CN103735692A - Traditional Chinese medicinal composition for treating pig dysentery - Google Patents
Traditional Chinese medicinal composition for treating pig dysentery Download PDFInfo
- Publication number
- CN103735692A CN103735692A CN201410033472.7A CN201410033472A CN103735692A CN 103735692 A CN103735692 A CN 103735692A CN 201410033472 A CN201410033472 A CN 201410033472A CN 103735692 A CN103735692 A CN 103735692A
- Authority
- CN
- China
- Prior art keywords
- parts
- weight portion
- traditional chinese
- chinese medicinal
- medicinal composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicinal composition for treating pig dysentery. The traditional Chinese medicinal composition comprises the following raw materials in parts by weight: 130-170 parts of saruma henryi, 110-130 parts of wild hemp grass, 90-110 parts of euphorbia humifusa, 20-40 parts of rhizoma atractylodis, 20-40 parts of coptidis rhizome, 10-30 parts of mangnolia officinalis, 10-20 parts of poria cocos, 8-12 parts of pericarpium citri reticulatae, 8-12 parts of myristica fragrans and 10-20 parts of hawthorns. The traditional Chinese medicinal composition disclosed by the invention has an outstanding treating effect on the pig dysentery, in particular on the rotavirus dysentery; the curing rate is over 89 percent, the effectiveness is over 4 percent, and the total effectiveness is over 93 percent; furthermore, the composite is safe and does not have toxic or side effects; the phenomenon of the use of antibiotic of the conventional treatment is avoided.
Description
Technical field
The invention belongs to field of veterinary, be specifically related to a kind of Chinese prescription for the treatment of diarrhea of pigs disease.
Background technology
Viral diarrhea disease is one of important diseases of harm pig industry, once morbidity causes piglet death, becomes pig to lose flesh, and price of deed rate reduces, and increases and adds feeding cost etc.It is reported, it is 80% that U.S. ablactational baby pig infects positive rate, and case fatality rate is 15%, and when having mixed infection, case fatality rate is higher; China Lee state equality has been carried out the investigation of piglet RV infection conditions with RV antigen enzyme labeled diagnosis reagent box to Foochow, Fujian Province, selected swine farms coequally of south, 10 ages in days to the positive rate of ablactational baby pig up to 82.3%～91.7%; 2100 piglets that Cheng Jian equals in October, 2,002 90 families, small towns, 7 of Zhuanglang County, Gansu Province to be raised have frequently carried out preliminary survey, 1460 of morbidity piglets, and sickness rate reaches 69.5%; The nineteen nineties such as Wang Yuchun amount to 121 pig farms to domestic 19 provinces and do serosurvey, do not find negative swinery.Its frequency of disease development and be distributed with obvious difference under different regions, different time and different external condition.Piglet rotavirus diarrhea disease in the sky and water, Gansu Province, Pingliang, Lanzhou mostly is inapparent infection, and 10 ages in days mostly are profiling infection when weaning, and diarrhoea, the symptom of becoming thin are obvious, not remarkable by effect after antibiotics treatment.Because these areas disperse to raise on a small scale, poor infrastructure, improved variety degree is low, and breeding technology is backward etc., causes the rate of positive infection of the piglet rotavirus of raising scattered to reach as high as 32.61%, and most area the rate of positive infection is on average all more than 25%.
Rotavirus is discharged to external environment with feces, pollutes feedstuff, drinking-water, apparatus, soil etc., through digestive tract infection.The piglet of each age in days and the antenatal 5 days equal susceptibles of sow to 2 weeks puerperal.Though non-evident sympton when sow infects, infects piglet through excrement, a mouthful approach transmitted virus, causes piglet diarrhea.Piglet morbidity starts to occur anorexia, uneasy, there is once in a while vomiting, after 1～4 hour, there is watery diarrhea in severe patient, feces is yellow suffers from diarrhoea sustainable 3～5 days to white, containing floccule, in diarrhoea, after 2～5 days, may have death, along with the increase mortality rate at age reduces, piglets more than 14 ages in days is seldom dead.If mix and infect aggravation with transmissible gastroenteritis and escherichia coli, mortality rate is higher.Once if the morbidity of scale, Intensive Farm of Pig Raising will cause serious economic loss.
At present, there is no the medicine of effective treatment pig virus diarrhoea disease.Preventing these sick effective ways is to strengthen feeding and management and effective vaccine inoculation.Grasp the development that the dynamic change of diarrhoeal diseases and influence factor can be its diagnosis and vaccine, veterinary drug scientific basis is provided, need further to explore new control medicine, solution is to antibiotic drug resistance and residue problem, and the new veterinary drug of developing new type of safe, high-efficiency environment friendly has become the task of top priority.
Summary of the invention
The object of this invention is to provide a kind of Chinese prescription for the treatment of diarrhea of pigs disease.
It is as follows that the present invention realizes the technical scheme that above-mentioned purpose adopts:
A kind of Chinese prescription for the treatment of diarrhea of pigs disease, its feature is, described Chinese prescription comprises: Herba Asari 130-170 weight portion, wild flax grass 110-130 weight portion, Herba Euphorbiae Humifusae 90-110 weight portion, Rhizoma Atractylodis 20-40 weight portion, Rhizoma Coptidis 20-40 weight portion, Cortex Magnoliae Officinalis 10-30 weight portion, Poria 10-20 weight portion, Pericarpium Citri Reticulatae 8-12 weight portion, Semen Myristicae 8-12 weight portion, Fructus Crataegi 10-20 weight portion.
The using method of the Chinese prescription of above-mentioned treatment diarrhea of pigs disease, described Chinese prescription decocts with water to obtain medicinal liquid, by crude drug amount 9-20mg/ time, ill pig is gavaged to medicinal liquid.
Herba Asari in side, wild flax grass, Herba Euphorbiae Humifusae, Rhizoma Coptidis heat-clearing and toxic substances removing, drying damp and strengthening spleen be principal agent; Pericarpium Citri Reticulatae, Rhizoma Atractylodis relieving distension by promoting circulation of QI, regulating qi-flowing for strengthening spleen are accessory drugs; Cortex Magnoliae Officinalis, Poria, Semen Myristicae dampness diuretic, warming spleen and stopping diarrha be adjuvant drug; Fructus Crataegi relieving diarrhea with astringents is for making medicine.All medicines share above, play altogether the effect of heat-clearing and toxic substances removing, warming middle-JIAO and strengthening the spleen, dampness removing and diarrhea-relieving.
Chinese prescription of the present invention to diarrhea of pigs disease particularly rotaviral enteritis there is significant therapeutic effect, cure rate is more than 89%, and effective percentage is more than 4%, and total effective rate is more than 93%, and this prescription safe without toxic side effect, is used antibiotic problem while having avoided existing treatment.
The specific embodiment
Below in conjunction with embodiment, the present invention is described in further details.
Embodiment 1
Herba Asari 130g, wild flax grass 110g, Herba Euphorbiae Humifusae 90g, Rhizoma Atractylodis 20g, Rhizoma Coptidis 20g, Cortex Magnoliae Officinalis 10g, Poria 10g, Pericarpium Citri Reticulatae 8g, Semen Myristicae 8g, Fructus Crataegi 10g.
Using method: accurately take above-mentioned medical material, add the water of 10 times of weight, decoct each 1.5 hours 3 times, collecting decoction, it is 1.13(60 ℃ that decocting liquid is concentrated into relative density), then to add water move to medicinal liquid crude drug content be 1.3mg/mL, gavages, each 7-15ml, 2 days is 1 course for the treatment of at every day 2-3 time.
Embodiment 2
Herba Asari 150g, wild flax grass 120g, Herba Euphorbiae Humifusae 100g, Rhizoma Atractylodis 30g, Rhizoma Coptidis 30g, Cortex Magnoliae Officinalis 20g, Poria 15g, Pericarpium Citri Reticulatae 10g, Semen Myristicae 10g, Fructus Crataegi 15g.
Using method: accurately take above-mentioned medical material, add the water of 10 times of weight, decoct each 1.5 hours 3 times, collecting decoction, it is 1.13(60 ℃ that decocting liquid is concentrated into relative density), then to add water move to medicinal liquid crude drug content be 1.3mg/mL, gavages, each 7-15ml, 2 days is 1 course for the treatment of at every day 2-3 time.
Embodiment 3
Herba Asari 170g, wild flax grass 130g, Herba Euphorbiae Humifusae 110g, Rhizoma Atractylodis 40g, Rhizoma Coptidis 40g, Cortex Magnoliae Officinalis 30g, Poria 20g, Pericarpium Citri Reticulatae 12g, Semen Myristicae 12g, Fructus Crataegi 20g.
Using method: accurately take above-mentioned medical material, add the water of 10 times of weight, decoct each 1.5 hours 3 times, collecting decoction, it is 1.13(60 ℃ that decocting liquid is concentrated into relative density), then to add water move to medicinal liquid crude drug content be 1.3mg/mL, gavages, each 7-15ml, 2 days is 1 course for the treatment of at every day 2-3 time.
clinical trial
The piglet of diarrhoeal diseases is suffered from treatment, and first scraping anus fresh excreta (dead pig is cutd open and searches intestinal mucosa and feces) is put the 2-6 ℃ of case that keeps sample and preserved censorship.Then gavage the medicinal liquid of embodiment 2: 1-3 age in days piglet gavages 7-10ml, every day 2-3 time at every turn; 4-10 age in days piglet gavages 10-12ml, every day 2-3 time at every turn; The above piglet of 10 age in days gavages 15ml, every day 2-3 time at every turn.2 days was 1 course for the treatment of, did not all use any medicine before treatment.
On Tian Peng pig farm, Maiji District, Tianshui of Gansu Province, treat altogether 111 of piglets, cure altogether 92, cure rate 82.9%, effective 2, effective percentage 1.8%, invalid 17, total effective rate 84.7%.
On Wei Ya pig farm, Maiji District, Tianshui of Gansu Province, treat altogether 30 of piglets, cure altogether 27, effective 1, invalid 2; Cure rate 90%, total effective rate 93.3%.
On pig farm, Wanrong, Yongdeng County, Lanzhou City, Gansu Province, treat altogether 105 of piglets, cure altogether 101, cure rate 96.2%; Effective 4, effective percentage 3.8%, total effective rate 100%.
Luo Men town, Wushan County, Gansu Province animal and veterinary work station, with 58 of this decoction for the treatment pig farmer piglets, is cured 53, cure rate 91.37% altogether; Effective 3, effective percentage 5.17%, invalid 2; Total effective rate 96.54%.
Gansu Province autonomous county of Zhang Chuan Hui ethnic group animal and veterinary work station, with 109 of this decoction for the treatment piglets, is cured 95, cure rate 88.07% altogether; Effective 6, effective percentage 5.5%, invalid 8; Total effective rate 93.57%.
Below treat altogether 413, cure 368, cure rate 89.35%, effective 16, effective percentage 4.12%; Invalid 29, total significant figure is 384, and total effective rate is 93.46%.
1, the detection of virus: rotavirus test kit detection method
(1) detection kit.The prosperous triple real-time fluorescent RT-PCR detection reagent boxes of century unit, Anheal Laboratories Co., Ltd produces, lot number: TGEV PEDV PRV-20130311P, TGEV PEDV PRV-20130819P.
(2) processing of sample.Dead piglet cuts open inspection scraping intestinal mucosa and feces, live hog to be checked are got anus fresh excreta.Get and detect sample in 1.5ml sterilizing centrifuge tube, add the vibration of 1ml normal saline vortex, the centrifugal 2min of 8000rpm, gets supernatant 100 μ l in 1.5ml sterilizing centrifuge tube.Get processed sample, negative control, add respectively lysate 600 μ l, fully put upside down and mix, the standing 5min of room temperature.Liquid is sucked in adsorption column to the centrifugal 30s of 13000rpm.Discard the liquid in collecting pipe, add 600 μ l washing liquids, the centrifugal 30s of 13000rpm.Discard liquid in collecting pipe, add 600 μ l washing liquids, the centrifugal 2min of 13000rpm void column, removes residual cleaning mixture.Adsorption column is moved in new 1.5ml centrifuge tube, to post central authorities, add eluent 40 μ l, the standing 1min of room temperature, the centrifugal 30s of 13000rpm, in centrifuge tube, liquid is template ribonucleic acid.
(3) configuration of reaction system.
If test sample, negative control and positive control summation are N, reaction system configuration is as follows:
After the reaction system of configuration above is fully mixed, each 17 μ l in the each reaction tube of subpackage.Get respectively 8 μ l template ribonucleic acids, add in corresponding reaction tube, in positive control pipe, add 8 μ l positive control RNA, mix and carry out labelling, probe to be checked is set, and wherein TGEV fluorescence report group is FAM, and PEDV fluorescence report group is VIC or HEX, PRV-A fluorescence report group is LIZ or Cy5, and quenching group is None.On fluorescent PCR instrument, carry out following reaction: 48 ℃ of 10min, 95 ℃ of 10min; The 95 ℃ of 15s that circulate, 60 ℃ of 45s, totally 40 times, the second step (60 ℃ of 45s) of each circulation is collected fluorescence signal.
(4) result is judged.If test sample LIZ fluorescence signal Ct value≤35 also occur that specific amplification curve is the PRV-A positive; Also there is specific amplification curve in test sample 36 < Ct≤38, after need again trying again, carries out result judgement, as identical in two times result, is judged to be the positive; During test sample Ct value > 38, exceed this method detection sensitivity scope, be judged to be feminine gender.
2, sample detection result
Small Intestine of Piglets content to 4 plants such as pig farms, Wanrong, Yongdeng County of Lanzhou or feces totally 31 pathological material of diseases carry out rotavirus detection with rotavirus test kit, also there is 24 of the pathological material of diseases of specific amplification curve in Ct value≤35, positive rate is 77.42%, and really disease is rotaviral enteritis.The results are shown in following table:
safety evaluatio
For the toxic and side effects of clear and definite this preparation, and to its safety make accurately, objective appraisal, for clinical application provides scientific basis, guarantee drug safety, carried out the toxicity test of this preparation.
By to mouse gavaging preparation LD50, test shows,, with the maximum administration volume administration of drug level 1g/mL and tolerance, there is no dead mouse, the LD50 of gastric infusion mode cannot be measured, the LD50>40000mg/kg body weight of said preparation oral administration gavage can only be shown.By intraperitoneal injection, under drug level 1g/mL and maximum administration volume, also without dead mouse, cannot measure the LD50 of intraperitoneal injection mode, therefore think the LD50>10000mg/kg body weight of lumbar injection.According to result evaluation standard and the toxicological evaluation standard of < < veterinary drug test requirement specification compilation > >, judge that this preparation reality is nontoxic.In maximum dosage-feeding test, 4 gastric infusions in 16h, each maximum administration volume administration with mouse stomach administration, after administration, occur slightly uncomfortable, do not like under activity, feed intake degradation symptom, in the 10d of normal observation, white mice in order, do not occur abnormal phenomena, and none is only dead.
In order to grasp because using continuously the development and the recovery situation that produce after toxicity and the order of severity and drug withdrawal, for drafting data for clinical drug use dosage, provide reference.Press 40000mg/kg group, 20000mg/kg group, 10000mg/kg group and 0 dosage group oral administration gavage administration, 28d has carried out subacute toxicity test continuously.Within experimental period, outside high dose loses weight obviously, the diet of all the other each test group mices, behavior, feces are all normal, physically well develop, without CREA, ALT in any poisoning symptom and hemogram and serum, ALP, AST, TP, ALB all in normal range, illustrate that this preparation is safe.
Claims (2)
1. treat the Chinese prescription of diarrhea of pigs disease for one kind, it is characterized in that, described Chinese prescription comprises: Herba Asari 130-170 weight portion, wild flax grass 110-130 weight portion, Herba Euphorbiae Humifusae 90-110 weight portion, Rhizoma Atractylodis 20-40 weight portion, Rhizoma Coptidis 20-40 weight portion, Cortex Magnoliae Officinalis 10-30 weight portion, Poria 10-20 weight portion, Pericarpium Citri Reticulatae 8-12 weight portion, Semen Myristicae 8-12 weight portion, Fructus Crataegi 10-20 weight portion.
2. power requires to treat described in 1 the using method of the Chinese prescription of diarrhea of pigs disease, and described Chinese prescription decocts with water to obtain medicinal liquid, by crude drug amount 9-20mg/ time, ill pig is gavaged to medicinal liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410033472.7A CN103735692B (en) | 2014-01-24 | 2014-01-24 | A kind of Chinese prescription for the treatment of diarrhea of pigs disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410033472.7A CN103735692B (en) | 2014-01-24 | 2014-01-24 | A kind of Chinese prescription for the treatment of diarrhea of pigs disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103735692A true CN103735692A (en) | 2014-04-23 |
| CN103735692B CN103735692B (en) | 2016-01-20 |
Family
ID=50492807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410033472.7A Expired - Fee Related CN103735692B (en) | 2014-01-24 | 2014-01-24 | A kind of Chinese prescription for the treatment of diarrhea of pigs disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103735692B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435327A (en) * | 2014-11-11 | 2015-03-25 | 成都果睿医药科技有限公司 | Coptis-chinensis-containing pharmaceutical composition for treating diarrhea |
| CN106822890A (en) * | 2017-01-19 | 2017-06-13 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of pharmaceutical composition for preventing and treating diarrhea of weaned piglets and its preparation method and application |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813971A (en) * | 2005-11-23 | 2006-08-09 | 贵州宏奇药业有限公司 | Effervescent tablet for treating infant diarrhea |
| JP2006333842A (en) * | 2005-06-06 | 2006-12-14 | Unitika Ltd | Compounding agent for fodder |
| CN101708327A (en) * | 2009-10-27 | 2010-05-19 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating diseases of weakness of spleen and stomach and indigestion and preparation method thereof |
| CN101961473A (en) * | 2010-04-27 | 2011-02-02 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating diarrhea and preparation method thereof |
| CN102727809A (en) * | 2012-07-04 | 2012-10-17 | 许瑞琴 | Traditional Chinese medicine for treating infantile diarrhea |
| CN102764390A (en) * | 2012-06-28 | 2012-11-07 | 张延娟 | Traditional Chinese medicine for treating diarrhea |
-
2014
- 2014-01-24 CN CN201410033472.7A patent/CN103735692B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006333842A (en) * | 2005-06-06 | 2006-12-14 | Unitika Ltd | Compounding agent for fodder |
| CN1813971A (en) * | 2005-11-23 | 2006-08-09 | 贵州宏奇药业有限公司 | Effervescent tablet for treating infant diarrhea |
| CN101708327A (en) * | 2009-10-27 | 2010-05-19 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating diseases of weakness of spleen and stomach and indigestion and preparation method thereof |
| CN101961473A (en) * | 2010-04-27 | 2011-02-02 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating diarrhea and preparation method thereof |
| CN102764390A (en) * | 2012-06-28 | 2012-11-07 | 张延娟 | Traditional Chinese medicine for treating diarrhea |
| CN102727809A (en) * | 2012-07-04 | 2012-10-17 | 许瑞琴 | Traditional Chinese medicine for treating infantile diarrhea |
Non-Patent Citations (3)
| Title |
|---|
| 张倩菲: "小儿腹泻的常见原因分析及护理措施", 《科技资讯》 * |
| 荆所义等: "《新编猪病防治技术手册》", 29 February 2004, 中原农民出版社 * |
| 陈德润: "浅论泄泻", 《南京中医学院学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435327A (en) * | 2014-11-11 | 2015-03-25 | 成都果睿医药科技有限公司 | Coptis-chinensis-containing pharmaceutical composition for treating diarrhea |
| CN106822890A (en) * | 2017-01-19 | 2017-06-13 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of pharmaceutical composition for preventing and treating diarrhea of weaned piglets and its preparation method and application |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103735692B (en) | 2016-01-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101773594B (en) | Composition for treating sheep diarrhea and preparation method thereof | |
| CN103893272B (en) | A kind of pharmaceutical composition and preparation method for the treatment of livestock dysentery | |
| CN103006792A (en) | Veterinary drug for preventing livestock bowel diseases, preparation method of drug, and feed | |
| CN102283931A (en) | Traditional Chinese medicine composition for preventing and curing diarrhea of suckling pigs | |
| CN102302778A (en) | Preparation method and application of traditional Chinese medicinal immunoglobulin compound preparation | |
| CN103006916A (en) | Pure traditional Chinese medicine recipe for curing various animal diarrhoeal diseases and preparation method of pure traditional Chinese medicine recipe | |
| CN103202899B (en) | Traditional Chinese medicine feed additive for preventing and curing livestock and poultry diarrhea | |
| CN102579597B (en) | Chinese herbal compound prescription for preventing and curing mammitis of mammalian livestock and method for preparing same | |
| CN103735692B (en) | A kind of Chinese prescription for the treatment of diarrhea of pigs disease | |
| CN103655967A (en) | Traditional Chinese medicinal composition for treating piglet diarrhea and preparation method thereof | |
| CN104147327A (en) | Pharmaceutical preparation for bacillary dysentery of piglets | |
| CN104147190B (en) | A kind of Chinese medicine composition and its preparation method treating lamb dysentery | |
| CN102973702A (en) | Piglet yellow and white scour treatment compound traditional Chinese medicine composition and preparation method thereof | |
| CN112675234A (en) | Preparation for treating animal damp-heat diarrhea and dysentery, preparation method and quality detection method | |
| CN105497367A (en) | Composition for treating transmissible gastroenteritis of swine and preparation method of composition | |
| CN104666548A (en) | Traditional Chinese medicine composition for treating intestinal diseases in livestock and poultry and preparation method of traditional Chinese medicine composition | |
| CN103202908A (en) | Chinese herbal medicine feed additive for preventing and curing colibacillosis | |
| CN101209304A (en) | Chinese medicinal granule with clearing heat and detoxication, blood-nourishing and dysentery-stopping efficacy | |
| CN104189167B (en) | A kind of treat cataplasma of piglet diarrhea and preparation method thereof | |
| CN113350429A (en) | Traditional Chinese medicine composition for preventing and treating African swine fever disease and preparation method and application thereof | |
| CN102961563B (en) | Pharmaceutical composition for treating livestock and poultry dysentery and preparation method thereof | |
| CN103203004B (en) | Medicinal composition with dysentery stopping effect and preparation method thereof | |
| CN104825753A (en) | Traditional Chinese medicine composition for control of newborn piglet diarrhea by applying composition to sow | |
| CN101396427A (en) | Traditional Chinese medicine oral liquid for treating poultry virus hepatitis and hepatic injury | |
| CN101209315A (en) | Chinese medicinal injection with antimicrobial and anti-inflammation, milk-smoothing and mass-dissipating efficacy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160120 Termination date: 20210124 |