CN100443113C - Anshenbunao granule and its preparation method - Google Patents
Anshenbunao granule and its preparation method Download PDFInfo
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Abstract
A Chinese medicine 'sedativ and brain-invigorating particles' is prepared from pilose antler, fleece flower root, epimedium, dried ginger, liquorice root, jujube, VB1 and auxiliaries. Its preparing process is also disclosed.
Description
Invention field
The present invention relates to a kind of Chinese medicinal granule preparation, particularly Anshenbunao granule and preparation method thereof.
Background technology
ANSHEN BUNAO YE and Anshen Bunao sheet are widely used nervous system medications, have spermatogenesis and mend marrow, kidney-tonifying and brain tonic, the mental effect of enhancing.Insomnia due to being used to suffer from a deficiency of the kidney, forgetful, diseases such as dizziness, neurasthenia.Its main component is Cornu Cervi Pantotrichum, Radix Polygoni Multiflori Preparata, Herba Epimedii, Rhizoma Zingiberis, Radix Glycyrrhizae, Fructus Jujubae, the plain B1 of giving birth to of dimension etc., discloses prescription, preparation method and the discriminating of Anshen Bunao sheet among the drug standard WS-11154 of the People's Republic of China (PRC) (ZD-1154)-2002.Prescription, preparation method and the discriminating of ANSHEN BUNAO YE are disclosed among the standard WS3-B-0546.Its clinical effectiveness is good.
CN 1362128A discloses a kind of nano tranquilizing and brain nourishing preparation medicine, is the medicament of being made by the nano raw material of following weight proportioning:
Nano-antler 1-10 part, nanometer Radix Polygoni Multiflori Preparata 50-500 part, nanometer Herba Epimedii 100-500 part,
Nanometer Rhizoma Zingiberis 100-500 part, nanometer Radix Glycyrrhizae 50-400 part, nanometer Fructus Jujubae 50-400 part,
The plain living B13-20 part of nanometer dimension,
Adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ~ C, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, in 30--60 ~ C temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.This drug bioavailability height, therapeutic effect is remarkable.
But above-mentioned tablet exists more excipient, and after the compressed molding, dissolution is slow, bioavailability is low; Defectives such as child and comatose patient are difficult for swallowing.Disclosed nano tranquilizing and brain nourishing preparation then is subjected to the restriction of process conditions among the CN 1362128A, is difficult to form reach nano level Chinese medicine preparation.
Summary of the invention
The object of the present invention is to provide a kind of Anshenbunao granule and preparation method thereof, problem such as this granule has overcome that existing Anshen Bunao sheet adjuvant is many, dissolution is slow, bioavailability is low, child and comatose patient are difficult for swallowing, provide a kind of taking convenience, effect rapidly, the Chinese medicine preparation of delicious taste, storage and convenient transportation, preparation method of the present invention is simple, cost is low.
To achieve these goals, the technical solution used in the present invention is: a kind of Anshenbunao granule is to be the granule of effective ingredient preparation by the extract thick paste mixture vitamin that following traditional Chinese medicines is extracted:
Excessive sheep flower bud 600 weight portions of Cornu Cervi Pantotrichum 36 weight portion Radix Polygoni Multiflori Preparatas 750 weight portions
Rhizoma Zingiberis 150 weight portion Radix Glycyrrhizaes 75 weight portion Fructus Jujubaes 150 weight portion VB
16 weight portions.
Also comprise adjuvant in the described granule, described adjuvant is dextrin, mannitol and steviosin, comprises dextrin 200---300 weight portion in the extract thick paste mixture of wherein every 200---400 weight portion, mannitol 550-650 weight portion, steviosin 40-120 weight portion.
Comprise dextrin 200-280 weight portion in the extract thick paste mixture of preferred every 250---350 weight portion, mannitol 580-620 weight portion, steviosin 50-100 weight portion.
Comprise dextrin 220-260 weight portion in the extract thick paste mixture of more preferably every 250---350 weight portion, mannitol 580-620 weight portion, steviosin 50-100 weight portion.
Comprise dextrin 240 weight portions in the extract thick paste mixture of most preferably every 250---350 weight portion, mannitol 600 weight portions, steviosin 50 weight portions.Wherein said extract thick paste mixture relative density is determined as 1.10-1.35 at 60 ℃.
The preparation method of Anshenbunao granule of the present invention comprises the steps:
(1) Rhizoma Zingiberis is extracted volatile oil with steam distillation;
(2) medicinal residues and Radix Polygoni Multiflori Preparata, excessive sheep flower bud, Radix Glycyrrhizae, Fructus Jujubae water extract-alcohol precipitation, filtration, the filtrate recycling ethanol behind the Rhizoma Zingiberis extraction volatile oil gets concentrated solution extractum; Cornu Cervi Pantotrichum water is carried the back concentrated extracting solution, handles the back precipitate with ethanol with Cera Flava, and filtration, filtrate recycling ethanol get Cornu Cervi Pantotrichum concentrated solution extractum; Merge two concentrated solution extractum and get the thick paste mixture;
(3) dextrin, mannitol, steviosin are crossed the 60-100 mesh sieve, and mixing gets mixed accessories;
(4) with VB
1With equivalent progressively increase method and appropriate amount of auxiliary materials mixing;
To remain mixed accessories and mixed VB
1Adjuvant add in the thick paste mixture, mixing, system soft material, granulation, drying, granulate must be done granule, sprays into volatile oil, airtight a few hours;
(5) measure content in the granule;
(6) pack, common every bag heavy 1.0g.
In the preparation method, preferably adopt among the WS-11154 (ZD-1154)-2002 in the disclosed Anshen Bunao sheet and WS3-B-0546 the extracting method of Chinese medicine in the disclosed ANSHEN BUNAO YE.
In the described extracting method, Rhizoma Zingiberis is extracted volatile oil, is with steam distillation or super critical extraction or organic solvent extraction method.
The amount of water that medicinal residues behind the Rhizoma Zingiberis extraction volatile oil and Radix Polygoni Multiflori Preparata, excessive sheep flower bud, Radix Glycyrrhizae, Fructus Jujubae water are carried is 5-20 a times of crude drug, decocting number of times is 1-5 time, the each decoction 1-5 hour, preferred decoction number of times is 2-3 time, the each decoction 2-3 hour, amount of water is 8-12 times, and water is carried the back merging filtrate, and filtrate is concentrated into the extractum that relative density is 1.10-1.38 (60 ℃).
The precipitate with ethanol that Rhizoma Zingiberis is extracted medicinal residues behind the volatile oil and Radix Polygoni Multiflori Preparata, excessive sheep flower bud, Radix Glycyrrhizae, Fructus Jujubae water extract comprises: add ethanol earlier and make and contain alcohol and measure to 50-55%, leave standstill, filter, reclaim ethanol, be concentrated into former extractum amount, adding ethanol again makes and contains alcohol and measure to 60-65%, leave standstill, filter, reclaim ethanol, concentrated solution is standby.
The amount of water that Cornu Cervi Pantotrichum water is carried is 6-18 a times of crude drug, and decocting number of times is 3-8 time, and each 2-5 hour, water was carried the back merging filtrate, and filtrate is concentrated into the extractum that relative density is 1.20-1.30 (70 ℃).
The described processing with Cera Flava comprise add Cera Flava in extractum, leaves standstill to the wax layer to solidify fully, removes dewax layer, filtration.
The precipitate with ethanol of Cornu Cervi Pantotrichum water extracting liquid comprises: add 80% ethanol 50-70ml earlier, left standstill 48 hours, filter, filtrate recycling ethanol, being concentrated into relative density is the clear paste of 1.10-1.20 (60 ℃), adds 80% ethanol 50-70ml again, stirs evenly, leave standstill, 24 hours, filter, filtrate recycling ethanol and above-mentioned concentrated solution merge, mixing is put cold.
In the preparation method of described granule, granulate with 16 mesh sieves, 60 ℃ of dryings, 14 order granulate must be done granule, spray into volatile oil, airtight a few hours, survey content, pack is promptly.
Granule of the present invention is made the dosage of 1 of one bag of dosage that is equivalent to 1 of Anshen Bunao sheet or ANSHEN BUNAO YE, common every bag heavy 1.0g; Each taking dose is 1 bag, 1-2 time on the one.
In the prior art, the adjuvant of preparation granule is mainly sugar part and dextrin, and the proportional force 1: 3: 1 of thick paste, Icing Sugar, dextrin can suitably be adjusted according to the density of extractum, the character of medicine in the general granule.In the granular preparation that has, the consumption of Icing Sugar reaches 6-7 doubly; Or list is made adjuvant with Icing Sugar.The Icing Sugar amount can be 2 times of extractum under a few cases.The 1.2-1.5 of the also promising extractum amount of dextrin dosage doubly.The reason of high like this consumption is that Icing Sugar is the excipient of sol particle preparation and has flavoring concurrently and adhesive effect because in granular preparation.The consumption of Icing Sugar is less than above-mentioned consumption, is difficult to obtain shaped article or is difficult to block the uncomfortable taste of Chinese medicine.And so a large amount of Icing Sugar consumptions is unsuitable for prohibiting sugared patient on the one hand, also causes cost too high in addition.
At pharmaceutical field mannitol is good carrier of freeze-dried powder and excipient, and mannitol also can be used as in the filler of tablet, particularly chewable tablet, mannitol is as diluent, normal and sugar is used, and nice and cool and sweet feel are arranged in the oral cavity, and mannitol still is the short flowable of solid particle.But because mouldability is relatively poor, the mannitol place of sucrose is used for granule and does not also report.
The inventor of this patent is surprised to find that, under suitable consumption, the thick extractum of Chinese medicine extract of the present invention cooperates with dextrin and mannitol, can form the granular preparation that meets medicinal standard, but because the sugariness of mannitol only is the 57-72% of sucrose, the mouthfeel of gained granule is poor slightly, in order to overcome this problem, the steviosin that in this granule, adds a small amount of high sugariness among the present invention, both had good one-tenth graininess, added a spot of sweeting agent, and can cover bitterness again, when steviosin adds to 5%, just can cover bitterness preferably.The mouldability and the melting of each prescription are all qualified, mannitol is compared with sucrose, the mouldability of the two does not have significant difference, because of the granule made from mannitol is difficult for moisture absorption than sucrose, the granule of making is a Sugarless type, help to take in the patient who contains sugar substance and use, so select for use mannitol and dextrin to be used as excipient.Adopt the mannitol place of sucrose among the present invention, its consumption is significantly less than the consumption of sucrose, like this, pharmaceutical composition of the present invention promptly has good grain forming, greatly reduce cost again, the content of granule Chinese medicine active ingredient improves, and taking dose reduces relatively, and the patient uses more convenient.Simultaneously, the present invention provides more dosage form selection for the clinicist, and granule is convenient than tablets, and easy to carry than oral liquid, mouthfeel is better, has improved patient's administration compliance.Granule of the present invention must not decoct when using, and takes after mixing it with hot water and can bring into play curative effect rapidly, for advantage has been created in the emergency case medication.
Describe in detail
Describe the present invention below in detail, described embodiment is used to understand the present invention, rather than restriction the present invention.
Embodiment 1
Prescription is: Cornu Cervi Pantotrichum 36g, Radix Polygoni Multiflori Preparata 750g, excessive sheep flower bud 600g, Rhizoma Zingiberis 150g, Radix Glycyrrhizae 75g, Fructus Jujubae 150g, VB
16g.
According to above-mentioned prescription Rhizoma Zingiberis is extracted volatile oil with steam distillation, medicinal residues and Radix Polygoni Multiflori Preparata, excessive sheep flower bud, Radix Glycyrrhizae, Fructus Jujubae five kinds of Chinese medicine (totally 1725) add water 19kg (about 10 times) and decocted 2 hours, decoct altogether 3 times, each filter, merging filtrate, it is 1.10---1.25 that filtrate is concentrated into relative density, adding ethanol, to make pure content be 50%, left standstill 24 hours, and filtered, reclaim ethanol, be concentrated into former extractum amount, add ethanol and make and contain alcohol amount, left standstill 24 hours, filter to 60%, reclaim ethanol, concentrated solution is standby.
Cornu Cervi Pantotrichum decocts with water five times, first and second time each 4 hours, third and fourth time each 3 hours, the 5th time 2 hours, gradation filtered, and merging filtrate also is concentrated into the clear paste that relative density is 1.20-1.25 (70 ℃), add Cera Flava, leave standstill to the wax layer and solidify fully, remove the dewax layer, filter, add 80% ethanol 50ml, left standstill 48 hours, and filtered filtrate recycling ethanol, being concentrated into relative density is the clear paste of 1.12-1.17 (60 ℃), add 80% ethanol 70ml, stir evenly, left standstill 24 hours, filter, filtrate recycling ethanol and above-mentioned concentrated solution merge, and mixing is put cold.
(1) dextrin 200g, mannitol 640g, steviosin 40g are crossed 80 mesh sieves, mixing gets mixed accessories.
(2) with VB
1With equivalent progressively increase method and appropriate amount of auxiliary materials mixing;
(3) will remain mixed accessories and mixed VB
1Adjuvant add in the thick paste mixture, mixing, the system soft material, 16 orders are granulated, 60 ℃ of dryings, 14 order granulate must be done granule, spray into volatile oil, airtight a few hours;
(4) pack, every bag heavy 1.0g.
Embodiment 2-5
Method with reference to embodiment 1 prepares Anshenbunao granule of the present invention, and concrete technological parameter sees Table 1:
Table 1
The extraction process by water of the foregoing description five tastes medicine has good repeatability, and water is put forward the dried cream yield in back and seen Table 2.
The experiment of table 2 extraction process by water repeatability
The above results shows that preparation method of the present invention has good repeatability, and extraction process by water of the present invention is stablized feasible.
Precipitate with ethanol is Chinese medicine preparation purification, deimpurity common method.Take by weighing 1/5th of the former prescription of medical material in the prescription ratio, decoct with water twice, 2 hours for the first time, 2 hours for the second time.Collecting decoction filters, and it is the clear paste of 1.25-1.32 (50 ℃) that concentrating filter liquor becomes relative density, and extractum is divided into four parts, adds Different concentrations of alcohol respectively, and content is changed in gradient to investigate removal of impurity effect.
Find in the test, carry out precipitate with ethanol with the 50-55% determining alcohol, its dried cream does not have significant difference (P＞0.1), carry out precipitate with ethanol with the 60-65% determining alcohol, its dried cream does not have significant difference (P＞0.1), for reducing dose, removes more impurity and reduces the ethanol consumption simultaneously, preferred 50% ethanol of use for the first time, the second time with 65% ethanol as alcohol precipitation process.
Extraction ratio:
For showing that precipitate with ethanol removes the effect of impurity, the water extracted immersing paste and 65% precipitate with ethanol extractum are compared, measure its dried cream extraction ratio, (inventory be recipe quantity 1/5th): the results are shown in Table 3.
Table 3 is the result show, the extraction ratio of 65% precipitate with ethanol extractum is 34.0% of a water extracted immersing paste, removed most of impurity, reduced dose.
Table 3 the water extracted immersing paste and 65% precipitate with ethanol extractum extraction ratio are relatively
Anshen Bunao granule preparing process of the present invention is according to the big condition of production, employing is carried based on water, suitably add the alcohol precipitation and remove protein, impurity such as starch, resin extract effective ingredient to reach, reduce dose, reduce the ethanol consumption, reduce the purpose of impurity, through test and Selection, wherein Chinese medicine of the five flavours water carry with twice for good, Cornu Cervi Pantotrichum water is carried with five times to good.
Embodiment 6
According to the requirement of granular preparation general rule, in conjunction with this medicine characteristics, select these several indexs of outward appearance, hardness, flowability, disintegration among the present invention, write out a prescription and craft screening.The factor that influences the quality of granule mainly contains: (1) uniformity, color consistency, (2) granularity, (3) loss on drying, (4) melting, (5) content uniformity.It is bigger to granularity, the melting influence of granule wherein to write out a prescription; Because this product is to take after mixing it with water when taking, so also should consider mouthfeel during optimizing prescriptions.In view of the above, we are index with granularity, melting, the mouthfeel of granule, carry out prescription screening." granularity " sees molding particles, and " melting " measured the 10g granule by official method and added hot water 200ml whether be dispersed into time of solution qualified; Mouthfeel is divided into: poor, general, better, good, excellent five grades are estimated.
In the prior art, the Anshen Bunao tablet adopts thick paste to add the method for adjuvant granulation, drying, tabletting, and for keeping preparation process consistent with tablet, granule also adopts thick paste to add adjuvant granulation, exsiccant method.1000 bags of this product amount extract thick paste mixture after drying, the about 200-400g of thick paste, the about 100-200g of dried cream draws up into the granule of every bag of 1g.
Prescription screening the results are shown in Table 4, and thick paste extract wherein is the medical material that takes by weighing 6 times of recipe quantities, extracts the extract of gained according to the technological parameter of embodiment 1, divides equally to be 6 parts and to be used for this experiment again.Extract for embodiment 2-5 also repeats same experiment respectively.
Table 4 Anshenbunao granule prescription screening result of the test (recipe quantity: 1000 bags)
Result of the test shows that mouthfeel was relatively poor when list was used dextrin and mannitol, and is good than the mannitol mouthfeel with sucrose, then can cover bitterness with steviosin, when steviosin adds to 5%, just can cover bitterness preferably.The mouldability and the melting of each prescription are all qualified, mannitol is compared with sucrose, the mouldability of the two does not have significant difference, because of the granule made from mannitol is difficult for moisture absorption than sucrose, the granule of making is a Sugarless type, help to take in the patient who contains sugar substance and use, so select for use mannitol and dextrin to be used as excipient.According to last watch test result, 5 and 6 better to write out a prescription, the more a spot of steviosin of prescription 5 usefulness just can reach 6 the effect of writing out a prescription.
Change mannitol and dextrin dosage respectively, also can access qualified granule, referring to table 5
Table 5 Anshenbunao granule prescription screening result of the test (recipe quantity: 1000 bags)
Embodiment 2-5 also obtains identical result substantially.
Embodiment 7
Take by weighing the medical material of 1 times, 5 times, 10 times, 20 times recipe quantity respectively, extract extractum, make Anshen Bunao granule of the present invention according to preferred prescription according to preferred technology.
Method according to standard code, to embodiment of the invention 1-6 gained totally ten batches the Anshen Bunao granule its carry out 2,3,5, the assay of 4 '-tetrahydroxystilbene-2-O-β-D glucoside, content are respectively 2.45,2.17,2.36,2.23,2.31,2.27,2.14,2.16,2.19,2.16mg, (every contains 2 with commercially available prod Anshen Bunao sheet, 3,5,4 '-tetrahydroxystilbene-2-O-β-D glucoside must not be less than 2mg) unanimity.Embodiment 2-5 also obtains identical result substantially.
Embodiment 8
The Anshen Bunao granule that adopts the embodiment of the invention to obtain, during assay, reference substance adopt that Nat'l Pharmaceutical ﹠ Biological Products Control Institute provides 2,3,5,4 '-tetrahydroxystilbene-2-O-β-D glucose.
Content of the test and condition
1 preliminarily stabilised test
With the sample of each embodiment simulation listing packing (aluminium plastic bag is an inner packing, and outer package is a carton), under 40 ℃, relative humidity 75% condition, preserve, respectively at 0,1,2, March sampling and measuring.
2 long term tests
With 3 batch samples simulation listing packing (aluminium plastic bag is an inner packing, and outer package is a carton), put under 25 ℃, humidity 60% condition, respectively at 0,3,6,12,18,24 months sampling and measuring.
3 investigation project and requirements
To the requirement of granule stability assessment project, the present invention tests projects such as the character of Anshen Bunao, discriminating, melting, assays in requiring according to the new Chinese medicine stability test.
Result and conclusion
1 preliminarily stabilised
Embodiment 4-5 and The above results are basic identical, and concrete data slightly.
2. long-time stability
Embodiment 4-5 and The above results are basic identical, and concrete data slightly.
3. conclusion
3.1 preliminarily stabilised conclusion
Accelerated test result shows under the condition of 40 ℃ of temperature and humidity 75%, and 0,1,2, investigate March, finds that character, melting, moisture, the assay of 3 batch samples is all qualified, product is stable.
3.2 long term test conclusion
Under simulation commercially available back condition, put under 25 ℃, humidity 60% condition, in the time of 0,3,6,12,18,24 month, investigate respectively, find that character, melting, moisture, the assay of 3 batch samples is all qualified, product does not have to be enough to influence the variation of drug quality, and product is stable.
Pharmacodynamic experiment shows that Anshenbunao granule of the present invention has Anshen Bunao sheet and the same drug effect of ANSHEN BUNAO YE, and onset is fast than tablet, and patient Geng Yi accepts.
Claims (13)
1. Anshenbunao granule is that extract thick paste mixture and the vitamin that is extracted by following traditional Chinese medicines is the granule of effective ingredient preparation:
Described Chinese medicine is Cornu Cervi Pantotrichum 36 weight portion Radix Polygoni Multiflori Preparatas 750 weight portion Herba Epimedii 600 weight portion Rhizoma Zingiberiss 150 weight portion Radix Glycyrrhizaes 75 weight portion Fructus Jujubaes 150 weight portions
Described vitamin is VB
16 heavy x amount parts
Also comprise adjuvant in the described granule, described adjuvant is dextrin, mannitol and steviosin, comprises dextrin 200---300 weight portion in the extract thick paste mixture of wherein every 200---400 weight portion, mannitol 550-650 weight portion, steviosin 40-120 weight portion.
2. Anshenbunao granule according to claim 1 comprises dextrin 200-280 weight portion in the extract thick paste mixture of wherein every 250---350 weight portion, mannitol 580-620 weight portion, steviosin 50-100 weight portion.
3. Anshenbunao granule according to claim 2 comprises dextrin 220-260 weight portion in the extract thick paste mixture of wherein every 250---350 weight portion, mannitol 580-620 weight portion, steviosin 50-100 weight portion.
4. Anshenbunao granule according to claim 3 comprises dextrin 240 weight portions in the extract thick paste mixture of wherein every 250---350 weight portion, mannitol 600 weight portions, steviosin 50 weight portions.
5. Anshenbunao granule according to claim 1, wherein said extract thick paste mixture relative density is determined as 1.10-1.35 at 60 ℃.
6. the preparation method of the described Anshenbunao granule of claim 1 comprises the steps:
(1) by recipe quantity Rhizoma Zingiberis is extracted volatile oil, medicinal residues get concentrated solution extractum with Radix Polygoni Multiflori Preparata, excessive sheep flower bud, Radix Glycyrrhizae, Fructus Jujubae water extract-alcohol precipitation, filtration, filtrate recycling ethanol; Cornu Cervi Pantotrichum water is carried the back concentrated extracting solution, handles the back precipitate with ethanol with Cera Flava, and filtration, filtrate recycling ethanol get Cornu Cervi Pantotrichum concentrated solution extractum; Merge two concentrated solution extractum and get the thick paste mixture;
(2) dextrin, mannitol, steviosin are crossed the 60-100 mesh sieve, mixing gets mixed accessories;
(3) with VB
1With equivalent progressively increase method and appropriate amount of auxiliary materials mixing;
(4) will remain mixed accessories and mixed VB
1Adjuvant add in the thick paste mixture, mixing, system soft material, granulation, drying, granulate must be done granule;
(5) spray into volatile oil, airtight a few hours;
(6) pack.
7. the preparation method of Anshenbunao granule according to claim 6, wherein Rhizoma Zingiberis is extracted volatile oil, is with steam distillation or super critical extraction or organic solvent extraction method.
8. the preparation method of Anshenbunao granule according to claim 6, wherein Rhizoma Zingiberis to extract the amount of water that medicinal residues and Radix Polygoni Multiflori Preparata, Herba Epimedii, Radix Glycyrrhizae, Fructus Jujubae water behind the volatile oil carries be 5-20 times of crude drug, decocting number of times is 1-5 time, the each decoction 1-5 hour, water is carried the back merging filtrate, and filtrate is concentrated into the extractum that relative density is 1.10-1.38.
9. the preparation method of Anshenbunao granule according to claim 8, wherein said amount of water be crude drug 8-12 doubly, decocting number of times is 2-3 time, decocts 2-3 hour at every turn.
10. the preparation method of Anshenbunao granule according to claim 6, wherein Rhizoma Zingiberis is extracted medicinal residues behind the volatile oil and carries afterwards with Radix Polygoni Multiflori Preparata, Herba Epimedii, Radix Glycyrrhizae, Fructus Jujubae water that the precipitate with ethanol of concentrated solution comprises: add ethanol earlier and make and contain alcohol and measure to 50-55%, leave standstill, filter, reclaim ethanol, be concentrated into former extractum amount, adding ethanol again makes and contains alcohol and measure to 60-65%, leave standstill, filter, it is standby that recovery ethanol gets concentrated solution.
11. the preparation method of Anshenbunao granule according to claim 6, wherein the amount of water carried of Cornu Cervi Pantotrichum water be crude drug 6-18 doubly, decocting number of times is 3-8 time, 2-5 hour at every turn, water is carried the back merging filtrate, and filtrate is concentrated into the extractum that relative density is 1.20-1.30.
12. the preparation method of Anshenbunao granule according to claim 6, the wherein said processing with Cera Flava comprise add Cera Flava in extractum, leaves standstill to the wax layer to solidify fully, removes dewax layer, filtration.
13. the preparation method of Anshenbunao granule according to claim 6, wherein the precipitate with ethanol of Cornu Cervi Pantotrichum comprises: add 80% ethanol 50-70ml earlier, left standstill 48 hours, filter, filtrate recycling ethanol, being concentrated into relative density is the clear paste of 1.10-1.20 (60 ℃), add 80% ethanol 50-70ml again, stir evenly, leave standstill, 24 hours, filter, filtrate recycling ethanol and above-mentioned concentrated solution merge, and mixing is put cold.
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| CN107582947A (en) * | 2017-09-30 | 2018-01-16 | 莱芜房干康复医院 | A kind of Chinese medicine composition of intelligence development cerebrum tonifying and preparation method thereof |
| CN115089685A (en) * | 2022-03-01 | 2022-09-23 | 江苏聚荣制药集团有限公司 | Sugar-free nerve-soothing and brain-nourishing liquid and preparation method thereof |
| CN116098962A (en) * | 2022-12-16 | 2023-05-12 | 无锡济煜山禾药业股份有限公司 | Preparation method of life-prolonging and body-building particles |
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| Title |
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| ***药品标准中药成方制剂第三册. 药典委员会，78. 1991 |
| ***药品标准中药成方制剂第三册. 药典委员会，78. 1991 * |
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