CN107209118B - 在自体荧光存在下生物材料中目标荧光团的成像 - Google Patents
在自体荧光存在下生物材料中目标荧光团的成像 Download PDFInfo
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- CN107209118B CN107209118B CN201580064648.8A CN201580064648A CN107209118B CN 107209118 B CN107209118 B CN 107209118B CN 201580064648 A CN201580064648 A CN 201580064648A CN 107209118 B CN107209118 B CN 107209118B
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Abstract
Description
Claims (35)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201462056830P | 2014-09-29 | 2014-09-29 | |
US62/056830 | 2014-09-29 | ||
PCT/CA2015/050973 WO2016049756A1 (en) | 2014-09-29 | 2015-09-28 | Imaging a target fluorophore in a biological material in the presence of autofluorescence |
Publications (2)
Publication Number | Publication Date |
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CN107209118A CN107209118A (zh) | 2017-09-26 |
CN107209118B true CN107209118B (zh) | 2021-05-28 |
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Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070122344A1 (en) | 2005-09-02 | 2007-05-31 | University Of Rochester Medical Center Office Of Technology Transfer | Intraoperative determination of nerve location |
US20080161744A1 (en) * | 2006-09-07 | 2008-07-03 | University Of Rochester Medical Center | Pre-And Intra-Operative Localization of Penile Sentinel Nodes |
US8406860B2 (en) | 2008-01-25 | 2013-03-26 | Novadaq Technologies Inc. | Method for evaluating blush in myocardial tissue |
US10219742B2 (en) | 2008-04-14 | 2019-03-05 | Novadaq Technologies ULC | Locating and analyzing perforator flaps for plastic and reconstructive surgery |
ES2671710T3 (es) | 2008-05-02 | 2018-06-08 | Novadaq Technologies ULC | Métodos para la producción y uso de eritrocitos cargados con sustancias para la observación y el tratamiento de la hemodinámica microvascular |
US10492671B2 (en) | 2009-05-08 | 2019-12-03 | Novadaq Technologies ULC | Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest |
EP2863801B8 (en) | 2012-06-21 | 2024-06-12 | Stryker Corporation | Quantification and analysis of angiography and perfusion |
WO2016049756A1 (en) * | 2014-09-29 | 2016-04-07 | Novadaq Technologies Inc. | Imaging a target fluorophore in a biological material in the presence of autofluorescence |
JP6487544B2 (ja) | 2014-10-09 | 2019-03-20 | ノバダック テクノロジーズ ユーエルシー | 蛍光媒介光電式容積脈波記録法を用いた組織中の絶対血流の定量化 |
US10614571B2 (en) * | 2015-12-10 | 2020-04-07 | Qiagen Gmbh | Object classification in digital images |
TWI583952B (zh) * | 2016-01-21 | 2017-05-21 | 威力暘電子股份有限公司 | ***物之潛血檢測方法及潛血檢測裝置 |
EP4242743A3 (en) | 2017-02-10 | 2023-10-18 | Stryker European Operations Limited | Open-field handheld fluorescence imaging systems and methods |
EP3610243A4 (en) * | 2017-04-07 | 2020-12-16 | Avelas Biosciences, Inc. | RATIOMETRIC FLUORESCENCE IMAGING PROCESSES |
WO2018204583A1 (en) * | 2017-05-04 | 2018-11-08 | Vector Laboratories, Inc. | Improved immunofluorescence assays |
US11353402B2 (en) * | 2017-07-11 | 2022-06-07 | Hamamatsu Photonics K.K. | Sample observation device and sample observation method |
EP3731724A4 (en) * | 2017-12-27 | 2021-10-13 | Ethicon LLC | FLUORESCENT IMAGING IN A LIGHT ENVIRONMENT |
CN112384787A (zh) | 2018-05-03 | 2021-02-19 | 阿科亚生物科学股份有限公司 | 多光谱样本成像 |
JP2020020791A (ja) * | 2018-07-24 | 2020-02-06 | ソニー株式会社 | 情報処理装置、情報処理方法、情報処理システム、およびプログラム |
US10753875B1 (en) * | 2019-01-31 | 2020-08-25 | Rarecyte, Inc. | Spectral unmixing of spectroscopic emission images |
US10724956B1 (en) * | 2019-02-01 | 2020-07-28 | Essen Instruments, Inc. | Spectral unmixing |
CN113424050A (zh) * | 2019-02-13 | 2021-09-21 | 文塔纳医疗***公司 | 用于计算多通道图像中的自体荧光贡献的***和方法 |
TWI726614B (zh) * | 2020-02-12 | 2021-05-01 | 財團法人國家實驗研究院 | 生物螢光影像的檢測方法 |
WO2022011276A1 (en) | 2020-07-09 | 2022-01-13 | Axon Imaging, Llc | Advanced nervous tissue imaging system |
WO2022010519A1 (en) * | 2020-07-09 | 2022-01-13 | Axon Imaging, Llc | Tissue imaging system |
EP3961194B1 (en) * | 2020-08-25 | 2023-11-08 | Korea Advanced Institute of Science and Technology | Method and apparatus for multiplexed imaging of biomolecules through iterative unmixing of fluorophore signals |
KR102655200B1 (ko) * | 2020-08-25 | 2024-04-08 | 한국과학기술원 | 반복색분리를 통한 분자 다중 이미징 방법 및 장치 |
US11408825B2 (en) * | 2020-08-28 | 2022-08-09 | Hong Kong Applied Science and Technology Research Institute Company Limited | Forensic detector and the system thereof |
US20220079447A1 (en) * | 2020-09-15 | 2022-03-17 | Sensors Unlimited, Inc. | Visualization for fluorescent guided imaging |
EP4283282A1 (en) * | 2021-01-22 | 2023-11-29 | Toho University | Autofluorescence quenching device |
WO2023059956A1 (en) * | 2021-10-05 | 2023-04-13 | Mazel Charles H | Method and system for distinguishing a fluorescent subject of interest from other fluorescent subjects or fluorescent background |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1636506A (zh) * | 2003-12-12 | 2005-07-13 | 强生消费者公司 | 评估皮肤与个体之整体健康的方法 |
CN1678239A (zh) * | 2002-08-01 | 2005-10-05 | 约翰霍普金斯大学 | 利用荧光鉴定分子结构和使体腔起皱的细胞类型的技术 |
WO2007012301A1 (de) * | 2005-07-29 | 2007-02-01 | Biocam Gmbh | Verfahren sowie messsystem zur ermittlung der sauerstoffpartialdruckverteilung in zumindest einem gewebeflächenabschnitt, insbesondere hautgewebeflächenabschnitt |
CN101484067A (zh) * | 2006-07-07 | 2009-07-15 | 皇家飞利浦电子股份有限公司 | 光学成像***和方法 |
CN102026668A (zh) * | 2008-05-14 | 2011-04-20 | 诺瓦达克技术公司 | 用于神经成像的包括与病毒组分结合的荧光染料的成像法和组合物 |
WO2012038824A1 (en) * | 2010-09-20 | 2012-03-29 | Novadaq Technologies Inc. | Locating and analyzing perforator flaps for plastic and reconstructive surgery |
Family Cites Families (360)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5854822B2 (ja) | 1975-09-11 | 1983-12-06 | ミノルタ株式会社 | コウデンシキセイタイケイソクキ |
US4109647A (en) | 1977-03-16 | 1978-08-29 | The United States Of America As Represented By The Secretary Of The Department Of Health, Education And Welfare | Method of and apparatus for measurement of blood flow using coherent light |
US4263916A (en) | 1978-03-27 | 1981-04-28 | University Of Southern California | Image averaging for angiography by registration and combination of serial images |
US4162405A (en) | 1978-05-23 | 1979-07-24 | Britton Chance | Flying spot fluoro-meter for oxidized flavoprotein and reduced pyridine nucleotide |
US4200801A (en) | 1979-03-28 | 1980-04-29 | The United States Of America As Represented By The United States Department Of Energy | Portable spotter for fluorescent contaminants on surfaces |
US4394199A (en) | 1981-09-08 | 1983-07-19 | Agnus Chemical Company | Explosive emulsion composition |
JPS58141135A (ja) | 1981-10-20 | 1983-08-22 | 富士写真フイルム株式会社 | 固体イメ−ジセンサを用いた内視鏡の画像伝送方式 |
EP0091805B1 (en) | 1982-04-08 | 1989-07-26 | Olympus Optical Co., Ltd. | Endoscope focus state detectors |
JPS58222331A (ja) | 1982-06-21 | 1983-12-24 | Sony Corp | 文字情報再生装置 |
JPS5940830A (ja) | 1982-08-31 | 1984-03-06 | 浜松ホトニクス株式会社 | レ−ザ光パルスを用いた癌の診断装置 |
JPS5969721A (ja) | 1982-10-15 | 1984-04-20 | Olympus Optical Co Ltd | 内視鏡計測装置 |
JPS5970903A (ja) | 1982-10-15 | 1984-04-21 | Olympus Optical Co Ltd | 内視鏡自動計測装置 |
US4541438A (en) | 1983-06-02 | 1985-09-17 | The Johns Hopkins University | Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light |
US4532918A (en) | 1983-10-07 | 1985-08-06 | Welch Allyn Inc. | Endoscope signal level control |
JPS60256443A (ja) | 1984-05-31 | 1985-12-18 | オムロン株式会社 | 画像計測装置 |
US4559557A (en) | 1984-06-01 | 1985-12-17 | General Electric Company | Region-of-interest digital subtraction angiography |
SE455646B (sv) | 1984-10-22 | 1988-07-25 | Radians Innova Ab | Fluorescensanordning |
US4718417A (en) | 1985-03-22 | 1988-01-12 | Massachusetts Institute Of Technology | Visible fluorescence spectral diagnostic for laser angiosurgery |
US5125404A (en) | 1985-03-22 | 1992-06-30 | Massachusetts Institute Of Technology | Apparatus and method for obtaining spectrally resolved spatial images of tissue |
US5318024A (en) | 1985-03-22 | 1994-06-07 | Massachusetts Institute Of Technology | Laser endoscope for spectroscopic imaging |
DE3511255A1 (de) | 1985-03-28 | 1986-10-02 | Grün Optik Wetzlar GmbH, 6330 Wetzlar | Anordnung zur individuellen regelung der intensitaet mehrer spektrallampen |
CN85100424B (zh) | 1985-04-01 | 1986-10-29 | 上海医疗器械研究所 | 恶性肿瘤固有荧光诊断仪 |
US4619249A (en) | 1985-07-24 | 1986-10-28 | Kim Landry | Transcutaneous intravenous illuminator |
AT387860B (de) | 1985-09-16 | 1989-03-28 | Optical Sensing Technology | Verfahren und vorrichtung zur tumordiagnose mittels sera |
US4719508A (en) | 1985-10-02 | 1988-01-12 | Olympus Optical Co., Ltd. | Endoscopic photographing apparatus |
US5134662A (en) | 1985-11-04 | 1992-07-28 | Cell Analysis Systems, Inc. | Dual color camera microscope and methodology for cell staining and analysis |
US5042494A (en) | 1985-11-13 | 1991-08-27 | Alfano Robert R | Method and apparatus for detecting cancerous tissue using luminescence excitation spectra |
US4930516B1 (en) | 1985-11-13 | 1998-08-04 | Laser Diagnostic Instr Inc | Method for detecting cancerous tissue using visible native luminescence |
US4774568A (en) | 1986-01-27 | 1988-09-27 | Kabushiki Kaisha Toshiba | Endoscopic apparatus |
JPS62247232A (ja) | 1986-04-21 | 1987-10-28 | Agency Of Ind Science & Technol | 蛍光測定装置 |
GB2203831B (en) | 1986-07-07 | 1991-02-06 | Academy Of Applied Sciences | Apparatus and method for the diagnosis of malignant tumours |
JPH0763443B2 (ja) | 1986-09-30 | 1995-07-12 | 株式会社東芝 | 電子内視鏡 |
JPS63122421A (ja) | 1986-11-12 | 1988-05-26 | 株式会社東芝 | 内視鏡装置 |
US5255087A (en) | 1986-11-29 | 1993-10-19 | Olympus Optical Co., Ltd. | Imaging apparatus and endoscope apparatus using the same |
JP2572394B2 (ja) | 1987-03-19 | 1997-01-16 | オリンパス光学工業株式会社 | 電子内視鏡 |
JPH0783B2 (ja) | 1987-03-30 | 1995-01-11 | 株式会社東芝 | 電子内視鏡装置 |
US4986262A (en) | 1987-03-31 | 1991-01-22 | Kabushiki Kaisha Toshiba | Measuring endoscope |
US4852579A (en) | 1987-04-20 | 1989-08-01 | Karl Storz Endoscopy Gmbh And Company | Photocharacterization and treatment of normal abnormal and ectopic endometrium |
US4900934A (en) | 1987-07-15 | 1990-02-13 | University Of Utah | Apparatus for simultaneous visualization and measurement of fluorescence from fluorescent dye-treated cell preparations and solutions |
JPH0824668B2 (ja) | 1987-09-14 | 1996-03-13 | オリンパス光学工業株式会社 | 電子内視鏡装置 |
US4858001A (en) | 1987-10-08 | 1989-08-15 | High-Tech Medical Instrumentation, Inc. | Modular endoscopic apparatus with image rotation |
JPH01160525A (ja) | 1987-12-17 | 1989-06-23 | Olympus Optical Co Ltd | 内視鏡 |
DE3906860A1 (de) | 1988-03-08 | 1989-09-28 | Fraunhofer Ges Forschung | Vorrichtung zum herstellen einer angiographie |
JPH01236879A (ja) | 1988-03-17 | 1989-09-21 | Canon Inc | 画像符号化装置 |
JPH06105190B2 (ja) | 1988-03-31 | 1994-12-21 | 工業技術院長 | 信号解析装置 |
US4998972A (en) | 1988-04-28 | 1991-03-12 | Thomas J. Fogarty | Real time angioscopy imaging system |
US5078150A (en) | 1988-05-02 | 1992-01-07 | Olympus Optical Co., Ltd. | Spectral diagnosing apparatus with endoscope |
IL90188A0 (en) | 1988-05-18 | 1989-12-15 | Cryopharm Corp | Process and medium for the lyophilization of erythrocytes |
US4938205A (en) | 1988-05-27 | 1990-07-03 | The University Of Connecticut | Endoscope with traced raster and elemental photodetectors |
US5178616A (en) | 1988-06-06 | 1993-01-12 | Sumitomo Electric Industries, Ltd. | Method and apparatus for intravascular laser surgery |
US4995396A (en) | 1988-12-08 | 1991-02-26 | Olympus Optical Co., Ltd. | Radioactive ray detecting endoscope |
US5353799A (en) | 1991-01-22 | 1994-10-11 | Non Invasive Technology, Inc. | Examination of subjects using photon migration with high directionality techniques |
US5419323A (en) | 1988-12-21 | 1995-05-30 | Massachusetts Institute Of Technology | Method for laser induced fluorescence of tissue |
JP2987816B2 (ja) | 1989-01-30 | 1999-12-06 | オリンパス光学工業株式会社 | 蛍光観察装置 |
DE3903019A1 (de) | 1989-02-02 | 1990-08-09 | Hell Rudolf Dr Ing Gmbh | Optische farbteiler-anordnung |
SE8900612D0 (sv) | 1989-02-22 | 1989-02-22 | Jonas Johansson | Vaevnadskarakterisering utnyttjande ett blodfritt fluorescenskriterium |
EP0466828A1 (en) | 1989-04-14 | 1992-01-22 | Massachusetts Institute Of Technology | Spectral diagnosis of diseased tissue |
US5421337A (en) | 1989-04-14 | 1995-06-06 | Massachusetts Institute Of Technology | Spectral diagnosis of diseased tissue |
KR100190423B1 (ko) | 1989-06-06 | 1999-06-01 | 기타지마 요시도시 | 에멀젼마스크 등의결함 수정방법 및 장치 |
US4993404A (en) | 1989-06-26 | 1991-02-19 | Lane Timothy G | Fluoroscopy switching device |
CN1049781A (zh) | 1989-09-02 | 1991-03-13 | 住友电气工业株式会社 | 用于血管外科的激光手术器械 |
JPH0614921B2 (ja) | 1989-09-29 | 1994-03-02 | 浜松ホトニクス株式会社 | 生体組織螢光観察装置 |
US5150292A (en) | 1989-10-27 | 1992-09-22 | Arch Development Corporation | Method and system for determination of instantaneous and average blood flow rates from digital angiograms |
EP0439018B1 (en) | 1990-01-08 | 1995-11-08 | Ernest Feiler, M.D. | Diagnostic method for checking the blood flow |
US5091652A (en) | 1990-01-12 | 1992-02-25 | The Regents Of The University Of California | Laser excited confocal microscope fluorescence scanner and method |
US5420628A (en) | 1990-01-16 | 1995-05-30 | Research Development Foundation | Video densitometer with determination of color composition |
US5131398A (en) | 1990-01-22 | 1992-07-21 | Mediscience Technology Corp. | Method and apparatus for distinguishing cancerous tissue from benign tumor tissue, benign tissue or normal tissue using native fluorescence |
US4995398A (en) | 1990-04-30 | 1991-02-26 | Turnidge Patrick A | Coronary angiography imaging system |
US5071417A (en) | 1990-06-15 | 1991-12-10 | Rare Earth Medical Lasers, Inc. | Laser fusion of biological materials |
US6196226B1 (en) | 1990-08-10 | 2001-03-06 | University Of Washington | Methods and apparatus for optically imaging neuronal tissue and activity |
US5438989A (en) | 1990-08-10 | 1995-08-08 | Hochman; Darryl | Solid tumor, cortical function, and nerve tissue imaging methods and device |
US5845639A (en) | 1990-08-10 | 1998-12-08 | Board Of Regents Of The University Of Washington | Optical imaging methods |
US6671540B1 (en) | 1990-08-10 | 2003-12-30 | Daryl W. Hochman | Methods and systems for detecting abnormal tissue using spectroscopic techniques |
US5465718A (en) | 1990-08-10 | 1995-11-14 | Hochman; Daryl | Solid tumor, cortical function, and nerve tissue imaging methods and device |
US5699798A (en) | 1990-08-10 | 1997-12-23 | University Of Washington | Method for optically imaging solid tumor tissue |
US5997844A (en) | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
JPH04297236A (ja) | 1991-03-26 | 1992-10-21 | Toshiba Corp | ディジタルフルオログラフィ装置 |
JPH04307024A (ja) | 1991-04-02 | 1992-10-29 | Olympus Optical Co Ltd | 電子内視鏡装置 |
US5318023A (en) | 1991-04-03 | 1994-06-07 | Cedars-Sinai Medical Center | Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle |
US5377676A (en) | 1991-04-03 | 1995-01-03 | Cedars-Sinai Medical Center | Method for determining the biodistribution of substances using fluorescence spectroscopy |
US6485413B1 (en) | 1991-04-29 | 2002-11-26 | The General Hospital Corporation | Methods and apparatus for forward-directed optical scanning instruments |
US5117466A (en) | 1991-04-30 | 1992-05-26 | The United States Of America As Represented By The United States Department Of Energy | Integrated fluorescence analysis system |
CA2042075C (en) | 1991-05-08 | 2001-01-23 | Branko Palcic | Endoscopic imaging system |
US5225883A (en) | 1991-06-05 | 1993-07-06 | The Babcock & Wilcox Company | Video temperature monitor |
SE468925B (sv) | 1991-08-22 | 1993-04-19 | Gert Nilsson | En metod och en anordning foer att reducera den avstaandsberoende foerstaerkningsfaktorn vid maetning av stroemningsroerelser med en bildgivande laser-doppler teknik, i synnerhet vid maetning av blodperfusion genom en vaevnad |
US5377686A (en) | 1991-10-11 | 1995-01-03 | The University Of Connecticut | Apparatus for detecting leakage from vascular tissue |
JP3297725B2 (ja) | 1991-12-09 | 2002-07-02 | 国立循環器病センター総長 | 造影血管高精度管径計測装置 |
US5214503A (en) | 1992-01-31 | 1993-05-25 | The United States Of America As Represented By The Secretary Of The Army | Color night vision camera system |
US5235984A (en) | 1992-03-30 | 1993-08-17 | Hewlett-Packard Company | On-line acoustic densitometry tool for use with an ultrasonic imaging system |
US6096289A (en) | 1992-05-06 | 2000-08-01 | Immunomedics, Inc. | Intraoperative, intravascular, and endoscopic tumor and lesion detection, biopsy and therapy |
DE4220633C1 (de) | 1992-06-24 | 1994-02-03 | Wolf Gmbh Richard | Vorrichtung zur Lichtversorgung von Endoskopen |
US5279298A (en) | 1992-11-20 | 1994-01-18 | The Johns Hopkins University | Method and apparatus to identify and treat neovascular membranes in the eye |
US5733721A (en) * | 1992-11-20 | 1998-03-31 | The Board Of Regents Of The University Of Oklahoma | Cell analysis method using quantitative fluorescence image analysis |
GB2275198B (en) | 1993-02-18 | 1997-03-26 | Central Research Lab Ltd | Apparatus for irradiating an area with a controllable pattern of light |
US5437274A (en) | 1993-02-25 | 1995-08-01 | Gholam A. Peyman | Method of visualizing submicron-size vesicles and particles in blood circulation |
JP3228627B2 (ja) | 1993-03-19 | 2001-11-12 | オリンパス光学工業株式会社 | 内視鏡用画像処理装置 |
US5431161A (en) | 1993-04-15 | 1995-07-11 | Adac Laboratories | Method and apparatus for information acquistion, processing, and display within a medical camera system |
US5421339A (en) | 1993-05-12 | 1995-06-06 | Board Of Regents, The University Of Texas System | Diagnosis of dysplasia using laser induced fluoroescence |
US5394199A (en) | 1993-05-17 | 1995-02-28 | The Johns Hopkins University | Methods and apparatus for improved visualization of choroidal blood flow and aberrant vascular structures in the eye using fluorescent dye angiography |
WO1996009792A1 (en) | 1993-05-17 | 1996-04-04 | The Johns Hopkins University | Improved visualization of choroidal blood flow and aberrant vascular structures in the eye |
US5424841A (en) | 1993-05-28 | 1995-06-13 | Molecular Dynamics | Apparatus for measuring spatial distribution of fluorescence on a substrate |
US5673701A (en) | 1994-10-07 | 1997-10-07 | Non Invasive Technology, Inc. | Optical techniques for examination of biological tissue |
DK75593D0 (zh) | 1993-06-25 | 1993-06-25 | Novo Nordisk As | |
US5365057A (en) | 1993-07-02 | 1994-11-15 | Litton Systems, Inc. | Light-weight night vision device |
US5371355A (en) | 1993-07-30 | 1994-12-06 | Litton Systems, Inc. | Night vision device with separable modular image intensifier assembly |
JP3224640B2 (ja) * | 1993-07-30 | 2001-11-05 | 三菱重工業株式会社 | Lifによる濃度計測装置及び方法 |
JPH0765154A (ja) | 1993-08-31 | 1995-03-10 | Toshiba Corp | 血管像の定量解析装置及びその定量解析方法 |
JPH0779955A (ja) | 1993-09-14 | 1995-03-28 | Toshiba Corp | X線撮影装置 |
JPH07155291A (ja) | 1993-12-03 | 1995-06-20 | Olympus Optical Co Ltd | 蛍光観察装置 |
JPH07155290A (ja) | 1993-12-03 | 1995-06-20 | Olympus Optical Co Ltd | 内視鏡装置 |
JP3285265B2 (ja) | 1993-12-03 | 2002-05-27 | オリンパス光学工業株式会社 | 蛍光観察装置 |
JP3283128B2 (ja) | 1993-12-03 | 2002-05-20 | オリンパス光学工業株式会社 | 蛍光観察内視鏡装置 |
JPH07222712A (ja) | 1994-02-10 | 1995-08-22 | Olympus Optical Co Ltd | 蛍光内視鏡装置 |
JP3194660B2 (ja) | 1993-12-03 | 2001-07-30 | オリンパス光学工業株式会社 | 蛍光観察装置 |
JP3487933B2 (ja) | 1993-12-03 | 2004-01-19 | オリンパス株式会社 | 蛍光観察装置 |
US5453448A (en) | 1993-12-09 | 1995-09-26 | Pdt Cardiovascular, Inc. | In vivo method for estimating the lipid contant of an atheromatous lesion |
JP3275159B2 (ja) | 1993-12-17 | 2002-04-15 | 日本光電工業株式会社 | 循環血液量測定装置 |
US5496369A (en) | 1994-02-09 | 1996-03-05 | University Of Iowa Research Foundation | Human cerebral cortex neural prosthetic |
US5656498A (en) | 1994-02-22 | 1997-08-12 | Nippon Telegraph And Telephone Corporation | Freeze-dried blood cells, stem cells and platelets, and manufacturing method for the same |
US5707986A (en) | 1994-03-14 | 1998-01-13 | Miller; Joan W. | Angiographic method using green porphyrins in primate eyes |
JPH07250812A (ja) | 1994-03-15 | 1995-10-03 | Olympus Optical Co Ltd | 蛍光診断装置 |
JPH07250804A (ja) | 1994-03-15 | 1995-10-03 | Olympus Optical Co Ltd | 蛍光観察装置 |
US5491343A (en) | 1994-03-25 | 1996-02-13 | Brooker; Gary | High-speed multiple wavelength illumination source, apparatus containing the same, and applications thereof to methods of irradiating luminescent samples and of quantitative luminescence ratio microscopy |
US5590660A (en) | 1994-03-28 | 1997-01-07 | Xillix Technologies Corp. | Apparatus and method for imaging diseased tissue using integrated autofluorescence |
EP0758251A1 (en) | 1994-05-03 | 1997-02-19 | Molecular Biosystems, Inc. | Composition for ultrasonically quantitating myocardial perfusion |
US5519534A (en) | 1994-05-25 | 1996-05-21 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Irradiance attachment for an optical fiber to provide a uniform level of illumination across a plane |
JP3641495B2 (ja) | 1994-07-19 | 2005-04-20 | 株式会社日立メディコ | 医用画像診断装置 |
CA2141181A1 (en) | 1994-09-21 | 1996-03-22 | Kimberly-Clark Worldwide, Inc. | Wet-resilient webs |
ATE255845T1 (de) | 1994-09-26 | 2003-12-15 | Univ Johns Hopkins | Optische darstellung des blutkreislaufs und von abnormalen gefässstrukturen in der aderhaut des auges |
US5627907A (en) | 1994-12-01 | 1997-05-06 | University Of Pittsburgh | Computerized detection of masses and microcalcifications in digital mammograms |
US5935942A (en) | 1994-12-14 | 1999-08-10 | Zeimer; Ran | Selective and non-invasive visualization or treatment of vasculature |
US5951980A (en) | 1995-01-06 | 1999-09-14 | Leuven Research & Development Vzw | Identification, production and use of new staphylokinase derivatives with reduced immunogenicity |
GB9502065D0 (en) | 1995-02-02 | 1995-03-22 | Nycomed Imaging As | Contrast media |
JPH08224240A (ja) | 1995-02-22 | 1996-09-03 | Olympus Optical Co Ltd | 蛍光診断装置 |
JPH08224208A (ja) | 1995-02-22 | 1996-09-03 | Olympus Optical Co Ltd | 蛍光観察内視鏡装置 |
JP3560671B2 (ja) | 1995-02-23 | 2004-09-02 | オリンパス株式会社 | 蛍光観察装置 |
JP3411737B2 (ja) | 1995-03-03 | 2003-06-03 | ペンタックス株式会社 | 生体の蛍光診断装置 |
US7236815B2 (en) | 1995-03-14 | 2007-06-26 | The Board Of Regents Of The University Of Texas System | Method for probabilistically classifying tissue in vitro and in vivo using fluorescence spectroscopy |
US5576013A (en) | 1995-03-21 | 1996-11-19 | Eastern Virginia Medical School | Treating vascular and neoplastic tissues |
AU721276B2 (en) | 1995-04-04 | 2000-06-29 | Wound Healing Of Oklahoma | Cancer treatment by photodynamic therapy, in combination with an immunoadjuvant |
US5689241A (en) | 1995-04-24 | 1997-11-18 | Clarke, Sr.; James Russell | Sleep detection and driver alert apparatus |
US5743266A (en) | 1995-04-25 | 1998-04-28 | Molecular Biosystems, Inc. | Method for processing real-time contrast enhanced ultrasonic images |
US5623930A (en) | 1995-05-02 | 1997-04-29 | Acuson Corporation | Ultrasound system for flow measurement |
US6032070A (en) | 1995-06-07 | 2000-02-29 | University Of Arkansas | Method and apparatus for detecting electro-magnetic reflection from biological tissue |
EP0846262A4 (en) | 1995-08-24 | 1999-11-03 | Purdue Research Foundation | IMAGING SPECTROSCOPY OF TISSUE AND OTHER STRONG DISTRIBUTING MEDIA BASED ON FLUORESCENT LIFETIME |
US5836311A (en) | 1995-09-20 | 1998-11-17 | Medtronic, Inc. | Method and apparatus for temporarily immobilizing a local area of tissue |
US5647368A (en) | 1996-02-28 | 1997-07-15 | Xillix Technologies Corp. | Imaging system for detecting diseased tissue using native fluorsecence in the gastrointestinal and respiratory tract |
US5756541A (en) | 1996-03-11 | 1998-05-26 | Qlt Phototherapeutics Inc | Vision through photodynamic therapy of the eye |
DE19613342A1 (de) | 1996-04-03 | 1997-10-09 | Philips Patentverwaltung | Automatisches Bildauswertungsverfahren |
US5766127A (en) | 1996-04-15 | 1998-06-16 | Ohmeda Inc. | Method and apparatus for improved photoplethysmographic perfusion-index monitoring |
JPH09305845A (ja) | 1996-05-13 | 1997-11-28 | Shibaura Eng Works Co Ltd | 温蔵自動販売機 |
US5662644A (en) | 1996-05-14 | 1997-09-02 | Mdlt, Inc. | Dermatological laser apparatus and method |
US5785965A (en) | 1996-05-15 | 1998-07-28 | The Board Of Trustees Of The Leland Stanford Junior Univ. | VEGF gene transfer into endothelial cells for vascular prosthesis |
JP3896176B2 (ja) | 1996-05-21 | 2007-03-22 | 浜松ホトニクス株式会社 | 近赤外線蛍光トレーサーおよび蛍光イメージング方法 |
GB9610700D0 (en) | 1996-05-22 | 1996-07-31 | Moor Instr Ltd | Apparatus for imaging microvascular blood flow |
JPH09308609A (ja) | 1996-05-24 | 1997-12-02 | Canon Inc | 眼科用画像処理装置 |
DE19635038A1 (de) | 1996-08-29 | 1998-03-12 | Pulsion Verwaltungs Gmbh & Co | Verfahren zur nicht invasiven Bestimmung des zerebralen Blutflusses mittels Nah-Infrarot-Spektroskopie |
US5851181A (en) | 1996-08-30 | 1998-12-22 | Esc Medical Systems Ltd. | Apparatus for simultaneously viewing and spectrally analyzing a portion of skin |
JP2793989B2 (ja) | 1996-09-30 | 1998-09-03 | オリンパス光学工業株式会社 | 内視鏡用光源装置の回転フィルタ |
JP3177635B2 (ja) | 1996-09-30 | 2001-06-18 | 株式会社応用光電研究室 | 周波数標準器および選択標準周波数生成方法 |
US6013265A (en) | 1996-10-22 | 2000-01-11 | University Of Maryland, Baltimore | Vaccine composition for herpes simplex virus and methods of using |
JP3713347B2 (ja) | 1996-11-25 | 2005-11-09 | オリンパス株式会社 | 蛍光内視鏡装置 |
JP3962122B2 (ja) | 1996-11-20 | 2007-08-22 | オリンパス株式会社 | 内視鏡装置 |
US6293911B1 (en) | 1996-11-20 | 2001-09-25 | Olympus Optical Co., Ltd. | Fluorescent endoscope system enabling simultaneous normal light observation and fluorescence observation in infrared spectrum |
DE19648935B4 (de) | 1996-11-26 | 2008-05-15 | IMEDOS Intelligente Optische Systeme der Medizin- und Messtechnik GmbH | Vorrichtung und Verfahren zur Untersuchung von Gefäßen |
US6086539A (en) | 1996-12-04 | 2000-07-11 | Acuson Corporation | Methods and apparatus for ultrasound image quantification |
CA2192036A1 (en) | 1996-12-04 | 1998-06-04 | Harvey Lui | Fluorescence scope system for dermatologic diagnosis |
DE69732696T2 (de) | 1997-01-08 | 2006-04-13 | Biosense Webster, Inc., Diamond Bar | Überwachung der myokardialen revaskularisation |
JP3771985B2 (ja) | 1997-01-20 | 2006-05-10 | オリンパス株式会社 | 蛍光観察内視鏡装置 |
JPH10210367A (ja) | 1997-01-20 | 1998-08-07 | Olympus Optical Co Ltd | 電子的撮像装置 |
US5965356A (en) | 1997-01-31 | 1999-10-12 | University Of Maryland, Baltimore | Herpes simplex virus type specific seroassay |
US6122042A (en) | 1997-02-07 | 2000-09-19 | Wunderman; Irwin | Devices and methods for optically identifying characteristics of material objects |
US6466687B1 (en) | 1997-02-12 | 2002-10-15 | The University Of Iowa Research Foundation | Method and apparatus for analyzing CT images to determine the presence of pulmonary tissue pathology |
US6081612A (en) | 1997-02-28 | 2000-06-27 | Electro Optical Sciences Inc. | Systems and methods for the multispectral imaging and characterization of skin tissue |
US6008889A (en) | 1997-04-16 | 1999-12-28 | Zeng; Haishan | Spectrometer system for diagnosis of skin disease |
EP0975258A1 (en) | 1997-04-17 | 2000-02-02 | Avimo Group Limited | Ocular microcirculation examination and treatment apparatus |
GB9710049D0 (en) | 1997-05-19 | 1997-07-09 | Nycomed Imaging As | Method |
US6280386B1 (en) | 1997-06-16 | 2001-08-28 | The Research Foundation Of The City University Of New York | Apparatus for enhancing the visibility of a luminous object inside tissue and methods for same |
AU7934498A (en) | 1997-06-27 | 1999-01-19 | Toa Medical Electronics Co., Ltd. | Living body inspecting apparatus and noninvasive blood analyzer using the same |
US6342611B1 (en) | 1997-10-10 | 2002-01-29 | Cytovia, Inc. | Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof |
DE19747172C2 (de) | 1997-10-24 | 2000-04-13 | Pulsion Verwaltungs Gmbh & Co | Vorrichtung zur Feststellung eines Perikardergusses |
JP3370912B2 (ja) | 1997-11-14 | 2003-01-27 | 松下電器産業株式会社 | 撮像装置 |
US6306642B1 (en) | 1997-11-24 | 2001-10-23 | Quidel Corporation | Enzyme substrate delivery and product registration in one step enzyme immunoassays |
JPH11155812A (ja) | 1997-12-02 | 1999-06-15 | Olympus Optical Co Ltd | 蛍光観察装置 |
US5919616A (en) | 1997-12-12 | 1999-07-06 | Aurx, Inc. | Serological assay for herpes |
JPH11183358A (ja) | 1997-12-25 | 1999-07-09 | Kowa Co | 蛍光粒子撮像用容器 |
DE19800312A1 (de) | 1998-01-07 | 1999-07-08 | Wolf Gmbh Richard | Diagnosegerät zur bildgebenden Aufnahme fluoreszierender biologischer Gewebebereiche |
US6054131A (en) | 1998-01-16 | 2000-04-25 | University Of Maryland Baltimore | Vaccine composition for herpes simplex virus and method of using |
EP1054618B1 (en) | 1998-02-11 | 2006-12-20 | Non-Invasive Technology, Inc. | Detection, imaging and characterization of breast tumors |
US6113588A (en) | 1998-03-13 | 2000-09-05 | Corvascular, Inc. | Transillumination catheter and method |
EP1066537A1 (en) | 1998-03-18 | 2001-01-10 | Magnetic Imaging Technologies Inc. | MR METHODS FOR IMAGING PULMONARY AND CARDIAC VASCULATURE AND EVALUATING BLOOD FLOW USING DISSOLVED POLARIZED ?129 Xe |
US6462770B1 (en) | 1998-04-20 | 2002-10-08 | Xillix Technologies Corp. | Imaging system with automatic gain control for reflectance and fluorescence endoscopy |
US6399354B1 (en) | 1998-07-31 | 2002-06-04 | President And Fellows Of Harvard College | Replication-competent virus expressing a detectable fusion protein |
US6178340B1 (en) | 1998-08-24 | 2001-01-23 | Eduardo Svetliza | Three-dimensional infrared imager for subcutaneous puncture and study of vascular network |
CA2413033A1 (en) | 1998-09-18 | 2000-03-30 | Schering Aktiengesellschaft | Near infrared fluorescent contrast agent and fluorescence imaging |
US6162242A (en) | 1999-01-21 | 2000-12-19 | Peyman; Gholam A. | Selective photodynamic treatment |
AU3349200A (en) | 1999-01-26 | 2000-08-07 | Newton Laboratories, Inc. | Autofluorescence imaging system for endoscopy |
GB9903394D0 (en) | 1999-02-15 | 1999-04-07 | Avimo Group Limited | Treatment of neovascularization and other eye diseases |
US6331703B1 (en) | 1999-03-12 | 2001-12-18 | Ethicon Endo-Surgery, Inc. | Guidance method for radiation detection |
US6167297A (en) | 1999-05-05 | 2000-12-26 | Benaron; David A. | Detecting, localizing, and targeting internal sites in vivo using optical contrast agents |
US6217848B1 (en) | 1999-05-20 | 2001-04-17 | Mallinckrodt Inc. | Cyanine and indocyanine dye bioconjugates for biomedical applications |
US6186628B1 (en) | 1999-05-23 | 2001-02-13 | Jozek F. Van de Velde | Scanning laser ophthalmoscope for selective therapeutic laser |
WO2001008552A1 (en) | 1999-08-03 | 2001-02-08 | Biophysica, Llc | Spectroscopic systems and methods for detecting tissue properties |
US6944493B2 (en) | 1999-09-10 | 2005-09-13 | Akora, Inc. | Indocyanine green (ICG) compositions and related methods of use |
US6351663B1 (en) | 1999-09-10 | 2002-02-26 | Akorn, Inc. | Methods for diagnosing and treating conditions associated with abnormal vasculature using fluorescent dye angiography and dye-enhanced photocoagulation |
AU7106400A (en) | 1999-09-10 | 2001-04-10 | Akorn, Inc. | Fluorescent dye angiography and dye-enhanced photocoagulation |
US6915154B1 (en) | 1999-09-24 | 2005-07-05 | National Research Council Of Canada | Method and apparatus for performing intra-operative angiography |
DE60036781T2 (de) | 1999-09-24 | 2008-07-24 | National Research Council Of Canada, Ottawa | Vorrichtung zur durchführung von intra-operativer angiographie |
US20050182434A1 (en) | 2000-08-11 | 2005-08-18 | National Research Council Of Canada | Method and apparatus for performing intra-operative angiography |
US7581191B2 (en) | 1999-11-15 | 2009-08-25 | Xenogen Corporation | Graphical user interface for 3-D in-vivo imaging |
JP2001147387A (ja) | 1999-11-22 | 2001-05-29 | Asahi Optical Co Ltd | 走査光学装置 |
AU1547101A (en) | 1999-11-26 | 2001-06-04 | Applied Spectral Imaging Ltd. | System and method for functional brain mapping and an oxygen saturation difference map algorithm for effecting same |
US6443976B1 (en) | 1999-11-30 | 2002-09-03 | Akorn, Inc. | Methods for treating conditions and illnesses associated with abnormal vasculature |
AT409451B (de) | 1999-12-14 | 2002-08-26 | Hoffmann La Roche | Vorrichtung zur bestimmung der örtlichen verteilung einer messgrösse |
US6319273B1 (en) | 1999-12-16 | 2001-11-20 | Light Sciences Corporation | Illuminating device for treating eye disease |
US6603552B1 (en) | 1999-12-22 | 2003-08-05 | Xillix Technologies Corp. | Portable system for detecting skin abnormalities based on characteristic autofluorescence |
AUPQ514600A0 (en) | 2000-01-18 | 2000-02-10 | James Cook University | Brain injury treatment |
US6447443B1 (en) | 2001-01-13 | 2002-09-10 | Medtronic, Inc. | Method for organ positioning and stabilization |
JP2001198079A (ja) * | 2000-01-19 | 2001-07-24 | Fuji Photo Film Co Ltd | 蛍光診断装置 |
JP2003527604A (ja) | 2000-03-10 | 2003-09-16 | ワシントン・ユニバーシティ | 個々の細胞の標識方法 |
JP2001299676A (ja) | 2000-04-25 | 2001-10-30 | Fuji Photo Film Co Ltd | センチネルリンパ節検出方法および検出システム |
GB0010123D0 (en) | 2000-04-27 | 2000-06-14 | Univ Nottingham | Planar light sheet anemometers |
AU2001259435A1 (en) | 2000-05-03 | 2001-11-12 | Stephen T Flock | Optical imaging of subsurface anatomical structures and biomolecules |
GB0011278D0 (en) | 2000-05-10 | 2000-06-28 | Univ London | Repair of nerve damage |
DE10028233A1 (de) | 2000-06-07 | 2002-01-24 | Cobra Electronic Gmbh | Farbkameraanordnung mit einem photosensitiven,Iv ladungsgekoppelten Bildwandler (CCD) |
US7482318B2 (en) | 2000-07-26 | 2009-01-27 | University Of Maryland, Baltimore | Protein kinase domain of the large subunit of herpes simplex type 2 ribonucleotide reductase (icp 10pk) has anti-apoptotic activity |
US6669926B1 (en) | 2000-10-16 | 2003-12-30 | Mallinckrodt, Inc. | Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients |
US6869437B1 (en) | 2000-11-13 | 2005-03-22 | Cardica, Inc. | Method and system for performing closed-chest bypass |
DE10059070C1 (de) | 2000-11-28 | 2002-02-14 | Pulsion Medical Sys Ag | Vorrichtung zur Bestimmung von Gewebeperfusion und intraoperative Verwendung |
DE60236068D1 (de) | 2001-01-31 | 2010-06-02 | Mayo Foundation | Nachweis von herpex-simplex-virus |
US20020181752A1 (en) | 2001-03-14 | 2002-12-05 | Warren Wallo | Method for measuring changes in portions of a human body |
US7225011B2 (en) | 2001-04-02 | 2007-05-29 | Koninklijke Philips Electronics, N.V. | Heart modeling using a template |
US20030064025A1 (en) | 2001-04-05 | 2003-04-03 | Xiaoming Yang | Imaging systems for in vivo protocols |
DE10120980B4 (de) | 2001-05-01 | 2009-12-03 | Pulsion Medical Systems Ag | Verfahren, Vorrichtung und Computerprogramm zur Bestimmung des Blutflusses in einer Gewebe- oder Organregion |
US6757554B2 (en) | 2001-05-22 | 2004-06-29 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution |
US6582079B2 (en) | 2001-06-05 | 2003-06-24 | Metrologic Instruments, Inc. | Modular adaptive optical subsystem for integration with a fundus camera body and CCD camera unit and improved fundus camera employing same |
EP1406081A4 (en) | 2001-07-03 | 2011-10-05 | Hitachi Ltd | METHOD FOR OPTICALLY MEASURING BIOLOGICAL SAMPLING AND OPTICAL MEASURING APPARATUS FOR BIOLOGICAL SAMPLING |
WO2003006658A1 (en) | 2001-07-13 | 2003-01-23 | The General Hospital Corporation | Mutant herpes simplex virus that expresses yeast cytosine deaminase |
US6544183B2 (en) | 2001-08-02 | 2003-04-08 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Method for imaging skin surface intercellular and intracellular structure using a compound to enhance contrast |
DE10143995A1 (de) | 2001-09-07 | 2003-04-03 | Pulsion Medical Sys Ag | System und Computerprogramm zur Bestimmung von Kreislaufgrößen eines Patienten |
US7113817B1 (en) | 2001-10-04 | 2006-09-26 | Wintec, Llc | Optical imaging of blood circulation velocities |
US6886565B2 (en) | 2001-10-19 | 2005-05-03 | Innovative Retinal Products Llc | Macula cover and method |
US6942655B2 (en) | 2001-11-13 | 2005-09-13 | Minu, Llc | Method to treat age-related macular degeneration |
US6936043B2 (en) | 2001-11-13 | 2005-08-30 | Minu, Llc | Method to treat age-related macular degeneration |
JP3753650B2 (ja) | 2001-11-14 | 2006-03-08 | 株式会社島津製作所 | 血流測定装置 |
SE0103827D0 (sv) | 2001-11-16 | 2001-11-16 | Mikael Wiberg | Nerve repair unit and method of producing it |
JP3820979B2 (ja) | 2001-12-17 | 2006-09-13 | ブラザー工業株式会社 | パッチ形成装置およびプログラム |
US6899675B2 (en) | 2002-01-15 | 2005-05-31 | Xillix Technologies Corp. | Fluorescence endoscopy video systems with no moving parts in the camera |
EP1332718A1 (en) | 2002-02-01 | 2003-08-06 | Stichting Voor De Technische Wetenschappen | Laser doppler perfusion imaging using a CMOS image sensor |
DE60332320D1 (de) | 2002-02-14 | 2010-06-10 | Takeda Pharmaceutical | Neues screening-verfahren |
ES2406697T3 (es) | 2002-03-12 | 2013-06-07 | Beth Israel Deaconess Medical Center | Sistema de obtención de imágenes médicas |
US20030187349A1 (en) | 2002-03-29 | 2003-10-02 | Olympus Optical Co., Ltd. | Sentinel lymph node detecting method |
US20030232016A1 (en) | 2002-04-17 | 2003-12-18 | Russell Heinrich | Nerve identification and sparing method |
US7404640B2 (en) | 2002-06-14 | 2008-07-29 | Physical Sciences, Inc. | Monitoring blood flow in the retina using a line-scanning laser ophthalmoscope |
JP4515721B2 (ja) | 2002-06-21 | 2010-08-04 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 灌流画像を分析するための方法、装置及びソフトウェア |
US20060134001A1 (en) | 2002-07-12 | 2006-06-22 | Frangioni John V | Conjugated infrared fluorescent substances for detection of cell death |
US7364574B2 (en) | 2002-07-17 | 2008-04-29 | Novadaq Technologies Inc. | Combined photocoagulation and photodynamic therapy |
US7897336B2 (en) | 2002-08-16 | 2011-03-01 | John Wayne Cancer Institute | Molecular lymphatic mapping of sentinel lymph nodes |
DE10362402B3 (de) | 2002-08-28 | 2022-03-03 | Carl Zeiss Meditec Ag | Mikroskopiesystem und Mikroskopieverfahren |
US20040077952A1 (en) | 2002-10-21 | 2004-04-22 | Rafter Patrick G. | System and method for improved diagnostic image displays |
US7005518B2 (en) | 2002-10-25 | 2006-02-28 | Li-Cor, Inc. | Phthalocyanine dyes |
EP1592336B1 (en) | 2002-12-02 | 2012-08-22 | Yeda Research And Development Co., Ltd. | Characterization of arteriosclerosis by optical imaging |
DE10257743B4 (de) | 2002-12-10 | 2006-11-23 | Irmgard Zerrle | Vorrichtung zur Bestimmung der Perfusion in einem Gewebebereich und des Blutflusses durch einzelne Blutgefäße |
US20040156782A1 (en) | 2003-02-12 | 2004-08-12 | Akorn, Inc. | Methods of using indocyanine green (ICG) dye |
JP2004325200A (ja) * | 2003-04-24 | 2004-11-18 | Hitachi Ltd | 組織内物質濃度測定装置 |
WO2005002425A2 (en) | 2003-07-02 | 2005-01-13 | U.S. Government As Represented By The Secretary Of The Army | Wearable tissue viability diagnostic unit |
US20050019744A1 (en) | 2003-07-25 | 2005-01-27 | La Jolla Bioengineering Institute | Ultrasound-assisted ischemic reperfusion |
WO2005026319A2 (en) | 2003-08-06 | 2005-03-24 | The Regents Of Teh University Of California | Erythrocytic cells and method for loading solutes |
WO2005034747A1 (en) | 2003-09-15 | 2005-04-21 | Beth Israel Deaconess Medical Center | Medical imaging systems |
EP1677097A4 (en) | 2003-10-10 | 2010-09-01 | Hamamatsu Photonics Kk | METHOD AND SYSTEM FOR DETERMINING THE CONCENTRATION OF A FLUORESCENT PIGMENT |
US7512436B2 (en) | 2004-02-12 | 2009-03-31 | The Regents Of The University Of Michigan | Method of evaluating metabolism of the eye |
WO2006014334A2 (en) | 2004-07-06 | 2006-02-09 | Advanced Biophotonics, Inc. | Systems and methods for localizing vascular architecture, and evaluation and monitoring of functional behavior of same |
US7381400B2 (en) | 2004-07-13 | 2008-06-03 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Injection of a radioactive dye for sentinel lymph node identification |
US7394053B2 (en) | 2004-09-09 | 2008-07-01 | Beth Israel Deaconess Medical Center, Inc. | Systems and methods for multi-modal imaging having a spatial relationship in three dimensions between first and second image data |
US7899271B1 (en) | 2004-09-15 | 2011-03-01 | Raytheon Company | System and method of moving target based calibration of non-uniformity compensation for optical imagers |
WO2006062895A2 (en) * | 2004-12-06 | 2006-06-15 | Cambridge Research And Instrumentation, Inc. | Systems and methods for in-vivo optical imaging and measurement |
JP5028008B2 (ja) | 2004-12-08 | 2012-09-19 | オリンパス株式会社 | 蛍光内視鏡装置 |
JP4937991B2 (ja) * | 2004-12-08 | 2012-05-23 | オリンパス株式会社 | 蛍光内視鏡装置及びそれに用いる撮像ユニット |
CA2634466A1 (en) | 2004-12-22 | 2006-06-29 | Bio-Tree Systems, Inc. | Medical imaging methods and apparatus for diagnosis and monitoring of diseases and uses therefor |
US7729750B2 (en) | 2005-01-20 | 2010-06-01 | The Regents Of The University Of California | Method and apparatus for high resolution spatially modulated fluorescence imaging and tomography |
FR2882147B1 (fr) * | 2005-02-14 | 2007-10-05 | Commissariat Energie Atomique | Dispositif d'imagerie de fluorescence par reflexion a deux longueurs d'onde |
DE202005003411U1 (de) | 2005-02-24 | 2006-07-06 | Karl Storz Gmbh & Co. Kg | Multifunktionales Fluoreszenzdiagnosesystem |
AU2006234326B2 (en) | 2005-04-14 | 2011-06-16 | Bracco Suisse S.A. | Perfusion assessment based on animated perfusion imaging |
US20130296715A1 (en) | 2005-04-20 | 2013-11-07 | Ecole Polytechnique Federale De Lausanne (Epfl) | Instrument and method for high-speed perfusion imaging |
WO2006111909A1 (en) | 2005-04-20 | 2006-10-26 | Cvl Cosmetics S.A. | Instrument and method for high-speed perfusion imaging |
WO2006116634A2 (en) | 2005-04-26 | 2006-11-02 | Novadaq Technologies, Inc. | Method and apparatus for vasculature visualization with applications in neurosurgery and neurology |
US20060239921A1 (en) | 2005-04-26 | 2006-10-26 | Novadaq Technologies Inc. | Real time vascular imaging during solid organ transplant |
RU2288633C1 (ru) | 2005-04-29 | 2006-12-10 | ГОУ ВПО "Красноярская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" | Способ определения границ резекции при закрытой травме поджелудочной железы с разрывом главного панкреатического протока |
EP1883354A2 (en) | 2005-04-29 | 2008-02-06 | Novadaq Technologies Inc. | Choroid and retinal imaging and treatment system |
EP1884197B1 (en) | 2005-05-20 | 2013-01-02 | Hitachi Medical Corporation | Image diagnosing device |
US7400755B2 (en) | 2005-06-02 | 2008-07-15 | Accuray Incorporated | Inverse planning using optimization constraints derived from image intensity |
JP2007021006A (ja) | 2005-07-20 | 2007-02-01 | Hitachi Medical Corp | X線ct装置 |
WO2007016790A1 (en) | 2005-08-10 | 2007-02-15 | Novadaq Technologies, Inc. | Intra-operative head & neck nerve mapping |
US20070122344A1 (en) | 2005-09-02 | 2007-05-31 | University Of Rochester Medical Center Office Of Technology Transfer | Intraoperative determination of nerve location |
DE102005044531A1 (de) | 2005-09-16 | 2007-03-22 | Myrenne Gmbh | Verfahren zur Bestimmung einer Perfusionsverteilung |
EP1962688B1 (en) | 2005-12-15 | 2012-05-16 | Koninklijke Philips Electronics N.V. | A method and an apparatus for determining a degree of pulsatility in angiography |
WO2007122602A1 (en) | 2006-04-26 | 2007-11-01 | Seng Enterprises Ltd. | A method and system for measuring membrane potential based on fluorescence polarization |
DE102006025423A1 (de) | 2006-05-31 | 2007-12-06 | Siemens Ag | Röntgenanlage mit dual energy Betrieb und Auswertungsverfahren für im dual energy Betrieb erfasste Projektionsbilder |
EP2034890A4 (en) * | 2006-06-01 | 2011-02-16 | Gen Hospital Corp | IN VIVO OPTICAL IMAGING METHOD COMPRISING THE ANALYSIS OF DYNAMIC IMAGES |
CA2692923A1 (en) | 2006-07-03 | 2008-06-26 | Beth Israel Deaconess Medical Center, Inc. | Intraoperative imaging methods |
WO2008005991A1 (en) | 2006-07-03 | 2008-01-10 | Beth Israel Deaconess Medical Center, Inc. | Invisible light fluorescent platelets for intraoperative detection of vascular thrombosis |
US7450243B2 (en) | 2006-07-10 | 2008-11-11 | The Board Of Trustees Of The University Of Illinois | Volumetric endoscopic coherence microscopy using a coherent fiber bundle |
US9089601B2 (en) | 2006-07-10 | 2015-07-28 | University Of Rochester | Pre- and intra-operative imaging of bladder cancer |
US8078265B2 (en) | 2006-07-11 | 2011-12-13 | The General Hospital Corporation | Systems and methods for generating fluorescent light images |
JP4936812B2 (ja) | 2006-07-21 | 2012-05-23 | 株式会社日本色材工業研究所 | 化粧料の成型装置および成型方法 |
US8725225B2 (en) | 2006-08-10 | 2014-05-13 | University Of Rochester | Intraoperative imaging of renal cortical tumors and cysts |
US20080161744A1 (en) | 2006-09-07 | 2008-07-03 | University Of Rochester Medical Center | Pre-And Intra-Operative Localization of Penile Sentinel Nodes |
US20080081990A1 (en) | 2006-09-28 | 2008-04-03 | The Research Foundation Of State University Of New York | Apparatus, system, kit and method for heart mapping |
WO2008070269A2 (en) | 2006-10-06 | 2008-06-12 | Novadaq Technologies, Inc. | Methods, software and systems for imaging |
KR100867977B1 (ko) | 2006-10-11 | 2008-11-10 | 한국과학기술원 | 인도시아닌 그린 혈중 농도 역학을 이용한 조직 관류 분석장치 및 그를 이용한 조직 관류 분석방법 |
US8498695B2 (en) * | 2006-12-22 | 2013-07-30 | Novadaq Technologies Inc. | Imaging system with a single color image sensor for simultaneous fluorescence and color video endoscopy |
JP4954699B2 (ja) * | 2006-12-28 | 2012-06-20 | オリンパス株式会社 | 蛍光内視鏡システム |
JP5489469B2 (ja) | 2007-01-16 | 2014-05-14 | オリンパス株式会社 | 蛍光信号解析装置および蛍光信号解析方法 |
KR100818669B1 (ko) | 2007-03-09 | 2008-04-02 | 한국과학기술원 | 하지 관류정도 측정장치 |
DE102007014133B4 (de) | 2007-03-23 | 2015-10-29 | Siemens Aktiengesellschaft | Verfahren zur Visualisierung einer Sequenz tomographischer Volumendatensätze der medizinischen Bildgebung |
CN101641045B (zh) | 2007-03-23 | 2012-08-22 | 安维尔蒂斯股份有限公司 | 用于确定微血管损伤的装置 |
DE102007018641B8 (de) | 2007-04-19 | 2009-10-08 | Carl Zeiss Surgical Gmbh | Navigationssystem für Gehirnoperationen |
CN101784227B (zh) | 2007-07-06 | 2013-12-04 | 工业研究有限公司 | 激光散斑成像***和方法 |
US8073224B2 (en) | 2007-07-09 | 2011-12-06 | Siemens Aktiengesellschaft | System and method for two-dimensional visualization of temporal phenomena and three dimensional vessel reconstruction |
DE102007048362B9 (de) | 2007-10-09 | 2017-08-17 | Carl Zeiss Meditec Ag | System und Verfahren zum Untersuchen eines Objekts |
AU2009204461A1 (en) | 2008-01-10 | 2009-07-16 | Pacific Biosciences Of California, Inc. | Methods and systems for analysis of fluorescent reactions with modulated excitation |
US8406860B2 (en) | 2008-01-25 | 2013-03-26 | Novadaq Technologies Inc. | Method for evaluating blush in myocardial tissue |
CA2750760C (en) | 2008-01-25 | 2019-11-19 | Novadaq Technologies Inc. | Method for evaluating blush in myocardial tissue |
US20140316262A1 (en) | 2008-02-26 | 2014-10-23 | Novadaq Technologies Inc. | Preoperative identification of perforator vessels in flaps to be used in reconstructive surgery |
RU2510235C2 (ru) | 2008-03-18 | 2014-03-27 | Новадак Текнолоджиз Инк. | Система визуализации для получения комбинированного изображения из полноцветного изображения в отраженном свете и изображение в ближней инфракрасной области |
JP5074256B2 (ja) * | 2008-03-24 | 2012-11-14 | オリンパス株式会社 | 蛍光観察装置 |
JP5918532B2 (ja) | 2008-04-14 | 2016-05-18 | ノバダック テクノロジーズ インコーポレイテッド | 穿通枝血管の灌流を評価する装置及び穿通枝血管の灌流を評価するための装置の作動制御方法 |
ES2671710T3 (es) | 2008-05-02 | 2018-06-08 | Novadaq Technologies ULC | Métodos para la producción y uso de eritrocitos cargados con sustancias para la observación y el tratamiento de la hemodinámica microvascular |
US8150127B2 (en) | 2008-05-28 | 2012-04-03 | Siemens Medical Solutions Usa, Inc. | Method for automatically synchronizing the review of two DSA scenes |
JP5389382B2 (ja) * | 2008-06-09 | 2014-01-15 | オリンパス株式会社 | 蛍光内視鏡装置 |
DE102008040804B4 (de) | 2008-07-28 | 2021-07-29 | Carl Zeiss Meditec Ag | Verfahren, Operationsmikroskop und Analysesystem zur quantitativen Darstellung des Blutflusses |
DE102008040803A1 (de) | 2008-07-28 | 2010-02-04 | Carl Zeiss Surgical Gmbh | Verfahren zur quantitativen Darstellung des Blutflusses |
US8144958B2 (en) | 2008-09-11 | 2012-03-27 | Carl Zeiss Meditec Ag | Medical systems and methods |
CN101451953B (zh) * | 2008-12-31 | 2011-03-30 | 聚光科技(杭州)股份有限公司 | 一种生物毒性的检测方法 |
EP2383564A1 (en) * | 2009-01-09 | 2011-11-02 | Mitsui Engineering & Shipbuilding Co., Ltd. | Fluorescence detecting device and fluorescence detecting method |
US10316000B2 (en) | 2009-02-18 | 2019-06-11 | Cornell University | Coupled recognition/detection system for in vivo and in vitro use |
US10492671B2 (en) | 2009-05-08 | 2019-12-03 | Novadaq Technologies ULC | Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest |
FR2944104A1 (fr) * | 2009-08-25 | 2010-10-08 | Commissariat Energie Atomique | Extinction de l'autofluorescence des tissus biologiques en tomographie resolue en temps |
US20110071403A1 (en) | 2009-09-21 | 2011-03-24 | Board Of Regents Of The University Of Texas System | Functional near-infrared fluorescence lymphatic mapping for diagnosing, accessing, monitoring and directing therapy of lymphatic disorders |
US9091903B2 (en) | 2010-07-29 | 2015-07-28 | Logitech Europe S.A. | Optimized movable IR filter in cameras |
JP5682975B2 (ja) * | 2010-09-02 | 2015-03-11 | 国立大学法人東北大学 | がん発症又はがん発症リスクの判定方法 |
US20130230866A1 (en) * | 2010-09-17 | 2013-09-05 | Tohoku University | Method for Determining Effectiveness of Medicine Containing Antibody as Component |
JP5371946B2 (ja) * | 2010-12-24 | 2013-12-18 | 富士フイルム株式会社 | 内視鏡診断装置 |
US9226673B2 (en) | 2011-01-10 | 2016-01-05 | East Carolina University | Methods, systems and computer program products for non-invasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling |
EP2663222B1 (en) | 2011-01-10 | 2021-10-27 | East Carolina University | Methods and systems for non-invasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling |
US9179843B2 (en) | 2011-04-21 | 2015-11-10 | Hassan Ghaderi MOGHADDAM | Method and system for optically evaluating proximity to the inferior alveolar nerve in situ |
CN102288589B (zh) * | 2011-06-23 | 2013-05-08 | 深圳大学 | 单个荧光探针的定位方法、装置及超分辨成像方法、*** |
EP2728344A4 (en) * | 2011-06-29 | 2015-04-08 | Kyoto Prefectural Public Univ Corp | DEVICE AND METHOD FOR IDENTIFYING THE SITE OF A TUMOR |
CN102436648B (zh) * | 2011-08-11 | 2014-01-01 | 上海交通大学 | 基于背景荧光消除的目标荧光光谱解混方法 |
KR101325054B1 (ko) * | 2011-10-19 | 2013-11-20 | 유인성 | 형광 영상을 촬영하는 장치 및 방법 |
EP2863801B8 (en) | 2012-06-21 | 2024-06-12 | Stryker Corporation | Quantification and analysis of angiography and perfusion |
US9575304B2 (en) * | 2012-06-25 | 2017-02-21 | Huron Technologies International Inc. | Pathology slide scanners for fluorescence and brightfield imaging and method of operation |
US9449377B2 (en) * | 2012-10-09 | 2016-09-20 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Imaging methods and computer-readable media |
JP6198426B2 (ja) * | 2013-03-29 | 2017-09-20 | 浜松ホトニクス株式会社 | 蛍光観察装置及び蛍光観察方法 |
US10285603B2 (en) | 2013-06-14 | 2019-05-14 | Novadaq Technologies ULC | Quantification of absolute blood flow in tissue using fluorescence mediated photoplethysmography |
WO2015002082A1 (ja) * | 2013-07-03 | 2015-01-08 | コニカミノルタ株式会社 | 画像処理装置、病理診断支援システム、画像処理プログラム及び病理診断支援方法 |
JP5981052B2 (ja) * | 2014-06-05 | 2016-08-31 | オリンパス株式会社 | 処理装置、内視鏡システム、内視鏡装置、画像処理装置の作動方法および画像処理プログラム |
WO2016049756A1 (en) * | 2014-09-29 | 2016-04-07 | Novadaq Technologies Inc. | Imaging a target fluorophore in a biological material in the presence of autofluorescence |
JP6487544B2 (ja) | 2014-10-09 | 2019-03-20 | ノバダック テクノロジーズ ユーエルシー | 蛍光媒介光電式容積脈波記録法を用いた組織中の絶対血流の定量化 |
EP4242743A3 (en) | 2017-02-10 | 2023-10-18 | Stryker European Operations Limited | Open-field handheld fluorescence imaging systems and methods |
-
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- 2017-10-31 US US15/799,727 patent/US10488340B2/en active Active
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- 2018-03-23 HK HK18104021.5A patent/HK1244873A1/zh unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1678239A (zh) * | 2002-08-01 | 2005-10-05 | 约翰霍普金斯大学 | 利用荧光鉴定分子结构和使体腔起皱的细胞类型的技术 |
CN1636506A (zh) * | 2003-12-12 | 2005-07-13 | 强生消费者公司 | 评估皮肤与个体之整体健康的方法 |
WO2007012301A1 (de) * | 2005-07-29 | 2007-02-01 | Biocam Gmbh | Verfahren sowie messsystem zur ermittlung der sauerstoffpartialdruckverteilung in zumindest einem gewebeflächenabschnitt, insbesondere hautgewebeflächenabschnitt |
CN101484067A (zh) * | 2006-07-07 | 2009-07-15 | 皇家飞利浦电子股份有限公司 | 光学成像***和方法 |
CN102026668A (zh) * | 2008-05-14 | 2011-04-20 | 诺瓦达克技术公司 | 用于神经成像的包括与病毒组分结合的荧光染料的成像法和组合物 |
WO2012038824A1 (en) * | 2010-09-20 | 2012-03-29 | Novadaq Technologies Inc. | Locating and analyzing perforator flaps for plastic and reconstructive surgery |
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WO2016049756A1 (en) | 2016-04-07 |
US20160110870A1 (en) | 2016-04-21 |
KR20190122890A (ko) | 2019-10-30 |
AU2015327665A1 (en) | 2017-04-13 |
HK1244873A1 (zh) | 2018-08-17 |
CA2963987A1 (en) | 2016-04-07 |
US20180120230A1 (en) | 2018-05-03 |
KR20170067803A (ko) | 2017-06-16 |
US9816930B2 (en) | 2017-11-14 |
EP3201607A4 (en) | 2018-08-15 |
CN107209118A (zh) | 2017-09-26 |
EP3201607A1 (en) | 2017-08-09 |
AU2015327665B2 (en) | 2018-09-27 |
US10488340B2 (en) | 2019-11-26 |
EP3201607B1 (en) | 2020-12-30 |
JP6549705B2 (ja) | 2019-07-24 |
KR102068776B1 (ko) | 2020-01-21 |
JP2017533415A (ja) | 2017-11-09 |
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