CN105769956B - A kind of water in which rice has been washed honey Radix Notoginseng powder processed and its preparation and preparation method - Google Patents
A kind of water in which rice has been washed honey Radix Notoginseng powder processed and its preparation and preparation method Download PDFInfo
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Abstract
The present invention relates to a kind of water in which rice has been washed honey Radix Notoginseng powder processed and its preparation and preparation method.Water in which rice has been washed honey Radix Notoginseng powder processed is made up by ratio of weight and the number of copies of following medicine：5~100 parts of pseudo-ginseng, 5~60 parts of honey, 5~100 parts of water in which rice has been washed.Water in which rice has been washed of the invention honey Radix Notoginseng powder processed can improve takes the aspect side effect such as the thirsty of generation, constipation, weakness of limbs, heating after pseudo-ginseng, and with promoting the production of body fluid to quench thirst, bowl spares and stomach, invigorating the spleen, ease constipation, effect of removing toxic substances, pseudo-ginseng is not consumed while dissipate stasis of blood hemostasis and hinder body fluid, honey can also improve the mouthfeel of pseudo-ginseng simultaneously, make people be easier to take.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of water in which rice has been washed honey Radix Notoginseng powder processed and its preparation and preparation side
Method.
Background technology
Pseudo-ginseng also known as pseudo-ginseng, the dry root of panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen
And rhizome, main product is in Yunnan Wenshan Prefecture, therefore named mountain of papers pseudo-ginseng.Chinese medicine pseudo-ginseng is using its root as medicinal effects, with scattered
The effect of stasis of blood hemostasis, detumescence ding-tong.Sweet, slight bitter, temperature.Effect, dissipate stasis of blood hemostasis, detumescence ding-tong.Cure mainly for spitting blood, spit blood,
Bleeding from five sense organs or subcutaneous tissue, has blood in stool, uterine bleeding, traumatism and bleeding, chest and abdomen shouting pain, tumbling and swelling.
A large amount of medical researches prove, pseudo-ginseng can be used to treating traumatism and bleeding, hemostasis, gastrorrhagia, hematuria etc. it is various it is inside and outside go out
Mass formed by blood stasis；Expansion of blood vessels, thrombus improve microcirculation, prevention and treatment high fat of blood, cholesterol increase, coronary heart diseases and angina pectoris,
The cardiovascular and cerebrovascular diseases such as apoplexy sequela；The hepatopathys such as fatty liver, liver fibrosis and lose blood, postpartum, the reason such as prolonged illness cause
Physically weak card.Pseudo-ginseng is suppressing anticancer, anti-oxidant whitening to cardiovascular system, to body material's metabolism, to nervous system, auxiliary
The colour of skin, anti-aging and help many-sided pharmacological action such as strong, make it extensively should preventing and treating various diseases, health care aspect
With.
But because pseudo-ginseng is warm in nature, easily consumption hinders body fluid, causes the disease of the deficiency of Yin.Show as taking after pseudo-ginseng occur it is thirsty, just
Secret, weakness of limbs, heating, evening take the side effects such as insomnia.
The content of the invention
In order to solve problem of the prior art, the present invention provides a kind of rice milling swill honey Radix Notoginseng powder processed and its preparation, its
Can improve and take the aspect side effects such as the thirsty, constipation, weakness of limbs, the heating that produce after pseudo-ginseng, and with promoting the production of body fluid to quench thirst,
Bowl spares and stomach, invigorating the spleen, ease constipation, effect of removing toxic substances, make pseudo-ginseng not consumed while dissipate stasis of blood hemostasis and hinder body fluid, while honey can also change
The mouthfeel of kind pseudo-ginseng, makes people be easier to take.The present invention is achieved by the following technical solutions：
On the one hand, the invention provides a kind of water in which rice has been washed honey Radix Notoginseng powder processed, it is made by ratio of weight and the number of copies by following component
Into：5~100 parts of pseudo-ginseng, 5~60 parts of honey, 5~100 parts of water in which rice has been washed；It is preferred that 20~100 parts of pseudo-ginseng, honey 5~40 part, meter
5~80 parts of swill；More preferably 30~70 parts of pseudo-ginseng, 5~20 parts of honey, 40~80 parts of water in which rice has been washed；Most preferably 40~70 parts of pseudo-ginseng,
10~20 parts of honey, 50~70 parts of water in which rice has been washed.
Described water in which rice has been washed honey Radix Notoginseng powder processed is prepared by the method for comprising the following steps：
1）It is meal that pseudo-ginseng cleaning is smashed；
2）Choose honey add pot in heating, refine to product obtained by 105~110 DEG C, refined honey water content more than 30%,
Color and luster is without significant change, and slightly sticking refined honey is standby；
3）The water in which rice has been washed that the clear water elutriation of selection rice obtains white opacity is standby；
4）By step 2）With 3）It is well mixed that to obtain refined honey water in which rice has been washed standby；
5）Pseudo-ginseng meal after smashing is put into step 4）Temperature control is in 5~25 DEG C of soaks in the refined honey water in which rice has been washed of preparation
2~48 hours, period stirred 1 time every 6 hours, it is evenly distributed, and is impregnated with pseudo-ginseng particle and fully absorbs refined honey water in which rice has been washed；
6）By the notoginseng drying after soak to water content below 15%；
7）By step 6）Dry pseudo-ginseng is crushed as impalpable powder is obtained final product.
On the other hand, the invention provides a kind of Chinese medicine preparation, it includes above-mentioned water in which rice has been washed honey Radix Notoginseng powder processed.
Present invention also offers the preparation method of water in which rice has been washed honey Radix Notoginseng powder processed, it comprises the following steps：
1）It is meal that pseudo-ginseng cleaning is smashed；
2）Choose honey add pot in heating, refine to product obtained by 105~110 DEG C, refined honey water content more than 30%,
Color and luster is without significant change, and slightly sticking refined honey is standby；
3）The water in which rice has been washed that the clear water elutriation of selection rice obtains white opacity is standby；
4）By step 2）With 3）It is well mixed that to obtain refined honey water in which rice has been washed standby；
5）Pseudo-ginseng meal after smashing is put into step 4）Temperature control is in 5~25 DEG C of soaks in the refined honey water in which rice has been washed of preparation
2~48 hours, period stirred 1 time every 6 hours, it is evenly distributed, and is impregnated with pseudo-ginseng particle and fully absorbs refined honey water in which rice has been washed；
6）By the notoginseng drying after soak to water content below 15%；
7）By step 6）Dry pseudo-ginseng is crushed as impalpable powder is obtained final product.
Pharmacological effect side's solution of the invention is as follows：
Honey：Performance：It is sweet, put down；Returns spleen stomach, lung and large intestine channel.Function bowl spares, cough-relieving is moisturized, removing toxic substances.It is bowl spares benefit
The processing aids of gas medicine, to synergy, moisturize and correct mouthfeel.Money is processed as honey-moxibustion ginseng, honey are processed the tuber of stemona, honey and processs aster, honey
Coltsfoot, honey are processed mulberry leaf, sweet honey-fried CORTEX MORI, honey and process the fruit of Chinese magnoliavine, Radix Glycyrrhizae (processed with honey) etc..
Pseudo-ginseng：Nature and flavor are sweet, slight bitter, temperature, return through Return liver, stomach.With dissipate stasis of blood hemostasis, the effect of detumescence ding-tong.Cure mainly and cough up
Blood, is spitted blood, and bleeding from five sense organs or subcutaneous tissue is had blood in stool, and uterine bleeding, traumatism and bleeding, chest and abdomen shouting pain is fallen servant and swollen and ache.Just it is acknowledged as with significant since ancient times
Promoting blood circulation and removing blood stasis, detumescence ding-tong effect, the good reputation with " invaluable ", " southern part of the country god grass ".Spitting of blood is cured mainly, is spitted blood, bleeding from five sense organs or subcutaneous tissue, just
Blood, uterine bleeding, traumatism and bleeding, chest and abdomen shouting pain, tumbling and swelling.
Water in which rice has been washed：Nature and flavor are sweet, cool, nontoxic.Can be used for process medicine, can go it is dry and in and laxation act on, function of spleen and stomach regulating, clearly
Heat stops the effects such as polydipsia, diuresis, cool blood, removing toxic substances.
The positive effect of the present invention is：The present invention is, according to theory of traditional Chinese medical science basis, using above-mentioned compatibility, to make pseudo-ginseng and honeybee
Sweet water in which rice has been washed mutual restraint between two drugs proves effective, using honey water in which rice has been washed cool property reduction pseudo-ginseng the dry property of warm, improve thirsty, constipation, four limbs without
The side effects such as power, insomnia.Make pseudo-ginseng that the dry not heat dryness-heat that promotes the production of body fluid is removed while dissipate stasis of blood hemostasis, while improving pseudo-ginseng bitter taste mouthful again
Sense makes people be easier to take.
Specific embodiment
Embodiments below and case application, are only intended to clearly illustrate example of the present invention, and not to this
The restriction of invention.For those of ordinary skill in the art, other can also be made not on the basis of the above description
With the change or variation of form.And the obvious change thus amplified out or change still in protection scope of the present invention
Among.
Embodiment 1：
The preparation method of water in which rice has been washed honey Radix Notoginseng powder processed is as follows：
1st, 50g pseudo-ginsengs are taken, the removal of impurity, it is meal to smash, and through the drying 1 hour of 30 DEG C of low temperature, is dried to water content
20%；
2nd, take 10g honey the refining 4 minutes of 110 DEG C of temperature refined honey water is standby；
3rd, choosing 30g rice adds 300g clear water to wash by rubbing with the hands repeatedly, filters and obtains water in which rice has been washed；
4th, by step 2 and 3, well mixed to obtain refined honey water in which rice has been washed standby；
5th, the dry pseudo-ginseng raw material of step 1 is placed in refined honey water in which rice has been washed and is stirred in 25 DEG C of constant temperature soak 8 hours, phase
Between every 4 hours stir 1 time, it is evenly distributed, be impregnated with pseudo-ginseng and fully absorb refined honey water in which rice has been washed；
6th, the pseudo-ginseng that step 5 treatment is obtained is placed in low-temperature vacuum drying case, through the drying 3 hours of 30 DEG C of low temperature, is dried
To water content 15%；
7th, smash as impalpable powder is obtained final product.
Embodiment 2：
The preparation method of water in which rice has been washed honey Radix Notoginseng powder processed is as follows：
1st, 300g pseudo-ginsengs are taken, the removal of impurity, it is meal to smash, and through the drying 1 hour of 30 DEG C of low temperature, is dried to water content
20%；
2nd, take 200g honey the refining 10 minutes of 110 DEG C of temperature refined honey water is standby；
3rd, choosing 150g rice adds 1000g clear water to wash by rubbing with the hands repeatedly, filters and obtains water in which rice has been washed；
4th, by step 2 and 3, well mixed to obtain refined honey water in which rice has been washed standby；
5th, the dry pseudo-ginseng raw material of step 1 is placed in refined honey water in which rice has been washed and is stirred in 22 DEG C of constant temperature soak 12 hours,
Period stirred 1 time every 4 hours, it is evenly distributed, and is impregnated with pseudo-ginseng and fully absorbs refined honey water in which rice has been washed；
6th, the pseudo-ginseng that step 5 treatment is obtained is placed in low-temperature vacuum drying case, through the drying 5 hours of 23 DEG C of low temperature, is dried
To water content 13%；
7th, smash as impalpable powder is obtained final product.
Embodiment 3：
The preparation method of water in which rice has been washed honey Radix Notoginseng powder processed is as follows：
1st, 100g pseudo-ginsengs are taken, the removal of impurity, it is meal to smash, and through the drying 1 hour of 28 DEG C of low temperature, is dried to water content
20%；
2nd, take 80g honey the refining 7 minutes of 110 DEG C of temperature refined honey water is standby；
3rd, choosing 60g rice adds 700g clear water to wash by rubbing with the hands repeatedly, filters and obtains water in which rice has been washed；
4th, by step 2 and 3, well mixed to obtain refined honey water in which rice has been washed standby；
5th, the dry pseudo-ginseng raw material of step 1 is placed in refined honey water in which rice has been washed and is stirred in 18 DEG C of constant temperature soak 8 hours, phase
Between every 4 hours stir 1 time, it is evenly distributed, be impregnated with pseudo-ginseng and fully absorb refined honey water in which rice has been washed；
6th, the pseudo-ginseng that step 5 treatment is obtained is placed in low-temperature vacuum drying case, through the drying 2 hours of 25 DEG C of low temperature, is dried
To water content 14%；
7th, smash as impalpable powder is obtained final product.
Test example 1：Pharmacodynamic Data
For the validity for proving the invention has carried out pharmacological evaluation in terms of pharmacodynamics, it is reported as follows：
1st, test material
1-1 medicines：Primary Radix Notoginseng powder and water in which rice has been washed honey Radix Notoginseng powder processed, by Jilin Province north domain, American Ginseng research Co., Ltd carries
For lot number 20151115.Dosage setting by people and animal body surface area equivalent dosage conversions, people's daily maximum dose level（9g/
60kg）Equivalent to mouse 1.2g/kg.Therefore this experiment setting primary Radix Notoginseng powder of mouse and water in which rice has been washed honey Radix Notoginseng powder dosage processed are
0.6th, 1.2,2.4g/kg groups, required concentration is configured to during experiment with 0.5% sodium carboxymethylcellulose.
1-2 animals：ICR mouse, 18~22g of body weight, quality certification number：SCXK（It is lucky）2015-0003, is asked in vain by Jilin University
The animal experimental center supply of grace medical college.Raise ground：Bethune medical college of Jilin University animal experimental center.
2nd, test method
ICR mouse 140,18~22g, male and female half and half.7 groups are randomly divided into by sex, body weight, i.e.,：Control group, primary three
The basic, normal, high dosage group of seven powder and the water in which rice has been washed honey basic, normal, high dosage group of Radix Notoginseng powder processed, every group of each 10 of male and female.Gavage capacity is equal
It is 20ml/kg, one time a day, continuous 30 days.In administration 30 days, the equal intraperitoneal injection yellow Jackets 50mg/kg of each group mouse, note
Incubation period and the length of one's sleep that record is slept in 30 minutes.
3rd, observation index
Each group observes lower index for 10,20,30 days respectively in administration：
（1）Autonomic activities situation in mouse 10 minutes；
（2）Mouse symptom and sign：The expression of animal, activity（Grab nose, itch etc.）Situation；
（3）The mouse amount of drinking water of 24 hours, urine volume and color, excrement shape etc. change.
4th, result of the test
Mouse autonomic activities is observed respectively within 10,20,30 days, compare with control group, the primary middle and high dosage of Radix Notoginseng powder in administration
Group can substantially increase mouse autonomic activities number of times（p<0.05）, the water in which rice has been washed honey basic, normal, high dosage group of Radix Notoginseng powder processed has no obvious
Difference（p>0.05）, it is shown in Table 1.
Mouse amount of drinking water and urine volume situation of change are observed respectively within 10,20,30 days, compare with control group, primary three in administration
The middle and high dosage group of seven powder can substantially increase mouse amount of drinking water and urine volume in 20,30 days in administration（p<0.05）, water in which rice has been washed honey system three
The basic, normal, high dosage group of seven powder has no notable difference（p>0.05）, it is shown in Table 2.
In administration observation mouse urine volume color, excrement shape, the expression of animal, activity respectively in 10,20,30 days（Grab nose, scabies
Itch）Situation, compares with control group, and the primary visible mouse expression of the middle and high dosage group of Radix Notoginseng powder is irritated, and activity increases, and urine volume increases
It is many, darken, excrement is excluded and reduced, and shape is hard, and the water in which rice has been washed honey basic, normal, high dosage group of Radix Notoginseng powder processed has no notable difference；
It is shown in Table 3.
In administration 30 days, observation was compared, primary pseudo-ginseng the synergy of threshold dose yellow Jackets sleep with control group
The middle and high dosage group of powder can be obviously prolonged Sleep latency, and curtail sleep（p<0.05）, water in which rice has been washed honey Radix Notoginseng powder processed
Basic, normal, high dosage group has no notable difference（p>0.05 or p<0.01）, it is shown in Table 4.
The influence of the primary Radix Notoginseng powder of table 1 and the present invention to mouse autonomic activities（± S, n=10）
Compare with control group, * p<0.05
The primary Radix Notoginseng powder of table 2 and the present invention are on mouse water uptake influence in 24 hours（± S, n=10）
Compare with control group, * p<0.05
The primary Radix Notoginseng powder of table 3 and the present invention influence on mouse twenty-four-hour urine amount（± S, n=10）
Compare with control group, * p<0.05
The influence of the primary Radix Notoginseng powder of table 4 and the present invention to mouse yellow Jackets hypnosis（± S, n=10）
Compare with control group, * p<0.05, * * p<0.01
5th, conclusion (of pressure testing)
Primary Radix Notoginseng powder can substantially increase mouse autonomic activities number of times, hence it is evident that increase mouse amount of drinking water and urine volume, can make small
Mouse expression is irritated, and activity increases, and hydrouria darkens, and excrement is excluded and reduced, and shape is hard, to threshold dose amobarbital
Sodium sleep has synergy, can be obviously prolonged Sleep latency, and curtails sleep, and points out primary Radix Notoginseng powder continuous oral
1 month, animal can be made the side effects such as thirsty, constipation, insomnia occur.Continuous oral of the present invention 1 month, has no that obvious animal occurs
The side effects such as thirsty, dysphoria with smothery sensation, constipation, insomnia.
Test example 2：Typical case
1st, certain female, 32 years old, tcm diagnosis：Blood stasis trembled with fear, insufficiency of vital energy and blood causes irregular menstruation, and hypomenorrhia is small with stasis of blood block
Abdomen pain, poor appetite.
Treatment：Take primary Radix Notoginseng powder after 1 week symptom be obviously improved, but there is dysphoria with smothery sensation, thirsty, constipation symptom.After use
Radix Notoginseng powder prepared by the embodiment of the present invention 1, often takes 3 grams, and 3 times a day.
Effect：Dysphoria with smothery sensation, thirsty, constipation symptom are improved after using water in which rice has been washed honey of the present invention Radix Notoginseng powder processed instead, is continuously taken
Do not occur any side effect after 15 days yet, and disease is fully recovered.
2nd, certain man, 45 years old, diagnosis：Stomachache bleeding, chronic gastritis, gastric ulcer etc. are with melena.
Treatment：Ground with Radix Notoginseng powder and taken, compatibility cattail pollen, excrementum pteropi, the red sage root, corydalis tuber.3 doses are taken, rear symptom is obtained
Improve, while occurring in that the side effect that pseudo-ginseng causes again：Thirsty, constipation, slight insomnia.
Effect：Primary Radix Notoginseng powder is then used the water in which rice has been washeds honey Radix Notoginseng powders processed of 2 preparations in the embodiment of the present invention instead, after 2 doses
Thirsty, constipation, mild insomnia shape disappear.Patient's appetite simultaneously takes a turn for the better, and has a stomach upset and is very significantly improved, and continuously takes 2
Gastroscope check after month, recovery from illness.
3rd, certain man, diagnoses for 50 years old：Hemorrhagic strokes sequelae, left limb is numb, facial paralysis, moderate activity obstacle.
Treatment：Radix Notoginseng powder individually is taken, 3 times a day, each 3g, after continuously taking 2 weeks, because dyskinesia occurs seriously
Constipation, while with thirsty, the side reaction such as dysphoria with smothery sensation, weakness of limbs.
Effect：By primary Radix Notoginseng powder, this uses the water in which rice has been washed honey Radix Notoginseng powder processed in the embodiment of the present invention 3, constipation, dysphoria with smothery sensation, mouth afterwards
Thirsty side reaction disappears, and does not occur any side effect after continuously taking 45 days yet, and extremity numbness symptom is very significantly improved, fortune
Dynamic obstacle is changed into slight from moderate, and the quality of life to patient improves a lot.
Claims (1)
1. the preparation method of a kind of water in which rice has been washed honey Radix Notoginseng powder processed, it is characterised in that the sweet Radix Notoginseng powder processed of described water in which rice has been washed by it is following into
Divide and be made by ratio of weight and the number of copies：40~70 parts of pseudo-ginseng, 10~20 parts of honey, 50~70 parts of water in which rice has been washed；Methods described includes as follows
Step：
1）It is meal that pseudo-ginseng cleaning is smashed；
2）Choose honey add pot in heating, refine to product obtained by 105~110 DEG C, refined honey water content more than 30%, color and luster
Without significant change, slightly sticking refined honey is standby；
3）The water in which rice has been washed that the clear water elutriation of selection rice obtains white opacity is standby；
4）By step 2）With 3）It is well mixed that to obtain refined honey water in which rice has been washed standby；
5）Pseudo-ginseng meal after smashing is put into step 4）In the refined honey water in which rice has been washed of preparation temperature control 5~25 DEG C of soaks 2~
48 hours, period stirred 1 time every 6 hours, it is evenly distributed, and is impregnated with pseudo-ginseng particle and fully absorbs refined honey water in which rice has been washed；
6）By the notoginseng drying after soak to water content below 15%；
7）By step 6）Dry pseudo-ginseng is crushed as impalpable powder is obtained final product.
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