CN103463151A - Method for producing pure mountain ginseng lozenge - Google Patents
Method for producing pure mountain ginseng lozenge Download PDFInfo
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- CN103463151A CN103463151A CN2013103544239A CN201310354423A CN103463151A CN 103463151 A CN103463151 A CN 103463151A CN 2013103544239 A CN2013103544239 A CN 2013103544239A CN 201310354423 A CN201310354423 A CN 201310354423A CN 103463151 A CN103463151 A CN 103463151A
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Abstract
The invention provides a method for producing pure mountain ginseng lozenge, and relates to an improvement of health product, and the producing method comprises the following steps: 1. drying and crushing mountain ginseng, sieving mountain ginseng powder with a 80-800 mesh sieve, and mixing mountain ginseng powder and distilled water according to feed liquid weight ratio 1:20, extracting for three times, each of which lasts for 18 min or more, filtering, merging filtrates, and drying residue; 2. condensing the filtrate below 60 DEG C till the relative density of the extract is 1.10-1.15; 3. mixing the dried residue and the extract, adding distilled water and diluting till the relative density is 1.3-1.4, preparing the mixed mountain ginseng extract and the residue into wet particles, and drying at 68-75 DEG C; 4. compacting the wet particles into tablets by rotary type tablet press. The invention has the advantages that the oral mucosa and the oral gastrointestinal tract absorption pathway are combined, thereby the active ingredients in the mountain ginseng powder can be rapidly absorbed by human body, and the original flavour of the mountain ginseng is maintained, and the health care function is improved, moreover, the dosage is greatly reduced, and the utilization rate of the rare resource is increased.
Description
Technical field
The invention belongs to food technology field, relate to a kind of improvement of health product.
Background technology
Radix Ginseng (
panas Ginsengc. A. Mey.) the main distribution is grown in the Changbaishan area of China northeast, press tcm theory, its main effect for " main tonifying five ZANG-organs, calm the nerves, determine soul, spasmolytic throb with fear, remove pathogen, improving eyesight, happily, Fructus Alpiniae Oxyphyllae." at present; numerous countries have carried out developmental research with the drug effect to Radix Ginseng; up to the present; research shows; the main component of Radix Ginseng comprises ginsenoside, polysaccharide, polypeptide, aminoacid, volatilization wet goods; it has certain antitumor, protects the liver, improves the effects such as immunity of organisms, obesity, anti-diabetic.
At present, Radix Ginseng, as a kind of Chinese medicine, has obtained development and utilization widely, along with Radix Ginseng in recent years progresses into field of food, numerous producers have been developed to Radix Ginseng all multi-products, as Radix Ginseng tea, Radix Ginseng bread, ginseng candies etc., aspect pharmacy, Panax Capsule, Radix Ginseng decoction pieces, Radix Ginseng buccal tablet, people's ginseng dripping pill is corresponding and go out, but these preparations, all added the adjuvants such as a large amount of additives, sweeting agent, starch forming agent, this has not only affected the taste of Radix Ginseng, has also reduced drug effect.
Summary of the invention
The objective of the invention is: a kind of manufacture method of pure SHANSHEN buccal tablet is provided, and it is not adding adjuvant, does not change under SHANSHEN effective ingredient prerequisite, produces in batches and directly eats.
Manufacture method of the present invention is:
1. dried SHANSHEN is pulverized, crossed the 80-800 mesh sieve, SHANSHEN powder, distilled water, by feed liquid weight ratio 1:20 mixing lixiviate three times, more than each 18min, are filtered to merging filtrate, residue drying.
2. filtrate is concentrated under 60 ℃ to the extractum that relative density is 1.10-1.15.
3. dried residue and extractum are mixed, it is 1.3-1.4 that adding distil water is diluted to relative density, and SHANSHEN extractum and residue after mixing are made to wet granular, 68-75 ℃ of drying.
4. select rotary tablet machine, by the wet granular compacting in flakes.
The present invention pulverizes dried SHANSHEN, the preferred 80-500 mesh sieve of crossing.
The invention has the beneficial effects as follows:
1. the present invention utilizes Panax Ginseng to make the SHANSHEN buccal tablet, does not add any auxiliary material in manufacturing process, has increased the effect of SHANSHEN buccal tablet.
2. the present invention is in making the process of buccal tablet, screened the required SHANSHEN of buccal tablet and pulverized order number and lixiviate extraction time, with buccal tablet processing technology in the past, compares, and greatly shortened the production cycle, reduced production cost.
3. the present invention is more convenient as food materials using SHANSHEN, all-ages, easy to carry.
By oral mucosa, in conjunction with oral gastrointestinal absorption approach, the effective ingredient in the SHANSHEN powder is entered rapidly in body, both retained the original flavor of SHANSHEN, more improved health care, and can make dose minimizing at double, the utilization rate of the scarce resource effectively improved.
The specific embodiment
Utilize the phenolsulfuric acid method to measure the dissolution of different meshes and the polysaccharide of decoction pieces SHANSHEN within the different time, detailed process is as follows:
1. the SHANSHEN sample is pulverized in the processing of sample, crosses respectively 80-150 mesh sieve, 350-500 mesh sieve.The 500-800 mesh sieve, respectively get the sample of different meshes sieve in right amount, and by the feed liquid weight ratio, 1:20 adds distilled water, difference lixiviate 10min, 20min, 40min, 60min.After extracting once, extracting solution is dried under 90 ℃, the water standardize solution in the 10ml volumetric flask, 0.45 μ m filtering with microporous membrane, standby.
2. the drafting precision of polysaccharide standard curve takes the glucose sugar of 5.0mg after 105 ℃, joins in the 50ml volumetric flask ultrasonic standardize solution.Obtain the reference substance solution that concentration is 0.1mg/ml, it is 0.01,0.02,0.03 that the word reference substance solution is mixed with respectively concentration, 0.04,0.05 the glucose reference substance solution of 0.06 mg/ml, get respectively this solution of 1ml and join in the 10ml test tube, the phenol solution that adds 1ml 6%, and then adding the 5ml concentrated sulphuric acid, boiling water bath 15min after jolting evenly measures its absorbance after cooling under 490nm.
Its regression equation is: Y=14.751X+0.0085, R
2=0.9985.
In sample the determination of polysaccharide measurement result in Table 1.
Each processes polyoses content (mg/g) in the SHANSHEN sample table 1
Table 1 can be found out, in four kinds of different processing, what in the SHANSHEN section, polysaccharide leached is minimum, along with pulverizing reducing of order number, the stripping quantity of polysaccharide increases gradually, at the 350-500 order, is that dissolution rate reaches maximum, pulverizing the order number is reducing, the dissolution rate of polysaccharide presents the trend of reduction on the contrary, and this is likely too small because pulverize the order number, has destroyed the effective ingredient in the SHANSHEN.At lixiviate 10min, 20min, 40min, 60min is in the time, the SHANSHEN section is along with the increase of extraction time, and the stripping quantity of polysaccharide is corresponding increase also, but its increase trend tends towards stability after 20min, and the 80-150 order, the 350-500 order, the stripping quantity of 500-800 order polysaccharide after 20min does not increase counter subtracting, and considers that the present invention will make SHANSHEN pure SHANSHEN decoction pieces, order number too large (80-150) is unfavorable for the interior absorption to the SHANSHEN composition of human body, and mouthfeel is not good enough.The order number is too little, and in SHANSHEN, effective ingredient has loss, has more increased the pulverizing difficulty, has improved Financial cost, so this experimental selection 350-500 purpose SHANSHEN powder is done the SHANSHEN buccal tablet.
The object of the invention is to utilize HPLC to measure the dissolution of different meshes and the saponin of decoction pieces SHANSHEN within the different time, detailed process is as follows:
1. the processing of sample is identical with " 2 sample treatment under the summary of the invention item ".
The preparation of ginsenoside's reference substance solution respectively precision take ginsenoside's reference substance Rg
1, Re, Rg
2, Rb
1, Rb
2, Rd(Products in China institute provides) and each 5.0mg, be dissolved in the 25ml volumetric flask, standardize solution after dissolve with methanol, 0.45 μ m filtering with microporous membrane, can make concentration is 0.2 mgmL
-1the ginsenoside mix the reference substance storing solution.
2. chromatographic condition and system suitability test chromatographic column: Dalian Yi Lite HypersilODS2(250 mm * 4.6 mm, 5 μ m); Column temperature: 30 ℃; Mobile phase: acetonitrile (C)-0.2% phosphoric acid solution (A), gradient elution (0-24min:18%C-22%C; 24-26min:24%C-26%C; 26-30min:26%C-32%C; 30-50min:32%C-33.5%C; 50-55min:33.5%C-38%C; 55-65min:38%C-40%C) flow velocity: 1.0 mLmin
-1; Detect wavelength: 203 nm; Sample size: 20 μ l.Under above-mentioned chromatographic condition, the ginsenoside's retention time in sample and reference substance is basically identical, and theoretical cam curve all is greater than 3000.
The chromatographic condition the invention provides in the dissolution to utilizing HPLC mensuration different meshes and the saponin of decoction pieces SHANSHEN within the different time has carried out the linear relationship investigation:
Get the ginsenoside and mix reference substance solution, by utilizing HPLC to measure the dissolution chromatographic condition sample introduction of different meshes and the saponin of decoction pieces SHANSHEN within the different time, take sample size as abscissa, difference sample introduction 10,20,40,60ul, take peak area as vertical coordinate, the Criterion curve, its regression equation is respectively:
Rg
1: Y=22572X+244437 R
2=0.9991
Re: Y=20779X+298320 R
2=0.9989
Rg
2: Y=44458X+32597 R
2=0.9979
Rb
1: Y=28875X-2044.3 R
2=0.9983
Rc: Y=32773X+21021 R
2=0.9987
Rd: Y=32331X+28871 R
2=0.9997
Precision, stability, repeatability, average recovery are investigated RSD and all are less than 5%, all the related request of Pass Test.
Average recovery test when the invention discloses 350-500 order ginsenoside and extracting 60min, result is as follows:
Take respectively the 350-500 order samples of Ginseng 0.501g of known content, 0.513g, 0.505g, 0.512 totally five parts, accurately add the mixed table of ginsenoside 0.5ml in each sample, by " 2 sample treatment under the summary of the invention item ", by the chromatographic condition sample introduction in the dissolution that utilizes HPLC mensuration different meshes and the saponin of decoction pieces SHANSHEN within the different time, sample size is 20ul, records peak area, and the average recovery rate that extracts the 60min sample is respectively 98.2%(Rg
1), 99.7% (Re), 102.6% (Rg
2), 100.5% (Rb
1),
96.4% (Rc), 97.6% (Rd), RSD is respectively 2.1%, 3.5%, and 2.6%, 1.6%, 2.9%, 3.2%.
The SHANSHEN saponin content result of SHANSHEN under different extraction times that the invention discloses section and different meshes is as follows: in Table 2.
The SHANSHEN sample determination result of table 2. different meshes different extraction times, unit (mg/g)
| Section | 80-150 | 350-500 | 500-800 | ||
| 10min | |||||
| Rg1 | 1.022 | 3.286 | 3.208 | 2.627 | |
| Re | 0.247 | 2.466 | 2.520 | 1.920 | |
| Rg2 | 0.237 | 0.143 | 0.144 | 0.090 | |
| Rb1 | 0.228 | 5.120 | 5.038 | 4.064 | |
| Rc | 0.121 | 3.020 | 2.641 | 2.154 | |
| Rd | 0.010 | 0.871 | 0.758 | 0.527 | |
| 20min | |||||
| Rg1 | 1.585 | 3.341 | 3.453 | 2.415 | |
| Re | 0.386 | 2.444 | 2.312 | 1.760 | |
| Rg2 | 0.033 | 0.160 | 0.113 | 0.086 | |
| Rb1 | 0.377 | 5.473 | 5.603 | 3.824 | |
| Rc | 0.147 | 3.019 | 2.976 | 2.049 | |
| Rd | 0.023 | 0.868 | 0.6986 | 0.494 | |
| 40min | |||||
| Rg1 | 2.190 | 3.213 | 2.959 | 3.335 | |
| Re | 0.531 | 2.382 | 2.542 | 2.420 | |
| Rg2 | 0.041 | 0.132 | 0.192 | 0.116 | |
| Rb1 | 0.459 | 5.573 | 4.741 | 5.274 | |
| Rc | 0.129 | 3.028 | 2.863 | 2.861 | |
| Rd | 0.019 | 0.847 | 0.743 | 0.675 | |
| 60min | |||||
| Rg1 | 2.575 | 3.184 | 3.249 | 3.125 | |
| Re | 0.676 | 2.357 | 2.447 | 2.263 | |
| Rg2 | 0.041 | 0.155 | 0.179 | 0.083 | |
| Rb1 | 0.692 | 5.472 | 4.886 | 4.860 | |
| Rc | 0.229 | 2.980 | 2.653 | 2.585 | |
| Rd | 0.034 | 0.749 | 0.916 | 0.627 |
Table 2 can be found out, increase along with extraction time, ginsenoside's dissolution rate increases gradually, the extraction ratio of Radix Ginseng order number when 80-150 order and 350-500 order is almost identical, but the order number is when 500-800, and extraction ratio reduces on the contrary, this just illustrates when making the SHANSHEN buccal tablet, can not require simply to reduce the order number, thereby increase the dissolubility of effective ingredient in human body in Radix Ginseng.Yet the order number is too large, be unfavorable for the interior absorption to the SHANSHEN composition of human body, and mouthfeel is not good enough.Therefore the present invention selects to make the SHANSHEN buccal tablet with the 350-500 order.
Embodiment 1
1. dried SHANSHEN 2kg is pulverized, cross the 80-150 mesh sieve, by SHANSHEN powder, distilled water, respectively by feed liquid weight ratio 1:20 mixing lixiviate three times, each 25min, filter merging filtrate, residue drying.
2. filtrate is concentrated under 60 ℃ to the extractum that relative density is 1.12.
3. dried residue and extractum are mixed, it is 1.35 that adding distil water is diluted to relative density, and SHANSHEN extractum and residue after mixing are made to wet granular, 70 ℃ of dryings.
4. tabletting is selected rotary tablet machine, and in flakes, specification is the 0.35g*9 sheet, every box 3 plates in compacting.
5. adopt Aluminium-coating Packer to carry out inner packing, with complex pocket and carton, carrying out outer package.
Embodiment 2
1. dried SHANSHEN 2kg is pulverized, cross the 350-500 mesh sieve, by SHANSHEN powder, distilled water, respectively by feed liquid weight ratio 1:20 mixing lixiviate three times, each 20min, filter merging filtrate, residue drying.
2. filtrate is concentrated under 60 ℃ to the extractum that relative density is 1.12.
3. dried residue and extractum are mixed, it is 1.35 that adding distil water is diluted to relative density, and SHANSHEN extractum and residue after mixing are made to wet granular, 70 ℃ of dryings.
4. tabletting is selected rotary tablet machine, and in flakes, specification is the 0.35g*9 sheet, every box 3 plates in compacting.
5. adopt Aluminium-coating Packer to carry out inner packing, with complex pocket and carton, carrying out outer package.
Embodiment 3
1. dried SHANSHEN 2kg is pulverized, cross the 500-800 mesh sieve, by SHANSHEN powder, distilled water, respectively by feed liquid weight ratio 1:20 mixing lixiviate three times, each 20min, filter merging filtrate, residue drying.
2. filtrate is concentrated under 60 ℃ to the extractum that relative density is 1.12.
3. dried residue and extractum are mixed, it is 1.35 that adding distil water is diluted to relative density, and SHANSHEN extractum and residue after mixing are made to wet granular, 70 ℃ of dryings.
4. tabletting is selected rotary tablet machine, and in flakes, specification is the 0.35g*9 sheet, every box 3 plates in compacting.
5. adopt Aluminium-coating Packer to carry out inner packing, with complex pocket and carton, carrying out outer package.
Embodiment 4
1. dried SHANSHEN 2kg is pulverized, cross the 80-150 mesh sieve, by SHANSHEN powder, distilled water, respectively by feed liquid weight ratio 1:20 mixing lixiviate three times, each 40min, filter merging filtrate, residue drying.
2. filtrate is concentrated under 60 ℃ to the extractum that relative density is 1.12.
3. dried residue and extractum are mixed, it is 1.35 that adding distil water is diluted to relative density, and SHANSHEN extractum and residue after mixing are made to wet granular, 70 ℃ of dryings.
4. tabletting is selected rotary tablet machine, and in flakes, specification is the 0.35g*9 sheet, every box 3 plates in compacting.
5. adopt Aluminium-coating Packer to carry out inner packing, with complex pocket and carton, carrying out outer package.
Embodiment 5
1. dried SHANSHEN 2kg is pulverized, cross the 350-500 mesh sieve, by SHANSHEN powder, distilled water, respectively by feed liquid weight ratio 1:20 mixing lixiviate three times, each 40min, filter merging filtrate, residue drying.
2. filtrate is concentrated under 60 ℃ to the extractum that relative density is 1.12.
3. dried residue and extractum are mixed, it is 1.35 that adding distil water is diluted to relative density, and SHANSHEN extractum and residue after mixing are made to wet granular, 70 ℃ of dryings.
4. tabletting is selected rotary tablet machine, and in flakes, specification is the 0.35g*9 sheet, every box 3 plates in compacting.
5. adopt Aluminium-coating Packer to carry out inner packing, with complex pocket and carton, carrying out outer package.
Embodiment 6
1. dried SHANSHEN 2kg is pulverized, cross the 500-800 mesh sieve, by SHANSHEN powder, distilled water, respectively by feed liquid weight ratio 1:20 mixing lixiviate three times, each 40min, filter merging filtrate, residue drying.
2. filtrate is concentrated under 60 ℃ to the extractum that relative density is 1.12.
3. dried residue and extractum are mixed, it is 1.35 that adding distil water is diluted to relative density, and SHANSHEN extractum and residue after mixing are made to wet granular, 70 ℃ of dryings.
4. tabletting is selected rotary tablet machine, and in flakes, specification is the 0.35g*9 sheet, every box 3 plates in compacting.
5. adopt Aluminium-coating Packer to carry out inner packing, with complex pocket and carton, carrying out outer package.
Embodiment 7
1. dried SHANSHEN 2kg is pulverized, cross the 500-800 mesh sieve, by SHANSHEN powder, distilled water, respectively by feed liquid weight ratio 1:20 mixing lixiviate three times, each 60min, filter merging filtrate, residue drying.
2. filtrate is concentrated under 60 ℃ to the extractum that relative density is 1.12.
3. dried residue and extractum are mixed, it is 1.35 that adding distil water is diluted to relative density, and SHANSHEN extractum and residue after mixing are made to wet granular, 70 ℃ of dryings.
4. tabletting is selected rotary tablet machine, and in flakes, specification is the 0.35g*9 sheet, every box 3 plates in compacting.
5. adopt Aluminium-coating Packer to carry out inner packing, with complex pocket and carton, carrying out outer package.
Embodiment 8
1. dried SHANSHEN 2kg is pulverized, cross the 350-500 mesh sieve, by SHANSHEN powder, distilled water, respectively by feed liquid weight ratio 1:20 mixing lixiviate three times, each 60min, filter merging filtrate, residue drying.
2. filtrate is concentrated under 60 ℃ to the extractum that relative density is 1.12.
3. dried residue and extractum are mixed, it is 1.35 that adding distil water is diluted to relative density, and SHANSHEN extractum and residue after mixing are made to wet granular, 70 ℃ of dryings.
4. tabletting is selected rotary tablet machine, and in flakes, specification is the 0.35g*9 sheet, every box 3 plates in compacting.
5. adopt Aluminium-coating Packer to carry out inner packing, with complex pocket and carton, carrying out outer package.
Embodiment 9
1. dried SHANSHEN 2kg is pulverized, cross the 80-150 mesh sieve, by SHANSHEN powder, distilled water, respectively by feed liquid weight ratio 1:20 mixing lixiviate three times, each 60min, filter merging filtrate, residue drying.
2. filtrate is concentrated under 60 ℃ to the extractum that relative density is 1.12.
3. dried residue and extractum are mixed, it is 1.35 that adding distil water is diluted to relative density, and SHANSHEN extractum and residue after mixing are made to wet granular, 70 ℃ of dryings.
4. tabletting is selected rotary tablet machine, and in flakes, specification is the 0.35g*9 sheet, every box 3 plates in compacting.
5. adopt Aluminium-coating Packer to carry out inner packing, with complex pocket and carton, carrying out outer package.
Claims (2)
1. the manufacture method of a pure SHANSHEN buccal tablet, its method is:
A. dried SHANSHEN is pulverized, crossed the 80-800 mesh sieve, SHANSHEN powder, distilled water, by feed liquid weight ratio 1:20 mixing lixiviate three times, more than each 18min, are filtered to merging filtrate, residue drying;
B. filtrate is concentrated under 60 ℃ to the extractum that relative density is 1.10-1.15;
C. dried residue and extractum are mixed, it is 1.3-1.4 that adding distil water is diluted to relative density, and SHANSHEN extractum and residue after mixing are made to wet granular, 68-75 ℃ of drying;
D. select rotary tablet machine, by the wet granular compacting in flakes.
2. the manufacture method of a kind of pure SHANSHEN buccal tablet as claimed in claim 1, its method is: dried SHANSHEN is pulverized to the preferred 80-500 mesh sieve of crossing.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105832791A (en) * | 2015-08-13 | 2016-08-10 | 吉林长白绿叶人参产业有限公司 | Pure under-forest ginseng powder tablet and preparation method thereof |
| CN106072635A (en) * | 2016-06-22 | 2016-11-09 | 运城学院 | A kind of preparation method of Radix Ginseng buccal tablet |
| CN106620412A (en) * | 2016-10-02 | 2017-05-10 | 丁传波 | Preparation method of ginseng and Sedum aizoon L extract |
| CN107801983A (en) * | 2017-11-01 | 2018-03-16 | 延边大学 | A kind of black fungus rich in selenium ginseng lozenge and preparation method thereof |
| CN110448468A (en) * | 2019-07-24 | 2019-11-15 | 上海华源制药安徽广生药业有限公司 | A kind of Chinese medicinal herbal tablets production system and method |
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| CN102805345A (en) * | 2012-08-13 | 2012-12-05 | 吉林省和升圆生物科技有限公司 | Ginseng oral tablet and production process thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105832791A (en) * | 2015-08-13 | 2016-08-10 | 吉林长白绿叶人参产业有限公司 | Pure under-forest ginseng powder tablet and preparation method thereof |
| CN106072635A (en) * | 2016-06-22 | 2016-11-09 | 运城学院 | A kind of preparation method of Radix Ginseng buccal tablet |
| CN106620412A (en) * | 2016-10-02 | 2017-05-10 | 丁传波 | Preparation method of ginseng and Sedum aizoon L extract |
| CN107801983A (en) * | 2017-11-01 | 2018-03-16 | 延边大学 | A kind of black fungus rich in selenium ginseng lozenge and preparation method thereof |
| CN110448468A (en) * | 2019-07-24 | 2019-11-15 | 上海华源制药安徽广生药业有限公司 | A kind of Chinese medicinal herbal tablets production system and method |
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Application publication date: 20131225 |