CN105663193B - Rice washing water prepared pseudo-ginseng powder as well as preparation and preparation method thereof - Google Patents
Rice washing water prepared pseudo-ginseng powder as well as preparation and preparation method thereof Download PDFInfo
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- CN105663193B CN105663193B CN201610123232.5A CN201610123232A CN105663193B CN 105663193 B CN105663193 B CN 105663193B CN 201610123232 A CN201610123232 A CN 201610123232A CN 105663193 B CN105663193 B CN 105663193B
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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Abstract
The invention provides rice washing water prepared pseudo-ginseng powder as well as a preparation and a preparation method thereof. The rice washing water prepared pseudo-ginseng powder is prepared from the following ingredients in parts by weight: 5-100 parts of pseudo-ginseng and 5-100 parts of rice washing water, preferably 20-100 parts of pseudo-ginseng and 5-80 parts of rice washing water, more preferably 30-70 parts of pseudo-ginseng and 40-80 parts of rice washing water, and most preferably 40-70 parts of pseudo-ginseng and 50-70 parts of rice washing water. The rice washing water prepared pseudo-ginseng powder can improve the side effects of thirst, constipation, weakness of limbs, fever and the like caused by taking pseudo-ginseng, and can increase the effects of strengthening the middle-jiao, strengthening the spleen, harmonizing the stomach and lubricating the intestines.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of water in which rice has been washed Radix Notoginseng powder and its preparation and preparation side
Method.
Background technology
Pseudo-ginseng also known as pseudo-ginseng, the dry root of panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen
And rhizome, main product is in Yunnan Wenshan Prefecture, therefore named mountain of papers pseudo-ginseng.Chinese medicine pseudo-ginseng is using its root as medicinal effects, with scattered
The effect of stasis of blood hemostasis, detumescence ding-tong.
Sweet, slight bitter, temperature.Effect, dissipate stasis of blood hemostasis, detumescence ding-tong.Cure mainly for spitting blood, spit blood, bleeding from five sense organs or subcutaneous tissue is had blood in stool, uterine bleeding,
Traumatism and bleeding, chest and abdomen shouting pain, tumbling and swelling.
A large amount of medical researches prove, pseudo-ginseng can be used to treating traumatism and bleeding, hemostasis, gastrorrhagia, hematuria etc. it is various it is inside and outside go out
Mass formed by blood stasis；Expansion of blood vessels, thrombus improve microcirculation, prevention and treatment high fat of blood, cholesterol increase, coronary heart diseases and angina pectoris,
The cardiovascular and cerebrovascular diseases such as apoplexy sequela；The hepatopathys such as fatty liver, liver fibrosis and lose blood, postpartum, the reason such as prolonged illness cause
Body void card.Pseudo-ginseng is suppressing anticancer, anti-oxidant whitening to cardiovascular system, to body material's metabolism, to nervous system, auxiliary
The colour of skin, anti-aging and help many-sided pharmacological action such as strong, makes it extensively should preventing and treating various diseases, health care aspect
With.
But because pseudo-ginseng is warm in nature, most people hinder body fluid taking pseudo-ginseng easily consumption, cause the disease of the deficiency of Yin, occur it is thirsty,
The side effects such as constipation, weakness of limbs, heating.
The content of the invention
In order to solve technical problem present in prior art, the invention provides a kind of water in which rice has been washed Radix Notoginseng powder and its system
Agent, can both improve and take the aspect side effect such as the thirsty of generation, constipation, weakness of limbs, heating after pseudo-ginseng, and benefit can be increased again
In, invigorating the spleen and stomach, effect of laxation.The present invention is realized by following technical scheme：
First, the invention provides a kind of water in which rice has been washed Radix Notoginseng powder, its be by following component by ratio of weight and the number of copies made by：
Pseudo-ginseng 5～100, water in which rice has been washed 5～100；It is preferred that 20～100 parts of pseudo-ginseng, 5～80 parts of water in which rice has been washed；More preferably pseudo-ginseng 30
～70 parts, 40～80 parts of water in which rice has been washed；Most preferably 40～70 parts of pseudo-ginseng, 50～70 parts of water in which rice has been washed.
The water in which rice has been washed Radix Notoginseng powder of the present invention is prepared by the method for comprising the steps：
1）It is meal that pseudo-ginseng cleaning is smashed；
2）The water in which rice has been washed that the clear water elutriation of selection rice obtains white opacity is standby；
3）Pseudo-ginseng meal after smashing is put into into step 2）In the water in which rice has been washed of preparation temperature control 5～25 DEG C leaching system 2～
48 hours, period stirred 1 time every 6 hours so as to is evenly distributed, is impregnated with pseudo-ginseng particle and fully absorbs water in which rice has been washed；
4）Notoginseng drying after leaching is made is to water content below 15%；
5）By step 4）Dry pseudo-ginseng is crushed and is obtained final product for impalpable powder.
Secondly, present invention also offers a kind of Chinese medicine preparation, it includes above-mentioned water in which rice has been washed Radix Notoginseng powder.
Further, the preparation method of water in which rice has been washed Radix Notoginseng powder is additionally provided, is comprised the steps：
1）It is meal that pseudo-ginseng cleaning is smashed；
2）The water in which rice has been washed that the clear water elutriation of selection rice obtains white opacity is standby；
3）Pseudo-ginseng meal after smashing is put into into step 2）In the water in which rice has been washed of preparation temperature control 5～25 DEG C leaching system 2～
48 hours, period stirred 1 time every 6 hours so as to is evenly distributed, is impregnated with pseudo-ginseng particle and fully absorbs water in which rice has been washed；
4）Notoginseng drying after leaching is made is to water content below 15%；
5）By step 4）Dry pseudo-ginseng is crushed and is obtained final product for impalpable powder.
Pharmacological effect side's solution of water in which rice has been washed Radix Notoginseng powder of the present invention is as follows：
Pseudo-ginseng：Nature and flavor are sweet, slight bitter, temperature, return through Return liver, stomach.The effect of with dissipate stasis of blood hemostasis, detumescence ding-tong.Cure mainly and cough up
Blood, spits blood, and bleeding from five sense organs or subcutaneous tissue is had blood in stool, and uterine bleeding, traumatism and bleeding, chest and abdomen shouting pain is fallen servant and swollen and ache.Just it is acknowledged as with significant since ancient times
Promoting blood circulation and removing blood stasis, detumescence ding-tong effect, the good reputation with " invaluable ", " southern part of the country god grass ".Spitting of blood is cured mainly, is spitted blood, bleeding from five sense organs or subcutaneous tissue, just
Blood, uterine bleeding, traumatism and bleeding, chest and abdomen shouting pain, tumbling and swelling.
Water in which rice has been washed：Nature and flavor are sweet, cool, nontoxic.Can be used for process medicine, can go it is dry and in and laxation effect, function of spleen and stomach regulating, clearly
Heat stops the effects such as polydipsia, diuresis, cool blood, removing toxic substances.
Present inventors have surprisingly found that, using the cool property of water in which rice has been washed, go it is dry and in effect can reduce pseudo-ginseng warm it is dry
Property, improve thirsty, constipation, etc. side effect.Therefore, the positive effect of the present invention is：The present invention is foundation theory of traditional Chinese medical science basis,
Using said medicine compatibility, pseudo-ginseng and water in which rice has been washed mutual restraint between two drugs are made, using cool property and the warm for going dry function to reduce pseudo-ginseng of water in which rice has been washed
Dry property, improves the side effects such as thirsty, constipation, dysphoria with smothery sensation.And prove effective jointly, heat is not dry while dissipate stasis of blood hemostasis to make pseudo-ginseng
Fire, while the bitter taste mouthfeel for improving pseudo-ginseng makes people be easier to take.
Specific embodiment
Embodiments below and case application, are only intended to clearly illustrate example of the present invention, and not to this
The restriction of invention.For those of ordinary skill in the art, other can also be made not on the basis of the above description
With the change or variation of form.And the obvious change thus amplified out or change still in protection scope of the present invention
Among.
Embodiment 1：
The preparation method of water in which rice has been washed Radix Notoginseng powder is as follows：
1st, 50g pseudo-ginsengs are taken, the removal of impurity is smashed as meal, the drying 1 hour of 30 DEG C of Jing low temperature, is dried to water content
20%；
2nd, choosing 30g rice adds 300g clear water to wash by rubbing with the hands repeatedly, filters and obtains water in which rice has been washed；
3rd, the pseudo-ginseng raw material being dried step 1 is placed in water in which rice has been washed and stirs in 25 DEG C of constant temperature leaching system 8 hours, and period is every
Stirred 1 time every 4 hours so as to be evenly distributed, be impregnated with pseudo-ginseng and fully absorb water in which rice has been washed；
4th, the pseudo-ginseng that step 3 process is obtained is placed in low-temperature vacuum drying case, the drying 3 hours of 30 DEG C of Jing low temperature is dried
To water content 15%,
5th, smash and obtained final product for impalpable powder.
Embodiment 2：
The preparation method of water in which rice has been washed Radix Notoginseng powder is as follows：
1st, 300g pseudo-ginsengs are taken, the removal of impurity is smashed as meal, the drying 1 hour of 30 DEG C of Jing low temperature, is dried to water content
20%；
2nd, choosing 150g rice adds 1000g clear water to wash by rubbing with the hands repeatedly, filters and obtains water in which rice has been washed；
3rd, the pseudo-ginseng raw material being dried step 1 is placed in water in which rice has been washed and stirs in 22 DEG C of constant temperature leaching system 12 hours, period
Stirred 1 time every 4 hours so as to be evenly distributed, be impregnated with pseudo-ginseng and fully absorb water in which rice has been washed；
4th, the pseudo-ginseng that step 3 process is obtained is placed in low-temperature vacuum drying case, the drying 5 hours of 23 DEG C of Jing low temperature is dried
To water content 13%；
5th, smash and obtained final product for impalpable powder.
Embodiment 3：
The preparation method of water in which rice has been washed Radix Notoginseng powder is as follows：
1st, 100g pseudo-ginsengs are taken, the removal of impurity is smashed as meal, the drying 1 hour of 28 DEG C of Jing low temperature, is dried to water content
20%；
2nd, choosing 60g rice adds 700g clear water to wash by rubbing with the hands repeatedly, filters and obtains water in which rice has been washed；
3rd, the pseudo-ginseng raw material being dried step 1 is placed in water in which rice has been washed and stirs in 18 DEG C of constant temperature leaching system 8 hours, and period is every
Stirred 1 time every 4 hours so as to be evenly distributed, be impregnated with pseudo-ginseng and fully absorb water in which rice has been washed；
4th, the pseudo-ginseng that step 3 process is obtained is placed in low-temperature vacuum drying case, the drying 2 hours of 25 DEG C of Jing low temperature is dried
To water content 14%；
5th, smash and obtained final product for impalpable powder.
Test example 1：Pharmacodynamics
To prove that the validity of the invention has carried out pharmacological evaluation in terms of pharmacodynamics, it is reported as follows：
1st, test material
1-1 medicines：Primary Radix Notoginseng powder and water in which rice has been washed Radix Notoginseng powder, by Jilin Province north domain, American Ginseng research Co., Ltd carries
For lot number 20151201.Dosage setting by people and animal body surface area equivalent dosage conversions, people's daily maximum dose level（9g/
60kg）Equivalent to mouse 1.2g/kg.Therefore this test primary Radix Notoginseng powder of setting mouse and water in which rice has been washed Radix Notoginseng powder dosage be 0.6,
1.2nd, 2.4g/kg groups, desired concn is configured to during test with 0.5% sodium carboxymethylcellulose.
1-2 animal ICR mouse, 18～22g of body weight, quality certification number：SCXK（It is lucky）2015-0003, is asked in vain by Jilin University
The animal experimental center supply of grace medical college.Raise ground：Bethune medical college of Jilin University animal experimental center.
2nd, test method
ICR mouse 140,18～22g, male and female half and half.7 groups are randomly divided into by sex, body weight, i.e.,：Control group, primary three
The basic, normal, high dosage group of seven powder and the basic, normal, high dosage group of water in which rice has been washed Radix Notoginseng powder, every group of male and female are each 10.Gavage capacity is
20ml/kg, one time a day, continuous 30 days.In administration 30 days, the equal lumbar injection yellow Jackets 50mg/kg of each group mouse, record
The incubation period slept in 30 minutes and the length of one's sleep.
3rd, observation index
Each group observes respectively lower index for 10,20,30 days in administration：
（1）Autonomic activities situation in mouse 10 minutes；
（2）Mouse symptom and sign：The expression of animal, activity（Grab nose, itch etc.）Situation；
（3）The mouse amount of drinking water of 24 hours, urine volume and color, excrement shape etc. change.
4th, result of the test
Mouse autonomic activities is observed respectively within 10,20,30 days, compare with control group, middle and high dose of primary Radix Notoginseng powder in administration
Amount group can substantially increase mouse autonomic activities number of times（p<0.05）, the basic, normal, high dosage group of water in which rice has been washed Radix Notoginseng powder has no obvious
Difference（p>0.05）, it is shown in Table 1.
Mouse amount of drinking water and urine volume situation of change are observed respectively within 10,20,30 days, compare with control group, primary three in administration
The middle and high dosage group of seven powder can substantially increase mouse amount of drinking water and urine volume in 20,30 days in administration（p<0.05）, water in which rice has been washed system three
The basic, normal, high dosage group of seven powder has no notable difference（p>0.05）, it is shown in Table 2.
In administration mouse urine volume color, excrement shape, the expression of animal, activity are observed respectively within 10,20,30 days（Grab nose,
Itch etc.）Situation, compares with control group, and the visible mouse expression of the middle and high dosage group of primary Radix Notoginseng powder is irritated, and activity increases, urine volume
Increase, darken, excrement is excluded and reduced, and shape is hard, and the basic, normal, high dosage group of water in which rice has been washed Radix Notoginseng powder has no notable difference,
It is shown in Table 3.
Compare with control group, * p<0.05
Compare with control group, * p<0.05.
Compare with control group, * p<0.05
5th, conclusion (of pressure testing)
Primary Radix Notoginseng powder can substantially increase mouse autonomic activities number of times, hence it is evident that increase mouse amount of drinking water and urine volume, can make little
Mouse expression is irritated, and activity increases, and hydrouria darkens, and excrement is excluded and reduced, and shape is hard, points out primary Radix Notoginseng powder to connect
It is continuous oral 1 month, animal can be made thirsty, dysphoria with smothery sensation, constipation side effect occur.Continuous oral of the present invention 1 month, has no obvious animal
There is thirsty, dysphoria with smothery sensation, constipation side effect.
Test example 2：Typical case
1st, certain man, 57 years old, tcm diagnosis：The obstruction of qi in the chest, tongue with ecchymosis, angina pectoris.
Treatment：Take primary Radix Notoginseng powder after 1 week symptom be obviously improved, but there is dysphoria with smothery sensation, thirsty, constipation symptom.After use
Water in which rice has been washed Radix Notoginseng powder prepared by the embodiment of the present invention 1, often takes 3 grams, and 3 times a day.
Effect：Use instead and improve dysphoria with smothery sensation, thirsty, constipation symptom after present invention Radix Notoginseng powder processed, then after continuously taking 21 days
Do not occur any side effect yet, Angina rate is significantly reduced.
2nd, certain female, 49 years old, diagnosis：Shank tumble injury, bone split and with subcutaneous hemorrhage.
Treatment：Taken with Radix Notoginseng powder grinding, compatibility corydalis tuber, safflower, almond.2 doses are taken, rear hemostasis substantially disappears, ached
Pain mitigates, but occurs in that thirsty, constipation side effect that pseudo-ginseng causes.
Effect：Subsequently use primary Radix Notoginseng powder instead in the embodiment of the present invention 2 water in which rice has been washed Radix Notoginseng powder for preparing, 2 doses of deutostomas
Yearningly, constipation symptom disappears.Continuously take March check recovery from illness.
3rd, certain man, diagnoses for 16 years old：The normal nosebleeds of Jing.
Treatment：Radix Notoginseng powder is individually taken, 3 times a day, each 3g, after continuously taking 2 weeks, serious constipation occur, while
With thirsty, dysphoria with smothery sensation side reaction is particularly evening and increases.
Effect：Afterwards by primary Radix Notoginseng powder this with the water in which rice has been washed Radix Notoginseng powder in the embodiment of the present invention 3, it is constipation, dysphoria with smothery sensation, thirsty
Side reaction disappears, and does not occur any side effect, and the non-bleeding of nose after continuously taking 21 days yet, fully recovers.
Claims (1)
1. a kind of preparation method of water in which rice has been washed Radix Notoginseng powder, it is characterised in that step is as follows：
1) 50g pseudo-ginsengs, are taken, the removal of impurity is smashed as meal, the drying 1 hour of 30 DEG C of Jing low temperature, is dried to water content 20%；
2), choosing 30g rice adds 300g clear water to wash by rubbing with the hands repeatedly, filters and obtains water in which rice has been washed；
3), by step 1) the pseudo-ginseng raw material that is dried is placed in water in which rice has been washed and stirs in 25 DEG C of constant temperature leaching system 8 hours, period every
Stir 1 time within 4 hours so as to be evenly distributed, be impregnated with pseudo-ginseng and fully absorb water in which rice has been washed；
4), by step 3) process the pseudo-ginseng that obtains and be placed in low-temperature vacuum drying case, the drying 3 hours of 30 DEG C of Jing low temperature is dried extremely
Water content 15%；
5), smash and obtained final product for impalpable powder.
2. a kind of preparation method of water in which rice has been washed Radix Notoginseng powder, it is characterised in that step is as follows：
1) 300g pseudo-ginsengs, are taken, the removal of impurity is smashed as meal, the drying 1 hour of 30 DEG C of Jing low temperature, is dried to water content 20%；
2), choosing 150g rice adds 1000g clear water to wash by rubbing with the hands repeatedly, filters and obtains water in which rice has been washed；
3), by step 1) the pseudo-ginseng raw material that is dried is placed in water in which rice has been washed and stirs in 22 DEG C of constant temperature leaching system 12 hours, and period is every
Stirred 1 time every 4 hours so as to be evenly distributed, be impregnated with pseudo-ginseng and fully absorb water in which rice has been washed；
4), by step 3) process the pseudo-ginseng that obtains and be placed in low-temperature vacuum drying case, the drying 5 hours of 23 DEG C of Jing low temperature is dried extremely
Water content 13%；
5), smash and obtained final product for impalpable powder.
3. a kind of preparation method of water in which rice has been washed Radix Notoginseng powder, it is characterised in that step is as follows：
1) 100g pseudo-ginsengs, are taken, the removal of impurity is smashed as meal, the drying 1 hour of 28 DEG C of Jing low temperature, is dried to water content 20%；
2), choosing 60g rice adds 700g clear water to wash by rubbing with the hands repeatedly, filters and obtains water in which rice has been washed；
3), by step 1) the pseudo-ginseng raw material that is dried is placed in water in which rice has been washed and stirs in 18 DEG C of constant temperature leaching system 8 hours, period every
Stir 1 time within 4 hours so as to be evenly distributed, be impregnated with pseudo-ginseng and fully absorb water in which rice has been washed；
4), by step 3) process the pseudo-ginseng that obtains and be placed in low-temperature vacuum drying case, the drying 2 hours of 25 DEG C of Jing low temperature is dried extremely
Water content 14%；
5), smash and obtained final product for impalpable powder.
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| CN108938695A (en) * | 2018-08-01 | 2018-12-07 | 安徽金国源中药股份有限公司 | A kind of manufacture craft of ripe Radix Notoginseng powder |
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2016
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Non-Patent Citations (1)
| Title |
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| 米泔水在中药炮制中的古今应用研究;张钰琪;《江西中医药》;20110430;第42卷(第340期);64-66 * |
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