CN106420681A - Massaging gel capable of relieving muscle pain and preparing method thereof - Google Patents
Massaging gel capable of relieving muscle pain and preparing method thereof Download PDFInfo
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- CN106420681A CN106420681A CN201610942291.5A CN201610942291A CN106420681A CN 106420681 A CN106420681 A CN 106420681A CN 201610942291 A CN201610942291 A CN 201610942291A CN 106420681 A CN106420681 A CN 106420681A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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Abstract
The invention discloses a massaging gel capable of relieving muscle pain and a preparing method thereof. The massaging gel is prepared from, by weight, 10-30 parts of menthol, 1-5 parts of camphor, 20-30 parts of isoceteth-20, 40-80 parts of isopropanol, 0.2-2 parts of sodium hydroxide, 1-3 parts of DMDM hydantoin, 3-15 parts of carbomer, 10-30 parts of PEG-40 hydrogenated castor oil and 360-500 parts of purified water. The gel prepared with the method is good in stability, the layered phenomenon can be avoided, and the gel is fine and smooth in texture, even in content, good in coating effect, free of skin stimulation, fresh in smell and controllable in quality; meanwhile, by means of the coordinate effects of all components in the formula, the transdermal permeation effect of the medicine is improved, and the pain and the ache and swelling feelings of muscles are rapidly and effectively relieved.
Description
Technical field
The present invention relates to topical drug field is and in particular to a kind of massage gel alleviating myalgia and its preparation side
Method.
Background technology
In recent years, with economic fast development and growth in the living standard, people also get over for the requirement of quality of life
Come higher, also more focus on health care at ordinary times simultaneously, with the increasing of frequently and at ordinary times exercise of the number of travels that goes on a tour,
The pain occurring for muscle and sour swollen phenomenon are it would be desirable to rapidly being alleviated or being eliminated, and the gel of the present invention just may be used
To reach this requirement, the swelling and pain sense of muscle can be obviously improved after use, certain reducing swelling and alleviating pain can be played simultaneously
Antipruritic effect.
Mentholum is colourless needles or prism-shaped crystallization or white crystalline powder, has the special aroma of Herba Menthae, in medicine
Above it is used as excitantss, acts on skin or mucosa, have refrigerant itching-relieving action, Herba Menthae brain-capacity optionally stimulates human body skin or glutinous
The Cold receptor of film, produces sense of cold reflection and creeping chill, causes skin mucosa vasoconstriction（Actually skin keeps normal）；Separately
The outer blood vessel to deep tissue also can cause contraction, and produces therapeutical effect, and external can be with antiinflammatory, pain relieving, antipruritic, drives mosquito
Worm, blood circulation promoting, detumescence etc..
Camphora is branch, dry, leaf and the root of canella Camphor tree, and through refining the crystalline particulate being obtained, Camphora has clearance
Key, qi stagnation removing, ward off foul, killing parasites for relieving itching, reducing swelling and alleviating pain effect, cure mainly the symptoms such as scabies prurituss, traumatic pain；Mentholum is normal
Share with Camphora, the effect of antipruritic pain relieving can be strengthened.
Gel is that a kind of semi-solid jelly comprising liquid containing more than two kinds or two kinds of components is dried system with it（Dry
Glue）Macromolecular network system common name, it has good biocompatibility, drug release is had slow-release controlled-release effect,
And good looking appearance is easy to be coated with, easily absorb after local application, good stability, action effect is better than general cream Emulsion.
Content of the invention
Present invention purpose is to solve real-life problem, provides a kind of massage alleviating myalgia to coagulate
Glue and preparation method thereof, overcomes the shortcomings of that prior art exists.
To achieve these goals, the present invention adopts the following technical scheme that：
The massage gel of myalgia can be alleviated, by weight, described massage gel contains Mentholum 10-30 weight portion,
Camphora 1-5 weight portion, different ceteth -20 20-30 weight portion, isopropanol 40-80 weight portion, sodium hydroxide 0.2-2 weight
Amount part, DMDM Hydantoin 1-3 weight portion, Carbomer 3-15 weight portion, Cremophor RH40 10-30 weight portion is pure
Change water 360-500 weight portion.
The preparation method of the massage gel of myalgia can be alleviated, including herein below：
（1）The preparation of aqueous phase substrate：Weigh the Carbomer of recipe quantity, soak 24h with the purified water of recipe quantity, cross 40 eye mesh screens,
Again carbomer solution is poured in beaker, be warming up to 70 DEG C, be incubated 5min；
（2）The preparation of oil phase substrate：Weigh Cremophor RH40 by recipe quantity, different ceteth -20, in 70 DEG C of water-baths
Heating, melting clarification, it is incubated 30min；
（3）Principal agent solution is prepared：Weigh Mentholum, Camphora by recipe quantity, with the isopropanol dissolving of recipe quantity, stir；
（4）The preparation of pH adjustment agent：Prepare 10% sodium hydroxide solution, standby；
（5）Oil phase substrate is slowly added to aqueous phase substrate, stir 15min with 180rpm rotating speed, using emulsification pretreatment machine
Emulsifying 5min, is cooled to 40 DEG C, adds DMDM Hydantoin, principal agent solution, continues to stir 15min with 300rpm rotating speed, adds
10% sodium hydroxide solution, stirs to transparent or semitransparent gel, obtains final product.
Beneficial effects of the present invention：
The present invention adds principal agent after lowering the temperature in the case that substrate character is stable, it is to avoid the feature of the effumability of principal agent, really
Protect the content accuracy of medicine；Adding of different ceteth -20 preferably promotes the dispersed of medicine, improves medicine
Homogeneity；The interpolation of appropriate DMDM Hydantoin extends the storage time of this product；The present invention passes through the coordination of each component in formula
Effect, improves the transdermal penetration effect of medicine, fast and effectively alleviates the pain of muscle and sour swollen sense.
Gel stability according to technical scheme preparation is good simultaneously, will not find lamination, the present invention's
Gel exquisite quality, uniform content, coating effect is good and non-stimulated to skin, and abnormal smells from the patient is pure and fresh, quality controllable.
Specific embodiment
In order that those skilled in the art are better understood by technical scheme, improve with reference to concrete technology
Process is described in further detail.
Embodiment 1：
The massage gel of myalgia can be alleviated, 100g includes following component：Mentholum 2.5g, Camphora 0.5g, different spermol
Polyethers -20 4g, isopropanol 10g, sodium hydroxide 0.5g, DMDM Hydantoin 0.5g, Carbomer 1g, Cremophor RH40
6g, purified water 75g.
The preparation method of the massage gel of myalgia can be alleviated, specific as follows：
（1）The preparation of aqueous phase substrate：Weigh the Carbomer of recipe quantity, soak 24h with the purified water of recipe quantity, cross 40 eye mesh screens,
Standby；
（2）The preparation of oil phase substrate：Weigh Cremophor RH40 by recipe quantity, different ceteth -20, in 70 DEG C of water-baths
Heating, melting clarification, it is incubated 30min；
（3）Principal agent solution is prepared：Weigh Mentholum, Camphora by recipe quantity, with the isopropanol dissolving of recipe quantity, stir；
（4）The preparation of PH adjustment agent：Prepare 10% sodium hydroxide solution, standby；
（5）Oil phase substrate is slowly added to aqueous phase substrate, stir 15min with 180rpm rotating speed, using emulsification pretreatment machine
Emulsifying 5min, is cooled to 40 DEG C, adds DMDM Hydantoin, principal agent solution, continues to stir 15min with 300rpm rotating speed, adds
10% sodium hydroxide solution, stirs to transparent or semitransparent gel, obtains final product.
Embodiment 2：
The massage gel of myalgia can be alleviated, 100g includes following component：Mentholum 3g, Camphora 0.5g, different spermol gather
Ether -20 3g, isopropanol 15g, sodium hydroxide 0.5g, DMDM Hydantoin 0.5g, Carbomer 1g, Cremophor RH40
3g, purified water 73.5g.
The preparation method of the massage gel of myalgia can be alleviated, specific as follows：
（1）The preparation of aqueous phase substrate：Weigh the Carbomer of recipe quantity, soak 24h with the purified water of recipe quantity, cross 40 eye mesh screens,
Standby；
（2）The preparation of oil phase substrate：Weigh Cremophor RH40 by recipe quantity, different ceteth -20, in 70 DEG C of water-baths
Heating, adds 7.5g isopropanol, melting clarification, is incubated 30min；
（3）Principal agent solution is prepared：Weigh Mentholum, Camphora by recipe quantity, with the dissolving of 7.5g isopropanol, stir；
（4）The preparation of PH adjustment agent：Prepare 10% sodium hydroxide solution, standby；
（5）Oil phase substrate is slowly added to aqueous phase substrate, stir 15min with 180rpm rotating speed, using emulsification pretreatment machine
Emulsifying 5min, is cooled to 40 DEG C, adds DMDM Hydantoin, principal agent solution, continues to stir 15min with 300rpm rotating speed, adds
10% sodium hydroxide solution, stirs to transparent or semitransparent gel, obtains final product.
Embodiment 3
The massage gel of myalgia can be alleviated, 100g includes following component：Mentholum 3g, Camphora 0.5g, different spermol gather
Ether -20 2g, isopropanol 15g, sodium hydroxide 0.5g, DMDM Hydantoin 0.5g, Carbomer 0.5g, Cremophor RH40
4g, purified water 74g.
The preparation method of the massage gel of myalgia can be alleviated, specific as follows：
（1）The preparation of aqueous phase substrate：Weigh the Carbomer of recipe quantity, soak 24h with the purified water of recipe quantity, cross 40 eye mesh screens,
Again carbomer solution is poured in beaker, be warming up to 70 DEG C, be incubated 5min；
（2）Prepare 10% sodium hydroxide solution by recipe quantity, be subsequently adding in aqueous phase substrate, stir；
（3）The preparation of oil phase substrate：Weigh Cremophor RH40 by recipe quantity, different ceteth -20, in 70 DEG C of water-baths
Heating, melting clarification, it is incubated 30min；
（4）Principal agent solution is prepared：Weigh Mentholum, Camphora by recipe quantity, with the isopropanol dissolving of recipe quantity, stir；
（5）Oil phase substrate is slowly added to aqueous phase substrate, stir 15min with 180rpm rotating speed, using emulsification pretreatment machine
Emulsifying 5min, is cooled to 40 DEG C, adds DMDM Hydantoin, principal agent solution, continues to stir 15min, stirring with 300rpm rotating speed
To transparent or semitransparent gel, obtain final product.
Experimental result and analysis：
Embodiments of the invention 1 are it is found that the adhesiveness of gel is bad, and Painting effect is undesirable it may be possible to oil phase is in aqueous phase
Dispersion is undesirable to be caused, therefore modified technique embodiment 2, and isopropanol plays oil phase substrate effect of fluxing, it is found that this gel
Painting effect improve, but adhesiveness is still bad, then finds that after repeatedly testing oil phase substrate must at 70 DEG C about
Preservation character that can be best is stable, therefore needs a heated aqueous to 70 DEG C and to be incubated after process modification；The gel of embodiment 3 applies
Cloth effect and adhesiveness are all fine, but have obvious bubble in gel, therefore determine final step again after repeatedly testing
Add PH regulator；Determine after repeatedly improving that the applied for technique of the present invention is optimal.
Above-described embodiment is only in order to illustrate principle and the process modification process of the present invention, not limitation of the present invention.Should
When pointing out, to those skilled in the art, under the premise without departing from the principles of the invention, to it in form or in details
The some improvement made or modification, still in claims of the present invention limited range.
Claims (2)
1. it is characterised in that by weight, described massage gel contains thin a kind of massage gel alleviating myalgia
Lotus brain 10-30 weight portion, Camphora 1-5 weight portion, different ceteth -20 20-30 weight portion, isopropanol 40-80 weight portion,
Sodium hydroxide 0.2-2 weight portion, DMDM Hydantoin 1-3 weight portion, Carbomer 3-15 weight portion, Cremophor RH40
10-30 weight portion, purified water 360-500 weight portion.
2. a kind of preparation method that can alleviate the massage gel of myalgia as claimed in claim 1 is it is characterised in that include
Herein below：
（1）The preparation of aqueous phase substrate：Weigh the Carbomer of recipe quantity, soak 24h with the purified water of recipe quantity, cross 40 eye mesh screens,
Again carbomer solution is poured in beaker, be warming up to 70 DEG C, be incubated 5min；
（2）The preparation of oil phase substrate：Weigh Cremophor RH40 by recipe quantity, different ceteth -20, in 70 DEG C of water-baths
Heating, melting clarification, it is incubated 30min；
（3）Principal agent solution is prepared：Weigh Mentholum, Camphora by recipe quantity, with the isopropanol dissolving of recipe quantity, stir；
（4）The preparation of pH adjustment agent：Prepare 10% sodium hydroxide solution, standby；
（5）Oil phase substrate is slowly added to aqueous phase substrate, stir 15min with 180rpm rotating speed, using emulsification pretreatment machine
Emulsifying 5min, is cooled to 40 DEG C, adds DMDM Hydantoin, principal agent solution, continues to stir 15min with 300rpm rotating speed, adds
10% sodium hydroxide solution, stirs to transparent or semitransparent gel, obtains final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610942291.5A CN106420681A (en) | 2016-11-02 | 2016-11-02 | Massaging gel capable of relieving muscle pain and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610942291.5A CN106420681A (en) | 2016-11-02 | 2016-11-02 | Massaging gel capable of relieving muscle pain and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106420681A true CN106420681A (en) | 2017-02-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610942291.5A Pending CN106420681A (en) | 2016-11-02 | 2016-11-02 | Massaging gel capable of relieving muscle pain and preparing method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN106420681A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111298075A (en) * | 2018-12-12 | 2020-06-19 | 甘肃奇正藏药有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
| CN112957408A (en) * | 2021-02-08 | 2021-06-15 | 北京奇愈生物科技有限公司 | Antibacterial cream for promoting skin healing and preparation method thereof |
| CN115708853A (en) * | 2022-09-08 | 2023-02-24 | 北京微电云芯科技有限公司 | Liquid for treating arthralgia and preparation method thereof |
-
2016
- 2016-11-02 CN CN201610942291.5A patent/CN106420681A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111298075A (en) * | 2018-12-12 | 2020-06-19 | 甘肃奇正藏药有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
| CN111298075B (en) * | 2018-12-12 | 2021-12-31 | 甘肃奇正藏药有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
| CN112957408A (en) * | 2021-02-08 | 2021-06-15 | 北京奇愈生物科技有限公司 | Antibacterial cream for promoting skin healing and preparation method thereof |
| CN115708853A (en) * | 2022-09-08 | 2023-02-24 | 北京微电云芯科技有限公司 | Liquid for treating arthralgia and preparation method thereof |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170222 |
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| RJ01 | Rejection of invention patent application after publication |