CN106692698B

CN106692698B - Bletilla striata cough relieving granule and preparation method thereof

Info

Publication number: CN106692698B
Application number: CN201710062580.0A
Authority: CN
Inventors: 晏前海; 龙娴郦
Original assignee: Guizhou Province Wuling Mountain Medicinal Plants Baiji Development Co ltd
Current assignee: Guizhou Province Wuling Mountain Medicinal Plants Baiji Development Co ltd
Priority date: 2017-01-24
Filing date: 2017-01-24
Publication date: 2021-03-19
Anticipated expiration: 2037-01-24
Also published as: CN106692698A

Abstract

A cough relieving granule prepared from bletilla striata and a preparation method thereof relate to the technical field of traditional Chinese medicines. The bletilla striata cough relieving granule is prepared from main materials and auxiliary materials, wherein the main materials comprise 0.8-1.5 parts by weight of traditional Chinese medicine extract; the auxiliary materials comprise 20-60 parts of filler, 0.2-3 parts of binder and 0.1-4 parts of flavoring agent; the traditional Chinese medicine extract is mainly prepared from the following traditional Chinese medicine raw materials: bletilla striata, rhizoma polygonati, asparagus cochinchinensis, dendrobium, root of straight ladybell, cortex lycii radicis, cortex mori radicis, radix paeoniae alba, loquat leaf, flos farfarae, radix asteris and liquorice. The cough relieving bletilla striata granules have the effects of tonifying qi and yin, clearing lung and reducing internal heat, and promoting fluid production to relieve cough, and have obvious curative effect on chronic cough. The preparation method mainly comprises mixing the Chinese medicinal extract, part of filler and part of correctant for the first time, adding binder, the rest filler and the rest correctant, mixing, granulating, and making into granule. The preparation method is simple to operate, and the prepared bletilla striata cough relieving granules are good in curative effect.

Description

Bletilla striata cough relieving granule and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and in particular relates to bletilla striata cough relieving granules and a preparation method thereof.

Background

Cough is a self-defense measure of an organism, foreign matters in respiratory tracts are discharged out of the body by secreting viscous liquid, and the cough is defined in China since ancient times: the term "cough is indicated when there is sound or no phlegm, while cough is indicated when there is no sound or phlegm, but cough is indicated when both of them occur at the same time. Wherein, the chronic cough and the chronic cough in the category of the traditional Chinese medicine mean that the cough time is more than or equal to 8 weeks, and the clinical manifestations mainly comprise repeated cough, chronic cough, dry throat, pharynx itch and a little sticky phlegm. "Chronic cough" and "chronic cough" are called chronic cough in modern medicine.

In the course of treatment, western medicine can repeatedly use antibiotics or antiviral drugs in most cases, which not only damages the viscera, but also has great possibility of endowing bacterial drug resistance. In the traditional Chinese medicine treatment, cough and asthma relieving medicines are generally selected as monarch medicines, and meanwhile, the medicine has single dosage form, easily lost active ingredients and poor treatment effect.

Disclosure of Invention

The invention aims to provide bletilla striata cough relieving granules, which have the effects of tonifying qi and yin, clearing lung and reducing internal heat, and promoting fluid production to relieve cough, and have obvious curative effect on chronic cough.

The other purpose of the invention is to provide a preparation method of the cough-relieving bletilla striata granules, which is prepared separately according to different medicinal properties of traditional Chinese medicinal materials, so that more medicinal active ingredients can be obtained; meanwhile, the filler and the flavoring agent are added and mixed twice before granulation, so that the active ingredients are more uniformly distributed, and the prepared granules are more uniform in shape and easy to take.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

The invention provides cough-relieving bletilla striata granules which are prepared from main materials and auxiliary materials, wherein the main materials comprise 0.8-1.5 parts by weight of traditional Chinese medicine extract; the auxiliary materials comprise 20-60 parts of filler, 0.2-3 parts of binder and 0.1-4 parts of flavoring agent; the traditional Chinese medicine extract is mainly prepared from the following traditional Chinese medicine raw materials: 6-15 parts of bletilla striata, 7-12 parts of rhizoma polygonati, 5-11 parts of asparagus cochinchinensis, 5-10 parts of dendrobium, 6-10 parts of adenophora stricta, 7-12 parts of cortex lycii radicis, 6-12 parts of cortex mori radicis, 6-14 parts of radix paeoniae alba, 5-10 parts of folium eriobotryae, 5-9 parts of flos farfarae, 5-9 parts of radix asteris and 2-10 parts of liquorice.

The invention provides a preparation method of cough-relieving bletilla striata granules, which adopts supercritical CO₂The fluid extraction method comprises the steps of extracting bletilla striata at 55-60 ℃ under the condition of 10-35 MPa, wherein ethanol or acetone is selected as an entrainer used for extraction, and an extract liquid is obtained;

pulverizing rhizoma polygonati, radix asparagi, radix adenophorae, cortex lycii radicis, cortex mori radicis and liquorice into powder of 20-100 meshes, decocting the powder with 1.5-5 times of water, precipitating with ethanol, and recovering the ethanol to obtain first liquid medicine;

after refining the honey from the common coltsfoot flower and the tatarian aster root, decocting the mixture by using water to obtain a second liquid medicine;

extracting volatile oil of radix Paeoniae alba and folium Eriobotryae with water, and recovering residue of radix Paeoniae alba and folium Eriobotryae; decocting the residue with water to obtain a third medicinal liquid;

mixing the extract, the first liquid medicine, the second liquid medicine and the third liquid medicine, concentrating and drying to obtain an extract with the relative density of 1.25-1.65, and mixing the extract with volatile oil to prepare a traditional Chinese medicine extract;

mixing the traditional Chinese medicine extract paste, 60-75% of the total mass of the filler and 40-55% of the total mass of the flavoring agent for the first time, then adding the binder, the rest part of the filler and the rest part of the flavoring agent, mixing, granulating, and preparing the bletilla striata cough relieving granule.

The cough relieving bletilla striata granules and the preparation method thereof provided by the embodiment of the invention have the beneficial effects that:

(1) the formula of the traditional Chinese medicine extract paste in the bletilla striata cough relieving granule follows the rule of 'monarch, minister, assistant and guide' in the traditional formula of the traditional Chinese medicine, wherein monarch medicines are rhizoma polygonati, dendrobium and asparagus; the ministerial drugs are bletilla striata and adenophora stricta; the adjuvant drugs are cortex Lycii, cortex Mori, folium Eriobotryae, radix Paeoniae alba, flos Farfarae and radix Asteris; the guiding drug is liquorice.

The formula mainly aims at tonifying qi and nourishing yin, clearing lung and reducing internal heat, and promoting fluid production to relieve cough, and has obvious curative effect on chronic cough. Wherein, the sealwort tonifies qi and nourishes yin, strengthens spleen and moistens lung; radix asparagi has effects of nourishing yin, moistening dryness, clearing lung-heat and promoting fluid production; herba Dendrobii has effects of nourishing yin, clearing heat, promoting fluid production, and quenching thirst; the compatibility of the three herbs can tonify lung qi, so they are the monarch drugs. Bletilla striata, good for entering lung, combined with qi tonics, can assist in tonifying lung qi, and at the same time, bletilla striata can astringe qi, so that lung qi is collected in the lung, and the curative effects of tonifying qi and nourishing yin are enhanced; radix Adenophorae has the effects of nourishing yin and clearing away lung-heat; auxiliary monarch drugs are used for tonifying lung qi, so the monarch drugs and the ministerial drugs are used together. Cortex Lycii, clearing lung-heat and purging fire, is sweet and cold, enters blood system, clears heat and cools blood; cortex Mori has effects in purging lung-fire and relieving asthma; loquat leaves can clear away the lung-heat, relieve cough, check adverse rise of qi and arrest vomiting; the white peony root has the effects of nourishing blood, astringing yin, calming liver yang and enhancing the immunity of the organism; flos Farfarae and radix Asteris have effects of moistening lung, descending qi, relieving cough and eliminating phlegm; the six medicines are combined to clear lung and remove toxicity, and are adjuvant medicines with the functions of assisting ministerial medicines, eliminating dampness and turbidity and strengthening dispersing wind and evil. Licorice root, radix Glycyrrhizae, as a guiding drug, has the effects of tonifying spleen and qi, expelling phlegm to arrest coughing, relieving spasm and pain, and harmonizing the drugs in the recipe.

(2) Compared with antibiotics, the bletilla striata cough relieving granules prepared by selecting the main materials as the traditional Chinese medicinal materials are not easy to generate the drug resistance condition, are safe and have no side effect.

(3) The main material and the auxiliary material play a synergistic role, and the cough relieving granules of bletilla can conform to pharmacodynamic characteristics in a body, such as easy absorption, easy transformation and easy excretion.

(4) The preparation method of the cough-relieving bletilla striata granules is separately prepared according to different medicinal properties of traditional Chinese medicinal materials, and compared with preparations such as decoction in the traditional Chinese medicinal preparation or other extraction methods, the preparation method can obtain more medicinal active ingredients; secondly, before granulation, the filler and the flavoring agent are added and mixed for two times, so that the active ingredients are more uniformly distributed, the prepared granules are more uniform in shape and easy to take, and the treatment effect is better.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

The cough stopping granules prepared from bletilla striata and the preparation method thereof according to the embodiment of the invention are specifically described below.

The cough relieving bletilla striata granule provided by the embodiment of the invention is prepared from main materials and auxiliary materials, wherein the main materials comprise 0.8-1.5 parts by weight of traditional Chinese medicine extract; the auxiliary materials comprise 20-60 parts of filler, 0.2-3 parts of binder and 0.1-4 parts of flavoring agent; the traditional Chinese medicine extract is mainly prepared from the following traditional Chinese medicine raw materials: 6-15 parts of bletilla striata, 7-12 parts of rhizoma polygonati, 5-11 parts of asparagus cochinchinensis, 5-10 parts of dendrobium, 6-10 parts of adenophora stricta, 7-12 parts of cortex lycii radicis, 6-12 parts of cortex mori radicis, 6-14 parts of radix paeoniae alba, 5-10 parts of folium eriobotryae, 5-9 parts of flos farfarae, 5-9 parts of radix asteris and 2-10 parts of liquorice.

Further, in a preferred embodiment of the present invention, in parts by weight, 12 parts of bletilla striata, 8 parts of polygonatum sibiricum, 8 parts of asparagus cochinchinensis, 8 parts of dendrobium nobile, 8 parts of adenophora stricta, 10 parts of cortex lycii radicis, 9 parts of cortex mori, 10 parts of radix paeoniae alba, 8 parts of loquat leaves, 8 parts of flos farfarfarae, 6 parts of aster and 6 parts of liquorice are included.

The formula of the traditional Chinese medicine extract paste in the bletilla striata cough relieving granule follows the rule of 'monarch, minister, assistant and guide' in the traditional formula of the traditional Chinese medicine, wherein monarch medicines are rhizoma polygonati, dendrobium nobile and asparagus cochinchinensis; the ministerial drugs are bletilla striata and adenophora stricta; the adjuvant drugs are cortex Lycii, cortex Mori, folium Eriobotryae, radix Paeoniae alba, flos Farfarae, and radix Asteris; the guiding drug is liquorice.

The book of Jingyue (the book of Jingyue): "cough is abundant, but without non-lung disease. It is the explanation of "the cause of cough is mainly lung". Therefore, the formula mainly aims at tonifying qi and nourishing yin, clearing away lung-heat and reducing internal heat, and promoting the production of body fluid to relieve cough, and has obvious curative effect on treating chronic cough.

Wherein, the sealwort tonifies qi and nourishes yin, strengthens spleen and moistens lung; radix asparagi has effects of nourishing yin, moistening dryness, clearing lung-heat and promoting fluid production; herba Dendrobii has effects of nourishing yin, clearing heat, promoting fluid production, and quenching thirst; the compatibility of the three herbs can tonify lung qi, so they are the monarch drugs.

Bletilla striata, good for entering lung, combined with qi tonics, can assist in tonifying lung qi, and at the same time, bletilla striata can astringe qi, so that lung qi is collected in the lung, and the curative effects of tonifying qi and nourishing yin are enhanced; radix Adenophorae has the effects of nourishing yin and clearing away lung-heat; auxiliary monarch drugs are used for tonifying lung qi, so the Chinese medicinal composition is used as a ministerial drug. Wherein, the bletilla striata is bitter and sweet in taste and cool in nature, white in color and enters the lung, so that the bletilla striata can astringe to stop bleeding, relieve swelling and promote tissue regeneration for the former, and the bletilla striata is found to be good at relieving cough, especially has good effect on cough due to yin deficiency, cough due to lung heat, pertussis and phthisis cough.

Cortex Lycii, clearing lung-heat and purging fire, is sweet and cold, enters blood system, clears heat and cools blood; cortex Mori has effects in purging lung-fire and relieving asthma; loquat leaves can clear away the lung-heat, relieve cough, check adverse rise of qi and arrest vomiting; the white peony root has the effects of nourishing blood, astringing yin, calming liver yang and enhancing the immunity of the organism; flos Farfarae and radix Asteris have effects of moistening lung, descending qi, relieving cough and eliminating phlegm; the six medicines are combined to clear lung and remove toxicity, reduce swelling and dissipate stagnation, and are adjuvant medicines with the functions of assisting ministerial medicines, eliminating dampness and turbidity and strengthening dispersing wind evil.

Licorice root, radix Glycyrrhizae, as a guiding drug, has the effects of tonifying spleen and qi, expelling phlegm to arrest coughing, relieving spasm and pain, and harmonizing the drugs in the recipe.

Further, in a preferred embodiment of the invention, the traditional Chinese medicine raw material medicine also comprises 2-5 parts by weight of bitter apricot seeds. Preferably, the bitter almond is 4 parts. Bitter apricot kernel has the function of dispersing wind-cold, and has the functions of descending qi and relieving asthma; can diffuse lung qi when being combined with qi tonics; it excels in relieving cough and resolving phlegm, and has strong pertinence to cough, which is the main disease of lung system. Modern pharmacology considers that the bitter almond contains amygdalin and amygdalin, the amygdalin can be hydrolyzed by the amygdalin, and the generated hydrocyanic acid and benzaldehyde have inhibition effect on the respiratory center, so that the respiration can be deepened, and the cough can be relieved; however, excessive hydrocyanic acid and benzaldehyde are harmful to the body, so the use or dosage of bitter apricot seeds needs to be controlled, and the bitter apricot seeds have the effect of adjuvant therapy.

Further, in the preferred embodiment of the present invention, the root of straight ladybell is radix glehniae. Radix Adenophorae is divided into radix Glehniae and radix Adenophorae, which can nourish yin and clear away lung-heat; the actions of Bei Sha Shen are stronger than nan Sha Shen, which is slightly weaker.

Further, in the preferred embodiment of the present invention, the licorice is prepared licorice. The honey-fried licorice root is prepared by processing licorice root with honey, and the honey-fried licorice root added with the honey can assist in relieving cough.

The invention also provides a preparation method of the bletilla striata cough relieving granules, which adopts supercritical CO₂The fluid extraction method comprises the steps of extracting bletilla striata at 55-60 ℃ under the condition of 10-35 MPa, wherein ethanol or acetone is selected as an entrainer used for extraction, and an extract liquid is obtained;

Further, in the preferred embodiment of the present invention, the particle size of the powder is 20 to 100 mesh.

Further, in a preferred embodiment of the present invention, before extracting the bletilla striata, a step of drying the bletilla striata at 45-50 ℃ is further included.

Further, in a preferred embodiment of the present invention, the auxiliary material further comprises at least one of a lubricant, a disintegrant and a preservative.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The embodiment provides a bletilla striata cough relieving granule, which comprises the following components in parts by weight: 0.8 part of Chinese medicine extract, 20 parts of starch, 1 part of polyethylene glycol, 0.2 part of saccharin sodium and 0.2 part of magnesium oxide.

0.8 part of traditional Chinese medicine extract paste is prepared from the following traditional Chinese medicine raw materials: 6 parts of bletilla striata, 7 parts of sealwort, 5 parts of asparagus, 6 parts of adenophora stricta, 7 parts of cortex lycii radicis, 6 parts of cortex mori radicis, 6 parts of radix paeoniae alba, 5 parts of loquat leaf, 5 parts of dendrobe, 5 parts of coltsfoot flower, 5 parts of radix asteris, 2 parts of liquorice and 2 parts of bitter almond.

The preparation method comprises the following steps:

(1) drying rhizoma Bletillae at 45 deg.C;

(2) by using supercritical CO₂Extracting rhizoma Bletillae with ethanol at 58 deg.C under 10MPa to obtain extractive solution;

(3) pulverizing rhizoma Polygonati, radix asparagi, radix Adenophorae, cortex Lycii, cortex Mori, Glycyrrhrizae radix and semen Armeniacae amarum into 20 mesh powder, decocting the powder with 4 times of water, precipitating with ethanol, and recovering ethanol to obtain first medicinal liquid;

(4) after refining the honey from the common coltsfoot flower and the tatarian aster root, decocting the mixture by using water to obtain a second liquid medicine;

(5) extracting volatile oil of radix Paeoniae alba and folium Eriobotryae with water, and recovering residue of radix Paeoniae alba and folium Eriobotryae; decocting the residue with water to obtain a third medicinal liquid;

(6) mixing the extractive solution, the first medicinal liquid, the second medicinal liquid and the third medicinal liquid, concentrating, drying to obtain extract with relative density of 1.25, mixing the extract with volatile oil, and making into Chinese medicinal extract;

(7) mixing the Chinese medicinal extract, 60% starch (12 parts), 40% saccharin sodium (0.08 part) and magnesium oxide, adding polyethylene glycol, the rest of starch and the rest of saccharin sodium, mixing, wet granulating, and making into granule.

Example 2

The embodiment provides a bletilla striata cough relieving granule, which comprises the following components in parts by weight: 1.2 parts of traditional Chinese medicine extract paste; 40 parts of lactose, 0.6 part of carboxypropyl cellulose, 0.5 part of stevioside, 0.3 part of magnesium stearate and 0.1 part of microcrystalline cellulose.

1.2 parts of traditional Chinese medicine extract paste is prepared from the following traditional Chinese medicine raw materials: 12 parts of bletilla striata, 8 parts of rhizoma polygonati, 8 parts of asparagus cochinchinensis, 8 parts of radix glehniae, 10 parts of cortex lycii radicis, 9 parts of cortex mori radicis, 10 parts of radix paeoniae alba, 8 parts of folium eriobotryae, 8 parts of dendrobe, 8 parts of flos farfarfarae, 6 parts of radix asteris, 6 parts of radix glycyrrhizae preparata and 4 parts of bitter almond.

The preparation method comprises the following steps:

(1) drying rhizoma Bletillae at 50 deg.C;

(2) by using supercritical CO₂Extracting rhizoma Bletillae with ethanol at 55 deg.C under 20MPa to obtain extractive solution;

(3) pulverizing rhizoma Polygonati, radix asparagi, radix Adenophorae, cortex Lycii, cortex Mori, Glycyrrhrizae radix and semen Armeniacae amarum into 60 mesh powder, decocting the powder with 3 times of water, precipitating with ethanol, and recovering ethanol to obtain first medicinal liquid;

(6) mixing the extractive solution, the first medicinal liquid, the second medicinal liquid and the third medicinal liquid, concentrating, drying to obtain extract with relative density of 1.35, mixing the extract with volatile oil, and making into Chinese medicinal extract;

(7) mixing the traditional Chinese medicine extract, 65% of lactose (26 parts of lactose), 50% of stevioside (0.25 part of stevioside), magnesium stearate and microcrystalline cellulose for the first time, adding the carboxypropyl cellulose, the rest part of the lactose and the rest part of the stevioside, mixing, performing dry granulation, and preparing the bletilla striata cough relieving granule.

Example 3

The embodiment provides a bletilla striata cough relieving granule, which comprises the following components in parts by weight: 1 part of Chinese medicine extract, 50 parts of lactose, 3 parts of starch slurry, 0.1 part of stevioside and 0.4 part of talcum powder.

1 part of the traditional Chinese medicine extract paste is prepared from the following traditional Chinese medicine raw materials: 10 parts of bletilla striata, 9 parts of rhizoma polygonati, 9 parts of asparagus, 9 parts of radix glehniae, 9 parts of cortex lycii radicis, 8 parts of cortex mori radicis, 7 parts of radix paeoniae alba, 8 parts of loquat leaves, 9 parts of dendrobe, 7 parts of flos farfarae, 7 parts of radix asteris and 7 parts of liquorice.

The preparation method comprises the following steps:

(1) drying rhizoma Bletillae at 48 deg.C;

(2) by using supercritical CO₂Extracting rhizoma Bletillae with fluid extraction method at 60 deg.C under 30MPa, wherein the entrainer is acetone to obtain extractive solution;

(3) pulverizing rhizoma Polygonati, radix asparagi, radix Glehniae, cortex Lycii, cortex Mori, and Glycyrrhrizae radix into 45 mesh powder, decocting the powder with 2.5 times of water, precipitating with ethanol, and recovering ethanol to obtain first medicinal liquid;

(6) mixing the extractive solution, the first medicinal liquid, the second medicinal liquid and the third medicinal liquid, concentrating, drying to obtain extract with relative density of 1.65, mixing the extract with volatile oil, and making into Chinese medicinal extract;

(7) mixing the Chinese medicinal extract, 65% lactose (32.5 parts), 55% stevioside (0.055 part) and pulvis Talci for the first time, adding starch slurry, mixing with the rest part of lactose and stevioside, and wet granulating to obtain rhizoma bletilla granule for relieving cough.

Example 4

The embodiment provides a bletilla striata cough relieving granule, which comprises the following components in parts by weight: 1.5 parts of traditional Chinese medicine extract; 60 parts of cane sugar, 0.8 part of sodium methyl cellulose, 0.4 part of stevioside, 0.3 part of magnesium stearate, 0.2 part of starch and 0.1 part of sodium benzoate.

1.5 parts of traditional Chinese medicine extract paste is prepared from the following traditional Chinese medicine raw materials: 15 parts of bletilla striata, 12 parts of rhizoma polygonati, 11 parts of asparagus, 10 parts of adenophora tetraphylla, 12 parts of cortex lycii radicis, 12 parts of cortex mori radicis, 14 parts of radix paeoniae alba, 10 parts of loquat leaves, 10 parts of dendrobe, 9 parts of tussilago farfara, 9 parts of radix asteris, 10 parts of radix glycyrrhizae preparata and 5 parts of bitter apricot seeds.

The preparation method comprises the following steps:

(1) by using supercritical CO₂Extracting rhizoma Bletillae with ethanol at 55 deg.C under 25MPa to obtain extractive solution;

(2) pulverizing rhizoma Polygonati, radix asparagi, radix Adenophorae, cortex Lycii, cortex Mori, Glycyrrhrizae radix and semen Armeniacae amarum into 100 mesh powder, decocting the powder with 1.5 times of water, precipitating with ethanol, and recovering ethanol to obtain first medicinal liquid;

(3) after refining the honey from the common coltsfoot flower and the tatarian aster root, decocting the mixture by using water to obtain a second liquid medicine;

(4) extracting volatile oil of radix Paeoniae alba and folium Eriobotryae with water, and recovering residue of radix Paeoniae alba and folium Eriobotryae; decocting the residue with water to obtain a third medicinal liquid;

(5) mixing the extractive solution, the first medicinal liquid, the second medicinal liquid and the third medicinal liquid, concentrating, drying to obtain extract with relative density of 1.45, mixing the extract with volatile oil, and making into Chinese medicinal extract;

(6) mixing the Chinese medicinal extract, 75% sucrose (45 parts) and 45% stevioside (0.18 part), adding sodium methylcellulose, magnesium stearate, starch, sodium benzoate, the rest part of sucrose and the rest part of stevioside, mixing, wet granulating, and making into granule.

Comparative example 1

A cough relieving medicine is prepared from the following traditional Chinese medicine raw materials: 12 parts of bletilla striata, 8 parts of rhizoma polygonati, 8 parts of asparagus cochinchinensis, 8 parts of radix glehniae, 10 parts of cortex lycii radicis, 9 parts of cortex mori radicis, 10 parts of radix paeoniae alba, 8 parts of folium eriobotryae, 8 parts of dendrobe, 8 parts of flos farfarfarae, 6 parts of radix asteris, 6 parts of radix glycyrrhizae preparata and 4 parts of bitter almond.

The preparation method comprises the following steps: the Chinese medicinal raw materials are prepared into decoction.

Comparative example 2

A cough relieving medicine is prepared from the following traditional Chinese medicine raw materials: 8 parts of sealwort, 8 parts of asparagus fern, 8 parts of radix glehniae, 10 parts of cortex lycii radicis, 9 parts of white mulberry root-bark, 10 parts of white paeony root, 8 parts of loquat leaf, 8 parts of dendrobium, 8 parts of common coltsfoot flower, 6 parts of radix asteris, 6 parts of liquorice and 4 parts of bitter apricot seed.

Comparative example 3

A cough relieving medicine is prepared from the following raw material medicines: 5 parts of Chinese date, 2 parts of hawthorn, 2 parts of fructus forsythiae, 1 part of ephedra, 3 parts of poria cocos, 1 part of cassia twig, 2 parts of radix ophiopogonis, 2 parts of dried orange peel, 3 parts of mangnolia officinalis, 1 part of rhizoma anemarrhenae, 1 part of periostracum cicada, 1 part of fritillaria, 4 parts of platycodon grandiflorum, 2 parts of herba epimedii, 5 parts of medlar, 1 part of flos farfarae, 3 parts of mint, 2 parts of bletilla striata, 3 parts of radix stemonae, 2 parts of angelica sinensis and 2 parts of radix angelicae.

The preparation method comprises the steps of putting the raw materials into a container, adding cold water to overflow the surface of the raw materials, soaking for 12-20 minutes, adding water to submerge the surface of the raw materials by about 8 cm, and decocting. Before boiling, the raw materials are decocted for 20-20 minutes by strong fire; and (4) carrying out second decoction, wherein after the water is boiled, the decoction is carried out for 15-20 minutes by slow fire. Decocting twice, removing residue, collecting decoction, and mixing.

Test example 1 examination of antitussive Effect

(1) Test animals: 80 mice were collected and used for both male and female, with a body mass (20. + -.2) g.

(2) Grouping: mice are preselected, qualified mice are bred for 3 days, and then randomly divided into 8 groups, which respectively correspond to examples 1-4, comparative examples 1-3 and a blank control group (physiological saline 0.2ml/10g), wherein each group contains 10 mice.

(3) The test method comprises the following steps:

the cough suppressing granules of bletilla striata provided in examples 1 to 4 were dissolved in warm water of 40 ℃ and the same volume to obtain a drug solution (concentration was 2 g/ml).

The liquid medicine of each example and the decoction of comparative examples 1-3 (the concentration is 2g/ml) are administered to the mice by intragastric administration for 1 time/d according to the weight of 0.2ml/10g (body mass) and are administered for 3 days by continuous intragastric administration. After the last administration for 1h, the mice are respectively placed in an inverted 5L closed glass bell one by one, a power switch is turned on, a vacuum pump is started, a pressure gauge is adjusted to 160mmHg, the mice receive constant-pressure ammonia water spray stimulation, the stimulation is stopped after 15s (the ammonia water spray is carried out for 10 ml/time, 1 mouse is carried out every time, 1 ammonia water exchange is carried out for 1 time), the mice are immediately taken out, and the cough induction incubation period of the mice and the cough frequency within 2min are observed.

Note: the mice were judged to cough by strongly contracting the abdominal muscles and opening the mouth, sometimes with a slight cough sound, with the latency indicating the time from the start of the spray until the onset of cough, as shown in table 1.

TABLE 1 Effect of drugs on ammonia induced cough in mice (x + -s, n ═ 10)

Group of	Incubation period(s)	Number of cough 2min
			Blank control group	26.70±10.62	7.20±2.43
Example 1	112.78±19.85^**	2.92±1.36^**
			Example 2	119.62±22.35^**	1.28±1.07^*
Example 3	108.67±21.03^**	3.23±0.48^*
			Example 4	117.09±21.01^**	1.54±0.85^*
Comparative example 1	101.41±21.03^**	4.87±2.29^*
			Comparative example 2	90.69±15.23^**	5.55±2.69^*
Comparative example 3	98.21±13.67^**	4.56±1.31^*

Note: p <0.05, p <0.01 compared to the blank control group.

The results in table 1 show that the mice corresponding to examples 1 to 4 all cough less frequently within 2min than the mice corresponding to the blank control group and comparative examples 1 to 3, which indicates that the granules provided by examples 1 to 4 have better antitussive effect and significant difference (p <0.05, p <0.01) compared with the blank control group.

Test example 2 clinical test

1. Case selection

350 patients, sex randomized; the age is 15 years minimum and 77 years maximum, all patients have a history of upper respiratory tract infection, the disease course is over 8 weeks, and most of the cases are treated by various antibiotics, hormones and Chinese traditional medicines and are ineffective. The patients were divided into 7 groups of 50 patients each, corresponding to examples 1 to 4 and comparative examples 1 to 3, respectively.

2. Method of treatment

Each group of patients respectively takes the bletilla striata cough relieving granules provided in examples 1-4 and the cough relieving granules provided in comparative examples 1-3 according to a conventional method, 3 times a day and three days as a course of treatment.

3. Criteria for efficacy assessment

And (3) healing: cough and clinical symptoms disappear, physical examination has no positive signs, blood routine and X chest radiography review are normal, and relapse does not occur after stopping taking the medicine.

The effect is shown: cough and clinical symptoms are relieved, physical examination is normal, and mild attack still occurs after peculiar smell stimulation.

And (4) invalidation: after 3 courses of treatment, no improvement was observed in cough and concurrent symptoms.

The clinical efficacy results are shown in table 2.

4. Results and analysis

TABLE 2 clinical curative effect results table (example)

As can be seen from table 2, the total clinical effective rate of patients using the granules for relieving cough prepared from bletilla striata provided in examples 1 to 4 is greater than that of patients corresponding to comparative examples 1 to 3. It is demonstrated that the efficacy of the granule for relieving cough of bletilla striata provided in examples 1 to 4 is better than that of the granules in comparative examples 1 to 3.

Compared with the comparative example 1, in the examples 1 to 4, when the granules are prepared, appropriate auxiliary materials are selected, and the effective components of the traditional Chinese medicine raw materials with different drug properties are extracted by different methods to prepare the granules, so that the cough-relieving efficacy of the bletilla striata cough-relieving granules in the examples 1 to 4 is better.

Compared with the comparative example 2, the bletilla striata traditional Chinese medicine is used in the examples 1-4, the comparative example 1 and the comparative example 3, so that more cases of patients suffering from chronic cough are cured. It is indicated that bletilla striata is an important raw material in treating cough.

It can be seen from the combination of tables 1 and 2 that, compared with example 3, the cough-relieving time of examples 1, 2 and 4 is relatively short, and the total effective rate of the corresponding patients is higher, mainly because of the addition of a small amount of bitter apricot seeds, thereby enhancing the cough-relieving capacity.

Finally, the mice in example 2 had the shortest cough-relieving time and the corresponding total effective rate of the patients was 100%, which indicates that the bletilla striata cough-relieving granules provided in example 2 have the best curative effect. The proportion and the preparation method of the traditional Chinese medicine raw material medicine provided by the embodiment 2 are most scientific and reasonable.

In conclusion, the bletilla striata cough relieving granules and the preparation method thereof provided by the embodiment of the invention have an obvious cough relieving effect.

Typical case 1

Plum, male, 67 years old, Guizhou people, have unhealed cough all the year round, and the patient has continuous cough, itching throat, namely cough, little sticky phlegm, difficult cough and aggravation after smelling peculiar smell. After taking a plurality of Chinese patent medicines, the treatment effect is poor, the cough is obviously relieved after 3 days of using the bletilla striata cough relieving granules provided by the embodiment 2 of the invention, the symptoms are obviously improved, the granules are continuously taken, and the cough is cured after 4 weeks without relapse after follow-up for half a year.

Typical case 2

For a person who is yellow and young, 41 years old and Guizhou, the patient has poor appetite, continuous cough and aggravation after smelling peculiar smell because the cough is not cured for 60 days after the cold. The effect of using various antibiotics is poor, after the bletilla striata cough relieving granules provided by the embodiment 2 of the invention are used for 3 days, the cough is obviously relieved, the symptoms are obviously improved, the granules are continuously taken, and after 1 week, the granules are cured, and no relapse occurs in half a follow-up year.

Typical case 3

Wangzhi, female, 52 years old, Guizhou people, because the cough is not cured for 45 days after the cold, the patient has continuous cough, itching throat and immediate cough, little sticky phlegm, difficult cough and aggravation after smelling peculiar smell. The effect of using various antibiotics in a hospital for half a month is poor, the cough is obviously relieved after 3 days of using the bletilla striata cough relieving granules provided by the embodiment 4 of the invention, the symptoms are obviously improved, the granules are continuously taken, and after 1 week, the granules are cured, and no relapse occurs in half a follow-up visit.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. The cough relieving bletilla striata granule is characterized by being prepared from a main material and an auxiliary material, wherein the main material is 0.8-1.5 parts by weight of a traditional Chinese medicine extract; the auxiliary materials comprise 20-60 parts of filler, 0.2-3 parts of binder and 0.1-4 parts of flavoring agent; the traditional Chinese medicine extract paste is prepared from the following traditional Chinese medicine raw materials: 6-15 parts of bletilla striata, 7-12 parts of rhizoma polygonati, 5-11 parts of asparagus cochinchinensis, 5-10 parts of dendrobium, 6-10 parts of adenophora stricta, 7-12 parts of cortex lycii radicis, 6-12 parts of cortex mori radicis, 6-14 parts of radix paeoniae alba, 5-10 parts of folium eriobotryae, 5-9 parts of flos farfarae, 5-9 parts of radix asteris, 2-10 parts of liquorice and 2-5 parts of bitter apricot seeds.

2. The granule of bletilla striata for relieving cough according to claim 1, wherein the granules of bletilla striata are 12 parts, the sealwort is 8 parts, the asparagus fern is 8 parts, the dendrobium nobile is 8 parts, the adenophora stricta is 8 parts, the cortex lycii radicis is 10 parts, the cortex mori radicis 9 parts, the radix paeoniae alba is 10 parts, the loquat leaves are 8 parts, the coltsfoot flower is 8 parts, the aster tataricus is 6 parts, and the licorice is 6 parts by weight.

3. The granule of bletilla striata for relieving cough according to claim 1, wherein the bitter apricot seeds are 4 parts by weight.

4. The granule of bletilla striata for relieving cough according to claim 1, wherein the root of straight ladybell is radix glehniae.

5. The granule of bletilla striata for relieving cough as claimed in claim 1, wherein the licorice is prepared licorice.