CN108578605A - A kind of Chinese medicine composition for treating diabetes - Google Patents

A kind of Chinese medicine composition for treating diabetes Download PDF

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Publication number
CN108578605A
CN108578605A CN201810790514.XA CN201810790514A CN108578605A CN 108578605 A CN108578605 A CN 108578605A CN 201810790514 A CN201810790514 A CN 201810790514A CN 108578605 A CN108578605 A CN 108578605A
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parts
chinese medicine
medicine composition
radix
treatment
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张安育
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Hefei Huagai Biotechnology Co Ltd
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Hefei Huagai Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/808—Scrophularia (figwort)
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/80—Scrophulariaceae (Figwort family)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The present invention relates to a kind of Chinese medicine composition more particularly to a kind of Chinese medicine compositions for treating diabetes, are made of following raw material：Radix scrophulariae, sealwort, Radix Paeoniae Alba, Radix Rehmanniae, Poria cocos, the fleece-flower root, the membrane of a chicken's gizzard, rhizoma anemarrhenae, coix seed, stringy stonecrop, rhizoma alismatis, Schisandra chinensis, Radix Salviae Miltiorrhizae, Fructus Corni, the coptis, Radix Notoginseng, glutinous rehmannia, Rabdosia rubescens, matrimony vine.The present invention utilizes the compatibility between each component of Chinese medicine; make it possible to effectively activate inertia insulin; reduce blood glucose; make inertia insulin activity recovery; it is normal to participate in glycometabolism; improve utilization and conversion capability of the human body itself to blood glucose; reaching balance reduces blood glucose, can protect islet cells, inhibits insulin failure; in the case where the insulin that may participate in glycometabolism increases; pancreas islet need not hypersecretion as before insulin, pancreas burden mitigates, and obtains necessary rest and reorganization; and then play the role of protection pancreas islet, inhibit islet failure.

Description

A kind of Chinese medicine composition for treating diabetes
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine composition for treating diabetes.
Background technology
Diabetes are a kind of with sugar, fat, protein etc. caused by internal hypoinsulinism or effect defect Metabolic disorder is the common endocrine metabolism disease of main feature.In recent years, with the improvement of people ' s living standards, life side The factors such as the change of formula, the incidence rapid development of global diabetes, diabetes have become after tumour, cardiovascular pathological changes The third-largest common disease for seriously threatening human health and life later.The clinical manifestation of diabetes belongs to quenching one's thirst for traditional Chinese medicine Scope, to eat, mostly drink, diuresis, weight loss etc. are common sympton more, and with the extension of the course of disease, patient gradually feels soft Weak inability, weight is substantially reduced, each system damage then occurs（Angiocarpy, the cerebrovascular, nerve, kidney, eye etc.）A series of evenings The chronic complicating diseases such as phase clinical manifestation, i.e. complicated with diabetes nephrosis, diabetic cardiovascular disease change, diabetic neuropathy, at For death the main reason for.
Treatment diabetes mostly use western medicine at present, mainly there is insulin secretion stimulators, ɑ-Glucosidase inhibitor Agent, growth factor antagonist, angiotensin converting enzyme inhibitor etc., such as insulin, biguanides, sulfonylurea, but Western medicine With certain limitation and larger side effect, long-term use is not only larger to liver, injury of kidney, but also easy tos produce drug resistance Property, it is difficult to fundamentally treat diabetes, cause the satisfaction rate of patient and its family members low.Therefore, actively find a kind of effect it is good, The Chinese medicine of the treatment diabetes of few side effects is the emphasis place of research.
Invention content
In view of the above-mentioned analysis to the prior art, the present invention provides a kind of Chinese medicine composition for treating diabetes, treatment effect Fruit significantly and Small side effects.
In order to achieve the above object, the present invention is achieved through the following technical solutions：
The raw material composition and ratio of a kind of Chinese medicine composition for treating diabetes, the Chinese medicine composition are as follows：Radix scrophulariae 10-30 Part, 30-60 parts of sealwort, 15-30 parts of Radix Paeoniae Alba, 15-30 parts of Radix Rehmanniae, 15-30 parts of Poria cocos, 10-30 parts of the fleece-flower root, the membrane of a chicken's gizzard 10-20 Part, 10-15 parts of rhizoma anemarrhenae, 10-20 parts of coix seed, 10-20 parts of stringy stonecrop, 10-15 parts of rhizoma alismatis, 6-15 parts of Schisandra chinensis, Radix Salviae Miltiorrhizae 15-40 Part, 10-20 parts of Fructus Corni, 15-30 parts of the coptis, 10-20 parts of Radix Notoginseng, 15-60 parts of glutinous rehmannia, 10-30 parts of giant knotweed, Rabdosia rubescens 10-30 Part, 10-15 parts of matrimony vine.
Preferably, the raw material composition and ratio of the Chinese medicine composition are as follows：15-25 parts of radix scrophulariae, sealwort 40-50 Part, 19-26 parts of Radix Paeoniae Alba, 19-26 parts of Radix Rehmanniae, 19-26 parts of Poria cocos, 15-25 parts of the fleece-flower root, 13-17 parts of the membrane of a chicken's gizzard, rhizoma anemarrhenae 11-13 Part, 12-17 parts of coix seed, 13-17 parts of stringy stonecrop, 11-14 parts of rhizoma alismatis, 8-12 parts of Schisandra chinensis, 23-32 parts of Radix Salviae Miltiorrhizae, Fructus Corni 13- 17 parts, 19-26 parts of the coptis, 12-17 parts of Radix Notoginseng, 30-45 parts of glutinous rehmannia, 15-25 parts of giant knotweed, 15-25 parts of Rabdosia rubescens, matrimony vine 12-14 Part.
Preferably, the raw material composition and ratio of the Chinese medicine composition are as follows：It is 20 parts of radix scrophulariae, 45 parts of sealwort, white 23 parts of Chinese herbaceous peony, 23 parts of Radix Rehmanniae, 23 parts of Poria cocos, 20 parts of the fleece-flower root, 15 parts of the membrane of a chicken's gizzard, 12 parts of rhizoma anemarrhenae, 15 parts of coix seed, stringy stonecrop 15 Part, 12 parts of rhizoma alismatis, 11 parts of Schisandra chinensis, 28 parts of Radix Salviae Miltiorrhizae, 15 parts of Fructus Corni, 23 parts of the coptis, 15 parts of Radix Notoginseng, 38 parts of glutinous rehmannia, Rabdosia rubescens 20 parts, 20 parts of matrimony vine.
Preferably, decoction, granule, tablet, pill, capsule is made by adding auxiliary material in the Chinese medicine composition Agent and pill.
Preferably, the auxiliary material be dextrin, lactose, starch, sucrose, glucose, microcrystalline cellulose, mannose, The one or more of methylcellulose, carboxy-propyl cellulose, carboxymethyl cellulose and stevioside.
Preferably, the present invention also provides the preparation methods of the Chinese medicine composition of above-mentioned treatment diabetes, it is wrapped Include following steps：
（1）Bulk pharmaceutical chemicals are weighed according to the ratio, are put it into marmite, the dipped powder 2-4cm of clear water are added, and impregnate 10-20min；
（2）First the bulk pharmaceutical chemicals being immersed in marmite clear water are boiled with high heat, are changed to be cooked by slow fire 20-30min later, then Decocting liquid is filtered to take, it is spare；
（3）It will be in step（2）Remaining filter residue is filtered successively according to step（1）And step（2）Operating method, carry out again Processing, filters to take decocting liquid, spare；
（4）By step（2）And step（3）It is 1.20-1.30 that the decocting liquid mixing of middle acquisition, which is concentrated into close DEG C relatively, is slowly added into 2 The 90%v/v ethanol solutions of amount again stir, and stand, filtering, and filtrate low-temperature evaporation is concentrated into close DEG C relatively as 1.40-1.50, and Ethyl alcohol is recycled, concentrate is obtained；
（5）Concentrate plus water and auxiliaries are spray-dried at decoction, or by concentrate, capsule, piece is made in addition auxiliary material Agent, pill, granule.
Preferably, step（4）In, the mixing time is 18-25 minutes.
Preferably, step（4）In, the time of repose is 35-55 hours.
Preferably, step（4）In, spray drying condition is：It it is 100-120 DEG C into wind-warm syndrome DEG C, outlet temperature DEG C is 80-90 DEG C, material temperature DEG C is 70-90 DEG C, atomizing pressure 0.2-0.4MPa, and spraying speed DEG C is 5-10ml/s.
Preferably, step（5）In, spray drying condition is：It is 110 DEG C into wind-warm syndrome DEG C, outlet temperature DEG C is 85 DEG C, Material temperature DEG C is 80 DEG C, atomizing pressure 0.3MPa, and spraying speed DEG C is 7.5ml/s.
The present invention compared with prior art, with following advantageous effect：
（1）The formula of the present invention is according to China's theory of TCM, in conjunction with the clinical research of inventor for many years, traditional Chinese medicine The Empirical formula obtained in the refined diagnosis Technology application of macroscopical dialectical treatmert and modern medicine to clinical experimental study.In Medical knowledge opinion carries out dialectical compatibility component, bases oneself upon " asthenic symptoms " for the pathogenesis of diabetes, and qi-restoratives consolidates, simultaneous to reach sample The purpose controlled.Using radix scrophulariae, sealwort, Radix Paeoniae Alba and Radix Rehmanniae as major ingredient, it is aided with traditional Chinese medicine prescription formula, supports mutually, use is a variety of The combination of Chinese traditional herbs and medicinal and edible plant, is rich in various plants saponin(e, and Protein microassay element is supported with QI invigorating The moon, replenishing body fluid and clearing away heat pathogen, kidney tonifying, effect promoting blood circulation and removing blood stasis can improve body immunity, coordinate viscera function, fundamentally improve The physiological function of diabetes patient restores beta Cell of islet normal function, achievees the effect that treating both manifestation and root cause of disease, eliminate diabetes patient's deficiency syndrome of the lung, Spleen deficiency, deficiency of the kidney treat diabetes and complication.
（2）The present invention utilizes the compatibility between each component of Chinese medicine, enabling effectively activation inertia insulin reduces blood Sugar so that inertia insulin activity recovery normally participates in glycometabolism, improves human body itself to the utilization of blood glucose and conversion energy Power, reaching balance reduces blood glucose, can protect islet cells, inhibits insulin failure, increases in the insulin that may participate in glycometabolism In the case of more, pancreas islet need not hypersecretion as before insulin, pancreas burden mitigates, and obtains necessary rest and reorganization, into And play the role of protection pancreas islet, inhibit islet failure.
Specific implementation mode
By the following examples form, the above of the present invention is described in further detail but should not be by this again The range for being interpreted as the above-mentioned theme of the present invention is only limitted to following embodiment, is all based on the technology realized belonging to the above of the present invention It all belongs to the scope of the present invention.
Embodiment 1
The raw material composition and ratio of the Chinese medicine composition of the treatment diabetes of the present embodiment, the Chinese medicine composition are as follows：Radix scrophulariae 10 parts, 30 parts of sealwort, 15 parts of Radix Paeoniae Alba, 15 parts of Radix Rehmanniae, 15 parts of Poria cocos, 10 parts of the fleece-flower root, 10 parts of the membrane of a chicken's gizzard, 10 parts of rhizoma anemarrhenae, Job's tears 10 parts of benevolence, 10 parts of stringy stonecrop, 10 parts of rhizoma alismatis, 6 parts of Schisandra chinensis, 15 parts of Radix Salviae Miltiorrhizae, 10 parts of Fructus Corni, 15 parts of the coptis, 10 parts of Radix Notoginseng, 15 parts yellow, 10 parts of giant knotweed, 10 parts of Rabdosia rubescens, 10 parts of matrimony vine.
Wherein, decoction, granule, tablet, pill, capsule and dripping pill is made by adding auxiliary material in the Chinese medicine composition Agent.
Wherein, the auxiliary material is dextrin, lactose, starch, sucrose, glucose, microcrystalline cellulose, mannose, Methyl cellulose The one or more of element, carboxy-propyl cellulose, carboxymethyl cellulose and stevioside.
The present invention also provides the preparation methods of the Chinese medicine composition of above-mentioned treatment diabetes, it includes the following steps：
（1）Bulk pharmaceutical chemicals are weighed according to the ratio, are put it into marmite, the dipped powder 2cm of clear water are added, and impregnate 10min；
（2）First the bulk pharmaceutical chemicals being immersed in marmite clear water are boiled with high heat, are changed to be cooked by slow fire 20min later, after Leaching decocting liquid, it is spare；
（3）It will be in step（2）Remaining filter residue is filtered successively according to step（1）And step（2）Operating method, carry out again Processing, filters to take decocting liquid, spare；
（4）By step（2）And step（3）Middle acquisition decocting liquid mixing be concentrated into close DEG C relatively be 1.20, be slowly added into 2 times amount 90%v/v ethanol solutions stir, and stand, filtering, and it is 1.40 that filtrate low-temperature evaporation, which is concentrated into close DEG C relatively, and recycles ethyl alcohol, is obtained To concentrate；
（5）Concentrate plus water and auxiliaries are spray-dried at decoction, or by concentrate, capsule, piece is made in addition auxiliary material Agent, pill, granule.
Wherein, step（4）In, the mixing time is 18 minutes.
Wherein, step（4）In, the time of repose is 35 hours.
Wherein, step（5）In, spray drying condition is：It it is 100 DEG C into wind-warm syndrome DEG C, outlet temperature DEG C is 80 DEG C, material temperature DEG C It it is 70 DEG C, atomizing pressure 0.2MPa, spraying speed DEG C is 5ml/s
Embodiment 2
The raw material composition and ratio of the Chinese medicine composition of the treatment diabetes of the present embodiment, the Chinese medicine composition are as follows：Radix scrophulariae 30 parts, 60 parts of sealwort, 30 parts of Radix Paeoniae Alba, 30 parts of Radix Rehmanniae, 30 parts of Poria cocos, 30 parts of the fleece-flower root, 20 parts of the membrane of a chicken's gizzard, 15 parts of rhizoma anemarrhenae, Job's tears 20 parts of benevolence, 20 parts of stringy stonecrop, 15 parts of rhizoma alismatis, 15 parts of Schisandra chinensis, 40 parts of Radix Salviae Miltiorrhizae, 20 parts of Fructus Corni, 30 parts of the coptis, 20 parts of Radix Notoginseng, 60 parts of glutinous rehmannia, 30 parts of giant knotweed, 30 parts of Rabdosia rubescens, 30 parts of matrimony vine.
Wherein, decoction, granule, tablet, pill, capsule and dripping pill is made by adding auxiliary material in the Chinese medicine composition Agent.
Wherein, the auxiliary material is dextrin, lactose, starch, sucrose, glucose, microcrystalline cellulose, mannose, Methyl cellulose The one or more of element, carboxy-propyl cellulose, carboxymethyl cellulose and stevioside.
The present invention also provides the preparation methods of the Chinese medicine composition of above-mentioned treatment diabetes, it includes the following steps：
（1）Bulk pharmaceutical chemicals are weighed according to the ratio, are put it into marmite, the dipped powder 2-4cm of clear water are added, and impregnate 20min；
（2）First the bulk pharmaceutical chemicals being immersed in marmite clear water are boiled with high heat, are changed to be cooked by slow fire 30min later, after Leaching decocting liquid, it is spare；
（3）It will be in step（2）Remaining filter residue is filtered successively according to step（1）And step（2）Operating method, carry out again Processing, filters to take decocting liquid, spare；
（4）By step（2）And step（3）Middle acquisition decocting liquid mixing be concentrated into close DEG C relatively be 1.30, be slowly added into 2 times amount 90%v/v ethanol solutions stir, and stand, filtering, and it is 1.50 that filtrate low-temperature evaporation, which is concentrated into close DEG C relatively, and recycles ethyl alcohol, is obtained To concentrate；
（5）Concentrate plus water and auxiliaries are spray-dried at decoction, or by concentrate, capsule, piece is made in addition auxiliary material Agent, pill, granule.
Wherein, step（4）In, the mixing time is 25 minutes.
Wherein, step（4）In, the time of repose is 55 hours.
Wherein, step（5）In, spray drying condition is：It it is 120 DEG C into wind-warm syndrome DEG C, outlet temperature DEG C is 90 DEG C, material temperature DEG C It it is 90 DEG C, atomizing pressure 0.4MPa, spraying speed DEG C is 10ml/s.
Embodiment 3
The raw material composition and ratio of the Chinese medicine composition of the treatment diabetes of the present embodiment, the Chinese medicine composition are as follows：Radix scrophulariae 20 parts, 45 parts of sealwort, 23 parts of Radix Paeoniae Alba, 23 parts of Radix Rehmanniae, 23 parts of Poria cocos, 20 parts of the fleece-flower root, 15 parts of the membrane of a chicken's gizzard, 12 parts of rhizoma anemarrhenae, Job's tears 15 parts of benevolence, 15 parts of stringy stonecrop, 12 parts of rhizoma alismatis, 11 parts of Schisandra chinensis, 28 parts of Radix Salviae Miltiorrhizae, 15 parts of Fructus Corni, 23 parts of the coptis, 15 parts of Radix Notoginseng, 38 parts of glutinous rehmannia, 20 parts of giant knotweed, 20 parts of Rabdosia rubescens, 20 parts of matrimony vine.
Wherein, decoction, granule, tablet, pill, capsule and dripping pill is made by adding auxiliary material in the Chinese medicine composition Agent.
Wherein, the auxiliary material is dextrin, lactose, starch, sucrose, glucose, microcrystalline cellulose, mannose, Methyl cellulose The one or more of element, carboxy-propyl cellulose, carboxymethyl cellulose and stevioside.
The present invention also provides the preparation methods of the Chinese medicine composition of above-mentioned treatment diabetes, it includes the following steps：
（1）Bulk pharmaceutical chemicals are weighed according to the ratio, are put it into marmite, the dipped powder 3cm of clear water are added, and impregnate 10-20min；
（2）First the bulk pharmaceutical chemicals being immersed in marmite clear water are boiled with high heat, are changed to be cooked by slow fire 25min later, after Leaching decocting liquid, it is spare；
（3）It will be in step（2）Remaining filter residue is filtered successively according to step（1）And step（2）Operating method, carry out again Processing, filters to take decocting liquid, spare；
（4）By step（2）And step（3）Middle acquisition decocting liquid mixing be concentrated into close DEG C relatively be 1.25, be slowly added into 2 times amount 90%v/v ethanol solutions stir, and stand, filtering, and it is 1.45 that filtrate low-temperature evaporation, which is concentrated into close DEG C relatively, and recycles ethyl alcohol, is obtained To concentrate；
（5）Concentrate plus water and auxiliaries are spray-dried at decoction, or by concentrate, capsule, piece is made in addition auxiliary material Agent, pill, granule.
Wherein, step（4）In, the mixing time is 21 minutes.
Wherein, step（4）In, the time of repose is 40 hours.
Wherein, step（5）In, spray drying condition is：It it is 110 DEG C into wind-warm syndrome DEG C, outlet temperature DEG C is 85 DEG C, material temperature DEG C It it is 80 DEG C, atomizing pressure 0.3MPa, spraying speed DEG C is 7.5ml/s.
Embodiment 4
The raw material composition and ratio of the Chinese medicine composition of the treatment diabetes of the present embodiment, the Chinese medicine composition are as follows：Radix scrophulariae 15 parts, 50 parts of sealwort, 20 parts of Radix Paeoniae Alba, 25 parts of Radix Rehmanniae, 30 parts of Poria cocos, 15 parts of the fleece-flower root, 10 parts of the membrane of a chicken's gizzard, 15 parts of rhizoma anemarrhenae, Job's tears 10 parts of benevolence, 18 parts of stringy stonecrop, 10 parts of rhizoma alismatis, 8 parts of Schisandra chinensis, 35 parts of Radix Salviae Miltiorrhizae, 10 parts of Fructus Corni, 30 parts of the coptis, 10 parts of Radix Notoginseng, 15 parts yellow, 15 parts of giant knotweed, 30 parts of Rabdosia rubescens, 20 parts of matrimony vine.
Wherein, decoction, granule, tablet, pill, capsule and dripping pill is made by adding auxiliary material in the Chinese medicine composition Agent.
Wherein, the auxiliary material is dextrin, lactose, starch, sucrose, glucose, microcrystalline cellulose, mannose, Methyl cellulose The one or more of element, carboxy-propyl cellulose, carboxymethyl cellulose and stevioside.
The present invention also provides the preparation methods of the Chinese medicine composition of above-mentioned treatment diabetes, it includes the following steps：
（1）Bulk pharmaceutical chemicals are weighed according to the ratio, are put it into marmite, the dipped powder 2.5cm of clear water are added, and impregnate 18min；
（2）First the bulk pharmaceutical chemicals being immersed in marmite clear water are boiled with high heat, are changed to be cooked by slow fire 23min later, after Leaching decocting liquid, it is spare；
（3）It will be in step（2）Remaining filter residue is filtered successively according to step（1）And step（2）Operating method, carry out again Processing, filters to take decocting liquid, spare；
（4）By step（2）And step（3）Middle acquisition decocting liquid mixing be concentrated into close DEG C relatively be 1.20, be slowly added into 2 times amount 90%v/v ethanol solutions stir, and stand, filtering, and it is 1.50 that filtrate low-temperature evaporation, which is concentrated into close DEG C relatively, and recycles ethyl alcohol, is obtained To concentrate；
（5）Concentrate plus water and auxiliaries are spray-dried at decoction, or by concentrate, capsule, piece is made in addition auxiliary material Agent, pill, granule.
Wherein, step（4）In, the mixing time is 22 minutes
Wherein, step（4）In, the time of repose is 40 hours.
Wherein, step（5）In, spray drying condition is：It it is 115 DEG C into wind-warm syndrome DEG C, outlet temperature DEG C is 90 DEG C, material temperature DEG C It it is 85 DEG C, atomizing pressure 0.4MPa, spraying speed DEG C is 8ml/s.
Embodiment 5
The raw material composition and ratio of the Chinese medicine composition of the treatment diabetes of the present embodiment, the Chinese medicine composition are as follows：Radix scrophulariae 15 parts, 30 parts of sealwort, 20 parts of Radix Paeoniae Alba, 30 parts of Radix Rehmanniae, 15 parts of Poria cocos, 10 parts of the fleece-flower root, 10 parts of the membrane of a chicken's gizzard, 15 parts of rhizoma anemarrhenae, Job's tears 20 parts of benevolence, 15 parts of stringy stonecrop, 15 parts of rhizoma alismatis, 15 parts of Schisandra chinensis, 15 parts of Radix Salviae Miltiorrhizae, 20 parts of Fructus Corni, 20 parts of the coptis, 20 parts of Radix Notoginseng, 20 parts of glutinous rehmannia, 25 parts of giant knotweed, 15 parts of Rabdosia rubescens, 10 parts of matrimony vine.
Wherein, decoction, granule, tablet, pill, capsule and dripping pill is made by adding auxiliary material in the Chinese medicine composition Agent.
Wherein, the auxiliary material is dextrin, lactose, starch, sucrose, glucose, microcrystalline cellulose, mannose, Methyl cellulose The one or more of element, carboxy-propyl cellulose, carboxymethyl cellulose and stevioside.
The present invention also provides the preparation methods of the Chinese medicine composition of above-mentioned treatment diabetes, it includes the following steps：
（1）Bulk pharmaceutical chemicals are weighed according to the ratio, are put it into marmite, the dipped powder 3.5cm of clear water are added, and impregnate 10min；
（2）First the bulk pharmaceutical chemicals being immersed in marmite clear water are boiled with high heat, are changed to be cooked by slow fire 20min later, after Leaching decocting liquid, it is spare；
（3）It will be in step（2）Remaining filter residue is filtered successively according to step（1）And step（2）Operating method, carry out again Processing, filters to take decocting liquid, spare；
（4）By step（2）And step（3）Middle acquisition decocting liquid mixing be concentrated into close DEG C relatively be 1.25, be slowly added into 2 times amount 90%v/v ethanol solutions stir, and stand, filtering, and it is 1.40 that filtrate low-temperature evaporation, which is concentrated into close DEG C relatively, and recycles ethyl alcohol, is obtained To concentrate；
（5）Concentrate plus water and auxiliaries are spray-dried at decoction, or by concentrate, capsule, piece is made in addition auxiliary material Agent, pill, granule.
Wherein, step（4）In, the mixing time is 20 minutes.
Wherein, step（4）In, the time of repose is 55 hours.
Wherein, step（5）In, spray drying condition is：It it is 115 DEG C into wind-warm syndrome DEG C, outlet temperature DEG C is 80 DEG C, material temperature DEG C It it is 85 DEG C, atomizing pressure 0.2MPa, spraying speed DEG C is 5ml/s.
Test example 1
The animal experiment of traditional Chinese medicine composition for treating diabetes
1, the structure of diabetes animal model
Select healthy 7 week old male SD rats give high fat diet (high-sugar-fat-diet formula used by high fat diet for： Lard 15%, sucrose 20%, cholesterol 5%, common mouse feed 60% are mass percentage) after 8 weeks, chain is injected intraperitoneally Urea helps rhzomorph (0.5% streptozotocin 30mg/kg, 0.1mmol/L citrate buffer solution, pH4.4), after injecting 7d, successfully makes Standby diabetes rat 50.
2, experimental method and result
Using untreated 10 SD rats as blank control group；Successful 50 diabetes rats will be built and randomly choose 10 As model control group, remaining rat model stochastic averagina is divided into two groups, respectively Chinese medicine composition group (Chinese medicine of the invention Composition) and glibenclamide group (Glibenclamide Tablets are purchased from three ability Pharmaceutical Group Co., Ltd of Guangdong).The daily gavage of Chinese medicine group is given Medicine 1 time (Chinese medicine composition 10ml/kg prepared by embodiment 1), the daily medication of glibenclamide group (7.8mg/kg), model control group Give the physiological saline (giving 1mL per 100g) of equal capacity, continuous use 30d respectively with blank control group.After medicine It 15 days, 30 days, fasting 12h, surveys blood glucose 1 time, the results are shown in Table 1
Influence of the pharmaceutical composition to mouse blood sugar in table 1
As shown in Table 1, Chinese medicine composition of the invention can significantly reduce the blood glucose of diabetes rat compared with model control group, There is remarkable result to treating diabetes.
Test example 2
Clinical data
1, general information：
Case-data is selected from inpatient in May, -2017 in June, 2,013 240, is randomly divided into test group 120, wherein man Property 60, women 60；Control group 120, wherein male 60, women 60.Test group and control group age are in 35-65 Year, the ratio between men and women and the journey DEG C that is in a bad way are comparable through Chi-square Test no significant difference (P ＞ 0.05).
2, diagnostic criteria and criterion of therapeutical effect：
(1) diagnostic criteria：Case is selected according to WHO diabetes diagnostic criterions, is type 2 diabetes patient, and meet《Chinese medicine The guideline of clinical investigations of Drugs in Therapy diabete (diabetes)》The middle dialectical standard of deficiency of both qi and yin disease.
(2) curative effect determinate standard
It is formulated according to the Ministry of Public Health《New Chinese medicine treats the guideline of clinical investigations of diabete (diabetes)》In curative effect sentence Calibration standard is judged.
A, effective：Treatment declines 30% or more before blood glucose numerical value is relatively treated after two months；
B, effectively：Treatment declines 29-10% before blood glucose numerical value is relatively treated after two months；
C, invalid：Treatment unchanged before blood glucose numerical value is relatively treated or 10% or less decline after two months.
3, clinical testing procedure：
(1) dosage regimen
Test group takes the Chinese medicine composition of the preparation of the embodiment of the present invention 1, takes orally, 2 times a day, 4 tablets each time；Control group, which is taken, to disappear Thirsty Jiangtang capsule (Guangxi Tian medicine companies Co., Ltd, Chinese medicines quasi-word：Z20083229), take orally, 3 times a day, 3 tablets each time； Test group and control group medication course are 60 days.
(2) observation index
Fasting blood-glucose and postprandial 2 hours blood glucose.
4, clinical treatment outcome
Test group and the therapeutic effect of control group are shown in Table 2.The result shows that the clinical obvious effective rate of test group is 70.8%, it is total effective Rate is 94.0%, is better than control group.Show that the Chinese medicine composition of the present invention is curative for effect.Pretherapy and post-treatment test group and control group blood
The variation of sugared numerical value is shown in Table 2.
1 test group of table and control group curative effect compare
Group Number of cases Effective number Significant figure Invalid number It is efficient（%）
Test group 120 85 28 7 94.0
Control group 120 80 27 13 89.0
2 pretherapy and post-treatment blood glucose numerical value change of table
Fasting blood-glucose numerical value compared with pre-treatment,*P ＜ 0.01；2h-plasma glucose numerical value compared with pre-treatment,*#P ＜ 0.01.
In conclusion the present invention utilizes the compatibility between each component of Chinese medicine, enabling effectively activation inertia insulin, Reduce blood glucose so that inertia insulin activity recovery normally participates in glycometabolism, improves human body itself to the utilization of blood glucose and turns Change ability, reaching balance reduces blood glucose, can protect islet cells, inhibits insulin failure, in the pancreas islet that may participate in glycometabolism In the case that element increases, pancreas islet need not hypersecretion as before insulin, pancreas burden mitigates, and obtains necessary stop It is whole, and then play the role of protection pancreas islet, inhibit islet failure.
Although it is upper described be merely a preferred embodiment of the present invention only, be not intended to restrict the invention, with reference to aforementioned implementation Example invention is explained in detail, for those skilled in the art, its still can be to foregoing embodiments Recorded technical solution is modified or equivalent replacement of some of the technical features.All spirit in the present invention With within principle, any modification, equivalent replacement, improvement and so on, should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of Chinese medicine composition for treating diabetes, which is characterized in that the raw material composition and ratio of the Chinese medicine composition are such as Under：10-30 parts of radix scrophulariae, 30-60 parts of sealwort, 15-30 parts of Radix Paeoniae Alba, 15-30 parts of Radix Rehmanniae, 15-30 parts of Poria cocos, 10-30 parts of the fleece-flower root, 10-20 parts of the membrane of a chicken's gizzard, 10-15 parts of rhizoma anemarrhenae, 10-20 parts of coix seed, 10-20 parts of stringy stonecrop, 10-15 parts of rhizoma alismatis, Schisandra chinensis 6-15 Part, 15-40 parts of Radix Salviae Miltiorrhizae, 10-20 parts of Fructus Corni, 15-30 parts of the coptis, 10-20 parts of Radix Notoginseng, 15-60 parts of glutinous rehmannia, 10-30 parts of giant knotweed, 10-30 parts of Rabdosia rubescens, 10-15 parts of matrimony vine.
2. the Chinese medicine composition for the treatment of diabetes according to claim 1, which is characterized in that the original of the Chinese medicine composition Expect that composition and ratio are as follows：15-25 parts of radix scrophulariae, 40-50 parts of sealwort, 19-26 parts of Radix Paeoniae Alba, 19-26 parts of Radix Rehmanniae, 19-26 parts of Poria cocos, 15-25 parts of the fleece-flower root, 13-17 parts of the membrane of a chicken's gizzard, 11-13 parts of rhizoma anemarrhenae, 12-17 parts of coix seed, 13-17 parts of stringy stonecrop, rhizoma alismatis 11-14 Part, 8-12 parts of Schisandra chinensis, 23-32 parts of Radix Salviae Miltiorrhizae, 13-17 parts of Fructus Corni, 19-26 parts of the coptis, 12-17 parts of Radix Notoginseng, glutinous rehmannia 30-45 Part, 15-25 parts of giant knotweed, 15-25 parts of Rabdosia rubescens, 12-14 parts of matrimony vine.
3. the Chinese medicine composition for the treatment of diabetes according to claim 2, which is characterized in that the original of the Chinese medicine composition Expect that composition and ratio are as follows：20 parts of radix scrophulariae, 45 parts of sealwort, 23 parts of Radix Paeoniae Alba, 23 parts of Radix Rehmanniae, 23 parts of Poria cocos, 20 parts of the fleece-flower root, in chicken 15 parts of gold, 12 parts of rhizoma anemarrhenae, 15 parts of coix seed, 15 parts of stringy stonecrop, 12 parts of rhizoma alismatis, 11 parts of Schisandra chinensis, 28 parts of Radix Salviae Miltiorrhizae, Fructus Corni 15 Part, 23 parts of the coptis, 15 parts of Radix Notoginseng, 38 parts of glutinous rehmannia, 20 parts of Rabdosia rubescens, 20 parts of matrimony vine.
4. the Chinese medicine composition for the treatment of diabetes according to claim 1, which is characterized in that the Chinese medicine composition passes through Decoction, granule, tablet, pill, capsule and pill is made in addition auxiliary material.
5. the Chinese medicine composition for the treatment of diabetes according to claim 4, which is characterized in that the auxiliary material is dextrin, breast Sugar, starch, sucrose, glucose, microcrystalline cellulose, mannose, methylcellulose, carboxy-propyl cellulose, carboxymethyl cellulose and The one or more of stevioside.
6. treating the preparation method of the Chinese medicine composition of diabetes according to claim 1-5 any one of them, which is characterized in that It includes the following steps：
（1）Bulk pharmaceutical chemicals are weighed according to the ratio, are put it into marmite, the dipped powder 2-4cm of clear water are added, and impregnate 10-20min；
（2）First the bulk pharmaceutical chemicals being immersed in marmite clear water are boiled with high heat, are changed to be cooked by slow fire 20-30min later, then Decocting liquid is filtered to take, it is spare；
（3）It will be in step（2）Remaining filter residue is filtered successively according to step（1）And step（2）Operating method, carry out again Processing, filters to take decocting liquid, spare；
（4）By step（2）And step（3）It is 1.20-1.30 that the decocting liquid mixing of middle acquisition, which is concentrated into close DEG C relatively, is slowly added into 2 The 90%v/v ethanol solutions of amount again stir, and stand, filtering, and filtrate low-temperature evaporation is concentrated into close DEG C relatively as 1.40-1.50, and Ethyl alcohol is recycled, concentrate is obtained；
（5）Concentrate plus water and auxiliaries are spray-dried at decoction, or by concentrate, capsule, piece is made in addition auxiliary material Agent, pill, granule.
7. the preparation method of the Chinese medicine composition for the treatment of diabetes according to claim 6, which is characterized in that step（4） In, the mixing time is 18-25 minutes.
8. the preparation method of the Chinese medicine composition for the treatment of diabetes according to claim 6, which is characterized in that step（4） In, the time of repose is 35-55 hours.
9. the preparation method of the Chinese medicine composition for the treatment of diabetes according to claim 6, which is characterized in that step（4） In, spray drying condition is：It it is 100-120 DEG C into wind-warm syndrome DEG C, outlet temperature DEG C is 80-90 DEG C, and material temperature DEG C is 70-90 DEG C, mist Change pressure is 0.2-0.4MPa, and spraying speed DEG C is 5-10ml/s.
10. the preparation method of the Chinese medicine composition for the treatment of diabetes according to claim 9, which is characterized in that step（5） In, spray drying condition is：It it is 110 DEG C into wind-warm syndrome DEG C, outlet temperature DEG C is 85 DEG C, and material temperature DEG C is 80 DEG C, and atomizing pressure is 0.3MPa, spraying speed DEG C are 7.5ml/s.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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CN102961596A (en) * 2012-12-08 2013-03-13 南京正宽医药科技有限公司 Traditional Chinese medicine composition for treating diabetes as well as preparation method and application of for traditional Chinese medicine composition
CN104815166A (en) * 2015-05-13 2015-08-05 鲁东大学 Traditional Chinese medicine composition for treating diabetes as well as preparation and application of traditional Chinese medicine composition

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Publication number Priority date Publication date Assignee Title
CN1331990A (en) * 2001-05-23 2002-01-23 郑国芃 Chinese medicine for treating diabetes
CN101524471A (en) * 2008-03-06 2009-09-09 北京中科仁和科技有限公司 Pharmaceutical composition for treating diabetes and preparation method thereof
CN102961596A (en) * 2012-12-08 2013-03-13 南京正宽医药科技有限公司 Traditional Chinese medicine composition for treating diabetes as well as preparation method and application of for traditional Chinese medicine composition
CN104815166A (en) * 2015-05-13 2015-08-05 鲁东大学 Traditional Chinese medicine composition for treating diabetes as well as preparation and application of traditional Chinese medicine composition

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109172781A (en) * 2018-11-22 2019-01-11 致宁医药（肇庆）股份有限公司 A kind of Chinese medicine composition for treating hepatitis B, cirrhosis

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