CN104873593A - Medicine composite preventing cow fetal membrane from retaining and preparation method thereof - Google Patents
Medicine composite preventing cow fetal membrane from retaining and preparation method thereof Download PDFInfo
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- CN104873593A CN104873593A CN201510350213.1A CN201510350213A CN104873593A CN 104873593 A CN104873593 A CN 104873593A CN 201510350213 A CN201510350213 A CN 201510350213A CN 104873593 A CN104873593 A CN 104873593A
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Abstract
The invention discloses a medicine composite preventing a cow fetal membrane from retaining and a preparation method thereof, and belongs to the field of veterinary medicine. The medicine composite is composed of chaff flower roots, cluster mallow fruits, motherwort herbs, cinnamon, astragali radix, plantain seeds, sesame oil, safflowers, caulis spatholobi, fringed pink, akebia stems, Chinese angelica, codonopsis pilosula, licorice roots, semen persicae, rhizoma chuanxiong, red halloysite and calcium lactate. According to the preparation method, the medicinal materials are cleaned, weighed and smashed into coarse powder, water which is 1-4 times the medicinal materials is added for extraction, concentration is performed, extract is obtained after drying, and the red halloysite and the calcium lactate are evenly stirred. The medicine composite improves the contractility of the cow uterus, promotes discharging of the fetal membrane, shortens the time for excreting the lochia, and improves propagation performance.
Description
Technical field
The invention belongs to field of veterinary, be specifically related to a kind ofly prevent and treat pharmaceutical composition of milch cow placenta retention and preparation method thereof, the present invention is used for prevention and therapy milch cow placenta retention symptom, effectively can improve the reproductive performance of milch cow.
Background technology
Milch cow placenta retention makes again milk cattle placenta stagnate.After referring to cow output tire calf, within a certain period of time, afterbirth can not come off and be stranded in intrauterine.The placenta retention of milch cow is divided into two kinds of situations, wherein more whole placenta retention case (some afterbirth expose hang over outside vaginal orifice), and this situation ratio is easier to make diagnosis; The second situation is part placenta retention, because this part of afterbirth undischarged remains in intrauterine.The milch cow of placenta retention there will be lochia efflux time and extends; include corrupt afterbirth fragment, hogback, exerts duty again and again; there is systemic toxicity profiles phenomenon after absorbing in spoilage product, body temperature risings, inappetence, gastrointestinal hypofunction, ruminates and reduce or endometrium inflammation etc.
The cause of disease of milch cow placenta retention:
One, puerperal inertia of uterus
1, the feedstuff that life-time service is single or quality is very poor, daily ration mineral, vitamin deficiency and deficiency;
2, dry breast phase quantity of motion is not enough, and light application time is short;
3, bad, the concentrate of becoming thin or excessively feed of dairy cow nutrition makes body overfertilization etc. all can cause inertia of uterus in puerperal.
Two, the afterbirth adhesion caused by inflammation of uterus: as fungal infection, Virus entry, endometritis etc., caused Placenta Hominis and endometrium inflammation cause soft tissue hyperplasia to cause fetal placenta and placenta materna to stick together then.
Prevention and controls at present about milch cow placenta retention mainly uses antibiotic, but the side effect that antibiotic brings is also following, and antibiotic remains in a large number, there is the off-drug period, has carried out huge economic loss to cultivation industrial belt.Pharmaceutical composition of the present invention has it natural, safety, no drug residue, without the medicine phase, and can effective prevention and therapy milch cow placenta retention symptom.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition of control milch cow placenta retention of natural, efficient, no drug residue, to improve the fertility performance of milch cow.
The present invention is achieved in that
A kind of pharmaceutical composition preventing and treating milch cow placenta retention is prepared from by the raw material of following parts by weight: Radix Achyranthis Bidentatae 5-15 part, Semen Abutili 1-10 part, Herba Leonuri 5-15 part, Cortex Cinnamomi 1-10 part, Radix Astragali 1-10 part, Semen Plantaginis 5-15 part, Oleum sesami 1-5 part, Flos Carthami 1-5 part, Caulis Spatholobi 1-10 part, Herba Dianthi 1-10 part, Caulis Akebiae 1-5 part, Radix Angelicae Sinensis 1-10 part, Radix Codonopsis 1-10 part, Radix Glycyrrhizae 1-5 part, Semen Persicae 1-10 part, Rhizoma Chuanxiong 1-10 part, Halloysitum Rubrum 1-10 part, calcium lactate 1-10 part.
The present invention is realized by following technical method:
A kind of pharmaceutical composition preventing and treating milch cow placenta retention is prepared from by the raw material of following parts by weight: Radix Achyranthis Bidentatae 8-12 part, Semen Abutili 2-8 part, Herba Leonuri 8-12 part, Cortex Cinnamomi 2-8 part, Radix Astragali 2-8 part, Semen Plantaginis 8-12 part, Oleum sesami 1-4 part, Flos Carthami 1-4 part, Caulis Spatholobi 2-8 part, Herba Dianthi 2-8 part, Caulis Akebiae 1-4 part, Radix Angelicae Sinensis 2-8 part, Radix Codonopsis 2-8 part, Radix Glycyrrhizae 1-4 part, Semen Persicae 2-8 part, Rhizoma Chuanxiong 2-8 part, Halloysitum Rubrum 2-8 part, calcium lactate 2-8 part.
The present invention is realized by following technical method:
A kind of pharmaceutical composition preventing and treating milch cow placenta retention is prepared from by the raw material of following parts by weight: Radix Achyranthis Bidentatae 10 parts, Semen Abutili 5 parts, Herba Leonuri 10 parts, Cortex Cinnamomi 5 parts, the Radix Astragali 5 parts, Semen Plantaginis 10 parts, Oleum sesami 3 parts, 3 parts, Flos Carthami, Caulis Spatholobi 5 parts, Herba Dianthi 5 parts, Caulis Akebiae 2 parts, Radix Angelicae Sinensis 5 parts, Radix Codonopsis 6 parts, 2 parts, Radix Glycyrrhizae, 5 parts, Semen Persicae, Rhizoma Chuanxiong 4 parts, Halloysitum Rubrum 5 parts, calcium lactate 5 parts.
A kind of pharmaceutical composition preventing and treating milch cow placenta retention is prepared from by following methods:
(1) Radix Achyranthis Bidentatae, Semen Abutili, Herba Leonuri, Cortex Cinnamomi, the Radix Astragali, Semen Plantaginis, Oleum sesami, Flos Carthami, Caulis Spatholobi, Herba Dianthi, Caulis Akebiae, Radix Angelicae Sinensis, Radix Codonopsis, Radix Glycyrrhizae, Semen Persicae, Ligusticum chuanxiong Hort are cleaned, dry, weighed, pulverizing medicinal materials becomes coarse powder;
(2) medicinal material coarse powder is added 1-5 water doubly, be heated to boiling, make it the 1-4h that seethes with excitement, each extraction 1-4 time, be back to extractum, vacuum drying powdered obtains extract;
(3) Halloysitum Rubrum, calcium lactate are mixed with above extract with proper proportion, stir 10-20min.
A kind of pharmaceutical composition preventing and treating milch cow placenta retention is characterized in that its adjuvant adds wherein one or more such as silicon dioxide, dextrin, sucrose.
Beneficial effect of the present invention is as follows:
1, the present invention uses traditional tcm theory to combine with present production technology, makes that the effective ingredient of product is maximized to be extracted.
2, the present invention can not only prevent and treat milch cow placenta retention, and effect of benefiting qi and nourishing blood.
3, no drug residue of the present invention, can ensure food safety.
Detailed description of the invention
Below by embodiment, the present invention is elaborated, therefore do not limit the present invention among described scope of embodiments.
Embodiment 1
Radix Achyranthis Bidentatae 5 parts, Semen Abutili 1 part, Herba Leonuri 5 parts, Cortex Cinnamomi 1 part, the Radix Astragali 1 part, Semen Plantaginis 5 parts, Oleum sesami 1 part, 1 part, Flos Carthami, Caulis Spatholobi 1 part, Herba Dianthi 1 part, Caulis Akebiae 1 part, Radix Angelicae Sinensis 1 part, Radix Codonopsis 1 part, 1 part, Radix Glycyrrhizae, 1 part, Semen Persicae, Rhizoma Chuanxiong 1 part, Halloysitum Rubrum 1 part, calcium lactate 1 part.
Preparation method is as follows:
(1) Radix Achyranthis Bidentatae, Semen Abutili, Herba Leonuri, Cortex Cinnamomi, the Radix Astragali, Semen Plantaginis, Oleum sesami, Flos Carthami, Caulis Spatholobi, Herba Dianthi, Caulis Akebiae, Radix Angelicae Sinensis, Radix Codonopsis, Radix Glycyrrhizae, Semen Persicae, Ligusticum chuanxiong Hort are cleaned, dry, weighed, pulverizing medicinal materials becomes coarse powder;
(2) medicinal material coarse powder is added the water of 1 times, be heated to boiling, make it the 1h that seethes with excitement, each extraction 1 time, be back to extractum, vacuum drying powdered obtains extract;
(3) Halloysitum Rubrum, calcium lactate are mixed with above extract with proper proportion, stir 10min, add the adjuvants such as sucrose and make product.
Embodiment 2
Radix Achyranthis Bidentatae 10 parts, Semen Abutili 5 parts, Herba Leonuri 10 parts, Cortex Cinnamomi 5 parts, the Radix Astragali 5 parts, Semen Plantaginis 10 parts, Oleum sesami 2 parts, 3 parts, Flos Carthami, Caulis Spatholobi 5 parts, Herba Dianthi 5 parts, Caulis Akebiae 3 parts, Radix Angelicae Sinensis 5 parts, Radix Codonopsis 5 parts, 2 parts, Radix Glycyrrhizae, 5 parts, Semen Persicae, Rhizoma Chuanxiong 5 parts, Halloysitum Rubrum 5 parts, calcium lactate 5 parts.
Preparation method is as follows:
(1) Radix Achyranthis Bidentatae, Semen Abutili, Herba Leonuri, Cortex Cinnamomi, the Radix Astragali, Semen Plantaginis, Oleum sesami, Flos Carthami, Caulis Spatholobi, Herba Dianthi, Caulis Akebiae, Radix Angelicae Sinensis, Radix Codonopsis, Radix Glycyrrhizae, Semen Persicae, Ligusticum chuanxiong Hort are cleaned, dry, weighed, pulverizing medicinal materials becomes coarse powder;
(2) medicinal material coarse powder is added the water of 3 times, be heated to boiling, make it the 3h that seethes with excitement, each extraction 3 times, be back to extractum, vacuum drying powdered obtains extract;
(3) Halloysitum Rubrum, calcium lactate are mixed with above extract with proper proportion, stir 15min, add the adjuvants such as sucrose and make product.
Embodiment 3
Radix Achyranthis Bidentatae 15 parts, Semen Abutili 10 parts, Herba Leonuri 15 parts, Cortex Cinnamomi 10 parts, the Radix Astragali 10 parts, Semen Plantaginis 15 parts, Oleum sesami 5 parts, 5 parts, Flos Carthami, Caulis Spatholobi 10 parts, Herba Dianthi 10 parts, Caulis Akebiae 5 parts, Radix Angelicae Sinensis 10 parts, Radix Codonopsis 10 parts, 5 parts, Radix Glycyrrhizae, 10 parts, Semen Persicae, Rhizoma Chuanxiong 10 parts, Halloysitum Rubrum 10 parts, calcium lactate 10 parts.
Preparation method is as follows:
(1) Radix Achyranthis Bidentatae, Semen Abutili, Herba Leonuri, Cortex Cinnamomi, the Radix Astragali, Semen Plantaginis, Oleum sesami, Flos Carthami, Caulis Spatholobi, Herba Dianthi, Caulis Akebiae, Radix Angelicae Sinensis, Radix Codonopsis, Radix Glycyrrhizae, Semen Persicae, Ligusticum chuanxiong Hort are cleaned, dry, weighed, pulverizing medicinal materials becomes coarse powder;
(2) medicinal material coarse powder is added the water of 5 times, be heated to boiling, make it the 4h that seethes with excitement, each extraction 4 times, be back to extractum, vacuum drying powdered obtains extract;
(3) Halloysitum Rubrum, calcium lactate are mixed with above extract with proper proportion, stir 20min, add the adjuvants such as sucrose and make product.
Test example
The prophylactic tria of milch cow placenta retention
Select to also have five days just before giving birth milch cows 50, be divided into 2 groups, often organize each 25, one group of feedstuff of feeding containing medicine of the present invention, another group is control group fed chow diet, feeds five days.Afterbirth situation after the calving of observation milch cow.
Table 1 pharmaceutical composition prevention of the present invention group and matched group are to the prevention situation of milch cow placenta retention
Result of the test: from test, the case of matched group milch cow placenta retention reaches 32%, and milch cow placenta retention case of the present invention is 0, and compared with matched group, medicine of the present invention effectively can prevent the generation of milch cow placenta retention case.
The therapeutic test of milch cow placenta retention
Select the milch cow case 50 of milch cow placenta retention, be divided into 2 groups, often organize each 25, the medicine of medicine group gavages with after the dilution of appropriate water, and blank group does not add any medicine.Observe milk cattle placenta incidence.
Table 2 medicine composite for curing group of the present invention and matched group are to the treatment situation of milch cow placenta retention
Result of the test: from test, the case of matched group milch cow placenta retention reaches 100%, and milch cow placenta retention case of the present invention is 0, and compared with matched group, medicine of the present invention effectively can treat the generation of milch cow placenta retention case.
Claims (7)
1. prevent and treat a pharmaceutical composition for milch cow placenta retention, be made up of following raw material: Radix Achyranthis Bidentatae (Achyranthes bidentata B1.), Semen Abutili (Malva verticillata L), Herba Leonuri (Leonurus japonicus Houtt.), Cortex Cinnamomi (Cinnamomum cassia Presl), the Radix Astragali (Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao, Astragalusmembranaceus (Fisch.) Bge.), Semen Plantaginis (Plantago asiatica L., Plantago depressssa Willd.), Oleum sesami (Pogostemoncablin (Blarico) Benth., Illicium verum Hook.f.), Flos Carthami (Carthamus tinctorius L.), Caulis Spatholobi (Spatholobussuberectus Dunn), Herba Dianthi (Dianthus superbus L., Dianthus chinensis L.), Caulis Akebiae (Akebia quinata (Thunb.) Decne., Akebia trifoliata (Thunb.) Koidz., Akebia trifoliate (Thunb.) Koidz.var.australis (Diels) Rehd.), Radix Angelicae Sinensis (Angelica sinensis (Oliv.) Diels.), Radix Codonopsis (Codonopsis pilosula (Franch.) Nannf., Codonopsis pilosula Nannf.var.modesta (Nannf.) L.T.Shen, Codonopsis tangshen Oliv.), Radix Glycyrrhizae (Glycyrrhiza uralensis Fisch., Glycyrrhizainflata Bat., Glycyrrhiza glabra L.), Semen Persicae (Prunus persica (L.) Batsch, Prusua davidiana (Carr.) Franch.), Rhizoma Chuanxiong (Ligusticum chuanxiong Hort.), Halloysitum Rubrum (Halloysitum Rubrum), calcium lactate (Calcium Lactate).
2. a kind of pharmaceutical composition preventing and treating milch cow placenta retention according to claim 1 is prepared from by the raw material of following parts by weight: Radix Achyranthis Bidentatae 5-15 part, Semen Abutili 1-10 part, Herba Leonuri 5-15 part, Cortex Cinnamomi 1-10 part, Radix Astragali 1-10 part, Semen Plantaginis 5-15 part, Oleum sesami 1-5 part, Flos Carthami 1-5 part, Caulis Spatholobi 1-10 part, Herba Dianthi 1-10 part, Caulis Akebiae 1-5 part, Radix Angelicae Sinensis 1-10 part, Radix Codonopsis 1-10 part, Radix Glycyrrhizae 1-5 part, Semen Persicae 1-10 part, Rhizoma Chuanxiong 1-10 part, Halloysitum Rubrum 1-10 part, calcium lactate 1-10 part.
3. a kind of pharmaceutical composition preventing and treating milch cow placenta retention according to claim 2 is prepared from by the raw material of following parts by weight: Radix Achyranthis Bidentatae 8-12 part, Semen Abutili 2-8 part, Herba Leonuri 8-12 part, Cortex Cinnamomi 2-8 part, Radix Astragali 2-8 part, Semen Plantaginis 8-12 part, Oleum sesami 1-4 part, Flos Carthami 1-4 part, Caulis Spatholobi 2-8 part, Herba Dianthi 2-8 part, Caulis Akebiae 1-4 part, Radix Angelicae Sinensis 2-8 part, Radix Codonopsis 2-8 part, Radix Glycyrrhizae 1-4 part, Semen Persicae 2-8 part, Rhizoma Chuanxiong 2-8 part, Halloysitum Rubrum 2-8 part, calcium lactate 2-8 part.
4. a kind of pharmaceutical composition preventing and treating milch cow placenta retention according to claim 3 is prepared from by the raw material of following parts by weight: Radix Achyranthis Bidentatae 10 parts, Semen Abutili 5 parts, Herba Leonuri 10 parts, Cortex Cinnamomi 5 parts, the Radix Astragali 5 parts, Semen Plantaginis 10 parts, Oleum sesami 3 parts, 3 parts, Flos Carthami, Caulis Spatholobi 5 parts, Herba Dianthi 5 parts, Caulis Akebiae 2 parts, Radix Angelicae Sinensis 5 parts, Radix Codonopsis 6 parts, 2 parts, Radix Glycyrrhizae, 5 parts, Semen Persicae, Rhizoma Chuanxiong 4 parts, Halloysitum Rubrum 5 parts, calcium lactate 5 parts.
5. a kind of pharmaceutical composition preventing and treating milch cow placenta retention according to claim 2 is prepared from by following preparation method:
(1) Radix Achyranthis Bidentatae, Semen Abutili, Herba Leonuri, Cortex Cinnamomi, the Radix Astragali, Semen Plantaginis, Oleum sesami, Flos Carthami, Caulis Spatholobi, Herba Dianthi, Caulis Akebiae, Radix Angelicae Sinensis, Radix Codonopsis, Radix Glycyrrhizae, Semen Persicae, Ligusticum chuanxiong Hort are cleaned, dry, weighed, pulverizing medicinal materials becomes coarse powder;
(2) medicinal material coarse powder is added 1-5 water doubly, be heated to boiling, make it the 1-4h that seethes with excitement, each extraction 1-4 time, be back to extractum, vacuum drying powdered obtains extract;
(3) Halloysitum Rubrum, calcium lactate are mixed with above extract with proper proportion, stir 10-20min.
6. a kind of pharmaceutical composition preventing and treating milch cow placenta retention according to claim 5 is characterized in that adding adjuvant.
7. a kind of pharmaceutical composition preventing and treating milch cow placenta retention according to claim 6 is characterized in that its adjuvant adds wherein one or more such as silicon dioxide, dextrin, sucrose.
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| CN201510350213.1A CN104873593B (en) | 2015-06-24 | 2015-06-24 | A kind of pharmaceutical composition and preparation method thereof of prevention milk cow retention of afterbirth |
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| CN201510350213.1A CN104873593B (en) | 2015-06-24 | 2015-06-24 | A kind of pharmaceutical composition and preparation method thereof of prevention milk cow retention of afterbirth |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106389977A (en) * | 2016-11-17 | 2017-02-15 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese composite preparation for treating retained fetal membranes of dairy cow and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972331A (en) * | 2010-10-20 | 2011-02-16 | 罗志诣 | Chinese medicinal composition for treating cow afterbirth retention |
| CN104173660A (en) * | 2014-09-04 | 2014-12-03 | 青岛农业大学 | Composition for treating retained placenta in cattle and preparation method of composition |
-
2015
- 2015-06-24 CN CN201510350213.1A patent/CN104873593B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972331A (en) * | 2010-10-20 | 2011-02-16 | 罗志诣 | Chinese medicinal composition for treating cow afterbirth retention |
| CN104173660A (en) * | 2014-09-04 | 2014-12-03 | 青岛农业大学 | Composition for treating retained placenta in cattle and preparation method of composition |
Non-Patent Citations (1)
| Title |
|---|
| 刘志英等: "浅谈奶牛胎衣不下的中西医防治", 《北方牧业》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106389977A (en) * | 2016-11-17 | 2017-02-15 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese composite preparation for treating retained fetal membranes of dairy cow and preparation method thereof |
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