CN1939506B - Preparation with blood-pressure, blood-sugar and blood-fat lowering functions and its making method - Google Patents
Preparation with blood-pressure, blood-sugar and blood-fat lowering functions and its making method Download PDFInfo
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- CN1939506B CN1939506B CN2006100944437A CN200610094443A CN1939506B CN 1939506 B CN1939506 B CN 1939506B CN 2006100944437 A CN2006100944437 A CN 2006100944437A CN 200610094443 A CN200610094443 A CN 200610094443A CN 1939506 B CN1939506 B CN 1939506B
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Abstract
A Chinese medicine in the form of oral liquid or others for preventing diabetes and its complication, hyperlipemia, hypertension, retinosis and cardiovascular disease is prepared from 9 Chinese-medicinal materials including ginseng, wolfberry fruit, red sage root, pueraria root, etc. Its preparing process is also disclosed.
Description
1. technical field
The preparation that the present invention relates to a kind of blood sugar lowering, blood fat reducing, blood pressure lowering, makes eye bright, specifically the Chinese herbal medicine with " integration of edible and medicinal herbs " is the article of feedstock production.The invention still further relates to the preparation method of these article.
2. background technology
Hyperglycemia, hyperlipidemia, hypertension claim " three-hypers disease ", Chang Bingfa retinopathy.Studies show that the patient causes sugar, fat, protein metabolism disorder owing to insulin in the blood lacks relatively or definitely, dysarteriotony causes atherosclerosis and microcirculation disturbance, and hemodynamics changes, fibrinolytic system and platelet function abnormality are assembled, and blood stasis is detained.The health protection with Chinese medicine theory is thought mainly by due to the deficiency of vital energy, the deficiency of YIN, belong to " turbid yin ", " phlegm-damp " categories such as " damp and hot ", the blood stasis due to two void can block mechanism of qi, and body fluid loses in defeated cloth, channels stasis of blood resistance (little blood vessel, neuropathy) is so multiple complications occurs.
Both at home and abroad to the primary disease Drug therapy, run into following technical barrier at present:
1. Western medicine class (as Statins, two flesh class, iodine ureas, insulin etc.) is effective, but side effect is big, and is with infringement liver, kidney and hemocyte, invalid to complication for a long time.
2. the effect of Chinese patent medicine class is slow, and effect is not fairly obvious.
3. retinopathy lacks effective medicine at present.
3. summary of the invention:
The preparation that the purpose of this invention is to provide a kind of blood sugar lowering, blood fat reducing, blood pressure lowering, makes eye bright.
Another object of the present invention provides the preparation method of said preparation.
The present invention is to " three-hypers disease " and pathogenetic understanding of complication and Therapeutic Principle according to Chinese medicine and pharmacy, with reference to modern pharmacological research achievement and advanced technologies, from the plant amedica of " integration of edible and medicinal herbs ", filter out supplementing QI and nourishing YIN, blood sugar lowering, blood fat reducing, blood pressure lowering, blood circulation and channel invigorating, make eye bright, can improve the medical material of blood microcirculation flow and immunity, by the tcm health preserving theoretical prescription that keeps healthy, skim the cream off milk with modern advanced technologies, make the integrally-regulated and blood circulation and channel invigorating of its performance, the all methods such as blood flow and immunity that improve cooperate, promote endogenous secretion of insulin, reduce exogenous insulin periphery drag, effective blood sugar regulation, in the time of metabolism disorder of blood lipid, microcirculation improvement brings high blood pressure down, the relieving retina pathological changes.
Article of the present invention are made (consumption is a weight) by following component:
10-25 parts of 15-25 parts of Fructus Lycii of 10-30 parts of Fructus Ligustri Lucidi of Radix Ginseng
20-30 parts of 10-20 parts of Radix Puerariaes of 10-20 parts of Radix Salviae Miltiorrhizaes of Fructus Schisandrae Chinensis
10-30 portions of Fructus Jujubaes of 20-35 parts of Rhizoma Polygonatis of Semen Cassiae 10---25 parts
The formula optimization weight proportion scope of preparation article of the present invention is:
6-15 parts of 6-20 parts of Fructus Lycii of 3-10 parts of Fructus Ligustri Lucidi of Radix Ginseng
9-25 parts of 5-15 parts of Radix Puerariaes of 1.5-10 parts of Radix Salviae Miltiorrhizaes of Fructus Schisandrae Chinensis
6-15 parts in 9-25 portions of Fructus Jujubaes of 8-15 parts of Rhizoma Polygonatis of Semen Cassiae
The optimum weight proportioning of article of the present invention is:
8 parts of 10 parts of Fructus Lycii of 5 parts of Fructus Ligustri Lucidi of Radix Ginseng
10 parts of 12 parts of Radix Puerariaes of 3 parts of Radix Salviae Miltiorrhizaes of Fructus Schisandrae Chinensis
6 parts in 11 portions of Fructus Jujubaes of 15 parts of Rhizoma Polygonatis of Semen Cassiae
The production method that above-mentioned each component is made article of the present invention is:
1. Radix Ginseng, Fructus Ligustri Lucidi, Radix Salviae Miltiorrhizae is broken by above-mentioned prescription medical material mixed powder, make coarse powder, enable pass is crossed No. 1 sieve or No. 2 sieves, use alcohol reflux, filters, and alcohol extract is standby with gathering Pyrusussuriensis fat 80 solubilisings, and medicinal residues are preserved respectively.
2. with Fructus Lycii, Fructus Schisandrae Chinensis, Semen Cassiae, Radix Puerariae, Rhizoma Polygonati, Fructus Jujubae, be broken into coarse powder by above-mentioned prescription medical material mixed powder, add above-mentioned medicinal residues (after the alcohol extraction) and use the Multifunction tank decocting, extract volatile oil and medicinal liquid according to a conventional method.
3. the decocting medicinal liquid is clarified with zymotechnic, concentrated, filter.
4. volatile oil is handled with β-CD enclose;
5. add adjuvant (solubilizing agent, antiseptic, antioxidant) after alcohol extract, volatile oil, clathrate decocting medicinal liquid being cooperated and obtain dosing;
6. according to a conventional method the Chinese patent medicine dosage form is made in dosing again, as hard capsule, soft capsule, tablet, granule, powder, pill, teabag, medicated wine, oral liquid, (health product), distillate medicinal water, injection etc.; Also can be mixed and made into health food with the nutrition article.
An important feature of the present invention is to contain terpenes and flavonoid composition in the medicament, also contains total saponins, crude polysaccharides, oleanolic acid, terpenes total content 0.5%-1.0%, flavonoid total content 0.9%-1.8%.Wherein the terpenes composition has the effect of good blood sugar lowering cholesterol reducing.Contained flavone compound has very strong oxidation resistance, energy vessel softening, reduction vascular fragility, and microcirculation improvement can reduce too high blood fat, blood pressure, treatment of vascular sclerosis.The total saponins flavone compound has remarkable blood sugar decreasing effect, can increase the islets of langerhans blood perfusion, helps the synthetic and secretion of insulin; Platelet aggregation and thrombosis there are the good restraining effect, can blood circulation promoting and blood stasis dispelling, cleaning blood vessel, blood circulation promoting, raising blood flow; Crude polysaccharides has very strong defying age, strengthens the effect of body immunity.Contained oleanolic acid can effectively reduce the paddy transaminase.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
(1) to select natural edible-plant for use be raw material in the present invention, and each component meets the drug and food law regulation.Utilize the comprehensive function of prescription medicine to prevent and treat diabetes, hyperlipidemia, hypertension and complication, nontoxic, harmless to human body, also can be used as health food and use.
(2) select alcohol extracting method and use multi-functional extraction to irritate and extract active ingredient for use, the bioavailability height reaches quick-acting, purpose efficiently.
(3) contain oleanolic acid, liver is had protective effect, this is the characteristics of this prescription.
For showing the present invention to blood fat reducing, hypoglycemic activity effect, through the clinical observation of 100 routine systems, and selection medical history, the state of an illness, age, sex and suitable diabetes and hyperlipemic patients 50 examples of former Therapeutic Method are matched group.From being in hospital and endocrine special outpatient clinic selection case, press the diabetes diagnosis standard that WHO1980 formulates, the maturity-onset diabetes patient who makes a definite diagnosis, on the basis of Diet Therapy method and medicine (oral antidiabetic drug and insulin) treatment, fasting glucose 7.2mmol/L person is the object of observation, wherein male 48 examples, women 52 examples, 27-50 years old ages, course of disease half a year to 20 year.Test group, on former treatment basis, the lipid lowerers of stopping using is obeyed medicine of the present invention.Matched group: blood sugar lowering, blood fat reducing treatment routinely, wherein hypoglycemic medicine, kind instructions about how to take medicine consumption and test group are complementary, and lipid lowerers adopts the import fenofibrate.Adopt same procedure to make regular check on fasting glucose and blood fat, two months observation periods, 30 days is a course of treatment.
Instructions of taking: oral liquid 20ml/ of the present invention once, day clothes 3 times, ante cibum, boiled water was taken after mixing it with water.Clinical test results such as subordinate list 1-2.
Subordinate list 1 is taken medicine of the present invention front and back insulin, and diamicron is with being and change of blood sugar
Subordinate list 2 is taken medicine front and back lipid lowerers consumption of the present invention and the average concentration change of blood fat
From subordinate list 1 as can be seen, fasting glucose concentration is similar substantially with the hypoglycemic medicine consumption before two groups of tests, P＜0.05, and blood glucose descended after test group was taken the present invention, and the antidiabetic drug consumption is but than original minimizing 1/3-1/2.
Subordinate list 2 data show that serum cholesterol and triglyceride mean concentration do not have significant difference before two groups of tests; But test group is not used any other lipid lowerers with behind the article of the present invention, can reach the blood fat reducing purpose.Test statistics shows: with preparation of the present invention 100 diabetes and hyperlipemic patients are done therapeutic test, that obtains significant curative effect accounts for 53%, substantially effectively accounts for 42%, and invalid accounts for 5%, and total effective rate reaches 95%.For showing the action effect of the present invention,, undertaken by state food medicine Supervision Bureau health food functional evaluation method through the higher person of 100 people's blood pressures observation on probation to antihypertensive function.Instructions of taking: use oral liquid of the present invention 20ml/ time, day clothes 3 times, ante cibum, boiled water was taken after mixing it with water.Result of the test such as subordinate list 3.
Subordinate list 3
From subordinate list 3 as can be seen, systolic pressure on average descends 〉=20mmHg, and diastolic pressure on average descends 〉=10mmHg, or reduces to normal.Total effective rate is 93%.
4. the specific embodiment
Embodiment: take by weighing raw material by following proportioning
Radix Ginseng 5g Fructus Ligustri Lucidi 10g Fructus Lycii 8g
Fructus Schisandrae Chinensis 3g Radix Puerariae 10g Semen Cassiae 15g
Radix Salviae Miltiorrhizae 12g Rhizoma Polygonati 11g Fructus Jujubae 6g
Production method is shown in Figure of description:
Earlier Radix Ginseng, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi are mixed by above-mentioned prescription and pulverize, making can be by the coarse powder of No. 1 or No. 2 sieve, and with 75% ethanol (8 times of amounts) reflux, extract, 2 times, filtration, alcohol extract is standby with 0.2 poly-Pyrusussuriensis fat 80 solubilisings, and medicinal residues are preserved respectively; Again Fructus Lycii, Fructus Schisandrae Chinensis, Semen Cassiae, Radix Puerariae, Rhizoma Polygonati, Fructus Jujubae are broken into coarse powder by above-mentioned prescription mixed powder; Coarse powder is added 2 times of water loggings bubble 1 hour, add the medicinal residues after the alcohol extraction again, with " multi-function extractor " decocting 2 times, each 8 times of water extract volatile oil and medicinal liquid according to a conventional method, with medicinal liquid with the zymotechnic clarification after, make with supercentrifugal process and to fry in shallow oil the soup purification; With concentrated everyone the dose 20ml concentration at every turn that reaches of medicinal liquid; Dosing: the alcohol extract behind concentrated solution, volatile oil (β-CD enclose), the solubilising is mixed interpolation suitable antiseptic, antioxidant, correctives and solubilizing agent; The timely fill of the medicinal liquid for preparing in aseptic clean dried easy-open lid bottle (10ml/ props up), is added a cover obturation, 100 ℃ of flowing steam sterilization 30min.Make oral liquid.
Claims (4)
1. preparation that falls blood bran, blood fat reducing, blood pressure lowering is characterized in that it is the preparation of being made by following weight proportion raw material and method:
Radix Ginseng 3-10 part Fructus Ligustri Lucidi 6-20 part Fructus Lycii 6-15 part
Fructus Schisandrae Chinensis 1.5-10 part Radix Salviae Miltiorrhizae 5-15 part Radix Puerariae 9-25 part
Semen Cassiae 8-15 part Rhizoma Polygonati 9-25 part Fructus Jujubae 6-15 part
Radix Ginseng, Fructus Ligustri Lucidi, the Radix Salviae Miltiorrhizae mixing of said ratio are pulverized and made coarse powder, and with alcohol reflux, filtration, alcohol extract and medicinal residues are preserved respectively; Fructus Lycii, Fructus Schisandrae Chinensis, Radix Puerariae, Semen Cassiae, Rhizoma Polygonati, Fructus Jujubae mixed powder with said ratio is broken to coarse powder again, medicinal residues after the adding alcohol extraction, reuse " multi-function extractor " decocting extracts volatile oil and decocting medicinal liquid according to a conventional method, and medicinal liquid is clarified with zymotechnic; Again alcohol extract, volatile oil, decocting medicinal liquid are mixed the back and filter, add adjuvant, formulation method is prepared into required dosage form routinely.
2. preparation according to claim 1, wherein the weight proportion of each raw material is
8 parts of 10 parts of Fructus Lycii of 5 parts of Fructus Ligustri Lucidi of Radix Ginseng
10 parts of 12 parts of Radix Puerariaes of 3 parts of Radix Salviae Miltiorrhizaes of Fructus Schisandrae Chinensis
6 parts in 11 portions of Fructus Jujubaes of 15 parts of Rhizoma Polygonatis of Semen Cassiae.
3. preparation according to claim 1 and 2 is characterized in that said preparation is the above dosage form of saying of any pharmaceutics.
4. the described preparation of root a tree name claim 3 is characterized in that said preparation can be processed into health food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2006100944437A CN1939506B (en) | 2006-06-18 | 2006-06-18 | Preparation with blood-pressure, blood-sugar and blood-fat lowering functions and its making method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2006100944437A CN1939506B (en) | 2006-06-18 | 2006-06-18 | Preparation with blood-pressure, blood-sugar and blood-fat lowering functions and its making method |
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| CN1939506A CN1939506A (en) | 2007-04-04 |
| CN1939506B true CN1939506B (en) | 2010-12-08 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104277958A (en) * | 2014-10-30 | 2015-01-14 | 范鹏琳 | Health wine for reducing blood sugar level |
| CN104524138A (en) * | 2014-12-19 | 2015-04-22 | 刘鹏捷 | Traditional Chinese medicine composition for treating hypertension |
| CN104720044B (en) * | 2015-04-13 | 2017-04-26 | 高德龙 | Eye-healthcare pear juice |
| CN105250494A (en) * | 2015-10-30 | 2016-01-20 | 华北理工大学 | Traditional Chinese medicine recipe for improving glycometabolism and preparation process |
| CN105876550A (en) * | 2016-05-13 | 2016-08-24 | 何家英 | Solid drink for diabetic patients |
| CN112057549A (en) * | 2020-04-04 | 2020-12-11 | 杨京润 | Preparation for reducing blood sugar, blood fat and virus and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1437959A (en) * | 2002-02-10 | 2003-08-27 | 杨志东 | Chinese prepartory for treating cardiovascular and cerebrovascular disease and preparation method |
| CN101129817A (en) * | 2007-09-26 | 2008-02-27 | 王福春 | Chinese medicine formulation for treating hypertension and method of producing the same |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1437959A (en) * | 2002-02-10 | 2003-08-27 | 杨志东 | Chinese prepartory for treating cardiovascular and cerebrovascular disease and preparation method |
| CN101129817A (en) * | 2007-09-26 | 2008-02-27 | 王福春 | Chinese medicine formulation for treating hypertension and method of producing the same |
Non-Patent Citations (2)
| Title |
|---|
| 巩向军.糖尿病中医药治疗进展.《中国民间疗法》.1998,(第1期),第63-65页. * |
| 田同儒等.脂肪肝及其中医药研究进展.《陕西中医》.2002,第23卷(第7期),第665-668页. * |
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Assignee: Shanxi port life pharmaceutical research & Development Co Ltd Assignor: Yang Jixing Contract record no.: 2011990000709 Denomination of invention: Preparation with blood-pressure, blood-sugar and blood-fat lowering functions and its making method Granted publication date: 20101208 License type: Common License Open date: 20070404 Record date: 20110725 |
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