CN103202908A - Chinese herbal medicine feed additive for preventing and curing colibacillosis - Google Patents
Chinese herbal medicine feed additive for preventing and curing colibacillosis Download PDFInfo
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Abstract
The invention belongs to the technical field of veterinary medicines, and in particular relates to a Chinese herbal medicine feed additive for preventing and curing colibacillosis. The feed additive mainly comprises the following components in parts by weight: 10-20 parts of coptis, 10-20 parts of phellodendron bark, 15-20 parts of wild chrysanthemum flower and 15-20 parts of cortex moutan radicis. The Chinese herbal medicine feed additive for preventing and curing colibacillosis disclosed by the invention has a prominent effect on preventing and curing colibacillosis, and is also effective to infection caused by gramnegativebacteria and diarrhoea caused by multiple reasons, and furthermore, the Chinese herbal medicine feed additive has antiviral efficacy, and can effectively avoid the problems of milk resistance and medicine residue and foodstuff safety.
Description
Technical field
The invention belongs to the veterinary drug technical field, particularly the Chinese herbal feed additive of a kind of prevention and treatment colibacillosis.
Background technology
Along with the fast development of Chinese national economy and the raising day by day of living standards of the people, urban and rural residents not only obviously rise to animal products such as meat, egg, milk and livestock and poultry product demands such as (as smoked intestinal class, smoked Petaso, beans spiced and stewed food, pickled and cured meat, the milk powder of boiling of boiling), and the prescription of animal products improved constantly, as require product safety, green, drug residue free, nuisanceless etc.For satisfying the vigorous market demand; the livestock and poultry breeding industry of China is constantly developed; simultaneously along with breeding environment constantly worsens; disease incident is more and more higher; a large amount of medicines adds causes the animal products quality security problem to become increasingly conspicuous; especially CCTV1 in 2012; events such as numerous medium unit exposure speed live chickens such as CCTV13 and Focus and false veterinary drug cause great disturbance in the industry; the public who brings thus is to the trust crisis of animal products quality safety; simultaneously a large amount of abuses of antibiotics cause medicine easily residual; medicine is easily residual to be to influence meat; egg; milk waits the key factor of animal products safety; human body is often taken in the left drugs such as antibiotic of low dosage; can accumulate in vivo gradually and cause various organ generation pathological changes; produce allergy; anaphylaxis; immunosuppressant etc.; final harm humans health, the development that will continue for China's animal husbandry science causes and has a strong impact on.
The poultry colibacillosis has become one of important diseases of restriction China aquaculture development at present, has brought bigger economic loss for China's aquaculture.Escherichia coli cause of disease serotype is more, the poultry disease can be different in clinical, the state of an illness is outbreak repeatedly easily, there is bigger difficulty when therefore treating, adds a large amount of abuse of antibiotics preventions of plant and treatment, cause the appearance of endurance strain, extremely difficult during treatment, more worrying is much to prevent the medicine of colibacillosis easily residual, and therefore harm humans health cause the prevention of poultry colibacillosis and curative drug blank to occur.Colibacillosis still lacks at present clinically prevents and treats Chinese medicine feed additive preferably, therefore demands developing a kind of safe and reliable prevention and treatment colibacillosis Chinese herbal feed additive urgently to satisfy the demand of actual production.
Summary of the invention
The object of the present invention is to provide the Chinese herbal feed additive of a kind of prevention and treatment colibacillosis.
The technical solution used in the present invention is as follows:
The Chinese herbal feed additive of prevention and treatment colibacillosis, described feed additive mainly is made up of the following weight parts component: Rhizoma Coptidis 10-20 part, Cortex Phellodendri 10-20 part, Flos Chrysanthemi Indici 15-20 part, Cortex Moutan 15-20 part.
Further, in weight portion, described feed additive also comprises: Herba Lophatheri 10-15 part, Radix Paeoniae Rubra 10-15 part, Radix Scutellariae 10-15 part, Herba Houttuyniae 10-15 part, Spica Prunellae 15-20 part and Rhizoma Dryopteris Crassirhizomatis 10-15 part.
Colibacter gram negative bacteria, this bacterium have become one of important pathogen in the harm aquaculture.The animal large intestine bacillosis is because of the animal species difference in actual clinical, and disease can be different.Ophthalmia, airsacculitis, pericarditis, perihepatitis, enteritis, oophoritis, salpingitis, yolk peritonitis, arthritis etc. can appear as poultry; Pig diarrhoea occurs as draws HUANGBAI(sic) smell as of rotten fish feces, symptom such as become thin.The symptom that colibacillosis and gram positive bacterial infection cause is full of three warmers, internal organs excess-heat or damp and hot disease from the dialectical genus pathogenic heat of Chinese veterinarian's angle.So with the clear eliminating heart-fire of Rhizoma Coptidis, clear middle Jiao's that holds concurrently fire is principal agent in the side; The clear part of the body cavity above the diaphragm housing the heart and lungs lung-fire of Radix Scutellariae, Cortex Phellodendri is rushed down the fire of part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels Liver and kidney, and Folium Bambusae rushes down the fire of three warmers clearly, diuresis, heat conduction is descending, and Rhizoma Osmundae, Spica Prunellae, Flos Chrysanthemi Indici, Radix Paeoniae Rubra, Herba Houttuyniae heat-clearing and toxic substances removing etc. are accessory drugs; Cortex Moutan clearing away heat and cooling blood, promoting blood circulation to remove blood stasis are adjuvant drug.All medicines share, and play the effect of clearing away heat-fire, detoxifcation, antibiotic, antiinflammatory altogether.
According to the dialectical theory of Chinese veterinarian, this Chinese herbal medicine additive not only prevents and to treat poultry colibacillosis effect remarkable, and the diarrhoea that the infection that gram negative bacteria is caused and a variety of causes cause is effective equally, in addition also has the effect of antiviral.The prevention total effective rate is more than 96%.When being used for the treatment of, total effective rate is more than 97%.
Feed additive of the present invention is regulated using dosage can prevent or treat colibacillosis significantly, and during as prevention, general addition is 0.4-0.6%; During treatment, using dosage is 0.5%-1.5%.During use, after the said medicine pulverizing, cross 300 mesh sieves, obtain powder.Spice mixed feeding method can be adopted in the large-scale cultivation field, and raising the family scattered both can the spice mixed feeding, also can be with powder decocting extracting juice drinking-water, and big domestic animal also can be adopted and be gavaged.Chinese herbal medicine additive of the present invention is pure tcm product, can make various dosage forms such as powder, oral liquid, granule, tablet, pill, unguentum etc., can avoid anti-milk, drug residue and food-safety problem effectively, suit in herding is produced, to promote.
The specific embodiment
Below with specific embodiment technical scheme of the present invention is described, but protection scope of the present invention is not limited thereto:
Embodiment 1
The Chinese herbal feed additive of prevention and treatment colibacillosis, it is composed as follows:
Rhizoma Coptidis 15g, Cortex Phellodendri 15g, Flos Chrysanthemi Indici 17.5g, Cortex Moutan 17.5g.
All medicine pulverizations are crossed 300 mesh sieves, are powder.
Embodiment 2
The Chinese herbal feed additive of prevention and treatment colibacillosis, it is composed as follows:
Rhizoma Coptidis 10g, Cortex Phellodendri 10g, Flos Chrysanthemi Indici 15g, Cortex Moutan 15g.
All medicine pulverizations are crossed 300 mesh sieves, are powder.
Embodiment 3
The Chinese herbal feed additive of prevention and treatment colibacillosis, it is composed as follows:
Rhizoma Coptidis 20g, Cortex Phellodendri 20g, Flos Chrysanthemi Indici 20g, Cortex Moutan 20g.
All medicine pulverizations are crossed 300 mesh sieves, are powder.
Embodiment 4
The Chinese herbal feed additive of prevention and treatment colibacillosis, it is composed as follows:
Rhizoma Coptidis 15g, Cortex Phellodendri 15g, Flos Chrysanthemi Indici 17.5g, Cortex Moutan 17.5g, Herba Lophatheri 12.5g, Radix Paeoniae Rubra 12.5g, Radix Scutellariae 12.5g, Herba Houttuyniae 12.5g, Spica Prunellae 17.5g and Rhizoma Dryopteris Crassirhizomatis 12.5g.
All medicine pulverizations are crossed 300 mesh sieves, are powder.
Embodiment 5
The Chinese herbal feed additive of prevention and treatment colibacillosis, it is composed as follows:
Rhizoma Coptidis 10g, Cortex Phellodendri 10g, Flos Chrysanthemi Indici 15g, Cortex Moutan 15g, Herba Lophatheri 10g, Radix Paeoniae Rubra 10g, Radix Scutellariae 10g, Herba Houttuyniae 10g, Spica Prunellae 15g and Rhizoma Dryopteris Crassirhizomatis 10g.
All medicine pulverizations are crossed 300 mesh sieves, are powder.
Embodiment 6
The Chinese herbal feed additive of prevention and treatment colibacillosis, it is composed as follows:
Rhizoma Coptidis 20g, Cortex Phellodendri 20g, Flos Chrysanthemi Indici 20g, Cortex Moutan 20g, Herba Lophatheri 15g, Radix Paeoniae Rubra 15g, Radix Scutellariae 15g, Herba Houttuyniae 15g, Spica Prunellae 20g and Rhizoma Dryopteris Crassirhizomatis 15g.
All medicine pulverizations are crossed 300 mesh sieves, are powder.
Effect:
Embodiment 1 additive spice is for oral administration: during treatment, big domestic animal such as cattle, horse and camel: 150-300g/ head; Pig, sheep: 50-100g/ head, fox, Nyctereutes procyonoides, ermine: 15-30g/ only, rabbit: 6-12g/ only, birds: 1-3g/ only adds up curative effect after being used in conjunction 5 days.Preventive dose reduces by half.
Efficacy determination: protective rate is being considered as more than 96% effectively during prevention.During treatment, took medicine 5, symptom of diarrhea is eliminated, and not repeatedly, is considered as curing in 7 days; In 10 days, no symptom of diarrhea is considered as effectively, otherwise be considered as invalid.
Effect sees table 1(prevention for details) and table 2(treatment).
Table 1
Table 2
Embodiment 4 additive spices are for oral administration: during treatment, spice takes big domestic animal such as cattle, horse and camel orally: the 150-300g/ head; Pig, sheep: 50-100g/ head, fox, Nyctereutes procyonoides, ermine: 15-30g/ only, rabbit: 6-12g/ only, birds: 1-3g/ only or according to 0.5%-1.5% spice mixed feeding, adds up curative effect after being used in conjunction 5 days.Preventive dose reduces by half.
Efficacy determination is with embodiment 1 additive.
Effect sees table 3(prevention for details) and table 4(treatment).
Table 3
Table 4
Concrete case 1
In July, 2010,18000 Ai Wei mattresses of the Wang of Xinzheng City raising, randomly draw 500 and be divided into test group and matched group, except according to routine raising, immunity inoculation, the sterilization etc., get the Chinese medicine composition of embodiment 1 and pulverize, cross 300 mesh sieves, test group is made granule after adding feedstuff and mix homogeneously according to 0.4% ratio, add since 9 ages in days, until delivering for sale.Except natural death, matched group amounts to 27, mortality rate 10.8% because colibacillosis causes dead chicken during this time; Test group causes 8 of dead chickens, mortality rate 3.2% because of colibacillosis.As seen, additive prevention colibacillosis effect of the present invention is remarkable.
Concrete case 2
In JIUYUE, 2010, Huixian, Xinxiang Zhao's pig farm extract out at random with approach in pig house term 24 of sows, 12 of test group, 12 of matched groups, test natural law 10 days, test group and matched group adopt additive of the present invention to be used for the prevention yellow scour of piglet except according to the raising of routine raising pattern, immunity inoculation, the sterilization etc. during this time.Get the Chinese medicine composition of embodiment 2 and pulverize, cross 300 mesh sieves, test group makes an addition to feedstuff and concentrates once use according to the 75g/ head, brings into use, and is used in conjunction 10 days in antenatal 3 days.Diarrhoea, effective percentage 100% do not appear in the piglet of 12 sows products of test group during this time; There are 12 diarrhoea to occur in 133 piglets that 12 sows of matched group produce, sickness rate 9.02%, the morbidity back is according to the 50g/ head, and the decocting extracting juice gavages, and once a day, is used in conjunction 5, and recovery from illness after 5 days did not occur repeatedly in 7 days.As seen, additive prevention of the present invention and treatment yellow scour of piglet effect are remarkable.
Concrete case 3
In June, 2010,25000 Carnis Coturnicis japonicaes of suburb, Zhengzhou Korea Spro's raising are randomly drawed 600, are divided into test group and matched group, each 300, two groups in unified house according to routine raising, immunity inoculation, sterilization etc.Adopt additive of the present invention to be used for the prevention colibacillosis.Get the Chinese medicine composition of embodiment 3 and pulverize, cross 300 mesh sieves, after test group is added into feedstuff and mix homogeneously according to 0.4% ratio, free choice feeding, since 12 ages in days until delivering for sale.Except natural death, matched group amounts to 31, mortality rate 10.3% because of the Carnis Coturnicis japonicae of colibacillosis death during this time; Test group is because of 7 of the Carnis Coturnicis japonicaes of colibacillosis death, mortality rate 2.00%.As seen, additive prevention colibacillosis effect of the present invention is remarkable.
Concrete case 4
In March, 2010,78 piglets raising in Tanghe County, Nanyang Pan's the pig house are suffered from diarrhoea suddenly, discharge milky or linen pulpous state, pasty state stickiness feces, stench, have bubble or the blood streak sometimes, it is tired to follow disease pig appearance spirit, and thick random by hair, body surface is unglazed, loss of appetite, myasthenia of limbs, walking is unstable or the ground that crouches is difficult rises, feces is the canescence stench, slack anus, feces incontinence, become thin, dewater, indivedual pig extremely feebles and dead, case fatality rate 7.69%.Pathological change is become thin for the pig corpse of dying of illness, and mucosa is pale, and by fecal pollution, intestinal mucosa was catarrhal inflammation around anus reached, the intestinal wall attenuation, and colonic has milky or canescence pasty state or ointment shape content, mesenteric lymph node mild swelling etc.Through clinical symptoms, pathological change and laboratory diagnosis, be diagnosed as piglet pujos blancos.Get the Chinese medicine composition of embodiment 4 and pulverize, cross 300 mesh sieves, test group is according to the 50g/ head, and the decocting extracting juice gavages, once a day, serve on 5, the salt of fluid infusion simultaneously drinking-water is used in conjunction 3 days, and symptom disappears substantially after 5 days, the state of an illness did not appear repeatedly in 7 days, recovery from illness, none piglet death during 10 days innerlich anwendens.
Concrete case 5
In June, 2011,3000 meat-type duck of Weizhi County grandson's raising, it is tired spirit to occur 18 age in days ducks, lack and eat or do not eat, happiness is drunk water, and discharges rare yellow green or white feces, severe contamination around the anus, the visible eyelid swelled that has is shed tears, or the generation dyspnea, dead preceding serious depleted, the beak cyanosis, the visible nervous symptoms that has, mortality rate is about 5%.The duck that dies of illness mainly shows as enteritis, and intestinal mucosa swelling is hemorrhage, and liver surface has syringe needle big canescence necrosis region or petechia, the darker in color redness, and bile is full, and the liver surface that has covers one deck canescence fibrinous exudate.The serious visible pericarditis weak yellow liquid of case, myocardial surface is coarse, and lung is pale red or the change of pulmonary consolidation liver occurs, and the cystose exudate is arranged in the trachea.It is bronze-colored that spleen is, splanchnocoel fibrinous exudate that organ surface covers usually with the thoracic wall adhesion.Be diagnosed as colibacillosis through clinical symptoms, pathological change and laboratory diagnosis.300 mesh sieves and mixing are pulverized, crossed to the Chinese medicine composition of getting embodiment 5; Undertaken by 1.0% amount of getting of material feeding amount to boil water, liquid medicine drinking-water, the medicinal residues spice is used in conjunction after 5 days an ill duck symptom complete obiteration of 97%, does not see repeatedly in 7 days that disease must heal.
Concrete case 6
In October, 2011,2000 meat geese of the Yin of Zhoukou City raising are in 17 age in days sudden onset.Sick goose spirit is depressed, and the feather pine disorderly is afraid of cold, often be extruded into a pile, constantly scream, fervescence, higher 1～2 ℃ than normal goose, feces is thin and stench is mixed with the blood streak, clot and bubble, crissum is stained with feces, appetite is useless exhausted, and thirsty desire increases dyspnea, last depletion is choked to death and is died mortality rate about 10%.The goose that dies of illness is cutd open the inspection variation and mainly shows as fibrinous pericarditis, airsacculitis, perihepatitis.Be diagnosed as colibacillosis through clinical symptoms, pathological change and laboratory diagnosis.300 mesh sieves and mixing are pulverized, crossed to the Chinese medicine composition of getting embodiment 6; Undertaken by 1.5% amount of getting of material feeding amount to boil water, liquid medicine drinking-water, the medicinal residues spice is used in conjunction 5 days, (oral drinking-water 50mg/L), is used in conjunction 3 days to use florfenicol solution simultaneously; The symptom complete obiteration of 97% ill goose does not see repeatedly in 7 days that disease must heal after 5 days.
Claims (2)
1. the Chinese herbal feed additive of prevention and treatment colibacillosis is characterized in that described feed additive mainly is made up of the following weight parts component: Rhizoma Coptidis 10-20 part, Cortex Phellodendri 10-20 part, Flos Chrysanthemi Indici 15-20 part, Cortex Moutan 15-20 part.
Prevention as claimed in claim 1 and the treatment colibacillosis Chinese herbal feed additive, it is characterized in that, in weight portion, described feed additive also comprises: Herba Lophatheri 10-15 part, Radix Paeoniae Rubra 10-15 part, Radix Scutellariae 10-15 part, Herba Houttuyniae 10-15 part, Spica Prunellae 15-20 part and Rhizoma Dryopteris Crassirhizomatis 10-15 part.
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| CN201310110310.4A CN103202908B (en) | 2013-04-01 | 2013-04-01 | Chinese herbal medicine feed additive for preventing and curing colibacillosis |
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| CN103202908B CN103202908B (en) | 2014-12-17 |
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| CN106107250A (en) * | 2016-06-06 | 2016-11-16 | 安康学院 | A kind of Bombyx mandarina feedstuff and preparation method thereof |
| CN106819622A (en) * | 2016-12-15 | 2017-06-13 | 新昌县柏克动物饲料技术开发有限公司 | Prevent and treat the feed addictive of mink colibacillosis |
| CN107184785A (en) * | 2017-05-04 | 2017-09-22 | 河北工程大学 | A kind of medicine for preventing and treating rabbit E.coli disease |
| CN115381918A (en) * | 2022-08-01 | 2022-11-25 | 郑州大学第二附属医院 | Traditional Chinese medicine composition for treating colibacillosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106107250A (en) * | 2016-06-06 | 2016-11-16 | 安康学院 | A kind of Bombyx mandarina feedstuff and preparation method thereof |
| CN106819622A (en) * | 2016-12-15 | 2017-06-13 | 新昌县柏克动物饲料技术开发有限公司 | Prevent and treat the feed addictive of mink colibacillosis |
| CN107184785A (en) * | 2017-05-04 | 2017-09-22 | 河北工程大学 | A kind of medicine for preventing and treating rabbit E.coli disease |
| CN115381918A (en) * | 2022-08-01 | 2022-11-25 | 郑州大学第二附属医院 | Traditional Chinese medicine composition for treating colibacillosis |
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| Publication number | Publication date |
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| CN103202908B (en) | 2014-12-17 |
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Inventor after: Chen Pengju Inventor after: Liu Yan Inventor after: Gong Ting Inventor after: Wang Rudu Inventor after: Hu Mei Inventor after: Han Fei Inventor after: Sun Bingli Inventor after: Gao Xupu Inventor after: Xie Jinhui Inventor before: Chen Pengju |
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Free format text: CORRECT: INVENTOR; FROM: CHEN PENGJU TO: CHEN PENGJU LIU YAN GONG TING WANG RUDOU HU MEI HAN FEI SUN BINGLI GAO XUPU JIE JINHUI |
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Effective date of registration: 20170122 Address after: 530104 the Guangxi Zhuang Autonomous Region Nanning Yilin Industrial Zone No. B-9 Patentee after: GUANGXI NANNING TAOYUAN VETERINARY DRUG FACTORY Address before: 450002, Henan Province, Zhengzhou cultural North Road, building 50, No. 9 Patentee before: Chen Pengju |
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