CN102358903B - 作为选择性ngf途径抑制剂的人抗ngf中和抗体 - Google Patents
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Abstract
Description
原始氨基酸 | 示例性置换 | 优选置换 |
Ala | Val,Leu,Ile | Val |
Arg | Lys,Gln,Asn | Lys |
Ash | Gln | Gln |
Asp | Glu | Glu |
Cys | Ser,Ala | Ser |
Gln | Asn | Asn |
Glu | Asp | Asp |
Gly | Pro,Ala | Ala |
His | Asn,Gln,Lys,Arg | Arg |
Ile | Leu,Val,Met,Ala,Phe,正亮氨酸 | Leu |
Leu | 正亮氨酸,Ile,Val,Met,Ala,Phe | Ile |
Lys | Arg,1,4二氨基丁酸,Gln,Asn | Arg |
Met | Leu,Phe,Ile | Leu |
Phe | Leu,Val,Ile,Ala,Tyr | Leu |
Pro | Ala | Gly |
Ser | Thr,Ala,Cys | Thr |
Thr | Ser | Ser |
Trp | Tyr,Phe | Tyr |
Tyr | Trp,Phe,Thr,Ser | Phe |
Val | Ile,Met,Leu,Phe,Ala,正亮氨酸 | Leu |
Ab | IC50@hNGF(nM) | IC50@rNGF(nM) |
4D4.IgG1.R | 0.1488 | >34nM |
4D4.IgG1.S | 0.1587 | >45nM |
4D4.IgG2.R | 0.2047 | >59nM |
4D4.IgG2.S | 0.2063 | >37nM |
肽# | 序列 | SEQ ID NO |
33582-27-01 | SSSHPIFHRGEFSVC(1-15) | 56 |
33582-27-02 | IFHRGEF SVADSVSVC(6-20) | 57 |
33582-27-03 | EFSVADSVSVWVGDKC(11-25) | 58 |
33582-27-04 | DSVSVWVGDKTTATDC(16-30) | 59 |
33582-27-05 | WVGDKTTATDIKGKEC(21-35) | 60 |
33582-27-06 | TTATDIKGKEVMVLGC(26-40) | 61 |
33582-27-07 | IKGKEVMVLGEVNIN (31-45) | 62 |
33582-27-08 | VMVLGEVNINNSVFKC(36-50) | 63 |
33582-27-09 | EVNINNSVFKQYFFEC(41-55) | 64 |
33582-27-10 | NSVFKQYFFETKARDC(46-60) | 65 |
33582-27-11 | QYFFETKARDPNPVDC(51-65) | 66 |
33582-27-12 | TKARDPNPVDSGARDC(56-70) | 67 |
33582-27-13 | PNPVDSGARDIDSKHC(61-75) | 68 |
33582-27-14 | SGARDIDSKHWNSYC(66-80) | 69 |
33582-27-15 | IDSKHWNSYATTTHTC(71-85) | 70 |
33582-27-16 | WNSYATTTHTFVKALC(76-90) | 71 |
33582-27-17 | TTTHTFVKALTMDGKC(81-95) | 72 |
33582-27-18 | FVKALTMDGKQAAWRC(86-100) | 73 |
33582-27-19 | TMDGKQAAWRFIRIDC(91-105) | 74 |
33582-27-20 | QAAWRFIRIDTAAVC(96-110) | 75 |
33582-27-21 | FIRIDTAAVAVLSRKC(101-115) | 76 |
33582-27-22 | TAAVAVLSRKAVRRAC(106-120) | 77 |
33582-27-23 | CAAVAVLSRKAVRRA(107-120) | 78 |
4D4VH | 14D10VH | 6H9VH | 7H2VH | 14D11VH | 4G6VH | |
4D4VH | 100% | 70.9% | 70.1% | 75.6% | 47.2% | 73.4% |
14D10VH | 100% | 95.3% | 85% | 54.3% | 81.1% | |
6H9VH | 100% | 86.6% | 54.3% | 81.1% | ||
7H2VH | 100% | 51.2% | 79.8% | |||
14D11VH | 100% | 56.8% | ||||
4G6VH | 100% |
Claims (18)
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US48743103P | 2003-07-15 | 2003-07-15 | |
US60/487431 | 2003-07-15 | ||
CN2004800262422A CN1849138B (zh) | 2003-07-15 | 2004-07-15 | 作为选择性ngf途径抑制剂的人抗ngf中和抗体 |
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CN2004800262422A Expired - Fee Related CN1849138B (zh) | 2003-07-15 | 2004-07-15 | 作为选择性ngf途径抑制剂的人抗ngf中和抗体 |
CN201110291428.2A Expired - Fee Related CN102408483B (zh) | 2003-07-15 | 2004-07-15 | 作为选择性ngf途径抑制剂的人抗ngf中和抗体 |
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CN201110291428.2A Expired - Fee Related CN102408483B (zh) | 2003-07-15 | 2004-07-15 | 作为选择性ngf途径抑制剂的人抗ngf中和抗体 |
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EP (2) | EP2364728A1 (zh) |
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