A kind of solid beverage of improving water flood and preparation method
Technical field
The invention belongs to medical art, relate to traditional Chinese medicine technology, particularly a kind of solid beverage of improving water flood and preparation method.
Background technology
Insomnia refers to difficulty falling asleep, and in the middle of sleep, easily awake dormancy poor quality of keeping alert while in bed early, the length of one's sleep obviously reduce, and have serious patient also to lie awake all night.Chronic insomnia easily causes vexed easy random, fatigue and weak, even with headache, dreaminess, hyperhidrosis, hypomnesis, also can cause a series of clinical symptoms, and brings out some psychosomatic diseases.
The harm of insomnia is apparent, from short-term effect, does not have enough sleep and can cause lethargy, tired out unable, and emotional lability is absent minded, and directly impact is work and the study of second day.And from the point of long-term development, endangering huge and far-reaching especially: Most patients chronic insomnia, difficulty falling asleep, easily causes anxiety neurosis; Insomnia is possible of bringing out certain potential disease simultaneously, as autonomic nervous dysfunction, Yi Huan function of nervous system is hyperfunction, easily occur the hyperhidrosis of the trick heart, cardiopalmus, increased heart rate, rapid breathing, muscle contraction, tremble, urgent micturition frequent micturition, chest have constriction, abdominal distention and rush down, pharyngeal obstruction sense, hyperhidrosis, limbs fatigue, the symptom such as numbness; Insomnia also can cause great harm to the social nature of man, and due to chronic insomnia, people can become suspicious, responsive, irritability, and self-doubt, and these certainly will affect the inter personal contact of its each side in family and work, thus produce feeling of lonely, sense of defeat.
Chinese medicine is particular about the process of " supporting slowly " to the conditioning of the person, takes effect perhaps be not as fast as Western medicine, but as long as suited the medicine to the illness, just can remove old complaint, take stopgap measures and effect a permanent cure.Existing Chinese medicine with decoction or pill more, mostly be and sooner or later take for twice, the eating method of this right place often can be taken medicine to causing patient forgets because of precipitate thing, thus can have a strong impact on therapeutic effect.
Also there is the prescriptions of Chinese medicine of some Cure for insomnias in prior art, but mostly because compatibility is inaccurate or dose is not suitable for, make therapeutic effect and not obvious.
The TCM knowledge of insomnia: the traditional Chinese medical science thinks that insomnia reason is a lot, but " disarmony between the heart and kidney " causes having a sleepless night reason the most common, " disarmony between the heart and kidney " refers to a kind of state that the yin, yang of the heart and kidney, water, fiery relation are lacked of proper care, relate to the large internal organs of the heart, kidney and liver three, " dialectical record " is recorded: " heart is for meeting at kidney; and liver leads to its gas; and kidney is for meeting at the heart; and liver leads its Tianjin; natural soul is fixed and god pacifies ", visible tranquillizing and allaying excitement need coordinate the large internal organs of heart, kidney and liver three, should select the medicine into heart channel, kidney channel and soothing the liver QI invigorating.
The present invention proposes a kind of solid beverage of improving water flood, in strict accordance with the preparation of traditional Chinese medical science compatibility theory, and through a large amount of zoopery and clinical experiment checking, there is the effect of good improving water flood; In addition, it is drink form that the present invention takes mode, in daily life, no matter is in motor process, or in rest process, can takes at any time as beverage, really reach the effect of " supporting slowly ".
Summary of the invention
The present invention proposes a kind of solid beverage and preparation method of improving water flood, solves the undesirable and instructions of taking of Cure for insomnia effect in prior art and does not follow the problem that the traditional Chinese medical science " supports " principle slowly.
A kind of solid beverage of improving water flood, raw material is prepared with parts by weight, is made up of Radix Rehmanniae 12 parts, Bulbus Lilii 12 parts, Radix Asparagi 9 parts, Rhizoma Phragmitis 20 parts, 5 parts, Colla Corii Asini, Radix Et Caulis Acanthopanacis Senticosi 9 parts, Fructus Lycii 9 parts, Semen Ziziphi Spinosae 9 parts, Semen Platycladi 9 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, 9 parts, Poria, Fructus Schisandrae Chinensis 9 parts, Fructus Mori 9 parts, Concha Ostreae 5 parts, 9 parts, Radix Glycyrrhizae.
Make a preparation method for solid beverage, comprise the steps:
Step 1: prepare raw material by above-mentioned parts by weight;
Step 2: the Rhizoma Atractylodis Macrocephalae is cut into slices, the thick 2 ~ 4mm of control strip, fries to yellowish-brown with processed with honey Testa Tritici, takes out, and sieve removes processed with honey wheat bran, obtains Rhizoma Atractylodis Macrocephalae (parched with bran) decoction pieces; Radix Glycyrrhizae is cut into slices, and sheet is thick is 2 ~ 4mm, adopts processed with honey method to fry to yellow to buff, obtains Radix Glycyrrhizae decoction pieces;
Step 3: by Fructus Lycii, Fructus Mori, Fructus Schisandrae Chinensis removing impurity; Radix Rehmanniae, Radix Asparagi, Rhizoma Phragmitis, Poria, Radix Et Caulis Acanthopanacis Senticosi are cut into slices, and the thick 2 ~ 4mm of control strip obtains decoction pieces; Semen Ziziphi Spinosae, Semen Platycladi flatten to obtain decoction pieces, and Concha Ostreae grinding and sieving 80 ~ 100 order, obtains Concha Ostreae powder; Colla Corii Asini was pulverized 200 ~ 300 mesh sieves and was obtained Colla Corii Asini powder;
Step 4: by handle well Radix Rehmanniae, Radix Asparagi, Rhizoma Phragmitis, Poria, Fructus Lycii, Semen Ziziphi Spinosae, Semen Platycladi, the Rhizoma Atractylodis Macrocephalae, Poria, Fructus Schisandrae Chinensis, Fructus Mori, Concha Ostreae, licorice piece, mix, feed intake, extracting in water twice, add the water of medical material inventory 10 times for the first time, reflux, extract, 1.5h, second time adds 8 times of water gaging reflux, extract, 1h, merges after filtering and obtains extracting solution;
Step 5: add 5 times of water soakings two hours after being pulverized by Bulbus Lilii, filters, obtains extracting solution;
Step 6: combining step 4,5 extracting solution, is evaporated to relative density 1.05 ~ 1.07, add the Colla Corii Asini powder of preparation in step 3, after stirring and dissolving, spraying dry obtains xeraphium;
Step 7: after step 6 gained xeraphium is added correctives, dry granulation obtains granule, packs and get final product.Preferably, the method for acanthopanax senticosus saponins is extracted in described step 7 for the extraction that refluxed by organic solvent.
Preferably, in described step 6, the condition of concentrating under reduced pressure method is: pressure is 20 ~ 40KPa.
Preferably, in described step 6, spray drying condition is inlet temperature 160 ~ 180 DEG C, leaving air temp 80 ~ 95 DEG C.
Preferably, in described step 7, suspending agent is xanthan gum; Flavoring agent is Fructus Citri Limoniae essence, stevioside or sorbitol.
Radix Rehmanniae: property is sweet, cold.GUIXIN, liver, kidney channel.Radix Rehmanniae clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid.For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis sends out speckle dermexanthesis.
Bulbus Lilii: Bulbus Lilii is the dry meat scale leaf of liliaceous plant tiger lily or Lilium tenuifolium.Bulbus Lilii is conventional Chinese herbal medicine, and be the first batch of medicine-food two-purpose product that the examination & approval of China's Ministry of Public Health is passed through, its nutritional labeling mainly contains protein, starch, polysaccharide and inorganic salt etc., has good medical value.The traditional Chinese medical science is thought, Bulbus Lilii sweet and slightly bitter taste, and property is put down.Enter the heart, lung meridian.Have nourishing YIN and moistening the lung, the merit of clearing away heart-fire for tranquillization, can be used for deficiency of YIN cough caused by dryness, chronic cough hemoptysis, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, the diseases such as absentminded.Often use as monarch drug in the prescription that the traditional Chinese medical science is traditional, the lilii and Anemarrhenae Decoction (effect is mind tranquilizing and the heart calming, moistening lung and clearing heat) in such as " gold doctor outline ", lilii and Rehmanniae Decoction (effect be profit nourish heart lung, clearing away heat and cooling blood).In the life that our mouth is normal, Bulbus Lilii is dietetic therapy article conventional during our mouth is often lived, not only delicious, nutrition but also have good curative effect effect.
Radix Asparagi: this product is the dried root of liliaceous plant Radix Asparagi.Autumn, season in winter two excavate, and clean, and removing stem foot and fibrous root, put in boiling water and boil or steam to the saturating heart, remove crust while hot, cleaning, drying.Sweet, bitter, cold.Return lung, kidney channel nourishing YIN to relieve dryness, lung heat clearing is promoted the production of body fluid.For dryness of the lung dry cough, pertussis expectorant sticks, dry throat and mouth, dryness of the intestine constipation.
Rhizoma Phragmitis: this product is the fresh of grass phragmites communis or dry rhizome.The whole year all can excavate, removing bud, fibrous root and membranaceous leaf, using fresh herb or dry.Sweet, cold.Attach to the lung and stomach meridians.Clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Rhizoma Phragmitis one medicine, is mainly used in following two aspects clinically, can clearing away lung-heat and evacuation of pus of eliminating the phlegm, again can clearing away stomach-heat and the preventing or arresting vomiting that promotes the production of body fluid.Though its attribute is trembled with fear, slightly sweet flavor and power use lung heat clearing stomach, can only as auxiliary medicine.But, it has an advantage, and namely property is not grown greasy, promotes the production of body fluid and does not love heresy, and all epidemic febrile disease deep loves are defended, gas, or if any the syndrome that impairment of body fluid is thirsty after calentura, all can apply.
Colla Corii Asini: this product is that the skin of equine species donkey is through decocting, concentrating the solid gum made.Sweet, flat.Return lung, liver, kidney channel.To enrich blood YIN nourishing, moisturize, hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
Radix Et Caulis Acanthopanacis Senticosi: this product is the drying of Araliaceae Radix Et Caulis Acanthopanacis Senticosi, root and rhizome or stem.Return spleen, kidney, heart channel.Replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization.For deficiency of spleen-YANG and kidneyYANG, body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep.By the animal experiment study to Radix Et Caulis Acanthopanacis Senticosi main extract Radix Et Caulis Acanthopanacis Senticosi soap former times, though show that it is without directly causing sleep effect, has obvious hypnotic effect.
Fructus Lycii: the flat effect with the liver and the kidney tonifying of Fructus Lycii sweet in the mouth, property, cures mainly caused by liver and kidney deficiency, have a dizzy spell, visual unclear, soreness of the waist and knees, positive rash seminal emission, cough due to consumptive disease, taking fluids profusely of quenching one's thirst.Research display Long-term Oral Fructus Lycii powder can make the physical condition of older population significantly improve, and the situation of vexed insomnia has significance to improve.
Semen Ziziphi Spinosae: Semen Ziziphi Spinosae is the dry mature seed of Rhamnaceae plant Ziziphi Spinosae, Shennong's Herbal cloud " main vexatious insomnia ", is listed in top grade.Semen Ziziphi Spinosae nature and flavor are sweet, sour, flat, return liver, gallbladder, heart channel, have tonifying liver, mind calming, arresting sweating, promoting the production of body fluid effect, being used for the diseases such as restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the hyperhidrosis of body void, Tianjin wound be thirsty, is the tranquilizing soporific Chinese medicine comparatively commonly used.Semen Ziziphi Spinosae total saponins is the principle active component of Semen Ziziphi Spinosae.Related animal experiment finds: Semen Ziziphi Spinosae total saponins can reduce spontaneous activity in mice, and the central inhibitory action of collaborative pentobarbital sodium, the central excitation effect of antagonism amfetamine, has subliminal hypnosis sedation.
Semen Platycladi: this product is the dry mature kernal of Cupressaceae plant Cacumen Platycladi.Autumn, mature seed of gathering in season in winter two, dry, and removing seed coat, collects kernel.Sweet, flat.GUIXIN, kidney, large intestine channel.Tranquilizing by nourishing the heart, hidroschesis, intestine moistening.For fidgets due to deficiency insomnia, severe palpitation, night sweat due to yin deficiency, dryness of the intestine constipation.
The Rhizoma Atractylodis Macrocephalae: this product is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.Bitter, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Poria: Poria is the dry sclerotia that On Polyporaceae obtains Bodhisattva.Sweet in the mouth, light, property is put down.GUIXIN, lung, spleen, kidney channel.Function promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, just have loose bowels in the pool, irritability, palpitation with fear insomnia.China eats Poria, and oneself has bimillennial history, and Poria is classified as " top grade " by Shennong's Herbal, claims its " for a long time clothes peace soul is reposed, not hungry prolong life ".Poria is one of Chinese medicine " four monarch's eight delicacies ", and the main chemical compositions of Poria is pachyman.Chen Chunxia etc. study the syngignoscism of pachyman, experimental result shows, pachyman has syngignoscism, pachyman 100mg/ (kgd) continuously intraperitoneal administration 7d can strengthen the appropriate sodium of sulphuric acid to the suppression of mice maincenter, the time that mice righting reflex loss continues is 4.69 times of the appropriate sodium matched group of sulphuric acid, has statistical significance (P<0.05) with sulphuric acid appropriate sodium matched group comparing difference.
Fructus Schisandrae Chinensis: this product is the dry mature fruit of magnoliaceae schisandra schisandra chinensis.The former practises title " Radix Schisandrae Bicoloris ", and the latter practises title " Fructus Schisandrae Sphenantherae ".Pluck during fruit maturation in autumn, dry or dry after steaming, removing carpopodium and impurity.Sour, sweet, temperature.Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Fructus Mori: having another name called sorosis Fructus Mori before more than 2,000 years has been the hired tonic of Chinese emperors.Because the growing environment that mulberry is special makes sorosis have the feature of spontaneous growth without any pollution so Fructus Mori are otherwise known as " holy fruit among the people ".4 times of it contains the nutrient such as abundant activated protein, provitamin A, B1, B2, PP and C, aminoacid, malic acid, succinic acid, tartaric acid, carotene, mineral calcium, phosphorus, ferrum, copper, zinc to be 5 ~ 6 times of Fructus Mali pumilae be Fructus Vitis viniferae have multiple efficacies and are described as " the best health fruit of 21st century " by medical circle.Often eat Fructus Mori and can significantly improve effect that body immunity has slow down aging looks improving and the skin nourishing.Fructus Mori not only can food but also can be used as medicine, and the traditional Chinese medical science thinks Fructus Mori sweet in the mouth, acid, cold nature.Enter the heart, liver, kidney channel.For strengthening by means of tonics, the good fruit of the heart nourishing and intellengence improving.There is Yin-nourishing and body fluid promoting of enriching blood to quench the thirst the effects such as intestine moistening is dry, cure mainly deficiency of YIN-blood and cause tinnitus of having a dizzy spell, cardiopalmus, irritated insomnia, soreness of the waist and knees, early whitening of beard and hair, quench one's thirst, the disease such as xerostomia, constipation with dry stool.
Concha Ostreae: this product is the shell of the long Concha Ostreae of Ostreidae animal, Dalian Bay Concha Ostreae or Crassostrea rivularis.The whole year all can gather, fleshing, cleans, dries.Salty, be slightly cold.Return liver, gallbladder, kidney channel.Tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Traditional Chinese medical science compatibility theory:
Reusing Radix Rehmanniae, Bulbus Lilii nourishing YIN and clearing away heat in side, relieving restlessness of promoting the production of body fluid, is monarch drug.Radix Asparagi, the replenishing YIN and removing heat of Rhizoma Phragmitis principal drug assistance are ministerial drug.Colla Corii Asini, Radix Et Caulis Acanthopanacis Senticosi, Fructus Lycii benefiting QI and nourishing blood; Semen Ziziphi Spinosae, Semen Platycladi, Rhizoma Atractylodis Macrocephalae tranquilizing by nourishing the heart; Poria restoring normal coordination between the heart and kidney; Fructus Schisandrae Chinensis QI invigorating yin fluid astringing; Fructus Mori clear away heart-fire and invigorate blood circulation; Concha Ostreae tranquilizing mind, taking into account its mark, is adjuvant drug altogether.The sweet temperature QI invigorating of Radix Glycyrrhizae Preparata, and can coordinating the actions of various ingredients in a prescription, for making medicine.It is main that we's YIN nourishing is effected a permanent cure, and taking stopgap measures calms the nerves is auxiliary.
Detailed description of the invention
Be clearly and completely described the technical scheme in the embodiment of the present invention below, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiments provide a kind of solid beverage of improving water flood, raw material is prepared with parts by weight, is made up of Radix Rehmanniae 12 parts, Bulbus Lilii 12 parts, Radix Asparagi 9 parts, Rhizoma Phragmitis 20 parts, 5 parts, Colla Corii Asini, Radix Et Caulis Acanthopanacis Senticosi 9 parts, Fructus Lycii 9 parts, Semen Ziziphi Spinosae 9 parts, Semen Platycladi 9 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, 9 parts, Poria, Fructus Schisandrae Chinensis 9 parts, Fructus Mori 9 parts, Concha Ostreae 5 parts, 9 parts, Radix Glycyrrhizae.
In we, Radix Rehmanniae, Bulbus Lilii are monarch drug, also have lilii and Rehmanniae Decoction in ancient prescription, to nourish heart lung, clearing away heat and cooling blood because having profit, to reach the effect of eliminating heart-fire; Semen Ziziphi Spinosae, Semen Platycladi, the Rhizoma Atractylodis Macrocephalae have effect of tranquilizing by nourishing the heart, and the Rhizoma Atractylodis Macrocephalae can also coordinate the effect playing diuretic in addition, avoid the risk because of Semen Ziziphi Spinosae life-time service generation water-sodium retention; Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis share has hypnotic effect, at present, research Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis share the method for the rear sedative-hypnotic effect to mice, adopt above threshold with hypnosis of pentobarbital sodium of subthreshold dose method, research is compared to Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis sedative-hypnotic effect that is alone and that share.The method of application pentobarbital sodium induced mice sleep, the dose-effect relationship of research Radix Et Caulis Acanthopanacis Senticosi and the effect of Fructus Schisandrae Chinensis improving water flood.Result: Radix Et Caulis Acanthopanacis Senticosi can extend the length of one's sleep (P < 0.01), and effective dose is 16g/kg, and functioning window is 16 ~ 128g/kg, and when wherein dosage is 64g/kg, effect is the most remarkable.Fructus Schisandrae Chinensis can shorten Sleep latency (P < 0.05), and effective dose is 3g/kg, and functioning window is 3 ~ 12g/kg, and when wherein dosage is 12g/kg, effect is the most remarkable.Compared with blank group, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis combination group significantly can shorten the dropping asleep latency (P < 0.01) of pentobarbital sodium mice, and its length of one's sleep (P < 0.01) can be extended, obviously can increase the sleep rate (P < 0.05) of sub-threshold dose pentobarbital sodium mice, its effect is better than alone Radix Et Caulis Acanthopanacis Senticosi group and alone five tastes subgroup; Concha Ostreae, has effect of tranquilizing mind, but it does not have long-term taking as Cinnabaris easily to produce the danger of mercurialism, admittedly be in we first choice of tranquilizing mind.
Preparation process is as follows:
Step 1: prepare raw material by above-mentioned parts by weight;
Step 2: the Rhizoma Atractylodis Macrocephalae is cut into slices, the thick 2 ~ 4mm of control strip, fries to yellowish-brown with processed with honey Testa Tritici, takes out, and sieve removes processed with honey wheat bran, obtains Rhizoma Atractylodis Macrocephalae (parched with bran) decoction pieces; Radix Glycyrrhizae is cut into slices, and sheet is thick is 2 ~ 4mm, adopts processed with honey method to fry to yellow to buff, obtains Radix Glycyrrhizae decoction pieces;
Step 3: by Fructus Lycii, Fructus Mori, Fructus Schisandrae Chinensis removing impurity; Radix Rehmanniae, Radix Asparagi, Rhizoma Phragmitis, Poria, Radix Et Caulis Acanthopanacis Senticosi are cut into slices, and the thick 2 ~ 4mm of control strip obtains decoction pieces; Semen Ziziphi Spinosae, Semen Platycladi flatten to obtain decoction pieces, and Concha Ostreae grinding and sieving 80 ~ 100 order, obtains Concha Ostreae powder; Colla Corii Asini was pulverized 200 ~ 300 mesh sieves and was obtained Colla Corii Asini powder;
Step 4: by handle well Radix Rehmanniae, Radix Asparagi, Rhizoma Phragmitis, Poria, Fructus Lycii, Semen Ziziphi Spinosae, Semen Platycladi, the Rhizoma Atractylodis Macrocephalae, Poria, Fructus Schisandrae Chinensis, Fructus Mori, Concha Ostreae, licorice piece, mix, feed intake, extracting in water twice, add the water of medical material inventory 10 times for the first time, reflux, extract, 1.5h, second time adds 8 times of water gaging reflux, extract, 1h, merges after filtering and obtains extracting solution;
Step 5: add 5 times of water soakings two hours after being pulverized by Bulbus Lilii, filters, obtains extracting solution;
Step 6: combining step 4,5 extracting solution, is evaporated to relative density 1.05 ~ 1.07, add the Colla Corii Asini powder of preparation in step 3, after stirring and dissolving, spraying dry obtains xeraphium;
Step 7: after step 6 gained xeraphium is added correctives, dry granulation obtains granule, packs and get final product.
Preferably, in described step 6, the condition of concentrating under reduced pressure method is: pressure is 20 ~ 40KPa.
Preferably, in described step 6, spray drying condition is inlet temperature 160 ~ 180 DEG C, leaving air temp 80 ~ 95 DEG C.
Preferably, in described step 7, suspending agent is xanthan gum; Flavoring agent is Fructus Citri Limoniae essence, stevioside or sorbitol.
Animal experiment
Experiment one: the present invention is on the impact of sub-threshold dose pentobarbital sodium mouse sleep time
Experiment material
Medicine: by above-described embodiment and preparation method gained solid particle, add 100 ~ 200ml water before test and be made into solid beverage, stand-by.
Animal: Kunming mouse 40, body weight 20 ± 2g, male and female half and half, are divided into 2 groups at random, living environment and feeding patterns identical, the continuous gavage solid beverage of experimental group 7 days, 1h after last administration, 40 mouse peritoneals inject 1% concentration pentobarbital sodium 50mg/kg, record each Mus sleep quality, statistical procedures adopts X 2 test, the results are shown in Table 1.
Table 1:
Can find out that the solid beverage that the present invention proposes has the length of one's sleep significantly increasing sub-threshold dose pentobarbital sodium mice by table 1 data.
Experiment 2: the present invention is to mice sleep quality influence
Experiment method:
Medicine: by above-described embodiment and preparation method gained solid particle, add 100 ~ 200ml water before test and be made into solid beverage, stand-by.
Animal: Kunming mouse 40, body weight 20 ± 2g, male and female half and half, be divided into 2 groups at random, living environment and feeding patterns identical, the continuous gavage solid beverage of experimental group 7 days, during mice sleep, carry out light wake up with a start experiment, suddenly turned on light one minute at interval of one hour, observe mice with or without waking up with a start, result is as table 2.
Table 2:
Can find out that the solid beverage that the present invention proposes has the effect improving mice sleep quality by table 2 data.
Experiment three: the present invention on internal organs with or without impact
Experiment method
By the Kunming mouse sacrificed by decapitation in experiment one, core, liver, spleen, lung, kidney, brain, adrenal gland, ovary, uterus, testis, attachedly to start, lymph node, fix with 10% formalin solution, specimens paraffin embedding slices, with hematoxylin eosin stain, the change of microscopic examination tissue morphology, the results are shown in Table 3 and table 4.
Table 3:
Table 4:
Can be found out by table 3 and table 4 data and to compare with matched group, the microscopy results of each internal organs section, each anatomical feature has no significant change, and shows that the solid beverage that the present invention proposes is nontoxic.
Clinical experiment:
Case 1:
State of an illness brief abstract: 45 years old Lee in Fengtai district of Beijing, male, over the past two years because operating pressure is large, easily wake up and dreaminess in the middle of difficulty falling asleep, sleep, sleep quality was low, and vexed easy random, fatigue and weak, continue to take sleeping pill 1.5 years, period, go to a doctor at various big hospital, hospital diagnosis is anxiety neurosis, takes all kinds of Chinese medicine and western medicine and is showed no and is clearly better.The solid beverage of the improving water flood that the present invention proposes is taken on May 7th, 2014, often per day 5 solid beverages of taking after mixing it with water, after three days, sleeper effect is improved, to have clear improvement after seven days and memory take a favorable turn, fall asleep again without hell and high water after taking January, also easily do not wake up in the middle of sleep symptom, period, life, food environment were with in the past without changing greatly without taking other drug.
Case 2:
State of an illness brief abstract: 50 years old Mrs Liu in Shijiazhuang District, Hebei, insomnia and dreamful sleep 5 years, do not take sleeping pill and can not fall asleep 3 years, angel, diet is poor, and build is become thin, frequent loose stool.Take the solid beverage of the improving water flood that the present invention proposes on January 15th, 2013, often per day 7 solid beverages of taking after mixing it with water, had outstanding effect after seven days, and appetite is compared with the past has increased 1/4th, and stool is shaped; After taking first quarter moon, sleeper effect takes a turn for the better, and expression takes a turn for the better; Take one month, body weight comparatively increased by 1 kilogram before the moon, sleep no problem; The bimester of taking, heavy body increases by 2.1 kilograms, and expression is normal, and stool recovery is normal, and period, life, food environment were with changing without large in the past without taking other drug.
Case 3:
State of an illness brief abstract: zhengding county Middle School Students, 18 years old, a nearly aypnia dreaminess, often suffered from diarrhoea, and xerostomia is without bitter taste, and Chang Youwu reason is vexed, pale tongue yellow fur, stringy and thready pulse.Take the solid beverage of the improving water flood that the present invention proposes April 3 in 2015, often per day 4 solid beverages of taking after mixing it with water, disease is clearly better two days later; Take sleep quality after five days to recover, the mental status is good, without diarrhoea; Take after ten days that health is without any discomfort, tongue fur is normal, pulse is strong, and period, life, food environment were with in the past without changing greatly without taking other drug.
Can be shown by above-mentioned zoopery and clinical case, 1, the solid beverage of improving water flood proposed by the invention has the effect of good improving water flood, particularly has very high therapeutic effect to the burnt symptom of drawing due to work and school work; 2, the present invention proposes to take mode with drink form, and what greatly facilitate patient takes mode, achieves the theory of Chinese medical science of " supporting slowly "; 3, the present invention proposes solid beverage and definitely has no side effect.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.