D

2918 D D H D D D H D H D

2919 D D H D D H D D H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2920 D D H D H D D D H D

2921 D D H D D D D D H D

2922 D D D D D H H H H D

2923 D D D D H D H H H D

2924 D D D D H H D H H D

2925 D D D D H H H D H D

2926 D D D D D D H H H D

2927 D D D D D H D H H D

2928 D D D D D H H D H D

2929 D D D D H D D H H D

2930 D D D D H D H D H D

2931 D D D D H H D D H D

2932 D D D D D D D H H D

2933 D D D D D D H D H D

2934 D D D D D H D D H D

2935 D D D D H D D D H D

2936 D D D D D D D D H D

2937 D H D H D H H H D D

2938 D H D H H D H H D D

2939 D H D H H H D H D D

2940 D H D H H H H D D D

2941 D H D H D D H H D D

2942 D H D H D H D H D D

2943 D H D H D H H D D D

2944 D H D H H D D H D D

2945 D H D H H D H D D D

2946 D H D H H H D D D D

2947 D H D H D D D H D D

2948 D H D H D D H D D D

2949 D H D H D H D D D D

2950 D H D H H D D D D D

2951 D H D H D D D D D D

2952 D H H D D H H H D D

2953 D H H D H D H H D D

2954 D H H D H H D H D D

2955 D H H D H H H D D D

2956 D H H D D D H H D D

2957 D H H D D H D H D D

2958 D H H D D H H D D D

2959 D H H D H D D H D D

2960 D H H D H D H D D D

2961 D H H D H H D D D D

2962 D H H D D D D H D D

2963 D H H D D D H D D D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2964 D H H D D H D D D D

2965 D H H D H D D D D D

2966 D H H D D D D D D D

2967 D H D D D H H H D D

2968 D H D D H D H H D D

2969 D H D D H H D H D D

2970 D H D D H H H D D D

2971 D H D D D D H H D D

2972 D H D D D H D H D D

2973 D H D D D H H D D D

2974 D H D D H D D H D D

2975 D H D D H D H D D D

2976 D H D D H H D D D D

2977 D H D D D D D H D D

2978 D H D D D D H D D D

2979 D H D D D H D D D D

2980 D H D D H D D D D D

2981 D H D D D D D D D D

2982 H D D H D H H H D D

2983 H D D H H D H H D D

2984 H D D H H H D H D D

2985 H D D H H H H D D D

2986 H D D H D D H H D D

2987 H D D H D H D H D D

2988 H D D H D H H D D D

2989 H D D H H D D H D D

2990 H D D H H D H D D D

2991 H D D H H H D D D D

2992 H D D H D D D H D D

2993 H D D H D D H D D D

2994 H D D H D H D D D D

2995 H D D H H D D D D D

2996 H D D H D D D D D D

2997 H D H D D H H H D D

2998 H D H D H D H H D D

2999 H D H D H H D H D D

3000 H D H D H H H D D D

3001 H D H D D D H H D D

3002 H D H D D H D H D D

3003 H D H D D H H D D D

3004 H D H D H D D H D D

3005 H D H D H D H D D D

3006 H D H D H H D D D D

3007 H D H D D D D H D D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

3008 H D H D D D H D D D

3009 H D H D D H D D D D

3010 H D H D H D D D D D

301 1 H D H D D D D D D D

3012 H D D D D H H H D D

3013 H D D D H D H H D D

3014 H D D D H H D H D D

3015 H D D D H H H D D D

3016 H D D D D D H H D D

3017 H D D D D H D H D D

3018 H D D D D H H D D D

3019 H D D D H D D H D D

3020 H D D D H D H D D D

3021 H D D D H H D D D D

3022 H D D D D D D H D D

3023 H D D D D D H D D D

3024 H D D D D H D D D D

3025 H D D D H D D D D D

3026 H D D D D D D D D D

3027 D D D H D H H H D D

3028 D D D H H D H H D D

3029 D D D H H H D H D D

3030 D D D H H H H D D D

3031 D D D H D D H H D D

3032 D D D H D H D H D D

3033 D D D H D H H D D D

3034 D D D H H D D H D D

3035 D D D H H D H D D D

3036 D D D H H H D D D D

3037 D D D H D D D H D D

3038 D D D H D D H D D D

3039 D D D H D H D D D D

3040 D D D H H D D D D D

3041 D D D H D D D D D D

3042 D D H D D H H H D D

3043 D D H D H D H H D D

3044 D D H D H H D H D D

3045 D D H D H H H D D D

3046 D D H D D D H H D D

3047 D D H D D H D H D D

3048 D D H D D H H D D D

3049 D D H D H D D H D D

3050 D D H D H D H D D D

3051 D D H D H H D D D D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^y|>/R^y|>' _Rxa _Rxb _Rxb^< _Rxc R^ya/R^ya R^yl,/R^yb'

3052 D D H D D D D H D D

3053 D D H D D D H D D D

3054 D D H D D H D D D D

3055 D D H D H D D D D D

3056 D D H D D D D D D D

3057 D D D D D H H H D D

3058 D D D D H D H H D D

3059 D D D D H H D H D D

3060 D D D D H H H D D D

3061 D D D D D D H H D D

3062 D D D D D H D H D D

3063 D D D D D H H D D D

3064 D D D D H D D H D D

3065 D D D D H D H D D D

3066 D D D D H H D D D D

3067 D D D D D D D H D D

3068 D D D D D D H D D D

3069 D D D D D H D D D D

3070 D D D D H D D D D D

3071 D D D D D D D D D D

Table 4. Compounds of Formulae Il-a, Il-b, II-c, and Il-d wherein each of R⁶, R⁶ , R⁷ and R⁷ is deuterium.

3178 H H H D H H H D H H

3179 H H H D D D H H H H

3180 H H H D D H D H H H

3181 H H H D D H H D H H

3182 H H H D H D D H H H

3183 H H H D H D H D H H

3184 H H H D H H D D H H

3185 H H H D D D D H H H

3186 H H H D D D H D H H

3187 H H H D D H D D H H

3188 H H H D H D D D H H

3189 H H H D D D D D H H

3190 H H D D D H H H H H

3191 H H D D H D H H H H

3192 H H D D H H D H H H

3193 H H D D H H H D H H

3194 H H D D D D H H H H

3195 H H D D D H D H H H

3196 H H D D D H H D H H

3197 H H D D H D D H H H

3198 H H D D H D H D H H

3199 H H D D H H D D H H

3200 H H D D D D D H H H

3201 H H D D D D H D H H

3202 H H D D D H D D H H

3203 H H D D H D D D H H

3204 H H D D D D D D H H

3205 H H D H H H H H D H

3206 H H D H H H H H H D

3207 H H D H H H H H D D

3208 H H H D H H H H D H

3209 H H H D H H H H H D

3210 H H H D H H H H D D

3211 H H D D H H H H D H

3212 H H D D H H H H H D

3213 H H D D H H H H D D

3214 H H H H D H H H D H

3215 H H H H H D H H D H

3216 H H H H H H D H D H

3217 H H H H H H H D D H

3218 H H H H D D H H D H

3219 H H H H D H D H D H

3220 H H H H D H H D D H

3221 H H H H H D D H D H No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

3222 H H H H H D H D D H

3223 H H H H H H D D D H

3224 H H H H D D D H D H

3225 H H H H D D H D D H

3226 H H H H D H D D D H

3227 H H H H H D D D D H

3228 H H H H D D D D D H

3229 H H H H D H H H H D

3230 H H H H H D H H H D

3231 H H H H H H D H H D

3232 H H H H H H H D H D

3233 H H H H D D H H H D

3234 H H H H D H D H H D

3235 H H H H D H H D H D

3236 H H H H H D D H H D

3237 H H H H H D H D H D

3238 H H H H H H D D H D

3239 H H H H D D D H H D

3240 H H H H D D H D H D

3241 H H H H D H D D H D

3242 H H H H H D D D H D

3243 H H H H D D D D H D

3244 H H H H D H H H D D

3245 H H H H H D H H D D

3246 H H H H H H D H D D

3247 H H H H H H H D D D

3248 H H H H D D H H D D

3249 H H H H D H D H D D

3250 H H H H D H H D D D

3251 H H H H H D D H D D

3252 H H H H H D H D D D

3253 H H H H H H D D D D

3254 H H H H D D D H D D

3255 H H H H D D H D D D

3256 H H H H D H D D D D

3257 H H H H H D D D D D

3258 H H H H D D D D D D

3259 D H D H D H H H H H

3260 D H D H H D H H H H

3261 D H D H H H D H H H

3262 D H D H H H H D H H

3263 D H D H D D H H H H

3264 D H D H D H D H H H

3265 D H D H D H H D H H No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

3266 D H D H H D D H H H

3267 D H D H H D H D H H

3268 D H D H H H D D H H

3269 D H D H D D D H H H

3270 D H D H D D H D H H

3271 D H D H D H D D H H

3272 D H D H H D D D H H

3273 D H D H D D D D H H

3274 D H H D D H H H H H

3275 D H H D H D H H H H

3276 D H H D H H D H H H

3277 D H H D H H H D H H

3278 D H H D D D H H H H

3279 D H H D D H D H H H

3280 D H H D D H H D H H

3281 D H H D H D D H H H

3282 D H H D H D H D H H

3283 D H H D H H D D H H

3284 D H H D D D D H H H

3285 D H H D D D H D H H

3286 D H H D D H D D H H

3287 D H H D H D D D H H

3288 D H H D D D D D H H

3289 D H D D D H H H H H

3290 D H D D H D H H H H

3291 D H D D H H D H H H

3292 D H D D H H H D H H

3293 D H D D D D H H H H

3294 D H D D D H D H H H

3295 D H D D D H H D H H

3296 D H D D H D D H H H

3297 D H D D H D H D H H

3298 D H D D H H D D H H

3299 D H D D D D D H H H

3300 D H D D D D H D H H

3301 D H D D D H D D H H

3302 D H D D H D D D H H

3303 D H D D D D D D H H

3304 H D D H D H H H H H

3305 H D D H H D H H H H

3306 H D D H H H D H H H

3307 H D D H H H H D H H

3308 H D D H D D H H H H

3309 H D D H D H D H H H No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

3310 H D D H D H H D H H

331 1 H D D H H D D H H H

3312 H D D H H D H D H H

3313 H D D H H H D D H H

3314 H D D H D D D H H H

3315 H D D H D D H D H H

3316 H D D H D H D D H H

3317 H D D H H D D D H H

3318 H D D H D D D D H H

3319 H D H D D H H H H H

3320 H D H D H D H H H H

3321 H D H D H H D H H H

3322 H D H D H H H D H H

3323 H D H D D D H H H H

3324 H D H D D H D H H H

3325 H D H D D H H D H H

3326 H D H D H D D H H H

3327 H D H D H D H D H H

3328 H D H D H H D D H H

3329 H D H D D D D H H H

3330 H D H D D D H D H H

3331 H D H D D H D D H H

3332 H D H D H D D D H H

3333 H D H D D D D D H H

3334 H D D D D H H H H H

3335 H D D D H D H H H H

3336 H D D D H H D H H H

3337 H D D D H H H D H H

3338 H D D D D D H H H H

3339 H D D D D H D H H H

3340 H D D D D H H D H H

3341 H D D D H D D H H H

3342 H D D D H D H D H H

3343 H D D D H H D D H H

3344 H D D D D D D H H H

3345 H D D D D D H D H H

3346 H D D D D H D D H H

3347 H D D D H D D D H H

3348 H D D D D D D D H H

3349 D D D H D H H H H H

3350 D D D H H D H H H H

3351 D D D H H H D H H H

3352 D D D H H H H D H H

3353 D D D H D D H H H H No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

3354 D D D H D H D H H H

3355 D D D H D H H D H H

3356 D D D H H D D H H H

3357 D D D H H D H D H H

3358 D D D H H H D D H H

3359 D D D H D D D H H H

3360 D D D H D D H D H H

3361 D D D H D H D D H H

3362 D D D H H D D D H H

3363 D D D H D D D D H H

3364 D D H D D H H H H H

3365 D D H D H D H H H H

3366 D D H D H H D H H H

3367 D D H D H H H D H H

3368 D D H D D D H H H H

3369 D D H D D H D H H H

3370 D D H D D H H D H H

3371 D D H D H D D H H H

3372 D D H D H D H D H H

3373 D D H D H H D D H H

3374 D D H D D D D H H H

3375 D D H D D D H D H H

3376 D D H D D H D D H H

3377 D D H D H D D D H H

3378 D D H D D D D D H H

3379 D D D D D H H H H H

3380 D D D D H D H H H H

3381 D D D D H H D H H H

3382 D D D D H H H D H H

3383 D D D D D D H H H H

3384 D D D D D H D H H H

3385 D D D D D H H D H H

3386 D D D D H D D H H H

3387 D D D D H D H D H H

3388 D D D D H H D D H H

3389 D D D D D D D H H H

3390 D D D D D D H D H H

3391 D D D D D H D D H H

3392 D D D D H D D D H H

3393 D D D D D D D D H H

3394 D H D H H H H H D H

3395 D H H D H H H H D H

3396 D H D D H H H H D H

3397 H D D H H H H H D H

3530 D D H H D D H H H D

3531 D D H H D H D H H D

3532 D D H H D H H D H D

3533 D D H H H D D H H D

3534 D D H H H D H D H D

3535 D D H H H H D D H D

3536 D D H H D D D H H D

3537 D D H H D D H D H D

3538 D D H H D H D D H D

3539 D D H H H D D D H D

3540 D D H H D D D D H D

3541 D D H H D H H H D D

3542 D D H H H D H H D D

3543 D D H H H H D H D D

3544 D D H H H H H D D D

3545 D D H H D D H H D D

3546 D D H H D H D H D D

3547 D D H H D H H D D D

3548 D D H H H D D H D D

3549 D D H H H D H D D D

3550 D D H H H H D D D D

3551 D D H H D D D H D D

3552 D D H H D D H D D D

3553 D D H H D H D D D D

3554 D D H H H D D D D D

3555 D D H H D D D D D D

3556 H H D H D H H H D H

3557 H H D H H D H H D H

3558 H H D H H H D H D H

3559 H H D H H H H D D H

3560 H H D H D D H H D H

3561 H H D H D H D H D H

3562 H H D H D H H D D H

3563 H H D H H D D H D H

3564 H H D H H D H D D H

3565 H H D H H H D D D H

3566 H H D H D D D H D H

3567 H H D H D D H D D H

3568 H H D H D H D D D H

3569 H H D H H D D D D H

3570 H H D H D D D D D H

3571 H H D H D H H H H D

3572 H H D H H D H H H D

3573 H H D H H H D H H D No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

3574 H H D H H H H D H D

3575 H H D H D D H H H D

3576 H H D H D H D H H D

3577 H H D H D H H D H D

3578 H H D H H D D H H D

3579 H H D H H D H D H D

3580 H H D H H H D D H D

3581 H H D H D D D H H D

3582 H H D H D D H D H D

3583 H H D H D H D D H D

3584 H H D H H D D D H D

3585 H H D H D D D D H D

3586 H H D H D H H H D D

3587 H H D H H D H H D D

3588 H H D H H H D H D D

3589 H H D H H H H D D D

3590 H H D H D D H H D D

3591 H H D H D H D H D D

3592 H H D H D H H D D D

3593 H H D H H D D H D D

3594 H H D H H D H D D D

3595 H H D H H H D D D D

3596 H H D H D D D H D D

3597 H H D H D D H D D D

3598 H H D H D H D D D D

3599 H H D H H D D D D D

3600 H H D H D D D D D D

3601 H H H D D H H H D H

3602 H H H D H D H H D H

3603 H H H D H H D H D H

3604 H H H D H H H D D H

3605 H H H D D D H H D H

3606 H H H D D H D H D H

3607 H H H D D H H D D H

3608 H H H D H D D H D H

3609 H H H D H D H D D H

3610 H H H D H H D D D H

361 1 H H H D D D D H D H

3612 H H H D D D H D D H

3613 H H H D D H D D D H

3614 H H H D H D D D D H

3615 H H H D D D D D D H

3616 H H H D D H H H H D

3617 H H H D H D H H H D

3662 H H D D H D H H H D

3663 H H D D H H D H H D

3664 H H D D H H H D H D

3665 H H D D D D H H H D

3666 H H D D D H D H H D

3667 H H D D D H H D H D

3668 H H D D H D D H H D

3669 H H D D H D H D H D

3670 H H D D H H D D H D

3671 H H D D D D D H H D

3672 H H D D D D H D H D

3673 H H D D D H D D H D

3674 H H D D H D D D H D

3675 H H D D D D D D H D

3676 H H D D D H H H D D

3677 H H D D H D H H D D

3678 H H D D H H D H D D

3679 H H D D H H H D D D

3680 H H D D D D H H D D

3681 H H D D D H D H D D

3682 H H D D D H H D D D

3683 H H D D H D D H D D

3684 H H D D H D H D D D

3685 H H D D H H D D D D

3686 H H D D D D D H D D

3687 H H D D D D H D D D

3688 H H D D D H D D D D

3689 H H D D H D D D D D

3690 H H D D D D D D D D

3691 D H D H D H H H D H

3692 D H D H H D H H D H

3693 D H D H H H D H D H

3694 D H D H H H H D D H

3695 D H D H D D H H D H

3696 D H D H D H D H D H

3697 D H D H D H H D D H

3698 D H D H H D D H D H

3699 D H D H H D H D D H

3700 D H D H H H D D D H

3701 D H D H D D D H D H

3702 D H D H D D H D D H

3703 D H D H D H D D D H

3704 D H D H H D D D D H

3705 D H D H D D D D D H No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

3706 D H H D D H H H D H

3707 D H H D H D H H D H

3708 D H H D H H D H D H

3709 D H H D H H H D D H

3710 D H H D D D H H D H

371 1 D H H D D H D H D H

3712 D H H D D H H D D H

3713 D H H D H D D H D H

3714 D H H D H D H D D H

3715 D H H D H H D D D H

3716 D H H D D D D H D H

3717 D H H D D D H D D H

3718 D H H D D H D D D H

3719 D H H D H D D D D H

3720 D H H D D D D D D H

3721 D H D D D H H H D H

3722 D H D D H D H H D H

3723 D H D D H H D H D H

3724 D H D D H H H D D H

3725 D H D D D D H H D H

3726 D H D D D H D H D H

3727 D H D D D H H D D H

3728 D H D D H D D H D H

3729 D H D D H D H D D H

3730 D H D D H H D D D H

3731 D H D D D D D H D H

3732 D H D D D D H D D H

3733 D H D D D H D D D H

3734 D H D D H D D D D H

3735 D H D D D D D D D H

3736 H D D H D H H H D H

3737 H D D H H D H H D H

3738 H D D H H H D H D H

3739 H D D H H H H D D H

3740 H D D H D D H H D H

3741 H D D H D H D H D H

3742 H D D H D H H D D H

3743 H D D H H D D H D H

3744 H D D H H D H D D H

3745 H D D H H H D D D H

3746 H D D H D D D H D H

3747 H D D H D D H D D H

3748 H D D H D H D D D H

3749 H D D H H D D D D H No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

3750 H D D H D D D D D H

3751 H D H D D H H H D H

3752 H D H D H D H H D H

3753 H D H D H H D H D H

3754 H D H D H H H D D H

3755 H D H D D D H H D H

3756 H D H D D H D H D H

3757 H D H D D H H D D H

3758 H D H D H D D H D H

3759 H D H D H D H D D H

3760 H D H D H H D D D H

3761 H D H D D D D H D H

3762 H D H D D D H D D H

3763 H D H D D H D D D H

3764 H D H D H D D D D H

3765 H D H D D D D D D H

3766 H D D D D H H H D H

3767 H D D D H D H H D H

3768 H D D D H H D H D H

3769 H D D D H H H D D H

3770 H D D D D D H H D H

3771 H D D D D H D H D H

3772 H D D D D H H D D H

3773 H D D D H D D H D H

3774 H D D D H D H D D H

3775 H D D D H H D D D H

3776 H D D D D D D H D H

3777 H D D D D D H D D H

3778 H D D D D H D D D H

3779 H D D D H D D D D H

3780 H D D D D D D D D H

3781 D D D H D H H H D H

3782 D D D H H D H H D H

3783 D D D H H H D H D H

3784 D D D H H H H D D H

3785 D D D H D D H H D H

3786 D D D H D H D H D H

3787 D D D H D H H D D H

3788 D D D H H D D H D H

3789 D D D H H D H D D H

3790 D D D H H H D D D H

3791 D D D H D D D H D H

3792 D D D H D D H D D H

3793 D D D H D H D D D H

3882 H D D H D D H D H D

3883 H D D H D H D D H D

3884 H D D H H D D D H D

3885 H D D H D D D D H D

3886 H D H D D H H H H D

3887 H D H D H D H H H D

3888 H D H D H H D H H D

3889 H D H D H H H D H D

3890 H D H D D D H H H D

3891 H D H D D H D H H D

3892 H D H D D H H D H D

3893 H D H D H D D H H D

3894 H D H D H D H D H D

3895 H D H D H H D D H D

3896 H D H D D D D H H D

3897 H D H D D D H D H D

3898 H D H D D H D D H D

3899 H D H D H D D D H D

3900 H D H D D D D D H D

3901 H D D D D H H H H D

3902 H D D D H D H H H D

3903 H D D D H H D H H D

3904 H D D D H H H D H D

3905 H D D D D D H H H D

3906 H D D D D H D H H D

3907 H D D D D H H D H D

3908 H D D D H D D H H D

3909 H D D D H D H D H D

3910 H D D D H H D D H D

391 1 H D D D D D D H H D

3912 H D D D D D H D H D

3913 H D D D D H D D H D

3914 H D D D H D D D H D

3915 H D D D D D D D H D

3916 D D D H D H H H H D

3917 D D D H H D H H H D

3918 D D D H H H D H H D

3919 D D D H H H H D H D

3920 D D D H D D H H H D

3921 D D D H D H D H H D

3922 D D D H D H H D H D

3923 D D D H H D D H H D

3924 D D D H H D H D H D

3925 D D D H H H D D H D No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

3926 D D D H D D D H H D

3927 D D D H D D H D H D

3928 D D D H D H D D H D

3929 D D D H H D D D H D

3930 D D D H D D D D H D

3931 D D H D D H H H H D

3932 D D H D H D H H H D

3933 D D H D H H D H H D

3934 D D H D H H H D H D

3935 D D H D D D H H H D

3936 D D H D D H D H H D

3937 D D H D D H H D H D

3938 D D H D H D D H H D

3939 D D H D H D H D H D

3940 D D H D H H D D H D

3941 D D H D D D D H H D

3942 D D H D D D H D H D

3943 D D H D D H D D H D

3944 D D H D H D D D H D

3945 D D H D D D D D H D

3946 D D D D D H H H H D

3947 D D D D H D H H H D

3948 D D D D H H D H H D

3949 D D D D H H H D H D

3950 D D D D D D H H H D

3951 D D D D D H D H H D

3952 D D D D D H H D H D

3953 D D D D H D D H H D

3954 D D D D H D H D H D

3955 D D D D H H D D H D

3956 D D D D D D D H H D

3957 D D D D D D H D H D

3958 D D D D D H D D H D

3959 D D D D H D D D H D

3960 D D D D D D D D H D

3961 D H D H D H H H D D

3962 D H D H H D H H D D

3963 D H D H H H D H D D

3964 D H D H H H H D D D

3965 D H D H D D H H D D

3966 D H D H D H D H D D

3967 D H D H D H H D D D

3968 D H D H H D D H D D

3969 D H D H H D H D D D No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

3970 D H D H H H D D D D

3971 D H D H D D D H D D

3972 D H D H D D H D D D

3973 D H D H D H D D D D

3974 D H D H H D D D D D

3975 D H D H D D D D D D

3976 D H H D D H H H D D

3977 D H H D H D H H D D

3978 D H H D H H D H D D

3979 D H H D H H H D D D

3980 D H H D D D H H D D

3981 D H H D D H D H D D

3982 D H H D D H H D D D

3983 D H H D H D D H D D

3984 D H H D H D H D D D

3985 D H H D H H D D D D

3986 D H H D D D D H D D

3987 D H H D D D H D D D

3988 D H H D D H D D D D

3989 D H H D H D D D D D

3990 D H H D D D D D D D

3991 D H D D D H H H D D

3992 D H D D H D H H D D

3993 D H D D H H D H D D

3994 D H D D H H H D D D

3995 D H D D D D H H D D

3996 D H D D D H D H D D

3997 D H D D D H H D D D

3998 D H D D H D D H D D

3999 D H D D H D H D D D

4000 D H D D H H D D D D

4001 D H D D D D D H D D

4002 D H D D D D H D D D

4003 D H D D D H D D D D

4004 D H D D H D D D D D

4005 D H D D D D D D D D

4006 H D D H D H H H D D

4007 H D D H H D H H D D

4008 H D D H H H D H D D

4009 H D D H H H H D D D

4010 H D D H D D H H D D

401 1 H D D H D H D H D D

4012 H D D H D H H D D D

4013 H D D H H D D H D D

4058 D D D H H D D H D D

4059 D D D H H D H D D D

4060 D D D H H H D D D D

4061 D D D H D D D H D D

4062 D D D H D D H D D D

4063 D D D H D H D D D D

4064 D D D H H D D D D D

4065 D D D H D D D D D D

4066 D D H D D H H H D D

4067 D D H D H D H H D D

4068 D D H D H H D H D D

4069 D D H D H H H D D D

4070 D D H D D D H H D D

4071 D D H D D H D H D D

4072 D D H D D H H D D D

4073 D D H D H D D H D D

4074 D D H D H D H D D D

4075 D D H D H H D D D D

4076 D D H D D D D H D D

4077 D D H D D D H D D D

4078 D D H D D H D D D D

4079 D D H D H D D D D D

4080 D D H D D D D D D D

4081 D D D D D H H H D D

4082 D D D D H D H H D D

4083 D D D D H H D H D D

4084 D D D D H H H D D D

4085 D D D D D D H H D D

4086 D D D D D H D H D D

4087 D D D D D H H D D D

4088 D D D D H D D H D D

4089 D D D D H D H D D D

4090 D D D D H H D D D D

4091 D D D D D D D H D D

4092 D D D D D D H D D D

4093 D D D D D H D D D D

4094 D D D D H D D D D D

4095 D D D D D D D D D D

[0041] Table 5 sets forth compounds of Formula Ill-a, Ill-b, III-c, and Ill-d wherein each of R⁶, R⁶, R⁷ and R⁷ is hydrogen. Table 6 sets forth compounds of Formula Ill-a, Ill-b, III-c, and Ill-d wherein each of R⁶ and R⁶ is hydrogen and each of R⁷ and R⁷ is deuterium. Table 7 sets forth compounds of Formula Ill-a, Ill-b, III-c, and ΠΙ-d wherein each of R⁶ and R⁶ is deuterium and each of R⁷ and R⁷ is hydrogen. Table 8 sets forth compounds of Formula Ill-a, Ill-b, III-c, and Ill-d wherein each of R⁶, R⁶, R⁷ and R⁷ is deuterium. It will be appreciated that each row in Table 5, Table 6, Table 7, and Table 8 represents four discrete compounds. For example, row 2 in Table 5 represents compounds ni-a-2, III-b-2, III-c-2 and III-d-2:

III-a-2 III-b-2 III-c-2 III-d-2

Table 5. Compounds of Formulae Ill-a, Ill-b, III-c, and Ill-d wherein each of R⁶, R⁶ , R⁷ and R⁷ is hydrogen.

R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

H H H H H D D D H H

H H H H D D D D H H

H H H H H H H H D H

H H H H H H H H H D

H H H H H H H H D D

D H D H H H H H H H

D H H D H H H H H H

D H D D H H H H H H

H D D H H H H H H H

H D H D H H H H H H

H D D D H H H H H H

D D D H H H H H H H

D D H D H H H H H H

D D D D H H H H H H

D H H H D H H H H H

D H H H H D H H H H

D H H H H H D H H H

D H H H H H H D H H

D H H H D D H H H H

D H H H D H D H H H

D H H H D H H D H H

D H H H H D D H H H

D H H H H D H D H H

D H H H H H D D H H

D H H H D D D H H H

D H H H D D H D H H

D H H H D H D D H H

D H H H H D D D H H

D H H H D D D D H H

H D H H D H H H H H

H D H H H D H H H H

H D H H H H D H H H

H D H H H H H D H H

H D H H D D H H H H

H D H H D H D H H H

H D H H D H H D H H

H D H H H D D H H H

H D H H H D H D H H

H D H H H H D D H H

H D H H D D D H H H

H D H H D D H D H H

H D H H D H D D H H

H D H H H D D D H H

H D H H D D D D H H R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

D D H H D H H H H H

D D H H H D H H H H

D D H H H H D H H H

D D H H H H H D H H

D D H H D D H H H H

D D H H D H D H H H

D D H H D H H D H H

D D H H H D D H H H

D D H H H D H D H H

D D H H H H D D H H

D D H H D D D H H H

D D H H D D H D H H

D D H H D H D D H H

D D H H H D D D H H

D D H H D D D D H H

D H H H H H H H D H

D H H H H H H H H D

D H H H H H H H D D

H D H H H H H H D H

H D H H H H H H H D

H D H H H H H H D D

D D H H H H H H D H

D D H H H H H H H D

D D H H H H H H D D

H H D H D H H H H H

H H D H H D H H H H

H H D H H H D H H H

H H D H H H H D H H

H H D H D D H H H H

H H D H D H D H H H

H H D H D H H D H H

H H D H H D D H H H

H H D H H D H D H H

H H D H H H D D H H

H H D H D D D H H H

H H D H D D H D H H

H H D H D H D D H H

H H D H H D D D H H

H H D H D D D D H H

H H H D D H H H H H

H H H D H D H H H H

H H H D H H D H H H

H H H D H H H D H H

H H H D D D H H H H o. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

109 H H H D D H D H H H

110 H H H D D H H D H H

111 H H H D H D D H H H

112 H H H D H D H D H H

113 H H H D H H D D H H

114 H H H D D D D H H H

115 H H H D D D H D H H

116 H H H D D H D D H H

117 H H H D H D D D H H

118 H H H D D D D D H H

119 H H D D D H H H H H

120 H H D D H D H H H H

121 H H D D H H D H H H

122 H H D D H H H D H H

123 H H D D D D H H H H

124 H H D D D H D H H H

125 H H D D D H H D H H

126 H H D D H D D H H H

127 H H D D H D H D H H

128 H H D D H H D D H H

129 H H D D D D D H H H

130 H H D D D D H D H H

131 H H D D D H D D H H

132 H H D D H D D D H H

133 H H D D D D D D H H

134 H H D H H H H H D H

135 H H D H H H H H H D

136 H H D H H H H H D D

137 H H H D H H H H D H

138 H H H D H H H H H D

139 H H H D H H H H D D

140 H H D D H H H H D H

141 H H D D H H H H H D

142 H H D D H H H H D D

143 H H H H D H H H D H

144 H H H H H D H H D H

145 H H H H H H D H D H

146 H H H H H H H D D H

147 H H H H D D H H D H

148 H H H H D H D H D H

149 H H H H D H H D D H

150 H H H H H D D H D H

151 H H H H H D H D D H

152 H H H H H H D D D H o. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

153 H H H H D D D H D H

154 H H H H D D H D D H

155 H H H H D H D D D H

156 H H H H H D D D D H

157 H H H H D D D D D H

158 H H H H D H H H H D

159 H H H H H D H H H D

160 H H H H H H D H H D

161 H H H H H H H D H D

162 H H H H D D H H H D

163 H H H H D H D H H D

164 H H H H D H H D H D

165 H H H H H D D H H D

166 H H H H H D H D H D

167 H H H H H H D D H D

168 H H H H D D D H H D

169 H H H H D D H D H D

170 H H H H D H D D H D

171 H H H H H D D D H D

172 H H H H D D D D H D

173 H H H H D H H H D D

174 H H H H H D H H D D

175 H H H H H H D H D D

176 H H H H H H H D D D

177 H H H H D D H H D D

178 H H H H D H D H D D

179 H H H H D H H D D D

180 H H H H H D D H D D

181 H H H H H D H D D D

182 H H H H H H D D D D

183 H H H H D D D H D D

184 H H H H D D H D D D

185 H H H H D H D D D D

186 H H H H H D D D D D

187 H H H H D D D D D D

188 D H D H D H H H H H

189 D H D H H D H H H H

190 D H D H H H D H H H

191 D H D H H H H D H H

192 D H D H D D H H H H

193 D H D H D H D H H H

194 D H D H D H H D H H

195 D H D H H D D H H H

196 D H D H H D H D H H No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

197 D H D H H H D D H H

198 D H D H D D D H H H

199 D H D H D D H D H H

200 D H D H D H D D H H

201 D H D H H D D D H H

202 D H D H D D D D H H

203 D H H D D H H H H H

204 D H H D H D H H H H

205 D H H D H H D H H H

206 D H H D H H H D H H

207 D H H D D D H H H H

208 D H H D D H D H H H

209 D H H D D H H D H H

210 D H H D H D D H H H

211 D H H D H D H D H H

212 D H H D H H D D H H

213 D H H D D D D H H H

214 D H H D D D H D H H

215 D H H D D H D D H H

216 D H H D H D D D H H

217 D H H D D D D D H H

218 D H D D D H H H H H

219 D H D D H D H H H H

220 D H D D H H D H H H

221 D H D D H H H D H H

222 D H D D D D H H H H

223 D H D D D H D H H H

224 D H D D D H H D H H

225 D H D D H D D H H H

226 D H D D H D H D H H

227 D H D D H H D D H H

228 D H D D D D D H H H

229 D H D D D D H D H H

230 D H D D D H D D H H

231 D H D D H D D D H H

232 D H D D D D D D H H

233 H D D H D H H H H H

234 H D D H H D H H H H

235 H D D H H H D H H H

236 H D D H H H H D H H

237 H D D H D D H H H H

238 H D D H D H D H H H

239 H D D H D H H D H H

240 H D D H H D D H H H No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

241 H D D H H D H D H H

242 H D D H H H D D H H

243 H D D H D D D H H H

244 H D D H D D H D H H

245 H D D H D H D D H H

246 H D D H H D D D H H

247 H D D H D D D D H H

248 H D H D D H H H H H

249 H D H D H D H H H H

250 H D H D H H D H H H

251 H D H D H H H D H H

252 H D H D D D H H H H

253 H D H D D H D H H H

254 H D H D D H H D H H

255 H D H D H D D H H H

256 H D H D H D H D H H

257 H D H D H H D D H H

258 H D H D D D D H H H

259 H D H D D D H D H H

260 H D H D D H D D H H

261 H D H D H D D D H H

262 H D H D D D D D H H

263 H D D D D H H H H H

264 H D D D H D H H H H

265 H D D D H H D H H H

266 H D D D H H H D H H

267 H D D D D D H H H H

268 H D D D D H D H H H

269 H D D D D H H D H H

270 H D D D H D D H H H

271 H D D D H D H D H H

272 H D D D H H D D H H

273 H D D D D D D H H H

274 H D D D D D H D H H

275 H D D D D H D D H H

276 H D D D H D D D H H

277 H D D D D D D D H H

278 D D D H D H H H H H

279 D D D H H D H H H H

280 D D D H H H D H H H

281 D D D H H H H D H H

282 D D D H D D H H H H

283 D D D H D H D H H H

284 D D D H D H H D H H No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

285 D D D H H D D H H H

286 D D D H H D H D H H

287 D D D H H H D D H H

288 D D D H D D D H H H

289 D D D H D D H D H H

290 D D D H D H D D H H

291 D D D H H D D D H H

292 D D D H D D D D H H

293 D D H D D H H H H H

294 D D H D H D H H H H

295 D D H D H H D H H H

296 D D H D H H H D H H

297 D D H D D D H H H H

298 D D H D D H D H H H

299 D D H D D H H D H H

300 D D H D H D D H H H

301 D D H D H D H D H H

302 D D H D H H D D H H

303 D D H D D D D H H H

304 D D H D D D H D H H

305 D D H D D H D D H H

306 D D H D H D D D H H

307 D D H D D D D D H H

308 D D D D D H H H H H

309 D D D D H D H H H H

310 D D D D H H D H H H

311 D D D D H H H D H H

312 D D D D D D H H H H

313 D D D D D H D H H H

314 D D D D D H H D H H

315 D D D D H D D H H H

316 D D D D H D H D H H

317 D D D D H H D D H H

318 D D D D D D D H H H

319 D D D D D D H D H H

320 D D D D D H D D H H

321 D D D D H D D D H H

322 D D D D D D D D H H

323 D H D H H H H H D H

324 D H H D H H H H D H

325 D H D D H H H H D H

326 H D D H H H H H D H

327 H D H D H H H H D H

328 H D D D H H H H D H No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

329 D D D H H H H H D H

330 D D H D H H H H D H

331 D D D D H H H H D H

332 D H D H H H H H H D

333 D H H D H H H H H D

334 D H D D H H H H H D

335 H D D H H H H H H D

336 H D H D H H H H H D

337 H D D D H H H H H D

338 D D D H H H H H H D

339 D D H D H H H H H D

340 D D D D H H H H H D

341 D H D H H H H H D D

342 D H H D H H H H D D

343 D H D D H H H H D D

344 H D D H H H H H D D

345 H D H D H H H H D D

346 H D D D H H H H D D

347 D D D H H H H H D D

348 D D H D H H H H D D

349 D D D D H H H H D D

350 D H H H D H H H D H

351 D H H H H D H H D H

352 D H H H H H D H D H

353 D H H H H H H D D H

354 D H H H D D H H D H

355 D H H H D H D H D H

356 D H H H D H H D D H

357 D H H H H D D H D H

358 D H H H H D H D D H

359 D H H H H H D D D H

360 D H H H D D D H D H

361 D H H H D D H D D H

362 D H H H D H D D D H

363 D H H H H D D D D H

364 D H H H D D D D D H

365 D H H H D H H H H D

366 D H H H H D H H H D

367 D H H H H H D H H D

368 D H H H H H H D H D

369 D H H H D D H H H D

370 D H H H D H D H H D

371 D H H H D H H D H D

372 D H H H H D D H H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

373 D H H H H D H D H D

374 D H H H H H D D H D

375 D H H H D D D H H D

376 D H H H D D H D H D

377 D H H H D H D D H D

378 D H H H H D D D H D

379 D H H H D D D D H D

380 D H H H D H H H D D

381 D H H H H D H H D D

382 D H H H H H D H D D

383 D H H H H H H D D D

384 D H H H D D H H D D

385 D H H H D H D H D D

386 D H H H D H H D D D

387 D H H H H D D H D D

388 D H H H H D H D D D

389 D H H H H H D D D D

390 D H H H D D D H D D

391 D H H H D D H D D D

392 D H H H D H D D D D

393 D H H H H D D D D D

394 D H H H D D D D D D

395 H D H H D H H H D H

396 H D H H H D H H D H

397 H D H H H H D H D H

398 H D H H H H H D D H

399 H D H H D D H H D H

400 H D H H D H D H D H

401 H D H H D H H D D H

402 H D H H H D D H D H

403 H D H H H D H D D H

404 H D H H H H D D D H

405 H D H H D D D H D H

406 H D H H D D H D D H

407 H D H H D H D D D H

408 H D H H H D D D D H

409 H D H H D D D D D H

410 H D H H D H H H H D

411 H D H H H D H H H D

412 H D H H H H D H H D

413 H D H H H H H D H D

414 H D H H D D H H H D

415 H D H H D H D H H D

416 H D H H D H H D H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

417 H D H H H D D H H D

418 H D H H H D H D H D

419 H D H H H H D D H D

420 H D H H D D D H H D

421 H D H H D D H D H D

422 H D H H D H D D H D

423 H D H H H D D D H D

424 H D H H D D D D H D

425 H D H H D H H H D D

426 H D H H H D H H D D

427 H D H H H H D H D D

428 H D H H H H H D D D

429 H D H H D D H H D D

430 H D H H D H D H D D

431 H D H H D H H D D D

432 H D H H H D D H D D

433 H D H H H D H D D D

434 H D H H H H D D D D

435 H D H H D D D H D D

436 H D H H D D H D D D

437 H D H H D H D D D D

438 H D H H H D D D D D

439 H D H H D D D D D D

440 D D H H D H H H D H

441 D D H H H D H H D H

442 D D H H H H D H D H

443 D D H H H H H D D H

444 D D H H D D H H D H

445 D D H H D H D H D H

446 D D H H D H H D D H

447 D D H H H D D H D H

448 D D H H H D H D D H

449 D D H H H H D D D H

450 D D H H D D D H D H

451 D D H H D D H D D H

452 D D H H D H D D D H

453 D D H H H D D D D H

454 D D H H D D D D D H

455 D D H H D H H H H D

456 D D H H H D H H H D

457 D D H H H H D H H D

458 D D H H H H H D H D

459 D D H H D D H H H D

460 D D H H D H D H H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

461 D D H H D H H D H D

462 D D H H H D D H H D

463 D D H H H D H D H D

464 D D H H H H D D H D

465 D D H H D D D H H D

466 D D H H D D H D H D

467 D D H H D H D D H D

468 D D H H H D D D H D

469 D D H H D D D D H D

470 D D H H D H H H D D

471 D D H H H D H H D D

472 D D H H H H D H D D

473 D D H H H H H D D D

474 D D H H D D H H D D

475 D D H H D H D H D D

476 D D H H D H H D D D

477 D D H H H D D H D D

478 D D H H H D H D D D

479 D D H H H H D D D D

480 D D H H D D D H D D

481 D D H H D D H D D D

482 D D H H D H D D D D

483 D D H H H D D D D D

484 D D H H D D D D D D

485 H H D H D H H H D H

486 H H D H H D H H D H

487 H H D H H H D H D H

488 H H D H H H H D D H

489 H H D H D D H H D H

490 H H D H D H D H D H

491 H H D H D H H D D H

492 H H D H H D D H D H

493 H H D H H D H D D H

494 H H D H H H D D D H

495 H H D H D D D H D H

496 H H D H D D H D D H

497 H H D H D H D D D H

498 H H D H H D D D D H

499 H H D H D D D D D H

500 H H D H D H H H H D

501 H H D H H D H H H D

502 H H D H H H D H H D

503 H H D H H H H D H D

504 H H D H D D H H H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

505 H H D H D H D H H D

506 H H D H D H H D H D

507 H H D H H D D H H D

508 H H D H H D H D H D

509 H H D H H H D D H D

510 H H D H D D D H H D

511 H H D H D D H D H D

512 H H D H D H D D H D

513 H H D H H D D D H D

514 H H D H D D D D H D

515 H H D H D H H H D D

516 H H D H H D H H D D

517 H H D H H H D H D D

518 H H D H H H H D D D

519 H H D H D D H H D D

520 H H D H D H D H D D

521 H H D H D H H D D D

522 H H D H H D D H D D

523 H H D H H D H D D D

524 H H D H H H D D D D

525 H H D H D D D H D D

526 H H D H D D H D D D

527 H H D H D H D D D D

528 H H D H H D D D D D

529 H H D H D D D D D D

530 H H H D D H H H D H

531 H H H D H D H H D H

532 H H H D H H D H D H

533 H H H D H H H D D H

534 H H H D D D H H D H

535 H H H D D H D H D H

536 H H H D D H H D D H

537 H H H D H D D H D H

538 H H H D H D H D D H

539 H H H D H H D D D H

540 H H H D D D D H D H

541 H H H D D D H D D H

542 H H H D D H D D D H

543 H H H D H D D D D H

544 H H H D D D D D D H

545 H H H D D H H H H D

546 H H H D H D H H H D

547 H H H D H H D H H D

548 H H H D H H H D H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

549 H H H D D D H H H D

550 H H H D D H D H H D

551 H H H D D H H D H D

552 H H H D H D D H H D

553 H H H D H D H D H D

554 H H H D H H D D H D

555 H H H D D D D H H D

556 H H H D D D H D H D

557 H H H D D H D D H D

558 H H H D H D D D H D

559 H H H D D D D D H D

560 H H H D D H H H D D

561 H H H D H D H H D D

562 H H H D H H D H D D

563 H H H D H H H D D D

564 H H H D D D H H D D

565 H H H D D H D H D D

566 H H H D D H H D D D

567 H H H D H D D H D D

568 H H H D H D H D D D

569 H H H D H H D D D D

570 H H H D D D D H D D

571 H H H D D D H D D D

572 H H H D D H D D D D

573 H H H D H D D D D D

574 H H H D D D D D D D

575 H H D D D H H H D H

576 H H D D H D H H D H

577 H H D D H H D H D H

578 H H D D H H H D D H

579 H H D D D D H H D H

580 H H D D D H D H D H

581 H H D D D H H D D H

582 H H D D H D D H D H

583 H H D D H D H D D H

584 H H D D H H D D D H

585 H H D D D D D H D H

586 H H D D D D H D D H

587 H H D D D H D D D H

588 H H D D H D D D D H

589 H H D D D D D D D H

590 H H D D D H H H H D

591 H H D D H D H H H D

592 H H D D H H D H H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

593 H H D D H H H D H D

594 H H D D D D H H H D

595 H H D D D H D H H D

596 H H D D D H H D H D

597 H H D D H D D H H D

598 H H D D H D H D H D

599 H H D D H H D D H D

600 H H D D D D D H H D

601 H H D D D D H D H D

602 H H D D D H D D H D

603 H H D D H D D D H D

604 H H D D D D D D H D

605 H H D D D H H H D D

606 H H D D H D H H D D

607 H H D D H H D H D D

608 H H D D H H H D D D

609 H H D D D D H H D D

610 H H D D D H D H D D

61 1 H H D D D H H D D D

612 H H D D H D D H D D

613 H H D D H D H D D D

614 H H D D H H D D D D

615 H H D D D D D H D D

616 H H D D D D H D D D

617 H H D D D H D D D D

618 H H D D H D D D D D

619 H H D D D D D D D D

620 D H D H D H H H D H

621 D H D H H D H H D H

622 D H D H H H D H D H

623 D H D H H H H D D H

624 D H D H D D H H D H

625 D H D H D H D H D H

626 D H D H D H H D D H

627 D H D H H D D H D H

628 D H D H H D H D D H

629 D H D H H H D D D H

630 D H D H D D D H D H

631 D H D H D D H D D H

632 D H D H D H D D D H

633 D H D H H D D D D H

634 D H D H D D D D D H

635 D H H D D H H H D H

636 D H H D H D H H D H No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

637 D H H D H H D H D H

638 D H H D H H H D D H

639 D H H D D D H H D H

640 D H H D D H D H D H

641 D H H D D H H D D H

642 D H H D H D D H D H

643 D H H D H D H D D H

644 D H H D H H D D D H

645 D H H D D D D H D H

646 D H H D D D H D D H

647 D H H D D H D D D H

648 D H H D H D D D D H

649 D H H D D D D D D H

650 D H D D D H H H D H

651 D H D D H D H H D H

652 D H D D H H D H D H

653 D H D D H H H D D H

654 D H D D D D H H D H

655 D H D D D H D H D H

656 D H D D D H H D D H

657 D H D D H D D H D H

658 D H D D H D H D D H

659 D H D D H H D D D H

660 D H D D D D D H D H

661 D H D D D D H D D H

662 D H D D D H D D D H

663 D H D D H D D D D H

664 D H D D D D D D D H

665 H D D H D H H H D H

666 H D D H H D H H D H

667 H D D H H H D H D H

668 H D D H H H H D D H

669 H D D H D D H H D H

670 H D D H D H D H D H

671 H D D H D H H D D H

672 H D D H H D D H D H

673 H D D H H D H D D H

674 H D D H H H D D D H

675 H D D H D D D H D H

676 H D D H D D H D D H

677 H D D H D H D D D H

678 H D D H H D D D D H

679 H D D H D D D D D H

680 H D H D D H H H D H No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

681 H D H D H D H H D H

682 H D H D H H D H D H

683 H D H D H H H D D H

684 H D H D D D H H D H

685 H D H D D H D H D H

686 H D H D D H H D D H

687 H D H D H D D H D H

688 H D H D H D H D D H

689 H D H D H H D D D H

690 H D H D D D D H D H

691 H D H D D D H D D H

692 H D H D D H D D D H

693 H D H D H D D D D H

694 H D H D D D D D D H

695 H D D D D H H H D H

696 H D D D H D H H D H

697 H D D D H H D H D H

698 H D D D H H H D D H

699 H D D D D D H H D H

700 H D D D D H D H D H

701 H D D D D H H D D H

702 H D D D H D D H D H

703 H D D D H D H D D H

704 H D D D H H D D D H

705 H D D D D D D H D H

706 H D D D D D H D D H

707 H D D D D H D D D H

708 H D D D H D D D D H

709 H D D D D D D D D H

710 D D D H D H H H D H

71 1 D D D H H D H H D H

712 D D D H H H D H D H

713 D D D H H H H D D H

714 D D D H D D H H D H

715 D D D H D H D H D H

716 D D D H D H H D D H

717 D D D H H D D H D H

718 D D D H H D H D D H

719 D D D H H H D D D H

720 D D D H D D D H D H

721 D D D H D D H D D H

722 D D D H D H D D D H

723 D D D H H D D D D H

724 D D D H D D D D D H No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

725 D D H D D H H H D H

726 D D H D H D H H D H

727 D D H D H H D H D H

728 D D H D H H H D D H

729 D D H D D D H H D H

730 D D H D D H D H D H

731 D D H D D H H D D H

732 D D H D H D D H D H

733 D D H D H D H D D H

734 D D H D H H D D D H

735 D D H D D D D H D H

736 D D H D D D H D D H

737 D D H D D H D D D H

738 D D H D H D D D D H

739 D D H D D D D D D H

740 D D D D D H H H D H

741 D D D D H D H H D H

742 D D D D H H D H D H

743 D D D D H H H D D H

744 D D D D D D H H D H

745 D D D D D H D H D H

746 D D D D D H H D D H

747 D D D D H D D H D H

748 D D D D H D H D D H

749 D D D D H H D D D H

750 D D D D D D D H D H

751 D D D D D D H D D H

752 D D D D D H D D D H

753 D D D D H D D D D H

754 D D D D D D D D D H

755 D H D H D H H H H D

756 D H D H H D H H H D

757 D H D H H H D H H D

758 D H D H H H H D H D

759 D H D H D D H H H D

760 D H D H D H D H H D

761 D H D H D H H D H D

762 D H D H H D D H H D

763 D H D H H D H D H D

764 D H D H H H D D H D

765 D H D H D D D H H D

766 D H D H D D H D H D

767 D H D H D H D D H D

768 D H D H H D D D H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

769 D H D H D D D D H D

770 D H H D D H H H H D

771 D H H D H D H H H D

772 D H H D H H D H H D

773 D H H D H H H D H D

774 D H H D D D H H H D

775 D H H D D H D H H D

776 D H H D D H H D H D

111 D H H D H D D H H D

11% D H H D H D H D H D

119 D H H D H H D D H D

780 D H H D D D D H H D

781 D H H D D D H D H D

782 D H H D D H D D H D

783 D H H D H D D D H D

784 D H H D D D D D H D

785 D H D D D H H H H D

786 D H D D H D H H H D

787 D H D D H H D H H D

788 D H D D H H H D H D

789 D H D D D D H H H D

790 D H D D D H D H H D

791 D H D D D H H D H D

792 D H D D H D D H H D

793 D H D D H D H D H D

794 D H D D H H D D H D

795 D H D D D D D H H D

796 D H D D D D H D H D

797 D H D D D H D D H D

798 D H D D H D D D H D

799 D H D D D D D D H D

800 H D D H D H H H H D

801 H D D H H D H H H D

802 H D D H H H D H H D

803 H D D H H H H D H D

804 H D D H D D H H H D

805 H D D H D H D H H D

806 H D D H D H H D H D

807 H D D H H D D H H D

808 H D D H H D H D H D

809 H D D H H H D D H D

810 H D D H D D D H H D

81 1 H D D H D D H D H D

812 H D D H D H D D H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

813 H D D H H D D D H D

814 H D D H D D D D H D

815 H D H D D H H H H D

816 H D H D H D H H H D

817 H D H D H H D H H D

818 H D H D H H H D H D

819 H D H D D D H H H D

820 H D H D D H D H H D

821 H D H D D H H D H D

822 H D H D H D D H H D

823 H D H D H D H D H D

824 H D H D H H D D H D

825 H D H D D D D H H D

826 H D H D D D H D H D

827 H D H D D H D D H D

828 H D H D H D D D H D

829 H D H D D D D D H D

830 H D D D D H H H H D

831 H D D D H D H H H D

832 H D D D H H D H H D

833 H D D D H H H D H D

834 H D D D D D H H H D

835 H D D D D H D H H D

836 H D D D D H H D H D

837 H D D D H D D H H D

838 H D D D H D H D H D

839 H D D D H H D D H D

840 H D D D D D D H H D

841 H D D D D D H D H D

842 H D D D D H D D H D

843 H D D D H D D D H D

844 H D D D D D D D H D

845 D D D H D H H H H D

846 D D D H H D H H H D

847 D D D H H H D H H D

848 D D D H H H H D H D

849 D D D H D D H H H D

850 D D D H D H D H H D

851 D D D H D H H D H D

852 D D D H H D D H H D

853 D D D H H D H D H D

854 D D D H H H D D H D

855 D D D H D D D H H D

856 D D D H D D H D H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

857 D D D H D H D D H D

858 D D D H H D D D H D

859 D D D H D D D D H D

860 D D H D D H H H H D

861 D D H D H D H H H D

862 D D H D H H D H H D

863 D D H D H H H D H D

864 D D H D D D H H H D

865 D D H D D H D H H D

866 D D H D D H H D H D

867 D D H D H D D H H D

868 D D H D H D H D H D

869 D D H D H H D D H D

870 D D H D D D D H H D

871 D D H D D D H D H D

872 D D H D D H D D H D

873 D D H D H D D D H D

874 D D H D D D D D H D

875 D D D D D H H H H D

876 D D D D H D H H H D

877 D D D D H H D H H D

878 D D D D H H H D H D

879 D D D D D D H H H D

880 D D D D D H D H H D

881 D D D D D H H D H D

882 D D D D H D D H H D

883 D D D D H D H D H D

884 D D D D H H D D H D

885 D D D D D D D H H D

886 D D D D D D H D H D

887 D D D D D H D D H D

888 D D D D H D D D H D

889 D D D D D D D D H D

890 D H D H D H H H D D

891 D H D H H D H H D D

892 D H D H H H D H D D

893 D H D H H H H D D D

894 D H D H D D H H D D

895 D H D H D H D H D D

896 D H D H D H H D D D

897 D H D H H D D H D D

898 D H D H H D H D D D

899 D H D H H H D D D D

900 D H D H D D D H D D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

901 D H D H D D H D D D

902 D H D H D H D D D D

903 D H D H H D D D D D

904 D H D H D D D D D D

905 D H H D D H H H D D

906 D H H D H D H H D D

907 D H H D H H D H D D

908 D H H D H H H D D D

909 D H H D D D H H D D

910 D H H D D H D H D D

91 1 D H H D D H H D D D

912 D H H D H D D H D D

913 D H H D H D H D D D

914 D H H D H H D D D D

915 D H H D D D D H D D

916 D H H D D D H D D D

917 D H H D D H D D D D

918 D H H D H D D D D D

919 D H H D D D D D D D

920 D H D D D H H H D D

921 D H D D H D H H D D

922 D H D D H H D H D D

923 D H D D H H H D D D

924 D H D D D D H H D D

925 D H D D D H D H D D

926 D H D D D H H D D D

927 D H D D H D D H D D

928 D H D D H D H D D D

929 D H D D H H D D D D

930 D H D D D D D H D D

931 D H D D D D H D D D

932 D H D D D H D D D D

933 D H D D H D D D D D

934 D H D D D D D D D D

935 H D D H D H H H D D

936 H D D H H D H H D D

937 H D D H H H D H D D

938 H D D H H H H D D D

939 H D D H D D H H D D

940 H D D H D H D H D D

941 H D D H D H H D D D

942 H D D H H D D H D D

943 H D D H H D H D D D

944 H D D H H H D D D D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

945 H D D H D D D H D D

946 H D D H D D H D D D

947 H D D H D H D D D D

948 H D D H H D D D D D

949 H D D H D D D D D D

950 H D H D D H H H D D

951 H D H D H D H H D D

952 H D H D H H D H D D

953 H D H D H H H D D D

954 H D H D D D H H D D

955 H D H D D H D H D D

956 H D H D D H H D D D

957 H D H D H D D H D D

958 H D H D H D H D D D

959 H D H D H H D D D D

960 H D H D D D D H D D

961 H D H D D D H D D D

962 H D H D D H D D D D

963 H D H D H D D D D D

964 H D H D D D D D D D

965 H D D D D H H H D D

966 H D D D H D H H D D

967 H D D D H H D H D D

968 H D D D H H H D D D

969 H D D D D D H H D D

970 H D D D D H D H D D

971 H D D D D H H D D D

972 H D D D H D D H D D

973 H D D D H D H D D D

974 H D D D H H D D D D

975 H D D D D D D H D D

976 H D D D D D H D D D

977 H D D D D H D D D D

978 H D D D H D D D D D

979 H D D D D D D D D D

980 D D D H D H H H D D

981 D D D H H D H H D D

982 D D D H H H D H D D

983 D D D H H H H D D D

984 D D D H D D H H D D

985 D D D H D H D H D D

986 D D D H D H H D D D

987 D D D H H D D H D D

988 D D D H H D H D D D

Table 6. Compounds of Formulae Ill-a, Ill-b, III-c, and ΙΠ-d wherein each of R⁶ and R⁶ is hydrogen and each of 7 7'

R and R is deuterium.

1247 D H D D D H D H H H

1248 D H D D D H H D H H

1249 D H D D H D D H H H

1250 D H D D H D H D H H

1251 D H D D H H D D H H

1252 D H D D D D D H H H

1253 D H D D D D H D H H

1254 D H D D D H D D H H

1255 D H D D H D D D H H

1256 D H D D D D D D H H

1257 H D D H D H H H H H

1258 H D D H H D H H H H

1259 H D D H H H D H H H

1260 H D D H H H H D H H

1261 H D D H D D H H H H

1262 H D D H D H D H H H

1263 H D D H D H H D H H

1264 H D D H H D D H H H

1265 H D D H H D H D H H

1266 H D D H H H D D H H

1267 H D D H D D D H H H

1268 H D D H D D H D H H

1269 H D D H D H D D H H

1270 H D D H H D D D H H

1271 H D D H D D D D H H

1272 H D H D D H H H H H

1273 H D H D H D H H H H

1274 H D H D H H D H H H

1275 H D H D H H H D H H

1276 H D H D D D H H H H

1277 H D H D D H D H H H

1278 H D H D D H H D H H

1279 H D H D H D D H H H

1280 H D H D H D H D H H

1281 H D H D H H D D H H

1282 H D H D D D D H H H

1283 H D H D D D H D H H

1284 H D H D D H D D H H

1285 H D H D H D D D H H

1286 H D H D D D D D H H

1287 H D D D D H H H H H

1288 H D D D H D H H H H

1289 H D D D H H D H H H

1290 H D D D H H H D H H

1687 D H D D H D D D D H

1688 D H D D D D D D D H

1689 H D D H D H H H D H

1690 H D D H H D H H D H

1691 H D D H H H D H D H

1692 H D D H H H H D D H

1693 H D D H D D H H D H

1694 H D D H D H D H D H

1695 H D D H D H H D D H

1696 H D D H H D D H D H

1697 H D D H H D H D D H

1698 H D D H H H D D D H

1699 H D D H D D D H D H

1700 H D D H D D H D D H

1701 H D D H D H D D D H

1702 H D D H H D D D D H

1703 H D D H D D D D D H

1704 H D H D D H H H D H

1705 H D H D H D H H D H

1706 H D H D H H D H D H

1707 H D H D H H H D D H

1708 H D H D D D H H D H

1709 H D H D D H D H D H

1710 H D H D D H H D D H

1711 H D H D H D D H D H

1712 H D H D H D H D D H

1713 H D H D H H D D D H

1714 H D H D D D D H D H

1715 H D H D D D H D D H

1716 H D H D D H D D D H

1717 H D H D H D D D D H

1718 H D H D D D D D D H

1719 H D D D D H H H D H

1720 H D D D H D H H D H

1721 H D D D H H D H D H

1722 H D D D H H H D D H

1723 H D D D D D H H D H

1724 H D D D D H D H D H

1725 H D D D D H H D D H

1726 H D D D H D D H D H

1727 H D D D H D H D D H

1728 H D D D H H D D D H

1729 H D D D D D D H D H

1730 H D D D D D H D D H

Table 7. Compounds of Formulae Ill-a, Ill-b, III-c, and ΙΠ-d wherein each of R⁶ and R⁶ is deuterium and each of 7 7'

R and R is hydrogen.

No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2077 H D D H H H H H H H

2078 H D H D H H H H H H

2079 H D D D H H H H H H

2080 D D D H H H H H H H

2081 D D H D H H H H H H

2082 D D D D H H H H H H

2083 D H H H D H H H H H

2084 D H H H H D H H H H

2085 D H H H H H D H H H

2086 D H H H H H H D H H

2087 D H H H D D H H H H

2088 D H H H D H D H H H

2089 D H H H D H H D H H

2090 D H H H H D D H H H

2091 D H H H H D H D H H

2092 D H H H H H D D H H

2093 D H H H D D D H H H

2094 D H H H D D H D H H

2095 D H H H D H D D H H

2096 D H H H H D D D H H

2097 D H H H D D D D H H

2098 H D H H D H H H H H

2099 H D H H H D H H H H

2100 H D H H H H D H H H

2101 H D H H H H H D H H

2102 H D H H D D H H H H

2103 H D H H D H D H H H

2104 H D H H D H H D H H

2105 H D H H H D D H H H

2106 H D H H H D H D H H

2107 H D H H H H D D H H

2108 H D H H D D D H H H

2109 H D H H D D H D H H

2110 H D H H D H D D H H

2111 H D H H H D D D H H

2112 H D H H D D D D H H

2113 D D H H D H H H H H

2114 D D H H H D H H H H

2115 D D H H H H D H H H

2116 D D H H H H H D H H

2117 D D H H D D H H H H

2118 D D H H D H D H H H

2119 D D H H D H H D H H

2120 D D H H H D D H H H No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2121 D D H H H D H D H H

2122 D D H H H H D D H H

2123 D D H H D D D H H H

2124 D D H H D D H D H H

2125 D D H H D H D D H H

2126 D D H H H D D D H H

2127 D D H H D D D D H H

2128 D H H H H H H H D H

2129 D H H H H H H H H D

2130 D H H H H H H H D D

2131 H D H H H H H H D H

2132 H D H H H H H H H D

2133 H D H H H H H H D D

2134 D D H H H H H H D H

2135 D D H H H H H H H D

2136 D D H H H H H H D D

2137 H H D H D H H H H H

2138 H H D H H D H H H H

2139 H H D H H H D H H H

2140 H H D H H H H D H H

2141 H H D H D D H H H H

2142 H H D H D H D H H H

2143 H H D H D H H D H H

2144 H H D H H D D H H H

2145 H H D H H D H D H H

2146 H H D H H H D D H H

2147 H H D H D D D H H H

2148 H H D H D D H D H H

2149 H H D H D H D D H H

2150 H H D H H D D D H H

2151 H H D H D D D D H H

2152 H H H D D H H H H H

2153 H H H D H D H H H H

2154 H H H D H H D H H H

2155 H H H D H H H D H H

2156 H H H D D D H H H H

2157 H H H D D H D H H H

2158 H H H D D H H D H H

2159 H H H D H D D H H H

2160 H H H D H D H D H H

2161 H H H D H H D D H H

2162 H H H D D D D H H H

2163 H H H D D D H D H H

2164 H H H D D H D D H H No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2165 H H H D H D D D H H

2166 H H H D D D D D H H

2167 H H D D D H H H H H

2168 H H D D H D H H H H

2169 H H D D H H D H H H

2170 H H D D H H H D H H

2171 H H D D D D H H H H

2172 H H D D D H D H H H

2173 H H D D D H H D H H

2174 H H D D H D D H H H

2175 H H D D H D H D H H

2176 H H D D H H D D H H

2177 H H D D D D D H H H

2178 H H D D D D H D H H

2179 H H D D D H D D H H

2180 H H D D H D D D H H

2181 H H D D D D D D H H

2182 H H D H H H H H D H

2183 H H D H H H H H H D

2184 H H D H H H H H D D

2185 H H H D H H H H D H

2186 H H H D H H H H H D

2187 H H H D H H H H D D

2188 H H D D H H H H D H

2189 H H D D H H H H H D

2190 H H D D H H H H D D

2191 H H H H D H H H D H

2192 H H H H H D H H D H

2193 H H H H H H D H D H

2194 H H H H H H H D D H

2195 H H H H D D H H D H

2196 H H H H D H D H D H

2197 H H H H D H H D D H

2198 H H H H H D D H D H

2199 H H H H H D H D D H

2200 H H H H H H D D D H

2201 H H H H D D D H D H

2202 H H H H D D H D D H

2203 H H H H D H D D D H

2204 H H H H H D D D D H

2205 H H H H D D D D D H

2206 H H H H D H H H H D

2207 H H H H H D H H H D

2208 H H H H H H D H H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2209 H H H H H H H D H D

2210 H H H H D D H H H D

2211 H H H H D H D H H D

2212 H H H H D H H D H D

2213 H H H H H D D H H D

2214 H H H H H D H D H D

2215 H H H H H H D D H D

2216 H H H H D D D H H D

2217 H H H H D D H D H D

2218 H H H H D H D D H D

2219 H H H H H D D D H D

2220 H H H H D D D D H D

2221 H H H H D H H H D D

2222 H H H H H D H H D D

2223 H H H H H H D H D D

2224 H H H H H H H D D D

2225 H H H H D D H H D D

2226 H H H H D H D H D D

2227 H H H H D H H D D D

2228 H H H H H D D H D D

2229 H H H H H D H D D D

2230 H H H H H H D D D D

2231 H H H H D D D H D D

2232 H H H H D D H D D D

2233 H H H H D H D D D D

2234 H H H H H D D D D D

2235 H H H H D D D D D D

2236 D H D H D H H H H H

2237 D H D H H D H H H H

2238 D H D H H H D H H H

2239 D H D H H H H D H H

2240 D H D H D D H H H H

2241 D H D H D H D H H H

2242 D H D H D H H D H H

2243 D H D H H D D H H H

2244 D H D H H D H D H H

2245 D H D H H H D D H H

2246 D H D H D D D H H H

2247 D H D H D D H D H H

2248 D H D H D H D D H H

2249 D H D H H D D D H H

2250 D H D H D D D D H H

2251 D H H D D H H H H H

2252 D H H D H D H H H H No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2253 D H H D H H D H H H

2254 D H H D H H H D H H

2255 D H H D D D H H H H

2256 D H H D D H D H H H

2257 D H H D D H H D H H

2258 D H H D H D D H H H

2259 D H H D H D H D H H

2260 D H H D H H D D H H

2261 D H H D D D D H H H

2262 D H H D D D H D H H

2263 D H H D D H D D H H

2264 D H H D H D D D H H

2265 D H H D D D D D H H

2266 D H D D D H H H H H

2267 D H D D H D H H H H

2268 D H D D H H D H H H

2269 D H D D H H H D H H

2270 D H D D D D H H H H

2271 D H D D D H D H H H

2272 D H D D D H H D H H

2273 D H D D H D D H H H

2274 D H D D H D H D H H

2275 D H D D H H D D H H

2276 D H D D D D D H H H

2277 D H D D D D H D H H

2278 D H D D D H D D H H

2279 D H D D H D D D H H

2280 D H D D D D D D H H

2281 H D D H D H H H H H

2282 H D D H H D H H H H

2283 H D D H H H D H H H

2284 H D D H H H H D H H

2285 H D D H D D H H H H

2286 H D D H D H D H H H

2287 H D D H D H H D H H

2288 H D D H H D D H H H

2289 H D D H H D H D H H

2290 H D D H H H D D H H

2291 H D D H D D D H H H

2292 H D D H D D H D H H

2293 H D D H D H D D H H

2294 H D D H H D D D H H

2295 H D D H D D D D H H

2296 H D H D D H H H H H No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2297 H D H D H D H H H H

2298 H D H D H H D H H H

2299 H D H D H H H D H H

2300 H D H D D D H H H H

2301 H D H D D H D H H H

2302 H D H D D H H D H H

2303 H D H D H D D H H H

2304 H D H D H D H D H H

2305 H D H D H H D D H H

2306 H D H D D D D H H H

2307 H D H D D D H D H H

2308 H D H D D H D D H H

2309 H D H D H D D D H H

2310 H D H D D D D D H H

2311 H D D D D H H H H H

2312 H D D D H D H H H H

2313 H D D D H H D H H H

2314 H D D D H H H D H H

2315 H D D D D D H H H H

2316 H D D D D H D H H H

2317 H D D D D H H D H H

2318 H D D D H D D H H H

2319 H D D D H D H D H H

2320 H D D D H H D D H H

2321 H D D D D D D H H H

2322 H D D D D D H D H H

2323 H D D D D H D D H H

2324 H D D D H D D D H H

2325 H D D D D D D D H H

2326 D D D H D H H H H H

2327 D D D H H D H H H H

2328 D D D H H H D H H H

2329 D D D H H H H D H H

2330 D D D H D D H H H H

2331 D D D H D H D H H H

2332 D D D H D H H D H H

2333 D D D H H D D H H H

2334 D D D H H D H D H H

2335 D D D H H H D D H H

2336 D D D H D D D H H H

2337 D D D H D D H D H H

2338 D D D H D H D D H H

2339 D D D H H D D D H H

2340 D D D H D D D D H H No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2341 D D H D D H H H H H

2342 D D H D H D H H H H

2343 D D H D H H D H H H

2344 D D H D H H H D H H

2345 D D H D D D H H H H

2346 D D H D D H D H H H

2347 D D H D D H H D H H

2348 D D H D H D D H H H

2349 D D H D H D H D H H

2350 D D H D H H D D H H

2351 D D H D D D D H H H

2352 D D H D D D H D H H

2353 D D H D D H D D H H

2354 D D H D H D D D H H

2355 D D H D D D D D H H

2356 D D D D D H H H H H

2357 D D D D H D H H H H

2358 D D D D H H D H H H

2359 D D D D H H H D H H

2360 D D D D D D H H H H

2361 D D D D D H D H H H

2362 D D D D D H H D H H

2363 D D D D H D D H H H

2364 D D D D H D H D H H

2365 D D D D H H D D H H

2366 D D D D D D D H H H

2367 D D D D D D H D H H

2368 D D D D D H D D H H

2369 D D D D H D D D H H

2370 D D D D D D D D H H

2371 D H D H H H H H D H

2372 D H H D H H H H D H

2373 D H D D H H H H D H

2374 H D D H H H H H D H

2375 H D H D H H H H D H

2376 H D D D H H H H D H

2377 D D D H H H H H D H

2378 D D H D H H H H D H

2379 D D D D H H H H D H

2380 D H D H H H H H H D

2381 D H H D H H H H H D

2382 D H D D H H H H H D

2383 H D D H H H H H H D

2384 H D H D H H H H H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2385 H D D D H H H H H D

2386 D D D H H H H H H D

2387 D D H D H H H H H D

2388 D D D D H H H H H D

2389 D H D H H H H H D D

2390 D H H D H H H H D D

2391 D H D D H H H H D D

2392 H D D H H H H H D D

2393 H D H D H H H H D D

2394 H D D D H H H H D D

2395 D D D H H H H H D D

2396 D D H D H H H H D D

2397 D D D D H H H H D D

2398 D H H H D H H H D H

2399 D H H H H D H H D H

2400 D H H H H H D H D H

2401 D H H H H H H D D H

2402 D H H H D D H H D H

2403 D H H H D H D H D H

2404 D H H H D H H D D H

2405 D H H H H D D H D H

2406 D H H H H D H D D H

2407 D H H H H H D D D H

2408 D H H H D D D H D H

2409 D H H H D D H D D H

2410 D H H H D H D D D H

2411 D H H H H D D D D H

2412 D H H H D D D D D H

2413 D H H H D H H H H D

2414 D H H H H D H H H D

2415 D H H H H H D H H D

2416 D H H H H H H D H D

2417 D H H H D D H H H D

2418 D H H H D H D H H D

2419 D H H H D H H D H D

2420 D H H H H D D H H D

2421 D H H H H D H D H D

2422 D H H H H H D D H D

2423 D H H H D D D H H D

2424 D H H H D D H D H D

2425 D H H H D H D D H D

2426 D H H H H D D D H D

2427 D H H H D D D D H D

2428 D H H H D H H H D D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2429 D H H H H D H H D D

2430 D H H H H H D H D D

2431 D H H H H H H D D D

2432 D H H H D D H H D D

2433 D H H H D H D H D D

2434 D H H H D H H D D D

2435 D H H H H D D H D D

2436 D H H H H D H D D D

2437 D H H H H H D D D D

2438 D H H H D D D H D D

2439 D H H H D D H D D D

2440 D H H H D H D D D D

2441 D H H H H D D D D D

2442 D H H H D D D D D D

2443 H D H H D H H H D H

2444 H D H H H D H H D H

2445 H D H H H H D H D H

2446 H D H H H H H D D H

2447 H D H H D D H H D H

2448 H D H H D H D H D H

2449 H D H H D H H D D H

2450 H D H H H D D H D H

2451 H D H H H D H D D H

2452 H D H H H H D D D H

2453 H D H H D D D H D H

2454 H D H H D D H D D H

2455 H D H H D H D D D H

2456 H D H H H D D D D H

2457 H D H H D D D D D H

2458 H D H H D H H H H D

2459 H D H H H D H H H D

2460 H D H H H H D H H D

2461 H D H H H H H D H D

2462 H D H H D D H H H D

2463 H D H H D H D H H D

2464 H D H H D H H D H D

2465 H D H H H D D H H D

2466 H D H H H D H D H D

2467 H D H H H H D D H D

2468 H D H H D D D H H D

2469 H D H H D D H D H D

2470 H D H H D H D D H D

2471 H D H H H D D D H D

2472 H D H H D D D D H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2473 H D H H D H H H D D

2474 H D H H H D H H D D

2475 H D H H H H D H D D

2476 H D H H H H H D D D

2477 H D H H D D H H D D

2478 H D H H D H D H D D

2479 H D H H D H H D D D

2480 H D H H H D D H D D

2481 H D H H H D H D D D

2482 H D H H H H D D D D

2483 H D H H D D D H D D

2484 H D H H D D H D D D

2485 H D H H D H D D D D

2486 H D H H H D D D D D

2487 H D H H D D D D D D

2488 D D H H D H H H D H

2489 D D H H H D H H D H

2490 D D H H H H D H D H

2491 D D H H H H H D D H

2492 D D H H D D H H D H

2493 D D H H D H D H D H

2494 D D H H D H H D D H

2495 D D H H H D D H D H

2496 D D H H H D H D D H

2497 D D H H H H D D D H

2498 D D H H D D D H D H

2499 D D H H D D H D D H

2500 D D H H D H D D D H

2501 D D H H H D D D D H

2502 D D H H D D D D D H

2503 D D H H D H H H H D

2504 D D H H H D H H H D

2505 D D H H H H D H H D

2506 D D H H H H H D H D

2507 D D H H D D H H H D

2508 D D H H D H D H H D

2509 D D H H D H H D H D

2510 D D H H H D D H H D

2511 D D H H H D H D H D

2512 D D H H H H D D H D

2513 D D H H D D D H H D

2514 D D H H D D H D H D

2515 D D H H D H D D H D

2516 D D H H H D D D H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2517 D D H H D D D D H D

2518 D D H H D H H H D D

2519 D D H H H D H H D D

2520 D D H H H H D H D D

2521 D D H H H H H D D D

2522 D D H H D D H H D D

2523 D D H H D H D H D D

2524 D D H H D H H D D D

2525 D D H H H D D H D D

2526 D D H H H D H D D D

2527 D D H H H H D D D D

2528 D D H H D D D H D D

2529 D D H H D D H D D D

2530 D D H H D H D D D D

2531 D D H H H D D D D D

2532 D D H H D D D D D D

2533 H H D H D H H H D H

2534 H H D H H D H H D H

2535 H H D H H H D H D H

2536 H H D H H H H D D H

2537 H H D H D D H H D H

2538 H H D H D H D H D H

2539 H H D H D H H D D H

2540 H H D H H D D H D H

2541 H H D H H D H D D H

2542 H H D H H H D D D H

2543 H H D H D D D H D H

2544 H H D H D D H D D H

2545 H H D H D H D D D H

2546 H H D H H D D D D H

2547 H H D H D D D D D H

2548 H H D H D H H H H D

2549 H H D H H D H H H D

2550 H H D H H H D H H D

2551 H H D H H H H D H D

2552 H H D H D D H H H D

2553 H H D H D H D H H D

2554 H H D H D H H D H D

2555 H H D H H D D H H D

2556 H H D H H D H D H D

2557 H H D H H H D D H D

2558 H H D H D D D H H D

2559 H H D H D D H D H D

2560 H H D H D H D D H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2561 H H D H H D D D H D

2562 H H D H D D D D H D

2563 H H D H D H H H D D

2564 H H D H H D H H D D

2565 H H D H H H D H D D

2566 H H D H H H H D D D

2567 H H D H D D H H D D

2568 H H D H D H D H D D

2569 H H D H D H H D D D

2570 H H D H H D D H D D

2571 H H D H H D H D D D

2572 H H D H H H D D D D

2573 H H D H D D D H D D

2574 H H D H D D H D D D

2575 H H D H D H D D D D

2576 H H D H H D D D D D

2577 H H D H D D D D D D

2578 H H H D D H H H D H

2579 H H H D H D H H D H

2580 H H H D H H D H D H

2581 H H H D H H H D D H

2582 H H H D D D H H D H

2583 H H H D D H D H D H

2584 H H H D D H H D D H

2585 H H H D H D D H D H

2586 H H H D H D H D D H

2587 H H H D H H D D D H

2588 H H H D D D D H D H

2589 H H H D D D H D D H

2590 H H H D D H D D D H

2591 H H H D H D D D D H

2592 H H H D D D D D D H

2593 H H H D D H H H H D

2594 H H H D H D H H H D

2595 H H H D H H D H H D

2596 H H H D H H H D H D

2597 H H H D D D H H H D

2598 H H H D D H D H H D

2599 H H H D D H H D H D

2600 H H H D H D D H H D

2601 H H H D H D H D H D

2602 H H H D H H D D H D

2603 H H H D D D D H H D

2604 H H H D D D H D H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2605 H H H D D H D D H D

2606 H H H D H D D D H D

2607 H H H D D D D D H D

2608 H H H D D H H H D D

2609 H H H D H D H H D D

2610 H H H D H H D H D D

261 1 H H H D H H H D D D

2612 H H H D D D H H D D

2613 H H H D D H D H D D

2614 H H H D D H H D D D

2615 H H H D H D D H D D

2616 H H H D H D H D D D

2617 H H H D H H D D D D

2618 H H H D D D D H D D

2619 H H H D D D H D D D

2620 H H H D D H D D D D

2621 H H H D H D D D D D

2622 H H H D D D D D D D

2623 H H D D D H H H D H

2624 H H D D H D H H D H

2625 H H D D H H D H D H

2626 H H D D H H H D D H

2627 H H D D D D H H D H

2628 H H D D D H D H D H

2629 H H D D D H H D D H

2630 H H D D H D D H D H

2631 H H D D H D H D D H

2632 H H D D H H D D D H

2633 H H D D D D D H D H

2634 H H D D D D H D D H

2635 H H D D D H D D D H

2636 H H D D H D D D D H

2637 H H D D D D D D D H

2638 H H D D D H H H H D

2639 H H D D H D H H H D

2640 H H D D H H D H H D

2641 H H D D H H H D H D

2642 H H D D D D H H H D

2643 H H D D D H D H H D

2644 H H D D D H H D H D

2645 H H D D H D D H H D

2646 H H D D H D H D H D

2647 H H D D H H D D H D

2648 H H D D D D D H H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2649 H H D D D D H D H D

2650 H H D D D H D D H D

2651 H H D D H D D D H D

2652 H H D D D D D D H D

2653 H H D D D H H H D D

2654 H H D D H D H H D D

2655 H H D D H H D H D D

2656 H H D D H H H D D D

2657 H H D D D D H H D D

2658 H H D D D H D H D D

2659 H H D D D H H D D D

2660 H H D D H D D H D D

2661 H H D D H D H D D D

2662 H H D D H H D D D D

2663 H H D D D D D H D D

2664 H H D D D D H D D D

2665 H H D D D H D D D D

2666 H H D D H D D D D D

2667 H H D D D D D D D D

2668 D H D H D H H H D H

2669 D H D H H D H H D H

2670 D H D H H H D H D H

2671 D H D H H H H D D H

2672 D H D H D D H H D H

2673 D H D H D H D H D H

2674 D H D H D H H D D H

2675 D H D H H D D H D H

2676 D H D H H D H D D H

2677 D H D H H H D D D H

2678 D H D H D D D H D H

2679 D H D H D D H D D H

2680 D H D H D H D D D H

2681 D H D H H D D D D H

2682 D H D H D D D D D H

2683 D H H D D H H H D H

2684 D H H D H D H H D H

2685 D H H D H H D H D H

2686 D H H D H H H D D H

2687 D H H D D D H H D H

2688 D H H D D H D H D H

2689 D H H D D H H D D H

2690 D H H D H D D H D H

2691 D H H D H D H D D H

2692 D H H D H H D D D H No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2693 D H H D D D D H D H

2694 D H H D D D H D D H

2695 D H H D D H D D D H

2696 D H H D H D D D D H

2697 D H H D D D D D D H

2698 D H D D D H H H D H

2699 D H D D H D H H D H

2700 D H D D H H D H D H

2701 D H D D H H H D D H

2702 D H D D D D H H D H

2703 D H D D D H D H D H

2704 D H D D D H H D D H

2705 D H D D H D D H D H

2706 D H D D H D H D D H

2707 D H D D H H D D D H

2708 D H D D D D D H D H

2709 D H D D D D H D D H

2710 D H D D D H D D D H

2711 D H D D H D D D D H

2712 D H D D D D D D D H

2713 H D D H D H H H D H

2714 H D D H H D H H D H

2715 H D D H H H D H D H

2716 H D D H H H H D D H

2717 H D D H D D H H D H

2718 H D D H D H D H D H

2719 H D D H D H H D D H

2720 H D D H H D D H D H

2721 H D D H H D H D D H

2722 H D D H H H D D D H

2723 H D D H D D D H D H

2724 H D D H D D H D D H

2725 H D D H D H D D D H

2726 H D D H H D D D D H

2727 H D D H D D D D D H

2728 H D H D D H H H D H

2729 H D H D H D H H D H

2730 H D H D H H D H D H

2731 H D H D H H H D D H

2732 H D H D D D H H D H

2733 H D H D D H D H D H

2734 H D H D D H H D D H

2735 H D H D H D D H D H

2736 H D H D H D H D D H No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2737 H D H D H H D D D H

2738 H D H D D D D H D H

2739 H D H D D D H D D H

2740 H D H D D H D D D H

2741 H D H D H D D D D H

2742 H D H D D D D D D H

2743 H D D D D H H H D H

2744 H D D D H D H H D H

2745 H D D D H H D H D H

2746 H D D D H H H D D H

2747 H D D D D D H H D H

2748 H D D D D H D H D H

2749 H D D D D H H D D H

2750 H D D D H D D H D H

2751 H D D D H D H D D H

2752 H D D D H H D D D H

2753 H D D D D D D H D H

2754 H D D D D D H D D H

2755 H D D D D H D D D H

2756 H D D D H D D D D H

2757 H D D D D D D D D H

2758 D D D H D H H H D H

2759 D D D H H D H H D H

2760 D D D H H H D H D H

2761 D D D H H H H D D H

2762 D D D H D D H H D H

2763 D D D H D H D H D H

2764 D D D H D H H D D H

2765 D D D H H D D H D H

2766 D D D H H D H D D H

2767 D D D H H H D D D H

2768 D D D H D D D H D H

2769 D D D H D D H D D H

2770 D D D H D H D D D H

2771 D D D H H D D D D H

2772 D D D H D D D D D H

2773 D D H D D H H H D H

2774 D D H D H D H H D H

2775 D D H D H H D H D H

2776 D D H D H H H D D H

2777 D D H D D D H H D H

2778 D D H D D H D H D H

2779 D D H D D H H D D H

2780 D D H D H D D H D H No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2781 D D H D H D H D D H

2782 D D H D H H D D D H

2783 D D H D D D D H D H

2784 D D H D D D H D D H

2785 D D H D D H D D D H

2786 D D H D H D D D D H

2787 D D H D D D D D D H

2788 D D D D D H H H D H

2789 D D D D H D H H D H

2790 D D D D H H D H D H

2791 D D D D H H H D D H

2792 D D D D D D H H D H

2793 D D D D D H D H D H

2794 D D D D D H H D D H

2795 D D D D H D D H D H

2796 D D D D H D H D D H

2797 D D D D H H D D D H

2798 D D D D D D D H D H

2799 D D D D D D H D D H

2800 D D D D D H D D D H

2801 D D D D H D D D D H

2802 D D D D D D D D D H

2803 D H D H D H H H H D

2804 D H D H H D H H H D

2805 D H D H H H D H H D

2806 D H D H H H H D H D

2807 D H D H D D H H H D

2808 D H D H D H D H H D

2809 D H D H D H H D H D

2810 D H D H H D D H H D

2811 D H D H H D H D H D

2812 D H D H H H D D H D

2813 D H D H D D D H H D

2814 D H D H D D H D H D

2815 D H D H D H D D H D

2816 D H D H H D D D H D

2817 D H D H D D D D H D

2818 D H H D D H H H H D

2819 D H H D H D H H H D

2820 D H H D H H D H H D

2821 D H H D H H H D H D

2822 D H H D D D H H H D

2823 D H H D D H D H H D

2824 D H H D D H H D H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2825 D H H D H D D H H D

2826 D H H D H D H D H D

2827 D H H D H H D D H D

2828 D H H D D D D H H D

2829 D H H D D D H D H D

2830 D H H D D H D D H D

2831 D H H D H D D D H D

2832 D H H D D D D D H D

2833 D H D D D H H H H D

2834 D H D D H D H H H D

2835 D H D D H H D H H D

2836 D H D D H H H D H D

2837 D H D D D D H H H D

2838 D H D D D H D H H D

2839 D H D D D H H D H D

2840 D H D D H D D H H D

2841 D H D D H D H D H D

2842 D H D D H H D D H D

2843 D H D D D D D H H D

2844 D H D D D D H D H D

2845 D H D D D H D D H D

2846 D H D D H D D D H D

2847 D H D D D D D D H D

2848 H D D H D H H H H D

2849 H D D H H D H H H D

2850 H D D H H H D H H D

2851 H D D H H H H D H D

2852 H D D H D D H H H D

2853 H D D H D H D H H D

2854 H D D H D H H D H D

2855 H D D H H D D H H D

2856 H D D H H D H D H D

2857 H D D H H H D D H D

2858 H D D H D D D H H D

2859 H D D H D D H D H D

2860 H D D H D H D D H D

2861 H D D H H D D D H D

2862 H D D H D D D D H D

2863 H D H D D H H H H D

2864 H D H D H D H H H D

2865 H D H D H H D H H D

2866 H D H D H H H D H D

2867 H D H D D D H H H D

2868 H D H D D H D H H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R _Rxa _Rxb _Rxb^< _Rxc

9^l7R^9b' R^y7R^ya R^yl,/R⁵"'^'

2869 H D H D D H H D H D

2870 H D H D H D D H H D

2871 H D H D H D H D H D

2872 H D H D H H D D H D

2873 H D H D D D D H H D

2874 H D H D D D H D H D

2875 H D H D D H D D H D

2876 H D H D H D D D H D

2877 H D H D D D D D H D

2878 H D D D D H H H H D

2879 H D D D H D H H H D

2880 H D D D H H D H H D

2881 H D D D H H H D H D

2882 H D D D D D H H H D

2883 H D D D D H D H H D

2884 H D D D D H H D H D

2885 H D D D H D D H H D

2886 H D D D H D H D H D

2887 H D D D H H D D H D

2888 H D D D D D D H H D

2889 H D D D D D H D H D

2890 H D D D D H D D H D

2891 H D D D H D D D H D

2892 H D D D D D D D H D

2893 D D D H D H H H H D

2894 D D D H H D H H H D

2895 D D D H H H D H H D

2896 D D D H H H H D H D

2897 D D D H D D H H H D

2898 D D D H D H D H H D

2899 D D D H D H H D H D

2900 D D D H H D D H H D

2901 D D D H H D H D H D

2902 D D D H H H D D H D

2903 D D D H D D D H H D

2904 D D D H D D H D H D

2905 D D D H D H D D H D

2906 D D D H H D D D H D

2907 D D D H D D D D H D

2908 D D H D D H H H H D

2909 D D H D H D H H H D

2910 D D H D H H D H H D

2911 D D H D H H H D H D

2912 D D H D D D H H H D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2913 D D H D D H D H H D

2914 D D H D D H H D H D

2915 D D H D H D D H H D

2916 D D H D H D H D H D

2917 D D H D H H D D H D

2918 D D H D D D D H H D

2919 D D H D D D H D H D

2920 D D H D D H D D H D

2921 D D H D H D D D H D

2922 D D H D D D D D H D

2923 D D D D D H H H H D

2924 D D D D H D H H H D

2925 D D D D H H D H H D

2926 D D D D H H H D H D

2927 D D D D D D H H H D

2928 D D D D D H D H H D

2929 D D D D D H H D H D

2930 D D D D H D D H H D

2931 D D D D H D H D H D

2932 D D D D H H D D H D

2933 D D D D D D D H H D

2934 D D D D D D H D H D

2935 D D D D D H D D H D

2936 D D D D H D D D H D

2937 D D D D D D D D H D

2938 D H D H D H H H D D

2939 D H D H H D H H D D

2940 D H D H H H D H D D

2941 D H D H H H H D D D

2942 D H D H D D H H D D

2943 D H D H D H D H D D

2944 D H D H D H H D D D

2945 D H D H H D D H D D

2946 D H D H H D H D D D

2947 D H D H H H D D D D

2948 D H D H D D D H D D

2949 D H D H D D H D D D

2950 D H D H D H D D D D

2951 D H D H H D D D D D

2952 D H D H D D D D D D

2953 D H H D D H H H D D

2954 D H H D H D H H D D

2955 D H H D H H D H D D

2956 D H H D H H H D D D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

2957 D H H D D D H H D D

2958 D H H D D H D H D D

2959 D H H D D H H D D D

2960 D H H D H D D H D D

2961 D H H D H D H D D D

2962 D H H D H H D D D D

2963 D H H D D D D H D D

2964 D H H D D D H D D D

2965 D H H D D H D D D D

2966 D H H D H D D D D D

2967 D H H D D D D D D D

2968 D H D D D H H H D D

2969 D H D D H D H H D D

2970 D H D D H H D H D D

2971 D H D D H H H D D D

2972 D H D D D D H H D D

2973 D H D D D H D H D D

2974 D H D D D H H D D D

2975 D H D D H D D H D D

2976 D H D D H D H D D D

2977 D H D D H H D D D D

2978 D H D D D D D H D D

2979 D H D D D D H D D D

2980 D H D D D H D D D D

2981 D H D D H D D D D D

2982 D H D D D D D D D D

2983 H D D H D H H H D D

2984 H D D H H D H H D D

2985 H D D H H H D H D D

2986 H D D H H H H D D D

2987 H D D H D D H H D D

2988 H D D H D H D H D D

2989 H D D H D H H D D D

2990 H D D H H D D H D D

2991 H D D H H D H D D D

2992 H D D H H H D D D D

2993 H D D H D D D H D D

2994 H D D H D D H D D D

2995 H D D H D H D D D D

2996 H D D H H D D D D D

2997 H D D H D D D D D D

2998 H D H D D H H H D D

2999 H D H D H D H H D D

3000 H D H D H H D H D D No. R*7R*^a R^m/R^m' R^ya/R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc R^y7R^ya R^yl,/R⁵"'^'

3001 H D H D H H H D D D

3002 H D H D D D H H D D

3003 H D H D D H D H D D

3004 H D H D D H H D D D

3005 H D H D H D D H D D

3006 H D H D H D H D D D

3007 H D H D H H D D D D

3008 H D H D D D D H D D

3009 H D H D D D H D D D

3010 H D H D D H D D D D

3011 H D H D H D D D D D

3012 H D H D D D D D D D

3013 H D D D D H H H D D

3014 H D D D H D H H D D

3015 H D D D H H D H D D

3016 H D D D H H H D D D

3017 H D D D D D H H D D

3018 H D D D D H D H D D

3019 H D D D D H H D D D

3020 H D D D H D D H D D

3021 H D D D H D H D D D

3022 H D D D H H D D D D

3023 H D D D D D D H D D

3024 H D D D D D H D D D

3025 H D D D D H D D D D

3026 H D D D H D D D D D

3027 H D D D D D D D D D

3028 D D D H D H H H D D

3029 D D D H H D H H D D

3030 D D D H H H D H D D

3031 D D D H H H H D D D

3032 D D D H D D H H D D

3033 D D D H D H D H D D

3034 D D D H D H H D D D

3035 D D D H H D D H D D

3036 D D D H H D H D D D

3037 D D D H H H D D D D

3038 D D D H D D D H D D

3039 D D D H D D H D D D

3040 D D D H D H D D D D

3041 D D D H H D D D D D

3042 D D D H D D D D D D

3043 D D H D D H H H D D

3044 D D H D H D H H D D No. R^8a/R^8a R^m/R^m' R^9a/R^9a' R^9b/R^9b' _Rxa _Rxb _Rxb^< _Rxc R^ya/R^ya R^yl,/R^yb'

3045 D D H D H H D H D D

3046 D D H D H H H D D D

3047 D D H D D D H H D D

3048 D D H D D H D H D D

3049 D D H D D H H D D D

3050 D D H D H D D H D D

3051 D D H D H D H D D D

3052 D D H D H H D D D D

3053 D D H D D D D H D D

3054 D D H D D D H D D D

3055 D D H D D H D D D D

3056 D D H D H D D D D D

3057 D D H D D D D D D D

3058 D D D D D H H H D D

3059 D D D D H D H H D D

3060 D D D D H H D H D D

3061 D D D D H H H D D D

3062 D D D D D D H H D D

3063 D D D D D H D H D D

3064 D D D D D H H D D D

3065 D D D D H D D H D D

3066 D D D D H D H D D D

3067 D D D D H H D D D D

3068 D D D D D D D H D D

3069 D D D D D D H D D D

3070 D D D D D H D D D D

3071 D D D D H D D D D D

3072 D D D D D D D D D D

Table 8. Compounds of Formulae Ill-a, Ill-b, III-c, and Ill-d wherein each of R⁶, R⁶ , R⁷ and R⁷ is deuterium.

3083 H H H H H H H D H H

3084 H H H H D D H H H H

3085 H H H H D H D H H H

3086 H H H H D H H D H H

3087 H H H H H D D H H H

3088 H H H H H D H D H H

3089 H H H H H H D D H H

3090 H H H H D D D H H H

3091 H H H H D D H D H H

3092 H H H H D H D D H H

3093 H H H H H D D D H H

3094 H H H H D D D D H H

3095 H H H H H H H H D H

3096 H H H H H H H H H D

3097 H H H H H H H H D D

3098 D H D H H H H H H H

3099 D H H D H H H H H H

3100 D H D D H H H H H H

3101 H D D H H H H H H H

3102 H D H D H H H H H H

3103 H D D D H H H H H H

3104 D D D H H H H H H H

3105 D D H D H H H H H H

3106 D D D D H H H H H H

3107 D H H H D H H H H H

3108 D H H H H D H H H H

3109 D H H H H H D H H H

3110 D H H H H H H D H H

3111 D H H H D D H H H H

3112 D H H H D H D H H H

3113 D H H H D H H D H H

3114 D H H H H D D H H H

3115 D H H H H D H D H H

3116 D H H H H H D D H H

3117 D H H H D D D H H H

3118 D H H H D D H D H H

3119 D H H H D H D D H H

3120 D H H H H D D D H H

3121 D H H H D D D D H H

3122 H D H H D H H H H H

3123 H D H H H D H H H H

3124 H D H H H H D H H H

3125 H D H H H H H D H H

3126 H D H H D D H H H H

3259 H H H H D D D D D D

3260 D H D H D H H H H H

3261 D H D H H D H H H H

3262 D H D H H H D H H H

3263 D H D H H H H D H H

3264 D H D H D D H H H H

3265 D H D H D H D H H H

3266 D H D H D H H D H H

3267 D H D H H D D H H H

3268 D H D H H D H D H H

3269 D H D H H H D D H H

3270 D H D H D D D H H H

3271 D H D H D D H D H H

3272 D H D H D H D D H H

3273 D H D H H D D D H H

3274 D H D H D D D D H H

3275 D H H D D H H H H H

3276 D H H D H D H H H H

3277 D H H D H H D H H H

3278 D H H D H H H D H H

3279 D H H D D D H H H H

3280 D H H D D H D H H H

3281 D H H D D H H D H H

3282 D H H D H D D H H H

3283 D H H D H D H D H H

3284 D H H D H H D D H H

3285 D H H D D D D H H H

3286 D H H D D D H D H H

3287 D H H D D H D D H H

3288 D H H D H D D D H H

3289 D H H D D D D D H H

3290 D H D D D H H H H H

3291 D H D D H D H H H H

3292 D H D D H H D H H H

3293 D H D D H H H D H H

3294 D H D D D D H H H H

3295 D H D D D H D H H H

3296 D H D D D H H D H H

3297 D H D D H D D H H H

3298 D H D D H D H D H H

3299 D H D D H H D D H H

3300 D H D D D D D H H H

3301 D H D D D D H D H H

3302 D H D D D H D D H H No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

3303 D H D D H D D D H H

3304 D H D D D D D D H H

3305 H D D H D H H H H H

3306 H D D H H D H H H H

3307 H D D H H H D H H H

3308 H D D H H H H D H H

3309 H D D H D D H H H H

3310 H D D H D H D H H H

331 1 H D D H D H H D H H

3312 H D D H H D D H H H

3313 H D D H H D H D H H

3314 H D D H H H D D H H

3315 H D D H D D D H H H

3316 H D D H D D H D H H

3317 H D D H D H D D H H

3318 H D D H H D D D H H

3319 H D D H D D D D H H

3320 H D H D D H H H H H

3321 H D H D H D H H H H

3322 H D H D H H D H H H

3323 H D H D H H H D H H

3324 H D H D D D H H H H

3325 H D H D D H D H H H

3326 H D H D D H H D H H

3327 H D H D H D D H H H

3328 H D H D H D H D H H

3329 H D H D H H D D H H

3330 H D H D D D D H H H

3331 H D H D D D H D H H

3332 H D H D D H D D H H

3333 H D H D H D D D H H

3334 H D H D D D D D H H

3335 H D D D D H H H H H

3336 H D D D H D H H H H

3337 H D D D H H D H H H

3338 H D D D H H H D H H

3339 H D D D D D H H H H

3340 H D D D D H D H H H

3341 H D D D D H H D H H

3342 H D D D H D D H H H

3343 H D D D H D H D H H

3344 H D D D H H D D H H

3345 H D D D D D D H H H

3346 H D D D D D H D H H No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

3347 H D D D D H D D H H

3348 H D D D H D D D H H

3349 H D D D D D D D H H

3350 D D D H D H H H H H

3351 D D D H H D H H H H

3352 D D D H H H D H H H

3353 D D D H H H H D H H

3354 D D D H D D H H H H

3355 D D D H D H D H H H

3356 D D D H D H H D H H

3357 D D D H H D D H H H

3358 D D D H H D H D H H

3359 D D D H H H D D H H

3360 D D D H D D D H H H

3361 D D D H D D H D H H

3362 D D D H D H D D H H

3363 D D D H H D D D H H

3364 D D D H D D D D H H

3365 D D H D D H H H H H

3366 D D H D H D H H H H

3367 D D H D H H D H H H

3368 D D H D H H H D H H

3369 D D H D D D H H H H

3370 D D H D D H D H H H

3371 D D H D D H H D H H

3372 D D H D H D D H H H

3373 D D H D H D H D H H

3374 D D H D H H D D H H

3375 D D H D D D D H H H

3376 D D H D D D H D H H

3377 D D H D D H D D H H

3378 D D H D H D D D H H

3379 D D H D D D D D H H

3380 D D D D D H H H H H

3381 D D D D H D H H H H

3382 D D D D H H D H H H

3383 D D D D H H H D H H

3384 D D D D D D H H H H

3385 D D D D D H D H H H

3386 D D D D D H H D H H

3387 D D D D H D D H H H

3388 D D D D H D H D H H

3389 D D D D H H D D H H

3390 D D D D D D D H H H

3435 D H H H H D D D D H

3436 D H H H D D D D D H

3437 D H H H D H H H H D

3438 D H H H H D H H H D

3439 D H H H H H D H H D

3434 D H H H H H H D H D

3441 D H H H D D H H H D

3442 D H H H D H D H H D

3443 D H H H D H H D H D

3444 D H H H H D D H H D

3445 D H H H H D H D H D

3446 D H H H H H D D H D

3447 D H H H D D D H H D

3448 D H H H D D H D H D

3449 D H H H D H D D H D

3450 D H H H H D D D H D

3451 D H H H D D D D H D

3452 D H H H D H H H D D

3453 D H H H H D H H D D

3454 D H H H H H D H D D

3455 D H H H H H H D D D

3456 D H H H D D H H D D

3457 D H H H D H D H D D

3458 D H H H D H H D D D

3459 D H H H H D D H D D

3460 D H H H H D H D D D

3461 D H H H H H D D D D

3462 D H H H D D D H D D

3463 D H H H D D H D D D

3464 D H H H D H D D D D

3465 D H H H H D D D D D

3466 D H H H D D D D D D

3467 H D H H D H H H D H

3468 H D H H H D H H D H

3469 H D H H H H D H D H

3470 H D H H H H H D D H

3471 H D H H D D H H D H

3472 H D H H D H D H D H

3473 H D H H D H H D D H

3474 H D H H H D D H D H

3475 H D H H H D H D D H

3476 H D H H H H D D D H

3477 H D H H D D D H D H

3478 H D H H D D H D D H

3523 D D H H D D H D D H

3524 D D H H D H D D D H

3525 D D H H H D D D D H

3526 D D H H D D D D D H

3527 D D H H D H H H H D

3528 D D H H H D H H H D

3529 D D H H H H D H H D

3530 D D H H H H H D H D

3531 D D H H D D H H H D

3532 D D H H D H D H H D

3533 D D H H D H H D H D

3534 D D H H H D D H H D

3535 D D H H H D H D H D

3536 D D H H H H D D H D

3537 D D H H D D D H H D

3538 D D H H D D H D H D

3539 D D H H D H D D H D

3540 D D H H H D D D H D

3541 D D H H D D D D H D

3542 D D H H D H H H D D

3543 D D H H H D H H D D

3544 D D H H H H D H D D

3545 D D H H H H H D D D

3546 D D H H D D H H D D

3547 D D H H D H D H D D

3548 D D H H D H H D D D

3549 D D H H H D D H D D

3550 D D H H H D H D D D

3551 D D H H H H D D D D

3552 D D H H D D D H D D

3553 D D H H D D H D D D

3554 D D H H D H D D D D

3555 D D H H H D D D D D

3556 D D H H D D D D D D

3557 H H D H D H H H D H

3558 H H D H H D H H D H

3559 H H D H H H D H D H

3560 H H D H H H H D D H

3561 H H D H D D H H D H

3562 H H D H D H D H D H

3563 H H D H D H H D D H

3564 H H D H H D D H D H

3565 H H D H H D H D D H

3566 H H D H H H D D D H No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

3567 H H D H D D D H D H

3568 H H D H D D H D D H

3569 H H D H D H D D D H

3570 H H D H H D D D D H

3571 H H D H D D D D D H

3572 H H D H D H H H H D

3573 H H D H H D H H H D

3574 H H D H H H D H H D

3575 H H D H H H H D H D

3576 H H D H D D H H H D

3577 H H D H D H D H H D

3578 H H D H D H H D H D

3579 H H D H H D D H H D

3580 H H D H H D H D H D

3581 H H D H H H D D H D

3582 H H D H D D D H H D

3583 H H D H D D H D H D

3584 H H D H D H D D H D

3585 H H D H H D D D H D

3586 H H D H D D D D H D

3587 H H D H D H H H D D

3588 H H D H H D H H D D

3589 H H D H H H D H D D

3590 H H D H H H H D D D

3591 H H D H D D H H D D

3592 H H D H D H D H D D

3593 H H D H D H H D D D

3594 H H D H H D D H D D

3595 H H D H H D H D D D

3596 H H D H H H D D D D

3597 H H D H D D D H D D

3598 H H D H D D H D D D

3599 H H D H D H D D D D

3600 H H D H H D D D D D

3601 H H D H D D D D D D

3602 H H H D D H H H D H

3603 H H H D H D H H D H

3604 H H H D H H D H D H

3605 H H H D H H H D D H

3606 H H H D D D H H D H

3607 H H H D D H D H D H

3608 H H H D D H H D D H

3609 H H H D H D D H D H

3610 H H H D H D H D D H No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

361 1 H H H D H H D D D H

3612 H H H D D D D H D H

3613 H H H D D D H D D H

3614 H H H D D H D D D H

3615 H H H D H D D D D H

3616 H H H D D D D D D H

3617 H H H D D H H H H D

3618 H H H D H D H H H D

3619 H H H D H H D H H D

3620 H H H D H H H D H D

3621 H H H D D D H H H D

3622 H H H D D H D H H D

3623 H H H D D H H D H D

3624 H H H D H D D H H D

3625 H H H D H D H D H D

3626 H H H D H H D D H D

3627 H H H D D D D H H D

3628 H H H D D D H D H D

3629 H H H D D H D D H D

3630 H H H D H D D D H D

3631 H H H D D D D D H D

3632 H H H D D H H H D D

3633 H H H D H D H H D D

3634 H H H D H H D H D D

3635 H H H D H H H D D D

3636 H H H D D D H H D D

3637 H H H D D H D H D D

3638 H H H D D H H D D D

3639 H H H D H D D H D D

3640 H H H D H D H D D D

3641 H H H D H H D D D D

3642 H H H D D D D H D D

3643 H H H D D D H D D D

3644 H H H D D H D D D D

3645 H H H D H D D D D D

3646 H H H D D D D D D D

3647 H H D D D H H H D H

3648 H H D D H D H H D H

3649 H H D D H H D H D H

3650 H H D D H H H D D H

3651 H H D D D D H H D H

3652 H H D D D H D H D H

3653 H H D D D H H D D H

3654 H H D D H D D H D H No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

3655 H H D D H D H D D H

3656 H H D D H H D D D H

3657 H H D D D D D H D H

3658 H H D D D D H D D H

3659 H H D D D H D D D H

3660 H H D D H D D D D H

3661 H H D D D D D D D H

3662 H H D D D H H H H D

3663 H H D D H D H H H D

3664 H H D D H H D H H D

3665 H H D D H H H D H D

3666 H H D D D D H H H D

3667 H H D D D H D H H D

3668 H H D D D H H D H D

3669 H H D D H D D H H D

3670 H H D D H D H D H D

3671 H H D D H H D D H D

3672 H H D D D D D H H D

3673 H H D D D D H D H D

3674 H H D D D H D D H D

3675 H H D D H D D D H D

3676 H H D D D D D D H D

3677 H H D D D H H H D D

3678 H H D D H D H H D D

3679 H H D D H H D H D D

3680 H H D D H H H D D D

3681 H H D D D D H H D D

3682 H H D D D H D H D D

3683 H H D D D H H D D D

3684 H H D D H D D H D D

3685 H H D D H D H D D D

3686 H H D D H H D D D D

3687 H H D D D D D H D D

3688 H H D D D D H D D D

3689 H H D D D H D D D D

3690 H H D D H D D D D D

3691 H H D D D D D D D D

3692 D H D H D H H H D H

3693 D H D H H D H H D H

3694 D H D H H H D H D H

3695 D H D H H H H D D H

3696 D H D H D D H H D H

3697 D H D H D H D H D H

3698 D H D H D H H D D H No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

3699 D H D H H D D H D H

3700 D H D H H D H D D H

3701 D H D H H H D D D H

3702 D H D H D D D H D H

3703 D H D H D D H D D H

3704 D H D H D H D D D H

3705 D H D H H D D D D H

3706 D H D H D D D D D H

3707 D H H D D H H H D H

3708 D H H D H D H H D H

3709 D H H D H H D H D H

3710 D H H D H H H D D H

371 1 D H H D D D H H D H

3712 D H H D D H D H D H

3713 D H H D D H H D D H

3714 D H H D H D D H D H

3715 D H H D H D H D D H

3716 D H H D H H D D D H

3717 D H H D D D D H D H

3718 D H H D D D H D D H

3719 D H H D D H D D D H

3720 D H H D H D D D D H

3721 D H H D D D D D D H

3722 D H D D D H H H D H

3723 D H D D H D H H D H

3724 D H D D H H D H D H

3725 D H D D H H H D D H

3726 D H D D D D H H D H

3727 D H D D D H D H D H

3728 D H D D D H H D D H

3729 D H D D H D D H D H

3730 D H D D H D H D D H

3731 D H D D H H D D D H

3732 D H D D D D D H D H

3733 D H D D D D H D D H

3734 D H D D D H D D D H

3735 D H D D H D D D D H

3736 D H D D D D D D D H

3737 H D D H D H H H D H

3738 H D D H H D H H D H

3739 H D D H H H D H D H

3740 H D D H H H H D D H

3741 H D D H D D H H D H

3742 H D D H D H D H D H No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

3743 H D D H D H H D D H

3744 H D D H H D D H D H

3745 H D D H H D H D D H

3746 H D D H H H D D D H

3747 H D D H D D D H D H

3748 H D D H D D H D D H

3749 H D D H D H D D D H

3750 H D D H H D D D D H

3751 H D D H D D D D D H

3752 H D H D D H H H D H

3753 H D H D H D H H D H

3754 H D H D H H D H D H

3755 H D H D H H H D D H

3756 H D H D D D H H D H

3757 H D H D D H D H D H

3758 H D H D D H H D D H

3759 H D H D H D D H D H

3760 H D H D H D H D D H

3761 H D H D H H D D D H

3762 H D H D D D D H D H

3763 H D H D D D H D D H

3764 H D H D D H D D D H

3765 H D H D H D D D D H

3766 H D H D D D D D D H

3767 H D D D D H H H D H

3768 H D D D H D H H D H

3769 H D D D H H D H D H

3770 H D D D H H H D D H

3771 H D D D D D H H D H

3772 H D D D D H D H D H

3773 H D D D D H H D D H

3774 H D D D H D D H D H

3775 H D D D H D H D D H

3776 H D D D H H D D D H

3777 H D D D D D D H D H

3778 H D D D D D H D D H

3779 H D D D D H D D D H

3780 H D D D H D D D D H

3781 H D D D D D D D D H

3782 D D D H D H H H D H

3783 D D D H H D H H D H

3784 D D D H H H D H D H

3785 D D D H H H H D D H

3786 D D D H D D H H D H

3919 D D D H H H D H H D

3920 D D D H H H H D H D

3921 D D D H D D H H H D

3922 D D D H D H D H H D

3923 D D D H D H H D H D

3924 D D D H H D D H H D

3925 D D D H H D H D H D

3926 D D D H H H D D H D

3927 D D D H D D D H H D

3928 D D D H D D H D H D

3929 D D D H D H D D H D

3930 D D D H H D D D H D

3931 D D D H D D D D H D

3932 D D H D D H H H H D

3933 D D H D H D H H H D

3934 D D H D H H D H H D

3935 D D H D H H H D H D

3936 D D H D D D H H H D

3937 D D H D D H D H H D

3938 D D H D D H H D H D

3939 D D H D H D D H H D

3940 D D H D H D H D H D

3941 D D H D H H D D H D

3942 D D H D D D D H H D

3943 D D H D D D H D H D

3944 D D H D D H D D H D

3945 D D H D H D D D H D

3946 D D H D D D D D H D

3947 D D D D D H H H H D

3948 D D D D H D H H H D

3949 D D D D H H D H H D

3950 D D D D H H H D H D

3951 D D D D D D H H H D

3952 D D D D D H D H H D

3953 D D D D D H H D H D

3954 D D D D H D D H H D

3955 D D D D H D H D H D

3956 D D D D H H D D H D

3957 D D D D D D D H H D

3958 D D D D D D H D H D

3959 D D D D D H D D H D

3960 D D D D H D D D H D

3961 D D D D D D D D H D

3962 D H D H D H H H D D No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R⁵"'^'

3963 D H D H H D H H D D

3964 D H D H H H D H D D

3965 D H D H H H H D D D

3966 D H D H D D H H D D

3967 D H D H D H D H D D

3968 D H D H D H H D D D

3969 D H D H H D D H D D

3970 D H D H H D H D D D

3971 D H D H H H D D D D

3972 D H D H D D D H D D

3973 D H D H D D H D D D

3974 D H D H D H D D D D

3975 D H D H H D D D D D

3976 D H D H D D D D D D

3977 D H H D D H H H D D

3978 D H H D H D H H D D

3979 D H H D H H D H D D

3980 D H H D H H H D D D

3981 D H H D D D H H D D

3982 D H H D D H D H D D

3983 D H H D D H H D D D

3984 D H H D H D D H D D

3985 D H H D H D H D D D

3986 D H H D H H D D D D

3987 D H H D D D D H D D

3988 D H H D D D H D D D

3989 D H H D D H D D D D

3990 D H H D H D D D D D

3991 D H H D D D D D D D

3992 D H D D D H H H D D

3993 D H D D H D H H D D

3994 D H D D H H D H D D

3995 D H D D H H H D D D

3996 D H D D D D H H D D

3997 D H D D D H D H D D

3998 D H D D D H H D D D

3999 D H D D H D D H D D

4000 D H D D H D H D D D

4001 D H D D H H D D D D

4002 D H D D D D D H D D

4003 D H D D D D H D D D

4004 D H D D D H D D D D

4005 D H D D H D D D D D

4006 D H D D D D D D D D

No. R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b' _Rxa _Rxb _Rxb^< _Rxc _Ry_a/Rya R^yl7R^yb'

4095 D D D D H D D D D D

4096 D D D D D D D D D D

[0042] In some embodiments of Formula I, each of R^xa, R^x , R^{x '}, R^xc, R^ya, R^ya', R^y and R^{y '} is hydrogen. Accordingly, in some embodiments, the present invention provides a compound of Formula IV:

IV

harmaceutically acceptable salt thereof, wherein: -R^{1 b}

R 1 c

_R2a

2b

R² is R^:

_R3a

^R^: 3b

R is R^JC ; and

each of R^la, R^l , R^lc, R^2a, R² , R^2c, R^3a, R³ , R^3c, R⁴, R^4', R^4", R⁵, R⁶, R^6', R⁷, R^7', R^8a, R^8a', R⁸ , R^{8 '}, R^9a, R^9a', and R⁹ is as defined herein, provided that at least one of R^la, R^l , R^lc, R^2a,

_R2b _R2c _R3a _R3b _R3c _R4 _R4' _r4" _r5 _r6 _r6' _r7 _r7 _R8a _R8a' _R8b _R8b' _R9a _R9a' _R9b is deuterium. [0043] In some embodiments of Formula IV, the compound is selected from those in Table 9 and Table 10.

Table 9. Compounds of Formula IV, wherein R⁵ is H.

No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b'

IV-39 CD₃ CH₃ CD₃ H H D H H H H

IV-40 CD₃ CH₃ CD₃ D D H H H H H

IV-41 CD₃ CH₃ CD₃ D H D H H H H

IV-42 CD₃ CH₃ CD₃ H D D H H H H

IV-43 CD₃ CH₃ CD₃ D D D H H H H

IV-44 CH₃ CD₃ CD₃ D H H H H H H

IV-45 CH₃ CD₃ CD₃ H D H H H H H

IV-46 CH₃ CD₃ CD₃ H H D H H H H

IV-47 CH₃ CD₃ CD₃ D D H H H H H

IV-48 CH₃ CD₃ CD₃ D H D H H H H

IV-49 CH₃ CD₃ CD₃ H D D H H H H

IV-50 CH₃ CD₃ CD₃ D D D H H H H

IV-51 CD₃ CD₃ CD₃ D H H H H H H

IV-52 CD₃ CH₃ CH₃ H H H D H H H

IV-53 CD₃ CH₃ CH₃ H H H H D H H

IV-54 CD₃ CH₃ CH₃ H H H H H D H

IV-55 CD₃ CH₃ CH₃ H H H H H H D

IV-56 CD₃ CH₃ CH₃ H H H D D H H

IV-57 CD₃ CH₃ CH₃ H H H D H D H

IV-58 CD₃ CH₃ CH₃ H H H D H H D

IV-59 CD₃ CH₃ CH₃ H H H H D D H

IV-60 CD₃ CH₃ CH₃ H H H H D H D

IV-61 CD₃ CH₃ CH₃ H H H H H D D

IV-62 CD₃ CH₃ CH₃ H H H D D D H

IV-63 CD₃ CH₃ CH₃ H H H D D H D

IV-64 CD₃ CH₃ CH₃ H H H D H D D

IV-65 CD₃ CH₃ CH₃ H H H H D D D

IV-66 CD₃ CH₃ CH₃ H H H D D D D

IV-67 CH₃ CD₃ CH₃ H H H D H H H

IV-68 CH₃ CD₃ CH₃ H H H H D H H

IV-69 CH₃ CD₃ CH₃ H H H H H D H

IV-70 CH₃ CD₃ CH₃ H H H H H H D

IV-71 CH₃ CD₃ CH₃ H H H D D H H

IV-72 CH₃ CD₃ CH₃ H H H D H D H

IV-73 CH₃ CD₃ CH₃ H H H D H H D

IV-74 CH₃ CD₃ CH₃ H H H H D D H

IV-75 CH₃ CD₃ CH₃ H H H H D H D

IV-76 CH₃ CD₃ CH₃ H H H H H D D

IV-77 CH₃ CD₃ CH₃ H H H D D D H

IV-78 CH₃ CD₃ CH₃ H H H D D H D

IV-79 CH₃ CD₃ CH₃ H H H D H D D

IV-80 CH₃ CD₃ CH₃ H H H H D D D

IV-81 CH₃ CD₃ CH₃ H H H D D D D

IV-82 CH₃ CH₃ CD₃ H H H D H H H No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b'

IV-83 CH₃ CH₃ CD₃ H H H H D H H

IV-84 CH₃ CH₃ CD₃ H H H H H D H

IV-85 CH₃ CH₃ CD₃ H H H H H H D

IV-86 CH₃ CH₃ CD₃ H H H D D H H

IV-87 CH₃ CH₃ CD₃ H H H D H D H

IV-88 CH₃ CH₃ CD₃ H H H D H H D

IV-89 CH₃ CH₃ CD₃ H H H H D D H

IV-90 CH₃ CH₃ CD₃ H H H H D H D

IV-91 CH₃ CH₃ CD₃ H H H H H D D

IV-92 CH₃ CH₃ CD₃ H H H D D D H

IV-93 CH₃ CH₃ CD₃ H H H D D H D

IV-94 CH₃ CH₃ CD₃ H H H D H D D

IV-95 CH₃ CH₃ CD₃ H H H H D D D

IV-96 CH₃ CH₃ CD₃ H H H D D D D

IV-97 CD₃ CD₃ CH₃ H H H D H H H

IV-98 CD₃ CD₃ CH₃ H H H H D H H

IV-99 CD₃ CD₃ CH₃ H H H H H D H

IV- 100 CD₃ CD₃ CH₃ H H H H H H D

IV-101 CD₃ CD₃ CH₃ H H H D D H H

IV- 102 CD₃ CD₃ CH₃ H H H D H D H

IV- 103 CD₃ CD₃ CH₃ H H H D H H D

IV- 104 CD₃ CD₃ CH₃ H H H H D D H

IV- 105 CD₃ CD₃ CH₃ H H H H D H D

IV- 106 CD₃ CD₃ CH₃ H H H H H D D

IV- 107 CD₃ CD₃ CH₃ H H H D D D H

IV- 108 CD₃ CD₃ CH₃ H H H D D H D

IV- 109 CD₃ CD₃ CH₃ H H H D H D D

IV-110 CD₃ CD₃ CH₃ H H H H D D D

IV-111 CD₃ CD₃ CH₃ H H H D D D D

IV-112 CD₃ CH₃ CD₃ H H H D H H H

IV-113 CD₃ CH₃ CD₃ H H H H D H H

IV-114 CD₃ CH₃ CD₃ H H H H H D H

IV-115 CD₃ CH₃ CD₃ H H H H H H D

IV-116 CD₃ CH₃ CD₃ H H H D D H H

IV-117 CD₃ CH₃ CD₃ H H H D H D H

IV-118 CD₃ CH₃ CD₃ H H H D H H D

IV-119 CD₃ CH₃ CD₃ H H H H D D H

IV- 120 CD₃ CH₃ CD₃ H H H H D H D

IV-121 CD₃ CH₃ CD₃ H H H H H D D

IV- 122 CD₃ CH₃ CD₃ H H H D D D H

IV- 123 CD₃ CH₃ CD₃ H H H D D H D

IV- 124 CD₃ CH₃ CD₃ H H H D H D D

IV- 125 CD₃ CH₃ CD₃ H H H H D D D

IV- 126 CD₃ CH₃ CD₃ H H H D D D D No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b'

IV- 127 CH₃ CD₃ CD₃ H H H D H H H

IV- 128 CH₃ CD₃ CD₃ H H H H D H H

IV- 129 CH₃ CD₃ CD₃ H H H H H D H

IV-130 CH₃ CD₃ CD₃ H H H H H H D

IV-131 CH₃ CD₃ CD₃ H H H D D H H

IV- 132 CH₃ CD₃ CD₃ H H H D H D H

IV-133 CH₃ CD₃ CD₃ H H H D H H D

IV- 134 CH₃ CD₃ CD₃ H H H H D D H

IV-135 CH₃ CD₃ CD₃ H H H H D H D

IV-136 CH₃ CD₃ CD₃ H H H H H D D

IV-137 CH₃ CD₃ CD₃ H H H D D D H

IV-138 CH₃ CD₃ CD₃ H H H D D H D

IV-139 CH₃ CD₃ CD₃ H H H D H D D

IV- 140 CH₃ CD₃ CD₃ H H H H D D D

IV-141 CH₃ CD₃ CD₃ H H H D D D D

IV- 142 CD₃ CH₃ CH₃ D H H D H H H

IV- 143 CD₃ CH₃ CH₃ D H H H D H H

IV- 144 CD₃ CH₃ CH₃ D H H H H D H

IV- 145 CD₃ CH₃ CH₃ D H H H H H D

IV- 146 CD₃ CH₃ CH₃ D H H D D H H

IV- 147 CD₃ CH₃ CH₃ D H H D H D H

IV- 148 CD₃ CH₃ CH₃ D H H D H H D

IV- 149 CD₃ CH₃ CH₃ D H H H D D H

IV- 150 CD₃ CH₃ CH₃ D H H H D H D

IV-151 CD₃ CH₃ CH₃ D H H H H D D

IV- 152 CD₃ CH₃ CH₃ D H H D D D H

IV- 153 CD₃ CH₃ CH₃ D H H D D H D

IV- 154 CD₃ CH₃ CH₃ D H H D H D D

IV-155 CD₃ CH₃ CH₃ D H H H D D D

IV- 156 CD₃ CH₃ CH₃ D H H D D D D

IV- 157 CD₃ CH₃ CH₃ H D H D H H H

IV-158 CD₃ CH₃ CH₃ H D H H D H H

IV- 159 CD₃ CH₃ CH₃ H D H H H D H

IV- 160 CD₃ CH₃ CH₃ H D H H H H D

IV-161 CD₃ CH₃ CH₃ H D H D D H H

IV- 162 CD₃ CH₃ CH₃ H D H D H D H

IV- 163 CD₃ CH₃ CH₃ H D H D H H D

IV- 164 CD₃ CH₃ CH₃ H D H H D D H

IV- 165 CD₃ CH₃ CH₃ H D H H D H D

IV- 166 CD₃ CH₃ CH₃ H D H H H D D

IV- 167 CD₃ CH₃ CH₃ H D H D D D H

IV- 168 CD₃ CH₃ CH₃ H D H D D H D

IV- 169 CD₃ CH₃ CH₃ H D H D H D D

IV- 170 CD₃ CH₃ CH₃ H D H H D D D No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b'

IV-171 CD₃ CH₃ CH₃ H D H D D D D

IV- 172 CD₃ CH₃ CH₃ H H D D H H H

IV- 173 CD₃ CH₃ CH₃ H H D H D H H

IV- 174 CD₃ CH₃ CH₃ H H D H H D H

IV- 175 CD₃ CH₃ CH₃ H H D H H H D

IV- 176 CD₃ CH₃ CH₃ H H D D D H H

IV- 177 CD₃ CH₃ CH₃ H H D D H D H

IV- 178 CD₃ CH₃ CH₃ H H D D H H D

IV- 179 CD₃ CH₃ CH₃ H H D H D D H

IV- 180 CD₃ CH₃ CH₃ H H D H D H D

IV-181 CD₃ CH₃ CH₃ H H D H H D D

IV- 182 CD₃ CH₃ CH₃ H H D D D D H

IV- 183 CD₃ CH₃ CH₃ H H D D D H D

IV- 184 CD₃ CH₃ CH₃ H H D D H D D

IV- 185 CD₃ CH₃ CH₃ H H D H D D D

IV- 186 CD₃ CH₃ CH₃ H H D D D D D

IV- 187 CD₃ CH₃ CH₃ D D H D H H H

IV- 188 CD₃ CH₃ CH₃ D D H H D H H

IV- 189 CD₃ CH₃ CH₃ D D H H H D H

IV- 190 CD₃ CH₃ CH₃ D D H H H H D

IV-191 CD₃ CH₃ CH₃ D D H D D H H

IV- 192 CD₃ CH₃ CH₃ D D H D H D H

IV- 193 CD₃ CH₃ CH₃ D D H D H H D

IV- 194 CD₃ CH₃ CH₃ D D H H D D H

IV- 195 CD₃ CH₃ CH₃ D D H H D H D

IV- 196 CD₃ CH₃ CH₃ D D H H H D D

IV- 197 CD₃ CH₃ CH₃ D D H D D D H

IV- 198 CD₃ CH₃ CH₃ D D H D D H D

IV- 199 CD₃ CH₃ CH₃ D D H D H D D

IV-200 CD₃ CH₃ CH₃ D D H H D D D

IV-201 CD₃ CH₃ CH₃ D D H D D D D

IV-202 CD₃ CH₃ CH₃ D H D D H H H

IV-203 CD₃ CH₃ CH₃ D H D H D H H

IV-204 CD₃ CH₃ CH₃ D H D H H D H

IV-205 CD₃ CH₃ CH₃ D H D H H H D

IV-206 CD₃ CH₃ CH₃ D H D D D H H

IV-207 CD₃ CH₃ CH₃ D H D D H D H

IV-208 CD₃ CH₃ CH₃ D H D D H H D

IV-209 CD₃ CH₃ CH₃ D H D H D D H

IV-210 CD₃ CH₃ CH₃ D H D H D H D

IV-211 CD₃ CH₃ CH₃ D H D H H D D

IV-212 CD₃ CH₃ CH₃ D H D D D D H

IV-213 CD₃ CH₃ CH₃ D H D D D H D

IV-214 CD₃ CH₃ CH₃ D H D D H D D No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b'

IV-215 CD₃ CH₃ CH₃ D H D H D D D

IV-216 CD₃ CH₃ CH₃ D H D D D D D

IV-217 CD₃ CH₃ CH₃ H D D D H H H

IV-218 CD₃ CH₃ CH₃ H D D H D H H

IV-219 CD₃ CH₃ CH₃ H D D H H D H

IV-220 CD₃ CH₃ CH₃ H D D H H H D

IV-221 CD₃ CH₃ CH₃ H D D D D H H

IV-222 CD₃ CH₃ CH₃ H D D D H D H

IV-223 CD₃ CH₃ CH₃ H D D D H H D

IV-224 CD₃ CH₃ CH₃ H D D H D D H

IV-225 CD₃ CH₃ CH₃ H D D H D H D

IV-226 CD₃ CH₃ CH₃ H D D H H D D

IV-227 CD₃ CH₃ CH₃ H D D D D D H

IV-228 CD₃ CH₃ CH₃ H D D D D H D

IV-229 CD₃ CH₃ CH₃ H D D D H D D

IV-230 CD₃ CH₃ CH₃ H D D H D D D

IV-231 CD₃ CH₃ CH₃ H D D D D D D

IV-232 CD₃ CH₃ CH₃ D D D D H H H

IV-233 CD₃ CH₃ CH₃ D D D H D H H

IV-234 CD₃ CH₃ CH₃ D D D H H D H

IV-235 CD₃ CH₃ CH₃ D D D H H H D

IV-236 CD₃ CH₃ CH₃ D D D D D H H

IV-237 CD₃ CH₃ CH₃ D D D D H D H

IV-238 CD₃ CH₃ CH₃ D D D D H H D

IV-239 CD₃ CH₃ CH₃ D D D H D D H

IV-240 CD₃ CH₃ CH₃ D D D H D H D

IV-241 CD₃ CH₃ CH₃ D D D H H D D

IV-242 CD₃ CH₃ CH₃ D D D D D D H

IV-243 CD₃ CH₃ CH₃ D D D D D H D

IV-244 CD₃ CH₃ CH₃ D D D D H D D

IV-245 CD₃ CH₃ CH₃ D D D H D D D

IV-246 CD₃ CH₃ CH₃ D D D D D D D

IV-247 CH₃ CD₃ CH₃ D H H D H H H

IV-248 CH₃ CD₃ CH₃ D H H H D H H

IV-249 CH₃ CD₃ CH₃ D H H H H D H

IV-250 CH₃ CD₃ CH₃ D H H H H H D

IV-251 CH₃ CD₃ CH₃ D H H D D H H

IV-252 CH₃ CD₃ CH₃ D H H D H D H

IV-253 CH₃ CD₃ CH₃ D H H D H H D

IV-254 CH₃ CD₃ CH₃ D H H H D D H

IV-255 CH₃ CD₃ CH₃ D H H H D H D

IV-256 CH₃ CD₃ CH₃ D H H H H D D

IV-257 CH₃ CD₃ CH₃ D H H D D D H

IV-258 CH₃ CD₃ CH₃ D H H D D H D No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b'

IV-259 CH₃ CD₃ CH₃ D H H D H D D

IV-260 CH₃ CD₃ CH₃ D H H H D D D

IV-261 CH₃ CD₃ CH₃ D H H D D D D

IV-262 CH₃ CD₃ CH₃ H D H D H H H

IV-263 CH₃ CD₃ CH₃ H D H H D H H

IV-264 CH₃ CD₃ CH₃ H D H H H D H

IV-265 CH₃ CD₃ CH₃ H D H H H H D

IV-266 CH₃ CD₃ CH₃ H D H D D H H

IV-267 CH₃ CD₃ CH₃ H D H D H D H

IV-268 CH₃ CD₃ CH₃ H D H D H H D

IV-269 CH₃ CD₃ CH₃ H D H H D D H

IV-270 CH₃ CD₃ CH₃ H D H H D H D

IV-271 CH₃ CD₃ CH₃ H D H H H D D

IV-272 CH₃ CD₃ CH₃ H D H D D D H

IV-273 CH₃ CD₃ CH₃ H D H D D H D

IV-274 CH₃ CD₃ CH₃ H D H D H D D

IV-275 CH₃ CD₃ CH₃ H D H H D D D

IV-276 CH₃ CD₃ CH₃ H D H D D D D

IV-277 CH₃ CD₃ CH₃ H H D D H H H

IV-278 CH₃ CD₃ CH₃ H H D H D H H

IV-279 CH₃ CD₃ CH₃ H H D H H D H

IV-280 CH₃ CD₃ CH₃ H H D H H H D

IV-281 CH₃ CD₃ CH₃ H H D D D H H

IV-282 CH₃ CD₃ CH₃ H H D D H D H

IV-283 CH₃ CD₃ CH₃ H H D D H H D

IV-284 CH₃ CD₃ CH₃ H H D H D D H

IV-285 CH₃ CD₃ CH₃ H H D H D H D

IV-286 CH₃ CD₃ CH₃ H H D H H D D

IV-287 CH₃ CD₃ CH₃ H H D D D D H

IV-288 CH₃ CD₃ CH₃ H H D D D H D

IV-289 CH₃ CD₃ CH₃ H H D D H D D

IV-290 CH₃ CD₃ CH₃ H H D H D D D

IV-291 CH₃ CD₃ CH₃ H H D D D D D

IV-292 CH₃ CD₃ CH₃ D D H D H H H

IV-293 CH₃ CD₃ CH₃ D D H H D H H

IV-294 CH₃ CD₃ CH₃ D D H H H D H

IV-295 CH₃ CD₃ CH₃ D D H H H H D

IV-296 CH₃ CD₃ CH₃ D D H D D H H

IV-297 CH₃ CD₃ CH₃ D D H D H D H

IV-298 CH₃ CD₃ CH₃ D D H D H H D

IV-299 CH₃ CD₃ CH₃ D D H H D D H

IV-300 CH₃ CD₃ CH₃ D D H H D H D

IV-301 CH₃ CD₃ CH₃ D D H H H D D

IV-302 CH₃ CD₃ CH₃ D D H D D D H No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b'

IV-303 CH₃ CD₃ CH₃ D D H D D H D

IV-304 CH₃ CD₃ CH₃ D D H D H D D

IV-305 CH₃ CD₃ CH₃ D D H H D D D

IV-306 CH₃ CD₃ CH₃ D D H D D D D

IV-307 CH₃ CD₃ CH₃ D H D D H H H

IV-308 CH₃ CD₃ CH₃ D H D H D H H

IV-309 CH₃ CD₃ CH₃ D H D H H D H

IV-310 CH₃ CD₃ CH₃ D H D H H H D

IV-311 CH₃ CD₃ CH₃ D H D D D H H

IV-312 CH₃ CD₃ CH₃ D H D D H D H

IV-313 CH₃ CD₃ CH₃ D H D D H H D

IV-314 CH₃ CD₃ CH₃ D H D H D D H

IV-315 CH₃ CD₃ CH₃ D H D H D H D

IV-316 CH₃ CD₃ CH₃ D H D H H D D

IV-317 CH₃ CD₃ CH₃ D H D D D D H

IV-318 CH₃ CD₃ CH₃ D H D D D H D

IV-319 CH₃ CD₃ CH₃ D H D D H D D

IV-320 CH₃ CD₃ CH₃ D H D H D D D

IV-321 CH₃ CD₃ CH₃ D H D D D D D

IV-322 CH₃ CD₃ CH₃ H D D D H H H

IV-323 CH₃ CD₃ CH₃ H D D H D H H

IV-324 CH₃ CD₃ CH₃ H D D H H D H

IV-325 CH₃ CD₃ CH₃ H D D H H H D

IV-326 CH₃ CD₃ CH₃ H D D D D H H

IV-327 CH₃ CD₃ CH₃ H D D D H D H

IV-328 CH₃ CD₃ CH₃ H D D D H H D

IV-329 CH₃ CD₃ CH₃ H D D H D D H

IV-330 CH₃ CD₃ CH₃ H D D H D H D

IV-331 CH₃ CD₃ CH₃ H D D H H D D

IV-332 CH₃ CD₃ CH₃ H D D D D D H

IV-333 CH₃ CD₃ CH₃ H D D D D H D

IV-334 CH₃ CD₃ CH₃ H D D D H D D

IV-335 CH₃ CD₃ CH₃ H D D H D D D

IV-336 CH₃ CD₃ CH₃ H D D D D D D

IV-337 CH₃ CD₃ CH₃ D D D D H H H

IV-338 CH₃ CD₃ CH₃ D D D H D H H

IV-339 CH₃ CD₃ CH₃ D D D H H D H

IV-340 CH₃ CD₃ CH₃ D D D H H H D

IV-341 CH₃ CD₃ CH₃ D D D D D H H

IV-342 CH₃ CD₃ CH₃ D D D D H D H

IV-343 CH₃ CD₃ CH₃ D D D D H H D

IV-344 CH₃ CD₃ CH₃ D D D H D D H

IV-345 CH₃ CD₃ CH₃ D D D H D H D

IV-346 CH₃ CD₃ CH₃ D D D H H D D No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b'

IV-347 CH₃ CD₃ CH₃ D D D D D D H

IV-348 CH₃ CD₃ CH₃ D D D D D H D

IV-349 CH₃ CD₃ CH₃ D D D D H D D

IV-350 CH₃ CD₃ CH₃ D D D H D D D

IV-351 CH₃ CD₃ CH₃ D D D D D D D

IV-352 CH₃ CH₃ CD₃ D H H D H H H

IV-353 CH₃ CH₃ CD₃ D H H H D H H

IV-354 CH₃ CH₃ CD₃ D H H H H D H

IV-355 CH₃ CH₃ CD₃ D H H H H H D

IV-356 CH₃ CH₃ CD₃ D H H D D H H

IV-357 CH₃ CH₃ CD₃ D H H D H D H

IV-358 CH₃ CH₃ CD₃ D H H D H H D

IV-359 CH₃ CH₃ CD₃ D H H H D D H

IV-360 CH₃ CH₃ CD₃ D H H H D H D

IV-361 CH₃ CH₃ CD₃ D H H H H D D

IV-362 CH₃ CH₃ CD₃ D H H D D D H

IV-363 CH₃ CH₃ CD₃ D H H D D H D

IV-364 CH₃ CH₃ CD₃ D H H D H D D

IV-365 CH₃ CH₃ CD₃ D H H H D D D

IV-366 CH₃ CH₃ CD₃ D H H D D D D

IV-367 CH₃ CH₃ CD₃ H D H D H H H

IV-368 CH₃ CH₃ CD₃ H D H H D H H

IV-369 CH₃ CH₃ CD₃ H D H H H D H

IV-370 CH₃ CH₃ CD₃ H D H H H H D

IV-371 CH₃ CH₃ CD₃ H D H D D H H

IV-372 CH₃ CH₃ CD₃ H D H D H D H

IV-373 CH₃ CH₃ CD₃ H D H D H H D

IV-374 CH₃ CH₃ CD₃ H D H H D D H

IV-375 CH₃ CH₃ CD₃ H D H H D H D

IV-376 CH₃ CH₃ CD₃ H D H H H D D

IV-377 CH₃ CH₃ CD₃ H D H D D D H

IV-378 CH₃ CH₃ CD₃ H D H D D H D

IV-379 CH₃ CH₃ CD₃ H D H D H D D

IV-380 CH₃ CH₃ CD₃ H D H H D D D

IV-381 CH₃ CH₃ CD₃ H D H D D D D

IV-382 CH₃ CH₃ CD₃ H H D D H H H

IV-383 CH₃ CH₃ CD₃ H H D H D H H

IV-384 CH₃ CH₃ CD₃ H H D H H D H

IV-385 CH₃ CH₃ CD₃ H H D H H H D

IV-386 CH₃ CH₃ CD₃ H H D D D H H

IV-387 CH₃ CH₃ CD₃ H H D D H D H

IV-388 CH₃ CH₃ CD₃ H H D D H H D

IV-389 CH₃ CH₃ CD₃ H H D H D D H

IV-390 CH₃ CH₃ CD₃ H H D H D H D No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b'

IV-391 CH₃ CH₃ CD₃ H H D H H D D

IV-392 CH₃ CH₃ CD₃ H H D D D D H

IV-393 CH₃ CH₃ CD₃ H H D D D H D

IV-394 CH₃ CH₃ CD₃ H H D D H D D

IV-395 CH₃ CH₃ CD₃ H H D H D D D

IV-396 CH₃ CH₃ CD₃ H H D D D D D

IV-397 CH₃ CH₃ CD₃ D D H D H H H

IV-398 CH₃ CH₃ CD₃ D D H H D H H

IV-399 CH₃ CH₃ CD₃ D D H H H D H

IV-400 CH₃ CH₃ CD₃ D D H H H H D

IV-401 CH₃ CH₃ CD₃ D D H D D H H

IV-402 CH₃ CH₃ CD₃ D D H D H D H

IV-403 CH₃ CH₃ CD₃ D D H D H H D

IV-404 CH₃ CH₃ CD₃ D D H H D D H

IV-405 CH₃ CH₃ CD₃ D D H H D H D

IV-406 CH₃ CH₃ CD₃ D D H H H D D

IV-407 CH₃ CH₃ CD₃ D D H D D D H

IV-408 CH₃ CH₃ CD₃ D D H D D H D

IV-409 CH₃ CH₃ CD₃ D D H D H D D

IV-410 CH₃ CH₃ CD₃ D D H H D D D

IV-411 CH₃ CH₃ CD₃ D D H D D D D

IV-412 CH₃ CH₃ CD₃ D H D D H H H

IV-413 CH₃ CH₃ CD₃ D H D H D H H

IV-414 CH₃ CH₃ CD₃ D H D H H D H

IV-415 CH₃ CH₃ CD₃ D H D H H H D

IV-416 CH₃ CH₃ CD₃ D H D D D H H

IV-417 CH₃ CH₃ CD₃ D H D D H D H

IV-418 CH₃ CH₃ CD₃ D H D D H H D

IV-419 CH₃ CH₃ CD₃ D H D H D D H

IV-420 CH₃ CH₃ CD₃ D H D H D H D

IV-421 CH₃ CH₃ CD₃ D H D H H D D

IV-422 CH₃ CH₃ CD₃ D H D D D D H

IV-423 CH₃ CH₃ CD₃ D H D D D H D

IV-424 CH₃ CH₃ CD₃ D H D D H D D

IV-425 CH₃ CH₃ CD₃ D H D H D D D

IV-426 CH₃ CH₃ CD₃ D H D D D D D

IV-427 CH₃ CH₃ CD₃ H D D D H H H

IV-428 CH₃ CH₃ CD₃ H D D H D H H

IV-429 CH₃ CH₃ CD₃ H D D H H D H

IV-430 CH₃ CH₃ CD₃ H D D H H H D

IV-431 CH₃ CH₃ CD₃ H D D D D H H

IV-432 CH₃ CH₃ CD₃ H D D D H D H

IV-433 CH₃ CH₃ CD₃ H D D D H H D

IV-434 CH₃ CH₃ CD₃ H D D H D D H No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b'

IV-435 CH₃ CH₃ CD₃ H D D H D H D

IV-436 CH₃ CH₃ CD₃ H D D H H D D

IV-437 CH₃ CH₃ CD₃ H D D D D D H

IV-438 CH₃ CH₃ CD₃ H D D D D H D

IV-439 CH₃ CH₃ CD₃ H D D D H D D

IV-440 CH₃ CH₃ CD₃ H D D H D D D

IV-441 CH₃ CH₃ CD₃ H D D D D D D

IV-442 CH₃ CH₃ CD₃ D D D D H H H

IV-443 CH₃ CH₃ CD₃ D D D H D H H

IV-444 CH₃ CH₃ CD₃ D D D H H D H

IV-445 CH₃ CH₃ CD₃ D D D H H H D

IV-446 CH₃ CH₃ CD₃ D D D D D H H

IV-447 CH₃ CH₃ CD₃ D D D D H D H

IV-448 CH₃ CH₃ CD₃ D D D D H H D

IV-449 CH₃ CH₃ CD₃ D D D H D D H

IV-450 CH₃ CH₃ CD₃ D D D H D H D

IV-451 CH₃ CH₃ CD₃ D D D H H D D

IV-452 CH₃ CH₃ CD₃ D D D D D D H

IV-453 CH₃ CH₃ CD₃ D D D D D H D

IV-454 CH₃ CH₃ CD₃ D D D D H D D

IV-455 CH₃ CH₃ CD₃ D D D H D D D

IV-456 CH₃ CH₃ CD₃ D D D D D D D

IV-457 CD₃ CD₃ CH₃ D H H D H H H

IV-458 CD₃ CD₃ CH₃ D H H H D H H

IV-459 CD₃ CD₃ CH₃ D H H H H D H

IV-460 CD₃ CD₃ CH₃ D H H H H H D

IV-461 CD₃ CD₃ CH₃ D H H D D H H

IV-462 CD₃ CD₃ CH₃ D H H D H D H

IV-463 CD₃ CD₃ CH₃ D H H D H H D

IV-464 CD₃ CD₃ CH₃ D H H H D D H

IV-465 CD₃ CD₃ CH₃ D H H H D H D

IV-466 CD₃ CD₃ CH₃ D H H H H D D

IV-467 CD₃ CD₃ CH₃ D H H D D D H

IV-468 CD₃ CD₃ CH₃ D H H D D H D

IV-469 CD₃ CD₃ CH₃ D H H D H D D

IV-470 CD₃ CD₃ CH₃ D H H H D D D

IV-471 CD₃ CD₃ CH₃ D H H D D D D

IV-472 CD₃ CD₃ CH₃ H D H D H H H

IV-473 CD₃ CD₃ CH₃ H D H H D H H

IV-474 CD₃ CD₃ CH₃ H D H H H D H

IV-475 CD₃ CD₃ CH₃ H D H H H H D

IV-476 CD₃ CD₃ CH₃ H D H D D H H

IV-477 CD₃ CD₃ CH₃ H D H D H D H

IV-478 CD₃ CD₃ CH₃ H D H D H H D No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b'

IV-479 CD₃ CD₃ CH₃ H D H H D D H

IV-480 CD₃ CD₃ CH₃ H D H H D H D

IV-481 CD₃ CD₃ CH₃ H D H H H D D

IV-482 CD₃ CD₃ CH₃ H D H D D D H

IV-483 CD₃ CD₃ CH₃ H D H D D H D

IV-484 CD₃ CD₃ CH₃ H D H D H D D

IV-485 CD₃ CD₃ CH₃ H D H H D D D

IV-486 CD₃ CD₃ CH₃ H D H D D D D

IV-487 CD₃ CD₃ CH₃ H H D D H H H

IV-488 CD₃ CD₃ CH₃ H H D H D H H

IV-489 CD₃ CD₃ CH₃ H H D H H D H

IV-490 CD₃ CD₃ CH₃ H H D H H H D

IV-491 CD₃ CD₃ CH₃ H H D D D H H

IV-492 CD₃ CD₃ CH₃ H H D D H D H

IV-493 CD₃ CD₃ CH₃ H H D D H H D

IV-494 CD₃ CD₃ CH₃ H H D H D D H

IV-495 CD₃ CD₃ CH₃ H H D H D H D

IV-496 CD₃ CD₃ CH₃ H H D H H D D

IV-497 CD₃ CD₃ CH₃ H H D D D D H

IV-498 CD₃ CD₃ CH₃ H H D D D H D

IV-499 CD₃ CD₃ CH₃ H H D D H D D

IV-500 CD₃ CD₃ CH₃ H H D H D D D

IV-501 CD₃ CD₃ CH₃ H H D D D D D

IV-502 CD₃ CD₃ CH₃ D D H D H H H

IV-503 CD₃ CD₃ CH₃ D D H H D H H

IV-504 CD₃ CD₃ CH₃ D D H H H D H

IV-505 CD₃ CD₃ CH₃ D D H H H H D

IV-506 CD₃ CD₃ CH₃ D D H D D H H

IV-507 CD₃ CD₃ CH₃ D D H D H D H

IV-508 CD₃ CD₃ CH₃ D D H D H H D

IV-509 CD₃ CD₃ CH₃ D D H H D D H

IV-510 CD₃ CD₃ CH₃ D D H H D H D

IV-511 CD₃ CD₃ CH₃ D D H H H D D

IV-512 CD₃ CD₃ CH₃ D D H D D D H

IV-513 CD₃ CD₃ CH₃ D D H D D H D

IV-514 CD₃ CD₃ CH₃ D D H D H D D

IV-515 CD₃ CD₃ CH₃ D D H H D D D

IV-516 CD₃ CD₃ CH₃ D D H D D D D

IV-517 CD₃ CD₃ CH₃ D H D D H H H

IV-518 CD₃ CD₃ CH₃ D H D H D H H

IV-519 CD₃ CD₃ CH₃ D H D H H D H

IV-520 CD₃ CD₃ CH₃ D H D H H H D

IV-521 CD₃ CD₃ CH₃ D H D D D H H

IV-522 CD₃ CD₃ CH₃ D H D D H D H No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b'

IV-523 CD₃ CD₃ CH₃ D H D D H H D

IV-524 CD₃ CD₃ CH₃ D H D H D D H

IV-525 CD₃ CD₃ CH₃ D H D H D H D

IV-526 CD₃ CD₃ CH₃ D H D H H D D

IV-527 CD₃ CD₃ CH₃ D H D D D D H

IV-528 CD₃ CD₃ CH₃ D H D D D H D

IV-529 CD₃ CD₃ CH₃ D H D D H D D

IV-530 CD₃ CD₃ CH₃ D H D H D D D

IV-531 CD₃ CD₃ CH₃ D H D D D D D

IV-532 CD₃ CD₃ CH₃ H D D D H H H

IV-533 CD₃ CD₃ CH₃ H D D H D H H

IV-534 CD₃ CD₃ CH₃ H D D H H D H

IV-535 CD₃ CD₃ CH₃ H D D H H H D

IV-536 CD₃ CD₃ CH₃ H D D D D H H

IV-537 CD₃ CD₃ CH₃ H D D D H D H

IV-538 CD₃ CD₃ CH₃ H D D D H H D

IV-539 CD₃ CD₃ CH₃ H D D H D D H

IV-540 CD₃ CD₃ CH₃ H D D H D H D

IV-541 CD₃ CD₃ CH₃ H D D H H D D

IV-542 CD₃ CD₃ CH₃ H D D D D D H

IV-543 CD₃ CD₃ CH₃ H D D D D H D

IV-544 CD₃ CD₃ CH₃ H D D D H D D

IV-545 CD₃ CD₃ CH₃ H D D H D D D

IV-546 CD₃ CD₃ CH₃ H D D D D D D

IV-547 CD₃ CD₃ CH₃ D D D D H H H

IV-548 CD₃ CD₃ CH₃ D D D H D H H

IV-549 CD₃ CD₃ CH₃ D D D H H D H

IV-550 CD₃ CD₃ CH₃ D D D H H H D

IV-551 CD₃ CD₃ CH₃ D D D D D H H

IV-552 CD₃ CD₃ CH₃ D D D D H D H

IV-553 CD₃ CD₃ CH₃ D D D D H H D

IV-554 CD₃ CD₃ CH₃ D D D H D D H

IV-555 CD₃ CD₃ CH₃ D D D H D H D

IV-556 CD₃ CD₃ CH₃ D D D H H D D

IV-557 CD₃ CD₃ CH₃ D D D D D D H

IV-558 CD₃ CD₃ CH₃ D D D D D H D

IV-559 CD₃ CD₃ CH₃ D D D D H D D

IV-560 CD₃ CD₃ CH₃ D D D H D D D

IV-561 CD₃ CD₃ CH₃ D D D D D D D

IV-562 CD₃ CH₃ CD₃ D H H D H H H

IV-563 CD₃ CH₃ CD₃ D H H H D H H

IV-564 CD₃ CH₃ CD₃ D H H H H D H

IV-565 CD₃ CH₃ CD₃ D H H H H H D

IV-566 CD₃ CH₃ CD₃ D H H D D H H No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b'

IV-567 CD₃ CH₃ CD₃ D H H D H D H

IV-568 CD₃ CH₃ CD₃ D H H D H H D

IV-569 CD₃ CH₃ CD₃ D H H H D D H

IV-570 CD₃ CH₃ CD₃ D H H H D H D

IV-571 CD₃ CH₃ CD₃ D H H H H D D

IV-572 CD₃ CH₃ CD₃ D H H D D D H

IV-573 CD₃ CH₃ CD₃ D H H D D H D

IV-574 CD₃ CH₃ CD₃ D H H D H D D

IV-575 CD₃ CH₃ CD₃ D H H H D D D

IV-576 CD₃ CH₃ CD₃ D H H D D D D

IV-577 CD₃ CH₃ CD₃ H D H D H H H

IV-578 CD₃ CH₃ CD₃ H D H H D H H

IV-579 CD₃ CH₃ CD₃ H D H H H D H

IV-580 CD₃ CH₃ CD₃ H D H H H H D

IV-581 CD₃ CH₃ CD₃ H D H D D H H

IV-582 CD₃ CH₃ CD₃ H D H D H D H

IV-583 CD₃ CH₃ CD₃ H D H D H H D

IV-584 CD₃ CH₃ CD₃ H D H H D D H

IV-585 CD₃ CH₃ CD₃ H D H H D H D

IV-586 CD₃ CH₃ CD₃ H D H H H D D

IV-587 CD₃ CH₃ CD₃ H D H D D D H

IV-588 CD₃ CH₃ CD₃ H D H D D H D

IV-589 CD₃ CH₃ CD₃ H D H D H D D

IV-590 CD₃ CH₃ CD₃ H D H H D D D

IV-591 CD₃ CH₃ CD₃ H D H D D D D

IV-592 CD₃ CH₃ CD₃ H H D D H H H

IV-593 CD₃ CH₃ CD₃ H H D H D H H

IV-594 CD₃ CH₃ CD₃ H H D H H D H

IV-595 CD₃ CH₃ CD₃ H H D H H H D

IV-596 CD₃ CH₃ CD₃ H H D D D H H

IV-597 CD₃ CH₃ CD₃ H H D D H D H

IV-598 CD₃ CH₃ CD₃ H H D D H H D

IV-599 CD₃ CH₃ CD₃ H H D H D D H

IV-600 CD₃ CH₃ CD₃ H H D H D H D

IV-601 CD₃ CH₃ CD₃ H H D H H D D

IV-602 CD₃ CH₃ CD₃ H H D D D D H

IV-603 CD₃ CH₃ CD₃ H H D D D H D

IV-604 CD₃ CH₃ CD₃ H H D D H D D

IV-605 CD₃ CH₃ CD₃ H H D H D D D

IV-606 CD₃ CH₃ CD₃ H H D D D D D

IV-607 CD₃ CH₃ CD₃ D D H D H H H

IV-608 CD₃ CH₃ CD₃ D D H H D H H

IV-609 CD₃ CH₃ CD₃ D D H H H D H

IV-610 CD₃ CH₃ CD₃ D D H H H H D No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b'

IV-611 CD₃ CH₃ CD₃ D D H D D H H

IV-612 CD₃ CH₃ CD₃ D D H D H D H

IV-613 CD₃ CH₃ CD₃ D D H D H H D

IV-614 CD₃ CH₃ CD₃ D D H H D D H

IV-615 CD₃ CH₃ CD₃ D D H H D H D

IV-616 CD₃ CH₃ CD₃ D D H H H D D

IV-617 CD₃ CH₃ CD₃ D D H D D D H

IV-618 CD₃ CH₃ CD₃ D D H D D H D

IV-619 CD₃ CH₃ CD₃ D D H D H D D

IV-620 CD₃ CH₃ CD₃ D D H H D D D

IV-621 CD₃ CH₃ CD₃ D D H D D D D

IV-622 CD₃ CH₃ CD₃ D H D D H H H

IV-623 CD₃ CH₃ CD₃ D H D H D H H

IV-624 CD₃ CH₃ CD₃ D H D H H D H

IV-625 CD₃ CH₃ CD₃ D H D H H H D

IV-626 CD₃ CH₃ CD₃ D H D D D H H

IV-627 CD₃ CH₃ CD₃ D H D D H D H

IV-628 CD₃ CH₃ CD₃ D H D D H H D

IV-629 CD₃ CH₃ CD₃ D H D H D D H

IV-630 CD₃ CH₃ CD₃ D H D H D H D

IV-631 CD₃ CH₃ CD₃ D H D H H D D

IV-632 CD₃ CH₃ CD₃ D H D D D D H

IV-633 CD₃ CH₃ CD₃ D H D D D H D

IV-634 CD₃ CH₃ CD₃ D H D D H D D

IV-635 CD₃ CH₃ CD₃ D H D H D D D

IV-636 CD₃ CH₃ CD₃ D H D D D D D

IV-637 CD₃ CH₃ CD₃ H D D D H H H

IV-638 CD₃ CH₃ CD₃ H D D H D H H

IV-639 CD₃ CH₃ CD₃ H D D H H D H

IV-640 CD₃ CH₃ CD₃ H D D H H H D

IV-641 CD₃ CH₃ CD₃ H D D D D H H

IV-642 CD₃ CH₃ CD₃ H D D D H D H

IV-643 CD₃ CH₃ CD₃ H D D D H H D

IV-644 CD₃ CH₃ CD₃ H D D H D D H

IV-645 CD₃ CH₃ CD₃ H D D H D H D

IV-646 CD₃ CH₃ CD₃ H D D H H D D

IV-647 CD₃ CH₃ CD₃ H D D D D D H

IV-648 CD₃ CH₃ CD₃ H D D D D H D

IV-649 CD₃ CH₃ CD₃ H D D D H D D

IV-650 CD₃ CH₃ CD₃ H D D H D D D

IV-651 CD₃ CH₃ CD₃ H D D D D D D

IV-652 CD₃ CH₃ CD₃ D D D D H H H

IV-653 CD₃ CH₃ CD₃ D D D H D H H

IV-654 CD₃ CH₃ CD₃ D D D H H D H No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b'

IV-655 CD₃ CH₃ CD₃ D D D H H H D

IV-656 CD₃ CH₃ CD₃ D D D D D H H

IV-657 CD₃ CH₃ CD₃ D D D D H D H

IV-658 CD₃ CH₃ CD₃ D D D D H H D

IV-659 CD₃ CH₃ CD₃ D D D H D D H

IV-660 CD₃ CH₃ CD₃ D D D H D H D

IV-661 CD₃ CH₃ CD₃ D D D H H D D

IV-662 CD₃ CH₃ CD₃ D D D D D D H

IV-663 CD₃ CH₃ CD₃ D D D D D H D

IV-664 CD₃ CH₃ CD₃ D D D D H D D

IV-665 CD₃ CH₃ CD₃ D D D H D D D

IV-666 CD₃ CH₃ CD₃ D D D D D D D

IV-667 CH₃ CD₃ CD₃ D H H D H H H

IV-668 CH₃ CD₃ CD₃ D H H H D H H

IV-669 CH₃ CD₃ CD₃ D H H H H D H

IV-670 CH₃ CD₃ CD₃ D H H H H H D

IV-671 CH₃ CD₃ CD₃ D H H D D H H

IV-672 CH₃ CD₃ CD₃ D H H D H D H

IV-673 CH₃ CD₃ CD₃ D H H D H H D

IV-674 CH₃ CD₃ CD₃ D H H H D D H

IV-675 CH₃ CD₃ CD₃ D H H H D H D

IV-676 CH₃ CD₃ CD₃ D H H H H D D

IV-677 CH₃ CD₃ CD₃ D H H D D D H

IV-678 CH₃ CD₃ CD₃ D H H D D H D

IV-679 CH₃ CD₃ CD₃ D H H D H D D

IV-680 CH₃ CD₃ CD₃ D H H H D D D

IV-681 CH₃ CD₃ CD₃ D H H D D D D

IV-682 CH₃ CD₃ CD₃ H D H D H H H

IV-683 CH₃ CD₃ CD₃ H D H H D H H

IV-684 CH₃ CD₃ CD₃ H D H H H D H

IV-685 CH₃ CD₃ CD₃ H D H H H H D

IV-686 CH₃ CD₃ CD₃ H D H D D H H

IV-687 CH₃ CD₃ CD₃ H D H D H D H

IV-688 CH₃ CD₃ CD₃ H D H D H H D

IV-689 CH₃ CD₃ CD₃ H D H H D D H

IV-690 CH₃ CD₃ CD₃ H D H H D H D

IV-691 CH₃ CD₃ CD₃ H D H H H D D

IV-692 CH₃ CD₃ CD₃ H D H D D D H

IV-693 CH₃ CD₃ CD₃ H D H D D H D

IV-694 CH₃ CD₃ CD₃ H D H D H D D

IV-695 CH₃ CD₃ CD₃ H D H H D D D

IV-696 CH₃ CD₃ CD₃ H D H D D D D

IV-697 CH₃ CD₃ CD₃ H H D D H H H

IV-698 CH₃ CD₃ CD₃ H H D H D H H No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^a/R*^a R^m/R^m' R^y7R^ya' R^9l7R^9b'

IV-699 CH₃ CD₃ CD₃ H H D H H D H

IV-700 CH₃ CD₃ CD₃ H H D H H H D

IV-701 CH₃ CD₃ CD₃ H H D D D H H

IV-702 CH₃ CD₃ CD₃ H H D D H D H

IV-703 CH₃ CD₃ CD₃ H H D D H H D

IV-704 CH₃ CD₃ CD₃ H H D H D D H

IV-705 CH₃ CD₃ CD₃ H H D H D H D

IV-706 CH₃ CD₃ CD₃ H H D H H D D

IV-707 CH₃ CD₃ CD₃ H H D D D D H

IV-708 CH₃ CD₃ CD₃ H H D D D H D

IV-709 CH₃ CD₃ CD₃ H H D D H D D

IV-710 CH₃ CD₃ CD₃ H H D H D D D

IV-711 CH₃ CD₃ CD₃ H H D D D D D

IV-712 CH₃ CD₃ CD₃ D D H D H H H

IV-713 CH₃ CD₃ CD₃ D D H H D H H

IV-714 CH₃ CD₃ CD₃ D D H H H D H

IV-715 CH₃ CD₃ CD₃ D D H H H H D

IV-716 CH₃ CD₃ CD₃ D D H D D H H

IV-717 CH₃ CD₃ CD₃ D D H D H D H

IV-718 CH₃ CD₃ CD₃ D D H D H H D

IV-719 CH₃ CD₃ CD₃ D D H H D D H

IV-720 CH₃ CD₃ CD₃ D D H H D H D

IV-721 CH₃ CD₃ CD₃ D D H H H D D

IV-722 CH₃ CD₃ CD₃ D D H D D D H

IV-723 CH₃ CD₃ CD₃ D D H D D H D

IV-724 CH₃ CD₃ CD₃ D D H D H D D

IV-725 CH₃ CD₃ CD₃ D D H H D D D

IV-726 CH₃ CD₃ CD₃ D D H D D D D

IV-727 CH₃ CD₃ CD₃ D H D D H H H

IV-728 CH₃ CD₃ CD₃ D H D H D H H

IV-729 CH₃ CD₃ CD₃ D H D H H D H

IV-730 CH₃ CD₃ CD₃ D H D H H H D

IV-731 CH₃ CD₃ CD₃ D H D D D H H

IV-732 CH₃ CD₃ CD₃ D H D D H D H

IV-733 CH₃ CD₃ CD₃ D H D D H H D

IV-734 CH₃ CD₃ CD₃ D H D H D D H

IV-735 CH₃ CD₃ CD₃ D H D H D H D

IV-736 CH₃ CD₃ CD₃ D H D H H D D

IV-737 CH₃ CD₃ CD₃ D H D D D D H

IV-738 CH₃ CD₃ CD₃ D H D D D H D

IV-739 CH₃ CD₃ CD₃ D H D D H D D

IV-740 CH₃ CD₃ CD₃ D H D H D D D

IV-741 CH₃ CD₃ CD₃ D H D D D D D

IV-742 CH₃ CD₃ CD₃ H D D D H H H No. R R R^J R /R /R R⁶/R⁶ R⁷/R⁷ R*^A/R*^A R^m/R^m' R^Y7R^YA' R^Y|>/R^Y|>'

IV-743 CH₃ CD₃ CD₃ H D D H D H H

IV-744 CH₃ CD₃ CD₃ H D D H H D H

IV-745 CH₃ CD₃ CD₃ H D D H H H D

IV-746 CH₃ CD₃ CD₃ H D D D D H H

IV-747 CH₃ CD₃ CD₃ H D D D H D H

IV-748 CH₃ CD₃ CD₃ H D D D H H D

IV-749 CH₃ CD₃ CD₃ H D D H D D H

IV-750 CH₃ CD₃ CD₃ H D D H D H D

IV-751 CH₃ CD₃ CD₃ H D D H H D D

IV-752 CH₃ CD₃ CD₃ H D D D D D H

IV-753 CH₃ CD₃ CD₃ H D D D D H D

IV-754 CH₃ CD₃ CD₃ H D D D H D D

IV-755 CH₃ CD₃ CD₃ H D D H D D D

IV-756 CH₃ CD₃ CD₃ H D D D D D D

IV-757 CH₃ CD₃ CD₃ D D D D H H H

IV-758 CH₃ CD₃ CD₃ D D D H D H H

IV-759 CH₃ CD₃ CD₃ D D D H H D H

IV-760 CH₃ CD₃ CD₃ D D D H H H D

IV-761 CH₃ CD₃ CD₃ D D D D D H H

IV-762 CH₃ CD₃ CD₃ D D D D H D H

IV-763 CH₃ CD₃ CD₃ D D D D H H D

IV-764 CH₃ CD₃ CD₃ D D D H D D H

IV-765 CH₃ CD₃ CD₃ D D D H D H D

IV-766 CH₃ CD₃ CD₃ D D D H H D D

IV-767 CH₃ CD₃ CD₃ D D D D D D H

IV-768 CH₃ CD₃ CD₃ D D D D D H D

IV-769 CH₃ CD₃ CD₃ D D D D H D D

IV-770 CH₃ CD₃ CD₃ D D D H D D D

IV-771 CH₃ CD₃ CD₃ D D D D D D D

Table 10. Compounds of Formula IV, wherein R⁵ is D.

No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9L7R^9B'

IV-782 CD₃ CH₃ CH₃ H D H H H H H

IV-783 CD₃ CH₃ CH₃ H H D H H H H

IV-784 CD₃ CH₃ CH₃ D D H H H H H

IV-785 CD₃ CH₃ CH₃ D H D H H H H

IV-786 CD₃ CH₃ CH₃ H D D H H H H

IV-787 CD₃ CH₃ CH₃ D D D H H H H

IV-788 CH₃ CD₃ CH₃ D H H H H H H

IV-789 CH₃ CD₃ CH₃ H D H H H H H

IV-790 CH₃ CD₃ CH₃ H H D H H H H

IV-791 CH₃ CD₃ CH₃ D D H H H H H

IV-792 CH₃ CD₃ CH₃ D H D H H H H

IV-793 CH₃ CD₃ CH₃ H D D H H H H

IV-794 CH₃ CD₃ CH₃ D D D H H H H

IV-795 CH₃ CH₃ CD₃ D H H H H H H

IV-796 CH₃ CH₃ CD₃ H D H H H H H

IV-797 CH₃ CH₃ CD₃ H H D H H H H

IV-798 CH₃ CH₃ CD₃ D D H H H H H

IV-799 CH₃ CH₃ CD₃ D H D H H H H

IV-800 CH₃ CH₃ CD₃ H D D H H H H

IV-801 CH₃ CH₃ CD₃ D D D H H H H

IV-802 CD₃ CD₃ CH₃ D H H H H H H

IV-803 CD₃ CD₃ CH₃ H D H H H H H

IV-804 CD₃ CD₃ CH₃ H H D H H H H

IV-805 CD₃ CD₃ CH₃ D D H H H H H

IV-806 CD₃ CD₃ CH₃ D H D H H H H

IV-807 CD₃ CD₃ CH₃ H D D H H H H

IV-808 CD₃ CD₃ CH₃ D D D H H H H

IV-809 CD₃ CH₃ CD₃ D H H H H H H

IV-810 CD₃ CH₃ CD₃ H D H H H H H

IV-811 CD₃ CH₃ CD₃ H H D H H H H

IV-812 CD₃ CH₃ CD₃ D D H H H H H

IV-813 CD₃ CH₃ CD₃ D H D H H H H

IV-814 CD₃ CH₃ CD₃ H D D H H H H

IV-815 CD₃ CH₃ CD₃ D D D H H H H

IV-816 CH₃ CD₃ CD₃ D H H H H H H

IV-817 CH₃ CD₃ CD₃ H D H H H H H

IV-818 CH₃ CD₃ CD₃ H H D H H H H

IV-819 CH₃ CD₃ CD₃ D D H H H H H

IV-820 CH₃ CD₃ CD₃ D H D H H H H

IV-821 CH₃ CD₃ CD₃ H D D H H H H

IV-822 CH₃ CD₃ CD₃ D D D H H H H

IV-823 CD₃ CD₃ CD₃ D H H H H H H

IV-824 CD₃ CH₃ CH₃ H H H D H H H

IV-825 CD₃ CH₃ CH₃ H H H H D H H No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9L7R^9B'

IV-826 CD₃ CH₃ CH₃ H H H H H D H

IV-827 CD₃ CH₃ CH₃ H H H H H H D

IV-828 CD₃ CH₃ CH₃ H H H D D H H

IV-829 CD₃ CH₃ CH₃ H H H D H D H

IV-830 CD₃ CH₃ CH₃ H H H D H H D

IV-831 CD₃ CH₃ CH₃ H H H H D D H

IV-832 CD₃ CH₃ CH₃ H H H H D H D

IV-833 CD₃ CH₃ CH₃ H H H H H D D

IV-834 CD₃ CH₃ CH₃ H H H D D D H

IV-835 CD₃ CH₃ CH₃ H H H D D H D

IV-836 CD₃ CH₃ CH₃ H H H D H D D

IV-837 CD₃ CH₃ CH₃ H H H H D D D

IV-838 CD₃ CH₃ CH₃ H H H D D D D

IV-839 CH₃ CD₃ CH₃ H H H D H H H

IV-840 CH₃ CD₃ CH₃ H H H H D H H

IV-841 CH₃ CD₃ CH₃ H H H H H D H

IV-842 CH₃ CD₃ CH₃ H H H H H H D

IV-843 CH₃ CD₃ CH₃ H H H D D H H

IV-844 CH₃ CD₃ CH₃ H H H D H D H

IV-845 CH₃ CD₃ CH₃ H H H D H H D

IV-846 CH₃ CD₃ CH₃ H H H H D D H

IV-847 CH₃ CD₃ CH₃ H H H H D H D

IV-848 CH₃ CD₃ CH₃ H H H H H D D

IV-849 CH₃ CD₃ CH₃ H H H D D D H

IV-850 CH₃ CD₃ CH₃ H H H D D H D

IV-851 CH₃ CD₃ CH₃ H H H D H D D

IV-852 CH₃ CD₃ CH₃ H H H H D D D

IV-853 CH₃ CD₃ CH₃ H H H D D D D

IV-854 CH₃ CH₃ CD₃ H H H D H H H

IV-855 CH₃ CH₃ CD₃ H H H H D H H

IV-856 CH₃ CH₃ CD₃ H H H H H D H

IV-857 CH₃ CH₃ CD₃ H H H H H H D

IV-858 CH₃ CH₃ CD₃ H H H D D H H

IV-859 CH₃ CH₃ CD₃ H H H D H D H

IV-860 CH₃ CH₃ CD₃ H H H D H H D

IV-861 CH₃ CH₃ CD₃ H H H H D D H

IV-862 CH₃ CH₃ CD₃ H H H H D H D

IV-863 CH₃ CH₃ CD₃ H H H H H D D

IV-864 CH₃ CH₃ CD₃ H H H D D D H

IV-865 CH₃ CH₃ CD₃ H H H D D H D

IV-866 CH₃ CH₃ CD₃ H H H D H D D

IV-867 CH₃ CH₃ CD₃ H H H H D D D

IV-868 CH₃ CH₃ CD₃ H H H D D D D

IV-869 CD₃ CD₃ CH₃ H H H D H H H No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9L7R^9B'

IV-870 CD₃ CD₃ CH₃ H H H H D H H

IV-871 CD₃ CD₃ CH₃ H H H H H D H

IV-872 CD₃ CD₃ CH₃ H H H H H H D

IV-873 CD₃ CD₃ CH₃ H H H D D H H

IV-874 CD₃ CD₃ CH₃ H H H D H D H

IV-875 CD₃ CD₃ CH₃ H H H D H H D

IV-876 CD₃ CD₃ CH₃ H H H H D D H

IV-877 CD₃ CD₃ CH₃ H H H H D H D

IV-878 CD₃ CD₃ CH₃ H H H H H D D

IV-879 CD₃ CD₃ CH₃ H H H D D D H

IV-880 CD₃ CD₃ CH₃ H H H D D H D

IV-881 CD₃ CD₃ CH₃ H H H D H D D

IV-882 CD₃ CD₃ CH₃ H H H H D D D

IV-883 CD₃ CD₃ CH₃ H H H D D D D

IV-884 CD₃ CH₃ CD₃ H H H D H H H

IV-885 CD₃ CH₃ CD₃ H H H H D H H

IV-886 CD₃ CH₃ CD₃ H H H H H D H

IV-887 CD₃ CH₃ CD₃ H H H H H H D

IV-888 CD₃ CH₃ CD₃ H H H D D H H

IV-889 CD₃ CH₃ CD₃ H H H D H D H

IV-890 CD₃ CH₃ CD₃ H H H D H H D

IV-891 CD₃ CH₃ CD₃ H H H H D D H

IV-892 CD₃ CH₃ CD₃ H H H H D H D

IV-893 CD₃ CH₃ CD₃ H H H H H D D

IV-894 CD₃ CH₃ CD₃ H H H D D D H

IV-895 CD₃ CH₃ CD₃ H H H D D H D

IV-896 CD₃ CH₃ CD₃ H H H D H D D

IV-897 CD₃ CH₃ CD₃ H H H H D D D

IV-898 CD₃ CH₃ CD₃ H H H D D D D

IV-899 CH₃ CD₃ CD₃ H H H D H H H

IV-900 CH₃ CD₃ CD₃ H H H H D H H

IV-901 CH₃ CD₃ CD₃ H H H H H D H

IV-902 CH₃ CD₃ CD₃ H H H H H H D

IV-903 CH₃ CD₃ CD₃ H H H D D H H

IV-904 CH₃ CD₃ CD₃ H H H D H D H

IV-905 CH₃ CD₃ CD₃ H H H D H H D

IV-906 CH₃ CD₃ CD₃ H H H H D D H

IV-907 CH₃ CD₃ CD₃ H H H H D H D

IV-908 CH₃ CD₃ CD₃ H H H H H D D

IV-909 CH₃ CD₃ CD₃ H H H D D D H

IV-910 CH₃ CD₃ CD₃ H H H D D H D

IV-911 CH₃ CD₃ CD₃ H H H D H D D

IV-912 CH₃ CD₃ CD₃ H H H H D D D

IV-913 CH₃ CD₃ CD₃ H H H D D D D No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9L7R^9B'

IV-914 CD₃ CH₃ CH₃ D H H D H H H

IV-915 CD₃ CH₃ CH₃ D H H H D H H

IV-916 CD₃ CH₃ CH₃ D H H H H D H

IV-917 CD₃ CH₃ CH₃ D H H H H H D

IV-918 CD₃ CH₃ CH₃ D H H D D H H

IV-919 CD₃ CH₃ CH₃ D H H D H D H

IV-920 CD₃ CH₃ CH₃ D H H D H H D

IV-921 CD₃ CH₃ CH₃ D H H H D D H

IV-922 CD₃ CH₃ CH₃ D H H H D H D

IV-923 CD₃ CH₃ CH₃ D H H H H D D

IV-924 CD₃ CH₃ CH₃ D H H D D D H

IV-925 CD₃ CH₃ CH₃ D H H D D H D

IV-926 CD₃ CH₃ CH₃ D H H D H D D

IV-927 CD₃ CH₃ CH₃ D H H H D D D

IV-928 CD₃ CH₃ CH₃ D H H D D D D

IV-929 CD₃ CH₃ CH₃ H D H D H H H

IV-930 CD₃ CH₃ CH₃ H D H H D H H

IV-931 CD₃ CH₃ CH₃ H D H H H D H

IV-932 CD₃ CH₃ CH₃ H D H H H H D

IV-933 CD₃ CH₃ CH₃ H D H D D H H

IV-934 CD₃ CH₃ CH₃ H D H D H D H

IV-935 CD₃ CH₃ CH₃ H D H D H H D

IV-936 CD₃ CH₃ CH₃ H D H H D D H

IV-937 CD₃ CH₃ CH₃ H D H H D H D

IV-938 CD₃ CH₃ CH₃ H D H H H D D

IV-939 CD₃ CH₃ CH₃ H D H D D D H

IV-940 CD₃ CH₃ CH₃ H D H D D H D

IV-941 CD₃ CH₃ CH₃ H D H D H D D

IV-942 CD₃ CH₃ CH₃ H D H H D D D

IV-943 CD₃ CH₃ CH₃ H D H D D D D

IV-944 CD₃ CH₃ CH₃ H H D D H H H

IV-945 CD₃ CH₃ CH₃ H H D H D H H

IV-946 CD₃ CH₃ CH₃ H H D H H D H

IV-947 CD₃ CH₃ CH₃ H H D H H H D

IV-948 CD₃ CH₃ CH₃ H H D D D H H

IV-949 CD₃ CH₃ CH₃ H H D D H D H

IV-950 CD₃ CH₃ CH₃ H H D D H H D

IV-951 CD₃ CH₃ CH₃ H H D H D D H

IV-952 CD₃ CH₃ CH₃ H H D H D H D

IV-953 CD₃ CH₃ CH₃ H H D H H D D

IV-954 CD₃ CH₃ CH₃ H H D D D D H

IV-955 CD₃ CH₃ CH₃ H H D D D H D

IV-956 CD₃ CH₃ CH₃ H H D D H D D

IV-957 CD₃ CH₃ CH₃ H H D H D D D No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9L7R^9B'

IV-958 CD₃ CH₃ CH₃ H H D D D D D

IV-959 CD₃ CH₃ CH₃ D D H D H H H

IV-960 CD₃ CH₃ CH₃ D D H H D H H

IV-961 CD₃ CH₃ CH₃ D D H H H D H

IV-962 CD₃ CH₃ CH₃ D D H H H H D

IV-963 CD₃ CH₃ CH₃ D D H D D H H

IV-964 CD₃ CH₃ CH₃ D D H D H D H

IV-965 CD₃ CH₃ CH₃ D D H D H H D

IV-966 CD₃ CH₃ CH₃ D D H H D D H

IV-967 CD₃ CH₃ CH₃ D D H H D H D

IV-968 CD₃ CH₃ CH₃ D D H H H D D

IV-969 CD₃ CH₃ CH₃ D D H D D D H

IV-970 CD₃ CH₃ CH₃ D D H D D H D

IV-971 CD₃ CH₃ CH₃ D D H D H D D

IV-972 CD₃ CH₃ CH₃ D D H H D D D

IV-973 CD₃ CH₃ CH₃ D D H D D D D

IV-974 CD₃ CH₃ CH₃ D H D D H H H

IV-975 CD₃ CH₃ CH₃ D H D H D H H

IV-976 CD₃ CH₃ CH₃ D H D H H D H

IV-977 CD₃ CH₃ CH₃ D H D H H H D

IV-978 CD₃ CH₃ CH₃ D H D D D H H

IV-979 CD₃ CH₃ CH₃ D H D D H D H

IV-980 CD₃ CH₃ CH₃ D H D D H H D

IV-981 CD₃ CH₃ CH₃ D H D H D D H

IV-982 CD₃ CH₃ CH₃ D H D H D H D

IV-983 CD₃ CH₃ CH₃ D H D H H D D

IV-984 CD₃ CH₃ CH₃ D H D D D D H

IV-985 CD₃ CH₃ CH₃ D H D D D H D

IV-986 CD₃ CH₃ CH₃ D H D D H D D

IV-987 CD₃ CH₃ CH₃ D H D H D D D

IV-988 CD₃ CH₃ CH₃ D H D D D D D

IV-989 CD₃ CH₃ CH₃ H D D D H H H

IV-990 CD₃ CH₃ CH₃ H D D H D H H

IV-991 CD₃ CH₃ CH₃ H D D H H D H

IV-992 CD₃ CH₃ CH₃ H D D H H H D

IV-993 CD₃ CH₃ CH₃ H D D D D H H

IV-994 CD₃ CH₃ CH₃ H D D D H D H

IV-995 CD₃ CH₃ CH₃ H D D D H H D

IV-996 CD₃ CH₃ CH₃ H D D H D D H

IV-997 CD₃ CH₃ CH₃ H D D H D H D

IV-998 CD₃ CH₃ CH₃ H D D H H D D

IV-999 CD₃ CH₃ CH₃ H D D D D D H

IV- 1000 CD₃ CH₃ CH₃ H D D D D H D

IV- 1001 CD₃ CH₃ CH₃ H D D D H D D No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9L7R^9B'

IV- 1002 CD₃ CH₃ CH₃ H D D H D D D

IV- 1003 CD₃ CH₃ CH₃ H D D D D D D

IV- 1004 CD₃ CH₃ CH₃ D D D D H H H

IV- 1005 CD₃ CH₃ CH₃ D D D H D H H

IV- 1006 CD₃ CH₃ CH₃ D D D H H D H

IV- 1007 CD₃ CH₃ CH₃ D D D H H H D

IV- 1008 CD₃ CH₃ CH₃ D D D D D H H

IV- 1009 CD₃ CH₃ CH₃ D D D D H D H

IV- 1010 CD₃ CH₃ CH₃ D D D D H H D

IV- 1011 CD₃ CH₃ CH₃ D D D H D D H

IV-1012 CD₃ CH₃ CH₃ D D D H D H D

IV- 1013 CD₃ CH₃ CH₃ D D D H H D D

IV-1014 CD₃ CH₃ CH₃ D D D D D D H

IV- 1015 CD₃ CH₃ CH₃ D D D D D H D

IV- 1016 CD₃ CH₃ CH₃ D D D D H D D

IV- 1017 CD₃ CH₃ CH₃ D D D H D D D

IV- 1018 CD₃ CH₃ CH₃ D D D D D D D

IV- 1019 CH₃ CD₃ CH₃ D H H D H H H

IV- 1020 CH₃ CD₃ CH₃ D H H H D H H

IV- 1021 CH₃ CD₃ CH₃ D H H H H D H

IV- 1022 CH₃ CD₃ CH₃ D H H H H H D

IV- 1023 CH₃ CD₃ CH₃ D H H D D H H

IV- 1024 CH₃ CD₃ CH₃ D H H D H D H

IV- 1025 CH₃ CD₃ CH₃ D H H D H H D

IV- 1026 CH₃ CD₃ CH₃ D H H H D D H

IV- 1027 CH₃ CD₃ CH₃ D H H H D H D

IV- 1028 CH₃ CD₃ CH₃ D H H H H D D

IV- 1029 CH₃ CD₃ CH₃ D H H D D D H

IV- 1030 CH₃ CD₃ CH₃ D H H D D H D

IV- 1031 CH₃ CD₃ CH₃ D H H D H D D

IV- 1032 CH₃ CD₃ CH₃ D H H H D D D

IV- 1033 CH₃ CD₃ CH₃ D H H D D D D

IV- 1034 CH₃ CD₃ CH₃ H D H D H H H

IV- 1035 CH₃ CD₃ CH₃ H D H H D H H

IV- 1036 CH₃ CD₃ CH₃ H D H H H D H

IV- 1037 CH₃ CD₃ CH₃ H D H H H H D

IV- 1038 CH₃ CD₃ CH₃ H D H D D H H

IV- 1039 CH₃ CD₃ CH₃ H D H D H D H

IV- 1040 CH₃ CD₃ CH₃ H D H D H H D

IV- 1041 CH₃ CD₃ CH₃ H D H H D D H

IV- 1042 CH₃ CD₃ CH₃ H D H H D H D

IV- 1043 CH₃ CD₃ CH₃ H D H H H D D

IV- 1044 CH₃ CD₃ CH₃ H D H D D D H

IV- 1045 CH₃ CD₃ CH₃ H D H D D H D No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9l7R^9b'

IV- 1046 CH₃ CD₃ CH₃ H D H D H D D

IV- 1047 CH₃ CD₃ CH₃ H D H H D D D

IV- 1048 c¾ CD₃ CH₃ H D H D D D D

IV- 1049 c¾ CD₃ CH₃ H H D D H H H

IV- 1050 c¾ CD₃ CH₃ H H D H D H H

IV- 1051 c¾ CD₃ CH₃ H H D H H D H

IV- 1052 c¾ CD₃ CH₃ H H D H H H D

IV- 1053 c¾ CD₃ CH₃ H H D D D H H

IV- 1054 c¾ CD₃ CH₃ H H D D H D H

IV- 1055 c¾ CD₃ CH₃ H H D D H H D

IV- 1056 CH₃ CD₃ CH₃ H H D H D D H

IV- 1057 CH₃ CD₃ CH₃ H H D H D H D

IV- 1058 CH₃ CD₃ CH₃ H H D H H D D

IV- 1059 CH₃ CD₃ CH₃ H H D D D D H

IV- 1060 CH₃ CD₃ CH₃ H H D D D H D

IV- 1061 CH₃ CD₃ CH₃ H H D D H D D

IV- 1062 CH₃ CD₃ CH₃ H H D H D D D

IV- 1063 CH₃ CD₃ CH₃ H H D D D D D

IV- 1064 CH₃ CD₃ CH₃ D D H D H H H

IV- 1065 CH₃ CD₃ CH₃ D D H H D H H

IV- 1066 CH₃ CD₃ CH₃ D D H H H D H

IV- 1067 CH₃ CD₃ CH₃ D D H H H H D

IV- 1068 CH₃ CD₃ CH₃ D D H D D H H

IV- 1069 CH₃ CD₃ CH₃ D D H D H D H

IV- 1070 CH₃ CD₃ CH₃ D D H D H H D

IV- 1071 CH₃ CD₃ CH₃ D D H H D D H

IV- 1072 CH₃ CD₃ CH₃ D D H H D H D

IV- 1073 CH₃ CD₃ CH₃ D D H H H D D

IV- 1074 CH₃ CD₃ CH₃ D D H D D D H

IV- 1075 CH₃ CD₃ CH₃ D D H D D H D

IV- 1076 CH₃ CD₃ CH₃ D D H D H D D

IV- 1077 CH₃ CD₃ CH₃ D D H H D D D

IV- 1078 CH₃ CD₃ CH₃ D D H D D D D

IV- 1079 CH₃ CD₃ CH₃ D H D D H H H

IV- 1080 CH₃ CD₃ CH₃ D H D H D H H

IV- 1081 CH₃ CD₃ CH₃ D H D H H D H

IV- 1082 CH₃ CD₃ CH₃ D H D H H H D

IV- 1083 CH₃ CD₃ CH₃ D H D D D H H

IV- 1084 CH₃ CD₃ CH₃ D H D D H D H

IV- 1085 CH₃ CD₃ CH₃ D H D D H H D

IV- 1086 CH₃ CD₃ CH₃ D H D H D D H

IV- 1087 CH₃ CD₃ CH₃ D H D H D H D

IV- 1088 CH₃ CD₃ CH₃ D H D H H D D

IV- 1089 CH₃ CD₃ CH₃ D H D D D D H No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9L7R^9B'

IV- 1090 CH₃ CD₃ CH₃ D H D D D H D

IV- 1091 CH₃ CD₃ CH₃ D H D D H D D

IV- 1092 CH₃ CD₃ CH₃ D H D H D D D

IV- 1093 CH₃ CD₃ CH₃ D H D D D D D

IV- 1094 CH₃ CD₃ CH₃ H D D D H H H

IV- 1095 CH₃ CD₃ CH₃ H D D H D H H

IV- 1096 CH₃ CD₃ CH₃ H D D H H D H

IV- 1097 CH₃ CD₃ CH₃ H D D H H H D

IV- 1098 CH₃ CD₃ CH₃ H D D D D H H

IV- 1099 CH₃ CD₃ CH₃ H D D D H D H

IV- 1100 CH₃ CD₃ CH₃ H D D D H H D

IV- 1101 CH₃ CD₃ CH₃ H D D H D D H

IV- 1102 CH₃ CD₃ CH₃ H D D H D H D

IV- 1103 CH₃ CD₃ CH₃ H D D H H D D

IV- 1104 CH₃ CD₃ CH₃ H D D D D D H

IV- 1105 CH₃ CD₃ CH₃ H D D D D H D

IV- 1106 CH₃ CD₃ CH₃ H D D D H D D

IV- 1107 CH₃ CD₃ CH₃ H D D H D D D

IV- 1108 CH₃ CD₃ CH₃ H D D D D D D

IV- 1109 CH₃ CD₃ CH₃ D D D D H H H

IV-1110 CH₃ CD₃ CH₃ D D D H D H H

IV-1111 CH₃ CD₃ CH₃ D D D H H D H

IV-1112 CH₃ CD₃ CH₃ D D D H H H D

IV-1113 CH₃ CD₃ CH₃ D D D D D H H

IV-1114 CH₃ CD₃ CH₃ D D D D H D H

IV-1115 CH₃ CD₃ CH₃ D D D D H H D

IV-1116 CH₃ CD₃ CH₃ D D D H D D H

IV-1117 CH₃ CD₃ CH₃ D D D H D H D

IV-1118 CH₃ CD₃ CH₃ D D D H H D D

IV-1119 CH₃ CD₃ CH₃ D D D D D D H

IV- 1120 CH₃ CD₃ CH₃ D D D D D H D

IV-1121 CH₃ CD₃ CH₃ D D D D H D D

IV- 1122 CH₃ CD₃ CH₃ D D D H D D D

IV- 1123 CH₃ CD₃ CH₃ D D D D D D D

IV- 1124 CH₃ CH₃ CD₃ D H H D H H H

IV- 1125 CH₃ CH₃ CD₃ D H H H D H H

IV- 1126 CH₃ CH₃ CD₃ D H H H H D H

IV- 1127 CH₃ CH₃ CD₃ D H H H H H D

IV- 1128 CH₃ CH₃ CD₃ D H H D D H H

IV- 1129 CH₃ CH₃ CD₃ D H H D H D H

IV- 1130 CH₃ CH₃ CD₃ D H H D H H D

IV-1131 CH₃ CH₃ CD₃ D H H H D D H

IV- 1132 CH₃ CH₃ CD₃ D H H H D H D

IV- 1133 CH₃ CH₃ CD₃ D H H H H D D No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9L7R^9B'

IV- 1134 CH₃ CH₃ CD₃ D H H D D D H

IV-1135 CH₃ CH₃ CD₃ D H H D D H D

IV- 1136 c¾ CH₃ CD₃ D H H D H D D

IV- 1137 c¾ CH₃ CD₃ D H H H D D D

IV-1138 c¾ CH₃ CD₃ D H H D D D D

IV- 1139 CH₃ CH₃ CD₃ H D H D H H H

IV- 1140 CH₃ CH₃ CD₃ H D H H D H H

IV-1141 CH₃ CH₃ CD₃ H D H H H D H

IV- 1142 CH₃ CH₃ CD₃ H D H H H H D

IV- 1143 CH₃ CH₃ CD₃ H D H D D H H

IV- 1144 CH₃ CH₃ CD₃ H D H D H D H

IV- 1145 CH₃ CH₃ CD₃ H D H D H H D

IV- 1146 CH₃ CH₃ CD₃ H D H H D D H

IV- 1147 CH₃ CH₃ CD₃ H D H H D H D

IV- 1148 CH₃ CH₃ CD₃ H D H H H D D

IV- 1149 CH₃ CH₃ CD₃ H D H D D D H

IV- 1150 CH₃ CH₃ CD₃ H D H D D H D

IV-1151 CH₃ CH₃ CD₃ H D H D H D D

IV- 1152 CH₃ CH₃ CD₃ H D H H D D D

IV- 1153 CH₃ CH₃ CD₃ H D H D D D D

IV- 1154 CH₃ CH₃ CD₃ H H D D H H H

IV- 1155 CH₃ CH₃ CD₃ H H D H D H H

IV- 1156 CH₃ CH₃ CD₃ H H D H H D H

IV- 1157 CH₃ CH₃ CD₃ H H D H H H D

IV- 1158 CH₃ CH₃ CD₃ H H D D D H H

IV- 1159 CH₃ CH₃ CD₃ H H D D H D H

IV- 1160 CH₃ CH₃ CD₃ H H D D H H D

IV- 1161 CH₃ CH₃ CD₃ H H D H D D H

IV- 1162 CH₃ CH₃ CD₃ H H D H D H D

IV- 1163 CH₃ CH₃ CD₃ H H D H H D D

IV- 1164 CH₃ CH₃ CD₃ H H D D D D H

IV- 1165 CH₃ CH₃ CD₃ H H D D D H D

IV- 1166 CH₃ CH₃ CD₃ H H D D H D D

IV- 1167 CH₃ CH₃ CD₃ H H D H D D D

IV- 1168 CH₃ CH₃ CD₃ H H D D D D D

IV- 1169 CH₃ CH₃ CD₃ D D H D H H H

IV- 1170 CH₃ CH₃ CD₃ D D H H D H H

IV- 1171 CH₃ CH₃ CD₃ D D H H H D H

IV- 1172 CH₃ CH₃ CD₃ D D H H H H D

IV- 1173 CH₃ CH₃ CD₃ D D H D D H H

IV- 1174 CH₃ CH₃ CD₃ D D H D H D H

IV- 1175 CH₃ CH₃ CD₃ D D H D H H D

IV- 1176 CH₃ CH₃ CD₃ D D H H D D H

IV- 1177 CH₃ CH₃ CD₃ D D H H D H D No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9L7R^9B'

IV- 1178 CH₃ CH₃ CD₃ D D H H H D D

IV- 1179 CH₃ CH₃ CD₃ D D H D D D H

IV- 1180 CH₃ CH₃ CD₃ D D H D D H D

IV-1181 CH₃ CH₃ CD₃ D D H D H D D

IV- 1182 CH₃ CH₃ CD₃ D D H H D D D

IV- 1183 CH₃ CH₃ CD₃ D D H D D D D

IV- 1184 CH₃ CH₃ CD₃ D H D D H H H

IV- 1185 CH₃ CH₃ CD₃ D H D H D H H

IV- 1186 CH₃ CH₃ CD₃ D H D H H D H

IV- 1187 CH₃ CH₃ CD₃ D H D H H H D

IV- 1188 CH₃ CH₃ CD₃ D H D D D H H

IV- 1189 CH₃ CH₃ CD₃ D H D D H D H

IV- 1190 CH₃ CH₃ CD₃ D H D D H H D

IV- 1191 CH₃ CH₃ CD₃ D H D H D D H

IV- 1192 CH₃ CH₃ CD₃ D H D H D H D

IV- 1193 CH₃ CH₃ CD₃ D H D H H D D

IV- 1194 CH₃ CH₃ CD₃ D H D D D D H

IV- 1195 CH₃ CH₃ CD₃ D H D D D H D

IV- 1196 CH₃ CH₃ CD₃ D H D D H D D

IV- 1197 CH₃ CH₃ CD₃ D H D H D D D

IV- 1198 CH₃ CH₃ CD₃ D H D D D D D

IV- 1199 CH₃ CH₃ CD₃ H D D D H H H

IV- 1200 CH₃ CH₃ CD₃ H D D H D H H

IV- 1201 CH₃ CH₃ CD₃ H D D H H D H

IV- 1202 CH₃ CH₃ CD₃ H D D H H H D

IV- 1203 CH₃ CH₃ CD₃ H D D D D H H

IV- 1204 CH₃ CH₃ CD₃ H D D D H D H

IV- 1205 CH₃ CH₃ CD₃ H D D D H H D

IV- 1206 CH₃ CH₃ CD₃ H D D H D D H

IV- 1207 CH₃ CH₃ CD₃ H D D H D H D

IV- 1208 CH₃ CH₃ CD₃ H D D H H D D

IV- 1209 CH₃ CH₃ CD₃ H D D D D D H

IV-1210 CH₃ CH₃ CD₃ H D D D D H D

IV-1211 CH₃ CH₃ CD₃ H D D D H D D

IV-1212 CH₃ CH₃ CD₃ H D D H D D D

IV-1213 CH₃ CH₃ CD₃ H D D D D D D

IV-1214 CH₃ CH₃ CD₃ D D D D H H H

IV-1215 CH₃ CH₃ CD₃ D D D H D H H

IV-1216 CH₃ CH₃ CD₃ D D D H H D H

IV-1217 CH₃ CH₃ CD₃ D D D H H H D

IV-1218 CH₃ CH₃ CD₃ D D D D D H H

IV-1219 CH₃ CH₃ CD₃ D D D D H D H

IV- 1220 CH₃ CH₃ CD₃ D D D D H H D

IV- 1221 CH₃ CH₃ CD₃ D D D H D D H No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9L7R^9B'

IV- 1222 CH₃ CH₃ CD₃ D D D H D H D

IV- 1223 CH₃ CH₃ CD₃ D D D H H D D

IV- 1224 c¾ CH₃ CD₃ D D D D D D H

IV- 1225 c¾ CH₃ CD₃ D D D D D H D

IV- 1226 c¾ CH₃ CD₃ D D D D H D D

IV- 1227 c¾ CH₃ CD₃ D D D H D D D

IV- 1228 c¾ CH₃ CD₃ D D D D D D D

IV- 1229 CD₃ CD₃ CH₃ D H H D H H H

IV- 1230 CD₃ CD₃ CH₃ D H H H D H H

IV- 1231 CD₃ CD₃ CH₃ D H H H H D H

IV- 1232 CD₃ CD₃ CH₃ D H H H H H D

IV- 1233 CD₃ CD₃ CH₃ D H H D D H H

IV- 1234 CD₃ CD₃ CH₃ D H H D H D H

IV- 1235 CD₃ CD₃ CH₃ D H H D H H D

IV- 1236 CD₃ CD₃ CH₃ D H H H D D H

IV- 1237 CD₃ CD₃ CH₃ D H H H D H D

IV- 1238 CD₃ CD₃ CH₃ D H H H H D D

IV- 1239 CD₃ CD₃ CH₃ D H H D D D H

IV- 1240 CD₃ CD₃ CH₃ D H H D D H D

IV- 1241 CD₃ CD₃ CH₃ D H H D H D D

IV- 1242 CD₃ CD₃ CH₃ D H H H D D D

IV- 1243 CD₃ CD₃ CH₃ D H H D D D D

IV- 1244 CD₃ CD₃ CH₃ H D H D H H H

IV- 1245 CD₃ CD₃ CH₃ H D H H D H H

IV- 1246 CD₃ CD₃ CH₃ H D H H H D H

IV- 1247 CD₃ CD₃ CH₃ H D H H H H D

IV- 1248 CD₃ CD₃ CH₃ H D H D D H H

IV- 1249 CD₃ CD₃ CH₃ H D H D H D H

IV- 1250 CD₃ CD₃ CH₃ H D H D H H D

IV- 1251 CD₃ CD₃ CH₃ H D H H D D H

IV- 1252 CD₃ CD₃ CH₃ H D H H D H D

IV- 1253 CD₃ CD₃ CH₃ H D H H H D D

IV- 1254 CD₃ CD₃ CH₃ H D H D D D H

IV- 1255 CD₃ CD₃ CH₃ H D H D D H D

IV- 1256 CD₃ CD₃ CH₃ H D H D H D D

IV- 1257 CD₃ CD₃ CH₃ H D H H D D D

IV- 1258 CD₃ CD₃ CH₃ H D H D D D D

IV- 1259 CD₃ CD₃ CH₃ H H D D H H H

IV- 1260 CD₃ CD₃ CH₃ H H D H D H H

IV- 1261 CD₃ CD₃ CH₃ H H D H H D H

IV- 1262 CD₃ CD₃ CH₃ H H D H H H D

IV- 1263 CD₃ CD₃ CH₃ H H D D D H H

IV- 1264 CD₃ CD₃ CH₃ H H D D H D H

IV- 1265 CD₃ CD₃ CH₃ H H D D H H D No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9L7R^9B'

IV- 1266 CD₃ CD₃ CH₃ H H D H D D H

IV- 1267 CD₃ CD₃ CH₃ H H D H D H D

IV- 1268 CD₃ CD₃ CH₃ H H D H H D D

IV- 1269 CD₃ CD₃ CH₃ H H D D D D H

IV- 1270 CD₃ CD₃ CH₃ H H D D D H D

IV- 1271 CD₃ CD₃ CH₃ H H D D H D D

IV- 1272 CD₃ CD₃ CH₃ H H D H D D D

IV- 1273 CD₃ CD₃ CH₃ H H D D D D D

IV- 1274 CD₃ CD₃ CH₃ D D H D H H H

IV- 1275 CD₃ CD₃ CH₃ D D H H D H H

IV- 1276 CD₃ CD₃ CH₃ D D H H H D H

IV- 1277 CD₃ CD₃ CH₃ D D H H H H D

IV- 1278 CD₃ CD₃ CH₃ D D H D D H H

IV- 1279 CD₃ CD₃ CH₃ D D H D H D H

IV- 1280 CD₃ CD₃ CH₃ D D H D H H D

IV- 1281 CD₃ CD₃ CH₃ D D H H D D H

IV- 1282 CD₃ CD₃ CH₃ D D H H D H D

IV- 1283 CD₃ CD₃ CH₃ D D H H H D D

IV- 1284 CD₃ CD₃ CH₃ D D H D D D H

IV- 1285 CD₃ CD₃ CH₃ D D H D D H D

IV- 1286 CD₃ CD₃ CH₃ D D H D H D D

IV- 1287 CD₃ CD₃ CH₃ D D H H D D D

IV- 1288 CD₃ CD₃ CH₃ D D H D D D D

IV- 1289 CD₃ CD₃ CH₃ D H D D H H H

IV- 1290 CD₃ CD₃ CH₃ D H D H D H H

IV- 1291 CD₃ CD₃ CH₃ D H D H H D H

IV- 1292 CD₃ CD₃ CH₃ D H D H H H D

IV- 1293 CD₃ CD₃ CH₃ D H D D D H H

IV- 1294 CD₃ CD₃ CH₃ D H D D H D H

IV- 1295 CD₃ CD₃ CH₃ D H D D H H D

IV- 1296 CD₃ CD₃ CH₃ D H D H D D H

IV- 1297 CD₃ CD₃ CH₃ D H D H D H D

IV- 1298 CD₃ CD₃ CH₃ D H D H H D D

IV- 1299 CD₃ CD₃ CH₃ D H D D D D H

IV- 1300 CD₃ CD₃ CH₃ D H D D D H D

IV- 1301 CD₃ CD₃ CH₃ D H D D H D D

IV- 1302 CD₃ CD₃ CH₃ D H D H D D D

IV- 1303 CD₃ CD₃ CH₃ D H D D D D D

IV- 1304 CD₃ CD₃ CH₃ H D D D H H H

IV- 1305 CD₃ CD₃ CH₃ H D D H D H H

IV- 1306 CD₃ CD₃ CH₃ H D D H H D H

IV- 1307 CD₃ CD₃ CH₃ H D D H H H D

IV- 1308 CD₃ CD₃ CH₃ H D D D D H H

IV- 1309 CD₃ CD₃ CH₃ H D D D H D H No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9L7R^9B'

IV-1310 CD₃ CD₃ CH₃ H D D D H H D

IV-1311 CD₃ CD₃ CH₃ H D D H D D H

IV-1312 CD₃ CD₃ CH₃ H D D H D H D

IV-1313 CD₃ CD₃ CH₃ H D D H H D D

IV-1314 CD₃ CD₃ CH₃ H D D D D D H

IV-1315 CD₃ CD₃ CH₃ H D D D D H D

IV-1316 CD₃ CD₃ CH₃ H D D D H D D

IV-1317 CD₃ CD₃ CH₃ H D D H D D D

IV-1318 CD₃ CD₃ CH₃ H D D D D D D

IV-1319 CD₃ CD₃ CH₃ D D D D H H H

IV- 1320 CD₃ CD₃ CH₃ D D D H D H H

IV- 1321 CD₃ CD₃ CH₃ D D D H H D H

IV- 1322 CD₃ CD₃ CH₃ D D D H H H D

IV- 1323 CD₃ CD₃ CH₃ D D D D D H H

IV- 1324 CD₃ CD₃ CH₃ D D D D H D H

IV- 1325 CD₃ CD₃ CH₃ D D D D H H D

IV- 1326 CD₃ CD₃ CH₃ D D D H D D H

IV- 1327 CD₃ CD₃ CH₃ D D D H D H D

IV- 1328 CD₃ CD₃ CH₃ D D D H H D D

IV- 1329 CD₃ CD₃ CH₃ D D D D D D H

IV- 1330 CD₃ CD₃ CH₃ D D D D D H D

IV- 1331 CD₃ CD₃ CH₃ D D D D H D D

IV- 1332 CD₃ CD₃ CH₃ D D D H D D D

IV- 1333 CD₃ CD₃ CH₃ D D D D D D D

IV- 1334 CD₃ CH₃ CD₃ D H H D H H H

IV-1335 CD₃ CH₃ CD₃ D H H H D H H

IV- 1336 CD₃ CH₃ CD₃ D H H H H D H

IV- 1337 CD₃ CH₃ CD₃ D H H H H H D

IV-1338 CD₃ CH₃ CD₃ D H H D D H H

IV- 1339 CD₃ CH₃ CD₃ D H H D H D H

IV- 1340 CD₃ CH₃ CD₃ D H H D H H D

IV- 1341 CD₃ CH₃ CD₃ D H H H D D H

IV- 1342 CD₃ CH₃ CD₃ D H H H D H D

IV- 1343 CD₃ CH₃ CD₃ D H H H H D D

IV- 1344 CD₃ CH₃ CD₃ D H H D D D H

IV- 1345 CD₃ CH₃ CD₃ D H H D D H D

IV- 1346 CD₃ CH₃ CD₃ D H H D H D D

IV- 1347 CD₃ CH₃ CD₃ D H H H D D D

IV- 1348 CD₃ CH₃ CD₃ D H H D D D D

IV- 1349 CD₃ CH₃ CD₃ H D H D H H H

IV- 1350 CD₃ CH₃ CD₃ H D H H D H H

IV-1351 CD₃ CH₃ CD₃ H D H H H D H

IV- 1352 CD₃ CH₃ CD₃ H D H H H H D

IV- 1353 CD₃ CH₃ CD₃ H D H D D H H No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9L7R^9B'

IV- 1354 CD₃ CH₃ CD₃ H D H D H D H

IV-1355 CD₃ CH₃ CD₃ H D H D H H D

IV- 1356 CD₃ CH₃ CD₃ H D H H D D H

IV- 1357 CD₃ CH₃ CD₃ H D H H D H D

IV-1358 CD₃ CH₃ CD₃ H D H H H D D

IV- 1359 CD₃ CH₃ CD₃ H D H D D D H

IV- 1360 CD₃ CH₃ CD₃ H D H D D H D

IV- 1361 CD₃ CH₃ CD₃ H D H D H D D

IV- 1362 CD₃ CH₃ CD₃ H D H H D D D

IV- 1363 CD₃ CH₃ CD₃ H D H D D D D

IV- 1364 CD₃ CH₃ CD₃ H H D D H H H

IV- 1365 CD₃ CH₃ CD₃ H H D H D H H

IV- 1366 CD₃ CH₃ CD₃ H H D H H D H

IV- 1367 CD₃ CH₃ CD₃ H H D H H H D

IV- 1368 CD₃ CH₃ CD₃ H H D D D H H

IV- 1369 CD₃ CH₃ CD₃ H H D D H D H

IV- 1370 CD₃ CH₃ CD₃ H H D D H H D

IV- 1371 CD₃ CH₃ CD₃ H H D H D D H

IV- 1372 CD₃ CH₃ CD₃ H H D H D H D

IV- 1373 CD₃ CH₃ CD₃ H H D H H D D

IV- 1374 CD₃ CH₃ CD₃ H H D D D D H

IV- 1375 CD₃ CH₃ CD₃ H H D D D H D

IV- 1376 CD₃ CH₃ CD₃ H H D D H D D

IV- 1377 CD₃ CH₃ CD₃ H H D H D D D

IV- 1378 CD₃ CH₃ CD₃ H H D D D D D

IV- 1379 CD₃ CH₃ CD₃ D D H D H H H

IV- 1380 CD₃ CH₃ CD₃ D D H H D H H

IV-1381 CD₃ CH₃ CD₃ D D H H H D H

IV- 1382 CD₃ CH₃ CD₃ D D H H H H D

IV- 1383 CD₃ CH₃ CD₃ D D H D D H H

IV- 1384 CD₃ CH₃ CD₃ D D H D H D H

IV- 1385 CD₃ CH₃ CD₃ D D H D H H D

IV- 1386 CD₃ CH₃ CD₃ D D H H D D H

IV- 1387 CD₃ CH₃ CD₃ D D H H D H D

IV- 1388 CD₃ CH₃ CD₃ D D H H H D D

IV- 1389 CD₃ CH₃ CD₃ D D H D D D H

IV- 1390 CD₃ CH₃ CD₃ D D H D D H D

IV- 1391 CD₃ CH₃ CD₃ D D H D H D D

IV- 1392 CD₃ CH₃ CD₃ D D H H D D D

IV- 1393 CD₃ CH₃ CD₃ D D H D D D D

IV- 1394 CD₃ CH₃ CD₃ D H D D H H H

IV- 1395 CD₃ CH₃ CD₃ D H D H D H H

IV- 1396 CD₃ CH₃ CD₃ D H D H H D H

IV- 1397 CD₃ CH₃ CD₃ D H D H H H D No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9L7R^9B'

IV- 1398 CD₃ CH₃ CD₃ D H D D D H H

IV- 1399 CD₃ CH₃ CD₃ D H D D H D H

IV- 1400 CD₃ CH₃ CD₃ D H D D H H D

IV- 1401 CD₃ CH₃ CD₃ D H D H D D H

IV- 1402 CD₃ CH₃ CD₃ D H D H D H D

IV- 1403 CD₃ CH₃ CD₃ D H D H H D D

IV- 1404 CD₃ CH₃ CD₃ D H D D D D H

IV- 1405 CD₃ CH₃ CD₃ D H D D D H D

IV- 1406 CD₃ CH₃ CD₃ D H D D H D D

IV- 1407 CD₃ CH₃ CD₃ D H D H D D D

IV- 1408 CD₃ CH₃ CD₃ D H D D D D D

IV- 1409 CD₃ CH₃ CD₃ H D D D H H H

IV-1410 CD₃ CH₃ CD₃ H D D H D H H

IV-1411 CD₃ CH₃ CD₃ H D D H H D H

IV-1412 CD₃ CH₃ CD₃ H D D H H H D

IV-1413 CD₃ CH₃ CD₃ H D D D D H H

IV-1414 CD₃ CH₃ CD₃ H D D D H D H

IV-1415 CD₃ CH₃ CD₃ H D D D H H D

IV-1416 CD₃ CH₃ CD₃ H D D H D D H

IV-1417 CD₃ CH₃ CD₃ H D D H D H D

IV-1418 CD₃ CH₃ CD₃ H D D H H D D

IV-1419 CD₃ CH₃ CD₃ H D D D D D H

IV- 1420 CD₃ CH₃ CD₃ H D D D D H D

IV- 1421 CD₃ CH₃ CD₃ H D D D H D D

IV- 1422 CD₃ CH₃ CD₃ H D D H D D D

IV- 1423 CD₃ CH₃ CD₃ H D D D D D D

IV- 1424 CD₃ CH₃ CD₃ D D D D H H H

IV- 1425 CD₃ CH₃ CD₃ D D D H D H H

IV- 1426 CD₃ CH₃ CD₃ D D D H H D H

IV- 1427 CD₃ CH₃ CD₃ D D D H H H D

IV- 1428 CD₃ CH₃ CD₃ D D D D D H H

IV- 1429 CD₃ CH₃ CD₃ D D D D H D H

IV- 1430 CD₃ CH₃ CD₃ D D D D H H D

IV- 1431 CD₃ CH₃ CD₃ D D D H D D H

IV- 1432 CD₃ CH₃ CD₃ D D D H D H D

IV- 1433 CD₃ CH₃ CD₃ D D D H H D D

IV- 1434 CD₃ CH₃ CD₃ D D D D D D H

IV- 1435 CD₃ CH₃ CD₃ D D D D D H D

IV- 1436 CD₃ CH₃ CD₃ D D D D H D D

IV- 1437 CD₃ CH₃ CD₃ D D D H D D D

IV- 1438 CD₃ CH₃ CD₃ D D D D D D D

IV- 1439 CH₃ CD₃ CD₃ D H H D H H H

IV- 1440 CH₃ CD₃ CD₃ D H H H D H H

IV- 1441 CH₃ CD₃ CD₃ D H H H H D H No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9L7R^9B'

IV- 1442 CH₃ CD₃ CD₃ D H H H H H D

IV- 1443 CH₃ CD₃ CD₃ D H H D D H H

IV- 1444 c¾ CD₃ CD₃ D H H D H D H

IV- 1445 c¾ CD₃ CD₃ D H H D H H D

IV- 1446 c¾ CD₃ CD₃ D H H H D D H

IV- 1447 c¾ CD₃ CD₃ D H H H D H D

IV- 1448 c¾ CD₃ CD₃ D H H H H D D

IV- 1449 c¾ CD₃ CD₃ D H H D D D H

IV- 1450 c¾ CD₃ CD₃ D H H D D H D

IV- 1451 c¾ CD₃ CD₃ D H H D H D D

IV- 1452 CH₃ CD₃ CD₃ D H H H D D D

IV- 1453 CH₃ CD₃ CD₃ D H H D D D D

IV- 1454 CH₃ CD₃ CD₃ H D H D H H H

IV- 1455 CH₃ CD₃ CD₃ H D H H D H H

IV- 1456 CH₃ CD₃ CD₃ H D H H H D H

IV- 1457 CH₃ CD₃ CD₃ H D H H H H D

IV- 1458 CH₃ CD₃ CD₃ H D H D D H H

IV- 1459 CH₃ CD₃ CD₃ H D H D H D H

IV- 1460 CH₃ CD₃ CD₃ H D H D H H D

IV- 1461 CH₃ CD₃ CD₃ H D H H D D H

IV- 1462 CH₃ CD₃ CD₃ H D H H D H D

IV- 1463 CH₃ CD₃ CD₃ H D H H H D D

IV- 1464 CH₃ CD₃ CD₃ H D H D D D H

IV- 1465 CH₃ CD₃ CD₃ H D H D D H D

IV- 1466 CH₃ CD₃ CD₃ H D H D H D D

IV- 1467 CH₃ CD₃ CD₃ H D H H D D D

IV- 1468 CH₃ CD₃ CD₃ H D H D D D D

IV- 1469 CH₃ CD₃ CD₃ H H D D H H H

IV- 1470 CH₃ CD₃ CD₃ H H D H D H H

IV- 1471 CH₃ CD₃ CD₃ H H D H H D H

IV- 1472 CH₃ CD₃ CD₃ H H D H H H D

IV- 1473 CH₃ CD₃ CD₃ H H D D D H H

IV- 1474 CH₃ CD₃ CD₃ H H D D H D H

IV- 1475 CH₃ CD₃ CD₃ H H D D H H D

IV- 1476 CH₃ CD₃ CD₃ H H D H D D H

IV- 1477 CH₃ CD₃ CD₃ H H D H D H D

IV- 1478 CH₃ CD₃ CD₃ H H D H H D D

IV- 1479 CH₃ CD₃ CD₃ H H D D D D H

IV- 1480 CH₃ CD₃ CD₃ H H D D D H D

IV- 1481 CH₃ CD₃ CD₃ H H D D H D D

IV- 1482 CH₃ CD₃ CD₃ H H D H D D D

IV- 1483 CH₃ CD₃ CD₃ H H D D D D D

IV- 1484 CH₃ CD₃ CD₃ D D H D H H H

IV- 1485 CH₃ CD₃ CD₃ D D H H D H H No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9l7R^9b'

IV- 1486 CH₃ CD₃ CD₃ D D H H H D H

IV- 1487 CH₃ CD₃ CD₃ D D H H H H D

IV- 1488 CH₃ CD₃ CD₃ D D H D D H H

IV- 1489 CH₃ CD₃ CD₃ D D H D H D H

IV- 1490 CH₃ CD₃ CD₃ D D H D H H D

IV- 1491 CH₃ CD₃ CD₃ D D H H D D H

IV- 1492 CH₃ CD₃ CD₃ D D H H D H D

IV- 1493 CH₃ CD₃ CD₃ D D H H H D D

IV- 1494 CH₃ CD₃ CD₃ D D H D D D H

IV- 1495 CH₃ CD₃ CD₃ D D H D D H D

IV- 1496 CH₃ CD₃ CD₃ D D H D H D D

IV- 1497 CH₃ CD₃ CD₃ D D H H D D D

IV- 1498 CH₃ CD₃ CD₃ D D H D D D D

IV- 1499 CH₃ CD₃ CD₃ D H D D H H H

IV- 1500 CH₃ CD₃ CD₃ D H D H D H H

IV- 1501 CH₃ CD₃ CD₃ D H D H H D H

IV- 1502 CH₃ CD₃ CD₃ D H D H H H D

IV- 1503 CH₃ CD₃ CD₃ D H D D D H H

IV- 1504 CH₃ CD₃ CD₃ D H D D H D H

IV- 1505 CH₃ CD₃ CD₃ D H D D H H D

IV- 1506 CH₃ CD₃ CD₃ D H D H D D H

IV- 1507 CH₃ CD₃ CD₃ D H D H D H D

IV- 1508 CH₃ CD₃ CD₃ D H D H H D D

IV- 1509 CH₃ CD₃ CD₃ D H D D D D H

IV-1510 CH₃ CD₃ CD₃ D H D D D H D

IV-1511 CH₃ CD₃ CD₃ D H D D H D D

IV-1512 CH₃ CD₃ CD₃ D H D H D D D

IV-1513 CH₃ CD₃ CD₃ D H D D D D D

IV-1514 CH₃ CD₃ CD₃ H D D D H H H

IV-1515 CH₃ CD₃ CD₃ H D D H D H H

IV-1516 CH₃ CD₃ CD₃ H D D H H D H

IV-1517 CH₃ CD₃ CD₃ H D D H H H D

IV-1518 CH₃ CD₃ CD₃ H D D D D H H

IV-1519 CH₃ CD₃ CD₃ H D D D H D H

IV- 1520 CH₃ CD₃ CD₃ H D D D H H D

IV- 1521 CH₃ CD₃ CD₃ H D D H D D H

IV- 1522 CH₃ CD₃ CD₃ H D D H D H D

IV- 1523 CH₃ CD₃ CD₃ H D D H H D D

IV- 1524 CH₃ CD₃ CD₃ H D D D D D H

IV- 1525 CH₃ CD₃ CD₃ H D D D D H D

IV- 1526 CH₃ CD₃ CD₃ H D D D H D D

IV- 1527 CH₃ CD₃ CD₃ H D D H D D D

IV- 1528 CH₃ CD₃ CD₃ H D D D D D D

IV- 1529 CH₃ CD₃ CD₃ D D D D H H H No. R R R^J R /R /R RVR⁶ R⁷/R⁷ R*7R*^a R^m/R^m' R^YA/R^YA' R^9L7R^9B'

IV- 1530 CH₃ CD₃ CD₃ D D D H D H H

IV- 1531 CH₃ CD₃ CD₃ D D D H H D H

IV- 1532 c¾ CD₃ CD₃ D D D H H H D

IV- 1533 CH₃ CD₃ CD₃ D D D D D H H

IV- 1534 CH₃ CD₃ CD₃ D D D D H D H

IV- 1535 CH₃ CD₃ CD₃ D D D D H H D

IV- 1536 CH₃ CD₃ CD₃ D D D H D D H

IV- 1537 CH₃ CD₃ CD₃ D D D H D H D

IV- 1538 CH₃ CD₃ CD₃ D D D H H D D

IV- 1539 CH₃ CD₃ CD₃ D D D D D D H

IV- 1540 CH₃ CD₃ CD₃ D D D D D H D

IV- 1541 CH₃ CD₃ CD₃ D D D D H D D

IV- 1542 CH₃ CD₃ CD₃ D D D H D D D

IV- 1543 CH₃ CD₃ CD₃ D D D D D D D

[0044] In some embodiments of Formula I, each of R⁵, R^9a, R^9a', R⁹ , R^{9 '}, R^xa, R^x , R^{x '}, R^xc, R^ya, R^ya', R^y and R^{y '} is hydrogen. Accordingly, in some embodiments, the present invention provides a compound of Formula V:

V

or a pharmaceutically acceptable salt thereof, wherein:

_R1 a

1 b

^■ R

R 1 c

each of R^la, R^l , R^lc, R^2a, R², R^2c, R^3a, R³, R^3c, R⁴, R^4', R^4", R⁶, R^6', R⁷, R^7', R^8a, R^8a', R⁸, and R^{8 '} is as defined herein, provided that at least one of R^la, R^l, R^lc, R^2a, R², R^2c, R^3a, R³, R^3c, R⁴, R^4', R^4", R⁶, R^6', R⁷, R^7', R^8a, R^8a', R⁸, and R^{8 '} is deuterium.

[0045] In some embodiments of Formula I, each of R⁵, R^8a, R^8a', R⁸, R^{8 '}, R^9a, R^9a', R⁹, R^{9 '}, R^xa, R^x, R^{x '}, R^xc, R^ya, R^ya', R^y and R^{y '} is hydrogen. Accordingly, in some embodiments, the present invention provides a compound of Formula VI:

VI

or a harmaceutically acceptable salt thereof, wherein:

each of R^la, R^l , R^lc, R^2a, R² , R^2c, R^3a, R³ , R^3c, R⁴, R^4', R^4", R⁶, R^6', R⁷, and R^7' is as defined herein, provided that at least one of R^la, R^l , R^lc, R^2a, R² , R^2c, R^3a, R³ , R^3c, R⁴, R^4', R^4", R⁶, R⁶ , R⁷, and R⁷ is deuterium.

Uses of Compounds and Pharmaceutically Acceptable Compositions

[0046] Compounds and compositions described herein are generally useful for the inhibition of protein kinase activity of one or more enzymes.

[0047] The compounds of the invention may be formulated into therapeutic compositions as natural or sail forms. Pharmaceutically accepiabie non-toxic salts include the base addition salts (formed with free carboxyl or other anionic groups) which may be derived from inorganic bases such as, for example, sodium, potassium, ammonium, calcium, or ferric hydroxides, and such organic bases as isopropyiamine, trimethylamine, 2-ethyiamino-ethanoi, histidine, procaine, and the like. Such salts may also be formed as acid addition salts with any free cationic groups and will generally be formed with inorganic acids such as, for example, hydrochloric, sulfuric, or phosphoric acids, or organic acids such as acetic, citric, p-toluenesulfonic, methanesulfonic acid, oxalic, tartaric, mandelie, and the like.

[0048] Salts of the invention can include amine salts formed by the protonation of an amino group with inorganic acids such as hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, phosphoric acid, and the like. Salts of the invention can also include amine salts formed by the protonation of an ammo group with suitable organic acids, such as p- toluenesulfonic acid, acetic acid, methanesulfonic acid and the like. Additional excipients which are contemplated for use in the practice of the present invention are those available to those of ordinary skill in the art, for example, those found in the United States Pharmacopeia Vol. XXII and National Formulary Vol. XVII, U. S. Pharmacopeia Convention, Inc., Rockville, Md. (1989), the relevant contents of which is incorporated herein by reference. In addition, polymorphs of the invention compounds are included in the present invention.

[0049] In some embodiments, a compound of Formula I is in the form of a hydrochloride salt. In some such embodiments, a compound of Formula I is in the form of a di hydrochloride salt. In some embodiments, a compound of Formula I is in the form of a dihydrochloride monohydrate. [0050] Protein kinases are families of enzymes that catalyze the phosphorylation of specific residues in proteins, broadly classified into tyrosine and serine/threonine kinases. Inappropriate kinase activity, arising from mutation, over-expression, or inappropriate regulation, dys- regulation or de-regulation, as well as over- or under-production of growth factors or cytokines has been implicated in many diseases, including but not limited too cancer, cardiovascular diseases, allergies, asthma and other respiratory diseases, autoimmune diseases, inflammatory diseases, bone diseases, metabolic disorders, and neurological and neurodegenerative disorders such as Alzheimer's disease. Inappropriate kinase activity triggers a variety of biological cellular responses relating to cell growth, cell differentiation, survival, apoptosis, mitogenesis, cell cycle control, and cell mobility implicated in the aforementioned and related diseases.

[0051] Protein kinases have emerged as an important class of enzymes as targets for therapeutic intervention. In particular, the JAK family of cellular protein tyrosine kinases (Jakl, Jak2, Jak3, and Tyk2) play a central role in cytokine signaling (Kisseleva et al, Gene, 2002, 285, 1 ; Yamaoka et al. Genome Biology 2004, 5, 253)). Upon binding to their receptors, cytokines activate JAK which then phosphorylate the cytokine receptor, thereby creating docking sites for signaling molecules, notably, members of the signal transducer and activator of transcription (STAT) family that ultimately lead to gene expression. Numerous cytokines are known to activate the JAK family, including IFN family cytokines (IFN-as/p/ro/Limitin, IFN-γ, IL-10, IL- 19, IL-20, IL-22), gpl 30 family cytokines (IL-6, IL-11 , OSM, LIF, CNTF, NNT-l/BSF-3, G- CSF, CT-1 , Leptin, IL-12, IL-23), jC family cytokines (IL-2, IL-7, TSLP, IL-9, IL-15, IL-21, IL-4, IL-13), IL-3 family cytokines (IL-3, IL-5, GM-CSF), single chain family cytokines (EPO, GH, PRL, TPO), receptor tyrosine kinases (EGF, PDGF, CSF-1, HGF), and G-protein coupled receptors (ATI).

[0052] Until recently, the therapeutic potential of JAK inhibitors has focused on diseases affecting various pathologies of the immune system, including, but not limited to, atopy (allergic asthma, atopic dermatitis, allergic rhinitis), cell mediated hypersensitivity (allergic contact dermatitis, hypersensitivity pneumonitis), rheumatic diseases (systemic lupus erythematosus (SLE), rheumatoid arthritis, juvenile arthritis, Sjogren's Syndrome, scleroderma, polymyositis, ankylosing spondylitis, psoriatic arthritis), transplantation (transplant rejection, graft vs host disease), viral diseases (Epstein Barr Virus, Hepatitis B, Hepatitis C, HIV, HTLV1, Vaicella- Zoster Virus, Human Papilloma Virus), cancer (leukemia, lymphoma), cardiovascular disease (cardiac hypertrophy, atherosclerosis and arteriosclerosis), neurodegenerative diseases (motor neuron disease), food allergy, inflammatory bowel disease, Crohn's disease, cutaneous inflammation, and immune suppression induced by solid tumors. Most efforts to date have targeted JAK3 inhibition for immunosuppression, for example organ transplantation and allograft acceptance (for a review, see Borie et al. Current Opinion in Investigational Drugs, 2003, 4(11), 1297).

[0053] Most recently, two significant findings of the role of the EPO-JAK2 signaling pathway in myeloproliferative disorders and proliferative diabetic retinopathy were found. First, a gain-of-function, somatic (acquired) mutation of the JAK2 kinase (V617F) was reported to be a causative factor in a number of "typical" myeloproliferative disorders, including polycythemia vera, essential thrombocythemia and myelofibrosis with myeloid metaplasia, and the mutation has been found in patients with either "atypical" myeloproliferative disorders and myelodysplastic syndrome (for reviews see Tefferi and Gilliland, Cell Cycle 2005, 4(8), e61; Pesu et. al. Molecular Interventions 2005, 5(4), 211). Additionally it was found that (a) the V617F JAK2 mutation was associated with constitutive phosphorylation of JAK2 and its downstream effectors as well as induction of erythropoietin hypersensitivity in cell based experiments, (b) V617F JAK2-induced cell proliferation signals were inhibited by small molecule inhibitors of JAK2, and (c) murine bone marrow transduced with a retrovirus containing V617F JAK2 included erythrocytosis in the transplanted mice.

[0054] Furthermore, it has been found that mutations in EPO-R also keep the JAK pathway constitutively activated leading to myeloproliferative disorders.

[0055] It has also been demonstrated that the JAK pathway may be recruited in cell survival and proliferation. For example, in the case of the cells that are Philadelphia chromosome positive that result in chronic myelogenous leukemia (CML), there is evidence that the Jak pathway is recruited in constitutive activation. Accordingly, using a JAK inhibitor may have use in CML in which the Philadelphia chromosome has been shown to produce the hybrid Bcr-Abl, thus keeping cells constitutively active.

[0001] In cases of resistance mutations that arise on account of specific inhibitors to BCR- ABL, as in the case of the T3151 gatekeeper mutation, or any other mutation, it may be possible to use a JAK inhibitor due to the fact that the BCR-ABL mutant (e.g., BCR-ABL(T315I)) utilizes the Jak pathway. Thus Jak inhibitors may be useful in the treatment of patients with resistance to known therapies where BCR-ABL is directly targeted and drug resistance has now been shown as the dominant (50-90%) of all resistance in patients where existing therapies fail. Without wishing to be bound by any particular theory, it is believed that compounds of the present invention may be effective inhibitors of drug resistant forms of protein kinases.

[0002] As used herein, the term "resistance" refers to changes in the wild-type nucleic acid sequence coding a target protein, and/or the protein sequence of the target, which changes decrease or abolish the inhibitory effect of the inhibitor on the target protein.

[0056] The activity of a compound utilized in this invention as an inhibitor of JAK2, or a mutant thereof, may be assayed in vitro, in vivo or in a cell line. In vitro assays include assays that determine inhibition of either the phosphorylation activity and/or the subsequent functional consequences, or ATPase activity of activated JAK2, or a mutant thereof. Alternate in vitro assays quantitate the ability of the inhibitor to bind to JAK2. Inhibitor binding may be measured by radiolabeling the inhibitor prior to binding, isolating the inhibitor/JAK2 complex and determining the amount of radiolabel bound. Alternatively, inhibitor binding may be determined by running a competition experiment where new inhibitors are incubated with JAK2 bound to known radioligands.

[0057] According to another embodiment, the invention provides a method for treating or lessening the severity of a JAK2-mediated disease or condition in a patient comprising the step of administering to said patient a composition according to the present invention.

[0058] The term "JAK2-mediated disease", as used herein means any disease or other deleterious condition in which a JAK2 kinase is known to play a role. Accordingly, another embodiment of the present invention relates to treating or lessening the severity of one or more diseases in which JAK2 is known to play a role.

[0059] The compounds and methods of the present invention, or pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers thereof, are useful in treating a variety of disorders, including, but not limited to for example, proliferative diabetic retinopathy and other angiogenic-associated disorders, eye disease, inflammation such as psoriasis, and a viral infection. The kinds of cancer that can be treated include, but are not limited to, myeloproliferative disorders, polycythemia vera, essential thrombocythemia, myeloid fibrosis with myeloid metaplasia, other myeloid-linked disorders, an alimentary/gastrointestinal tract cancer, colon cancer, liver cancer, skin cancer, breast cancer, ovarian cancer, prostate cancer, multiple myeloma, lymphoma (including Non-Hodgkin's lymphoma and Hodgkin's lymphoma), leukemia (including acute myelogenous leukemia, chronic myelogenous leukemia which may be drug resistant, chronic myelomonocytic leukemia, chronic lymphocytic leukemia, chronic neutrophilic (CNL), eosinophilic (CEL) and myelomonocytic (CMML) leukemias; juvenile myelomonocytic leukemia (JMML)), hypereosinophilic syndrome, myelodysplastic syndromes, including refractory anemia with ringed sideroblasts, kidney cancer, lung cancer, muscle cancer, bone cancer, bladder cancer or brain cancer.

[0060] Some examples of the diseases and disorders thai can be treated also include ocular neovascularization, infantile haemangiomas: organ hypoxia, vascular hyperplasia, organ transplant rejection, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type 1 diabetes and complications from diabetes, inflammatory disease, acute pancreatitis, chronic pancreatitis, asthma, allergies, adult respirator ' distress syndrome, cardiovascular disease, liver disease, other blood disorders, asthma, rhinitis, atopic, dermatitis, autoimmune thyroid disorders, ulcerative colitis. Crohn's disease, metastatic melanoma, Kaposi's sarcoma, multiple myeloma, conditions associated with cytokines, and other autoimmune diseases including glomerulonephritis, scleroderma, chronic thyroiditis. Graves' disease, autoimmune gastritis, autoimmune hemolytic anemia, autoimmune neutropenia, thrombocytopenia, atopy (e.g. allergic asthma, atopic dermatitis, or allergic rhinitis), chronic active hepatitis, myasthenia gravis, multiple sclerosis, inflammatory bowel disease, graft vs host disease, neurodegenerative diseases including motor neuron disease. Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, cerebral ischemia, or neurodegenerative disease caused by traumatic injury, strike, glutama e neurotoxicity or hypoxia; i chenuc/reperfusion injury in stroke, myocardial ischemia, renal ischemia, heart attacks, cardiac hypertrophy, atherosclerosis and arteriosclerosis, organ hypoxia, platelet aggregation, and mastocytosis. In some embodiments, the disease being treated is selected from rheumatoid arthritis, juvenile idiopathic arthritis, psoriasis, systemic scleroderma and Crohn's disease. Examples of some additional diseases and disorders that can be treated also include cell mediated hypersensitivity (allergic contact dermatitis, hypersensitivity pneumonitis), rheumatic diseases (e.g., systemic lupus erythematosus (SEE), juvenile arthritis. Sjogren's Syndrome, scleroderma, polymyositis, ankylosing spondylitis, psoriatic arthritis), viral diseases (Epstein Barr Virus, Hepatitis B, Hepatitis C, HIV, HTLV1 , Vaicel la-Zoster Virus. Human Papilloma Virus), food allergy, cutaneous inflammation, and immune suppression induced by solid tumors.

[0061] One embodiment provides a method for treating a disease selected from systemic sclerosis, rheumatoid arthritis, mastocytosis, chronic myelogenous leukemia, and chronic eosinophilic leukemia comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the invention. In another embodiment, the disease is systemic sclerosis. In another embodiment, the disease is rheumatoid arthritis. In another embodiment, the disease is mastocytosis, such as systemic mastocytosis. In another embodiment, the disease is chronic myelogenous leukemia, such as drug resistant chronic myelogenous leukemia. In another embodiment, the disease is chronic eosinophilic leukemia. A further embodiment provides for the use of a therapeutically effective amount of a compound of the invention in the manufacture of a medicament for treating a disease selected from, systemic sclerosis, rheumatoid arthritis, mastocytosis, chronic myelogenous leukemia, and chronic eosinophilic leukemia in a subject in need thereof.

[0062] In some embodiments, the present invention relates to a method of treating or lessening the severity of a myeloproliferative disease or condition. In some embodiments, the myeloproliferative disease or condition is selected from primary myelofibrosis, secondary myelofibrosis, polycythemia vera, essential thrombocythemia, post polycythemia vera, and post essential thrombocythemia. In some embodiments, said method comprises administering to a patient in need thereof a composition according to the present invention.

[0063] Also provided herein are methods of treating myelofibrosis in a subject, comprising administering to the subject an effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof or a hydrate thereof, wherein the subject has previously received another myelofibrosis therapy. In some embodiments, the previous therapy is a treatment with a JAK2 inhibitor which is not N-tert-butyl-3-[(5-methyl-2-{[4-(2-pyrrolidin-l- ylethoxy)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide or a pharmaceutically acceptable salt thereof or a hydrate thereof. In some embodiments, the previous therapy comprises administration of INCBO 18424 (ruxolitinib). In some embodiments, the subject is unresponsive to the previous therapy. In some embodiments, the previous therapy is a treatment with N-tert-butyl-3-[(5-methyl-2- {[4-(2-pyrrolidin-l -ylethoxy)phenyl]amino}pyrimidin-4- yl)amino]benzenesulfonamide or a pharmaceutically acceptable salt thereof or a hydrate thereof. In some embodiments, the previous therapy has been discontinued upon indication of elevated levels of amylase, lipase, aspartate aminotransferase ("AST"), alanine aminotransferase ("ALT"), and/or creatinine. In some embodiments, the previous therapy has been discontinued upon indication of a hematologic condition selected from the group consisting of anemia, thrombocytopenia, and neutropenia.

[0064] The compounds and compositions, according to the method of the present invention, may be administered using any amount and any route of administration effective for treating or lessening the severity of the condition being treated. The exact amount required will vary from subject to subject, depending on the species, age, and general condition of the subject, the severity of the infection, the particular agent, its mode of administration, and the like. Compounds of the invention are preferably formulated in dosage unit form for ease of administration and uniformity of dosage. The expression "dosage unit form" as used herein refers to a physically discrete unit of agent appropriate for the patient to be treated. It will be understood, however, that the total daily usage of the compounds and compositions of the present invention will be decided by the attending physician within the scope of sound medical judgment. The specific effective dose level for any particular patient or organism will depend upon a variety of factors including the disorder being treated and the severity of the disorder; the activity of the specific compound employed; the specific composition employed; the age, body weight, general health, sex and diet of the patient; the time of administration, route of administration, and rate of excretion of the specific compound employed; the duration of the treatment; drugs used in combination or coincidental with the specific compound employed, and like factors well known in the medical arts. The term "patient", as used herein, means an animal, preferably a mammal, and most preferably a human.

[0065] The pharmaceutical compositions for the administration of the compounds described herein may conveniently be presented in dosage unit form and may be prepared by any of the methods well known m the art of pharmacy. All methods include bringing the active ingredient into association with the carrier which constitutes one or more accessory ingredients. In general, the pharmaceutical compositions are prepared by uniformly and intimately bringing the active ingredient into association with a liquid carrier or a finely divided solid earner or both, and then, if necessary, shaping the product into the desired formulation. In the pharmaceutical composition the active object compound is included in an amount sufficient to produce the desired effect upon the process or condition of diseases. The pharmaceutical compositions containing the active ingredient may be in a form suitable for oral use, for example, as tablets, troches, lozenges, aqueous or oily suspensions, dispersihle powders or granules, emulsions, hard or soft capsules, or syrups or elixirs.

[0066] Compositions intended for oral use may be prepared according to any method known to the art for the manufacture of pharmaceutical compositions and such compositions may contain one or more agents selected from the group consisting of sweetening agents, flavoring agents, coloring agents and preserving agents in order to provide pharmaceutically elegant and palatable preparations. Tablets contain the active ingredient in admixture with non-toxic pharmaceutically acceptable excipients which are suitable for the manufacture of tablets. These excipients may be for example, inert diluents, such as calcium carbonate, sodium carbonate, lactose, calcium phosphate or sodium phosphate; granulating and disintegrating agents, for example, corn starch, or alginic acid; binding agents, for example starch, gelatin or acacia, and lubricating agents, for example magnesium stearate, stearic acid or talc. The tablets may be uncoated or they may be coated by known techniques to delay disintegration and absorption in the gastrointestinal tract and thereby provide a sustained action over a longer period. For example, a time delay material such as glyceryl monostearate or glyceryl distearate may be employed. They may also be coated to form, osmotic therapeutic tablets for control release.

[0067] Formulations for oral use may also be presented as hard gelatin capsules wherein the active ingredient is mixed with an inert solid diluent, for example, calcium carbonate, calcium phosphate or kaolin, or as soft gelatin capsules wherein the active ingredient is mixed with water or an oil medium, for example peanut oil, liquid paraffin, or olive oil.

[0068] Gelatin capsules, in addition to the active ingredient, may comprise rmcrocrystallme cellulose, for example, silicified mierocrystaliine cellulose, and a Iubncant such as, for example, magnesium stearate or sodium stearyl fumarate.

[0069] Aqueous suspensions contain the active materials in admixture with excipients suitable for the manufacture of aqueous suspensions. Such excipients are suspending agents, for example sodium carboxymethylcellulose, methylcellulose, hydroxy-propylmethylcellulose, sodium alginate, polyvinyl-pyrrolidone, gum tragacanth and gum acacia; dispersing or wetting agents may be a naturally-occurring phosphatide, for example lecithin, or condensation products of an alkylene oxide with fatty acids, for example polyoxyethylene stearate, or condensation products of ethylene oxide with long chain aliphatic alcohols, for example heptadecaeth leneoxy cetanol or condensation products of ethylene oxide with partial esters derived from fatty acids and a hexitol such as poiyoxyethylene sorbitol monooleate, or condensation products of ethylene oxide with partial esters derived from fatty acids and hexitoi anhydrides, for example polyethylene sorbitan monooleate. Also useful as a soluhilizer is polyethylene glycol, for example. The aqueous suspensions may also contain one or more preservatives, for example ethyl, or n propy , p-hydroxybenzoate, one or more coloring agents, one or more flavoring agents, and one or more sweetening agents, such as sucrose or saccharin.

[0070] Oily suspensions may be formulated by suspending the active ingredient in a vegetable oil, for example arachis oil, olive oil, sesame oil or coconut oil, or in a mineral oil such as liquid paraffin. The oily suspensions may contain a thickening agent, for example beeswax, hard paraffin or cetyl alcohol. Sweetening agents such as those set forth above, and flavoring agents may be added to provide a palatable oral preparation. These compositions may be preserved by the addition of an antioxidant such as ascorbic acid,

[0071] Dispersible powders and granules suitable for preparation of an aqueous suspension by the addition of water provide the active ingredient in admixture with a dispersing or wetting agent, suspending agent and one or more preservatives. Suitable dispersing or wetting agents and suspending agents are exemplified by those already mentioned above. Additional exeipients, for example sweetening, flavoring and coloring agents, may also be present,

[0072] Syrups and elixirs may be formulated with sweetening agents, for example glycerol, propylene glycol, sorbitol or sucrose. Such formulations may also contain a demulcent, a preservative and flavoring and coloring agents,

[0073] The pharmaceutical compositions may be in the form of a sterile injectable aqueous or oleagenoiis suspension. This suspension may be formulated according to the known art using those suitable dispersing or wetting agents and suspending agents which have been mentioned above. The sterile injectable preparation may also be a sterile injectable solution or suspension in a parenterally-aeceptable diluent or solvent or cosolvent or complexing agent or dispersing agent or excipient or combination thereof, for example 1,3-butanediol, polyethylene glycols, polypropylene glycols, ethanol or other alcohols, povidones, various brands of TWEEN surfactant, sodium dodecyl sulfate, sodium deoxycholate, dimethylacetamide, polysorbates, poloxamers, cyclodextrins, lipids, and exeipients such as inorganic salts (e.g., sodium chloride), buffering agents (e.g., sodium citrate, sodium phosphate), and sugars (e.g., saccharose and dextrose). Among the acceptable vehicles and solvents that may be employed are water, dextrose solutions. Ringer's solutions and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil may be employed including synthetic mono- or digiycerides. In addition, fatty acids such as oleic acid find use in the preparation of imectables.

[0074] Depending on the condition being treated, these pharmaceutical compositions may be formulated and administered systemicaily or locally. Techniques for formulation and administration may be found in the latest edition of "'Remington's Pharmaceutical Sciences" (Mack Publishing Co, Easton Pa. ). Suitable routes may, for example, include oral or transmucosal administration; as well as parenteral delivery, including intramuscular, subcutaneous, intramedullary, intrathecal, intraventricular, intravenous, intraperitoneal, or intranasal administration. For injection, the pharmaceutical compositions of the invention may be formulated in aqueous solutions, preferably in physiologically compatible buffers such as Hanks' solution, Ringer's solution, or physiologically buffered saline. For tissue or cellular administration, penetrants appropriate to the particular barrier to be permeated are used in the formulation. Such penetrants are generally known in the art. Pharmaceutical formulations for parenteral administration include aqueous solutions of the active compounds in water-soluble form. Additionally, suspensions of the active compounds may be prepared as appropriate oily injection suspensions. Suitable lipophilic solvents or vehicles include fatty oils such as sesame oil, or synthetic fatty acid esters, such as ethyl oleate or triglycerides, or liposomes. Aqueous injection suspensions may contain substances that increase the viscosity of the suspension, such as sodium carboxyrnethyl cellulose, sorbitol, or dextran. Optionally, the suspension may also contain suitable stabilizers or agents that increase the solubility of the compounds to allow for the preparation of highly concentrated solutions.

[0075] The corn pounds of the present invention may also be administered in the form of suppositories for rectal administration of the drug. These compositions can be prepared by mixing the drug with a suitable non-irritating excipient which is solid at ordinary temperatures but liquid at the rectal temperature and will therefore melt in the rectum to release the drug. Such materials are cocoa butter and polyethylene glycols. [0076] For topical use, creams, ointments, jellies, solutions or suspensions, etc., containing the compounds of the present invention are employed. (For purposes of this application, topical application shall include mouthwashes and gargles).

[0077] According to one embodiment, the invention relates to a method of inhibiting protein kinase activity in a biological sample comprising the step of contacting said biological sample with a compound of this invention, or a composition comprising said compound. In some embodiments, the present invention provides a method of inhibiting JAK2 activity in a biological sample comprising the step of contacting said biological sample with a compound of this invention, or a composition comprising said compound.

[0078] The term "biological sample", as used herein, includes, without limitation, cell cultures or extracts thereof; biopsied material obtained from a mammal or extracts thereof; and blood, saliva, urine, feces, semen, tears, or other body fluids or extracts thereof.

[0079] Another embodiment of the present invention relates to a method of inhibiting protein kinase activity in a patient comprising the step of administering to said patient a compound of the present invention, or a composition comprising said compound. In some embodiments, the present invention provides a method of inhibiting JAK2 activity in a patient comprising the step of administering to said patient a compound of the present invention, or a composition comprising said compound.

[0080] The compounds of this invention, or pharmaceutical compositions thereof, may also be incorporated into compositions for coating an implantable medical device, such as prostheses, artificial valves, vascular grafts, stents and catheters. Vascular stents, for example, have been used to overcome restenosis (re-narrowing of the vessel wall after injury). However, patients using stents or other implantable devices risk clot formation or platelet activation. These unwanted effects may be prevented or mitigated by pre-coating the device with a pharmaceutically acceptable composition comprising a kinase inhibitor. Implantable devices coated with a compound of this invention are another embodiment of the present invention.

EXEMPLIFICATION Example 1. Synthesis of Compounds of Formula I.

[0081] Compounds of the present invention may be prepared using conditions analogous to those in Example 90 of U.S. Patent No. 7,528,143. For example, a compound of formula a

a

is combined with a compound of formula b

b

under suitable conditions to form a compound of Formula I. Such conditions include, for example, Pd₂(dba)3, Xantphos and cesium carbonate in dioxane.

Example 2. Determination of Efficacy of Selected Compounds

[0082] It will be appreciated that the activity of compounds of Formula I can be assessed according to the following methods.

[0083] BaF/3, HEL & HDF cells are grown in RPMi 1640 medium (Gibco BRL, Gaithersburg, Md.) supplemented with penicillin, streptomycin, L-giutamine, and 10% fetal bovine serum (FBS). CTLL-2 cells are grown in the same media further supplemented with 20 U/iiiL recombinant IL-2 (Hoffmann-La oche, Nutley, N.J.). Plasmid containing the human JAK2 coding sequence is available from Invitrogen (Madison, Wis.). JAK2^{V6) 7t} cDNA can be generated by using site-directed mutagenesis to introduce the V617F mutation into the human JAK2 coding sequence followed by verification using two-directional sequencing. This cDNA can be subsequently subeloned into a retroviral vector and transduced into BaF/3 cells. Permanently transduced BaF/3 cells expressing JAK2 ^{jl ,F} are selected and maintained with 1 nig/ml G418. GFP can be introduced into this cells by Ientiviral transduction using pLenti6-GFP (Invitrogen) followed by selection with blasticidin and confirmation of GFP expression using FACs analysis.

[0084] Cell proliferation assay can be performed using the XTT cell proliferation kit according to the manufacturer's instructions (Roche, Alameda, Calif). In brief, approximately 2.5x 103 cells are plated in triplicate into microtiter-plate wells in 100

RPMI growth media plus various doses of test compound. After 72 hour incubation twenty microliters of XTT is added to the wells and allowed to incubate for 4-6 hours. The colored formazan product that is formed is measured spectrophotometrically using the Vmax spectrophotometer (Molecular Devices, Sunnyvale, Calif.) at 450 nm with correction at 650 nm. IC50 values can be determined using the GraphPad Prism 4.0 software (San Diego, Calif), wherefore OD values were plotted on y-axis (linear scale) and concentration (mM) on the x-axis (log scale). Data can be subjected to a non-linear regression fit analysis and IC₅₀ values can be determined as the concentration which inhibited proliferation 50%.

[0085] BaF/3-JAK^V617F cells cultured in growth medium (RPMI, 10% FBS, 1 mg/ml G418 and 10 μg/ml blasticidin) are treated with test compound at 1, 3 and 10 μΜ for 24 h. Following harvesting cells by centrifugation at 890 RCF (relative centrifugation force) for 5 min, genomic DNA can be isolated from cell pellets using a DNA isolation kit (Puregen, Chino, Calif). 5 μg genomic DNA of each sample can be subjected to 1.2% agarose gel electrophoresis to detect genomic DNA fragmentation (DNA laddering assay). As a control, adherent normal human dermal fibroblasts (NHDF) cultured in growth medium (Cambrex, Walkersville, Md.) at 60% confluence can be treated with test compound as described above. Following 2 washes with ice cold PBS, genomic DNA is isolated from the NHDF cells for agarose gel electrophoresis.

[0086] Immunoblotting

[0087] BaF/3-JAK^V617F cells treated with test compound or vehicle control are centrifuged, washed 2* with ice-cold PBS and lysed using RIPA buffer. Protein concentration can be determined using the BCA method (Pierce, Rockford, 111.) and 100 μg of total cellular protein of each sample in l Laemmli buffer can be subjected to Western blot analysis. The protein blot can be probed with an anti-phospho-STAT5 (Tyr694/699) (Upstate Biotechnology, Charlottesville, Va.), subsequently can be stripped and re-probed with an anti-STAT5 antibody (Cell Signaling Technology, Danvers, Mass.). The phospho-STAT5 or STAT5 protein can be visualized by the enhanced chemoluminescence method (Pierce). In vivo signaling studies can be performed in a similar fashion. Briefly, on day 11 after cell injection, animals are orally dosed with either vehicle or 100 mg/kg of test compound. Spleens are harvested 7 h after dosing and quickly homogenized in a FastPrep machine (Qbiogen, Irvine, Calif). 100 μg of each spleen homogenate can be subjected to Western blot analysis. The protein blot can be probed with an anti-phospho-STAT5 (Tyr694/699) and subsequently with an anti-STAT5 antibody and can be visualized by the enhanced chemoluminescence method.

[0003] It will be appreciated that, although the general methods depict the synthesis of certain compounds of the present invention, the above general methods, and other methods known to one of ordinary skill in the art, can be applied to all compounds and subclasses and species of each of these compounds, as described herein. While a number of embodiments of this invention are described herein, it is apparent that the basic examples may be altered to provide other embodiments that utilize the compounds and methods of this invention. Therefore, it will be appreciated that the scope of this invention is to be defined by the appended claims rather than by the specific embodiments that have been represented by way of example.

Claims

We claim:

1. A compound of Formula

I

or a harmaceutically acceptable salt thereof, wherein:

2a

R 2b

R is

_R3a

-(-R³

R³ is R 3c and

R^{8 '}, R^9a, R^9a', R⁹, R^{9 '}, R^xa, R^x, R^{x '}, R^xc, R^ya, R^ya', R^y andR^yyb^D' is independently selected from hydrogen or deuterium;

R', R' , R^8a, R^8a', R⁸, R^{8 '}, R^9a, R^9a', R⁹, R^{9 '}, R^xa, R^x, R^{x '}, R^xc, R^ya, R^ya', R^y andR y^yt">' i .s deuterium. The compo compound is of Formula Il-a or Formula Ill-a:

Il-a in-a

harmaceutically acceptable salt thereof.

The compo Formula Ill-b:

harmaceutically acceptable salt thereof.

The compound of claim 1 , wherein the compound is of Formula II-c or Formula III-c:

The compound of claim 1, wherein the compound is of Formula Il-d or Formula Ill-d:

or a pharmaceutically acceptable salt thereof.

6 The compound of any one of claims 1-5, wherein the compound is selected from those compounds set forth in Tables 1-8.

7. The compound of claim 1 , wherein the compound is of Formula IV:

or a pharmaceutically acceptable salt thereof.

8. The compound of claim 7, wherein the compound is selected from those compounds set forth in Table 9 or Table 10.

9. A composition comprising a compound according to any of claims 1-8 and a pharmaceutically acceptable excipient.

10. A method for inhibiting the activity of JAK2, or a mutant thereof, in a patient or in a biological sample comprising the step of administering to said patient or contacting said biological sample with a compound according to any of claims 1-8.

11. A method for treating a JAK2-mediated disorder in a patient in need thereof, comprising the step of administering to said patient a compound according to any of claims 1-8.

12. The method according to claim 11, wherein the JAK2-mediated disorder is a myeloproliferative disorder.

13. The method according to claim 12, wherein the myeloproliferative disorder is selected from primary myelofibrosis, secondary myelofibrosis, polycythemia vera, essential thrombocythemia, post polycythemia vera and post essential thrombocythemia.

14. The method of claim 13, wherein the myelofibrosis is primary myelofibrosis.

15. The method of claim 13, wherein the myelofibrosis is secondary myelofibrosis.