CN103479744B - Traditional Chinese medicine composition with functions of soothing liver and maintaining beauty - Google Patents
Traditional Chinese medicine composition with functions of soothing liver and maintaining beauty Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition with functions of soothing the liver and maintaining beauty, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is a medicament, a health product or food prepared by raw materials of Chinese thorowax flowers, flos rosae rugosae, plum blossoms, Chinese angelica, roots of rehmannia, szechuan lovage rhizome, white paeony roots and lemons. Clinically, the traditional Chinese medicine composition with the functions of soothing the liver and maintaining beauty can be used for relieving moods, resolving depression, eliminating stagnation, promoting blood circulation for regulating menstruation and regulating internal secretion; and further, with long-term use of the traditional Chinese medicine composition, breast glands lobular hyperplasia, freckle, chloasma and pimples which are caused by qi-blood disharmony, liver-qi depression and endocrine dyscrasia of women can be prevented and cured, metabolism is promoted, organism immunity is improved, and pachulosis and decrepitude of skins can be relived.
Description
Technical field
The present invention is specifically related to a kind of soothing the liver skin care Chinese medicine composition, belongs to food, health product or the field of Chinese medicines.
Background technology
It is origin of hundreds of diseases that tcm theory thinks qi-blood disharmony.The life of people take QI and blood as this, and the disease of people injures QI and blood invariably.Gas and blood are the two large material bases forming human body and maintain human life activity, and gas is the cereal nutrient in human body, and blood is foodstuff essence China, and QI and blood mediation the five internal organs, spill old six internal organs, maintain normally carrying out of vital movement.QI-blood circulation is normal, then the various physiological activity of human body just can normally play, and QI-blood circulation is not normal, then the physiological activity of human normal just can not normally run, and human body will be in morbid state.Relation between gas and blood is very close, mutual promotion on physiology, interdepends, mutual profound influence on pathology, therefore has saying of " blood can carry QI, qi promoting blood production, the capable then blood of gas, the stagnation of QI is blood stasis then for qi being the governor of blood, blood being the material foundation of QI ".Therefore, normally whether QI-blood circulation, is the key with or without disease.QI-blood circulation is normal, and human body cell normally can carry out energy exchange, and cell function is normal, and cell can play its due function.QI-blood circulation is abnormal, and the normal energy exchange processes of cell is by suppression to a certain extent, and cell function can not normally play, and human body is in morbid state.Whether QI-blood circulation is normally related to the whether normal of cellular energy exchange.
Gas, blood are the base substances forming human life, physiological activity, and women take QI and blood as this, no matter physiological and pathological, all close with qi-blood relationship, therefore gas, the taking good care of particular importance women of blood.Qi-blood disharmony, All kinds of diseases and ailments break out, QI and blood fill and, all kinds of diseases and ailments not life.And modern female, stress is large, diet is irregular and shortage motion, the physiological characteristics of women in addition, during menstruation, blood has a certain amount of consumption and loss, menstrual period emotion, also can there are some changes in psychology, estrogen secretion in health reduces, and menoxenia is disorderly, mammary gland nodules hypertrophy also just occurs often, the simultaneously adjoint skin that also has changes, as the colour of skin is dim, black eye, whole face small pox, pigmentation, turns pale etc.Therefore women focuses on regulating QI and blood, dispersing the stagnated live-QI to relieve the stagnation of QI, endocrine regulation, improves hormone level, is health and has beautiful appearance originally.
For qi-blood disharmony card, usual employing dispersing the stagnated live-QI to relieve the stagnation of QI, nourshing blood and promoting blood circulation, regulating menstruation are regulated the flow of vital energy, the method for endocrine regulation, make that QI and blood is full, skin-protecting face nursing, health microcirculation recovers normal, Endocrine Levels is in poised state, just can not produce alluvial toxin in such body, various gynaecopathia just can be readily solved.
Therefore, providing a kind of has soothing the liver skin care Chinese medicine preparation that is positive and sure effect to be a problem being worth research.
Radix Bupleuri is large conventional Chinese medicine, and Radix Bupleuri, decoction pieces, extract and formulation products are national strategy new industry and product, industry chain length, and economic scale is large, and development space is large, is the comprehensive large industry of influence area economic development.States Pharmacopoeia specifications Radix Bupleuri only has root just can be used as medicine, so the general root with Radix Bupleuri is used as medicine at present, root containing saponin, has the effects such as antipyretic, analgesia, calmness, antiinflammatory.But Radix Bupleuri is also containing other parts such as stem, leaf and flowers except root, and Radix Bupleuri flower is the pistil of Radix Bupleuri, Radix Bupleuri dis-medicinal part, according to determination and analysis, Radix Bupleuri flower is not containing saponin, generally believe that Radix Bupleuri all herbal medicine can reduce the quality of medicine, therefore Radix Bupleuri is spent and is generally gone out of use.In recent years, people carry out analysis and research to Radix Bupleuri flower and find Radix Bupleuri containing plurality of active ingredients in spending, such as: Quercetin, ergosterol etc.; Quercetin has inhibitory action to human ovarian cancer's cell, and ergosterol has material impact to Ca,P metabolism and children's's bone growth.Radix Bupleuri perianth is discarded, and not only causes the huge wasting of resources, also causes economic loss to peasant, is unfavorable for very much the development of Radix Bupleuri industry.
But for the application of Radix Bupleuri flower in concrete medicine, also nobody relates to.And have no both at home and abroad at present with Radix Bupleuri flower as raw material makes food, health product, the bibliographical information of medicine and patent application.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, improve Radix Bupleuri industry now and Radix Bupleuri is spent to the situation of zero utilization, make up the blank of Radix Bupleuri flower in medicinal application simultaneously, there is provided Radix Bupleuri flower preparing the application that has in the Chinese medicine composition of soothing the liver face-nursing function, provide further a kind of to have actively for one of main component with Radix Bupleuri flower and the conditioning women of sure effect is qi-blood disharmony, depression of liver-QI, endocrine disturbance Chinese medicine composition.
In order to realize foregoing invention object, the technical solution used in the present invention is as follows:
A kind of soothing the liver skin care Chinese medicine composition, it is medicament, health product or the food made for primary raw material with Radix Bupleuri flower.
Further, Radix Bupleuri is spent and can be used with one or more drug matchings of QI and blood regulating, as: Flos Rosae Rugosae, Flos Mume, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Fructus Citri Limoniae, Cortex Moutan, Fructus Gardeniae, Flos Carthami, Radix Rehmanniae Preparata, Fructus Citri Sarcodactylis, Fructus Corni, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, the Radix Astragali, Radix Codonopsis, Radix Et Rhizoma Rhei, Ramulus Cinnamomi, Fructus Rubi, Colla Corii Asini, Herba Herminii, Cortex Albiziae, Caulis Polygoni Multiflori, Placenta Hominis, Radix Panacis Quinquefolii, Herba Leonuri, Chen Ai, Flos Chrysanthemi, Fructus Lycii etc.
Soothing the liver skin care Chinese medicine composition provided by the invention, it is medicament, health product or the food made for raw material with Radix Bupleuri flower, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, the Radix Paeoniae Alba.With Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, the Radix Paeoniae Alba same used time, in Chinese medicine composition, the weight portion of each raw material is preferably: Radix Bupleuri flower 10-50 part, Radix Angelicae Sinensis 2-12 part, Radix Rehmanniae 2-12 part, Rhizoma Chuanxiong 2-12 part, Radix Paeoniae Alba 5-16 part.
Best, soothing the liver skin care Chinese medicine composition of the present invention, raw material also comprises Flos Rosae Rugosae, Flos Mume and Fructus Citri Limoniae.This Chinese medicine composition altogether for monarch drug, with Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, the Radix Paeoniae Alba altogether for ministerial drug, enters liver for adjuvant drug with Fructus Citri Limoniae priming with Radix Bupleuri flower, Flos Rosae Rugosae, Flos Mume.Soothing the liver relieving restlessness resolving depression spent by Radix Bupleuri, Flos Rosae Rugosae circulation of qi promoting and blood resolving depression, Flos Mume dispersing the stagnated liver-QI for regulating the stomach dissipating depression of QI; Radix Angelicae Sinensis nourishing the liver is invigorated blood circulation, and the Radix Rehmanniae enters kidney YIN nourishing, and Rhizoma Chuanxiong enters blood system and unclogs and readjusts gas in blood, and Radix Paeoniae Alba easing the affected liver nourishes blood; Fructus Citri Limoniae has another name called Herba Leonuri fruit, sour, sweet, put down, promote the production of body fluid, spleen invigorating, circulation of qi promoting.All medicines share, and have significant dispersing the stagnated live-QI to relieve the stagnation of QI, promoting blood flow to regulate menstruation, skin-protecting face nursing effect.
Further, in soothing the liver skin care Chinese medicine composition of the present invention, the weight portion of each raw material is: Radix Bupleuri flower 10-50 part, Flos Rosae Rugosae 10-35 part, Flos Mume 5-20 part, Radix Angelicae Sinensis 2-12 part, Radix Rehmanniae 2-12 part, Rhizoma Chuanxiong 2-12 part, Radix Paeoniae Alba 5-16 part, Fructus Citri Limoniae 2-10 part.
Preferably, in soothing the liver skin care Chinese medicine composition of the present invention, the weight portion of each raw material is: Radix Bupleuri flower 12-30 part, Flos Rosae Rugosae 12-25 part, Flos Mume 6-17 part, Radix Angelicae Sinensis 5-10 part, Radix Rehmanniae 5-10 part, Rhizoma Chuanxiong 5-10 part, Radix Paeoniae Alba 8-15 part, Fructus Citri Limoniae 3-8 part.
Preferred, in soothing the liver skin care Chinese medicine composition of the present invention, the weight portion of each raw material is: Radix Bupleuri flower 18-25 part, Flos Rosae Rugosae 13-20 part, Flos Mume 8-16 part, Radix Angelicae Sinensis 7-9 part, Radix Rehmanniae 7-9 part, Rhizoma Chuanxiong 7-9 part, Radix Paeoniae Alba 10-14 part, Fructus Citri Limoniae 4-7 part.
Most preferably, in soothing the liver skin care Chinese medicine composition of the present invention, the weight portion of each raw material is: Radix Bupleuri spends 20 parts, Flos Rosae Rugosae 15 parts, 10 parts, Flos Mume, Radix Angelicae Sinensis 8 parts, 8 parts, the Radix Rehmanniae, Rhizoma Chuanxiong 8 parts, the Radix Paeoniae Alba 12 parts, 5 parts, Fructus Citri Limoniae.
Radix Bupleuri flower is preparing the application had in the Chinese medicine composition of soothing the liver face-nursing function.
The medicament of soothing the liver skin care Chinese medicine composition of the present invention, health product or food, can be processed through extraction or other modes by the raw material that above-mentioned formula is formed, make pharmaceutically active substance, with this pharmaceutically active substance for raw material, add medicine, health product or food acceptable carrier or adjuvant when needing, conveniently technology is made.Described active substance can obtain by extracting raw material respectively, also can be obtained by the common raw material that extracts, also can obtain by other means, as: by pulverizing, squeezing, grind, sieve, extract, distill, the method such as water extraction, alcohol extraction, ester carry, chromatography obtains, these active substances can be the materials of the clathrate form of volatile oil, can be the material of extractum form, can be dry extract also can be fluid extract, needs to determine to make different concentration according to the difference of preparation.
Soothing the liver skin care Chinese medicine compositions of the present invention, its pharmaceutically active substance is through processing and extracts obtained, and processing can adopt any combination in said method.
A kind of preparation method of soothing the liver skin care Chinese medicine composition of the present invention, comprises the following steps:
(1) Radix Bupleuri flower is taken in proportion, Flos Rosae Rugosae, Flos Mume, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Fructus Citri Limoniae;
(2) raw material in step (1) is prepared into extract or crude drug powder in the following manner:
A) extract or crude drug powder is prepared into respectively,
B) one or more mixed raw materials standby one-tenth extract or crude drug powder,
C) whole mixed raw material standby one-tenth extract or crude drug powder;
(3) by the extract of gained raw material in step (2) or the mixing of crude drug powder, acceptable various pharmaceutical dosage form, health product or food is made.
Further, in the preparation method of soothing the liver skin care Chinese medicine composition of the present invention, step (2) comprising:
(2) get the Radix Bupleuri flower in step (1), Flos Rosae Rugosae, Flos Mume, mixing, extracts its volatile oil, and volatile oil is made clathrate, get the Radix Angelicae Sinensis in step (1), the Radix Rehmanniae, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Fructus Citri Limoniae, mixing, extracts, obtains extract;
Soothing the liver skin care Chinese medicine composition of the present invention conveniently technique adds customary adjuvant or carrier can make one or more products such as decoction, medicinal tea, beverage, oral liquid, mixture, granule, capsule, tablet, syrup, buccal tablet, chewable tablet, electuary, pill, drop pill or injection.Such as, take Radix Bupleuri flower in proportion, Flos Rosae Rugosae, Flos Mume, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Fructus Citri Limoniae, pulverized by above-mentioned raw materials, mix homogeneously, every part of health paper bag of making tea by a certain amount of loading, after sealing, packaging, namely makes medicinal tea; Or Radix Bupleuri flower, Flos Rosae Rugosae, Flos Mume is mixed in proportion, and adopts extraction by steam distillation volatile oil, add carrier, make clathrate, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Fructus Citri Limoniae is mixed in proportion, and uses decocting cooking method to extract thick paste, drying under reduced pressure, pulverizes, obtains dry extract, mix with above-mentioned clathrate, add adjuvant, mix homogeneously, granulate, encapsulated, obtain capsule.
Compared with prior art, the invention has the beneficial effects as follows:
Soothing the liver skin care Chinese medicine composition of the present invention, provide a kind of with the colored Chinese medicine composition for one of main constituent of Radix Bupleuri first, achieve the comprehensive utilization of Radix Bupleuri, compensate for the blank of Radix Bupleuri flower in medicinal application, compositions dispersing the stagnated live-QI to relieve the stagnation of QI of the present invention, promoting blood flow to regulate menstruation, skin-protecting face nursing Be very effective, side effect is little, and life-time service can soothing the liver relieving restlessness, prevent and treat the cyclomastopathy that endocrine regulation causes, freckle, chloasma, skin sore, acne; Enhance metabolism, improve body immunity, improve pachylosis aging etc.And show through clinical observation, its total effective rate reaches 91.76%.
Chinese medicine composition of the present invention both can make health product, food, can make medicine again, had greatly expanded the scope of application.Medicine material of the present invention all easily obtains from the market, and preparation method is simple, has very strong application value.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
Following embodiment and experimental technique, if no special instructions, be conventional method; Described reagent and medicine, if no special instructions, all can obtain from commercial channels.
Embodiment 1 medicinal tea
Radix Bupleuri flower 10g, Flos Rosae Rugosae 13g, Flos Mume 10g, Radix Angelicae Sinensis 5g, Radix Rehmanniae 5g, Rhizoma Chuanxiong 5 g, the Radix Paeoniae Alba 8 g, Fructus Citri Limoniae 2g, pulverized by above-mentioned raw materials, mix homogeneously, every part of 5g loads the health paper bag of making tea, and after sealing, packaging, namely makes medicinal tea.
Embodiment 2 beverage
Radix Bupleuri flower 25g, Flos Rosae Rugosae 20g, Flos Mume 15g mix, and adopt its volatile oil of extraction by steam distillation, add beta-schardinger dextrin-, make clathrate in volatile oil; Radix Angelicae Sinensis 10g, Radix Rehmanniae 10g, Rhizoma Chuanxiong 10g, Radix Paeoniae Alba 13g, Fructus Citri Limoniae 8g, mix homogeneously, decocting cooking method extracts thick paste, drying under reduced pressure, pulverizes, obtains dry extract, mix with clathrate, by following common process program, namely comprise the steps such as allotment-homogenizing-degassed-pasteurize-fill-cooling, can finished beverage be obtained.
Embodiment 3 capsule
Radix Bupleuri flower 30g, Flos Rosae Rugosae 25g, Flos Mume 20g mix, and adopt its volatile oil of extraction by steam distillation, add beta-schardinger dextrin-, make clathrate in volatile oil; Radix Angelicae Sinensis 10g, Radix Rehmanniae 10g, Rhizoma Chuanxiong 10g, Radix Paeoniae Alba 15g, Fructus Citri Limoniae 8g, mix homogeneously, decocting cooking method extracts thick paste, drying under reduced pressure, pulverizes, obtains dry extract, mix with clathrate, add Pulvis Talci, starch, mix homogeneously, conveniently technique is granulated, encapsulated, obtains capsule.
Embodiment 4 tablet
Radix Bupleuri flower 40g, Flos Rosae Rugosae 15g, Flos Mume 10g mix, and adopt its volatile oil of extraction by steam distillation, add beta-schardinger dextrin-, make clathrate in volatile oil; Radix Angelicae Sinensis 5g, Radix Rehmanniae 5g, Rhizoma Chuanxiong 5g, Radix Paeoniae Alba 8g, Fructus Citri Limoniae 2g, mix homogeneously, decocting cooking method extracts thick paste, drying under reduced pressure, pulverizes, obtains dry extract, mix with clathrate, add calcium carbonate, starch, mix homogeneously, tabletting, obtain tablet.
Embodiment 5 oral liquid
Radix Bupleuri flower 45g, Flos Rosae Rugosae 30g, Flos Mume 20g mix, and adopt its volatile oil of extraction by steam distillation, add beta-schardinger dextrin-, make clathrate in volatile oil; Radix Angelicae Sinensis 10g, Radix Rehmanniae 10g, Rhizoma Chuanxiong 10g, Radix Paeoniae Alba 15g, Fructus Citri Limoniae 8g, mix homogeneously, decocting cooking method extracts thick paste, drying under reduced pressure, pulverizes, obtains dry extract, mix with clathrate, add water and make dissolving, adjust ph, add solubilizing agent, antiseptic, correctives, fill, make oral liquid.
Embodiment 6 granule
Radix Bupleuri flower 50g, Flos Rosae Rugosae 35g, Flos Mume 20g mix, and adopt its volatile oil of extraction by steam distillation, add beta-schardinger dextrin-, make clathrate in volatile oil; Radix Angelicae Sinensis 10g, Radix Rehmanniae 10g, Rhizoma Chuanxiong 10g, Radix Paeoniae Alba 15g, Fructus Citri Limoniae 8g, mix homogeneously, decocting cooking method extracts thick paste, drying under reduced pressure, pulverizes, obtains dry extract, mix with clathrate, add dextrin, cane sugar powder, mixing, add appropriate 90% ethanol, conveniently technique makes granule.
Embodiment 7 decoction
Radix Angelicae Sinensis 5g, Radix Rehmanniae 5g, Rhizoma Chuanxiong 5g, Radix Paeoniae Alba 8g, Fructus Citri Limoniae 2g, container is put in mixing, add suitable quantity of water, decoct to water boiling, after 3-5 minute, add Radix Bupleuri flower 20g, Flos Rosae Rugosae 15g, Flos Mume 10g, again decoct 5-10 minute, total decocting time is about 10-20 minute, removes solid residue, can obtain decoction of the present invention.
Experimental example 1
One, generally case is applied
1. case selection standard
1.1 tcm syndrome differentiation and typing standards: qi-blood disharmony, liver qi stagnation type.Disease opinion feels depressed, irritable emotion, lassitude, irritable, does not uncomfortable in chestly relax, belch is sighed, menoxenia (preceeded menorrhea or later stage), and mammary gland nodules or distending pain of the breast, sleep poor, lustreless complexion, pigmentation or length have skin sore or length to have acne, white and thin fur or BOHUANG, stringy and hesitant pulse.
1.2 inclusive criterias: be qi-blood disharmony according to tcm diagnosis standard diagnostics, the melancholia patient of depression of liver-QI, modern medical diagnosis is melancholia or autonomic nervous dysfunction.The range of age is in the women in 21-54 year; Treat in first 30 days and do not use the Chinese medicine relevant to primary disease or Western medicine, therapist can be adhered to the course for the treatment of according to plan.
1.3 exclusion standards: do not meet above-mentioned traditional Chinese medical science melancholia disharmony between QI and blood, the depression of liver-QI symptom person of description, the age is less than 20 years old or is greater than 55 years old person; Gestation or women breast-feeding their children, have the whole body major disease persons such as diabetes, heart disease, infectious disease; There is Chronic consumptions as causers such as tuberculosis, tumor, chronic hepatopathy, nephropathy.
1.4 reject standard: do not complete person's course for the treatment of, the terminator because of serious adverse reaction.
21. clinical observations
In certain traditional Chinese medical science Grade A hospital in October, 2007 to 2012 year JIUYUE consulting patients in out-patient department, choose the patient that 540 examples meet above inclusive criteria, random point four groups, treatment group 170 example, age 25-50 year, year mean age (37.6 ± 2.5), course of disease 2-10, wherein, 16 routine patients are occurred together dysmenorrhea, 10 routine patients suffer from hysteromyoma, and occur together migraineur 8 example, and the above-mentioned disease assorted patient that holds concurrently has 22 examples.
Matched group 1 example, age 21-52 year, the mean age (38.2 ± 2.1) year, course of disease 1-12, wherein, 11 routine patients are occurred together dysmenorrhea, and 6 routine patients suffer from hysteromyoma, and occur together migraineur 2 example, and the above-mentioned disease assorted patient that holds concurrently has 19 examples.
Matched group 2 170 example, age 23-54 year, the mean age (38.5 ± 2.2) year, course of disease 2-11, wherein, 13 routine patients are occurred together dysmenorrhea, and 9 routine patients suffer from hysteromyoma, and occur together migraineur 5 example, and the above-mentioned disease assorted patient that holds concurrently has 18 examples.
Matched group 3 30 example, age 25-50 year, the mean age (37.6 ± 2.5) year, course of disease 2-10, wherein, 3 routine patients are occurred together dysmenorrhea, and 1 routine patient is with hysteromyoma, and occur together migraineur 2 example, and the above-mentioned disease assorted patient that holds concurrently has 5 examples.
Four groups in age, the course of disease, severity extent, extent of disease, symptom etc. without marked difference (P > 0.05), there is comparability.
3. Therapeutic Method
Treatment group: select decoction of the present invention (according to the preparation of embodiment 7 method) to take, 1 dose/day, sooner or later respectively once, after taking first quarter moon, uses medicinal tea of the present invention instead and continues to take three months, each 5g, and every day, boiled water was taken after being infused in hot water or decoction three guarantees.Treatments period is stopped using other medicines, and suitable treated by psychotherapy, advise patient's daily life rule, do not stay up late, diet is preference not, eats the vegetable and fruit of being rich in vitamin more.
Matched group one: paroxetine adds compound dimension B and takes orally, and paroxetine 30mg, takes once, be adjusted to 20mg after first quarter moon every morning, continues to take three months; Period adds compound dimension B simultaneously, each 2, every day three times.Treatments period is stopped using other medicines, and suitable treated by psychotherapy, advise patient's daily life rule, do not stay up late, diet is preference not, eats the vegetable and fruit of being rich in vitamin more.
Matched group two: do not use any medicine, suitable treated by psychotherapy, advise patient's daily life rule, do not stay up late, diet is preference not, eats the vegetable and fruit of being rich in vitamin more.
Matched group three: use the decoction oral that boils of compositions lacking Radix Bupleuri flower, 1 dose/day, sooner or later each once, after taking first quarter moon, the medicinal tea that the compositions that continuations is spent without Radix Bupleuri is made is made tea and is taken three months, each 5g, and every day, boiled water was taken after being infused in hot water or decoction three guarantees.Treatments period is stopped using other medicines, and suitable treated by psychotherapy, advise patient's daily life rule, do not stay up late, diet is preference not, eats the vegetable and fruit of being rich in vitamin more.
4. efficacy assessment standard
Recovery from illness: clinical symptoms, sign disappear; Effective: clinical symptoms, sign disappear substantially; Take a turn for the better: clinical symptoms, sign alleviate to some extent; Invalid: clinical symptoms, sign are without alleviating or adding severe one.Total effective rate=(recovery from illness+effective)/total number of cases * 100%.
5. statistical method
Enumeration data represents with percentage rate (%), compares and adopt X between group
2(X square) inspection, P < 0.05 has statistical significance for difference.Concrete numerical value and the results are shown in Table 1.
Table 1 four groups of Clinical efficacy comparisons
Note: treatment group compares with matched group one, matched group two and matched group three, P < 0.05
6. result
As seen from the results in Table 1, treatment group total effective rate is 91.76%, higher than the total effective rate 78.23% of matched group one, the total effective rate 20.58% of matched group two and the total effective rate 60.00% of matched group three, difference has statistical significance (P < 0.05), prove to use Chinese medicine composition of the present invention, dispersing the stagnated live-QI to relieve the stagnation of QI, promoting blood flow to regulate menstruation, skin-protecting face nursing Be very effective, treatment group curative effect is obviously better than three matched groups, the effect of the visible use present composition is better than the effect using Western medicine, also show that Radix Bupleuri flower has irreplaceable in the compositions of the present invention, important effect, Radix Bupleuri flower has obvious synergistic function with all the other components in the present composition.Four groups all there is not obvious adverse reaction.
Two, typical apply case
Case 1: Zhao so-and-so, female, 31 years old, married fertility.Preceeded menorrhea, more or less mensis in amount, color is scarlet or purplish red, accompanies stasis of blood block, breast, the breast side of body and lower abdominal distention pain, irritable, long little acne many on face, pulse condition stringy and rapid pulse.
Therapeutic Method: dispersing the stagnated live-QI to relieve the stagnation of QI, promoting blood flow to regulate menstruation, skin-protecting face nursing.
Use Chinese medicine composition decoction of the present invention (according to the preparation of embodiment 7 method), every day, potion, took five doses continuously, and above-mentioned symptom and sign disappear and fully recover.
Case 2: Lee so-and-so, female, 46 years old, depressed, delayed menstrual cycle, amount is few, and color normally presss from both sides a small amount of stasis of blood block, does not uncomfortable in chestly relax, and belch slightly subtracts, mammary gland nodules, lower abdominal distention pain, and complexion dimness is long has chloasma, pachylosis, and tongue fur BOHUANG, deep and stringy pulse is unable.
Therapeutic Method: dispersing the stagnated live-QI to relieve the stagnation of QI, promoting blood flow to regulate menstruation, skin-protecting face nursing.
By taking medicinal tea of the present invention (according to the preparation of embodiment 1 method), each one bag, every day three times, drinking after boiled water bubble, serveing on and disappearing by 3 months above-mentioned symptoms and sign.
Case 3: Zhang, female is 20 years old, unmarried.Face is skin sore acne repeatedly, emotion irritability, discomfort uncomfortable in chest, menstrual period first or after, blockage of menstruation, breast is done swollen, the breast side of body and lower abdominal distention pain, thin fur stringy pulse.
Therapeutic Method: dispersing the stagnated live-QI to relieve the stagnation of QI, promoting blood flow to regulate menstruation, skin-protecting face nursing.
By taking tablet of the present invention (according to the preparation of embodiment 4 method), each menstruation starts to take before coming, and each a slice, every day 3 times, takes 7 days continuously.Take above-mentioned symptom after 6 months continuously all to disappear, not further consultation again in 3 years.
Above model case proves Chinese medicine composition of the present invention, has significant dispersing the stagnated live-QI to relieve the stagnation of QI, promoting blood flow to regulate menstruation, skin-protecting face nursing effect, side effect is little, and life-time service can soothing the liver relieving restlessness, prevent and treat the cyclomastopathy that endocrine regulation causes, freckle, chloasma, skin sore, acne; Enhance metabolism, improve body immunity, improve pachylosis aging etc.
Claims (7)
1. a soothing the liver skin care Chinese medicine composition, it is characterized in that, described Chinese medicine composition is medicament, health product or the food be made up of following raw material: Radix Bupleuri flower 10-50 part, Flos Rosae Rugosae 10-35 part, Flos Mume 5-20 part, Radix Angelicae Sinensis 2-12 part, Radix Rehmanniae 2-12 part, Rhizoma Chuanxiong 2-12 part, Radix Paeoniae Alba 5-16 part, Fructus Citri Limoniae 2-10 part.
2. according to the soothing the liver skin care Chinese medicine composition described in claim 1, it is characterized in that, in Chinese medicine composition, the weight portion of each raw material is: Radix Bupleuri flower 12-30 part, Flos Rosae Rugosae 12-25 part, Flos Mume 6-17 part, Radix Angelicae Sinensis 5-10 part, Radix Rehmanniae 5-10 part, Rhizoma Chuanxiong 5-10 part, Radix Paeoniae Alba 8-15 part, Fructus Citri Limoniae 3-8 part.
3. according to the soothing the liver skin care Chinese medicine composition described in claim 2, it is characterized in that, Radix Bupleuri flower 18-25 part, Flos Rosae Rugosae 13-20 part, Flos Mume 8-16 part, Radix Angelicae Sinensis 7-9 part, Radix Rehmanniae 7-9 part, Rhizoma Chuanxiong 7-9 part, Radix Paeoniae Alba 10-14 part, Fructus Citri Limoniae 4-7 part.
4. according to the soothing the liver skin care Chinese medicine composition described in claim 3, it is characterized in that, in Chinese medicine composition, the weight portion of each raw material is: Radix Bupleuri spends 20 parts, Flos Rosae Rugosae 15 parts, 10 parts, Flos Mume, Radix Angelicae Sinensis 8 parts, 8 parts, the Radix Rehmanniae, Rhizoma Chuanxiong 8 parts, the Radix Paeoniae Alba 12 parts, 5 parts, Fructus Citri Limoniae.
5. the soothing the liver skin care Chinese medicine composition according to any one of claim 1-4, is characterized in that: described medicament, health product or food are: decoction, medicinal tea, beverage, oral liquid, mixture, granule, capsule, tablet, pill or drop pill.
6. a kind of preparation method of the soothing the liver skin care Chinese medicine composition according to any one of claim 1-4, comprises the following steps:
(1) Radix Bupleuri flower is taken in proportion, Flos Rosae Rugosae, Flos Mume, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Fructus Citri Limoniae;
(2) raw material in step (1) is prepared into extract or crude drug powder in the following manner:
A) extract or crude drug powder is prepared into respectively,
B) one or more mixed raw materials standby one-tenth extract or crude drug powder;
(3) by the extract of gained raw material in step (2) or the mixing of crude drug powder, acceptable various pharmaceutical dosage form, health product or food is made.
7. as described in claim 1-4 any one, Chinese medicine composition is preparing the application had in the medicine of soothing the liver face-nursing function.
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| CN102178631A (en) * | 2011-05-04 | 2011-09-14 | 北京华夏美枫化妆品技术中心 | Skin care combination with effect of dispelling wrinkles, preparation and preparation method |
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| 北柴胡花化学成分研究;张丽等;《中药材》;20100731;第33卷(第7期);第1086-1088页 * |
| 槲皮素及异槲皮素、芦丁抗自由基活性的比较研究;金越等;《中草药》;20070331;第38卷(第3期);第408-412页 * |
| 槲皮素对肝脏的药理作用研究进展;辛秀等;《中国中医药信息杂志》;20080531;第15卷;第102-104页 * |
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