CN103948904A

CN103948904A - Medicine for treating wind-phlegm stasis type vertiginous epilepsy and preparation method thereof

Info

Publication number: CN103948904A
Application number: CN201410215188.1A
Authority: CN
Inventors: 高磊
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-05-21
Filing date: 2014-05-21
Publication date: 2014-07-30

Abstract

The invention discloses a medicine for treating wind-phlegm stasis type vertiginous epilepsy and a preparation method thereof. The medicine comprises the following raw medicinal materials: dried tangerine or orange peel, uncaria laevigata, dragonfly, cortex juglandis mandshuricae, rose, armeniaca mume, buckeye, persimmon calyx, semen brassicae, the root of red-rooted salvia, inula flower, bamboo juice, tabasheer, seaweed, kelp, concha meretricis sea cyclinae, ternate buttercup root, trichosanthes kirilowii Maxim, mellea armillaria sporophore, black sesame, folium rhododendri daurici, honeysuckle, uncaria, pearl, gastrodia elata, earthworm, stiff silkworm, rhizoma acori graminei, fresh ginger, ampelopsis cantoniensis and calystegia hederacea. The medicine has the beneficial effects that the method is based on the traditional theory of traditional Chinese medicine in China, has the main effects of eliminating phlegm and dredging, dispelling wind and relieving convulsion, is used for treating the wind-phlegm stasis type vertiginous epilepsy and has the advantages that the medicine is fast in effectiveness, exact in curative effect and high safety and does not have any toxic or side effect, and the disease is not easy to reoccur.

Description

Be used for the treatment of medicine of wind-phlegm resistance closed form epilepsia vertiginosa disease and preparation method thereof

Technical field

The present invention relates to pharmaceutical technology, relate in particular to a kind of Chinese medicine and preparation method for the treatment of qi stagnation and blood stasis type prolapse of lumbar intervertebral disc.

Background technology

Epilepsy is the of short duration brain function imbalance of chronic repeated relapsing syndrome.The brain neuron paradoxical discharge of take causes that repeatedly epilepsy outbreak is as feature.Epilepsy is one of nervous system common disease, and prevalence is only second to apoplexy.The sickness rate of epilepsy is relevant with the age.It is the highest with interior prevalence to it is generally acknowledged 1 years old, is secondly to reduce gradually for 1～10 years old later.China men and women's ratio is 1.15: 1～1.7: 1.Race's prevalence no significant difference.

Epilepsia vertiginosa disease is one of numerous outbreak kinds of epileptics, be all mostly the episodic vertigo that occurs suddenly, suddenly disappears be main clinical manifestation, main manifestations is that body moves sense and surrounding object sense of rotation, patient feels that unstable, the top-heavy or body of posture is to lopsidedness, can accompany pale complexion, perspiration, feel sick, the vegetative nerve symptom such as vomiting, indivedual patients also have the symptom of stomachache, also may occur the situations such as drowsiness, unable, headache after outbreak.

Vertiginous type epileptic realizes many without obvious obstacle, and rare grand mal, how without urinary incontinence, can show moment can not move or speech, generally without nystagmus.As merge automatism, independently do not chew, face is twitched, head eye turns to a side, and haziness, prompts for the psychomotor seizure that temporal lesion causes.Outbreak lasts of short duration conventionally, continues the several seconds to several minutes.Outbreak is many without obvious inducement and tendency, and paresthesia epilepsy and position are irrelevant.Neurologic check is normal.Electroencephalogram has characteristic to change, and is paroxysmal sharp wave, spike, the slow complex wave of sour jujube or the granting of paroxysmal high-voltage slow wave, especially take temporal lobe as main.

Chinese medicine thinks, vertiginous type epilepsy belongs to the categories such as motherland's medical science " epilepsy is sick ".Epilepsy disease is by congenital or acquired disposition, makes internal organs injured, and refreshing machine is impaired, god is out of control caused in unit, with sudden loss of consciousness, send out and fall forward, syncope, the eyes turning upwards, slobbering, tic of the limbs, or shout strangely in mouth, while moving, revive, a kind of paroxysmal disease that is main clinical manifestation just like ordinary person after waking up.Be called again " epilepsy syndrome ", " epilepsy ", " epilepsy " etc.From neonate to old age, all can fall ill.

The cause of disease of primary disease can be divided into congenital factors and acquired disposition.Congenital factors has two aspects, the one, nausea is impaired, when at female abdomen, mother or frightened and smart but, or overwork and body void causes children's's innate deficiency.The 2nd, father and mother's natural endowment weakness or Parent are suffered from epilepsy and are caused little vital essence not enough.Acquired disposition mainly contains three aspects:: the one, and incoordination of seven emotions; The 2nd, due to diseases caused by exogenous pathogenic factor six climate exopathogens, though often pathogenic factor goes and epilepsy syndrome solely stays, do not heal for a long time; The 3rd, tumbling down damage, retained epilepsy in blood stasis.

Differentiation of symptoms and signs for classification of syndrome is: YANG epilepsy type, epilepsy of YIN type type, phlegm-fire are disturbed refreshing type, type of wind-phlegm blocking, Qi deficiency blood stasis type, type of deficiency of both the heart and spleen, liver-kidney yin deficiency, and to be wherein that premorbid has more dizzy, uncomfortable in chest for the symptom of type of wind-phlegm blocking, weak, abundant expectoration, mood is unhappy, pale tongue, tongue is greasy in vain, and the many stringy and rolling pulse of arteries and veins are strong.

At present, western medical treatment vertiginous type epilepsy has more side effect, to body, causes certain untoward reaction etc., for example, can cause headache during larger dose, feel sick, vomiting, and fatigue, attention laxes, hypomnesis, mood change etc.; Can cause allergic reaction, occur erythra, liver toxicity, the reactions such as leukocyte or thrombocytopenia break with tremendous force, and imprevision endangers heavier; And prolonged application antiepileptic may produce teratogenesis, cause offspring to grow undesired etc.New Drug therapy epilepsy is wanted in clinical market in urgent need, to reduce toxic and side effects, reduces sickness rate, improves patient's quality of life etc.

Summary of the invention

Technical problem to be solved by this invention is, a kind of medicine for the treatment of wind-phlegm resistance closed form epilepsia vertiginosa disease and preparation method thereof is provided, this medicine take waking up the patient from unconsciousness by clearing away phlegm, endogenous wind stopping is relieving convulsion as main, that treatment wind-phlegm resistance closed form epilepsia vertiginosa disease has is rapid-action, determined curative effect, safe, the advantage that has no side effect and be difficult for recurring.

In order to solve the problems of the technologies described above, the invention provides a kind of medicine that is used for the treatment of wind-phlegm resistance closed form epilepsia vertiginosa disease, wherein, comprise following raw medicinal material: Pericarpium Citri Reticulatae, Uncaria tonkinensis Havil., Aeschna melanictera, Cortex Juglandis mandshuricae, Flos Rosae Rugosae, FLOS MUME, Semen Aesculi, Calyx Kaki, Semen Sinapis Albae, Radix Salviae Miltiorrhizae, Flos Inulae, Succus Bambusae, Concretio Silicea Bambusae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Concha Meretricis seu Cyclinae, Radix Ranunculi Ternati, Fructus Trichosanthis, Armillariella mellea, Semen Sesami Nigrum, Folium Rhododendri Daurici, Flos Lonicerae, Ramulus Uncariae Cum Uncis, Margarita, Rhizoma Gastrodiae, Pheretima, Bombyx Batryticatus, Rhizoma Acori Graminei, Rhizoma Zingiberis Recens, Folium hydrangeae strigosae rattan and DAWANHUA.

In described medicine, the parts by weight of each raw medicinal material are preferably: Pericarpium Citri Reticulatae 10-25 weight portion, Uncaria tonkinensis Havil. 10-20 weight portion, Aeschna melanictera 10-20 weight portion, Cortex Juglandis mandshuricae 10-20 weight portion, Flos Rosae Rugosae 15-25 weight portion, FLOS MUME 10-15 weight portion, Semen Aesculi 10-20 weight portion, Calyx Kaki 15-20 weight portion, Semen Sinapis Albae 10-20 weight portion, Radix Salviae Miltiorrhizae 10-20 weight portion, Flos Inulae 10-15 weight portion, Succus Bambusae 15-20 weight portion, Concretio Silicea Bambusae 15-20 weight portion, Sargassum 15-20 weight portion, Thallus Laminariae (Thallus Eckloniae) 10-15 weight portion, Concha Meretricis seu Cyclinae 10-15 weight portion, Radix Ranunculi Ternati 10-20 weight portion, Fructus Trichosanthis 10-20 weight portion, Armillariella mellea 10-20 weight portion, Semen Sesami Nigrum 5-10 weight portion, Folium Rhododendri Daurici 10-15 weight portion, Flos Lonicerae 10-15 weight portion, Ramulus Uncariae Cum Uncis 10-20 weight portion, Margarita 10-20 weight portion, Rhizoma Gastrodiae 10-15 weight portion, Pheretima 10-15 weight portion, Bombyx Batryticatus 15-25 weight portion, Rhizoma Acori Graminei 10-20 weight portion, Rhizoma Zingiberis Recens 15-20 weight portion, Folium hydrangeae strigosae rattan 10-20 weight portion and DAWANHUA 10-20 weight portion.

In described medicine, the parts by weight of each raw medicinal material can also be preferably: Pericarpium Citri Reticulatae 18 weight portions, Uncaria tonkinensis Havil. 15 weight portions, Aeschna melanictera 15 weight portions, Cortex Juglandis mandshuricae 15 weight portions, Flos Rosae Rugosae 19 weight portions, FLOS MUME 12 weight portions, Semen Aesculi 15 weight portions, Calyx Kaki 17 weight portions, Semen Sinapis Albae 15 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Flos Inulae 12 weight portions, Succus Bambusae 17 weight portions, Concretio Silicea Bambusae 18 weight portions, Sargassum 18 weight portions, Thallus Laminariae (Thallus Eckloniae) 12 weight portions, Concha Meretricis seu Cyclinae 12 weight portions, Radix Ranunculi Ternati 15 weight portions, Fructus Trichosanthis 15 weight portions, Armillariella mellea 15 weight portions, Semen Sesami Nigrum 12 weight portions, Folium Rhododendri Daurici 12 weight portions, Flos Lonicerae 14 weight portions, Ramulus Uncariae Cum Uncis 15 weight portions, Margarita 15 weight portions, Rhizoma Gastrodiae 12 weight portions, Pheretima 12 weight portions, Bombyx Batryticatus 21 weight portions, Rhizoma Acori Graminei 15 weight portions, Rhizoma Zingiberis Recens 19 weight portions, Folium hydrangeae strigosae rattan 15 weight portions and DAWANHUA 15 weight portions.

Described medicine also comprises: Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata, Rhizoma Dioscoreae, Cortex Magnoliae Officinalis and Fructus Jujubae.

In described medicine, the parts by weight of each raw medicinal material are preferably: Pericarpium Citri Reticulatae 10-25 weight portion, Uncaria tonkinensis Havil. 10-20 weight portion, Aeschna melanictera 10-20 weight portion, Cortex Juglandis mandshuricae 10-20 weight portion, Flos Rosae Rugosae 15-25 weight portion, FLOS MUME 10-15 weight portion, Semen Aesculi 10-20 weight portion, Calyx Kaki 15-20 weight portion, Semen Sinapis Albae 10-20 weight portion, Radix Salviae Miltiorrhizae 10-20 weight portion, Flos Inulae 10-15 weight portion, Succus Bambusae 15-20 weight portion, Concretio Silicea Bambusae 15-20 weight portion, Sargassum 15-20 weight portion, Thallus Laminariae (Thallus Eckloniae) 10-15 weight portion, Concha Meretricis seu Cyclinae 10-15 weight portion, Radix Ranunculi Ternati 10-20 weight portion, Fructus Trichosanthis 10-20 weight portion, Armillariella mellea 10-20 weight portion, Semen Sesami Nigrum 5-10 weight portion, Folium Rhododendri Daurici 10-15 weight portion, Flos Lonicerae 10-15 weight portion, Ramulus Uncariae Cum Uncis 10-20 weight portion, Margarita 10-20 weight portion, Rhizoma Gastrodiae 10-15 weight portion, Pheretima 10-15 weight portion, Bombyx Batryticatus 15-25 weight portion, Rhizoma Acori Graminei 10-20 weight portion, Rhizoma Zingiberis Recens 15-20 weight portion, Folium hydrangeae strigosae rattan 10-20 weight portion, DAWANHUA 10-20 weight portion, Endothelium Corneum Gigeriae Galli 15-20 weight portion, Massa Medicata Fermentata 10-15 weight portion, Rhizoma Dioscoreae 15-20 weight portion, Cortex Magnoliae Officinalis 10-15 weight portion and Fructus Jujubae 15-20 weight portion.

In described medicine, the parts by weight of each raw medicinal material can also be preferably: Pericarpium Citri Reticulatae 21 weight portions, Uncaria tonkinensis Havil. 14 weight portions, Aeschna melanictera 15 weight portions, Cortex Juglandis mandshuricae 17 weight portions, Flos Rosae Rugosae 19 weight portions, FLOS MUME 12 weight portions, Semen Aesculi 15 weight portions, Calyx Kaki 18 weight portions, Semen Sinapis Albae 15 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Flos Inulae 12 weight portions, Succus Bambusae 18 weight portions, Concretio Silicea Bambusae 18 weight portions, Sargassum 17 weight portions, Thallus Laminariae (Thallus Eckloniae) 12 weight portions, Concha Meretricis seu Cyclinae 12 weight portions, Radix Ranunculi Ternati 15 weight portions, Fructus Trichosanthis 15 weight portions, Armillariella mellea 18 weight portions, Semen Sesami Nigrum 8 weight portions, Folium Rhododendri Daurici 13 weight portions, Flos Lonicerae 15 weight portions, Ramulus Uncariae Cum Uncis 15 weight portions, Margarita 16 weight portions, Rhizoma Gastrodiae 14 weight portions, Pheretima 12 weight portions, Bombyx Batryticatus 20 weight portions, Rhizoma Acori Graminei 15 weight portions, Rhizoma Zingiberis Recens 18 weight portions, Folium hydrangeae strigosae rattan 15 weight portions, DAWANHUA 15 weight portions, Endothelium Corneum Gigeriae Galli 17 weight portions, Massa Medicata Fermentata 12 weight portions, Rhizoma Dioscoreae 18 weight portions, Cortex Magnoliae Officinalis 14 weight portions and Fructus Jujubae 19 weight portions.

In order better to realize foregoing invention object, the present invention also provides a kind of preparation method that is used for the treatment of the medicine of wind-phlegm resistance closed form epilepsia vertiginosa disease, and when the dosage form of described medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each raw medicinal material of Chinese medicine described in other except Margarita and Semen Sesami Nigrum, adds the ethanol that the determining alcohol with respect to 2～4 times of mixture qualities is 85～95%, and reflux 1～3 hour, extracts, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 1～2 times of described medicinal residues quality is 85～95% again, and reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 300 order～400 object micropowders; The Margarita of described parts by weight and Semen Sesami Nigrum are placed on and in super micron mill, are ground into mixing fine powders;

The 3rd step, micropowders and mixing fine powders that second step is obtained, add microcrystalline Cellulose with respect to 0.1～0.3 times of its mixing quality, 0.05～0.15 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

When the dosage form of described medicine is granule, its preparation method comprises the following steps:

Step 1: raw medicinal material described in other except Margarita is mixed in described ratio, add the ethanol that the determining alcohol with respect to 4～8 times, mixture is 85%～95%, be heated to boiling reflux 3～5 hours, filter, adopt percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, the mastic that while being evaporated to 50～60 ℃ subsequently under vacuum 0.06～0.09Mpa, relative density is 1.04～1.10, spraying is dry, 160～175 ℃ of the inlet temperature of spray dryer, 80～85 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: the Margarita of described parts by weight is placed on and is ground into fine powder in super micron mill;

Step 3: by dried cream powder and fine powder mix homogeneously, in the mixture obtaining, add with respect to the cane sugar powder of 0.2～0.4 times of mixture quality and the dextrin of 0.1～0.2 times, granulation, in 40～50 ℃ dry, obtain granule.

The invention has the beneficial effects as follows: the traditional theory of Chinese medical science of drug utilization China of the present invention, take waking up the patient from unconsciousness by clearing away phlegm, endogenous wind stopping is relieving convulsion as main, that treatment wind-phlegm resistance closed form epilepsia vertiginosa disease has is rapid-action, determined curative effect, safe, the advantage that has no side effect and be difficult for recurring.

The specific embodiment

The invention provides a kind of medicine that is used for the treatment of wind-phlegm resistance closed form epilepsia vertiginosa disease, comprising following raw medicinal material: Pericarpium Citri Reticulatae, Uncaria tonkinensis Havil., Aeschna melanictera, Cortex Juglandis mandshuricae, Flos Rosae Rugosae, FLOS MUME, Semen Aesculi, Calyx Kaki, Semen Sinapis Albae, Radix Salviae Miltiorrhizae, Flos Inulae, Succus Bambusae, Concretio Silicea Bambusae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Concha Meretricis seu Cyclinae, Radix Ranunculi Ternati, Fructus Trichosanthis, Armillariella mellea, Semen Sesami Nigrum, Folium Rhododendri Daurici, Flos Lonicerae, Ramulus Uncariae Cum Uncis, Margarita, Rhizoma Gastrodiae, Pheretima, Bombyx Batryticatus, Rhizoma Acori Graminei, Rhizoma Zingiberis Recens, Folium hydrangeae strigosae rattan and DAWANHUA; Wherein, preferably, can also comprise: Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata, Rhizoma Dioscoreae, Cortex Magnoliae Officinalis and Fructus Jujubae.

Now the pharmacological properties of each taste Chinese medicine is described below:

Pericarpium Citri Reticulatae: nature and flavor are bitter, pungent, temperature.Return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm.Can be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Therefore Pericarpium Citri Reticulatae has three major types effect, the one, lead cold-evil in the heart, two broken stagnant gas, three strengthening the spleen stomaches.This three greatly on, Main Function is row QI of the spleen and stomach.The main transmitting and distributing the fluids of taste, therefore QI of the spleen and stomach capablely can dry, spleen invigorating, reduce phlegm, therefore can say again, Pericarpium Citri Reticulatae temperature can be supported spleen, pungent can being amusing, bitter can spleen invigorating.Due to the main row QI of the spleen and stomach of Pericarpium Citri Reticulatae, taste are located in middle Jiao, and middle Jiao's gas is current, and the gas of three warmers is also sprung up thereupon.Three warmers are the organ in charge of water circulation, and current water liquid, accompanies with wetting phase; Again for hiding mansion outside mansion, the upper and heart, lung, lower and liver, kidney.So the effect of Pericarpium Citri Reticulatae can wide and all Zang Fu, spread all over whole body wet.From lung, say, pungent loose lung qi, hardship is let out lung qi, and temperatureization cold can be controlled abundant expectoration cough with asthma, and gas is stopped up food and is stopped; From the heart, say, pungent happy gas, hardship is let out heart-fire, and warm removing dampness is turbid, can control irritable feverish sensation in the chest, and the implication sound of vomiting is smelly; From liver, say, pungent loose stagnation of liver-QI, liver-fire falls in hardship, warming for eliminaring cold-damp, so its can treating the liver strongly fragrantly has heat, drink is stopped eating stagnant; From kidney, say, pungent profit kidney is dry, and it is wet that hardship is let out kidney, and gentle kidney qi, so it can control life fire deficiency, indigestion.Certainly, all explanations, all with wet relevant with spleen, so its property of medicine effect performance leeway is larger, all can be used in general activating QI to eliminate phlegm side.Anesthetized rabbit, cat, dog intravenous injection are had to hypotensive effect slowly, and its decompression principle is owing to directly acting on vascular smooth muscle.

Uncaria tonkinensis Havil.: puckery, sweet, be slightly cold.Function cures mainly: heat clearing away suppressing the hyperactive liver, endogenous wind stopping spasmolytic, promoting blood circulation to restore menstrual flow.Cure mainly rheumatic arthritis, traumatic injury, sciatica, fracture, infantile convulsion, hypertension, migraine, pediatric proctoptosis.Also can control the diseases such as leukorrhagia, traumatic hemorrhage.

Aeschna melanictera: salty in the mouth; Warm in nature.Return kidney channel.Function cures mainly: kidney-reinforcing Yang-strengthening; The secret essence of reinforcing YIN-essence.The main impotence of suffering from a deficiency of the kidney; Seminal emission; Breath with cough.

Cortex Juglandis mandshuricae: hardship; Pungent; Cold nature.Function cures mainly: heat clearing and damp drying; Eliminating pathogen in the liver improving eyesight.Main damp-heat diarrhea; Normal lower yellow thick; Conjunctival congestion and swelling pain; Hordeolum; Epiphora induced by wind; Bone tuberculosis.

Flos Rosae Rugosae: warm in nature, sweet and slightly bitter taste, returns liver spleen channel.< < A Supplement to the Compendium of Materia Medica > >: " and blood, promoting the circulation of blood, regulates the flow of vital energy.Control migratory arthralgia." < < book on Chinese herbal medicine new > > again: " the strongly fragrant gas of soothing liver-QI gallbladder, spleen invigorating pathogenic fire reducing.Control cold type of pain in abdomen, gastral cavilty is long-pending cold, and holding concurrently can removing blood stasis." promoting the circulation of QI, promoting the circulation of blood, control migratory arthralgia, loose tired pain relieving.Flos Rosae Rugosae and Herb have convergence, can be used for woman in menstrual period too much, and leucorrhea with red and white discharge and enteritis, dysentery, the red half of intestinal are hemorrhage etc.Regulate the flow of vital energy resolving depression and blood dissipating blood stasis.Cure mainly stomachache due to hyperactive liver-QI attacking the stomach, new lingering pathogenic wind numbness, the spitting of blood of spitting blood, menoxenia, leucorrhea with red and white discharge, dysentery, acute mastitis, toxic swelling.In Flos Rosae Rugosae, contain 300 various chemical components, as fragrant alcohol, aldehyde, fatty acid, phenol with containing oil and the fat of essence, often eat in Flos Rosae Rugosae goods with the easing the affected liver stomach of waking up, have a respite and invigorate blood circulation, looks improving and the skin nourishing, makes us refreshing refreshing.

FLOS MUME: sour and astringent, flat.Return liver, stomach, lung meridian.< < A Supplement to the Compendium of Materia Medica > >: " < < all sorts of flowers mirror > >: powder for improving appetite is evil; the food of cooking congee; help the gas of sun clearly to rise; distillation point tea; promoting the production of body fluid to quench thirst, expelling summer-heat is washed tired." soothing liver-QI, stomach function regulating, reduces phlegm.Control globus hystericus, stomachache due to hyperactive liver-QI attacking the stomach, inappetence, dizziness, scrofula.Stomachache due to hyperactive liver-QI attacking the stomach.The circulation of qi promoting of this product fragrance enters liver stomach, and energy dispersing the stagnated live-QI to relieve the stagnation of QI, is amusing, regulating the flow of Qi and the middle Jiao.The distending pain over the hypochondrium for the treatment of stagnation of liver-QI and stomach-QI, gastral cavity abdomen feeling of fullness, belch is indigestion and loss of appetite etc., can with the compatibility such as Radix Bupleuri, Fructus Citri Sarcodactylis, Rhizoma Cyperi.Globus hystericus.

Semen Aesculi: warm in nature, sweet in the mouth; Return liver, stomach warp.The < < detailed outline > > that picks up any lost article from the road: " the inherited from one's ancestors side of Pueraria lobota, controls heart cold syndrome of the stomach pain, worm pain.The alleviating distention in middle-JIAO therapeutic method to keep the adverse QI flowing downwards, controls gastral cavilty liver diaphragm and expands, infantile malnutrition malaria dysentery, haematemesis impairment caused by overstrain, flat stomach dredging collateral." regulating the flow of QI to ease the stomach, and stomach and alleviating pain., gastralgia vexed for breast abdominal distention.Semen Aesculi saponin treatment aged bronchial asthma, can improve quickly and effectively clinical symptoms, increase to breathe flow velocity peak value, Horse chest Nut P.E Semen Aesculi saponin 16 ~ 18mg adds in 10% Glucose Liquid after quiet treatment cerebral trauma, benign Intracranial Hypertension, brain operation, and effective percentage reaches 91%.Can be used for treating angina pectoris, hyperlipemia, this product is can dispersing the stagnated live-QI to relieve the stagnation of QI stagnant with row, again can regulating the flow of QI to ease the stomach with stomach function regulating.The cards such as the hypochondriac pain uncomfortable in chest for the treatment of stagnation of liver-QI and stomach-QI, abdominal distention.

Calyx Kaki: puckery, property is flat, enters lung, spleen, stomach, large intestine channel.There are clearing heat and moistening lung, promoting the production of body fluid to quench thirst, the effect of invigorating the spleen for dissipating phlegm; Be used for the treatment of cough due to lung-heat, xerostomia is thirsty, vomiting, diarrhea.< < Compendium of Materia Medica > >: " cough with dyspnea person, on gas chong channel under umbilicus is straight to swallowing diaphragm, oh make a mistake, not smoothgoing contrary sound also." 0.5% Calyx kaki extract (ST) 50mg/kg lumbar injection is in mice, can show to resist the chamber that chloroform brings out and quiver; Also can resist rat ventricular due to aconitine, barium chloride, mouse peritoneal injection, obviously reduces spontaneous activity, strengthens the syngignoscism of sub-threshold dose pentobarbital sodium, extends its length of one's sleep, and the mice straub tail reaction that obviously antagonism morphine causes.

Semen Sinapis Albae: acrid in the mouth, temperature, nontoxic.Enter the warp of liver, spleen, lung, stomach, the heart and collaterals of the uterus.< < Japan hanako materia medica > >: " control the swollen and paralysis of pathogenic wind toxic, vinegar grind Fu it.Flutter damage blood stasis, lumbago kidney cold-peace Rhizoma Zingiberis Recens grinds, micro-warm, is coated with and pastes.Pained, wine vinegar takes it." < < Compendium of Materia Medica > >: " Semen Sinapis Albae is pungent can enter lung, and temperature can be dispersed, therefore have promoting the circulation of QI eliminating phlegm, warming middle-JIAO appetizing, loose pain to subside a swelling, ward off the merit of evil." can remove cold air, settling five organs, by the expectorant of film diaphragm, wards off stealthy gas, the addiction that disappears malaria, the Dingchuan that drops interests, sharp key improving eyesight, removing blood stasis relieves the pain, and all can prove effective.Can energy dissipating fall, energy complementary energy liter, helps all tonics, the outstanding kind merit of receiving.Mustard flour, as flavoring agent, increases salivation and amylase activity, and heart size and heart rate are reduced.Can stimulate in a small amount gastric mucosa to increase the secretion of gastric juice and pancreatic juice, sometimes can alleviate intractable singultus.

Radix Salviae Miltiorrhizae: hardship, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.< < detailed outline > > carries: Radix Salviae Miltiorrhizae, press the sensible opinion of < < married woman > > cloud, SIWU TANG is controlled gynecopathy, pay no attention to antenatal puerperal, how many through water, all can be general, only taste Radix Salviae Miltiorrhizae is loose, cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls, stops metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote liver blood circulation, is beneficial to liver cell regeneration.

Flos Inulae: salty, warm; Enter lung, liver, stomach warp.Function expectorant, the therapeutic method to keep the adverse QI flowing downwards, softening the hard mass, row water.< < herbal classic > >: " main stagnation of QI, fullness in the hypochondrium, palpitation with fear.Dewater, remove cold and heat between the five internal organs, invigorating middle warmer, the therapeutic method to keep the adverse QI flowing downwards." < < property of medicine opinion > >: " main rib side of body gas, lower cold and heat edema, cures mainly bladder retained water, removes by large abdomen appetizing, the contrary not lower food of preventing or arresting vomiting." cure mainly in the heart expectorant knot, the lower distension of the side of body, cough with asthma, singultus, saliva is as shellac varnish, epigastric oppression Ying, eructation unrelieved, extensive abdominal edema.

Succus Bambusae: sweetness and bitterness, cold; Enter the heart, stomach warp.< < Bencao Beiyao > >: " pathogenic wind expelling pathogenic fire reducing, moisturizes row expectorant, the tonifying YIN that nourishes blood, sharp key tomorrow.Control apoplexy locked mouth, the large heat of expectorant fan, puerperal tetanus is demented, and unhappiness is quenched one's thirst, spontaneous sweating due to deficientcy of blood.Liver-fire, falls in " < < book on Chinese herbal medicine is new > > again: " clearing away heart-fire, reduces phlegm and quenches the thirst, and antipyretic relieving restlessness, controls toothache, bright eyes." fire of the lung stomach that clears away heart-fire has that eliminating phlegm is moisturized, the effect of arresting convulsion.Be mainly used in controlling middle wind-phlegm fan, lung-heat expectorant is stopped up, infantile convulsion, epilepsy, high fever excessive thirst, restlessness during pregnancy, tetanus.Succus Bambusae sweet in the mouth is slow, can be except the large hot person that has of the deficiency of YIN, Great Cold, person sayed its merit also, non-with gas speech, good fortune with could, if say not so, people eats Radix Crotalariae szemoensis since the childhood to the old, can no one because of Radix Crotalariae szemoensis cold and ill, drop be Radix Crotalariae szemoensis liquid also, how condition vacation, in the fire person of forming, trembles with fear so very.

Concretio Silicea Bambusae: sweet, cold; Enter the heart, liver, lung meridian.< < Japan hanako materia medica > >: " control middle wind-phlegm and stop up, acute aphasia in silence, convulsive seizure induced by terror in children and epilepsy expectorant." < < Kaibao Bencao > >: " main infantile convulsion sky hangs, and relieving palpitation improving eyesight, goes all wind heat, treats incised wound hemostasis, nourishes the five internal organs." function clear heat and eliminate phlegm, cool heart arresting convulsion.Cure mainly calentura coma delirium, middle wind-phlegm fan in silence, twitch, epilepsy by infantile convulsion.Phlegm-heat cough.Fungus Zhuhuang water decoction extract 2-3.1g/kg subcutaneous injection, has good analgesic activity to mice acetic acid zest pain.Fungus Zhuhuang polysaccharide SB1 and SB2, through pharmacology preliminary test, have certain curative effect to hepatitis, can show prolongation blood plasma recalcification time, and in blood coagulation tests, this medicine can extend clotting time, may extend relevant with recalcification time.

Sargassum: bitter in the mouth, salty, cold in nature, nontoxic; Enter lung, spleen, kidney, stomach warp.< < herbal classic > >: " main goiter gas, core under neck, broken eliminating stagnation gas, the hard gas of carbuncle lump in the abdomen, ring up and down in abdomen, lower 12 edema." < < property of medicine opinion > >: " control dry phlegm-syndrome knot full, treat hernia tenesmus, pain core is swollen, removes active borhorygmus, faint uttering a word." containing a large amount of iodine that can obviously reduce Blood Cholesterol content in Sargassum, normal food is conducive to maintain the function of cardiovascular system, makes blood vessel high resilience, thereby ensures the regular supply of skin-nourishing.Methionine in Sargassum, cystine are enriched, and can prevent xerosis cutis, and normal food also can make dry skin be rich in gloss, and oily skin can be improved fat secretion.Contained vitamin is abundant, can safeguard epithelial tissue healthy growth, reduces pigment spot.In Sargassum, contained iodine can be used to correct the subthyroidism causing because of ferrum iodine.

Thallus Laminariae (Thallus Eckloniae): salty; Cold; Nontoxic.Return liver, stomach, kidney channel.The beautiful Chinese catalpa medicine of < < solution > >: " sluicing is dried, removing mass softening the hard mass.Clearing away heat and promoting diuresis, controls flatulence watery distension, scrofula goiter, and insane hernia malignant boil, with Sargassum, the same merit of Thallus Laminariae (Thallus Eckloniae)." eliminating phlegm and softening indurated mass; Diuretic detumescent.Main scrofula; Goiter; Dysphagic; (Epileptic is ruined) hernia beriberi edema.For goiter, scrofula, painful and swollen testis, phlegm retention edema.It is not enough that Thallus Laminariae (Thallus Eckloniae) can be used to correct the thyroid function being caused by iodine deficiency, also can temporarily suppress hyperthyroid metabolism rate and mitigation symptoms simultaneously, but can not be lasting, the preparation before can operating.

Concha Meretricis seu Cyclinae: salty, flat, bitter in the mouth; Enter the heart, kidney channel.< < Japan hanako materia medica > >: " stopping vomiting is contrary, impotence, breast is coerced swollen urgency, lumbago, five hemorrhoid, married woman's metrorrhagia, leukorrheal diseases." < < property of medicine opinion > >: " air supporting of harnessing the river is swollen, and lower urine, controls the contrary upper gas of coughing, a lower tumor wart." heat clearing away, diuretic reduce phlegm, softening the hard mass.Control heat-phlegm and breathe heavily and cough, edema, gonorrhea, wart, tumor, gather, blood agglomeration chest pain, dysentery, hemorrhoid, metrorrhagia, leukorrhagia.The heat clearing away of the cold energy of this product, salty can softening the hard mass, therefore can clearing away lung-heat, change thick expectorant, the wart that disappears eliminating stagnation, the expectorant dyspnea of heat type causing for lung-heat is coughed, feeling of stuffiness in chest hypochondriac pain and by the caused goiter of sucutaneous nodule, scrofula etc., and have inducing diuresis to remove edema, relieving gastric hyperacidity to alleviate stomachache effect, can be used for again the cards such as ascites, edema, stomachache acid regurgitation.

Radix Ranunculi Ternati: sweet, pungent, tepor.Return liver, lung meridian.Dissipating phlegm and resolving masses, removing toxic substances and promoting subsidence of swelling.Cure mainly scrofula sucutaneous nodule, furuncle, worm venom, migraine, malaria, toothache.Pulmonary tuberculosis, tuberculous lymphadenitis, lymphadenitis, pharyngolaryngitis.For the mechanism of Radix Ranunculi Ternati anti-tubercle bacillus, Zhan Li etc. adopt reverse transcriptional PCR sxemiquantitative (QC-RT-PCR) method and PCR method, the little Herba Ranunculi Japonici lactone of Radix Ranunculi Ternati effective ingredient (Tern) have been carried out to the research of anti-tubercle bacillus molecular immunology mechanism.Result show Tern may inducing peripheral blood vessel GLS high level gene expression, kill pathogenic bacterium MBT in born of the same parents, and be dose dependent, to drug resistance, induce level difference without significance with untreated lunger.The employing life or death cell countings such as Zhang Jiahua and 3H-Tdr mix method, and compare with homoharringtonine, have shown that eryside all has certain lethal effect to various leukaemias.

Fructus Trichosanthis: nature and flavor sweetness and bitterness, cold.Enter lung, stomach, large intestine channel.< < Compendium of Materia Medica > > says: " lung moistening is dry, pathogenic fire reducing.Control cough, clearing away phlegm knot, throat, subduing inflammation sore." < < book on Chinese herbal medicine just reads > > and records: " and Fructus Trichosanthis, nature and flavor are identical with pollen, only moisten the merits and demerits of falling it.Therefore all stagnation of heat in upper-JIAOs, the cards such as dirty greasy phlegm-fire cough, all available it.The fiery person of genus of all lung abscess, acute appendicitis, acute mastitis, particularly suitable." function cures mainly: lung moistening, reduce phlegm, eliminating stagnation, intestine moistening.Control phlegm-heat cough, the thoracic obstruction, blocked-up chest, consumptive lung disease hemoptysis, quenches one's thirst, jaundice, constipation, carbuncle from the beginning of.

Armillariella mellea: sweet, temperature.Function cures mainly: dispelling, collateral-activating, bone and muscle strengthening.For lumbago and skelalgia, rickets, epilepsy.

Semen Sesami Nigrum: sweet, flat.Return liver, kidney, large intestine channel.Function cures mainly: invigorating the liver and kidney, and benefiting essence-blood, intestine moistening is dry.For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.

Folium Rhododendri Daurici: pungent, bitter, cold in nature, mild toxicity; Enter lung meridian.Clinical observation proves that treatment chronic tracheitis simple type is had to good therapeutic effect, and to panting, type and merging emphysema person effect are poor.Cough suppressing effect is showing, and eliminates the phlegm and takes second place, and relievings asthma poor, and antiinflammation is not strong, can not preventing cold.The contained Eucaulen of this product, (Guaiazulene) have antiinflammatory and the effect of excited uterus, and useful as anti-inflammatory agents, though avacularin has hypotensive effect to anesthetized dog, but the persistent period is very short, and easily produce tachyphylaxis, andromedotoxin have certain analgesic activity, minimum analgesia index is 8.60.Scopolamine can be strengthened its analgesic activity greatly, and toxicity is had no significant effect, and on the affecting farrerol and can suppress in vitro rat trachea-lung tissue and breathe of Tissue respiration, makes oxygen consumption reduce approximately 26.4%, and Main Function is in the enzyme system of pyridine nucleotide.

Flos Lonicerae: the loose poison of heat clearing away, < < Compendium of Materia Medica > > carries " Flos Lonicerae, is good at removing toxic substances, therefore control carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating for the treatment of epidemic febrile disease, toxic-heat and blood stasis, the diseases such as carbuncle and ulcer.Modern pharmacological research shows, that Flos Lonicerae has is antibacterial, antiviral, antiinflammatory, antipyretic, regulate the effect traditional Chinese medical science such as immunity to think, Flos Lonicerae is cold in nature, sweet in the mouth, gas are put down, and has the effect of heat-clearing and toxic substances removing, can treat the diseases such as pyretic toxicity abscess, carbuncle furuncle.And have the loose effect of a surname concurrently.Flos Lonicerae antipyretic and antidote functions is quite strong.

Ramulus Uncariae Cum Uncis: sweet, hardship, is slightly cold; Enter Liver Channel, heart channel.< < detailed outline > >: " the large number of people revolves dizzy, suppressing liver-wind, and except heat in the heart, children's's infantile tic stomachache, sends out macule." < < Tang materia medica > >: " Ramulus Uncariae Cum Uncis goes out Liang Zhou.Leaf is elongated, and spinosity between stem, if shape fishhook person." function heat clearing away suppressing the hyperactive liver, relieving spasm by subduing liver-wind.Cure mainly infantile convulsion, night cry, intenseness of heat wind symptom, eclamposia, dizziness due to hyperactivity of liver-YANG, liver-fire distending pain in the head.Ramulus Uncariae Cum Uncis decoct, Rhomotoxine mitrinermine, no matter to anesthetized animal or anesthetized animal not, intact animal or hypertension animal, no matter also intravenous injection or gastric infusion all have hypotensive effect.Ramulus Uncariae cum Uncis alkali shows the hemodynamic Effects of Conscious Rat: LVSP, Vmax, dp/dtmax significantly declines immediately, its fall is respectively one 7.8%, 1 15.9% and 1 23.2%, do not maintain 5,10,20 minutes not etc., then return to gradually level before medicine, and be significantly higher than before administration LVSP to 90 minute time.

Margarita: salty, cold.Return liver, heart channel.< < Chinese medicine voluminous dictionary > >: " liver nourishing is cloudy, clearing away liver-fire.Control demented infantile convulsion, dizziness, tinnitus, heart beating, pleuroperitoneum is swollen, women's heat in blood, metrorrhagia, frightened the jerking of children's sent out convulsion." suppressing the hyperactive liver, YANG hyperactivity suppressing, arresting convulsion, hemostasis.Control dizziness, tinnitus, cardiopalmus, insomnia, demented, infantile convulsion, spits blood, epistaxis, metrorrhagia.The nacreous layer injection such as Pteria martensii Dunker and scrimp hat freshwater mussel have protective effect to carbon tetrachloride liver damage, can make hepatocellular damage alleviate, and the recovery of glutamate pyruvate transaminase is accelerated.Hydrochloric acid or sulphuric acid hydrolysis product all can suppress the contraction of the guinea pig in vitro intestinal tube that histamine causes.With Margarita powder, to mouse stomach, can obviously reduce its autonomic activities, and the maincenter of pentobarbital sodium is suppressed to have obvious synergism; The sulfate hydrolyzate of Concha Margaritifera, can increase the heart beating amplitude of isolated heart.

Rhizoma Gastrodiae: sweet flat, return Liver Channel.< < herbal classic is met former > >: " though Rhizoma Gastrodiae is not dry, wind agent after all, if blood deficiency is calm, the scorching headache of fire, xerostomia are not just closed person, can not abuse." embellish but not dry, master enters Liver Channel, is longer than suppressing the hyperactive liver to relieve the wind syndrome, and the disease of all liver-wind stirring up internallys, the vertigo, no matter deficiency and excess is key medicine.The main component of Rhizoma Gastrodiae is gastrodin, heat highly volatile.Rhizoma Gastrodiae and his medicine are decocted altogether and can be lost because of heat the effective ingredient of sedation and analgesia.Rhizoma Gastrodiae has calmness, analgesia, anticonvulsant action; Can increase cerebral blood flow, reduce cerebral vascular resistance, slightly shrink cerebrovascular, increase coronary vasodilator flow; Can reduce blood pressure, decreased heart rate, has protective effect to myocardial ischemia; Gastrodia elata polysaccharide has immunocompetence.While using single Rhizoma Gastrodiae or gastrodia tuber preparation, as while there is dizziness, tachypnea uncomfortable in chest, nausea and vomiting, heart beating and accelerated breathing, skin pruritus etc., drug withdrawal immediately, serious symptom person should arrive hospital therapy in time.

Pheretima: heat clearing away, spasmolytic, diuresis, removing toxic substances.For calentura mania and irritation, infantile convulsion, cough with asthma, headache conjunctival congestion, laryngopharynx swelling and pain, urinary obstruction, Fengshi Guanjie pain, the diseases such as hemiplegia Pheretima dish.External is coated with the diseases such as erysipelas, dermatitis rhus.Lumbar injection earthworm injection 10g/kg, surveys the pre-always cerebral infarction that artery ligation causes to mongolian gerbils one and has certain preventive effect in advance, can alleviate the symptom of cerebral infarction; Mice only gavages Pheretima extract l1mg/ every day, and continuous 58d, to the sarcoma S180 transplanting.Have obvious inhibitory action, not only tumor body obviously reduces, and can extend the life cycle of mice.Routine dose toxicity is little, and headache, giddy can appear in excessive use, and blood pressure is fallen after rising, stomachache, dyspnea, digestive tract hemorrhage.Yang-energy is deficient, weakness of the spleen and stomach, the dyspnea with rapid and short breath of suffering from a deficiency of the kidney, blood deficiency can not moisten nourishing muscle and tendon arteries and veins person and should not use.

Bombyx Batryticatus: salty, pungent, flat; Return liver, lung, stomach warp.< < Sheng Nong's herbal classic > >: " main pediatric epilepsy scared, night cry, go three worms, goes out black, makes us complexion good, and the cloudy infections of man is sick." < < Compendium of Materia Medica > >: " erysipelas is had an itch for loose wind-phlegm tuberculosis, scrofula, wind syndrome of head, wind worm toothache, skin wind skin ulcer ... all incised wounds, the furuncle wind hemorrhoid that swell." Bombyx Batryticatus alcohol water-leach liquor all has hypnosis, anticonvulsant action to mice, rabbit; Its extracting solution in vivo, all have a stronger anticoagulation outward; Bombyx Batryticatus powder has good hypoglycemic activity; In vitro tests, has slight bacteriostasis to staphylococcus aureus, bacillus pyocyaneus, and the external breathing that suppresses human hepatoma cell of its alcohol extract, can be used for the treatment of rectum tumor type polyp.

Rhizoma Acori Graminei: nature and flavor are pungent, bitter, temperature.GUIXIN, stomach warp.Can removing dampness whet the appetite, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae., keep silent a mouthful dysentery not hungry for gastral cavity painful abdominal mass, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.< < does not record > > and records it: " warming intestines and stomach, stops normal urination for main deafness, carbuncle skin ulcer, and extremity arthralgia chiefly caused by damp pathogen, must not bend and stretch, children's's pyrexial malaria, body accumulated heat is not understood, and can bathe soup.Audition improvement order, beneficial intelligence." Rhizoma Acori Graminei decoct for oral administration can facilitating digestion liquid secretion and prevent gastrointestinal abnormal fermentation, and have the effect of alleviating intestinal tube smooth muscle spasm. the asaricin containing in Rhizoma Acori Graminei can resist the excitation of the intestine in vitro that barium chloride causes.

Rhizoma Zingiberis Recens: acrid in the mouth, slightly warm in nature, returns lung, spleen, stomach warp, has relieving the exterior syndrome by diaphoresis, warming middle-JIAO to arrest vomiting, the effect of warming the lung to relieve cough, for Deficiency and coldness of spleen and stomach, loss of appetite, nausea and vomiting, or vomiting due to fluid-retention, the vomiting of disorder of stomach-QI; Wind and cold or cold-phlegm cough; Cold, fever with aversion to wind, nasal obstruction headache waits card.Its distinctive " gingerol " can stimulating gastrointestinal mucosa, make gastrointestinal tract congested, digestion power strengthens, and can effectively treat the abdominal distention of eating cold and cool food and too much causing, stomachache, diarrhoea, vomiting etc.Ate after Rhizoma Zingiberis Recens, people has the sensation of health heating, and this is because it can distend the blood vessels, and blood circulation is accelerated, and impels pore with it to open, and so not only the unnecessary torrid zone can be walked, and also the pathogenic bacteria in body, cold is together taken out of simultaneously.When health, eaten cold and cool thing, be subject to drench with rain or in air-conditioned room, stayed long afterwards, eaten Rhizoma Zingiberis Recens and just can eliminate in time because of the cold various discomforts that remake of human body.For the pungent stomachic of armaticity, there are the effects such as warm, excited, diaphoresis, preventing or arresting vomiting, removing toxic substances, warming the lung to relieve cough, for fish Eriocheir sinensis poison, the drug intoxication such as the Rhizoma Pinelliae, Rhizoma Arisaematis have Detoxication especially.Be applicable to affection of exogenous wind-cold, headache, phlegm retention, cough, gastrofrigid vomiting; After suffering ice and snow, wet, the cold invasion and attack of water, suddenly with ginger decoction, drink it, can promote blood, disperse cold-evil.

Folium hydrangeae strigosae rattan: sweet; Light; Cool.Function cures mainly: heat-clearing and toxic substances removing; Inducing diuresis and reducing edema.Main cold, fever; Laryngopharynx swelling and pain; Icterohepatitis; Conjunctival congestion and swelling pain; Carbuncle furuncle.

DAWANHUA: sweet, light, flat.Function cures mainly: root stock: invigorating the spleen and benefiting QI, diuresis, regulating menstruation, leukorrhagia stopping; For insufficiency of the spleen dyspepsia, menoxenia, leucorrhea, milk is rare.Flower: pain relieving; Toothache is controlled in external.

Endothelium Corneum Gigeriae Galli: sweet, cold, return spleen, stomach, small intestinal, urinary bladder channel, for promoting digestion and invigorating the stomach, arresting seminal emission.Endothelium Corneum Gigeriae Galli is containing gastric hormone, keratin, aminoacid and micro-pepsin, amylase etc.After oral Endothelium Corneum Gigeriae Galli powder, the secretory volume of gastric juice, acidity and eupepsy all increase, and stomach motion is strengthened, emptying quickening.Its acid extraction liquid or decoct can accelerate to get rid of radiostrontium from urine.

Massa Medicata Fermentata: sweet in the mouth, pungent, warm in nature, enter spleen, stomach warp, has digestion-promoting spleen-invigorating, reduces phlegm, the effect such as blood-activating analgetic.Be mainly used in dyspepsia and do not change, distension and fullness in the abdomen, the symptoms such as lack of appetite diarrhoea, spleen fortune is lost to the phlegm syndrome due to being good for, and blood stasis pain have certain curative effect.

Rhizoma Dioscoreae: sweet in the mouth, property are put down, and enter lung, spleen, kidney channel; Not dry oiliness, there are strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, grow that will is calmed the nerves, the effect of life lengthening; Cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red disease such as swollen, fat of the frequent micturition of quenching one's thirst, seminal emission premature ejaculation, leukorrhagia nebulousurine, skin.< < Compendium of Materia Medica > > summarizes five large functions " kidney tonifying gas, strengthening the spleen and stomach, stopping leak dysentery, the saliva that reduces phlegm, profit skin ".Rhizoma Dioscoreae is cooked congee or simmers after ripe and take with crystal sugar, and, colitis poor to health, deficiency of the kidney chronic diseases are all effective in cure.Strengthen the spleen and stomach: treatment weakness of the spleen and stomach, have loose bowels, body is tired, lack of appetite, sweating due to debility.Lung benefiting nourishing kidney: this product is cold not dry, sweet in the mouth matter profit, can treat lung suffer from a deficiency of the kidney damage quench one's thirst, pass out semen, be with inferior disease.Be described as angle's medicine.

Cortex Magnoliae Officinalis: Cortex Magnoliae Officinalis and volatile oil bitter in the mouth thereof can stimulate the sense of taste, reflexively causes the quickening of saliva, gastric secretion, gastrointestinal peristalsis, and has stomach invigorating digestion-aid effect; Resisting pathogenic microbes acting body experiment showed, that Cortex Magnoliae Officinalis decoct all has antibacterial action to gram negative bacillis such as the gram positive bacterias such as staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, bordetella pertussis and anthrax bacillus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus subtilis outward; Decoct has inhibitory action to Bufo siccus isolated heart. magnocurarine drug administration by injection, when lower than muscle relaxant amount, there is obvious hypotensive effect, this effect can not be by antihistaminic institute antagonism, the blood pressure lowering of Bolos intravenous administration is held time and is about 10～15 minutes, the blood pressure lowering of intramuscular administration is held time and can be reached more than 1 hour. and the tincture hydrotrope of Flos Magnoliae Officinalis all has hypotensive effect to anesthetized cat, the quiet note of rabbit or intramuscular injection, and can make heart rate accelerate.

Fructus Jujubae: the nutritional labeling Chinese medicine theories such as rich in proteins, fat, saccharide, carotene, vitamin B group, vitamin C, Citrin and calcium, phosphorus, ferrum and cyclic adenosine monophosphate are thought, Fructus Jujubae has the effects such as tonify deficiency QI invigorating, nourishing blood to tranquillize the mind, invigorating the spleen and regulating the stomach, is the good health nutrient fruit of the patients such as weakness of the spleen and stomach, insufficiency of vital energy and blood, lassitude, insomnia and dreamful sleep.Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Energy circulation of qi promoting, invigorates blood circulation, regulating menstruation.For menoxenia, red collapsing, leucorrhea, is the good merchantable brand of enriching blood.

When the dosage form of described medicine is tablet, its preparation method comprises the following steps:

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 tablet

The embodiment of the present invention provides a kind of medicine that is used for the treatment of wind-phlegm resistance closed form epilepsia vertiginosa disease, raw medicinal material by following parts by weight is made: Pericarpium Citri Reticulatae 18 weight portions, Uncaria tonkinensis Havil. 15 weight portions, Aeschna melanictera 15 weight portions, Cortex Juglandis mandshuricae 15 weight portions, Flos Rosae Rugosae 19 weight portions, FLOS MUME 12 weight portions, Semen Aesculi 15 weight portions, Calyx Kaki 17 weight portions, Semen Sinapis Albae 15 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Flos Inulae 12 weight portions, Succus Bambusae 17 weight portions, Concretio Silicea Bambusae 18 weight portions, Sargassum 18 weight portions, Thallus Laminariae (Thallus Eckloniae) 12 weight portions, Concha Meretricis seu Cyclinae 12 weight portions, Radix Ranunculi Ternati 15 weight portions, Fructus Trichosanthis 15 weight portions, Armillariella mellea 15 weight portions, Semen Sesami Nigrum 12 weight portions, Folium Rhododendri Daurici 12 weight portions, Flos Lonicerae 14 weight portions, Ramulus Uncariae Cum Uncis 15 weight portions, Margarita 15 weight portions, Rhizoma Gastrodiae 12 weight portions, Pheretima 12 weight portions, Bombyx Batryticatus 21 weight portions, Rhizoma Acori Graminei 15 weight portions, Rhizoma Zingiberis Recens 19 weight portions, Folium hydrangeae strigosae rattan 15 weight portions and DAWANHUA 15 weight portions.

Its preparation method comprises the following steps:

The first step, is mixed in proportion each raw medicinal material of Chinese medicine described in other except Margarita and Semen Sesami Nigrum, adds the ethanol that the determining alcohol with respect to 3 times of mixture qualities is 90%, and reflux 2 hours, extracts, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 1.5 times of described medicinal residues quality is 90% again, and reflux 2 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1.5 hours, pulverizes, and sieves, and obtains 350 object micropowders; The Margarita of described parts by weight and Semen Sesami Nigrum are placed on and in super micron mill, are ground into mixing fine powders;

The 3rd step, micropowders and mixing fine powders that second step is obtained, add microcrystalline Cellulose with respect to 0.2 times of its mixing quality, 0.1 times of lactose, the starch of 0.2 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.025 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

Embodiment 2 granules

The embodiment of the present invention provides a kind of medicine that is used for the treatment of wind-phlegm resistance closed form epilepsia vertiginosa disease, is made: Pericarpium Citri Reticulatae 21 weight portions by the raw medicinal material of following parts by weight, Uncaria tonkinensis Havil. 14 weight portions, Aeschna melanictera 15 weight portions, Cortex Juglandis mandshuricae 17 weight portions, Flos Rosae Rugosae 19 weight portions, FLOS MUME 12 weight portions, Semen Aesculi 15 weight portions, Calyx Kaki 18 weight portions, Semen Sinapis Albae 15 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Flos Inulae 12 weight portions, Succus Bambusae 18 weight portions, Concretio Silicea Bambusae 18 weight portions, Sargassum 17 weight portions, Thallus Laminariae (Thallus Eckloniae) 12 weight portions, Concha Meretricis seu Cyclinae 12 weight portions, Radix Ranunculi Ternati 15 weight portions, Fructus Trichosanthis 15 weight portions, Armillariella mellea 18 weight portions, Semen Sesami Nigrum 8 weight portions, Folium Rhododendri Daurici 13 weight portions, Flos Lonicerae 15 weight portions, Ramulus Uncariae Cum Uncis 15 weight portions, Margarita 16 weight portions, Rhizoma Gastrodiae 14 weight portions, Pheretima 12 weight portions, Bombyx Batryticatus 20 weight portions, Rhizoma Acori Graminei 15 weight portions, Rhizoma Zingiberis Recens 18 weight portions, Folium hydrangeae strigosae rattan 15 weight portions, DAWANHUA 15 weight portions, Endothelium Corneum Gigeriae Galli 17 weight portions, Massa Medicata Fermentata 12 weight portions, Rhizoma Dioscoreae 18 weight portions, Cortex Magnoliae Officinalis 14 weight portions and Fructus Jujubae 19 weight portions.

Its preparation method comprises the following steps:

Step 1: described raw medicinal material is mixed in described ratio, add the ethanol that the determining alcohol with respect to 6 times, mixture is 90%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 1.5ml per minute percolation slowly, collect percolate, the mastic that while being evaporated to 55 ℃ subsequently under vacuum 0.07Mpa, relative density is 1.08, spraying is dry, 170 ℃ of the inlet temperature of spray dryer, 82 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 3: by dried cream powder and fine powder mix homogeneously, in the mixture obtaining, add with respect to the cane sugar powder of 0.3 times of mixture quality and the dextrin of 0.2 times, granulation, in 45 ℃ dry, obtain granule.

Toxicity test

Acute toxicity test: 60 of application NIH mices, SPF level, male and female half and half, body weight 17～24g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, matched group and administration group, test front fasting 12 hours; The granule of embodiments of the invention 2 preparations is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 28.7 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage granule LD50>28.7 of the present invention crude drug/kg, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 4.6g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight take 21g) oral administration gavage Chinese medicine of the present invention is quantity 745 times.Therefore the acute toxicity of medicine of the present invention is low, clinical drug safety.

Long term toxicity test: by the granule of the embodiment of the present invention 2 to mice by 6.43,15.72 and 16 weeks (1.0ml/100g body weight of 36.41g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: Chinese medicine preparation of the present invention all has no significant effect indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

Clinical trial

Case selection: fetch the patient that 120 examples that come from the court's patients in neurological department suffer from wind-phlegm resistance closed form epilepsia vertiginosa disease, male 66 examples, female's 54 examples; Age 19-58 year, medical history 6 months-5 years; Patient is by following symptom: the dizzy companion of repeated relapsing looks thing rotation, start-stop is unexpected, the degree of each outbreak symptom is different, weak, abundant expectoration, and with tinnitus, perspiration, feel sick, vomiting, the symptom such as nervous, uncomfortable in chest, through EEG (electrocardiogram) examination, see epileptiform discharge, and according to the traditional Chinese medical science, hope, hear, ask, cut the dialectical wind-phlegm that is further diagnosed as and hinder closed form epilepsia vertiginosa disease.120 routine patients are divided into three groups at random, are respectively embodiment group 1, embodiment group 2 and matched group, every group of 40 routine patients, each experimental group patient is at age, sex, the tumor state of an illness and chemicotherapy equal no significant difference aspect the cycle.

Therapeutic Method:

Embodiment group 1: use the tablet of the embodiment of the present invention 1 to treat, every day three times, each 4 10 days is a course for the treatment of, takes continuously 2-6 the course for the treatment of;

Embodiment group 2: use the granule of the embodiment of the present invention 2, every day three times, each 12g, 10 days is a course for the treatment of, takes continuously 2-6 the course for the treatment of;

Matched group: use phenobarbitone tablet, every day three times, each 15-30mg, 10 days is a course for the treatment of, takes continuously 2-6 the course for the treatment of.

Diagnostic criteria: clinical cure: treatment finishes no longer to occur onset of vertigo in latter 3 months, other symptoms also disappear, and electroencephalogram check three times is all normal; Effective: treatment finishes to occur for latter 3 months that onset of vertigo number of times obviously reduces, can orthobiosis and work; Effective: treatment finishes to occur for latter 3 months that onset of vertigo number of times reduces, though orthobiosis live and work is had to impact; Invalid: symptom does not alleviate even and increases the weight of.

Therapeutic outcome:

Referring to table 1 and table 2, as can be seen from Table 1, adopt medicine of the present invention to be used for the treatment of wind-phlegm resistance closed form epilepsia vertiginosa sick, with respect to conventional medicament, on therapeutic effect, there is marked improvement; As can be seen from Table 2, adopt medicine of the present invention to be used for the treatment of wind-phlegm resistance closed form epilepsia vertiginosa sick, with respect to conventional medicament, treating significantly shortening on the course for the treatment of.

After each experimental group of table 1 is treated respectively 2-6 the course for the treatment of, Clinical efficacy comparison is routine

Group	Number of cases	Clinical cure	Effective	Effectively	Invalid	Cure and obvious effective rate	Total effective rate
								Embodiment group 1	40	14	18	6	2	（32）80.0%	95%
Embodiment group 2	40	16	18	6	0	（32）85.0%	100%
								Matched group	40	5	16	11	8	（21）52.5%	80%

Table 2 liang group is cured and effective number and time comparative example (%) after treating respectively 2-6 the course for the treatment of

Group	Number of cases	2-3 the course for the treatment of	4-5 the course for the treatment of	The 6th course for the treatment of
					Embodiment group 1	32	6(18.8%)	19(59.4%)	7(21.9%)
Embodiment group 2	34	8(23.5%)	20(58.8%)	6(17.6%)
					Matched group	21	3(14.3%)	8(38.1%)	10(47.6%)

Known according to the clinical statistics in above table, that Chinese medicine provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect; In therapeutic process, to find that the patient of matched group there will be the side effect such as cognitive and memory defects, and obviously find the prolongation along with Time of Administration, drug effect obviously declines.The patient of each experimental group is followed up a case by regular visits to 1 year result statistics: embodiment group 1 is cured and be effective 32, and 14 examples of clinical cure have 1 example to recur simultaneously, 1 case relapsed in 18 effective routine patients, relapse rate is 6.25%; Embodiment group 2 is cured and is effective 34, and 16 examples of clinical cure are without recurring, 1 case relapsed in 18 effective routine patients, and relapse rate is 2.94%; The routine patient of matched group 21, in 5 routine patients of healing, recurrence 1 people, in 16 effective routine patients, recurrence 7 people, relapse rate 38.1%.

Model case

Lin, man, 31 years old, with episodic vertigo, go to a doctor, continue to go to a doctor before half a year, according to describing patient, without inducement, occur episodic vertigo, conscious levitation, top-heavy, feels sick sometimes, weak, abundant expectoration, through EEG (electrocardiogram) examination, see epileptiform discharge, and pale tongue, tongue is greasy in vain, and the many stringy and rolling pulse of arteries and veins are strong.Be diagnosed as wind-phlegm resistance closed form epilepsia vertiginosa sick, use the granule of the embodiment of the present invention 2, every day three times, each 12g, 10 days is a course for the treatment of, takes continuously 3 courses for the treatment of, takes a turn for the better to some extent, continues to take 3 courses for the treatment of, and recovery from illness, follows up a case by regular visits to 1 year, not recurrence.

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims

1. the medicine that is used for the treatment of wind-phlegm resistance closed form epilepsia vertiginosa disease, it is characterized in that, described medicine comprises following raw medicinal material: Pericarpium Citri Reticulatae, Uncaria tonkinensis Havil., Aeschna melanictera, Cortex Juglandis mandshuricae, Flos Rosae Rugosae, FLOS MUME, Semen Aesculi, Calyx Kaki, Semen Sinapis Albae, Radix Salviae Miltiorrhizae, Flos Inulae, Succus Bambusae, Concretio Silicea Bambusae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Concha Meretricis seu Cyclinae, Radix Ranunculi Ternati, Fructus Trichosanthis, Armillariella mellea, Semen Sesami Nigrum, Folium Rhododendri Daurici, Flos Lonicerae, Ramulus Uncariae Cum Uncis, Margarita, Rhizoma Gastrodiae, Pheretima, Bombyx Batryticatus, Rhizoma Acori Graminei, Rhizoma Zingiberis Recens, Folium hydrangeae strigosae rattan and DAWANHUA.

2. the medicine that is used for the treatment of wind-phlegm resistance closed form epilepsia vertiginosa disease according to claim 1, is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Pericarpium Citri Reticulatae 10-25 weight portion, Uncaria tonkinensis Havil. 10-20 weight portion, Aeschna melanictera 10-20 weight portion, Cortex Juglandis mandshuricae 10-20 weight portion, Flos Rosae Rugosae 15-25 weight portion, FLOS MUME 10-15 weight portion, Semen Aesculi 10-20 weight portion, Calyx Kaki 15-20 weight portion, Semen Sinapis Albae 10-20 weight portion, Radix Salviae Miltiorrhizae 10-20 weight portion, Flos Inulae 10-15 weight portion, Succus Bambusae 15-20 weight portion, Concretio Silicea Bambusae 15-20 weight portion, Sargassum 15-20 weight portion, Thallus Laminariae (Thallus Eckloniae) 10-15 weight portion, Concha Meretricis seu Cyclinae 10-15 weight portion, Radix Ranunculi Ternati 10-20 weight portion, Fructus Trichosanthis 10-20 weight portion, Armillariella mellea 10-20 weight portion, Semen Sesami Nigrum 5-10 weight portion, Folium Rhododendri Daurici 10-15 weight portion, Flos Lonicerae 10-15 weight portion, Ramulus Uncariae Cum Uncis 10-20 weight portion, Margarita 10-20 weight portion, Rhizoma Gastrodiae 10-15 weight portion, Pheretima 10-15 weight portion, Bombyx Batryticatus 15-25 weight portion, Rhizoma Acori Graminei 10-20 weight portion, Rhizoma Zingiberis Recens 15-20 weight portion, Folium hydrangeae strigosae rattan 10-20 weight portion and DAWANHUA 10-20 weight portion.

3. the medicine that is used for the treatment of wind-phlegm resistance closed form epilepsia vertiginosa disease according to claim 1 and 2, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Pericarpium Citri Reticulatae 18 weight portions, Uncaria tonkinensis Havil. 15 weight portions, Aeschna melanictera 15 weight portions, Cortex Juglandis mandshuricae 15 weight portions, Flos Rosae Rugosae 19 weight portions, FLOS MUME 12 weight portions, Semen Aesculi 15 weight portions, Calyx Kaki 17 weight portions, Semen Sinapis Albae 15 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Flos Inulae 12 weight portions, Succus Bambusae 17 weight portions, Concretio Silicea Bambusae 18 weight portions, Sargassum 18 weight portions, Thallus Laminariae (Thallus Eckloniae) 12 weight portions, Concha Meretricis seu Cyclinae 12 weight portions, Radix Ranunculi Ternati 15 weight portions, Fructus Trichosanthis 15 weight portions, Armillariella mellea 15 weight portions, Semen Sesami Nigrum 12 weight portions, Folium Rhododendri Daurici 12 weight portions, Flos Lonicerae 14 weight portions, Ramulus Uncariae Cum Uncis 15 weight portions, Margarita 15 weight portions, Rhizoma Gastrodiae 12 weight portions, Pheretima 12 weight portions, Bombyx Batryticatus 21 weight portions, Rhizoma Acori Graminei 15 weight portions, Rhizoma Zingiberis Recens 19 weight portions, Folium hydrangeae strigosae rattan 15 weight portions and DAWANHUA 15 weight portions.

4. according to the medicine that is used for the treatment of wind-phlegm resistance closed form epilepsia vertiginosa disease described in claim 1-3 any one, it is characterized in that, described medicine also comprises: Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata, Rhizoma Dioscoreae, Cortex Magnoliae Officinalis and Fructus Jujubae.

5. according to the medicine that is used for the treatment of wind-phlegm resistance closed form epilepsia vertiginosa disease described in claim 1-4 any one, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Pericarpium Citri Reticulatae 10-25 weight portion, Uncaria tonkinensis Havil. 10-20 weight portion, Aeschna melanictera 10-20 weight portion, Cortex Juglandis mandshuricae 10-20 weight portion, Flos Rosae Rugosae 15-25 weight portion, FLOS MUME 10-15 weight portion, Semen Aesculi 10-20 weight portion, Calyx Kaki 15-20 weight portion, Semen Sinapis Albae 10-20 weight portion, Radix Salviae Miltiorrhizae 10-20 weight portion, Flos Inulae 10-15 weight portion, Succus Bambusae 15-20 weight portion, Concretio Silicea Bambusae 15-20 weight portion, Sargassum 15-20 weight portion, Thallus Laminariae (Thallus Eckloniae) 10-15 weight portion, Concha Meretricis seu Cyclinae 10-15 weight portion, Radix Ranunculi Ternati 10-20 weight portion, Fructus Trichosanthis 10-20 weight portion, Armillariella mellea 10-20 weight portion, Semen Sesami Nigrum 5-10 weight portion, Folium Rhododendri Daurici 10-15 weight portion, Flos Lonicerae 10-15 weight portion, Ramulus Uncariae Cum Uncis 10-20 weight portion, Margarita 10-20 weight portion, Rhizoma Gastrodiae 10-15 weight portion, Pheretima 10-15 weight portion, Bombyx Batryticatus 15-25 weight portion, Rhizoma Acori Graminei 10-20 weight portion, Rhizoma Zingiberis Recens 15-20 weight portion, Folium hydrangeae strigosae rattan 10-20 weight portion, DAWANHUA 10-20 weight portion, Endothelium Corneum Gigeriae Galli 15-20 weight portion, Massa Medicata Fermentata 10-15 weight portion, Rhizoma Dioscoreae 15-20 weight portion, Cortex Magnoliae Officinalis 10-15 weight portion and Fructus Jujubae 15-20 weight portion.

6. according to the medicine that is used for the treatment of wind-phlegm resistance closed form epilepsia vertiginosa disease described in claim 1-5 any one, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Pericarpium Citri Reticulatae 21 weight portions, Uncaria tonkinensis Havil. 14 weight portions, Aeschna melanictera 15 weight portions, Cortex Juglandis mandshuricae 17 weight portions, Flos Rosae Rugosae 19 weight portions, FLOS MUME 12 weight portions, Semen Aesculi 15 weight portions, Calyx Kaki 18 weight portions, Semen Sinapis Albae 15 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Flos Inulae 12 weight portions, Succus Bambusae 18 weight portions, Concretio Silicea Bambusae 18 weight portions, Sargassum 17 weight portions, Thallus Laminariae (Thallus Eckloniae) 12 weight portions, Concha Meretricis seu Cyclinae 12 weight portions, Radix Ranunculi Ternati 15 weight portions, Fructus Trichosanthis 15 weight portions, Armillariella mellea 18 weight portions, Semen Sesami Nigrum 8 weight portions, Folium Rhododendri Daurici 13 weight portions, Flos Lonicerae 15 weight portions, Ramulus Uncariae Cum Uncis 15 weight portions, Margarita 16 weight portions, Rhizoma Gastrodiae 14 weight portions, Pheretima 12 weight portions, Bombyx Batryticatus 20 weight portions, Rhizoma Acori Graminei 15 weight portions, Rhizoma Zingiberis Recens 18 weight portions, Folium hydrangeae strigosae rattan 15 weight portions, DAWANHUA 15 weight portions, Endothelium Corneum Gigeriae Galli 17 weight portions, Massa Medicata Fermentata 12 weight portions, Rhizoma Dioscoreae 18 weight portions, Cortex Magnoliae Officinalis 14 weight portions and Fructus Jujubae 19 weight portions.

7. according to the preparation method of the medicine that is used for the treatment of wind-phlegm resistance closed form epilepsia vertiginosa disease described in claim 1-6 any one, it is characterized in that, the dosage form of described medicine is tablet, and its preparation method comprises the following steps:

8. according to the preparation method of the medicine that is used for the treatment of wind-phlegm resistance closed form epilepsia vertiginosa disease described in claim 1-6 any one, it is characterized in that, the dosage form of described medicine is granule, and its preparation method comprises the following steps: