CN104306909A - Traditional Chinese medicine composition for preventing and treating bovine uterus subinvolution and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating bovine uterus subinvolution and preparation method thereof Download PDFInfo
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Abstract
A traditional Chinese medicine composition for preventing and treating bovine uterus subinvolution is composed of the following components in parts by weight: 10 to 30 parts of motherwort, 10 to 30 parts of Chinese angelica, 10 to 30 parts of radix astragali, 10 to 30 parts of dictamnus dasycarpus turcz, 10 to 20 parts of corydalis tuber, 10 to 30 parts of artemisia argyi, 10 to 30 parts of red sage root, 10 to 20 parts of ligusticum wallichii, 10 to 20 parts of roasted ginger, 10 to 20 parts of vinegar-processed rhizoma cyperi, 10 to 20 parts of cuttlebone, 10 to 20 parts of dipsacus root, 10 to 20 parts of fructus forsythiae, 10 to 20 parts of borax, 10 to 20 parts of mint, 10 to 20 parts of pseudo-ginseng, 10 to 20 parts of rhizoma bletillae, and 10 to 20 parts of licorice. The functions of core traditional Chinese herbals of motherwort, Chinese angelica, radix astragali, dictamnus dasycarpus turcz, corydalis tuber, artemisia argyi, and red sage root are integrated, at the same time auxiliary traditional Chinese herbals of ligusticum wallichii, roasted ginger, vinegar-processed rhizoma cyperi, cuttlebone, dipsacus root, fructus forsythiae, borax, mint, pseudo-ginseng, and rhizoma bletillae are added, and a proper preparation method is adopted to prepare the traditional Chinese medicine composition. The traditional Chinese medicine composition has functions of enhancing the uterus smooth muscle contraction, inhibiting bacterium, preventing inflammation, strengthening immunity, stopping bleeding, relieving pains, removing slough and promoting tissue regeneration, is capable of effectively preventing and treating bovine uterus subinvolution, reduces the uterus infection chance, and improves the bovine fertility.
Description
Technical field
The invention belongs to animal medicinal composition, be specifically related to a kind of Chinese medicine composition and preparation method thereof, particularly relate to subinvolution composition and method of making the same in a kind of control cattle uterus.
Background technology
Cattle uterus returns to the past and refers to that, within the regular hour in puerperal, cattle uterus returns to antenatal volume and function.Under normal circumstances, in about 30 days puerperal, cattle uterus returns to volume during unpregnancy, and after 5 ~ 6 weeks, cattle uterus completes restoration of old ways.But, due to cattle usually there is hormone disturbance, placenta retention, inertia of uterus, difficult labour puerperal, fetus is excessive, amniotic fluid is too much, twin pregnancy, the prolapsus uteri, puerperal low blood calcium and uterine cavity in the situation such as bacterial reproduction, thus cause cattle uterus within the normal restoration of old ways time, fail state when returning to unpregnancy and function, namely cattle uterus returns to the past and postpones.The General Symptoms suffering from the cattle that the involution of uterus postpones shows as: body temperature is increased to more than 40 DEG C, and spirit is depressed, and malaise is of flaccid muscles, anus ungauged regions power, slow in action; Local symptom shows as: in initial several days of puerperal, even reaches more than 10 days, loses lochia and discharges from vaginal orifice.Intravaginal check result is: cervical orifice delays to be retracted to normal level.Cattle uterus returns to the past and postpones not only can postpone pregnant time, elongate farrowing spacing, and easily causes the uterine infection of trouble cattle and cause infertile, causes huge loss to cattle-raising.
In order to reduce the economic loss that cattle uterus subinvolution causes, the means of prevention that current people usually adopt comprises following several: (1) rinses purification uterus, conventional washing liquid is by 0.1 ~ 0.2% ethacridine solution, 0.1% compound iodine solution, 0.1 ~ 0.3% potassium permanganate solution, the mixed liquor of 1% alum solution of 0.1 ~ 0.2% sodium bicarbonate solution and equivalent; Washing liquid is poured in cavity of uterus, then discharge with siphonage and pour into intrauterine disinfectant solution, every day 1 time, can even do 3 ~ 4 times, to the liquid-transparent of discharging, get rid of lochia by manual method; (2) rinse uterus to be combined with injection contracting palace hormone, every day or every other day with 5 ~ 10% sodium chloride solution 200 ~ 300ml flushing uterus 1 time, along with the raising of exudate minimizing and strength of uterine contraction, gradually washing liquid concentration is reduced to 1%, and reduces consumption; Subcutaneous or intramuscular injection diethylstilbestrol, oxytocin simultaneously, to promote the contraction in uterus; (3) flushing is combined with intrauterine infusion antibiotic, after flushing also drain, selects each 500,000 ~ 1,000,000 IU of penicillin, streptomycin, or oxytetracycline 0.5g is dissolved in 100ml cod-liver oil, then add pituitrin 5IU, inject intrauterine, every day 1 time, after 4 ~ 6 days 1 time every other day.
The method control cattle uterus subinvolution of antibiotic and antiseptic and disinfectant drug is injected in the many employings of said method in cattle uterus, is difficult to effectively prevent and treat cattle uterus subinvolution.This is because, the involution of uterus depends on the degradation speed of strength of uterine contraction and uterine cancer cell, and manually get rid of the degradation speed that lochia and above-mentioned injection method can not increase strength of uterine contraction and uterine cancer cell, otherwise, uterine irrigation and perfusion also can increase the burden in uterus, are therefore unfavorable for the involution of uterus.In addition, use antibiotic that pathogen can be made to produce drug resistance, and the quality of milk can be affected because of drug residue, and need heavy dose of minimal inhibitory concentration (5 μ g/g) that just can reach endometrium local organization.Antiseptic then damages endometrium, and can upset the egodefense function in uterus to a certain extent.Therefore, find one prevent and treat the Subinvoluted medicine of cattle uterus safely and effectively or method extremely important.
Summary of the invention
For the problems referred to above existed in the Subinvoluted control of cattle uterus, the invention provides the Subinvoluted Chinese medicine composition of a kind of control cattle uterus.Described Chinese medicine composition not only can prevent the Subinvoluted generation of cattle uterus, and can increase substantially the Subinvoluted cure rate of cattle uterus.The invention also discloses the preparation method of described Chinese medicine composition.
Technical scheme of the present invention is: the Subinvoluted Chinese medicine composition of control cattle uterus, composed of the following components: 10-30 part Herba Leonuri, 10-30 part Radix Angelicae Sinensis, 10-30 part Radix Astragali, 10-30 part Cortex Dictamni, 10-20 part Rhizoma Corydalis, 10-30 part Folium Artemisiae Argyi, 10-30 part Radix Salviae Miltiorrhizae, 10-20 part Rhizoma Chuanxiong, 10-20 part Rhizoma Zingiberis Preparatum, 10-20 part Rhizoma Cyperi (processed with vinegar), 10-20 part Endoconcha Sepiae, 10-20 part Radix Dipsaci, 10-20 part Fructus Forsythiae, 10-20 part Borax, 10-20 part Herba Menthae, 10-20 part Radix Notoginseng, 10-20 part Pseudobulbus Bletillae (Rhizoma Bletillae), 10-20 part Radix Glycyrrhizae.
The preparation method of the Subinvoluted Chinese medicine composition filling agent of control cattle uterus, comprises the following steps:
1. medicament is prepared: take 10-30 part Herba Leonuri, 10-30 part Radix Angelicae Sinensis, 10-30 part Radix Astragali, 10-30 part Cortex Dictamni, 10-20 part Rhizoma Corydalis, 10-30 part Folium Artemisiae Argyi, 10-30 part Radix Salviae Miltiorrhizae, 10-20 part Rhizoma Chuanxiong, 10-20 part Rhizoma Zingiberis Preparatum, 10-20 part Rhizoma Cyperi (processed with vinegar), 10-20 part Endoconcha Sepiae, 10-20 part Radix Dipsaci, 10-20 part Fructus Forsythiae, 10-20 part Borax, 10-20 part Herba Menthae, 10-20 part Radix Notoginseng, 10-20 part Pseudobulbus Bletillae (Rhizoma Bletillae) and 10-20 part Radix Glycyrrhizae respectively.
2. boil medicament: in the medicament that 1. step prepares, add normal-temperature water 2500 ~ 3000ml, soak 30 minutes; After intense fire boils, adopt 45 ~ 55 minutes at a simmer, filtration, obtains medicinal residues and a medicinal liquid is about 100ml; In medicinal residues, add 2000 ~ 2500ml water, adopt 45 ~ 55 minutes at a simmer, filter, obtain secondary medicinal liquid and be about 100ml; A medicinal liquid and the merging of secondary medicinal liquid are obtained medicinal liquid I and is about 200ml.
3. process medicinal liquid: medicinal liquid I centrifugation step 2. obtained, the medicinal liquid II obtained, adopt ethanol precipitation to carry out extracted twice to medicinal liquid II, to remove starch, protein and some polysaccharide impurity, obtain medicinal liquid III; Wherein, it is 50% ~ 60% that first time extracts the concentration of alcohol adopted, and gets supernatant after centrifugal, and then ethanol is reclaimed in distilling under reduced pressure; It is 75% ~ 85% that second time extracts the concentration of alcohol adopted, and gets supernatant after centrifugal, and then ethanol is reclaimed in distilling under reduced pressure.With water, medicinal liquid III is diluted to 300ml, after boiling sterilization, medicinal liquid IV must be clarified, be i.e. the Subinvoluted Chinese medicine composition filling agent of potion treatment cattle uterus.
The using method of the Subinvoluted Chinese medicine composition filling agent of control cattle uterus: cattle is suffered from Baoding, by medicine liquid heating to 35 ~ 40 DEG C, slowly medicinal liquid is poured into deep rectum with enemator or the flexible rubber hose that connects syringe, each consumption is 300ml, once a day, fill with relief trouble cattle stand in low early and high after position and press back, exert duty to alleviate.
Core drug in the Subinvoluted Chinese medicine composition of control cattle uterus of the present invention comprises Herba Leonuri, Radix Angelicae Sinensis, the Radix Astragali, Cortex Dictamni, Rhizoma Corydalis, Folium Artemisiae Argyi and Radix Salviae Miltiorrhizae, wherein: (1) Herba Leonuri can strengthen the contraction of uterine smooth muscle, the discharge of intrauterine foreign body is promoted; Also have bacteriostasis, effectively can alleviate infection; (2) Radix Angelicae Sinensis has the effect of enriching blood and invigorating blood circulation, and also can strengthen the contraction in uterus, play synergism with Herba Leonuri; (3) Radix Astragali is used for improving the immunologic function of body; (4) Cortex Dictamni also can strengthen uterine contraction, and has very strong antibacterial and anti-inflammation functions; (5) Rhizoma Corydalis has promoting blood circulation to restore menstrual flow, the effect of promoting the circulation of QI to relieve pain, energy eliminate pain, and reduce inflammation reaction; (6) Folium Artemisiae Argyi has hemostasis, antibacterial action, can also excited uterus; (7) Radix Salviae Miltiorrhizae can tranquillizing and allaying excitement, has inhibitory action to staphylococcus, vibrio cholera, tubercule bacillus, escherichia coli etc.Important composition of the present invention also comprises some ancillary drugs.Wherein, Rhizoma Chuanxiong can be invigorated blood circulation; Rhizoma Zingiberis Preparatum energy dispelling cold by warming the meridian, hemostasis; Rhizoma Cyperi (processed with vinegar) can be regulated the flow of vital energy resolving depression, can improve the toleration of body, have the effect of the uterus muscle tension force that relaxes; Endoconcha Sepiae energy astringing to arrest bleeding, treating spontaneous emission and leukorrhagia; The invigorating the liver and kidney of Radix Dipsaci energy, bone and muscle strengthening, hemostasis, promotes tissue regeneration; Fructus Forsythiae and Borax all possess the effect of antibacterial anti-inflammatory; Herba Menthae possesses antibacterial, the effect of calming the nerves of easing pain; Radix Notoginseng can be stopped blooding antiinflammatory; Pseudobulbus Bletillae (Rhizoma Bletillae) possesses the effect of hemostatic and antibacterial, antiinflammatory; Radix Glycyrrhizae can antiinflammatory, the immunity of enhancing body.
In addition, the synergism between medicine creates very important impact for the drug effect of important composition.Wherein, Herba Leonuri, Radix Angelicae Sinensis, Cortex Dictamni, Folium Artemisiae Argyi share, and can increase the effect of shrinking uterus each other; Radix Angelicae Sinensis, the Radix Astragali share the immunocompetence can worked in coordination with and increase body; Herba Leonuri, Cortex Dictamni, Rhizoma Corydalis, Radix Salviae Miltiorrhizae share and can strengthen anti-inflammation function; Rhizoma Corydalis, Radix Salviae Miltiorrhizae share and can also strengthen analgesic effect.Rhizoma Chuanxiong, Rhizoma Zingiberis Preparatum can strengthen the effect that Herba Leonuri, Radix Angelicae Sinensis, Cortex Dictamni and Folium Artemisiae Argyi shrink uterus; Rhizoma Cyperi (processed with vinegar), Herba Menthae then can strengthen the analgesic effect of Rhizoma Corydalis, Radix Salviae Miltiorrhizae; Endoconcha Sepiae, Radix Dipsaci, Radix Glycyrrhizae can strengthen the immunologic function of Radix Angelicae Sinensis, the Radix Astragali; Fructus Forsythiae, Borax, Herba Menthae, Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Glycyrrhizae can strengthen the antibacterial and anti-inflammation functions of Herba Leonuri, Cortex Dictamni, Rhizoma Corydalis, Radix Salviae Miltiorrhizae; Rhizoma Zingiberis Preparatum, Endoconcha Sepiae, Radix Dipsaci, Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae) can also work in coordination with hemostasis.
The pharmacological action of various Chinese medicine in the Subinvoluted Chinese medicine composition of control cattle uterus of the present invention:
(1) Herba Leonuri: have blood circulation promoting and blood stasis dispelling function, can prevent and treat vaginal bleeding during pregnancy difficult labour, retention of placenta.All there is excitation in Herba Leonuri decoct and the uterus of contained leonurine to laboratory animal.Leonurine all has inhibitory action to escherichia coli, dysentery bacterium, achorion schoenleinii, Pilus Caprae seu Ovis sample sporidiole bacteria, epidermophyton rubrum and starlike nocadia.
(2) Radix Angelicae Sinensis: having enriches blood invigorates blood circulation, the function of menstruction regulating and pain relieving.The effect of Radix Angelicae Sinensis to uterus has " amphicheirality ", and the excited uterine smooth muscle of its water solublity non-volatile matter mass-energy, contraction is strengthened, and its volatile ingredient then can reduce uterus Rythmic contractions characteristic, makes atony of uterus, but the two is based on the composition of excitement.Certain inhibitory action is all had to dysentery bacterium, Bacillus typhi, escherichia coli, Hemolytic streptococcus.
(3) Radix Astragali: the effect possessing invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus and expelling pus and promoting granulation.The Radix Astragali can be strengthened normal heart and shrink, and has cardiotonic to the heart of exhaustion; Coronary vasodilator and whole body peripheral vessel can be expanded, make blood pressure drops; The secretory pit of the inaccessible skin of energy, suppresses diaphoresis, therefore has anti-hidropoiesis.
(4) Cortex Dictamni: the effect having heat clearing and damp drying, dispelling wind for relieving itching and removing toxic substances.The Cortex Dictamni infusion of volume ratio 1:4 as trichophyton, Trichophyton concentricunm and oidium schoenleinii, all has inhibitory action in various degree to multiple pathomycete.Contained a small amount of dictaminine has excitation to isolated frog heart, and cardiac muscular tension can be made to increase, and output per minute and rich output all increase.Dictaminine has powerful contraction to rabbit and Cavia porcellus uterine smooth muscle.
(5) Rhizoma Corydalis: the function having promoting blood circulation to restore menstrual flow, promoting the circulation of QI to relieve pain, is used for the multiple pain of caused by energy stagnation and blood stasis.Rhizoma Corydalis powder has analgesic to act on, and it is tired as 1/100 of opium, and larger dose tetrahydropalmatine has obvious syngignoscism; Tetrahydropalmatine, Chou prime have slight blood pressure lowering, decreased heart rate effect; Dehydrocory daline has blood pressure lowering, increases CBSF effect, the rat heart muscle necrosis effect that ethanol extract has coronary artery dilating, antagonism isoproterenol causes.
(6) Folium Artemisiae Argyi: possess blood of regulating the flow of vital energy, warming the meridian arteries and veins, effect by cold-damp and only cold type of pain, availablely controls bleeding not during menses, vaginal bleeding during pregnancy etc.; Decoct soup washout and can control eczema scabies, removing dampness to relieve itching.Folium Artemisiae Argyi all has antibacterial action to 10 kinds of Gram-positive aerophils such as anthrax bacillus, Alpha-hemolytic streptococcus, B-Streptococcus hemolyticus, diphtheria corynebacterium, bacillus pseudodiphthericus, lung diplococcoid, staphylococcus aureus, Staphylococcus citreus, white Portugal Portugal coccus, bacillus subtilis in vitro.Folium Artemisiae Argyi has remarkable effect to anticoagulant, and its infusion has the effect promoting blood coagulation.After Folium Artemisiae Argyi charcoal processing, anastalsis strengthens.The decoct of Folium Artemisiae Argyi can excited rabbit isolated uterine, makes it to produce tetanic contraction.Rough extractum also has appreciable stimulating action to guinea pig in vitro uterus.
(7) Radix Salviae Miltiorrhizae: the effect possessing blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, evacuation of pus and pain relieving, may be used for treatment angina pectoris, menoxenia, dysmenorrhea, amenorrhea, metrorrhagia leukorrhagia, mass in the abdomen, gather, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness and malignant boil toxic swelling.Radix Salviae Miltiorrhizae has inhibitory action to staphylococcus, vibrio cholera, tubercule bacillus, escherichia coli, Bacillus typhi, dysentery bacterium and dermatophytes, especially has stronger bacteriostasis to staphylococcus aureus and its Resistant strain.The content of cyclic adenosine monophosphate in platelet (cAMP) can be improved.
(8) Rhizoma Chuanxiong: the effect possessing blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression and wind-expelling pain-stopping, can prevent and treat the stagnant and lump in the abdomen lump of the stasis of blood in puerperal.Rhizoma Chuanxiong has obvious sedation to central nervous system.Rhizoma Chuanxiong decoct makes that the dirty contractive amplitude of isolated frog heart increases, heart rate is slightly slow.The Rabbit Uterus tension force that can make to become pregnant during trace increases, and shrinks and strengthens; A large amount of then instead make metroparalysis and shrink stopping.Rhizoma Chuanxiong has inhibitory action to large intestine, dysentery (Song Nei Shi), distortion, green pus, typhoid fever, Salmonella paratyphi and vibrio cholera etc.Ligustrazine can increase the renal blood flow of anesthetized rabbit, and can diuresis.
(9) Rhizoma Zingiberis Preparatum: the effect possessing dispelling cold by warming the meridian, the hemostasis of warm palace, significantly can shorten the hemorrhage and time that is blood coagulation.
(10) Rhizoma Cyperi (processed with vinegar): possess effect that resolving depression of regulating the flow of vital energy, pain relieving are antiabortive, the toleration of body to pain can be improved.The contraction of 5% Rhizoma Cyperi extractum energy Inhibition test animal isolated uterine, has the effect of the uterus muscle tension force that relaxes.Nutgrass galingale oil has inhibitory action to staphylococcus aureus.The effect that the aqueous solution of Rhizoma Cyperi total alkaloids, glycoside, flavonoid and phenolic compound has heart tonifying and reduces blood pressure.
(11) Endoconcha Sepiae: the effect possessing astringing to arrest bleeding, treating spontaneous emission and leukorrhagia and antacid sore, has and promotes bone defect healing effect.Raw Endoconcha Sepiae is longer than treating spontaneous emission and leukorrhagia and antacid, is usually used in emission, leucorrhea with red and white discharge and stomachache acid regurgitation.Fry Endoconcha Sepiae and be longer than astringing to arrest bleeding, leukorrhagia stopping and sore, can be used for metrostaxis, wound hemorrhage, leucorrhea with red and white discharge and skin infection eczema.
(12) Radix Dipsaci: possess invigorating the liver and kidney, hemostasis and analgesic effect, has the effect of evacuation of pus, hemostasis, analgesia, promotion tissue regeneration to carbuncle and ulcer.
(13) Fructus Forsythiae: the effect possessing heat-clearing and toxic substances removing, dispersing swelling and dissipating binds and dispelling wind and heat pathogens, may be used for treatment carbuncle sore tumefacting virus, sucutaneous nodule scrofula, affection due to external wind and heat, epidemic febrile disease from the beginning of with the puckery pain of pyretic stranguria etc.Fructus Forsythiae has broad-spectrum antibacterial action, has very strong inhibitory action to staphylococcus aureus, Hayes dysentery bacterium, has certain inhibitory action to other pathogenic bacterium, influenza virus, fungus.There is antiinflammatory action.
(14) Borax: external possesses heat-clearing and toxic substances removing, detumescence and antiseptical effect.Borax all has inhibitory action to escherichia coli, bacillus pyocyaneus, anthrax bacillus, shigella flexneri, shigella, Bacillus typhi, Salmonella paratyphi, Bacillus proteus and staphylococcus, Candida albicans, can also suppress diphtheria corynebacterium, cattle type Brucella, Diplococcus pneumoniae, meningococcus and Hemolytic streptococcus etc.Borax still has effect that is anticorrosion and protection skin mucosa.Clinically can rinse ulcer, abscess by this product, particularly mucosa inflammation, as conjunctivitis, gastritis etc., because it is alkalescence, mucosa de-sludging can be made; Oral for urethra sterilization, when particularly urine is acidity, can make it to become alkalescence.
(15) Herba Menthae: the effect with wind-dispelling heat-dissipating, refresh oneself, throat, rash and resolving depression, cures mainly wind heat table disease, have a headache dizzy, conjunctival congestion and swelling pain, pharyngalgia celostomia, and nasal sinusitis, toothache, measles without adequate eruption, urticaria pruritus, hypochondriac pain due to stagnation of liverQI gastral cavity is swollen, scrofula tuberculosis.A small amount of energy stimulating central nervous system for oral administration, makes cutaneous vasodilation, promotes sweat gland secretion, therefore can sweating and heat resolving.Bottleneck throat inflammation can be impelled, mucosa local vasoconstriction, alleviate swelling and pain.External can benumb teleneuron, pain relieving, antipruritic.Decoct has inhibitory action to Bacillus tuberculosis, also has obvious antibacterial action to Bacillus typhi.
(16) Radix Notoginseng: the effect with dissipating blood stasis hemostasis, subduing swelling and relieving pain.Cure mainly spitting of blood, haematemesis, epistaxis, have blood in stool and effect of metrorrhagia.
(17) Pseudobulbus Bletillae (Rhizoma Bletillae): the effect with tonifying the lung, hemostasis, detumescence, granulation promoting and sore, can be used for treatment lung and hinders that hemoptysis, incised wound are hemorrhage, swollen ulcer drug, canker sores, soup fire are burnt and rhagadia manus et pedis.It is active that Pseudobulbus Bletillae (Rhizoma Bletillae) can strengthen platelet factor III, significantly shortens clotting time and thrombinogen formation time, suppresses plasmin enzymatic activity, have anastalsis to local hemorrhage.In addition, Pseudobulbus Bletillae (Rhizoma Bletillae) has inhibitory action to staphylococcus aureus, bacillus subtilis, Bacillus tuberculosis, Candida albicans and Trichophyton.
(18) Radix Glycyrrhizae: the effect with invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough and relieving spasm to stop pain.To food, interior metabolism product, poisoning and diphtheria toxin, diphtherotoxin, tetanus toxin, snake venom etc. have stronger Detoxication to glycyrrhizin in Radix Glycyrrhizae; Radix Glycyrrhizae also has antiinflammatory, antianaphylaxis reagentia, has inhibitory action to dysentery bacterium, anthrax bacillus, Hemolytic streptococcus, Diplococcus pneumoniae, staphylococcus aureus etc.
Beneficial effect of the present invention:
(1) Chinese medicine composition of the present invention effectively combines Herba Leonuri, Radix Angelicae Sinensis, the Radix Astragali, Cortex Dictamni, Rhizoma Corydalis, effect of Folium Artemisiae Argyi and Radix Salviae Miltiorrhizae core drug, and be aided with Rhizoma Chuanxiong, Rhizoma Zingiberis Preparatum, Rhizoma Cyperi (processed with vinegar), Endoconcha Sepiae, Radix Dipsaci, Fructus Forsythiae, Borax, Herba Menthae, Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Glycyrrhizae assist medical material, adopt suitable preparation method, achieve reinforcement uterine myometrium, antibacterial anti-inflammatory, enhancing immunity, the drug effect of hemostatic analgesia and putrefaction-removing granulation-promoting, can effective prevention and therapy cattle uterus subinvolution, reduce uterine infection probability in puerperal, improve and suffer from cattle fertility, promotion cattle-raising is developed in a healthy way and has great importance,
(2) Chinese medicine composition of the present invention efficiently solves treatment subinvolution of uterus Problems existing at present, avoids the problem of drug residue, bacterial drug resistance and the uterus egodefense function upset produced when using hormone and antibiotic therapy;
(3) Chinese medicine composition of the present invention is drawn materials extensive, with low cost; The invention provides best preparation method, obtained filling agent is not only easy to use, and safe and effective simultaneously;
(4) medication of Chinese medicine composition of the present invention is deep rectum perfusion, and administration is more convenient, acts on more direct.Adopt this medicament to treat 18 routine milch cows and 9 routine cattle subinvolution of uterus cases altogether, result is all cured, cure rate 100%, and after curing, reproductive capacity is significantly improved, and particularly early treatment, effect is better.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further.
Embodiment 1:
The Subinvoluted Chinese medicine composition of control cattle uterus, composed of the following components: 20g Herba Leonuri, 20g Radix Angelicae Sinensis, the 20g Radix Astragali, 20g Cortex Dictamni, 15g Rhizoma Corydalis, 20g Folium Artemisiae Argyi, 20g Radix Salviae Miltiorrhizae, 15g Rhizoma Chuanxiong, 15g Rhizoma Zingiberis Preparatum, 15g Rhizoma Cyperi (processed with vinegar), 15g Endoconcha Sepiae, 15g Radix Dipsaci, 15g Fructus Forsythiae, 15g Borax, 15g Herba Menthae, 15g Radix Notoginseng, 15g Pseudobulbus Bletillae (Rhizoma Bletillae), 15g Radix Glycyrrhizae.
The preparation method of the Subinvoluted Chinese medicine composition filling agent of control cattle uterus, comprises the following steps:
1. medicament is prepared: take 10g Herba Leonuri, 20g Radix Angelicae Sinensis, the 30g Radix Astragali, 10g Cortex Dictamni, 15g Rhizoma Corydalis, 30g Folium Artemisiae Argyi, 10g Radix Salviae Miltiorrhizae, 15g Rhizoma Chuanxiong, 20g Rhizoma Zingiberis Preparatum, 10g Rhizoma Cyperi (processed with vinegar), 15g Endoconcha Sepiae, 20g Radix Dipsaci, 10g Fructus Forsythiae, 15g Borax, 20g Herba Menthae, 10g Radix Notoginseng, 15g Pseudobulbus Bletillae (Rhizoma Bletillae), 20g Radix Glycyrrhizae respectively.
2. boil medicament: in the medicament that 1. step prepares, add normal-temperature water 2800ml, soak 30 minutes; After intense fire boils, adopt 50 minutes at a simmer, filtration, obtains medicinal residues and a medicinal liquid is about 100ml; In medicinal residues, add 2200ml water, adopt 50 minutes at a simmer, filter, obtain secondary medicinal liquid and be about 100ml; A medicinal liquid and the merging of secondary medicinal liquid are obtained medicinal liquid I and is about 200ml.
3. process medicinal liquid: medicinal liquid I centrifugation step 2. obtained, the medicinal liquid II obtained, adopt ethanol precipitation to carry out extracted twice to medicinal liquid II, to remove starch, protein and some polysaccharide impurity, obtain medicinal liquid III; Wherein, it is 55% that first time extracts the concentration of alcohol adopted, and gets supernatant after centrifugal, and then ethanol is reclaimed in distilling under reduced pressure; It is 80% that second time extracts the concentration of alcohol adopted, and gets supernatant after centrifugal, and then ethanol is reclaimed in distilling under reduced pressure.With water, medicinal liquid III is diluted to 300ml, after boiling sterilization, medicinal liquid IV must be clarified, be i.e. the Subinvoluted Chinese medicine composition filling agent of potion treatment cattle uterus.
The using method of the Subinvoluted Chinese medicine composition filling agent of control cattle uterus: cattle is suffered from Baoding, by medicine liquid heating to 35 ~ 40 DEG C, slowly medicinal liquid is poured into deep rectum with enemator or the flexible rubber hose that connects syringe, each consumption is 300ml, once a day, fill with relief trouble cattle stand in low early and high after position and press back, exert duty to alleviate.
Treatment case:
From calendar year 2001, having 16 cow heads before and after cattle farm, Heilungkiang, there is subinvolution of uterus in puerperal.Suffer from cattle performance inertia of uterus, the initial stage in puerperal discharges a small amount of lochia.The super inspection of B-finds, during 9 days puerperal, intrauterine also has a large amount of lochia.Gather and suffer from the inspection of Hepar Bovis seu Bubali sample and find, 16 cattle all suffer from fatty liver in various degree, and wherein 4 nose heaviness, 7 cattle moderates, 5 slight.Gather intrauterine specimens and do bacteriology checking discovery, have streptococcus, staphylococcus, escherichia coli, bacillus cereus, corynebacterium, Bacillus proteus, micrococcus luteus and bacillus pyocyaneus not.
During treatment, 16 cattle are divided into matched group (4) and treatment group (12).4 cattle of matched group use estradiol benzoate (20mg) intramuscular injection, oxytocin injection (60 unit) again after half an hour, 6 hr later injection chlorine gas system 0.4mg, continuous injection 3 days, the average time that result suffers from the most lochia of beefsteak is 14.5 days, involution of uterus time average 45.3 days, then pregnancy rate is 80% (4/5).The above-mentioned Chinese medicine composition filling agent of 12 cattle for the treatment of group is treated, and every day 1 dose (300ml), perfusion was to deep rectum.After average use 3.5 doses, whole beefsteak is lochia to the greatest extent, and the time average that lochia drains is 12.8 days, and the time average that the involution of uterus completes is 39.6 days, cure rate 100%, then pregnancy rate 91.6%.
The criterion that the involution of uterus completes: super identical to angle tip diameter from base portion with empty angle with electronic caliper mensuration uterus pregnant horn with B-, without gas or liquid in cavity of uterus, endometrium is recovered completely.
Embodiment 2:
As different from Example 1, the Subinvoluted Chinese medicine composition of control cattle uterus, composed of the following components: 20g Herba Leonuri, 30g Radix Angelicae Sinensis, the 10g Radix Astragali, 20g Cortex Dictamni, 20g Rhizoma Corydalis, 10g Folium Artemisiae Argyi, 20g Radix Salviae Miltiorrhizae, 20g Rhizoma Chuanxiong, 10g Rhizoma Zingiberis Preparatum, 15g Rhizoma Cyperi (processed with vinegar), 20g Endoconcha Sepiae, 10g Radix Dipsaci, 15g Fructus Forsythiae, 20g Borax, 10g Herba Menthae, 15g Radix Notoginseng, 20g Pseudobulbus Bletillae (Rhizoma Bletillae), 10g Radix Glycyrrhizae.
The preparation method of the Subinvoluted Chinese medicine composition filling agent of control cattle uterus, comprises the following steps:
1. medicament is prepared: 20g Herba Leonuri, 30g Radix Angelicae Sinensis, the 10g Radix Astragali, 20g Cortex Dictamni, 20g Rhizoma Corydalis, 10g Folium Artemisiae Argyi, 20g Radix Salviae Miltiorrhizae, 20g Rhizoma Chuanxiong, 10g Rhizoma Zingiberis Preparatum, 15g Rhizoma Cyperi (processed with vinegar), 20g Endoconcha Sepiae, 10g Radix Dipsaci, 15g Fructus Forsythiae, 20g Borax, 10g Herba Menthae, 15g Radix Notoginseng, 20g Pseudobulbus Bletillae (Rhizoma Bletillae), 10g Radix Glycyrrhizae.
2. boil medicament: in the medicament that 1. step prepares, add normal-temperature water 3000ml, soak 30 minutes; After intense fire boils, adopt 55 minutes at a simmer, filtration, obtains medicinal residues and a medicinal liquid is about 100ml; In medicinal residues, add 2000 ~ 2500ml water, adopt 45 minutes at a simmer, filter, obtain secondary medicinal liquid and be about 100ml; A medicinal liquid and the merging of secondary medicinal liquid are obtained medicinal liquid I and is about 200ml.
3. process medicinal liquid: medicinal liquid I centrifugation step 2. obtained, the medicinal liquid II obtained, adopt ethanol precipitation to carry out extracted twice to medicinal liquid II, to remove starch, protein and some polysaccharide impurity, obtain medicinal liquid III; Wherein, it is 60% that first time extracts the concentration of alcohol adopted, and gets supernatant after centrifugal, and then ethanol is reclaimed in distilling under reduced pressure; It is 75% that second time extracts the concentration of alcohol adopted, and gets supernatant after centrifugal, and then ethanol is reclaimed in distilling under reduced pressure.With water, medicinal liquid III is diluted to 300ml, after boiling sterilization, medicinal liquid IV must be clarified, be i.e. the Subinvoluted Chinese medicine composition filling agent of potion treatment cattle uterus.
Treatment case:
2002, in certain cattle cultivation base for Bovine Embryo Transfer, because dairy calf is relatively large, therefore easily there is subinvolution of uterus in the cattle of replace-conceive dairy calf puerperal.After finding 9 trouble cattle, adopt above-mentioned Chinese medicine composition filling agent to treat, every day 1 dose (300ml), perfusion was to deep rectum.Found that, average irrigation 3.2 doses, the time average that trouble cattle lochia drains is 12.4 days, and the time average that the involution of uterus completes is 37.6 days, cure rate 100%.
Embodiment 3:
As different from Example 1, the Subinvoluted Chinese medicine composition of control cattle uterus, composed of the following components: 30g Herba Leonuri, 10g Radix Angelicae Sinensis, the 20g Radix Astragali, 30g Cortex Dictamni, 10g Rhizoma Corydalis, 20g Folium Artemisiae Argyi, 30g Radix Salviae Miltiorrhizae, 10g Rhizoma Chuanxiong, 15g Rhizoma Zingiberis Preparatum, 20g Rhizoma Cyperi (processed with vinegar), 10g Endoconcha Sepiae, 15g Radix Dipsaci, 20g Fructus Forsythiae, 10g Borax, 15g Herba Menthae, 20g Radix Notoginseng, 10g Pseudobulbus Bletillae (Rhizoma Bletillae), 15g Radix Glycyrrhizae.
The preparation method of the Subinvoluted Chinese medicine composition filling agent of control cattle uterus, comprises the following steps:
1. medicament is prepared: take 10g Herba Leonuri, 20g Radix Angelicae Sinensis, the 30g Radix Astragali, 10g Cortex Dictamni, 15g Rhizoma Corydalis, 30g Folium Artemisiae Argyi, 10g Radix Salviae Miltiorrhizae, 15g Rhizoma Chuanxiong, 20g Rhizoma Zingiberis Preparatum, 10g Rhizoma Cyperi (processed with vinegar), 15g Endoconcha Sepiae, 20g Radix Dipsaci, 10g Fructus Forsythiae, 15g Borax, 20g Herba Menthae, 10g Radix Notoginseng, 15g Pseudobulbus Bletillae (Rhizoma Bletillae), 20g Radix Glycyrrhizae respectively.
2. boil medicament: in the medicament that 1. step prepares, add normal-temperature water 2800ml, soak 30 minutes; After intense fire boils, adopt 50 minutes at a simmer, filtration, obtains medicinal residues and a medicinal liquid is about 100ml; In medicinal residues, add 2200ml water, adopt 50 minutes at a simmer, filter, obtain secondary medicinal liquid and be about 100ml; A medicinal liquid and the merging of secondary medicinal liquid are obtained medicinal liquid I and is about 200ml.
3. process medicinal liquid: medicinal liquid I centrifugation step 2. obtained, the medicinal liquid II obtained, adopt ethanol precipitation to carry out extracted twice to medicinal liquid II, to remove starch, protein and some polysaccharide impurity, obtain medicinal liquid III; Wherein, it is 55% that first time extracts the concentration of alcohol adopted, and gets supernatant after centrifugal, and then ethanol is reclaimed in distilling under reduced pressure; It is 80% that second time extracts the concentration of alcohol adopted, and gets supernatant after centrifugal, and then ethanol is reclaimed in distilling under reduced pressure.With water, medicinal liquid III is diluted to 300ml, after boiling sterilization, medicinal liquid IV must be clarified, be i.e. the Subinvoluted Chinese medicine composition filling agent of potion treatment cattle uterus.
Treatment case: the cow head generation placenta retention that household dairy cow breeding Zou raises.This cattle of main suit calving 2 days, gives birth to twins calf, after this spiritual depressed, and the back of a bow, often does posture of urinating.Find on inspection, suffer from cattle spirit depressed, body temperature 39.5 DEG C, 63 beats/min, pulse, breathe 34 beats/min.Examination per vagina finds, part retained afterbirth is in intravaginal, and atresia of cervix, refers to by two reluctantly, be diagnosed as placenta retention.While vein fluid infusion, get the treatment of above-mentioned Chinese medicine composition filling agent, be used in conjunction 2 doses, afterbirth is discharged.After this find that this cattle uterus shrinks unable, throw 2 doses again subsequently, the super inspection of B-finds, suffer from cattle and drained lochia 13.0 days time, it is 39 days that uterus completes the restoration of old ways time.
Embodiment 4:
As different from Example 1, the Subinvoluted Chinese medicine composition of control cattle uterus, composed of the following components: 10g Herba Leonuri, 20g Radix Angelicae Sinensis, the 30g Radix Astragali, 10g Cortex Dictamni, 15g Rhizoma Corydalis, 30g Folium Artemisiae Argyi, 10g Radix Salviae Miltiorrhizae, 15g Rhizoma Chuanxiong, 20g Rhizoma Zingiberis Preparatum, 10g Rhizoma Cyperi (processed with vinegar), 15g Endoconcha Sepiae, 20g Radix Dipsaci, 10g Fructus Forsythiae, 15g Borax, 20g Herba Menthae, 10g Radix Notoginseng, 15g Pseudobulbus Bletillae (Rhizoma Bletillae), 20g Radix Glycyrrhizae.
The preparation method of the Subinvoluted Chinese medicine composition filling agent of control cattle uterus, comprises the following steps:
1. medicament is prepared: take 10g Herba Leonuri, 20g Radix Angelicae Sinensis, the 30g Radix Astragali, 10g Cortex Dictamni, 15g Rhizoma Corydalis, 30g Folium Artemisiae Argyi, 10g Radix Salviae Miltiorrhizae, 15g Rhizoma Chuanxiong, 20g Rhizoma Zingiberis Preparatum, 10g Rhizoma Cyperi (processed with vinegar), 15g Endoconcha Sepiae, 20g Radix Dipsaci, 10g Fructus Forsythiae, 15g Borax, 20g Herba Menthae, 10g Radix Notoginseng, 15g Pseudobulbus Bletillae (Rhizoma Bletillae), 20g Radix Glycyrrhizae respectively.
2. boil medicament: in the medicament that 1. step prepares, add normal-temperature water 2500ml, soak 30 minutes; After intense fire boils, adopt 45 minutes at a simmer, filtration, obtains medicinal residues and a medicinal liquid is about 100ml; In medicinal residues, add 2500ml water, adopt 55 minutes at a simmer, filter, obtain secondary medicinal liquid and be about 100ml; A medicinal liquid and the merging of secondary medicinal liquid are obtained medicinal liquid I and is about 200ml.
3. process medicinal liquid: medicinal liquid I centrifugation step 2. obtained, the medicinal liquid II obtained, adopt ethanol precipitation to carry out extracted twice to medicinal liquid II, to remove starch, protein and some polysaccharide impurity, obtain medicinal liquid III; Wherein, it is 50% that first time extracts the concentration of alcohol adopted, and gets supernatant after centrifugal, and then ethanol is reclaimed in distilling under reduced pressure; It is 85% that second time extracts the concentration of alcohol adopted, and gets supernatant after centrifugal, and then ethanol is reclaimed in distilling under reduced pressure.With water, medicinal liquid III is diluted to 300ml, after boiling sterilization, medicinal liquid IV must be clarified, be i.e. the Subinvoluted Chinese medicine composition filling agent of potion treatment cattle uterus.
For the curative effect of certain Chinese medicine composition of the present invention, contrast experiment has been carried out in application, according to General Symptoms and the local symptom of suffering from cattle, determine the trouble cattle 25 of subinvolution of uterus, and be divided into 5 groups, I group is matched group, II group is treatment group, III group is prevention group, IV group is chlorine gas system group for estrogen group and V group, often organizes 5.Wherein, matched group only does examination per rectum.Treatment group used above-mentioned Chinese medicine composition filling agent to treat when the 9th day puerperal, every day potion, the perfusion of every agent 300ml internal rectum, is used in conjunction 3 days.Prevention group used above-mentioned Chinese medicine composition filling agent to treat when the 4th day puerperal, the same treatment group of method.Estrogen group used the intramuscular injection of 20mg estradiol benzoate when the 4th day puerperal, injected 60 U oxytocin again after half an hour, once a day, and injection 3 days continuously.Chlorine gas system group is at injection in the 4th day puerperal chlorine gas system 0.4mg, once a day, and injection 3 days continuously.
Uterine bacteria detects: the 12nd day puerperal put into disinfecting silk or cotton swab in the sampler of film biopsy in uterus recess, and aseptic collection cornua uteri crotch sample, sample is cultivated after treatment and done count of bacteria.
The B-super monitoring involution of uterus: the 4th day puerperal started, in medication process, every day monitors amount and the involution of uterus situation of intrauterine lochia with B ultrasonic.After medication terminates, monitor 2 times weekly, the involution of uterus, close to when completing, is monitored once every other day.Found that, compare with matched group and hormone group (comprising estrogen group and chlorine gas system group), treatment group and prevention group all complete the involution of uterus within the scope of normal time.Meanwhile, the uterine bacteria number for the treatment of group and prevention group is less, and lochia drains time, puerperal, and ovulation period and puerperal, breeding time was shorter first first.In 5 groups of tested cattle, every monitoring index optimum (table 1) of prevention group.
Table 1 Chinese medicine composition prevents and treats the infull contrast and experiment statistics of Uterine And Cervical Involution In The Cow in advance
Table 2 Chinese medicine composition of the present invention prevents and treats milk (Huang) cattle uterus subinvolution result statistics in advance
Claims (4)
1. prevent and treat the Subinvoluted Chinese medicine composition of cattle uterus, it is characterized in that: count by weight, composed of the following components: 10-30 part Herba Leonuri, 10-30 part Radix Angelicae Sinensis, 10-30 part Radix Astragali, 10-30 part Cortex Dictamni, 10-20 part Rhizoma Corydalis, 10-30 part Folium Artemisiae Argyi, 10-30 part Radix Salviae Miltiorrhizae, 10-20 part Rhizoma Chuanxiong, 10-20 part Rhizoma Zingiberis Preparatum, 10-20 part Rhizoma Cyperi (processed with vinegar), 10-20 part Endoconcha Sepiae, 10-20 part Radix Dipsaci, 10-20 part Fructus Forsythiae, 10-20 part Borax, 10-20 part Herba Menthae, 10-20 part Radix Notoginseng, 10-20 part Pseudobulbus Bletillae (Rhizoma Bletillae), 10-20 part Radix Glycyrrhizae.
2. prevent and treat the preparation method of the Subinvoluted Chinese medicine composition filling agent of cattle uterus, it is characterized in that: comprise the following steps:
1. medicament is prepared: take 10-30 part Herba Leonuri, 10-30 part Radix Angelicae Sinensis, 10-30 part Radix Astragali, 10-30 part Cortex Dictamni, 10-20 part Rhizoma Corydalis, 10-30 part Folium Artemisiae Argyi, 10-30 part Radix Salviae Miltiorrhizae, 10-20 part Rhizoma Chuanxiong, 10-20 part Rhizoma Zingiberis Preparatum, 10-20 part Rhizoma Cyperi (processed with vinegar), 10-20 part Endoconcha Sepiae, 10-20 part Radix Dipsaci, 10-20 part Fructus Forsythiae, 10-20 part Borax, 10-20 part Herba Menthae, 10-20 part Radix Notoginseng, 10-20 part Pseudobulbus Bletillae (Rhizoma Bletillae) and 10-20 part Radix Glycyrrhizae respectively;
2. boil medicament: in the medicament that 1. step prepares, add normal-temperature water 2500 ~ 3000ml, soak 30 minutes; After intense fire boils, adopt 45 ~ 55 minutes at a simmer, filter, obtain medicinal residues and a medicinal liquid; In medicinal residues, add 2000 ~ 2500ml water, adopt 45 ~ 55 minutes at a simmer, filter, obtain secondary medicinal liquid; A medicinal liquid and secondary medicinal liquid are merged and obtains medicinal liquid I;
3. medicinal liquid is processed: medicinal liquid I centrifugation step 2. obtained, the medicinal liquid II obtained, ethanol precipitation is adopted to carry out double extraction to medicinal liquid II, it is 50% ~ 60% (volumetric concentration) that first time extracts the concentration of alcohol adopted, it is 75% ~ 85% (volumetric concentration) that second time extracts the concentration of alcohol adopted, and obtains medicinal liquid III; With water, medicinal liquid III is diluted to 300ml, after boiling sterilization, obtains clarification medicinal liquid IV, i.e. the Subinvoluted Chinese medicine composition filling agent of potion treatment cattle uterus.
3. preventing and treating the using method of the Subinvoluted Chinese medicine composition filling agent of cattle uterus, it is characterized in that: comprise the following steps: cattle is suffered from (1) Baoding, is that the medicine liquid irrigation of 35 ~ 40 DEG C injects deep rectum by temperature; Each consumption is 300ml, once a day; (2) make trouble cattle keep low early and high after posture after pouring into medicament and press back 5 ~ 10min.
4. the using method of the Subinvoluted Chinese medicine composition filling agent of control cattle uterus according to claim 4, is characterized in that: adopt the flexible rubber hose of enemator or connection syringe slowly medicinal liquid to be poured into rectum in described step (1).
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| CN106177447A (en) * | 2016-09-09 | 2016-12-07 | 马玉珍 | A kind of treat the cow uteri the most complete Chinese medicine composition of retraction |
| CN110050888A (en) * | 2019-03-12 | 2019-07-26 | 河北科星药业有限公司 | Nutrition recuperating agent suitable for fresh cow and preparation method thereof, application |
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| KR20090010384A (en) * | 2007-07-23 | 2009-01-30 | 김재욱 | Composition of herb medicine for female edema and method for preparing the composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106177447A (en) * | 2016-09-09 | 2016-12-07 | 马玉珍 | A kind of treat the cow uteri the most complete Chinese medicine composition of retraction |
| CN110050888A (en) * | 2019-03-12 | 2019-07-26 | 河北科星药业有限公司 | Nutrition recuperating agent suitable for fresh cow and preparation method thereof, application |
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