CN104815166B - A kind of Chinese medicine composition for treating diabetes and its preparation and application - Google Patents
A kind of Chinese medicine composition for treating diabetes and its preparation and application Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition, more particularly to a kind of Chinese medicine composition for treating diabetes and its preparation and application, belong to tcm field.The Chinese medicine composition of the treatment diabetes of the present invention, its raw material composition include dogwood fruit, ginseng fibrous root, the dried rhizome of rehmannia, sealwort, the Radix Astragali, the root of herbaceous peony, the fruit of Chinese wolfberry, the wind-weed, radix scrophulariae, the coptis, dark plum, guava bark, oyster, radix stellariae dichotomae, Radix picrorrhizae, the red sage root, Ramulus euonymi, aloe, giant knotweed.The Chinese medicine composition supplementing qi and nourishing yin of the present invention, clearing heat and promoting fluid.Hinder Tianjin and syndrome of deficiency of both qi and yin for type ii diabetes to be scorching, symptoms include it is thirsty drink, urine volume frequency is more, and rapid digestion of food and polyorexia, body is gradually thin, lassitude hypodynamia, and spontaneous sweating is dysphoria in chestpalms-soles, turbid urine, constipation etc..
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, more particularly to a kind of Chinese medicine composition for treating diabetes and its prepare and
Using belonging to tcm field.
Background technology
Diabetes (diabetes) are a kind of metabolic diseases characterized by hyperglycaemia, with hypertension, high fat of blood together
Referred to as " three high ", it is by inherent cause, immunologic function disorder, microorganism infection and its toxin, free radical toxin, mental element etc.
Various virulence factors act on sugar, protein, fat, the water that body causes hypoinsulinism, insulin resistance etc. and triggered
With a series of metabolic disorder syndromes such as electrolyte.Particularly a middle-aged person of " adult diabetes mellitus " more than 40 years old catches rate
It is especially high.Long-standing hyperglycaemia during diabetes, cause various tissues, particularly eye, kidney, heart, blood vessel, nerve it is chronic
Infringement, dysfunction.
Diabetes divide the diabetes of type i diabetes, type ii diabetes, gestational diabetes mellitus and other specific types.Generally close
Note and study and be more for type i diabetes and type ii diabetes：
1. I type patients with type Ⅰ DM is a kind of autoimmune disease.Autoimmune disease is due to the immune system of body to certainly
Body makes what attack formed.The immune system of diabetic makes attack to the pancreas beta cell of itself excreting insulin simultaneously
Them are killed, as a result pancreas can not secrete enough insulin.Because insulin secretion lacks, patient need to rely on exogenous pancreas islet
Element is supplemented to sustain life.
2. type ii diabetes are Adult Onset's patients with type Ⅰ DM, more in the sequela of 35-40 year, account for diabetic 90% with
On.The ability that patient's body produces insulin not completely loses, and some patient's body insulin even produces excessively, but pancreas islet
The action effect of element is but had a greatly reduced quality, therefore the insulin of patient's body is a kind of relative shortage.
Type ii diabetes have stronger heredity and environmental factor, and may occur in which in significant heterogeneity, its model case
Diuresis, more drink, eat more, become thin etc. and show, be i.e. " three-many-one-little " symptom, diabetes once control it is bad can trigger complication, lead
The exhaustion lesion at the positions such as kidney, eye, foot is caused, and can not be cured.
Nowadays, the most frequently used treatment means are cured the symptoms, not the disease to take the hypoglycemic medicines such as melbine, can only it is hypoglycemic and
Without ruling by law blood glucose, long-term use not only can bring burden to the body of patient, and be also easy to make patient body the resistance to the action of a drug occur.
TCM treatment of diabetes focuses on overall regulation and control, and doctor trained in Western medicine is substantially better than improving symptom etc..It is suitable for non-pancreas islet
Plain dependent diabetes (i.e. type ii diabetes), therefore the existing Chinese medicine composition for needing to research and develop treatment diabetes.
The content of the invention
The present invention is directed to the deficiency of existing diabetes treatment by western medicine, there is provided a kind of Chinese medicine composition for treating diabetes.
The technical scheme that the present invention solves above-mentioned technical problem is as follows：A kind of Chinese medicine composition for treating diabetes, it is former
Expect that composition and ratio are as follows：
The parts by weight of dogwood fruit 28~32；The parts by weight of ginseng fibrous root 36~42；The parts by weight of the dried rhizome of rehmannia 28~32；The weight of sealwort 28~32
Part；The parts by weight of the Radix Astragali 18~22；The parts by weight of the root of herbaceous peony 18~22；The parts by weight of the fruit of Chinese wolfberry 36~42；The parts by weight of the wind-weed 28~32；Radix scrophulariae
28~32 parts by weight；The parts by weight of the coptis 36~42；The parts by weight of dark plum 28~32；The parts by weight of guava bark 36~42；Oyster 28~
32 parts by weight；The parts by weight of radix stellariae dichotomae 18~22；The parts by weight of Radix picrorrhizae 28~32；The parts by weight of the red sage root 28~32；Ramulus euonymi 36~42
Parts by weight；The parts by weight of aloe 14~16；The parts by weight of giant knotweed 28~32.
Preferably, the raw material composition and ratio of the Chinese medicine composition for treating diabetes are as follows：The parts by weight of dogwood fruit 30；People
Ginseng must 40 parts by weight；The parts by weight of the dried rhizome of rehmannia 30；The parts by weight of sealwort 30；The parts by weight of the Radix Astragali 20；The parts by weight of the root of herbaceous peony 20；The weight of the fruit of Chinese wolfberry 40
Part；The parts by weight of the wind-weed 30；The parts by weight of radix scrophulariae 30；The parts by weight of the coptis 40；The parts by weight of dark plum 30；The parts by weight of guava bark 40；Oyster
30 parts by weight；The parts by weight of radix stellariae dichotomae 20；The parts by weight of Radix picrorrhizae 30；The parts by weight of the red sage root 30；The parts by weight of Ramulus euonymi 40；The weight of aloe 15
Part；The parts by weight of giant knotweed 30.
Further, capsule, granule, pill or soup is made by adding or not adding auxiliary material in the Chinese medicine composition
Agent.
The auxiliary material is various pharmaceutically conventional auxiliary materials and/or excipient, including but not limited to carbohydrate (such as lactose,
Dextrose and saccharose), starch (such as cornstarch and potato starch), cellulose and its derivates (such as sodium carboxymethylcellulose, second
Base cellulose and methylcellulose), tragacanth gum powder, malt, gelatin, talcum, kollag (such as stearic acid and stearic acid
Magnesium), calcium sulfate, vegetable oil, such as peanut oil, cottonseed oil, sesame oil, olive oil, corn oil and cupu oil, polyalcohol (such as the third two
Alcohol, glycerine, D-sorbite, mannitol and polyethylene glycol), alginic acid, emulsifying agent (such as Tween), wetting agent (such as lauryl sulphur
Sour sodium), colouring agent, flavor enhancement, tablet agent, stabilizer, antioxidant, preservative, apirogen water, isotonic salting liquid and phosphate
Buffer solution etc..Auxiliary material can improve stability, activity and biological effectiveness of formula etc. as needed, or be produced in the case of oral
Raw acceptable mouthfeel or smell.
In the Chinese medicine composition of the present invention, dogwood fruit tonifies the liver and kidney in side, astringent or styptic treatment for spontaneous sweating vital essence；Ginseng fibrous root is reinforced vital energy, and is promoted the production of body fluid
Quench the thirst；Dried rhizome of rehmannia replenishing the vital essence and removing heat, fluid dryness.Three medicine phases are matched somebody with somebody, and gather yin-nourishing QI invigorating, the effect of clearing heat and promoting fluid altogether, are altogether monarch drug in a prescription.Minister is with Huang
Essence, Radix Astragali nourshing kidney moistening lung, strengthening the spleen and replenishing qi；The root of herbaceous peony, matrimony vine tonifying liver kidney yin；The wind-weed, radix scrophulariae, the coptis let out that lung stomach is scorching clearly and enriching yin,
To increase the work(of monarch drug in a prescription.Dark plum is held back Yin and promoting production of body liquid and quenched the thirst；Guava bark, oyster convergence are astringent or styptic treatment for spontaneous sweating；Radix stellariae dichotomae, Radix picrorrhizae enter the moon and distinguish void
Heat；The red sage root, Ramulus euonymi promoting blood circulation；Aloe, giant knotweed relieving constipation by purgation, it is altogether adjutant.
Second aspect of the present invention discloses the preparation method of the Chinese medicine composition of aforementioned therapies diabetes, is decocting method, bag
Include following steps：
1) soak：According to the formula of Chinese medicine composition, raw material is put into 8~10 times of amount cold water and soaked 20~40 minutes；
2) decoct：The medicinal material big fire soaked is fried open, turns after small fire decocts 40~60 minutes, to be separated by filtration and obtain the dregs of a decoction and filter
Liquid；
3) secondary decoction：Add the water of 4~6 times of amounts again into the dregs of a decoction of previous step, big fire turns small fire and decocts 30 after being fried open
~40 minutes, filter to take filtrate；
4) combining step 2) and step 3) filtrate, low-temperature evaporation is concentrated into relative density as 1.05~1.15, in acquisition
The decoction of drug composition.
It is water extraction and alcohol precipitation method the invention also discloses the preparation method of the Chinese medicine composition of another treatment diabetes, bag
Include following steps：
1. decoct：According to the formula of Chinese medicine composition, the water of 8~10 times of amounts is added into raw material, it is small that heating decocts 1~2
When；After separation of solid and liquid, add the water of 4~6 times of amounts, heating decocts 1~1.5 hour, merges the filtrate decocted twice；
2. filtrate low-temperature evaporation is concentrated into relative density for 1.15~1.2, under stirring condition, 2 times of amounts are slowly added into
95%v/v ethanol solutions, stir 18~25 minutes, it is cold heavy 36~60 hours, supernatant is poured out, is filtered；
3. being distilled to recover ethanol, it is 1.25~1.35 to be further continued for being concentrated by evaporation to relative density, and placing 20~28 hours makes
Precipitation is complete, and filtration, filtrate is in low-temperature evaporation to paste；
4. auxiliary material is added into the thick paste of previous step is made softwood, mixes, particle is made, dry, obtain Chinese traditional medicine composition
The granule of thing.
Last aspect of the present invention discloses foregoing Chinese medicine composition and is preparing the application in treating type II diabetes medicine.
The beneficial effects of the invention are as follows：The Chinese medicine composition supplementing qi and nourishing yin of the present invention, clearing heat and promoting fluid.For type ii diabetes
Scorching to hinder Tianjin and syndrome of deficiency of both qi and yin, symptoms include thirsty more drinks, urine volume frequency is more, and rapid digestion of food and polyorexia, body is gradually thin, lassitude hypodynamia, and spontaneous perspiration is stolen
Sweat, dysphoria in chestpalms-soles, turbid urine, constipation etc..
Embodiment
The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit
Determine the scope of the present invention.
The preparation of the Chinese medicine composition decoction of embodiment 1
1. Traditional Chinese medicine composition formula
Dogwood fruit 30g, ginseng fibrous root 40g, dried rhizome of rehmannia 30g；Sealwort 30g, Radix Astragali 20g, root of herbaceous peony 20g, fruit of Chinese wolfberry 40g, the wind-weed
30g, radix scrophulariae 30g, coptis 40g；Dark plum 30g, guava bark 40g, oyster 30g, radix stellariae dichotomae 20g, Radix picrorrhizae 30g, red sage root 30g,
Ramulus euonymi 40g, aloe 15g, giant knotweed 30g.
2. preparation method
1) above-mentioned medicinal material is placed in steel steamer, is about 8 times of amounts of medicinal material with cool water quantity, soaks 30 minutes；
2) soaked medicinal material is fried open with high heat, turns warm fire and decoct 50 minutes, filter out decoction；
3) after filtering out decoction, 5 times of amount cold water are added again and are fried open, turns warm fire and decocts 40 minutes, filter out decoction；
4) by above-mentioned steps 2) merge with the decoction of step 3), mix, filter, filtrate low-temperature evaporation is concentrated into relative density
For 1.1 decoction.
The preparation of the traditional Chinese medicine particle of embodiment 2
1. Traditional Chinese medicine composition formula
Dogwood fruit 28g, ginseng fibrous root 42g, dried rhizome of rehmannia 28g；Sealwort 32g, Radix Astragali 22g, root of herbaceous peony 18g, fruit of Chinese wolfberry 36g, the wind-weed
32g, radix scrophulariae 28g, coptis 36g；Dark plum 28g, guava bark 42g, oyster 32g, radix stellariae dichotomae 18g, Radix picrorrhizae 28g, red sage root 28g,
Ramulus euonymi 42g, aloe 14g, giant knotweed 32g.
2. preparation method
1. by above-mentioned medicinal material, for the first time plus about 10 times of water measured of water, heating decoct 1.5 hours；Second plus about 4 times of amounts of water
Water, heating decoct 1.5 hours, merging filtrate, filtration.
2. it is 1.15 that filtrate low-temperature evaporation, which is concentrated into relative density, it is sufficiently stirred down, is slowly added into 95% second of 2 times of amounts
Alcohol, stir 20 minutes, it is cold heavy 48 hours, supernatant is poured out, is filtered.
3. being distilled to recover ethanol, it is 1.3 to be further continued for being concentrated by evaporation to relative density, and cold place is placed 24 hours, makes precipitation complete
Entirely, filter, filtrate is standby in low-temperature evaporation to paste.
4. thick paste is placed in container, adding dextrin, (dextrin is 1 with thick paste mass ratio：2) and volumetric concentration is 70%
Ethanol solution softwood is made, mix, particle is made, dry, produce Chinese medicinal composition granules.
The preparation of the Chinese medicinal composition capsules of embodiment 3
1. Traditional Chinese medicine composition formula
Dogwood fruit 32g, ginseng fibrous root 36g, dried rhizome of rehmannia 32g；Sealwort 28g, Radix Astragali 18g, root of herbaceous peony 22g, fruit of Chinese wolfberry 42g, the wind-weed
28g, radix scrophulariae 32g, coptis 42g；Dark plum 32g, guava bark 36g, oyster 28g, radix stellariae dichotomae 22g, Radix picrorrhizae 32g, red sage root 32g,
Ramulus euonymi 36g, aloe 16g, giant knotweed 28g.
2. preparation method
1. by above-mentioned medicinal material drying, mix, smash into fine powder, No. six sieves all should be passed through.
2. by above-mentioned medicinal powder, No. 1 capsule, each 0.5 gram of weight are loaded under drying regime.
The animal experiment of the traditional Chinese medicine composition for treating diabetes of embodiment 4
1. the structure of animal model of diabetes mellitus type II
The healthy 7 week old male SD rats of selection give high fat diet (high-sugar-fat-diet formula used by high fat diet
For：Lard 15%, sucrose 20%, cholesterol 5%, common mouse feed 60%, is weight/mass percentage composition) after 8 weeks, intraperitoneal injection
Streptozotocin (0.5% Streptozotocin 30mg/kg, 0.1mmol/L citrate buffer solution, pH4.4), after injecting 7d, success
Prepare type II diabetes rat 50.
2. experimental method and result
Blank control group is used as using untreated 10 SD rats；Successfully construct 50 type II diabetes rats are random
Selection 10 is only used as model control group, and remaining rat model stochastic averagina is divided into two groups, respectively Chinese medicine composition group (this hair
Bright Chinese medicine composition), and glibenclamide group (Glibenclamide Tablets, purchased from the ability Pharmaceutical Group Co., Ltd of Guangdong three).Chinese medicine group is every
Day gastric infusion 1 time (Chinese medicine composition decoction 10ml/kg prepared by embodiment 1), the daily medication of glibenclamide group (7.8mg/kg),
Model control group and blank control group such as give at the physiological saline (giving 1mL per 100g) of capacity, the continuous use 30d respectively.Point
The 15th day not after medicine, 30 days, fasting 12h, blood glucose is surveyed 1 time, the results are shown in Table 1.
Influence of the Chinese medicine composition of table 1 to mouse blood sugar
Compared with model control group, * P ＜ 0.05, * * P ＜ 0.01.
From upper table 1, Chinese medicine composition of the invention can significantly reduce Streptozotocin and lure compared with model control group
Treating diabetes are had remarkable result by the blood glucose of the type II diabetes rat of hair.
The effect of the Chinese medicine composition clinical treatment diabetes of embodiment 5
1. case selection：
Case is selected by WHO diabetes diagnostic criterions, is II diabetics, and meet《New Chinese medicine treatment is quenched one's thirst
The guideline of clinical investigations of sick (diabetes)》The middle dialectical standard of deficiency of both qi and yin disease.
Accept Patients with 300 Cases for medical treatment altogether, be randomly divided into treatment group and control group：Treatment group 120, wherein man 60, female 60,
Age at 38~65 years old, the course of disease 3~15 years；Severity extent：Slight 23, moderate 64, severe 33.Control group 120, its
Middle male 63, female 57,38~65 years old age, the course of disease 3~15 years；Severity extent：Slight 24, moderate 68, severe 28.
2. treatment method：
Two groups are kept on a diet on request.The Chinese medicine composition decoction 200-250ml of the oral embodiment 1 for the treatment of group, daily 2
It is secondary, in, 30min is drunk before dinner；The oral diabetes pill of control group (Guangzhou Zhongyi Medicine Industry Co., Ltd), 8 tablets each time, 3 times a day,
The early, middle and late warm waters of 30min before the meal clothes are sent.Two groups of drug treatments are 60 days.
3. clinical development standard
Formulated with reference to the Ministry of Public Health《The guideline of clinical investigations of new Chinese medicine treatment diabete (diabetes)》Middle curative effect
Criterion.
4. treatment results：
The result of therapeutic effect see the table below 2.
The traditional Chinese medicine composition for treating effect of table 2
| Group | Total number of cases | It is effective | Effectively | It is invalid | Total effective rate |
| Treatment group | 120 | 40 | 60 | 20 | 83.3% |
| Control group | 120 | 44 | 61 | 15 | 87.5% |
It can be seen that the effect of effect of Chinese medicine composition of the present invention is close to existing Remedies for diabetes.It is thirsty more to improving
The clinical total effective rate such as drink, rapid digestion of food and polyorexia, diuresis, lassitude hypodynamia, spontaneous sweating, dysphoria in chestpalms-soles, turbid urine, constipation, treatment group
Better than control group, the effect of disclosing the capsule of the Chinese medicine composition, is better than control group.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.
Claims (6)
1. a kind of Chinese medicine composition for treating diabetes, its raw material composition and ratio is as follows：The parts by weight of dogwood fruit 28~32；Ginseng
Must 36~42 parts by weight；The parts by weight of the dried rhizome of rehmannia 28~32；The parts by weight of sealwort 28~32；The parts by weight of the Radix Astragali 18~22；The root of herbaceous peony 18~22
Parts by weight；The parts by weight of the fruit of Chinese wolfberry 36~42；The parts by weight of the wind-weed 28~32；The parts by weight of radix scrophulariae 28~32；The parts by weight of the coptis 36~42；
The parts by weight of dark plum 28~32；The parts by weight of guava bark 36~42；The parts by weight of oyster 28~32；The parts by weight of radix stellariae dichotomae 18~22；Recklessly
The parts by weight of the coptis 28~32；The parts by weight of the red sage root 28~32；The parts by weight of Ramulus euonymi 36~42；The parts by weight of aloe 14~16；Giant knotweed 28
~32 parts by weight.
2. Chinese medicine composition according to claim 1, it is characterised in that the raw material composition and ratio of the Chinese medicine composition
It is as follows：The parts by weight of dogwood fruit 30；The parts by weight of ginseng fibrous root 40；The parts by weight of the dried rhizome of rehmannia 30；The parts by weight of sealwort 30；The parts by weight of the Radix Astragali 20；In vain
The parts by weight of Chinese herbaceous peony 20；The parts by weight of the fruit of Chinese wolfberry 40；The parts by weight of the wind-weed 30；The parts by weight of radix scrophulariae 30；The parts by weight of the coptis 40；The weight of dark plum 30
Part；The parts by weight of guava bark 40；The parts by weight of oyster 30；The parts by weight of radix stellariae dichotomae 20；The parts by weight of Radix picrorrhizae 30；The parts by weight of the red sage root 30；
The parts by weight of Ramulus euonymi 40；The parts by weight of aloe 15；The parts by weight of giant knotweed 30.
3. Chinese medicine composition according to claim 1 or 2, it is characterised in that the Chinese medicine composition is by addition or not
Capsule, granule, pill or decoction is made in addition auxiliary material.
It is decocting method 4. treating the preparation method of the Chinese medicine composition of diabetes described in claim 1-3 any claims, bag
Include following steps：
1) soak：According to the formula of Chinese medicine composition, raw material is put into 8~10 times of amount cold water and soaked 20~40 minutes；
2) decoct：The medicinal material big fire soaked is fried open, turns after small fire decocts 40~60 minutes, to be separated by filtration and obtain the dregs of a decoction and filtrate；
3) secondary decoction：Add the water of 4~6 times of amounts again into the dregs of a decoction of previous step, big fire turns small fire and decocts 30~40 after being fried open
Minute, filter to take filtrate；
4) combining step 2) and step 3) filtrate, low-temperature evaporation is concentrated into relative density as 1.05~1.15, obtains Chinese medicine group
The decoction of compound.
It is water extract-alcohol precipitation 5. treating the preparation method of the Chinese medicine composition of diabetes described in claim 1-3 any claims
Method, comprise the following steps：
1. decoct：According to the formula of Chinese medicine composition, the water of 8~10 times of amounts is added into raw material, heats and decocts 1~2 hour；Gu
After liquid separation, add the water of 4~6 times of amounts, heating decocts 1~1.5 hour, merges the filtrate decocted twice；
2. it is 1.15~1.2 that filtrate low-temperature evaporation is concentrated into relative density, under stirring condition, the 95% of 2 times of amounts is slowly added into
V/v ethanol solutions, stir 18~25 minutes, it is cold heavy 36~60 hours, supernatant is poured out, is filtered；
3. being distilled to recover ethanol, it is 1.25~1.35 to be further continued for being concentrated by evaporation to relative density, and placing 20~28 hours makes precipitation
Completely, filter, filtrate is in low-temperature evaporation to paste；
4. auxiliary material is added into the thick paste of previous step is made softwood, mixes, particle is made, dry, obtain Chinese medicine composition
Granule.
6. Chinese medicine composition described in claim 1-3 any claims is preparing the application in treating type II diabetes medicine.
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| CN108578605A (en) * | 2018-07-18 | 2018-09-28 | 合肥华盖生物科技有限公司 | A kind of Chinese medicine composition for treating diabetes |
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| CN1879783A (en) * | 2006-05-18 | 2006-12-20 | 张将勇 | A medicine for treating diabetes |
| CN102274447A (en) * | 2011-08-27 | 2011-12-14 | 赵国辉 | Medicinal composition for treating diabetes |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1879783A (en) * | 2006-05-18 | 2006-12-20 | 张将勇 | A medicine for treating diabetes |
| CN102274447A (en) * | 2011-08-27 | 2011-12-14 | 赵国辉 | Medicinal composition for treating diabetes |
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| Title |
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| 补肾阳法治疗糖尿病;徐丹慧等;《河南中医》;19981020(第05期);314- * |
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