CN105769956A - Radix notoginseng powder processed with honey and rice water and preparation and preparation method of radix notoginseng powder - Google Patents
Radix notoginseng powder processed with honey and rice water and preparation and preparation method of radix notoginseng powder Download PDFInfo
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Abstract
The invention relates to radix notoginseng powder processed with honey and rice water and a preparation and a preparation method of the radix notoginseng powder.The radix notoginseng powder processed with honey and rice water is prepared from, by weight, 5-100 parts of radix notoginseng, 5-60 parts of honey and 5-100 parts of rice water.By means of the radix notoginseng powder processed with honey and rice water, side effects generated by taking radix notoginseng such as thirst, constipation, weakness of limbs, fever and the like can be improved, the effects of promoting the production of body fluid to relieve thirst, strengthening the middle warmer and harmonizing the stomach, tonifying the spleen, moistening the intestines and removing toxin so that radix notoginseng can disperse blood stasis and stop bleeding without consuming body fluid, and meanwhile the honey can improve taste of radix notoginseng so that people can take the radix notoginseng powder more easily.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of rice-washed water processed with honey Radix Notoginseng powder and preparation thereof and preparation method.
Background technology
Radix Notoginseng has another name called Radix Notoginseng, the dry root of panax araliaceae plant Panaxnotoginseng (Burk.) F.H.Chen and rhizome, and main product is in Yunnan Wenshan Prefecture, therefore named mountain of papers Radix Notoginseng.Chinese crude drug Radix Notoginseng is using its root as medicinal effects, has dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain.Sweet in the mouth, micro-hardship, temperature.Effect, dissipating blood stasis stops blooding, subduing swelling and relieving pain.Cure mainly for spitting blood, spit blood, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.
A large amount of medical researches prove, Radix Notoginseng can be used for treating the various inside and outside hemorrhages such as traumatic hemorrhage, blood stasis, gastrorrhagia, hematuria；Expansion blood vessel, thrombus, improves microcirculation, the cardiovascular and cerebrovascular disease such as prevention and treatment hyperlipidemia, cholesterol increase, coronary heart diseases and angina pectoris, apoplexy sequela；The hepatopathy such as fatty liver, hepatic fibrosis and lose blood, body deficiency syndrome that puerperal, the reason such as prolonged illness cause.Radix Notoginseng, to cardiovascular system, to body material's metabolism, nervous system, auxiliary are suppressed anticancer, the antioxidation whitening colour of skin, slow down aging and tonification many-sided pharmacological action such as strong, makes it prevent and treat multiple disease, health care aspect extensive use.
But owing to Radix Notoginseng is warm in nature, easily consumption impairment of body fluid liquid, causes the disease of the deficiency of YIN.Show as and after taking Radix Notoginseng, occur that thirsty, constipation, myasthenia of limbs, heating, evening take the side effect such as insomnia.
Summary of the invention
In order to solve a difficult problem of the prior art, the present invention provides a kind of rice milling water from washing rice processed with honey Radix Notoginseng powder and preparation thereof, its can improve take produce after Radix Notoginseng thirsty, constipation, myasthenia of limbs, the aspect side effect such as heating, and there is promoting the production of body fluid to quench thirst, invigorating middle warmer stomach function regulating, spleen invigorating, intestine moistening, removing toxic substances effect, make Radix Notoginseng dissipating blood stasis stop blooding while do not consume impairment of body fluid liquid, Mel also can improve the mouthfeel of Radix Notoginseng simultaneously, makes people be easier to take.The present invention is achieved by the following technical solutions:
On the one hand, the invention provides a kind of rice-washed water processed with honey Radix Notoginseng powder, it is made up by ratio of weight and the number of copies of following component: Radix Notoginseng 5～100 parts, Mel 5～60 parts, rice-washed water 5～100 parts；Preferred Radix Notoginseng 20～100 parts, Mel 5～40 parts, rice-washed water 5～80 parts；More preferably Radix Notoginseng 30～70 parts, Mel 5～20 parts, rice-washed water 40～80 parts；Most preferably Radix Notoginseng 40～70 parts, Mel 10～20 parts, rice-washed water 50～70 parts.
Described rice-washed water processed with honey Radix Notoginseng powder is prepared by the method comprised the steps:
1) Radix Notoginseng is cleaned smashing for coarse powder；
2) choosing Mel and add heating in pot, the goods that refining obtains to 105～110 DEG C, refined honey water content is more than 30%, and color and luster is without significant change, and slightly sticking refined honey is standby；
3) choose rice clear water and eluriate that to obtain the rice-washed water of white opacity standby；
4) by step 2) and 3) to obtain refined honey rice-washed water standby for mix homogeneously；
5) the Radix Notoginseng coarse powder after smashing being put into temperature in refined honey rice-washed water prepared by step 4) and control 5～25 DEG C of leaching systems 2～48 hours, period stirred 1 time every 6 hours so that it is is evenly distributed, soaks into Radix Notoginseng granule and fully absorb refined honey rice-washed water；
6) by the notoginseng drying after leaching system to water content less than 15%；
7) Radix Notoginseng step 6) dried is pulverized as impalpable powder and get final product.
On the other hand, the invention provides a kind of Chinese medicine preparation, it comprises above-mentioned rice-washed water processed with honey Radix Notoginseng powder.
The preparation method that present invention also offers rice-washed water processed with honey Radix Notoginseng powder, it comprises the steps:
1) Radix Notoginseng is cleaned smashing for coarse powder；
2) choosing Mel and add heating in pot, the goods that refining obtains to 105～110 DEG C, refined honey water content is more than 30%, and color and luster is without significant change, and slightly sticking refined honey is standby；
3) choose rice clear water and eluriate that to obtain the rice-washed water of white opacity standby；
4) by step 2) and 3) to obtain refined honey rice-washed water standby for mix homogeneously；
5) the Radix Notoginseng coarse powder after smashing being put into temperature in refined honey rice-washed water prepared by step 4) and control 5～25 DEG C of leaching systems 2～48 hours, period stirred 1 time every 6 hours so that it is is evenly distributed, soaks into Radix Notoginseng granule and fully absorb refined honey rice-washed water；
6) by the notoginseng drying after leaching system to water content less than 15%；
7) Radix Notoginseng step 6) dried is pulverized as impalpable powder and get final product.
The pharmacological effect side of the present invention solves as follows:
Mel: performance: sweet in the mouth is flat；Return taste, lung and large intestine channel.Function invigorating middle warmer, cough-relieving, moisturize, removing toxic substances.For the processing aids of invigorating the spleen and replenishing QI medicine, in order to potentiation, moisturize and correct mouthfeel.Such as Radix Ginseng (processed with honey), the processed with honey Radix Stemonae, Radix Asteris (processed with honey), processed with honey Flos Farfarae, processed with honey Folium Mori, processed with honey Cortex Mori, processed with honey Fructus Schisandrae Chinensis, Radix Glycyrrhizae (processed with honey) etc..
Radix Notoginseng: nature and flavor hardship sweet, micro-, temperature, return through returning liver, stomach warp.There is dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain.Cure mainly spitting of blood, spit blood, epistaxis, to have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling down swells and ache.Just it is acknowledged as since ancient times and there is significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, there is the good reputation of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ", " southern part of the country SHENCAO ".Cure mainly spitting of blood, spit blood, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.
Rice-washed water: nature and flavor are sweet, cool, nontoxic.Can be used for concocting medicine, can go dry and in and laxation effect, function of spleen and stomach regulating, heat clearing away stops the effects such as excessive thirst, diuresis, removing heat from blood, removing toxic substances.
The positive effect of the present invention is in that: the present invention is based on theory of Chinese medical science basis, utilize above-mentioned compatibility, make Radix Notoginseng and Mel rice-washed water mutual restraint between two drugs prove effective, utilize the cool property of Mel rice-washed water to reduce the dry property of warm of Radix Notoginseng, improve the side effect such as thirsty, constipation, myasthenia of limbs, insomnia.Make Radix Notoginseng remove the dry hot dryness-fire that cannot not promote the production of body fluid rawly while dissipating blood stasis stops blooding, improve again Radix Notoginseng bitterness mouthfeel simultaneously and make people be easier to take.
Detailed description of the invention
Embodiments below and case application, be only for clearly demonstrating example of the present invention, and be not limitation of the invention.For those of ordinary skill in the field, other multi-form change or variations can also be made on the basis of the above description.And the apparent change thus amplified out or variation are still among protection scope of the present invention.
Embodiment 1:
The preparation method of rice-washed water processed with honey Radix Notoginseng powder is as follows:
1, take 50g pseudo-ginseng, the removal of impurity, smash as coarse powder, through dry 1 hour of low temperature 30 DEG C, be dried to water content 20%；
2, take 10g Mel temperature 110 DEG C refine 4 minutes refined honey water standby；
3, choose 30g rice addition 300g clear water repeatedly to wash by rubbing with the hands, filter and obtain rice-washed water；
4, step 2 and 3 mix homogeneously are obtained refined honey rice-washed water standby；
5, being placed in refined honey rice-washed water by the Radix Notoginseng raw material that step 1 is dry and stir soak system 8 hours constant temperature 25 DEG C, period stirred 1 time every 4 hours so that it is is evenly distributed, soaks into Radix Notoginseng and fully absorb refined honey rice-washed water；
6, step 5 is processed the Radix Notoginseng obtained and be placed in low-temperature vacuum drying case, dry 3 hours through low temperature 30 DEG C, be dried to water content 15%；
7, smash as impalpable powder and get final product.
Embodiment 2:
The preparation method of rice-washed water processed with honey Radix Notoginseng powder is as follows:
1, take 300g pseudo-ginseng, the removal of impurity, smash as coarse powder, through dry 1 hour of low temperature 30 DEG C, be dried to water content 20%；
2, take 200g Mel temperature 110 DEG C refine 10 minutes refined honey water standby；
3, choose 150g rice to add 1000g clear water and repeatedly wash by rubbing with the hands, filter and rice-washed water；
4, step 2 and 3 mix homogeneously are obtained refined honey rice-washed water standby；
5, being placed in refined honey rice-washed water by the Radix Notoginseng raw material that step 1 is dry and stir soak system 12 hours constant temperature 22 DEG C, period stirred 1 time every 4 hours so that it is is evenly distributed, soaks into Radix Notoginseng and fully absorb refined honey rice-washed water；
6, step 5 is processed the Radix Notoginseng obtained and be placed in low-temperature vacuum drying case, dry 5 hours through low temperature 23 DEG C, be dried to water content 13%；
7, smash as impalpable powder and get final product.
Embodiment 3:
The preparation method of rice-washed water processed with honey Radix Notoginseng powder is as follows:
1, take 100g pseudo-ginseng, the removal of impurity, smash as coarse powder, through dry 1 hour of low temperature 28 DEG C, be dried to water content 20%；
2, take 80g Mel temperature 110 DEG C refine 7 minutes refined honey water standby；
3, choose 60g rice to add 700g clear water and repeatedly wash by rubbing with the hands, filter and rice-washed water；
4, step 2 and 3 mix homogeneously are obtained refined honey rice-washed water standby；
5, being placed in refined honey rice-washed water by the Radix Notoginseng raw material that step 1 is dry and stir soak system 8 hours constant temperature 18 DEG C, period stirred 1 time every 4 hours so that it is is evenly distributed, soaks into Radix Notoginseng and fully absorb refined honey rice-washed water；
6, step 5 is processed the Radix Notoginseng obtained and be placed in low-temperature vacuum drying case, dry 2 hours through low temperature 25 DEG C, be dried to water content 14%；
7, smash as impalpable powder and get final product.
Test example 1: Pharmacodynamic Data
Effectiveness for proving this invention has carried out pharmacological evaluation from pharmacodynamics aspect, is reported as follows:
1, test material
1-1 medicine: primary Radix Notoginseng powder and rice-washed water processed with honey Radix Notoginseng powder, territory, north, Jilin Province Radix Panacis Quinquefolii studying company limited provides, lot number 20151115.Dosage setting is by people and animal body surface area equivalent dosage conversions, and people's daily maximum dose level (9g/60kg) is equivalent to mice 1.2g/kg.Therefore this test set the primary Radix Notoginseng powder of mice and rice-washed water processed with honey Radix Notoginseng powder dosage be 0.6,1.2,2.4g/kg group, be all configured to desired concn with 0.5% sodium carboxymethyl cellulose during test.
1-2 animal: ICR mice, body weight 18～22g, the quality certification number: SCXK(is lucky) 2015-0003, Jilin University Bethune medical college animal experimental center supply.Raise ground: Jilin University Bethune medical college animal experimental center.
2, test method
ICR mice 140,18～22g, male and female half and half.It is randomly divided into 7 groups, it may be assumed that matched group, primary Radix Notoginseng powder basic, normal, high dosage group and the basic, normal, high dosage group of rice-washed water processed with honey Radix Notoginseng powder, often each 10 of male and female of group by sex, body weight.Gavage capacity is 20ml/kg, every day 1 time, continuous 30 days.In administration 30 days, respectively organize the equal lumbar injection pentobarbital sodium 50mg/kg of mice, the incubation period slept in recording 30 minutes and the length of one's sleep.
3, observation index
Each group all observes lower index for 10,20,30 days respectively in administration:
(1) 10 minutes interior autonomic activities situations of mice；
(2) mice symptom and sign: the expression of animal, activity (grabbing nose, pruritus etc.) situation；
(3) the mice amount of drinking water of 24 hours, urine volume and color, feces shape etc. change.
4, result of the test
Within 10,20,30 days, mice autonomic activities is observed respectively in administration, compare with matched group, the middle and high dosage group of primary Radix Notoginseng powder all can substantially increase mice autonomic activities number of times (p<0.05), and the basic, normal, high dosage group of rice-washed water processed with honey Radix Notoginseng powder has no notable difference (p>0.05), in Table 1.
Within 10,20,30 days, mice amount of drinking water and urine volume situation of change is observed respectively in administration, compare with matched group, the middle and high dosage group of primary Radix Notoginseng powder all can substantially increase mice amount of drinking water and urine volume (p<0.05) for 20,30 days in administration, the basic, normal, high dosage group of rice-washed water processed with honey Radix Notoginseng powder has no notable difference (p>0.05), in Table 2.
Within 10,20,30 days, mice urine volume color, feces shape, the expression of animal, activity (grabbing nose, pruritus etc.) situation is observed respectively in administration, compare with matched group, the visible mice expression of primary Radix Notoginseng powder middle and high dosage group is irritated, movable increase, hydrouria, darkens, and feces gets rid of minimizing, shape is hard, and the basic, normal, high dosage group of rice-washed water processed with honey Radix Notoginseng powder has no notable difference；In Table 3.
In administration 30 days, observe the synergism to the sleep of threshold dose pentobarbital sodium, compare with matched group, the middle and high dosage group of primary Radix Notoginseng powder all can be obviously prolonged Sleep latency, and curtail sleep (p<0.05), the basic, normal, high dosage group of rice-washed water processed with honey Radix Notoginseng powder has no notable difference (p>0.05 or p<0.01), in Table 4.
The primary Radix Notoginseng powder of table 1 and the present invention impact (± S, n=10) on mice autonomic activities
Compare with matched group, * p < 0.05
The primary Radix Notoginseng powder of table 2 and the present invention are on 24 hours water uptakes impact (± S, n=10) of mice
Compare with matched group, * p < 0.05
Mice twenty-four-hour urine amount is affected (± S, n=10) by the primary Radix Notoginseng powder of table 3 and the present invention
Compare with matched group, * p < 0.05
The primary Radix Notoginseng powder of table 4 and the present invention impact (± S, n=10) on mice pentobarbital sodium hypnosis
Compare with matched group, * p < 0.05, * * p < 0.01
5, conclusion (of pressure testing)
Primary Radix Notoginseng powder can substantially increase mice autonomic activities number of times, hence it is evident that increases mice amount of drinking water and urine volume, and mice expression can be made irritated, movable increase, hydrouria, darkens, and feces gets rid of minimizing, shape is hard, the sleep of threshold dose pentobarbital sodium is had synergism, Sleep latency can be obviously prolonged, and curtail sleep, point out primary Radix Notoginseng powder continuous oral 1 month, can make animal that the side effect such as thirsty, constipation, insomnia occur.Continuous oral of the present invention 1 month, has no obvious animal and the side effect such as thirsty, dysphoria with smothery sensation, constipation, insomnia occurs.
Test example 2: typical case
1, certain female, 32 years old, tcm diagnosis: blood stasis body is trembled with fear, and insufficiency of vital energy and blood causes menoxenia, and hypomenorrhea, with stasis of blood block, lower abdomen pain, inappetence.
Treatment: take primary Radix Notoginseng powder after 1 week symptom be obviously improved, but dysphoria with smothery sensation, thirsty, constipation symptom occur.The Radix Notoginseng powder of the rear use embodiment of the present invention 1 preparation, often takes 3 grams, every day 3 times.
Effect: improve the symptom of dysphoria with smothery sensation, thirsty, constipation after using rice-washed water processed with honey Radix Notoginseng powder of the present invention instead, does not occur any side effect and disease recovery from illness yet after taking 15 days continuously.
2, certain man, 45 years old, diagnosis: having a stomachache hemorrhage, chronic gastritis, gastric ulcer etc. are with melena.
Treatment: grind with Radix Notoginseng powder and take, compatibility Pollen Typhae, Oletum Trogopterori, Radix Salviae Miltiorrhizae, Rhizoma Corydalis.Taking 3 doses, rear symptom improves, and simultaneously occurs in that again the side effect that Radix Notoginseng causes: thirsty, constipation, slightly have a sleepless night.
Effect: primary Radix Notoginseng powder uses instead in the embodiment of the present invention rice-washed water processed with honey Radix Notoginseng powder of 2 preparations subsequently, thirsty after 2 doses, constipation, mild insomnia shape disappear.Patient's appetite simultaneously takes a turn for the better, and stomach discomfort is very significantly improved, and after taking February continuously, gastroscope is checked, recovery from illness.
3, certain man, diagnosis in 50 years old: Hemorrhagic strokes sequela, left limb is numb, facial hemiparalysis, moderate activity obstacle.
Treatment: individually take Radix Notoginseng powder, every day 3 times, each 3g, after taking 2 weeks continuously, owing to serious constipation occurs in the dyskinesia, simultaneously with thirsty, the side reaction such as dysphoria with smothery sensation, myasthenia of limbs.
Effect: after by primary Radix Notoginseng powder this with the rice-washed water processed with honey Radix Notoginseng powder in embodiment of the present invention 3, constipation, dysphoria with smothery sensation, thirsty side reaction disappear, any side effect does not occur after taking 45 days continuously yet, and numb limbs and tense tendons symptom is very significantly improved, the dyskinesia is become slightly, the quality of life of patient being improved a lot from moderate.
Claims (4)
1. a rice-washed water processed with honey Radix Notoginseng powder, it is characterised in that be made up by ratio of weight and the number of copies of following component:
Radix Notoginseng 5～100 parts, Mel 5～60 parts, rice-washed water 5～100 parts；Preferred Radix Notoginseng 20～100 parts, Mel 5～40 parts, rice-washed water 5～80 parts；More preferably Radix Notoginseng 30～70 parts, Mel 5～20 parts, rice-washed water 40～80 parts；Most preferably Radix Notoginseng 40～70 parts, Mel 10～20 parts, rice-washed water 50～70 parts.
2. a kind of rice-washed water processed with honey Radix Notoginseng powder as claimed in claim 1, it is characterised in that prepared by the method comprised the steps:
1) Radix Notoginseng is cleaned smashing for coarse powder；
2) choosing Mel and add heating in pot, the goods that refining obtains to 105～110 DEG C, refined honey water content is more than 30%, and color and luster is without significant change, and slightly sticking refined honey is standby；
3) choose rice clear water and eluriate that to obtain the rice-washed water of white opacity standby；
4) by step 2) and 3) to obtain refined honey rice-washed water standby for mix homogeneously；
5) the Radix Notoginseng coarse powder after smashing being put into temperature in refined honey rice-washed water prepared by step 4) and control 5～25 DEG C of leaching systems 2～48 hours, period stirred 1 time every 6 hours so that it is is evenly distributed, soaks into Radix Notoginseng granule and fully absorb refined honey rice-washed water；
6) by the notoginseng drying after leaching system to water content less than 15%；
7) Radix Notoginseng step 6) dried is pulverized as impalpable powder and get final product.
3. a Chinese medicine preparation, it is characterised in that comprise rice-washed water processed with honey Radix Notoginseng powder as claimed in claim 1 or 2.
4. the preparation method of rice-washed water processed with honey Radix Notoginseng powder as claimed in claim 1, it is characterised in that comprise the steps:
1) Radix Notoginseng is cleaned smashing for coarse powder；
2) choosing Mel and add heating in pot, the goods that refining obtains to 105～110 DEG C, refined honey water content is more than 30%, and color and luster is without significant change, and slightly sticking refined honey is standby；
3) choose rice clear water and eluriate that to obtain the rice-washed water of white opacity standby；
4) by step 2) and 3) to obtain refined honey rice-washed water standby for mix homogeneously；
5) the Radix Notoginseng coarse powder after smashing being put into temperature in refined honey rice-washed water prepared by step 4) and control 5～25 DEG C of leaching systems 2～48 hours, period stirred 1 time every 6 hours so that it is is evenly distributed, soaks into Radix Notoginseng granule and fully absorb refined honey rice-washed water；
6) by the notoginseng drying after leaching system to water content less than 15%；
7) Radix Notoginseng step 6) dried is pulverized as impalpable powder and get final product.
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| CN108938695A (en) * | 2018-08-01 | 2018-12-07 | 安徽金国源中药股份有限公司 | A kind of manufacture craft of ripe Radix Notoginseng powder |
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|---|---|---|---|---|
| CN108938695A (en) * | 2018-08-01 | 2018-12-07 | 安徽金国源中药股份有限公司 | A kind of manufacture craft of ripe Radix Notoginseng powder |
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|---|---|
| CN105769956B (en) | 2017-06-09 |
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