CN103432390A - Medicament for treating coronary heart disease and preparation method thereof - Google Patents
Medicament for treating coronary heart disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicament for treating coronary heart disease and a preparation method thereof. The medicament is mainly prepared from astragalus root, prepared rehmannia root, radix polygonati officinalis, radix codonopsitis, tuckahoe, Chinese yam, ligusticum wallichii, radix bupleuri, costus root and other drugs according to certain weight ratios. The medicament has functions of activating blood circulation to stimulate meridians, calming the mind and nerves and tonifying middle-jiao and qi, and is used for treating coronary heart disease which can not relapse after cure.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of coronary heart disease and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Coronary heart disease is called for short coronary heart disease.Finger is because lipid metabolism is undesired, and the lipid calmness in blood, on the endarterium of otherwise smooth, is piled up and formed white speckle at the lipid material of some similar medicated porridge samples of endarterium, is called atherosclerotic lesion.These specklees gradually increase and cause lumen of artery narrow, and blood flow is obstructed, and cause heart ischemia, produce angina pectoris.At present, western medicine coronary heart disease poor effect, and more side effect is arranged, therefore, there is very large demand in people to the Chinese medicine of rapid, effective treatment coronary heart disease.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment coronary heart disease, thereby has completed the present invention.
Purpose of the present invention just is to provide a kind of composition of medicine that can effectively treat coronary heart disease.
Another object of the present invention just has been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Pericarpium Citri Reticulatae, the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Polygonati Odorati, Radix Codonopsis, Poria, Rhizoma Dioscoreae, Rhizoma Chuanxiong, Radix Bupleuri, the Radix Aucklandiae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Flos Carthami, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Adenophorae, Semen Persicae, Radix Ophiopogonis, Ramulus Cinnamomi, Fructus Schisandrae Chinensis medicine to be combined, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the coronary disease palindromia.Wherein select Pericarpium Citri Reticulatae to be because its nature and flavor are bitter, hot, temperature, return lung, spleen channel, and regulating qi-flowing for strengthening spleen is arranged, and the function of drying dampness to eliminate phlegm, control fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Select the Radix Astragali to be because its nature and flavor are sweet, tepor, enter lung, spleen channel, give birth to the useful consolidating superficial resistance of defending, and inducing diuresis to remove edema, poison holding, the function of granulation promoting, control spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle is not burst or is burst and hold back for a long time; Process by the function that the invigorating middle warmer benefit is arranged, control the internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor, enter liver, kidney channel, and YIN nourishing is arranged, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, the waist knee flaccidity, and the chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia, quench one's thirst, frequency of micturition, deafness, blurred vision.Select Rhizoma Polygonati Odorati to be because its nature and flavor are sweet, flat, enter lung, the stomach warp, have yin nourishing, moisturizes, relieving restlessness, the function of quenching the thirst, control calentura sun wound, cough, excessive thirst, deficient fever, rapid digestion of food is easily hungry, frequent micturition.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, the meridian of Foot-TAI YIN edema caused by disorder of QI, invigorating the spleen and replenishing QI is arranged, the function of promoting the production of body fluid, control weakness of the spleen and stomach, deficiency of both QI and blood, and fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, eliminating dampness and diuresis is arranged, the strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting, have loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select Rhizoma Dioscoreae to be because its nature and flavor are sweet, flat, enter lung, spleen, kidney channel, spleen invigorating is arranged, tonifying the lung, reinforce the kidney, and the function of benefit essence, control diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease, quench one's thirst, seminal emission, leukorrhagia, frequent micturition.Selecting Rhizoma Chuanxiong is because its nature and flavor suffering, and temperature, enter liver, gallbladder meridian, and activating QI to alleviate the depression is arranged, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Select Radix Bupleuri to be because its nature and flavor hardship is cool, enter liver, gallbladder meridian, reconciling superficies and interior is arranged, soothing the liver, the function of yang invigorating, control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste deafness, headache and dizziness, malaria, diarrhea proctoptosis, menoxenia, uterine prolapse.Select the Radix Aucklandiae to be because its nature and flavor are arduous, temperature, enter lung, liver, spleen channel, and promoting the circulation of QI to relieve pain are arranged, and the function of warming middle-JIAO for easing the stomach is controlled the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain, and vomiting, have loose bowels, dysentery tenesmus, colic of cold type.Select Radix Rehmanniae to be because its nature and flavor are sweet, cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, and the function of promoting the production of body fluid, control the calentura excessive thirst, yin asthenia generating intrinsic heat, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis, send out the speckle dermexanthesis.Select Radix Paeoniae Rubra to be because its nature and flavor hardship is slightly cold, return Liver Channel, clearing away heat and cooling blood is arranged, the function of eliminating stasis to stop pain, control warm poison and go mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， Epilepsy abdominal mass stomachache, injury from falling down, carbuncle skin infection.Selecting Fructus Aurantii is because its nature and flavor toil, cool, enters lung, spleen, large intestine channel, and dispelling the stagnated QI is arranged, row expectorant, the function of removing food stagnancy, control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.Selecting Flos Carthami is that temperature, enter the heart, Liver Channel, and promoting blood circulation to restore menstrual flow is arranged because of its nature and flavor suffering, and the function of blood stasis removing pain relieving is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Selecting Radix Salviae Miltiorrhizae is that tepor, enter the heart, Liver Channel, and blood circulation and promoting silt is arranged because of its nature and flavor hardship, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving, control angina cordis, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen, gather, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm enters the heart, liver, spleen channel, benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, the dryness of the intestine difficulty just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Radix Adenophorae to be because its property sweet and slightly bitter taste is cool, enter lung, Liver Channel, nourishing YIN and clearing away lung-heat is arranged, the function of expelling phlegm for arresting cough, control lung-heat type cough, the chronic consumptive disease chronic cough, and the moon is hindered the dry pharynx laryngalgia.Select Semen Persicae to be because its property bitter but sweet flavor is flat, enter the heart, liver, large intestine channel, blood stasis removing and clots absorbing is arranged, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select be Radix Ophiopogonis because its property sweet and slightly bitter taste is cold, enter lung, stomach, heart channel, nourishing YIN and moistening the lung is arranged, the relieving restlessness that clears away heart-fire, the function of reinforcing stomach reg fluid, control dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation, clear thirsty, calentura Tianjin wound, dry mouth and throat, constipation.Selecting Ramulus Cinnamomi is that temperature, enter bladder, the heart, lung meridian, and the diaphoresis expelling pathogenic factors from muscles is arranged because of its property acrid-sweet flavor, and the function of warming the meridian and promoting blood circulation, control exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Selecting Fructus Schisandrae Chinensis is that temperature, enter lung, kidney channel, astringes the lung because of its nature and flavor acid, and nourishing kidney, promote the production of body fluid, and receives antiperspirant, and the function of arresting seminal emission, control the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.
The drug dose of the present invention's combination is also that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope
Pericarpium Citri Reticulatae 8-15 gram Radix Astragali 8-15 gram Radix Rehmanniae Preparata 8-15 gram
Rhizoma Polygonati Odorati 8-15 gram Radix Codonopsis 8-15 gram Poria 8-15 gram
Rhizoma Dioscoreae 10-20 gram Rhizoma Chuanxiong 15-25 gram Radix Bupleuri 10-20 gram
Radix Aucklandiae 8-15 gram Radix Rehmanniae 8-12 gram Radix Paeoniae Rubra 8-12 gram
Fructus Aurantii 10-20 gram Flos Carthami 10-20 gram Radix Salviae Miltiorrhizae 8-12 gram
Radix Angelicae Sinensis 15-25 gram Radix Adenophorae 8-15 gram Semen Persicae 8-15 gram
Radix Ophiopogonis 8-15 gram Ramulus Cinnamomi 15-25 gram Fructus Schisandrae Chinensis 10-20 gram
Preferable amount is
The Pericarpium Citri Reticulatae 10 gram Radix Astragali 10 gram Radix Rehmanniae Preparata 10 grams
Rhizoma Polygonati Odorati 10 gram Radix Codonopsis 10 gram Poria 10 grams
Rhizoma Dioscoreae 15 gram Rhizoma Chuanxiong 20 gram Radix Bupleuri 15 grams
The Radix Aucklandiae 10 gram Radix Rehmanniae 9 gram Radix Paeoniae Rubra 9 grams
Fructus Aurantii 15 gram Flos Carthami 15 gram Radix Salviae Miltiorrhizae 9 grams
Radix Angelicae Sinensis 20 gram Radix Adenophorae 10 gram Semen Persicae 10 grams
Radix Ophiopogonis 10 gram Ramulus Cinnamomi 20 gram Fructus Schisandrae Chinensis 15 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, softens, and shredding, dry or cold drying, sieve dedust bits;
2, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water;
3, Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata to get final product;
4, Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section, dry;
5, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;
6, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
7, Rhizoma Dioscoreae: choose clean impurity, be soaked in water to the Rhizoma Dioscoreae central part soften for the degree, pull out slightly and dry in the air, the section dry or dry;
8, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, after moistening, cuts into slices, and drying;
9, Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry immediately;
10, the Radix Aucklandiae: crude drug in whole is put in clear water and cleaned, pull out, moistening makes soft in 12-24 hours, and section, dry;
11, Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit, cut sheet, drying, and sieve removes chip;
12, Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping, clean, runs through, and shave, drying, sieve removes chip;
13, Fructus Aurantii: remove flesh, core, edulcoration, slightly soak, and pulls out, softens, and section, dry;
14, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
15, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
16, Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dry in the air when suitable to inside and outside humidity, and section is dried;
17, Radix Adenophorae: choose clean impurity, go reed, wash, slightly profit, cut into slices, and well sifted dries;
18, Semen Persicae: remove duricrust impurity, put in the boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove kind of a skin, dry, winnow with a dustpan clean;
19, Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, after running through, pump the heart, then clean and dry;
20, Ramulus Cinnamomi: water slightly soaks, and pulls out, and moistening, to thoroughly, is cut into slices, and dries, and sieves anti-dandruff;
21, Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried.
Two, preparation
1, the Pericarpium Citri Reticulatae of described weight, the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Polygonati Odorati, Radix Codonopsis, Poria, Rhizoma Dioscoreae, Rhizoma Chuanxiong, Radix Bupleuri, the Radix Aucklandiae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Flos Carthami, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Adenophorae, Semen Persicae, Radix Ophiopogonis, Ramulus Cinnamomi, Fructus Schisandrae Chinensis medicine are decocted with water to secondary, adding for the first time 6 times of water gagings is soaked, soak after 180 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 20 minutes, filter to obtain decoction liquor for the first time.
2, the medicinal residues of filtration are added to 3 times of amounts of water, intense fire decocts boiling 10 minutes, then uses slow fire boiling 20 minutes, filters to obtain decoction liquor for the second time.
3, merge decoction liquor twice, intense fire boils, then with slow fire boiling 10 minutes and get final product, and will decoct medicinal liquid and be divided into 6 doses and take.
Medicine of the present invention has promoting blood circulation to restore menstrual flow, calming heart and tranquilizing mind, and the effect of invigorating the spleen and replenishing QI, be used for the treatment of coronary heart disease, short treating period, instant effect, non-relapse after healing, has no side effect.
The specific embodiment
Below further set forth the beneficial effect of medicine of the present invention by test example, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 30 of rabbit, the male and female dual-purpose, body weight 2.0-2.2kg, divide two groups, and 15 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, and every day, secondary, serve on 7 days, observes the administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] Drug therapy coronary heart disease of the present invention
1, physical data
Accept out-patient's totally 150 examples for medical treatment, its male patient's 90 examples, female patient 60 examples.
2, diagnostic criteria
The coronary heart disease clinical manifestation
Clinical conceal type, angina pectoris, myocardial infarction type, heart failure type (ischemic cardiomyopathy), five types of sudden death type of being divided into.Wherein modal is angina pectoris, and the most serious is myocardial infarction and dies suddenly two types.
Angina pectoris be one group due to acute temporary myocardial ischemia, syndrome that anoxia rose:
(1) chest compressing sensation of asphyxia, vexed swollen sense, the violent sample pain of burning, general pain continues 1-5 minute, and occasionally have and reach 15 minutes, but spontaneous remission;
(2) pain often is radiated to left shoulder, the front inboard of left arm until little finger of toe and the third finger;
(3) pain for example, occurred in heart burden (physical exertion increases, excessive direct stimulation and catch cold) time, have a rest or sublingual administration nitroglycerin number minute after can disappear;
(4) pain when outbreak, can be with (also can without) collapse, perspiration, short of breath, worry, cardiopalmus, feel sick or dizzy symptom.
Myocardial infarction is the critical disease of coronary heart disease, usually has angina pectoris attacks frequent and increase the weight of as basis more, also has or not History of angina pectoris and the case of the myocardial infarction that happens suddenly (this kind of situation is the most dangerous, and Chang Yin does not guard against and causes sudden death).Showing as of myocardial infarction:
(1), after when burst breastbone or pareordia severe pain, shoulder, left arm or elsewhere radiation left, and pain is more than lasting half an hour, through having a rest and the buccal nitroglycerin can not be alleviated;
(2) short of breath, dizziness, feel sick, hyperhidrosis, pulse be trickle;
(3) clammy, greyish white, the severe disease sickly complexion of skin;
(4) unique performance of about 1/10th patient is faint or suffer a shock.
3, Therapeutic Method
Select above-mentioned medicament, take to the patient, each serving with 1 dose, every day, early, middle and late respectively the clothes 1 time, 20 days be a course for the treatment of, takes continuously 4 courses for the treatment of.
4, efficacy assessment standard
Produce effects: coronary heart disease symptom disappears, and it is normal that body constitution is recovered, and observes half a year without the recidivist;
Take a turn for the better: coronary heart disease symptom is clearly better, and body constitution is progressively recovered;
Invalid: as not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy patients with coronary heart disease 150 examples of the present invention, produce effects 145 examples as a result, obvious effective rate is 96.67%, 3 examples that take a turn for the better, improvement rate is 2%, invalid 2 examples, total effective rate is 98.67%.
Claims (3)
1. a medicine for the treatment of coronary heart disease, it is characterized in that: it is to be made by the crude drug in following weight range:
Pericarpium Citri Reticulatae 8-15 gram Radix Astragali 8-15 gram Radix Rehmanniae Preparata 8-15 gram
Rhizoma Polygonati Odorati 8-15 gram Radix Codonopsis 8-15 gram Poria 8-15 gram
Rhizoma Dioscoreae 10-20 gram Rhizoma Chuanxiong 15-25 gram Radix Bupleuri 10-20 gram
Radix Aucklandiae 8-15 gram Radix Rehmanniae 8-12 gram Radix Paeoniae Rubra 8-12 gram
Fructus Aurantii 10-20 gram Flos Carthami 10-20 gram Radix Salviae Miltiorrhizae 8-12 gram
Radix Angelicae Sinensis 15-25 gram Radix Adenophorae 8-15 gram Semen Persicae 8-15 gram
Radix Ophiopogonis 8-15 gram Ramulus Cinnamomi 15-25 gram Fructus Schisandrae Chinensis 10-20 gram.
2. external used medicine according to claim 1, wherein the consumption of each crude drug is:
The Pericarpium Citri Reticulatae 10 gram Radix Astragali 10 gram Radix Rehmanniae Preparata 10 grams
Rhizoma Polygonati Odorati 10 gram Radix Codonopsis 10 gram Poria 10 grams
Rhizoma Dioscoreae 15 gram Rhizoma Chuanxiong 20 gram Radix Bupleuri 15 grams
The Radix Aucklandiae 10 gram Radix Rehmanniae 9 gram Radix Paeoniae Rubra 9 grams
Fructus Aurantii 15 gram Flos Carthami 15 gram Radix Salviae Miltiorrhizae 9 grams
Radix Angelicae Sinensis 20 gram Radix Adenophorae 10 gram Semen Persicae 10 grams
Radix Ophiopogonis 10 gram Ramulus Cinnamomi 20 gram Fructus Schisandrae Chinensis 15 grams.
3. according to the preparation method of claim 1 or 2 described medicine, it comprises the following steps:
(1) get the raw materials ready
(1) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, softens, and shredding, dry or cold drying, sieve dedust bits;
(2) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water;
(3) Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata to get final product;
(4) Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section, dry;
(5) Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;
(6) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
(7) Rhizoma Dioscoreae: choose clean impurity, be soaked in water to the Rhizoma Dioscoreae central part soften for the degree, pull out slightly and dry in the air, the section dry or dry;
(8) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, after moistening, cuts into slices, and drying;
(9) Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry immediately;
(10) Radix Aucklandiae: crude drug in whole is put in clear water and cleaned, pull out, moistening makes soft in 12-24 hours, and section, dry;
(11) Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit, cut sheet, drying, and sieve removes chip;
(12) Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping, clean, runs through, and shave, drying, sieve removes chip;
(13) Fructus Aurantii: remove flesh, core, edulcoration, slightly soak, and pulls out, softens, and section, dry;
(14) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
(15) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
(16) Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dry in the air when suitable to inside and outside humidity, and section is dried;
(17) Radix Adenophorae: choose clean impurity, go reed, wash, slightly profit, cut into slices, and well sifted dries;
(18) Semen Persicae: remove duricrust impurity, put in the boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove kind of a skin, dry, winnow with a dustpan clean;
(19) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, after running through, pump the heart, then clean and dry;
(20) Ramulus Cinnamomi: water slightly soaks, and pulls out, and moistening, to thoroughly, is cut into slices, and dries, and sieves anti-dandruff;
(21) Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;
(2) preparation
(1) Pericarpium Citri Reticulatae of described weight, the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Polygonati Odorati, Radix Codonopsis, Poria, Rhizoma Dioscoreae, Rhizoma Chuanxiong, Radix Bupleuri, the Radix Aucklandiae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Flos Carthami, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Adenophorae, Semen Persicae, Radix Ophiopogonis, Ramulus Cinnamomi, Fructus Schisandrae Chinensis medicine are decocted with water to secondary, adding for the first time 6 times of water gagings is soaked, soak after 180 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 20 minutes, filter to obtain decoction liquor for the first time;
(2) medicinal residues of filtration are added to 3 times of amounts of water, intense fire decocts boiling 10 minutes, then uses slow fire boiling 20 minutes, filters to obtain decoction liquor for the second time;
(3) merge decoction liquor twice, intense fire boils, then with slow fire boiling 10 minutes and get final product, and will decoct medicinal liquid and be divided into 6 doses and take.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
-
2013
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
Non-Patent Citations (1)
| Title |
|---|
| 夏晨笑: "肝失疏泄导致冠心病心脉瘀滞的证治探讨", 《浙江中医杂志》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105250657A (en) * | 2015-11-12 | 2016-01-20 | 济南大学 | Medicine composition for treating atherosclerosis and preparation method thereof |
| CN105311538A (en) * | 2015-11-21 | 2016-02-10 | 戴淑娟 | Traditional Chinese medicine for treating cardiac insufficiency and fabrication method |
| CN106492125A (en) * | 2016-12-09 | 2017-03-15 | 冉兆斌 | A kind of treat medicine of coronary heart disease and preparation method thereof |
| CN106540142A (en) * | 2017-01-20 | 2017-03-29 | 季益林 | It is a kind of to prevent cardiopathic compound preparation and preparation method thereof |
| CN110025725A (en) * | 2019-06-04 | 2019-07-19 | 吕峰展 | It is a kind of to treat cardiopathic drug and preparation method thereof |
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|---|---|
| CN103432390B (en) | 2015-04-08 |
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