CN103479691B - Fat-reducing liver-protecting Chinese medicine composition - Google Patents
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Abstract
The invention discloses a kind of fat-reducing liver-protecting Chinese medicine composition, belong to technical field of traditional Chinese medicine.Fat-reducing liver-protecting Chinese medicine composition disclosed by the invention is medicament, health product or the food made for raw material with Radix Bupleuri stem and leaf, the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis.Show through clinical verification, Chinese medicine composition life-time service of the present invention can hepatoprotective, vessel softening, blood fat reducing, to mid-aged population because of fatty liver caused by glucose-lipid metabolism disorder, hyperlipidemia, the symptoms such as sclerosis of blood vessels and disease have significant preventive and therapeutic action.
Description
Technical field
The invention discloses a kind of fat-reducing liver-protecting Chinese medicine composition, belong to food, health product or the field of Chinese medicines.
Background technology
Modern way of life changes the physical and mental health that the metabolic disease caused has had a strong impact on people, and cause great burden on society, increasing people suffers from glucose-lipid metabolism disorder disease, and middle-aged and elderly people is particularly serious.Modern medicine thinks that glucose-lipid metabolism disorder is the major pathologic features of metabolism syndrome, also be the key element of multiple risk factors in metabolism syndrome, it is pathologic basis and the main risk factor of apoplexy, coronary heart disease, myocardial infarction and other multiple chronic disease, modal have hyperlipidemia, diabetes, fatty liver, hypertension, impaired glucose tolerance (IGI), fasting glucose impairment (IFG) etc., for its prevention and therapy, medical circle not yet has the significant medicine of therapeutical effect.
The traditional Chinese medical science is thought, the category such as glucose-lipid metabolism disorder relevant disease belongs to that the traditional Chinese medical science is quenched one's thirst, the thoracic obstruction, cardiopalmus, headache, dizzy, phlegm-damp, main pathogenesis is the liver failing to maintain the normal flow of QI, causes visceral dysfunction, and body fluid loses the syndrome caused in defeatedization.Liver controlling conveyance and dispersion, catharsis is " dredging ", " happy ", the meaning of " bar reaches ", and that is, under normal physiological condition, irritability has dredging, the characteristic that bar reaches, and this function is mainly reflected in the dredging of liver to mechanism of qi, " mechanism of qi " the i.e. ascending, descending, exiting and entering motion of gas.The activity such as internal organs, meridians, organ of body, relies the ascending, descending, exiting and entering in gas to move entirely.And the physiological characteristics of liver is main liter, initiatively, so, this dredging for mechanism of qi, fluent, rise and send out a beyond doubt important factor.Therefore, whether the catharsis function of liver normal, for gas ascending, descending, exiting and entering between balance coordination play a part adjustment.Blood-fat and blood sugar is just as nutrient blood body fluid, and be the cereal nutrient that water paddyization is raw, the catharsis function of liver is normal, then QI movement being in harmonious way, and lifting is suitable, and QI and blood and tune, meridians tonneau, internal organs organ dysfunction is normal.Essence of water and grain concentrates blood vessels on, warm skin, moistens foster internal organs bones of the body collectively.Surfeit delicious food pure wine savoury, sitting lying on bed for a long time damage temper, the loose essence of spleen, vital essence can not on be attributed to lung and towards hundred arteries and veins, water paddy elite is detained and is not changed, soil plug wood is strongly fragrant, strongly fragrant and heat-transformation, consumption impairment of QI Tianjin, clear QI failing to ascend, turbid YIN failing to descend, accumulatively wet raise phlegm, stays and forms the stasis of blood, expectorant is turbid, blood stasis checks meridians internal organs and causes blood pressure and blood lipoid to raise, and this is the Basic disease cause pathogenesis of glucose-lipid metabolism disorder relevant disease.Therefore, soothing the liver nourishing blood to suppress the hyperactive liver, promoting flow of QI and blood blood stasis dispelling, changes base therapy and Precautionary Principle that turbid blood fat reducing eliminating dampness by diuresis is glucose-lipid metabolism disorder.
Traditional Chinese Medicine University Of Guangzhou Guo Jiao etc. also think that the crucial pathogenesis of metabolic disease is for " liver is lost pivot and uses ", propose theory and " the hinge hepatic metabolism regulating system " concept of " taking liver as pivot; adjust esterified turbid ", think liver to be hyperlipemia be the core of metabolic disease morbidity internal organs (liver spleen kidney) of representative and hinge, for the Chinese medicine prevention of metabolic disease provides thinking.
Therefore, soothing the liver nourishing blood to suppress the hyperactive liver, promoting flow of QI and blood blood stasis dispelling, changes the new direction that turbid blood fat reducing is treatment glucose-lipid metabolism disorder.Though Western medicine is instant effect in treatment glucose-lipid metabolism disorder disease, cure the symptoms, not the disease, toxic and side effects is large, increases new burden to patient, as: Simvastatin Treatment hyperlipemia lipid-lowering effect is fast, but has certain damaging action to liver function; Chinese herbal medicine specimen is double to be controlled, and toxic and side effects is little, in treatment glucose-lipid metabolism disorder disease, be more applicable to mid-aged population.So, provide a kind of and be extensively applicable to mid-aged population and can the Chinese medicine preparation of effective fat-reducing liver-protecting be a problem being worth studying.
Radix Bupleuri is large conventional Chinese medicine, and States Pharmacopoeia specifications Radix Bupleuri only has root just can be used as medicine, so the general root with Radix Bupleuri is used as medicine at present, its root has the effects such as antipyretic, analgesia, calmness, antiinflammatory.Generally believe that Radix Bupleuri all herbal medicine can reduce the quality of medicine, often Radix Bupleuri stem and leaf is abandoned as garbage so gather in the crops in the early spring.In recent years, carry out the pharmacological research to Radix Bupleuri stem and leaf both at home and abroad gradually, found that Radix Bupleuri stem and leaf has the effects such as enhancing immunity, antiviral, antiinflammatory, analgesia and antioxidation.Therefore Radix Bupleuri stem and leaf goes out of use, and not only causes the huge wasting of resources, also causes economic loss to peasant, is unfavorable for very much the development of Radix Bupleuri industry.
For the application of Radix Bupleuri stem and leaf in concrete medicine, also nobody relates to.And also have no at present both at home and abroad with Radix Bupleuri stem and leaf as primary raw material makes bibliographical information and the patent application of medicine, health product or food.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, change Radix Bupleuri industry now and Radix Bupleuri stem and leaf is utilized to situation about being not good at, make up the blank of Radix Bupleuri stem and leaf in medicinal application simultaneously, Radix Bupleuri stem and leaf is provided to prepare the application had in the Chinese medicine composition of fat-reducing liver-protecting effect, there is provided one further with Radix Bupleuri stem and leaf for one of main component, be widely used in mid-aged population to have actively and the hepatoprotective of sure effect, vessel softening, changes the Chinese medicine composition of turbid blood fat reducing.
In order to realize foregoing invention object, the technical solution used in the present invention is as follows:
A kind of fat-reducing liver-protecting Chinese medicine composition, it is medicament, health product or the food made for primary raw material with Radix Bupleuri stem and leaf.
Further, Radix Bupleuri stem and leaf can use with regulating one or more drug matchings of glycolipid metabolism, as: the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, the Radix Astragali, Ganoderma, Herba Taraxaci, Radix Puerariae, Rhizoma Curcumae Longae, Rhizoma Atractylodis, Folium Nelumbinis, Fructus Chaenomelis, Herba Apocyni veneti, Radix Achyranthis Bidentatae, Fructus Gardeniae, Fructus Lycii, Flos Chrysanthemi, Radix Rehmanniae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Os Draconis, Concha Ostreae, Concha Margaritifera, Carapax et Plastrum Testudinis, Radix Scutellariae, Fructus Liquidambaris, Concha Haliotidis, Spica Prunellae etc.
Further, Radix Bupleuri stem and leaf of the present invention is the tender point of Radix Bupleuri.
Fat-reducing liver-protecting Chinese medicine composition provided by the invention, raw material also comprises Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis.
Best, fat-reducing liver-protecting Chinese medicine composition of the present invention, raw material also comprises the Radix Paeoniae Alba, Radix Glycyrrhizae.This Chinese medicine composition altogether for monarch drug, with Fructus Crataegi, Radix Salviae Miltiorrhizae altogether for ministerial drug, take Rhizoma Alismatis as adjuvant drug, with Radix Glycyrrhizae for making medicine with Radix Bupleuri stem and leaf, the Radix Paeoniae Alba.Folium Bupleuri 5 Radix Paeoniae Alba, dispersing the stagnated live-QI to relieve the stagnation of QI, nourishing blood to suppress the hyperactive liver, Fructus Crataegi circulation of qi promoting dissipating blood stasis, changes turbid blood fat reducing, Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, and clear away heart-fire relieving restlessness, and Rhizoma Alismatis promoting diuresis to eliminate damp pathogen, expels the heat-evil, and changes turbid blood fat reducing, Radix Glycyrrhizae heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.All medicines share, and have significant fat-reducing liver-protecting effect.
Further, in above-mentioned fat-reducing liver-protecting Chinese medicine composition, the weight portion of each raw material is: Radix Bupleuri stem and leaf 10-50 part, Radix Paeoniae Alba 8-30 part, Radix Glycyrrhizae 2-15 part, Fructus Crataegi 20-60 part, Radix Salviae Miltiorrhizae 20-60 part, Rhizoma Alismatis 2-12 part.
Preferably, in fat-reducing liver-protecting Chinese medicine composition of the present invention, the weight portion of each raw material is: Radix Bupleuri stem and leaf 12-40 part, Radix Paeoniae Alba 9-20 part, Radix Glycyrrhizae 3-10 part, Fructus Crataegi 25-45 part, Radix Salviae Miltiorrhizae 25-45 part, Rhizoma Alismatis 5-10 part.
Preferred, in fat-reducing liver-protecting Chinese medicine composition of the present invention, the weight portion of each raw material is: Radix Bupleuri stem and leaf 15-30 part, Radix Paeoniae Alba 10-15 part, Radix Glycyrrhizae 4-8 part, Fructus Crataegi 27-35 part, Radix Salviae Miltiorrhizae 26-40 part, Rhizoma Alismatis 7-9 part.
Most preferably, in fat-reducing liver-protecting Chinese medicine composition of the present invention, the weight portion of each raw material is: Radix Bupleuri stem and leaf 20 parts, the Radix Paeoniae Alba 12 parts, 5 parts, Radix Glycyrrhizae, Fructus Crataegi 30 parts, Radix Salviae Miltiorrhizae 30 parts, Rhizoma Alismatis 8 parts.
Radix Bupleuri stem and leaf is preparing the application had in the Chinese medicine composition of fat-reducing liver-protecting effect.
The medicament of fat-reducing liver-protecting Chinese medicine composition of the present invention, health product or food, can be processed through extraction or other modes by the raw material that above-mentioned formula is formed, make pharmaceutically active substance, with this material for raw material, add medicine, health product or food acceptable carrier or adjuvant when needing, conveniently technology is made.Described active substance can obtain by extracting raw material respectively, also can be obtained by the common raw material that extracts, also can obtain by other means, as: by pulverizing, squeezing, grind, sieve, extract, the method such as water extraction, alcohol extraction, ester carry, chromatography obtains, these active substances can be the materials of extractum form, can be dry extract also can be fluid extract, need to determine to make different concentration according to the difference of preparation.
Fat-reducing liver-protecting Chinese medicine composition of the present invention, its pharmaceutically active substance is through that to extract processing obtained, and processing can adopt any combination in said method.
A kind of preparation method of fat-reducing liver-protecting Chinese medicine composition of the present invention, comprises the following steps:
(1) Radix Bupleuri stem and leaf is taken in proportion, the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis;
(2) raw material in step (1) is prepared into extract or crude drug powder in the following manner:
A) extract or crude drug powder is prepared into respectively,
B) one or more mixed raw materials standby one-tenth extract or crude drug powder,
C) whole mixed raw material standby one-tenth extract or crude drug powder;
(3) by the extract of gained raw material in step (2) or the mixing of crude drug powder, acceptable various pharmaceutical dosage form, health product or food is made.
Further, in the preparation method of fat-reducing liver-protecting Chinese medicine composition of the present invention, step (2) comprising: get the Radix Bupleuri stem and leaf in step (1), the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, mixing, extracts, obtains extract.
Fat-reducing liver-protecting Chinese medicine composition of the present invention conveniently technique adds customary adjuvant or carrier and can make one or more products such as decoction, medicinal tea, beverage, oral liquid, mixture, granule, capsule, tablet, syrup, buccal tablet, chewable tablet, electuary, pill, drop pill or injection and use.Such as, take Radix Bupleuri stem and leaf in proportion, the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, pulverized by above-mentioned raw materials, mix homogeneously, every part of health paper bag of making tea by a certain amount of loading, after sealing, packaging, namely makes medicinal tea; Or take Radix Bupleuri stem and leaf in proportion, the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, mix homogeneously, adopt decocting cooking method to extract thick paste, drying under reduced pressure, pulverize, obtain dry extract, add adjuvant, mix homogeneously, granulate, encapsulated, obtain capsule.
Compared with prior art, the invention has the beneficial effects as follows:
Fat-reducing liver-protecting Chinese medicine composition of the present invention, provide a kind of Chinese medicine composition being one of constituent with Radix Bupleuri stem and leaf, achieve the comprehensive utilization of Radix Bupleuri, compensate for Radix Bupleuri stem and leaf medicinal application in blank, compositions hepatoprotective of the present invention, vessel softening, lipid-lowering effect is remarkable, and side effect is little, to mid-aged population because of fatty liver caused by glucose-lipid metabolism disorder, hyperlipidemia, the symptoms such as sclerosis of blood vessels and disease have significant preventive and therapeutic action.And show through clinical observation, its total effective rate reaches 98.18%.
Fat-reducing liver-protecting Chinese medicine composition of the present invention both can make health product, food, can make medicine again, had greatly expanded the scope of application.Medicine material of the present invention all easily obtains from the market, and preparation method is simple, has very strong application value.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
Following embodiment and experimental technique, if no special instructions, be conventional method; Described reagent and medicine, if no special instructions, all can obtain from commercial channels.
Embodiment 1 medicinal tea
Radix Bupleuri stem and leaf 10g, Radix Paeoniae Alba 8g, Radix Glycyrrhizae 5g, Fructus Crataegi 20g, Radix Salviae Miltiorrhizae 20g, Rhizoma Alismatis 8g, pulverized by above-mentioned raw materials, mix homogeneously, every part of 5g loads the health paper bag of making tea, and after sealing, packaging, namely makes medicinal tea.
Embodiment 2 beverage
Radix Bupleuri stem and leaf 30g, Radix Paeoniae Alba 15g, Radix Glycyrrhizae 10g, Fructus Crataegi 40g, Radix Salviae Miltiorrhizae 40g, Rhizoma Alismatis 10g, mix homogeneously, adopts decocting cooking method to extract thick paste, drying under reduced pressure, pulverizes, obtain dry extract.
Get above-mentioned dry extract, routinely process, namely comprise the steps such as allotment-homogenizing-degassed-pasteurize-fill-cooling, can finished beverage be obtained.
Embodiment 3 capsule
Radix Bupleuri stem and leaf 40g, Radix Paeoniae Alba 20g, Radix Glycyrrhizae 15g, Fructus Crataegi 50g, Radix Salviae Miltiorrhizae 40g, Rhizoma Alismatis 12g, mix homogeneously, adopts decocting cooking method to extract thick paste, drying under reduced pressure, pulverizes, obtain dry extract.
Get above-mentioned dry extract, conveniently technique adds Pulvis Talci, starch, mix homogeneously, granulates, encapsulated, obtains capsule.
Embodiment 4 tablet
Radix Bupleuri stem and leaf 50g, Radix Paeoniae Alba 20g, Radix Glycyrrhizae 15g, Fructus Crataegi 60g, Radix Salviae Miltiorrhizae 60g, Rhizoma Alismatis 12g, mix homogeneously, adopts decocting cooking method to extract thick paste, drying under reduced pressure, pulverizes, obtain dry extract.
Get above-mentioned dry extract, conveniently technique adds calcium carbonate, starch, mix homogeneously, and tabletting obtains tablet.
Embodiment 5 oral liquid
Radix Bupleuri stem and leaf 25g, Radix Paeoniae Alba 12g, Radix Glycyrrhizae 5g, Fructus Crataegi 30g, Radix Salviae Miltiorrhizae 30g, Rhizoma Alismatis 8g, mix homogeneously, adopts decocting cooking method to extract thick paste, drying under reduced pressure, pulverizes, obtain dry extract.
Get above-mentioned dry extract, conveniently technique is dissolved in water, adjust ph, adds solubilizing agent, antiseptic, correctives, fill, makes oral liquid.
Embodiment 6 granule
Radix Bupleuri stem and leaf 35g, Radix Paeoniae Alba 12g, Radix Glycyrrhizae 5g, Fructus Crataegi 30g, Radix Salviae Miltiorrhizae 30g, Rhizoma Alismatis 8g, mix homogeneously, adopts decocting cooking method to extract thick paste, drying under reduced pressure, pulverizes, obtain dry extract.
Get above-mentioned dry extract, conveniently technique adds dextrin, cane sugar powder, and mixing, adds appropriate 90% ethanol, make granule.
Embodiment 7 decoction
Radix Paeoniae Alba 12g, Radix Glycyrrhizae 5g, Fructus Crataegi 30g, Radix Salviae Miltiorrhizae 30g, Rhizoma Alismatis 8g, container is put in mixing, add suitable quantity of water, decoct to water boiling, after 5 ~ 10 minutes, add Radix Bupleuri stem and leaf 20g, again decoct 5 ~ 10 minutes, total decocting time is about 20 ~ 30 minutes, removes solid residue, can obtain decoction of the present invention.
Experimental example 1
1. case selection standard
1.1 tcm syndrome differentiation and typing standards: the liver failing to maintain the normal flow of QI, visceral dysfunction, body fluid loses the qi stagnation and blood stasis type in defeatedization.Card is shown in dizziness headache, fullness and distention in the chest and hypochondrium or twinge, palpitation and uneasiness, vertigo and tinnitus, or companion's excessive thirst polydipsia, emotion irritability, or fat or become thin, purplish tongue, stringy and hesitant pulse.Lab testing TC, TG exceed normal value more than 10%, abnormal liver function, and liver ultrasound is shown in fatty pathological changes.
1.2 inclusive criterias: according to tcm diagnosis standard diagnostics be the thoracic obstruction, cardiopalmus, headache, dizzy, the sick patient occurring qi depression to blood stasis symptom such as quench one's thirst.Hyperlipemia meets the hyperlipemia diagnostic criteria that State Administration of Traditional Chinese Medicine's " guideline of clinical investigations of new Chinese medicine treatment hyperlipemia " formulates, Diagnosis of Fatty liver standard during Diagnosis of Fatty liver standard meets " up-to-date domestic and international Disease Diagnosis Standard ".Its complication state of an illness of Complicated with Hypertension, diabetes, patients with coronary heart disease should be in stable phase.The range of age is in 25-76 year; Therapist can be adhered to the course for the treatment of according to plan.
1.3 exclusion standards: do not meet the above-mentioned traditional Chinese medical science thoracic obstruction, cardiopalmus, headache, dizzy, qi stagnation and blood stasis type symptom of the quenching one's thirst person of description, the age is less than 25 years old or is greater than 76 years old person; Modern medicine is not diagnosed as fatty liver, hyperlipemia, and Complicated with Hypertension, diabetes, its complication state of an illness of patients with coronary heart disease do not stablize person.
1.4 reject standard: do not complete person's course for the treatment of; The terminator because of serious adverse reaction.
2. clinical observation
In year June certain traditional Chinese medical science Grade A hospital in July, 2003 to 2011 consulting patients in out-patient department, choose the patient that 1355 examples meet above-mentioned inclusive criteria.Random point of three groups of observation, treatment group 660 is routine, age 25-75 year, the mean age (45.6 ± 2.5) year, male patient 396 people, female patient 264 people, course of disease 2-30, average course of disease (16.2 ± 1.4) year; Wherein, Patients with Fatty Liver 325 example, hyperlipemia 335 example, complicated with hypertension 111 example, complicated with diabetes patient 55 example, concurrent patients with coronary heart disease 52 example.
Matched group 1 example, age 26-76 year, the mean age (46.2 ± 2.1) year, male patient 389 people, female patient 271 people, course of disease 3-31, average course of disease (16.5 ± 1.7) year; Wherein, Patients with Fatty Liver 331 example, hyperlipemia 329 example, complicated with hypertension 108 example, complicated with diabetes patient 57 example, concurrent patients with coronary heart disease 51 example.
Matched group 2 35 example, the mean age (45.6 ± 2.5) year, male patient 20 people, female patient 15 people, course of disease 2-30, average course of disease (16.2 ± 1.4) year; Wherein, Patients with Fatty Liver 15 example, hyperlipemia 5 example, complicated with hypertension 11 example, complicated with diabetes patient 5 example, concurrent patients with coronary heart disease 12 example.
Between three groups in age, the course of disease, severity extent, extent of disease, symptom etc. without marked difference (P > 0.05), there is comparability.
3. Therapeutic Method
Treatment group: select decoction of the present invention (according to the preparation of embodiment 7 method) to take, 1 dose/day, sooner or later respectively once, after taking January, uses medicinal tea instead and continues to take two months, each 5g, and every day, boiled water was taken after being infused in hot water or decoction three guarantees.Treatments period is stopped using other antihyperglycemic hepatoprotective agent, but Complicated with Hypertension, diabetes, patients with coronary heart disease, add corresponding chemical medicine respectively.Advise patient's daily life rule, moderate exercise, does not stay up late, and non-smoking does not drink, and does not eat greasy food, eats the vegetable and fruit of being rich in vitamin more.
Matched group one: Patients with Fatty Liver, takes polyene phosphatidylcholine capsule, and each 2 (456mg), every day 3 times, take three months; Hyperlipemia, takes Simvastatin Tablets, every day 20mg, night every day takes once, takes three months.Treatments period is stopped using other antihyperglycemic hepatoprotective agent, but Complicated with Hypertension, diabetes, patients with coronary heart disease, add the chemotherapeutic agent same with treatment group respectively.Advise patient's daily life rule, moderate exercise, does not stay up late, and non-smoking does not drink, and does not eat greasy food, eats the vegetable and fruit of being rich in vitamin more.
Matched group two: use the decoction oral that boils of compositions lacking Radix Bupleuri stem and leaf, 1 dose/day, sooner or later each once, after taking one month, continuation is made tea without the medicinal tea that the compositions of Radix Bupleuri stem and leaf is made and is taken two months, each 5g, and every day, boiled water was taken after being infused in hot water or decoction three guarantees.Treatments period is stopped using other antihyperglycemic hepatoprotective agent, but Complicated with Hypertension, diabetes, patients with coronary heart disease, add corresponding chemotherapeutic agent respectively.Advise patient's daily life rule, moderate exercise, does not stay up late, and non-smoking does not drink, and does not eat greasy food, eats the vegetable and fruit of being rich in vitamin more.
4. efficacy assessment standard
Hyperlipemia is according to the curative effect determinate standard of State Administration of Traditional Chinese Medicine's " new Chinese medicine treatment hyperlipemia guideline of clinical investigations ".Clinical cure: clinical symptoms, sign disappear, the every inspection of laboratory recovers normal; Effective: clinical symptoms, sign disappear substantially, lipids detection reaches following any one person, i.e. TC index rate of descent >=20%, TG index rate of descent >=40% or HDL-C index >=0.26mmol/L; Effective: lipids detection reaches following any one person, i.e. TC index rate of descent >=10% < 20%, TG index rate of descent >=20% < 40% or HDL-C index >=0.104mmol/L < 0.26mmol/L simultaneously simultaneously simultaneously; Invalid: after treatment, symptom, sign and lipids detection are not improved.
Fatty liver is with reference to the criterion of " clinical disease diagnosis is according to curing improvement standard ".Clinical cure: fatty liver disappears, and TC, TG, liver power recovery are normal; Effective: fatty liver is clearly better, TC, TG, liver function are obviously improved; Effective: fatty liver take a favorable turn, TC, TG, liver function are all improved but not remarkable; Invalid: fatty liver, blood fat, liver function are unchanged.
Total effective rate=(clinical cure+effective+effectively)/total number of cases * 100%.
5. statistical method
Enumeration data represents with percentage rate (%), compares and adopt X2(X square between group) inspection, P < 0.05 has statistical significance for difference.Concrete numerical value and the results are shown in Table 1.
Table 1, treatment group and matched group Clinical efficacy comparison
Note: compare with matched group one, matched group two, P < 0.05
6. result
As shown in Table 1, treatment group total effective rate is 98.18%, higher than the total effective rate 71.42% of matched group one total effective rate 91.06% and matched group two, difference has statistical significance (P < 0.05), and the visible effect of the present composition that uses is better than using the effect of Western medicine and use to lack the effect of the compositions of Radix Bupleuri stem and leaf.Experimental result illustrates fatty liver, hyperlipemia caused by glucose-lipid metabolism disorder, and Complicated with Hypertension, diabetes, coronary heart disease but the patient of complication stable disease, better with the Chinese medicine preparation conditioning effect of formula of the present invention, treat also more comprehensive.Polyene phosphatidyl choline for treating fatty liver liver protective effect is good, but lipid-lowering effect is general; Simvastatin Treatment hyperlipemia lipid-lowering effect is good, but has certain damaging action to liver function; And the present composition considers for etiology and pathogenesis, reinforce insufficiency and reduce excessiveness, soothing the liver nourishing blood to suppress the hyperactive liver, promoting flow of QI and blood blood stasis dispelling, change turbid blood fat reducing eliminating dampness by diuresis, toxic and side effects is little, is applicable to very much mid-aged population to the prevention of above-mentioned disease, and the treatment of morbidity rear stable disease phase.Also show that in Radix Bupleuri stem and leaf and the present composition, all the other components have obvious synergistic function, three groups all there is not obvious adverse reaction simultaneously.
Claims (6)
1. a fat-reducing liver-protecting Chinese medicine composition, is characterized in that, described Chinese medicine composition is medicament, health product or the food be made up of following raw material:
Radix Bupleuri stem and leaf 10-50 part, Radix Paeoniae Alba 8-30 part, Radix Glycyrrhizae 2-15 part, Fructus Crataegi 20-60 part, Radix Salviae Miltiorrhizae 20-60 part, Rhizoma Alismatis 2-12 part.
2. fat-reducing liver-protecting Chinese medicine composition according to claim 1, is characterized in that, in Chinese medicine composition, the weight portion of each raw material is: Radix Bupleuri stem and leaf 12-40 part, Radix Paeoniae Alba 9-20 part, Radix Glycyrrhizae 3-10 part, Fructus Crataegi 25-45 part, Radix Salviae Miltiorrhizae 25-45 part, Rhizoma Alismatis 5-10 part.
3. fat-reducing liver-protecting Chinese medicine composition according to claim 2, is characterized in that, in Chinese medicine composition, the weight portion of each raw material is: Radix Bupleuri stem and leaf 15-30 part, Radix Paeoniae Alba 10-15 part, Radix Glycyrrhizae 4-8 part, Fructus Crataegi 27-35 part, Radix Salviae Miltiorrhizae 26-40 part, Rhizoma Alismatis 7-9 part.
4. fat-reducing liver-protecting Chinese medicine composition according to claim 3, is characterized in that, in Chinese medicine composition, optimum weight part of each raw material is: Radix Bupleuri stem and leaf 20 parts, the Radix Paeoniae Alba 12 parts, 5 parts, Radix Glycyrrhizae, Fructus Crataegi 30 parts, Radix Salviae Miltiorrhizae 30 parts, Rhizoma Alismatis 8 parts.
5. the fat-reducing liver-protecting Chinese medicine composition according to any one of claim 1-4, is characterized in that: described medicament, health product or food are decoction, medicinal tea, beverage, oral liquid, mixture, granule, capsule, tablet, syrup, pill, drop pill or injection.
6. a kind of preparation method of the fat-reducing liver-protecting Chinese medicine composition according to any one of claim 1-4, comprises the following steps:
(1) Radix Bupleuri stem and leaf, the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis is taken in proportion;
(2) raw material in step (1) one of is in the following manner prepared into extract or crude drug powder:
A) extract or crude drug powder is prepared into respectively,
B) one or more mixed raw materials standby one-tenth extract or crude drug powder,
C) whole mixed raw material standby one-tenth extract or crude drug powder;
(3) by the extract of gained raw material in step (2) or the mixing of crude drug powder, acceptable various pharmaceutical dosage form, health product or food is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310460542.2A CN103479691B (en) | 2013-09-30 | 2013-09-30 | Fat-reducing liver-protecting Chinese medicine composition |
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| CN104042803A (en) * | 2014-07-15 | 2014-09-17 | 董宝珍 | Traditional Chinese medicinal liquor for treating hyperlipemia and brewing method thereof |
| CN104225115B (en) * | 2014-09-29 | 2018-01-09 | 上海市青浦区中医医院 | A kind of medicine for treating fatty liver and its application |
| CN105169215A (en) * | 2015-07-15 | 2015-12-23 | 济南大学 | Traditional Chinese medicine composition for treating alcoholic fatty liver |
| CN106421562A (en) * | 2016-11-04 | 2017-02-22 | 张超英 | Enzyme-reducing and liver-protecting traditional Chinese medicinal composition and preparation method of traditional Chinese medicine decoction |
| CN106721812A (en) * | 2016-12-19 | 2017-05-31 | 河北林益堂药业有限公司 | The preparation method of radix bupleuri beverage |
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| CN1528759A (en) * | 2003-09-29 | 2004-09-15 | 江苏省中国科学院植物研究所 | Radix bupleuri stem-leaf extract and preparing method and use thereof |
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