JP5918532B2 - 穿通枝血管の灌流を評価する装置及び穿通枝血管の灌流を評価するための装置の作動制御方法 - Google Patents
穿通枝血管の灌流を評価する装置及び穿通枝血管の灌流を評価するための装置の作動制御方法 Download PDFInfo
- Publication number
- JP5918532B2 JP5918532B2 JP2011504574A JP2011504574A JP5918532B2 JP 5918532 B2 JP5918532 B2 JP 5918532B2 JP 2011504574 A JP2011504574 A JP 2011504574A JP 2011504574 A JP2011504574 A JP 2011504574A JP 5918532 B2 JP5918532 B2 JP 5918532B2
- Authority
- JP
- Japan
- Prior art keywords
- intensity
- time
- image
- transfer function
- perfusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000000149 penetrating effect Effects 0.000 title claims description 34
- 238000000034 method Methods 0.000 title claims description 20
- 230000010412 perfusion Effects 0.000 title claims description 13
- 210000004204 blood vessel Anatomy 0.000 title claims description 5
- 238000012545 processing Methods 0.000 claims description 20
- 238000012546 transfer Methods 0.000 claims description 19
- 230000004044 response Effects 0.000 claims description 5
- 230000002123 temporal effect Effects 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 239000003086 colorant Substances 0.000 claims description 3
- 238000012886 linear function Methods 0.000 claims 3
- 210000002816 gill Anatomy 0.000 claims 2
- 238000012935 Averaging Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 33
- 229960004657 indocyanine green Drugs 0.000 description 33
- 210000003491 skin Anatomy 0.000 description 21
- 230000006870 function Effects 0.000 description 16
- 210000001519 tissue Anatomy 0.000 description 14
- 238000002073 fluorescence micrograph Methods 0.000 description 12
- 238000011156 evaluation Methods 0.000 description 7
- 230000005284 excitation Effects 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 210000003484 anatomy Anatomy 0.000 description 4
- 238000003384 imaging method Methods 0.000 description 4
- 238000013507 mapping Methods 0.000 description 4
- 230000003595 spectral effect Effects 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 230000000007 visual effect Effects 0.000 description 4
- 238000013459 approach Methods 0.000 description 3
- 238000002316 cosmetic surgery Methods 0.000 description 3
- 210000004207 dermis Anatomy 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000003815 abdominal wall Anatomy 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000002583 angiography Methods 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000036770 blood supply Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000010968 computed tomography angiography Methods 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 230000004807 localization Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000002278 reconstructive surgery Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010060872 Transplant failure Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003872 anastomosis Effects 0.000 description 1
- 230000008321 arterial blood flow Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 238000012632 fluorescent imaging Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 210000001139 rectus abdominis Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 238000012731 temporal analysis Methods 0.000 description 1
- 238000000700 time series analysis Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000009724 venous congestion Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0265—Measuring blood flow using electromagnetic means, e.g. electromagnetic flowmeter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0275—Measuring blood flow using tracers, e.g. dye dilution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4887—Locating particular structures in or on the body
- A61B5/489—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7239—Details of waveform analysis using differentiation including higher order derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7242—Details of waveform analysis using integration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2576/00—Medical imaging apparatus involving image processing or analysis
- A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/74—Details of notification to user or communication with user or patient ; user input means
- A61B5/742—Details of notification to user or communication with user or patient ; user input means using visual displays
- A61B5/7425—Displaying combinations of multiple images regardless of image source, e.g. displaying a reference anatomical image with a live image
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/74—Details of notification to user or communication with user or patient ; user input means
- A61B5/742—Details of notification to user or communication with user or patient ; user input means using visual displays
- A61B5/743—Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H30/00—ICT specially adapted for the handling or processing of medical images
- G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Physiology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Signal Processing (AREA)
- Psychiatry (AREA)
- Artificial Intelligence (AREA)
- Electromagnetism (AREA)
- Vascular Medicine (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Prostheses (AREA)
- Surgical Instruments (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Eye Examination Apparatus (AREA)
Description
本出願は、2008年4月14日出願の米国特許仮出願第61/044,779号の優先権を主張するものであり、その全内容を参照により本明細書に組み込む。
1)ICG結合血液が組織中に存在する量。
2)ICG結合血液が組織中に存在する時間。
3)ICG結合血液が組織中を移動する速度。
4)ボーラス注入後、解剖学的領域が発光する順序。
時間積分蛍光を経過時間で除算して、平均蛍光を計算すること。
蛍光の増大/流出率を求めること。
ピーク蛍光に達する経過時間を求めること。
吻合開通、ならびに動脈流および静脈流の確認。これは、潜在的に皮弁不全をなくす結果を向上させ得るものであり、皮弁不全は、動脈流が低下し、灌流(perfusion)が不十分となり、静脈還流もやはり低下して、鬱血が生じる結果として生じる可能性がある。
1)画像シーケンス中の全画像の全ピクセルについて、積算強度を時間窓にわたって計算する。
2)積算強度を、選択したラベルの領域(例えば、5×5ピクセル正方行列)にわたって平均する。
3)平均強度を、全画像の積算強度の最大値に正規化する。
4)正規化した平均を、伝達関数の最大値が100%を表すようにスケーリングする。
Claims (6)
- 穿通枝血管の灌流を評価するための装置の作動制御方法であって、
検出手段が、ICGボーラスが血流に加えられた組織からの蛍光応答を検出するステップと、
取得する手段が、所定の時間にわたって前記蛍光応答の時間的な画像シーケンスを取得するステップと、
選択する手段が、前記画像シーケンスを処理するためのアルゴリズムを選択するステップと、
画像を処理する手段が、前記選択したアルゴリズムを用いて、前記画像のピクセル値の時間積分強度または強度の時間微分を算出するように、前記画像シーケンスを処理するステップと、
表示する手段が、前記時間積分強度または強度の時間微分を、カラー画像として表示するステップと、
適用する手段が、コントラスト伝達関数を前記時間積分強度または前記強度の時間微分に適用するステップとを含み、
前記コントラスト伝達関数は、前記時間積分強度または前記強度の時間微分を、異なる灌流特性を異なる色で表すオーバーレイ画像に変換する線形関数または非線形関数を表すことを特徴とする方法。 - 前記時間的な画像シーケンスは、各ピクセルの前記時間積分強度値を、ICGボーラス注入後の経過時間で除算することによって処理されることを特徴とする請求項1に記載の方法。
- 前記コントラスト伝達関数は、異なる傾きの領域を有する非線形関数であり、前記傾きと、前記異なる傾き間の移行とを前記血管の前記灌流を評価する手順の間、臨床医によって選択することができることを特徴とする請求項1乃至2のいずれか一項に記載の方法。
- 前記時間積分強度または前記強度の時間微分の数値を、前記オーバーレイ画像で表示するステップをさらに含むことを特徴とする請求項1乃至3のいずれか一項に記載の方法。
- 1つ以上の選択された画像領域について、時間積分強度比率を計算するステップをさらに含み、
前記時間積分強度比率は、
全ピクセルについて前記時間積分強度を計算するステップと、
前記時間積分強度を、前記選択された画像領域にわたって平均するステップと、
前記平均された時間積分強度を、全画像の前記時間積分強度の最大値に正規化するステップと、
前記正規化された強度を、前記コントラスト伝達関数の前記最大値を用いてスケーリングするステップと、
を用いて計算されることを特徴とする請求項1乃至4のいずれか一項に記載の方法。 - 穿通枝血管の灌流を評価する装置であって、
ICGボーラスが血流に加えられた組織からの蛍光応答を検出する手段と、
所定の時間にわたって前記蛍光応答の時間的な画像シーケンスを取得する手段と、
前記画像シーケンスを処理するためのアルゴリズムを選択する手段と、
前記選択したアルゴリズムを用いて、前記画像のピクセル値の時間積分強度または強度の時間微分を算出するように、前記画像シーケンスを処理する手段と、
前記時間積分強度または前記強度の時間微分を、カラー画像として表示する手段と、
コントラスト伝達関数を前記時間積分強度または前記強度の時間微分に適用する手段とを備え、
前記コントラスト伝達関数は、前記時間積分強度または前記強度の時間微分を、異なる灌流特性を異なる色で表すオーバーレイ画像に変換する線形関数または非線形関数を表すことを特徴とする装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4477908P | 2008-04-14 | 2008-04-14 | |
US61/044,779 | 2008-04-14 | ||
PCT/IB2009/005700 WO2009127972A2 (en) | 2008-04-14 | 2009-04-14 | Locating and analyzing perforator flaps for plastic and reconstructive surgery |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016014503A Division JP6577877B2 (ja) | 2008-04-14 | 2016-01-28 | 組織灌流を評価するための方法及びシステム |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011519589A JP2011519589A (ja) | 2011-07-14 |
JP5918532B2 true JP5918532B2 (ja) | 2016-05-18 |
Family
ID=41199522
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011504574A Active JP5918532B2 (ja) | 2008-04-14 | 2009-04-14 | 穿通枝血管の灌流を評価する装置及び穿通枝血管の灌流を評価するための装置の作動制御方法 |
JP2016014503A Active JP6577877B2 (ja) | 2008-04-14 | 2016-01-28 | 組織灌流を評価するための方法及びシステム |
JP2019099701A Pending JP2019193798A (ja) | 2008-04-14 | 2019-05-28 | 形成外科および再建手術のための穿通枝皮弁の位置特定および分析 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016014503A Active JP6577877B2 (ja) | 2008-04-14 | 2016-01-28 | 組織灌流を評価するための方法及びシステム |
JP2019099701A Pending JP2019193798A (ja) | 2008-04-14 | 2019-05-28 | 形成外科および再建手術のための穿通枝皮弁の位置特定および分析 |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP2268201B1 (ja) |
JP (3) | JP5918532B2 (ja) |
KR (2) | KR101621107B1 (ja) |
CN (1) | CN102083362B (ja) |
BR (1) | BRPI0907272A2 (ja) |
HK (1) | HK1158482A1 (ja) |
MX (1) | MX2010011249A (ja) |
RU (1) | RU2506896C2 (ja) |
WO (1) | WO2009127972A2 (ja) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9816930B2 (en) | 2014-09-29 | 2017-11-14 | Novadaq Technologies Inc. | Imaging a target fluorophore in a biological material in the presence of autofluorescence |
US9936887B2 (en) | 2008-01-25 | 2018-04-10 | Novadaq Technologies ULC | Method for evaluating blush in myocardial tissue |
US10041042B2 (en) | 2008-05-02 | 2018-08-07 | Novadaq Technologies ULC | Methods for production and use of substance-loaded erythrocytes (S-IEs) for observation and treatment of microvascular hemodynamics |
US10219742B2 (en) | 2008-04-14 | 2019-03-05 | Novadaq Technologies ULC | Locating and analyzing perforator flaps for plastic and reconstructive surgery |
US10265419B2 (en) | 2005-09-02 | 2019-04-23 | Novadaq Technologies ULC | Intraoperative determination of nerve location |
US10278585B2 (en) | 2012-06-21 | 2019-05-07 | Novadaq Technologies ULC | Quantification and analysis of angiography and perfusion |
US10434190B2 (en) | 2006-09-07 | 2019-10-08 | Novadaq Technologies ULC | Pre-and-intra-operative localization of penile sentinel nodes |
US10492671B2 (en) | 2009-05-08 | 2019-12-03 | Novadaq Technologies ULC | Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest |
US10631746B2 (en) | 2014-10-09 | 2020-04-28 | Novadaq Technologies ULC | Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography |
US10992848B2 (en) | 2017-02-10 | 2021-04-27 | Novadaq Technologies ULC | Open-field handheld fluorescence imaging systems and methods |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102010018872A1 (de) * | 2010-04-30 | 2011-11-03 | Siemens Aktiengesellschaft | Bildgebendes Verfahren zur hervorgehobenen Darstellung von Gefäßen in einem Untersuchungsbereich eines Patienten und Medizinsystem zur Durchführung des Verfahrens |
CN102764124B (zh) * | 2012-07-09 | 2013-12-25 | 华东师范大学 | 一种基于磁共振成像对穿支皮瓣血管定位与测量的方法 |
US10426361B2 (en) | 2013-06-14 | 2019-10-01 | Novadaq Technologies ULC | Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography |
US11553844B2 (en) | 2014-10-14 | 2023-01-17 | East Carolina University | Methods, systems and computer program products for calculating MetaKG signals for regions having multiple sets of optical characteristics |
JP2017534378A (ja) | 2014-10-14 | 2017-11-24 | イースト カロライナ ユニバーシティ | 血流量及び灌流量のマルチスペクトル画像化によって得られる信号を使用して血行動態パラメータを決定する方法、システム、及びコンピュータプログラム製品 |
CN107405094A (zh) * | 2014-10-14 | 2017-11-28 | 东卡罗莱娜大学 | 用于使用成像技术来可视化解剖结构以及血流和灌注生理机能的方法、***和计算机程序产品 |
CN107530452A (zh) * | 2015-02-02 | 2018-01-02 | 诺瓦达克技术公司 | 用于表征受试者的组织的方法和*** |
US10390718B2 (en) | 2015-03-20 | 2019-08-27 | East Carolina University | Multi-spectral physiologic visualization (MSPV) using laser imaging methods and systems for blood flow and perfusion imaging and quantification in an endoscopic design |
US10058256B2 (en) | 2015-03-20 | 2018-08-28 | East Carolina University | Multi-spectral laser imaging (MSLI) methods and systems for blood flow and perfusion imaging and quantification |
ES2798759T3 (es) * | 2015-07-06 | 2020-12-14 | Scinovia Corp | Formación de imágenes de flujo y mediciones basadas en fluorescencia |
US10026159B2 (en) * | 2015-09-23 | 2018-07-17 | Novadaq Technologies ULC | Methods and system for management of data derived from medical imaging |
WO2017051230A1 (en) * | 2015-09-23 | 2017-03-30 | Novadaq Technologies Inc. | Methods and systems for assessing healing of tissue |
EP3416547A4 (en) | 2016-02-16 | 2019-08-14 | Novadaq Technologies ULC | FACILITATION OF EVALUATION OF BLOOD FLOW AND TISSUE PERFUSION BY FLUORESCENCE-MEDIATED PHOTOPLETHYSMOGRAPHY |
CN109843176A (zh) | 2016-07-29 | 2019-06-04 | 诺瓦达克技术有限公司 | 用于利用机器学习来表征受验者的组织的方法和*** |
EP3651118B1 (en) * | 2017-06-01 | 2021-09-08 | Leica Instruments (Singapore) Pte. Ltd. | Method, image processor and device for observing an object containing a bolus of a fluorophore |
WO2019081833A1 (fr) | 2017-10-26 | 2019-05-02 | Fluoptics | Procédé et dispositif de suivi de la fluorescence émise à la surface d'un tissu biologique |
JP7200755B2 (ja) * | 2019-03-04 | 2023-01-10 | 株式会社島津製作所 | イメージング装置およびイメージング装置の作動方法 |
KR102446153B1 (ko) | 2019-07-31 | 2022-09-23 | 가톨릭대학교 산학협력단 | 피부 부착형 유리피판 혈류 모니터링 시스템 |
CN111358553B (zh) * | 2020-03-11 | 2021-08-10 | 宁波市第一医院 | 一种穿支皮瓣构建方法、装置、计算机设备及可存储介质 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3906860A1 (de) * | 1988-03-08 | 1989-09-28 | Fraunhofer Ges Forschung | Vorrichtung zum herstellen einer angiographie |
JPH09308609A (ja) * | 1996-05-24 | 1997-12-02 | Canon Inc | 眼科用画像処理装置 |
US6086539A (en) * | 1996-12-04 | 2000-07-11 | Acuson Corporation | Methods and apparatus for ultrasound image quantification |
US6915154B1 (en) * | 1999-09-24 | 2005-07-05 | National Research Council Of Canada | Method and apparatus for performing intra-operative angiography |
US20050182434A1 (en) * | 2000-08-11 | 2005-08-18 | National Research Council Of Canada | Method and apparatus for performing intra-operative angiography |
CN101406392B (zh) * | 1999-09-24 | 2011-05-18 | 加拿大国家研究委员会 | 用于手术中血管造影的装置 |
DE10120980B4 (de) * | 2001-05-01 | 2009-12-03 | Pulsion Medical Systems Ag | Verfahren, Vorrichtung und Computerprogramm zur Bestimmung des Blutflusses in einer Gewebe- oder Organregion |
US6757554B2 (en) * | 2001-05-22 | 2004-06-29 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution |
JP4515721B2 (ja) * | 2002-06-21 | 2010-08-04 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 灌流画像を分析するための方法、装置及びソフトウェア |
DE10257743B4 (de) * | 2002-12-10 | 2006-11-23 | Irmgard Zerrle | Vorrichtung zur Bestimmung der Perfusion in einem Gewebebereich und des Blutflusses durch einzelne Blutgefäße |
US7512436B2 (en) * | 2004-02-12 | 2009-03-31 | The Regents Of The University Of Michigan | Method of evaluating metabolism of the eye |
JP4533673B2 (ja) * | 2004-06-07 | 2010-09-01 | オリンパス株式会社 | 赤外観察システム及び赤外観察システムによる作動方法 |
WO2006014334A2 (en) * | 2004-07-06 | 2006-02-09 | Advanced Biophotonics, Inc. | Systems and methods for localizing vascular architecture, and evaluation and monitoring of functional behavior of same |
RU2288633C1 (ru) * | 2005-04-29 | 2006-12-10 | ГОУ ВПО "Красноярская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" | Способ определения границ резекции при закрытой травме поджелудочной железы с разрывом главного панкреатического протока |
US8460191B2 (en) * | 2005-05-20 | 2013-06-11 | Hitachi Medical Corporation | Ultrasonic medical diagnostic device for imaging changes with time |
JP2007021006A (ja) * | 2005-07-20 | 2007-02-01 | Hitachi Medical Corp | X線ct装置 |
DE102005044531A1 (de) * | 2005-09-16 | 2007-03-22 | Myrenne Gmbh | Verfahren zur Bestimmung einer Perfusionsverteilung |
JP4936812B2 (ja) * | 2006-07-21 | 2012-05-23 | 株式会社日本色材工業研究所 | 化粧料の成型装置および成型方法 |
KR100867977B1 (ko) * | 2006-10-11 | 2008-11-10 | 한국과학기술원 | 인도시아닌 그린 혈중 농도 역학을 이용한 조직 관류 분석장치 및 그를 이용한 조직 관류 분석방법 |
-
2009
- 2009-04-14 WO PCT/IB2009/005700 patent/WO2009127972A2/en active Application Filing
- 2009-04-14 EP EP09732993.2A patent/EP2268201B1/en active Active
- 2009-04-14 EP EP17171383.7A patent/EP3278723A1/en active Pending
- 2009-04-14 MX MX2010011249A patent/MX2010011249A/es active IP Right Grant
- 2009-04-14 JP JP2011504574A patent/JP5918532B2/ja active Active
- 2009-04-14 KR KR1020107024977A patent/KR101621107B1/ko active IP Right Grant
- 2009-04-14 CN CN200980123414.0A patent/CN102083362B/zh active Active
- 2009-04-14 KR KR1020167007994A patent/KR101759850B1/ko active IP Right Grant
- 2009-04-14 RU RU2011111078/14A patent/RU2506896C2/ru not_active IP Right Cessation
- 2009-04-14 BR BRPI0907272-1A patent/BRPI0907272A2/pt active Search and Examination
-
2011
- 2011-12-01 HK HK11113048.2A patent/HK1158482A1/xx not_active IP Right Cessation
-
2016
- 2016-01-28 JP JP2016014503A patent/JP6577877B2/ja active Active
-
2019
- 2019-05-28 JP JP2019099701A patent/JP2019193798A/ja active Pending
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10265419B2 (en) | 2005-09-02 | 2019-04-23 | Novadaq Technologies ULC | Intraoperative determination of nerve location |
US10434190B2 (en) | 2006-09-07 | 2019-10-08 | Novadaq Technologies ULC | Pre-and-intra-operative localization of penile sentinel nodes |
US10835138B2 (en) | 2008-01-25 | 2020-11-17 | Stryker European Operations Limited | Method for evaluating blush in myocardial tissue |
US9936887B2 (en) | 2008-01-25 | 2018-04-10 | Novadaq Technologies ULC | Method for evaluating blush in myocardial tissue |
US11564583B2 (en) | 2008-01-25 | 2023-01-31 | Stryker European Operations Limited | Method for evaluating blush in myocardial tissue |
US10219742B2 (en) | 2008-04-14 | 2019-03-05 | Novadaq Technologies ULC | Locating and analyzing perforator flaps for plastic and reconstructive surgery |
US10041042B2 (en) | 2008-05-02 | 2018-08-07 | Novadaq Technologies ULC | Methods for production and use of substance-loaded erythrocytes (S-IEs) for observation and treatment of microvascular hemodynamics |
US10492671B2 (en) | 2009-05-08 | 2019-12-03 | Novadaq Technologies ULC | Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest |
US11284801B2 (en) | 2012-06-21 | 2022-03-29 | Stryker European Operations Limited | Quantification and analysis of angiography and perfusion |
US10278585B2 (en) | 2012-06-21 | 2019-05-07 | Novadaq Technologies ULC | Quantification and analysis of angiography and perfusion |
US9816930B2 (en) | 2014-09-29 | 2017-11-14 | Novadaq Technologies Inc. | Imaging a target fluorophore in a biological material in the presence of autofluorescence |
US10488340B2 (en) | 2014-09-29 | 2019-11-26 | Novadaq Technologies ULC | Imaging a target fluorophore in a biological material in the presence of autofluorescence |
US10631746B2 (en) | 2014-10-09 | 2020-04-28 | Novadaq Technologies ULC | Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography |
US10992848B2 (en) | 2017-02-10 | 2021-04-27 | Novadaq Technologies ULC | Open-field handheld fluorescence imaging systems and methods |
US11140305B2 (en) | 2017-02-10 | 2021-10-05 | Stryker European Operations Limited | Open-field handheld fluorescence imaging systems and methods |
US12028600B2 (en) | 2017-02-10 | 2024-07-02 | Stryker Corporation | Open-field handheld fluorescence imaging systems and methods |
Also Published As
Publication number | Publication date |
---|---|
KR20100136540A (ko) | 2010-12-28 |
EP3278723A1 (en) | 2018-02-07 |
HK1158482A1 (en) | 2012-07-20 |
CN102083362A (zh) | 2011-06-01 |
RU2011111078A (ru) | 2012-09-27 |
EP2268201B1 (en) | 2017-05-17 |
JP2016135253A (ja) | 2016-07-28 |
BRPI0907272A2 (pt) | 2015-07-21 |
RU2506896C2 (ru) | 2014-02-20 |
MX2010011249A (es) | 2011-03-02 |
KR101621107B1 (ko) | 2016-05-13 |
WO2009127972A3 (en) | 2010-01-28 |
EP2268201A2 (en) | 2011-01-05 |
JP6577877B2 (ja) | 2019-09-18 |
JP2011519589A (ja) | 2011-07-14 |
KR101759850B1 (ko) | 2017-07-19 |
EP2268201A4 (en) | 2014-05-28 |
KR20160040315A (ko) | 2016-04-12 |
CN102083362B (zh) | 2015-04-22 |
WO2009127972A2 (en) | 2009-10-22 |
JP2019193798A (ja) | 2019-11-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6577877B2 (ja) | 組織灌流を評価するための方法及びシステム | |
JP6535717B2 (ja) | 形成外科手術のための穿通枝皮弁の位置確認及び分析 | |
CN108882896B (zh) | 用于评定组织的治愈的方法和*** | |
US8948851B2 (en) | Method and apparatus for depth-resolved fluorescence, chromophore, and oximetry imaging for lesion identification during surgery | |
KR100737620B1 (ko) | 외과 수술 중의 혈관조영술을 수행하는 방법 및 장치 | |
JP6813245B2 (ja) | 単一の画像上で解剖学的データと生理学的データとを結合するためのシステムの作動方法、コンピュータシステム、及び単一の画像上で解剖学的データと生理学的データとを結合するためのプログラムが記録された記録媒体 | |
US20140316262A1 (en) | Preoperative identification of perforator vessels in flaps to be used in reconstructive surgery | |
CN108601510A (zh) | 内窥镜观察方法和内窥镜装置 | |
JP6485275B2 (ja) | イメージング装置 | |
US20190239749A1 (en) | Imaging apparatus | |
JP6512320B2 (ja) | イメージング装置 | |
US20220211258A1 (en) | Contrast enhancement for medical imaging | |
WO2024067948A1 (en) | Method and apparatus | |
Vaassen | Intraoperative Quantification of Intestinal Microcirculation: A Modern Interpretation of Fluorescence Angiography | |
WO2018216658A1 (ja) | 撮像装置、撮像システム、及び撮像方法 | |
Stepp et al. | Endoscopic ICG perfusion imaging for flap transplants: technical development |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20120413 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20130718 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130730 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20131029 |
|
RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20131030 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20131105 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20131106 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140130 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20140818 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141218 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20150210 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150317 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20150317 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20150417 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20151214 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20160114 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160128 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160408 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5918532 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
S533 | Written request for registration of change of name |
Free format text: JAPANESE INTERMEDIATE CODE: R313533 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
R360 | Written notification for declining of transfer of rights |
Free format text: JAPANESE INTERMEDIATE CODE: R360 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |