CN104147394A - Dendrobium candidum compound preparation and preparation method thereof - Google Patents
Dendrobium candidum compound preparation and preparation method thereof Download PDFInfo
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Abstract
The invention provides a dendrobium candidum compound preparation, a preparation method thereof, and an application thereof in preparation of drugs or health-caring products for promoting sleep. The compound preparation is composed with dendrobium candidum and gastrodia elata as main components matched with medicines comprising platycladi seeds, spina date seeds, caulis polygoni multiflori, fructus lycii and the like. The main components and the medicines are parepared into a powder, an extract or a preparation which is prepared with addition of pharmaceutically acceptable auxiliary materials or auxiliary ingredients. The dendrobium candidum compound preparation can effectively promote sleep, can improve sleep status, can enhance immunity, is definite in curative effects, is free of addiction and dependence and is free of toxic and side effects.
Description
Technical field:
The invention belongs to field of medicine preparing technology.The present invention relates to specifically Herba Dendrobii compound preparation and preparation method thereof.
Background technology:
Sleep disorder and even insomnia are the common a kind of diseases of Modern human populations, are the length of one's sleep or sleep quality are not met and affect a kind of subjective experience of routine work life.Sleep disorder has transience, also has for a long time, and along with social rhythm accelerates, stress increases, and the sickness rate of sleep disorder is sharply ascendant trend.Long-term sleep disorder can affect people's brain function and blood pressure, needs medicine conditioning and health care to intervene.Meanwhile, sleep also has very important effect for the immunity of human body, and research shows, sleep deprivation person, and in its body, NK cell value significantly reduces, immunity degradation; Long-term sleep disorder crowd, its immunity is generally on the low side.The medicine of at present conventional treatment sleep disorder is mainly synthetic chemistry medicine, and as Benzodiazepines sedative hypnotics, this class medicine has certain addiction and side effect, for prolonged application, still has some restrictions.And treatment by Chinese herbs sleep disorder is because its composition is various, action target spot is multiple, and the low feature of toxic and side effects is valued by the people recently day by day relatively.
Herba Dendrobii medicinal history is long, and < < Chinese Pharmacopoeia > > one of version in 2010 records Herba Dendrobii reinforcing stomach reg fluid, nourishing YIN and clearing away heat.It sinks is a kind of famous and precious Chinese crude drug, has neuroprotective cell, convulsion, calmness, the effects such as hypnosis.This two tastes Chinese medicine is all the orchid family Common Medicinal Herbs, and Papillary, is equipped with the medical materials such as Semen Platycladi, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Fructus Lycii, function nourishing YIN and clearing away heat, and mind tranquilizing and the heart calming, has hypnotic effect, for treatment of sleep disorders and auxiliary health care.Meanwhile, Herba Dendrobii, Rhizoma Gastrodiae, Fructus Lycii etc. are rich in polysaccharide, have been proved to be able to strengthen body immunity, and compound recipe is used, and can reach and promote to improve sleep to strengthen the effect of body immunity.
At present, research and development about Herba Dendrobii compound preparation are mainly utilizing on the immunity potentiation of Dendrobium officinale polysaccharide, the compatibility uses such as many and Radix Panacis Quinquefolii, be used for strengthening body immunity, have no the compound preparation report that utilizes Herba Dendrobii prescription to strengthen from improving the further exciting human immunity of sleep angle.
Summary of the invention:
The technical problem to be solved in the present invention is to provide a kind of Herba Dendrobii and Rhizoma Gastrodiae is master's compound, the present invention is from sleep improvement angle, utilize the effect of Herba Dendrobii YIN nourishing, be used in conjunction with this traditional suppressing the hyperactive liver to relieve the wind syndrome Chinese medicine of Rhizoma Gastrodiae, add the yin nourishing spirit quieting medicines such as Semen Platycladi, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Fructus Lycii, improve sleep with the lifting of exciting human immunity, while is by the effect of Herba Dendrobii, Rhizoma Gastrodiae, lycium barbarum polysaccharide, reach inside and outside minor, strengthen the object of body immunity.The present invention carries out hypnotic product development with Herba Dendrobii prescription first, obtains the health-care product of effective hypnotic, raising immunity.
In order to realize above-mentioned purpose of the present invention, the invention provides following technical scheme:
A Herba Dendrobii compound preparation, this compound preparation is composed of the following components by weight percentage, and the summation of each component equals 100%,
As described in a kind of Herba Dendrobii compound preparation, this compound preparation is directly to pulverize by described each component the powder forming, or the extractum that obtains via water or organic solvent extraction of described each component, or the pharmaceutical preparation that is prepared from of the excipient substance of the extract of described each component that is 10%～90% by percentage by weight and 90%～10% or complementary composition.
As described in a kind of Herba Dendrobii compound preparation, every 100 grams of the powdered extract of each component extract of described Herba Dendrobii is greater than 10 grams containing polysaccharide, every 100 grams are greater than 0.05 gram containing gastrodine.
Described compound preparation is being prepared hypnotic or/and the application in the medicine for the treatment of sleep disorder.
Described compound preparation is being prepared hypnotic or/and the application in the health product for the treatment of sleep disorder.
The application of described compound preparation in preparing the health product of enhancing immunity.
The preparation method of described compound preparation, the method comprises the steps:
A, Herba Dendrobii, Rhizoma Gastrodiae, Semen Platycladi, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Fructus Lycii are directly beaten to powder obtain powder; Or will after above-mentioned pulverizing medicinal materials, with hot-water soak, extract, after gained water extraction liquid recycle-water, obtain compound extract extractum; Or by after above-mentioned pulverizing medicinal materials with 20%～95% alcohol reflux, gained extracting solution reclaims after solvent to obtain compound extract extractum;
B, add pharmaceutically acceptable adjuvant or complementary composition to be prepared into common dosage forms pharmaceutically a gained compound recipe medicinal powder or extract extractum.
As described in a kind of Herba Dendrobii compound preparation, described powder refers to that medicine is through being crushed to micropowders more than 300 orders.
The preparation method of described compound preparation, the method comprises the steps:
The medical materials such as Herba Dendrobii, Rhizoma Gastrodiae, Semen Platycladi, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Fructus Lycii are made a call to 100 order powder, water or organic solvent extraction obtain pharmaceutical composition extractum, add again the agent of pharmaceutically acceptable carrier granulation, granule is packed into and in capsulae vacuus, obtains capsule, granule is pressed into sheet and obtains tablet, tablet carries out film coating outward and obtains coated tablet; Pharmaceutical composition extract extractum adds diluent standardize solution to obtain tincture and oral liquid; 70% ethanol sterilizing for pharmaceutical composition, carries out micronizing and obtains powder.
Herba Dendrobii compound preparation disclosed by the invention is comprised of Herba Dendrobii, Rhizoma Gastrodiae, Semen Platycladi, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Fructus Lycii, the powder that adopts micropowder technology to be directly ground into by these medical materials; Or the extractum obtaining via water or organic solvent extraction; Or the pharmaceutical preparation that is prepared from of the compound extract that is 10%～90% by percentage by weight and 90%～10% adjuvant or complementary composition.Wherein compound recipe is configured to Herba Dendrobii 10%～50%, Rhizoma Gastrodiae 10%～50%, Semen Platycladi 5%～30%, Semen Ziziphi Spinosae 5%～30%, Caulis Polygoni Multiflori 5%～30%, Fructus Lycii 5%～30%.Compound recipe medicinal substances extract powdered extract polyoses content is greater than 10%, containing gastrodin content, is greater than 0.05%.
Pharmaceutical preparation of the present invention is oral powder, extractum, granule, capsule, tablet, tincture, oral liquid.Pharmaceutically acceptable carrier of the present invention refers to the pharmaceutical carrier of pharmaceutical field routine, such as: diluent, excipient are as water etc., and filler is as starch, sucrose etc.; Adhesive is as cellulose derivative, alginate, gelatin and polyvinylpyrrolidone; Wetting agent is as glycerol; Disintegrating agent is as agar, calcium carbonate and sodium bicarbonate; Absorption enhancer is as quaternary ammonium compound; Surfactant is as hexadecanol; Absorption carrier is as Kaolin and soap clay; Lubricant is as Pulvis Talci, calcium stearate and magnesium and and Polyethylene Glycol etc.Can also in compositions, add in addition other adjuvant as flavouring agent, sweeting agent etc.
Dosage of the present invention is for being equivalent to polysaccharide 100～500mg/ time, gastrodine aglycon 2～30mg/ time.
Compare with prior art or product, tool of the present invention has the following advantages:
1. product involved in the present invention major ingredient Herba Dendrobii used nourishing YIN and clearing away heat, can effectively improve human body function, enhancing immunity, be equipped with the tranquillizing and allaying excitement medical materials such as Rhizoma Gastrodiae, Semen Platycladi, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Fructus Lycii, and product active constituent content is high, can effectively improve the human body mental status, alleviate psychentonia and pressure, make human body be easier to enter sleep state, obtain better sleep quality, recover condition.
2. product preparation method involved in the present invention, does not need to add any non-nutrition or functional additive, and it is, while extracting solvent, to belong to all-natural product that production process makes water, and safe and sanitary, without the side effect producing because of foreign substance.
3. product preparation method involved in the present invention, simple and easy to do, and production cost is low, and compound preparation medical material utilization rate used is high, good in economic efficiency.
4. technical process involved in the present invention is without sewage, toxic emission, and medical material slag can also be done it again and use (as functional food, feedstuff etc.).
5. product purpose involved in the present invention is extensive, both can be used as intermediate for the exploitation of Herba Dendrobii medicine series, also can be directly as health product human consumption.
Herba Dendrobii compound preparation of the present invention is comprised of common Chinese medicine, and pertinent literature and forefathers' Research foundation show that these herbal toxic effects are low, without teratogenesis, mutagenesis.
The specific embodiment:
With embodiments of the invention, further illustrate essentiality content of the present invention below, but also limit never in any form the present invention.
Embodiment 1:
Herba Dendrobii: 150 grams; Rhizoma Gastrodiae: 80 grams; Semen Platycladi: 60 grams; Semen Ziziphi Spinosae: 100 grams; Caulis Polygoni Multiflori: 60 grams; Fructus Lycii: 100 grams.Above 6 tastes, decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, decocting liquid filtered, and merged, concentrated, obtained 204.1 grams of extractum, extraction ratio: 38.51%.
Gained extractum is got 10 grams, with 50 milliliter of 40% dissolve with ethanol, adds 5 grams of lactose, 2.5 grams of mannose, and 80 grams of soluble starches, with 20 mesh sieve hole wet granulations, dry shaping, crosses 20 mesh sieve holes and obtains 90 grams of granules.
Embodiment 2:
Herba Dendrobii: 600 grams; Rhizoma Gastrodiae: 300 grams; Semen Platycladi: 180 grams; Semen Ziziphi Spinosae: 100 grams; Caulis Polygoni Multiflori: 180 grams; Fructus Lycii: 100 grams.
Get above 6 taste Chinese medicinal powder, decoct with water secondary.The water that adds for the first time 12 times of amounts, decocts 3h; The water of the 2nd 10 times of amounts, decoct 2h, merge 2 times decoction liquor, precipitation 24h, filter, get filtrate, concentrating under reduced pressure becomes relative density to 1.20～1.28 (60 ℃), it is 50% that stirring descends to delay to add ethanol to make containing alcohol amount, Cryoprecipitation 24h, filters, and gets the above thick paste of the concentrated relative density to 1.35 (80 ℃) of filtrate decompression, decompression drying, be ground into fine powder (crossing 100 mesh sieves), get fine powder and add recipe quantity propylene glycol and PEG 400, mix, incapsulate, obtain 1000 of capsules, pack.
Embodiment 3:
Herba Dendrobii: 600 grams; Rhizoma Gastrodiae: 300 grams; Semen Platycladi: 180 grams; Semen Ziziphi Spinosae: 100 grams; Caulis Polygoni Multiflori: 180 grams; Fructus Lycii: 100 grams.
Get above 6 taste Chinese medicinal powder, 70% alcohol reflux 2 times, each 2h, filters, and is concentrated into after the extractum of relative density 1.20 standby after filtrate recycling ethanol; Residue decocts with water 2h twice, the 1 time, the 2nd 1.5h, and collecting decoction, is concentrated into after the extractum of relative density 1.2 standby.By appropriate amount of starch, dextrin, be placed in suitable vessel, add hot dipping cream; stir rapidly, make soft material, in oscillating granulator, make wet granular; granule is spread out in suitable vessel (use to be dried), and baking temperature is 60 ℃, in dry run, will stir in time granule; dried granule is toward sieving granulate; after granulate, add magnesium stearate, mix, calculate the heavy rear tabletting of sheet; obtain 2000, tablet, pack.
Embodiment 4:
With the Herba Dendrobii compound recipe extraction extractum of the above embodiment of the present invention 1, carry out hypnotic zoopery:
1, object
Adopt the sub-threshold dose method of pentobarbital sodium, it is the sleep peacefully sedative-hypnotic effect of sheet, Chinese medicine compound of the index evaluation evaluation that enters to sleep above that the mice righting reflex loss of take reaches 1min.
2, experiment material
2.1 laboratory samples:
The sheet (tablet, pulverizes, and crosses 100 mesh sieves) of sleeping peacefully
Chinese medicine compound, extraction ratio: 38.5%
2.2 medicines and reagent
Diazepam (every of stable content 2.5mg/)
Pentobarbital sodium: BIOSHARP, lot number: 821028
Normal saline: SIGMA ALDRICH, lot number: 050M0135V.
Tween 20 (guaranteed reagent RG): Beijing Suo Laibao Science and Technology Ltd., lot number: T8220.
2.3 experimental apparatus
Electronic analytical balance: PrecisaXS125A.
Electronic balance: Yuyao City Jin Nuo balance equipment company limited.
ZZ-6 mice autonomic activities tester: Chengdu TME Technology Co., Ltd.
2.4 laboratory animal
Kunming mouse, clean level, body weight 18g-24g, male and female half and half, by Kunming, medical university provides.The quality certification number: SCXK (river) 2008-24 lot number: Dossy2012-4.
The preparation of 2.5 stocks of drugs
1. the configuration of pentobarbital sodium 60mg/kg mother solution: every mice is pressed the administration of 0.2ml/10g volume, required pentobarbital sodium solution concentration is: 60mg/20ml=3mg/ml, according to 96 of mices used, every about 25g of body weight, estimation will be with pentobarbital sodium liquor capacity: 0.2ml/10g * 25g * 96=48ml, required pentobarbital sodium is quality 3mg/ml * 48ml=144mg.
Join method: precision takes pentobarbital sodium 144mg, and normal saline is dissolved to 48ml.
2. the sleep peacefully configuration of sheet: dosage: high dose is 1.2g/kg, middle dosage is 900mg/kg, low dosage is 600mg/kg, every mice is pressed the administration of 0.2ml/10g volume, administration concentration is high dose 60mg/ml, middle dosage 45mg/ml, low dosage 30mg/ml, the volume that needs altogether variable concentrations medicinal liquid is 25g/ * 12 * 1 day * 0.2ml/10g=6ml, the required tablet quality of sleeping peacefully is high dose 60mg/ml * 6ml=360mg, middle dosage 45mg/ml * 6ml=270mg, 30mg/ml * 6ml=180mg.
Join method: precision takes constant weight thing 360mg in beaker, with liquid-transfering gun, getting tween 20 and distilled water on a small quantity slowly (prevents emulsifying) equal-volume adds in beaker, when adding tween 20 3ml, fully dissolve, this liquid is transferred in graduated cylinder, with distilled water, be dissolved to 6ml.
3. diazepam configuration: dosage is 50mg/kg, and every mice is pressed the administration of 0.2ml/10g volume, and administration concentration is 2.5mg/ml.Every day, the volume of required medicinal liquid was 25g/ * 12 * 0.2ml/10g=6ml, and required stable quality is 15mg (needing 6 diazepams).
Join method: get and stabilize 6 in beaker, grind, with liquid-transfering gun, get tween 20 and distilled water and on a small quantity slowly (prevent emulsifying) equal-volume adds in beaker, when adding tween 20 3ml, fully dissolve, this liquid is transferred in graduated cylinder, with distilled water, is dissolved to 6ml.
4. with 2 Chinese medicine compound configurations: get extractum 360mg, add same volume hot water, be settled to 6ml.
5. contain the configuration of the distilled water of tween 20: with graduated cylinder, get normal saline 3ml, add tween 20 3ml, fully dissolve, distilled water is settled to 15ml.
Note: equal 4 ℃ of preservations after above medicinal liquid prepares
3, experimental technique
3.1 animal groupings (in testing the previous day)
Get 96 of healthy Kunming mouses, male and female half and half, are divided into 8 groups following (shown in table 1) at random:
The grouping of table 1 Kunming mouse
| Kunming mouse sum adds up to | Kunming mouse packet count |
| 96 of mices (male and female half and half) | 12 (male and female half and half) of blank group |
| ? | 12 (male and female half and half) of positive group |
| ? | 12 of the sheet low dosages (male and female half and half) of sleeping peacefully |
| ? | 12 of the dosage (male and female half and half) in sheet of sleeping peacefully |
| ? | 12 of the sheet high doses (male and female half and half) of sleeping peacefully |
| ? | 12 of compound recipe low dosages (male and female half and half) |
| ? | 12 of dosage (male and female half and half) in compound recipe |
| ? | 12 of compound recipe high doses (male and female half and half) |
3.2 animals administer
Before doing formal experiment, with 12 mices, first carry out preliminary experiment, determine pentobarbital sodium sub-threshold lull dosage (pentobarbital sodium 40mg/kg body weight), with this dosage, formally test.Before administration, water 6h is can't help in fasting, every mice is pressed 0.2ml/10g volume gastric infusion, respectively by high, normal, basic dosed administration, administration 7 days, after each administration, test mice autonomic activities number of times half an hour, and mice was put into respectively in autonomic activities tester after 5 minutes, start to record movable number of times in mice 2 minutes, pentobarbital sodium in 1 hour pneumoretroperitoneum injection sub-threshold dose of last administration, reaches 1min above for entering to sleep index with righting reflex loss, observes the number of elements of falling asleep of respectively organizing mice.
4, experimental result
Experimental result in Table 2, table 3.
Table 2 mice autonomic activities test result
| Group | Total mice | Movable number of times | The number of times of standing |
| Blank group | 12 | 3.33±2.348 | 25.25±6.797 |
| Positive controls | 12 | 1.20±2.251 | 3.30±5.229 |
| The sheet low dose group of sleeping peacefully | 11 | 3.36±2.501 | 18.55±13.859 |
| The dosage group in sheet of sleeping peacefully | 12 | 4.45±4.132 | 11.45±8.847 |
| The sheet high dose group of sleeping peacefully | 12 | 3.50±2.576 | 11.83±10.786 |
| Chinese medicine compound low dose group | 12 | 2.00±1.348 | 15.67±7.947 |
| Dosage group in Chinese medicine compound | 12 | 2.50±3.503 | 11.83±8.657 |
| Chinese medicine compound high dose group | 12 | 2.08±2.251 | 10.33±7.303 |
The table 3 mice rate test result of falling asleep
| Group | Total mice | The number of elements of falling asleep | The rate of falling asleep % |
| Blank group | 12 | 2 | 16.7 |
| Positive controls | 12 | 12 | 100 |
| The sheet low dose group of sleeping peacefully | 11 | 4 | 36.4 |
| The dosage group in sheet of sleeping peacefully | 12 | 5 | 41.6 |
| The sheet high dose group of sleeping peacefully | 12 | 7 | 58.3 |
| Chinese medicine compound low dose group | 12 | 6 | 50 |
| Dosage group in Chinese medicine compound | 12 | 6 | 50 |
| Chinese medicine compound high dose group | 12 | 7 | 58.3 |
From experimental result, can find out, by the Herba Dendrobii compound extract of embodiment 1 preparation, can obviously reduce the movable number of times of mice, the number of times of standing, with blank significant difference.By the Herba Dendrobii compound extract of embodiment 1 preparation, carry out and promote the experiment of falling asleep of pentobarbital sodium sub-threshold lull dosage mice to show: 1, Herba Dendrobii compound recipe group hypnotic effect with now with the sheet comparison of sleeping peacefully of accurate font size medicine, during p=0.05, difference is not remarkable, 2, Herba Dendrobii compound recipe group is compared with matched group, p=0.05 and 0.01 o'clock, difference was all extremely remarkable.Show effectively hypnotic of Herba Dendrobii compound recipe of the present invention, its hypnotic effect and the accurate font size medicine sheet of sleeping peacefully is suitable.
Claims (9)
1. a Herba Dendrobii compound preparation, this compound preparation is composed of the following components by weight percentage, and the summation of each component equals 100%,
2. a kind of Herba Dendrobii compound preparation as claimed in claim 1, it is characterized in that this compound preparation is directly to pulverize by described each component the powder forming, or the extractum that obtains via water or organic solvent extraction of described each component, or the pharmaceutical preparation that is prepared from of the excipient substance of the extract of described each component that is 10%～90% by percentage by weight and 90%～10% or complementary composition.
3. a kind of Herba Dendrobii compound preparation as claimed in claim 1, is characterized in that: every 100 grams of the powdered extract of each component extract of described Herba Dendrobii is greater than 10 grams containing polysaccharide, and every 100 grams are greater than 0.05 gram containing gastrodine.
4. the compound preparation described in claim 1 or 2 or 3 is being prepared hypnotic or/and the application in the medicine for the treatment of sleep disorder.
5. the compound preparation described in claim 1 or 2 or 3 is being prepared hypnotic or/and the application in the health product for the treatment of sleep disorder.
6. the application of the compound preparation described in claim 1 or 2 or 3 in preparing the health product of enhancing immunity.
7. the preparation method of the compound preparation described in claim 1 or 2 or 3, is characterized in that the method comprises the steps:
A, Herba Dendrobii, Rhizoma Gastrodiae, Semen Platycladi, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Fructus Lycii are directly beaten to powder obtain powder; Or will after above-mentioned pulverizing medicinal materials, with hot-water soak, extract, after gained water extraction liquid recycle-water, obtain compound extract extractum; Or by after above-mentioned pulverizing medicinal materials with 20%～95% alcohol reflux, gained extracting solution reclaims after solvent to obtain compound extract extractum;
B, add pharmaceutically acceptable adjuvant or complementary composition to be prepared into common dosage forms pharmaceutically a gained compound recipe medicinal powder or extract extractum.
8. a kind of Herba Dendrobii compound preparation as claimed in claim 2, is characterized in that: described powder refers to that medicine is through being crushed to micropowders more than 300 orders.
9. the preparation method of the compound preparation described in claim 1 or 2 or 3, is characterized in that the method comprises the steps:
Herba Dendrobii, Rhizoma Gastrodiae, Semen Platycladi, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Fructus Lycii are made a call to 100 order powder, water or organic solvent extraction obtain pharmaceutical composition extractum, add again the agent of pharmaceutically acceptable carrier granulation, granule is packed into and in capsulae vacuus, obtains capsule, granule is pressed into sheet and obtains tablet, tablet carries out film coating outward and obtains coated tablet; Pharmaceutical composition extract extractum adds diluent standardize solution to obtain tincture and oral liquid; 70% ethanol sterilizing for pharmaceutical composition, carries out micronizing and obtains powder.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606510A (en) * | 2014-12-31 | 2015-05-13 | 浙江济公缘药业有限公司 | Dendrobium candidum compound preparation for treating tumor related sleep disorder |
| CN105920186A (en) * | 2016-06-07 | 2016-09-07 | 华南师范大学 | Traditional Chinese medicine for treating haemorrhoids and preparation method thereof |
| CN106360716A (en) * | 2016-08-22 | 2017-02-01 | 蓬莱海洋（山东）股份有限公司 | Traditional Chinese medicinal composition for improving body immunity and sleep, and preparation method thereof |
| CN113181205A (en) * | 2021-04-19 | 2021-07-30 | 苏州人本药业有限公司 | Pharmaceutical compositions comprising NMN and uses thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178849A (en) * | 2010-07-20 | 2011-09-14 | 朱友文 | Chinese medicine preparation for treating insomnia and preparation method thereof |
| CN103843952A (en) * | 2014-01-15 | 2014-06-11 | 云南云尚生物技术有限公司 | Processing method of dendrobium officinale leaf tea |
-
2014
- 2014-08-27 CN CN201410427449.6A patent/CN104147394B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178849A (en) * | 2010-07-20 | 2011-09-14 | 朱友文 | Chinese medicine preparation for treating insomnia and preparation method thereof |
| CN103843952A (en) * | 2014-01-15 | 2014-06-11 | 云南云尚生物技术有限公司 | Processing method of dendrobium officinale leaf tea |
Non-Patent Citations (1)
| Title |
|---|
| 陈小明: "二仁二子汤治疗顽固性失眠127例", 《实用中医药杂志》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606510A (en) * | 2014-12-31 | 2015-05-13 | 浙江济公缘药业有限公司 | Dendrobium candidum compound preparation for treating tumor related sleep disorder |
| CN104606510B (en) * | 2014-12-31 | 2017-09-15 | 浙江济公缘药业有限公司 | Dendrobium candidum compound preparation for treating cancer-related sleep-disorder |
| CN105920186A (en) * | 2016-06-07 | 2016-09-07 | 华南师范大学 | Traditional Chinese medicine for treating haemorrhoids and preparation method thereof |
| CN105920186B (en) * | 2016-06-07 | 2019-12-31 | 华南师范大学 | A Chinese medicinal composition for treating hemorrhoid, and its preparation method |
| CN106360716A (en) * | 2016-08-22 | 2017-02-01 | 蓬莱海洋（山东）股份有限公司 | Traditional Chinese medicinal composition for improving body immunity and sleep, and preparation method thereof |
| CN113181205A (en) * | 2021-04-19 | 2021-07-30 | 苏州人本药业有限公司 | Pharmaceutical compositions comprising NMN and uses thereof |
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| CN104147394B (en) | 2017-12-01 |
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