CN105106181A - Salicylic acid Pullulan coating agent and preparation method thereof - Google Patents
Salicylic acid Pullulan coating agent and preparation method thereof Download PDFInfo
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- CN105106181A CN105106181A CN201510612015.8A CN201510612015A CN105106181A CN 105106181 A CN105106181 A CN 105106181A CN 201510612015 A CN201510612015 A CN 201510612015A CN 105106181 A CN105106181 A CN 105106181A
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- salicylic acid
- pulullan polysaccharide
- liniment
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Abstract
The invention discloses a salicylic acid Pulullan coating agent which comprises the following components by weight: 40-200 g of salicylic acid, 10-50 g of Pullulan, 5-20 g of polypropylene glycol, 83-125 g of ethylene glycol, 5-10 g of azone, 200-600 g of deionized water, and 500-900 g of ethyl alcohol. A preparation method of the salicylic acid Pulullan coating agent comprises the following specific steps: 1, adding 20 g of Pullulan and 15 g of polypropylene glycol into 400 g of deionized water to be fully dissolved; 2, adding 100 g of ethylene glycol again, and uniformly mixing, so as to obtain a blank coating solution; 3, weighing and dissolving 100 g of salicylic acid into 100 g of an ethyl alcohol solution, adding 8 g of azone again, uniformly mixing, adding the mixture into the blank coating solution, heating, and stirring, so as to obtain a uniform white solution; 4, after the white solution is cooled, adding the ethyl alcohol solution for diluting to 1000 mL. The salicylic acid Pullulan coating agent can be used for treating tinea of feet and hands and tinea cruris, and has the advantages of delaying drug release, achieving long-lasting drug effect and the like.
Description
Technical field
The present invention relates to liniment preparation field, specifically refer to a kind of salicylic acid pulullan polysaccharide liniment and preparation method thereof.
Background technology
Liniment belongs to preparation capable of permeating skin, have preparation technology simple, without the need to framed back material, easy to use, long action time, little without pain, toxic and side effects, the advantage such as to lack without liver first-pass effect, pollution.The substrate of liniment must possess nontoxic, non-stimulated, stable in properties, do not affect pharmaceutically active, not interference body immune function and without conditions such as bad smells.
Pulullan is a kind of natural polysaccharide of colourless, tasteless, odorless, it is nontoxic, safety, plasticity are strong, good film-forming property, heat-resisting, salt tolerant, acid and alkali-resistance and have the feature of adhesion, with the thin film that it makes, there is good mechanical performance, have broad application prospects at field of medicaments.There is more defect in existing Salicylic Acid Formulations, solution is short in the skin time of staying, and carries inconvenience; Powder should not be used there being the dermatosis of sepage or purulent secretion; Ointment is oxidizable to become sour, and not easy cleaning; Liniment is without slow releasing function, and effect is difficult lasting.
Summary of the invention
What the object of the present invention is to provide a kind of brothers' of being used for the treatment of tinea corporis and cruris can delay drug release, obtains lasting drug effect, and without the need to wrapping, easy to use, not pollution clothes, easily by salicylic acid pulullan polysaccharide liniment that patient accepts.
Another object of the present invention is to the preparation method that a kind of salicylic acid pulullan polysaccharide liniment is provided.
The present invention is achieved through the following technical solutions: a kind of salicylic acid pulullan polysaccharide liniment, represents with weight, salicylic acid 40 ~ 200g, pulullan polysaccharide 10 ~ 50g, POLYPROPYLENE GLYCOL 5 ~ 20g, ethylene glycol 83 ~ 125g, azone 5 ~ 10g, deionized water 200 ~ 600g, ethanol 500 ~ 900g forms.
In order to realize the present invention better, the concrete content of each component of restriction further, represents with weight, described salicylic acid 100g, pulullan polysaccharide 20g, POLYPROPYLENE GLYCOL 15g, ethylene glycol 100g, azone 8g, upper deionized water 400g, ethanol 500g.
A preparation method for salicylic acid pulullan polysaccharide liniment, is characterized in that:
(1) take 20g pulullan polysaccharide and 15g POLYPROPYLENE GLYCOL adds in 400g deionized water, soak and heat, making it fully dissolve;
(2) add 100g ethylene glycol wherein again, make its mix homogeneously, obtain blank coating liquid, stand-by;
(3) take salicylic acid 100g to incorporate in 100g alcoholic solution, then add 8g azone, add in blank coating liquid after mixing, heated and stirred, to dissolving completely, obtains uniform white solution;
(4) white solution is placed in the temperature environment of 10 ~ 25 degrees Celsius, add alcoholic solution and be settled to 1000mL, obtain white salicylic acid pulullan polysaccharide liniment.
In order to realize method of the present invention better, further, the whipping process of described step (3) is completed by magnetic stirring apparatus.
In order to realize method of the present invention better, further, in described step (3) in heated and stirred process, add 100g ethanol while hot, make it dissolve more abundant.
In order to realize method of the present invention better, further, the container adding ethanol standardize solution in described step (4) is the beaker of 1500mL.
The present invention compared with prior art, has the following advantages and beneficial effect:
The present invention uses pulullan polysaccharide as the main matrix of salicylic acid liniment, pulullan is a kind of natural polysaccharide of colourless, tasteless, odorless, it is nontoxic, safety, plasticity are strong, good film-forming property, heat-resisting, salt tolerant, acid and alkali-resistance and have the feature of adhesion, with the thin film that it makes, there is good mechanical performance, make the salicylic acid liniment made possess without the need to wrapping, easy to use, not pollution clothes, easily by advantage that patient accepts, and can drug release be delayed, obtain the advantages such as lasting drug effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited thereto, without departing from the idea case in the present invention described above, according to ordinary skill knowledge and customary means, make various replacement and change, all should comprise within the scope of the invention.
Embodiment:
The salicylic acid pulullan polysaccharide liniment of the present embodiment, represents with weight, salicylic acid 100g, pulullan polysaccharide 20g, POLYPROPYLENE GLYCOL 15g, ethylene glycol 100g, azone 8g, upper deionized water 400g, ethanol 500g.
The preparation method of salicylic acid pulullan polysaccharide liniment, comprises the following steps:
(1) take 20g pulullan polysaccharide and 15g POLYPROPYLENE GLYCOL adds in 400g deionized water, soak and heat, making it fully dissolve;
(2) add 100g ethylene glycol wherein again, make its mix homogeneously, obtain blank coating liquid, stand-by;
(3) take salicylic acid 100g to incorporate in 100g alcoholic solution, then add 8g azone, add in blank coating liquid after mixing, heated and stirred, to dissolving completely, obtains uniform white solution;
(4) white solution is placed in the temperature environment of 10 ~ 25 degrees Celsius, add alcoholic solution and be settled to 1000mL, obtain white salicylic acid pulullan polysaccharide liniment.
Wherein, the whipping process of described step (3) is completed by magnetic stirring apparatus, in described step (3) in heated and stirred process, add 100g ethanol while hot, make it dissolve more abundant, the container adding ethanol standardize solution in described step (4) is the beaker of 1500mL.
The film property of single factor exploration pulullan polysaccharide and POLYPROPYLENE GLYCOL, the two film property is good, but film formation time is long.On this basis, select the pulullan polysaccharide of different volumes, POLYPROPYLENE GLYCOL and ethylene glycol solution, the liniment that adding distil water is made altogether carries out orthogonal experiment, using film formation time as evaluation index.The judgement of film formation time quantitatively draws coating liquid with glass pipette to be applied to dry slide surface on a small quantity, when slide surface has medicine crystal to separate out, row dry on film surface with the Glass rod of drying, obtain the cut that edge clear is neat, then judge film forming, record its film formation time.Factor level and Orthogonal experiment results are in table 1 and table 2.
Table 1 factor level table
| factor level | v (pulullan polysaccharide)/mL | v (POLYPROPYLENE GLYCOL)/mL | v (ethylene glycol)/mL |
| 1 | 1 | 3 | 3.6 |
| 2 | 2 | 4 | 0。9 |
| 3 | 3 | 5 | 1。7 |
Table 2 Orthogonal experiment results analytical table
| Numbering | V (pulullan polysaccharide) | V (POLYPROPYLENE GLYCOL) | V (ethylene glycol) | Film formation time/min |
| /mL | /mL | /mL | ||
| 1 | 1 | 1 | 1 | 15 |
| 2 | 1 | 2 | 2 | 14 |
| 3 | 1 | 3 | 3 | 14 |
| 4 | 2 | 1 | 2 | 13 |
| 5 | 2 | 2 | 3 | 8 |
| 6 | 2 | 3 | 1 | 9 |
| 7 | 3 | 1 | 3 | 9 |
| 8 | 3 | 2 | 1 | 8 |
| 9 | 3 | 3 | 2 | 4 |
Pulullan polysaccharide and POLYPROPYLENE GLYCOL are insoluble to ethanol, can produce precipitation when salicylic acid alcoholic solution is joined in matrix mixed solution, and heating can make resolution of precipitate.If standardize solution again after being cooled by solution, then again produce a large amount of precipitation, and heating is not soluble yet.Therefore, first add most of ethanol while hot during standardize solution, be cooled to room temperature after mixing, then add a small amount of ethanol standardize solution, then can obtain uniform solution, if there is a small amount of precipitation, can it be made to dissolve by heating in water bath.Because salicylic acid is oxidizable, cause solution to present lightpink, suppress salicylic oxidation.Azone is conventional Percutaneous absorption enhancer, be made up of the azacyclo-of low pole and non-polar conformations long chain alkane or alkene, the compactness of lipid bilayer can be changed, increase lipid fluidity, and to intracellular proteotoxicity and zest little, therefore the azone added is as promoting the transdermal enhancer of dewatering medicament.In addition the ethylene glycol containing fixed proportion in liniment prescription and ethanol, ethylene glycol belongs to polyhydric alcohol, can be used as transdermal enhancer; Ethanol can disturb cutin tunic tissue, and strengthen lipid fluidity, their combined effect is conducive to salicylic Transdermal absorption.
The salicylic acid pulullan polysaccharide liniment of preparation is coated on skin, the thin film of one deck homogeneous transparent can be formed after 3min, there is good adhesiveness.Carry out skin irritation test to mice and find that mouse back occurs without phenomenons such as vesicle, rash block, rednesses, liniment compares zero difference with bare substrate, illustrate that salicylic acid pulullan polysaccharide liniment is without skin irritation.
Salicylic acid pulullan polysaccharide liniment, overcomes some shortcomings of other preparations of salicylic acid, as: solution is short in the skin time of staying, and carries inconvenience; Powder should not be used there being the dermatosis of sepage or purulent secretion; Ointment is oxidizable to become sour, and not easy cleaning; Liniment is without slow releasing function, and effect is difficult lasting.
Although illustrate and describe embodiments of the invention, those having ordinary skill in the art will appreciate that: do not departing under principle of the present invention and aim and can carry out multiple change, amendment, replacement and modification to these embodiments, scope of the present invention is by claim and equivalents thereof.
Claims (6)
1. a salicylic acid pulullan polysaccharide liniment, is characterized in that: represent with weight, salicylic acid 40 ~ 200g, pulullan polysaccharide 10 ~ 50g, POLYPROPYLENE GLYCOL 5 ~ 20g, ethylene glycol 83 ~ 125g, azone 5 ~ 10g, deionized water 200 ~ 600g, and ethanol 500 ~ 900g forms.
2. a kind of salicylic acid pulullan polysaccharide liniment according to claim 1, is characterized in that: represent with weight, described salicylic acid 100g, pulullan polysaccharide 20g, POLYPROPYLENE GLYCOL 15g, ethylene glycol 100g, azone 8g, upper deionized water 400g, ethanol 500g.
3. the preparation method of a kind of salicylic acid pulullan polysaccharide liniment according to claim 1, is characterized in that: comprise the following steps:
(1) take 20g pulullan polysaccharide and 15g POLYPROPYLENE GLYCOL adds in 400g deionized water, soak and heat, making it fully dissolve;
(2) add 100g ethylene glycol wherein again, make its mix homogeneously, obtain blank coating liquid, stand-by;
(3) take salicylic acid 100g to incorporate in 100g alcoholic solution, then add 8g azone, add in blank coating liquid after mixing, heated and stirred, to dissolving completely, obtains uniform white solution;
(4) white solution is placed in the temperature environment of 10 ~ 25 degrees Celsius, add alcoholic solution and be settled to 1000mL, obtain white salicylic acid pulullan polysaccharide liniment.
4. the preparation method of a kind of salicylic acid pulullan polysaccharide liniment according to claim 3, is characterized in that: the whipping process of described step (3) is completed by magnetic stirring apparatus.
5. the preparation method of a kind of salicylic acid pulullan polysaccharide liniment according to claim 3, is characterized in that: in described step (3) in heated and stirred process, add 100g ethanol while hot, make it dissolve more abundant.
6. the preparation method of a kind of salicylic acid pulullan polysaccharide liniment according to claim 3, is characterized in that: the container adding ethanol standardize solution in described step (4) is the beaker of 1500mL.
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| CN201510612015.8A CN105106181A (en) | 2015-09-23 | 2015-09-23 | Salicylic acid Pullulan coating agent and preparation method thereof |
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| CN201510612015.8A CN105106181A (en) | 2015-09-23 | 2015-09-23 | Salicylic acid Pullulan coating agent and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108174896A (en) * | 2018-02-06 | 2018-06-19 | 浦江县泰如食品科技有限公司 | A kind of ship biscuit preparation method full of nutrition |
| US11319566B2 (en) | 2017-04-14 | 2022-05-03 | Capsugel Belgium Nv | Process for making pullulan |
| US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006009987A2 (en) * | 2004-06-22 | 2006-01-26 | E-L Management Corp. | Dissolvable film composition |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006009987A2 (en) * | 2004-06-22 | 2006-01-26 | E-L Management Corp. | Dissolvable film composition |
Non-Patent Citations (1)
| Title |
|---|
| 李海鹰等: "水杨酸普鲁兰多糖涂膜剂的制备及安全性评价", 《河北大学学报(自然科学版)》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11319566B2 (en) | 2017-04-14 | 2022-05-03 | Capsugel Belgium Nv | Process for making pullulan |
| US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
| US11878079B2 (en) | 2017-04-14 | 2024-01-23 | Capsugel Belgium Nv | Pullulan capsules |
| CN108174896A (en) * | 2018-02-06 | 2018-06-19 | 浦江县泰如食品科技有限公司 | A kind of ship biscuit preparation method full of nutrition |
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