CN102078522A - Chinese medicine composition for treating enterovirus syndrome in chicken - Google Patents
Chinese medicine composition for treating enterovirus syndrome in chicken Download PDFInfo
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Abstract
The invention relates to a Chinese medicine composition for treating enterovirus syndrome in chicken, which mainly comprises ten kinds of Chinese herbal medicines, such as sweet wormwood, antipyretic dichroa, Chinese pulsatilla root, lightyellow sophora root, golden cypress and the like. The Chinese medicine composition has the actions of killing inspects, sterilizing and benefiting qi and enriching blood and has an obvious effect on the enterovirus syndrome caused by coccidium and bacterial infections. The Chinese medicine composition has the advantages of easiness of acquirement of medicinal materials and convenient preparation process and is suitable for industrial production.
Description
Technical field
The invention belongs to the herbal medicine technical field, relate in particular to a kind of Chinese medicine composition that is used for the treatment of the Intestinum Gallus domesticus toxicity syndrome and preparation method thereof.
Background technology
Broiler is cultured market survey and found: commercial meat bird is raised flourishing area, ubiquity a kind of with contain feedstuff, the poor growth that digestion is good in diarrhoea, the feces or lose weight, disease that dehydration and the price of deed drop to feature.This disease is generally popular, though mortality rate is not high, the recessive economic loss that causes is huge, often causes the general dyspepsia of thinking of raiser's mistake, or thought single small intestinal coccidium infection by the veterinary clinic worker, in fact it is the syndrome that is caused by Different types of etiopathogenises.This disease is called " intestinal poison " in feeding of broiler developed regions, Shandong by the raiser, Hebei and feeding of broiler developed regions, Liaoning claim " punishment in advance ", and a lot of professors expert name this disease and are " intestinal toxicity syndrome ".
One, clinical symptoms and pathological change
1, clinical symptoms: their early stage, the chicken group does not generally have tangible symptom, and spirit is normal, and appetite is normal, and mortality rate is also in normal range.Indivedual chicken manures are just thinning, shapeless, contain indigested feedstuff in the excrement, prolongation along with the time, most of chicken of whole chicken group begins diarrhoea, and the chicken mass-sending unboiled water that has rushes down, and it is thinner that feces becomes, shapeless, not in heaps, bigger than normal chicken manure area occupied, more indigested corn grit and bean cypress crushed grain are arranged in the feces, and the color of feces shoals, and shows slightly light yellow or shallow yellow green.After this kind feces appears in most chickens among the chicken group about 2-3 days, chicken group's feed intake began obvious decline, generally descends about 10～20%, and the chicken that the has appetite of mining massively can descend more than 30%, at this moment, if can not get correct treatment, can cause massive losses.These sick intermediary and later stages, neural excitation, crazy race can appear in indivedual chickens, weak and limp afterwards death.
2, pathological change: the part intestinal mucosa before the their early stage, the yolk stalk of duodenum, jejunum thickens, and color shoals, and is canescence, like a Ceng Hou Hou De Fu skin, very easily peels off; Intestinal wall also thickens, acoprosis, content is less, the time and see some indigested feedstuffs.Serious saffron Fructus Kaki sample, fish intestinal sample or the Radix Dauci Sativae sample material of being full of in the small intestinal posterior segment.The middle and late stage of morbidity, the intestinal wall attenuation, intestinal mucosa also comes off, and the enteral thing is Ovum Gallus domesticus album sample, sticking pus sample or Fructus Kaki sample, and idol has that stomach is swollen, proventriculitis.And see that liver is hemorrhage, cecal tonsil swelling is hemorrhage, fabricius bursa atrophy, renal swelling etc.Other internal organs do not have obvious pathological changes.
Two, epidemic characteristic
Intestinal toxicity syndrome in Shandong, Hebei, Liaoning, Jiangsu, Henan etc. economize the area of feeding of broiler prosperity, are that ground flat is supported or online flat commercial meat bird of supporting ubiquity all.
1, be the season occurred frequently of primary disease the end of month mid-June to 9.
2, this sick sending out in the broiler of 30～40 ages in days, other age in days also can take place, but degree is lighter, and the negligible amounts of morbidity can betide the 7--10 age in days the earliest, and in general, the broiler that ground flat is supported is fallen ill earlier, and online flat broiler morbidity of supporting is a little later.
3, easy and coccidiosis while or generation successively of primary disease.
4, density is excessive, and humidity is excessive, improper ventilation, and the chicken group pilosity of sanitary condition difference, symptom is also more serious, and therapeutic effect is relatively poor.
5, the feed high-quality feed of comprehensive nutritions such as containing high quality protein, energy, vitamin, the chance that " intestinal poison syndrome " takes place is just big more, and symptom is also more serious.In contrast, the chance that the feedstuff that quality is lower takes place is few, and symptom is also light.We find also that in investigation this disease takes place by more serious chicken group, and the sickness rate of sudden death disease obviously rises, weak and limp, the depleted dead chicken showed increased in excited earlier uneasiness back.
Three, pathogenic factor
1, the infection of the infection small intestinal coccidiosis of small intestinal coccidiosis is the one of the main reasons of primary disease.Small intestinal coccidiosis main parasitic is in intestinal epithelial cell, when its raised growth breeding, must cause intestinal mucosa to thicken, edema, pathological changes such as seriously come off and hemorrhage, feedstuff can not be absorbed by catapepsis, absorption to moisture simultaneously also obviously reduces, although the chicken great quantity of water drinking also can cause the dehydration phenomenon, so the feces that morbidity chicken group is arranged is just very thin and shapeless, contains the feedstuff that is not digested.
2, bacterial infection: antibacterial can cause enteritis, also be one of cause of disease of enterotoxic syndrome of meat chicken: as Salmonella, aerogenesis folder film clostridium etc., destroy intestinal mucosa by stimulating, cause inflammation, enterokinesia is speeded up, Digestive system hypereccrisia, feed link are crossed gastral time shortening, cause dyspepsia.
3, viral infection: virus also is one of inducement that causes intestinal toxicity syndrome; Cause enteritis as arc reovirus virus, the absorption function of infringement intestinal.
4, the acid base imbalance in the intestinal: owing to reasons such as season, feedstuff, pathogenic microorganism cause alteration of intestinal flora, produce a large amount of lactic acid, the interior pH value of intestinal is seriously reduced, intestinal environment changes, probiotics reduces, and harmful bacterium breeds in a large number, and meanwhile intestinal is in anaerobic environment, anaerobe such as clostridieum welchii, clostridium perfringens enterotoxin can be bred in a large number, thereby harmful bacterium and coccidiosis coordinate to have strengthened pathogenic mutually.Will cause probiotics to reduce like this, and harmful bacterium raised growth breeding, particularly the breeding of the raised growth of escherichia coli, Salmonella has increased the weight of pathogenic.The secreted toxin of flora increases, and stimulates intestinal mucosa that enterokinesia is accelerated, and Digestive system is discharged and increased, the time that feed link is crossed intestinal shortens, dyspepsia, indigested feedstuff excretes together in company with the mucosa that comes off, and forms distinctive Fructus Lycopersici esculenti sample or fish intestinal sample feces.
5, electrolyte runs off in a large number: because coccidiosis and the breeding of harmful bacterium raised growth cause dyspepsia and intestinal absorption obstacle, electrolyte absorption is reduced, simultaneously, the disintegrate because a large amount of intestinal mucosa cells breaks rapidly, electrolyte is run off in a large number, a large amount of losses of Physiology and biochemistry obstacle, particularly potassium ion occur, can cause the hyperexcitability of heart to strengthen, this also is the one of the main reasons of sudden death disease of meat chicken showed increased.
6, self poisoning: in the process of morbidity, a large amount of intestinal epithelial cells break, under the effect of antibacterial, take place corrupt the decomposition, the intestinal mucosa that comes off simultaneously, the dead decomposition of fermenting in vivo such as polypide produce a large amount of noxious substances, self poisoning all can be taken place by body absorption back in the unusual excretory toxin of flora in the intestinal, excited uneasiness occurs, screams, paralyses and symptoms such as depleted death.
7, feedstuff factor: lot of energy, protein and part vitamin can promote a large amount of breedings of antibacterial and coccidiosis in the feedstuff, increase the weight of symptom.So nutrition is abundant more, sickness rate is just high more, and symptom is just serious more.And the lower feedstuff relative incidence of the quality of feeding is lower.The feedstuff that goes mouldy in addition also can increase the weight of the state of an illness.
8, drug intoxication: long-term prescription, make medicine cause damage to intestinal mucosa, cause enteritis.
Four, prophylactico-therapeutic measures
1, strengthen feeding and management, duty is changed bedding and padding, lowers stocking density, reduces the stimulation of various stressors and prevents the generation of complication.
2, keep sanitation and hygiene, particularly feed trough, the water fountain of hen house regularly to sterilize.Keep well-ventilated in the hen house, air is fresh.Intensity of illumination, time, temperature, humidity should meet the specification requirement of scientific management.
3, feedstuff: ban use of the feedstuff that goes mouldy.The interpolation forage protein and the vitamin of science.
4, rationally use chemoprophylaxis, give an amount of vitamin, help the growth promoter of chickling, strengthen premunition.
Summary of the invention
For these reasons, the invention provides a kind of Chinese medicine composition for the treatment of the Intestinum Gallus domesticus toxicity syndrome.
1, an object of the present invention is to provide a kind of Chinese medicine composition for the treatment of the Intestinum Gallus domesticus toxicity syndrome, it is characterized in that described Chinese medicine composition is made up of following component: Herba Artemisiae Annuae, Radix Dichroae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Cortex Phellodendri, Cortex Fraxini, Rhizoma Coptidis, Rhizoma Imperatae, the Radix Astragali, Radix Glycyrrhizae.
2, the parts by weight of above-mentioned Chinese medicine composition each component are: Herba Artemisiae Annuae 6-18 part, Radix Dichroae 6-18 part, Radix Pulsatillae 6-18 part, Radix Sophorae Flavescentis 5-15 part, Cortex Phellodendri 5-15 part, Cortex Fraxini 5-15 part, Rhizoma Coptidis 2-8 part, Rhizoma Imperatae 2-8 part, Radix Astragali 2-8 part, Radix Glycyrrhizae 2-8 part.
3, above-mentioned Chinese medicine composition each component parts by weight are preferred: 12 parts of Herba Artemisiae Annuaes, 12 parts of Radix Dichroaes, 12 parts of the Radix Pulsatillaes, 10 parts of Radix Sophorae Flavescentiss, 10 parts of Cortex Phellodendris, 10 parts of Cortex Fraxinis, 5 parts of Rhizoma Coptidis, 5 parts of Rhizoma Imperataes, 5 parts of the Radixs Astragali, 5 parts in Radix Glycyrrhizae.
4, above-mentioned Chinese medicine composition can be made powder, granule, oral solution according to culturing needs, uses for chicken drinking-water or spice.
The Radix Pulsatillae, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini, Radix Sophorae Flavescentis have heat clearing and damp drying in this Chinese medicine composition, the effect of eliminating pathogenic heat from blood to cure dysentery; The Radix Dichroae heat clearing and damp drying, parasite killing, expectorant removing food stagnancy; Herba Artemisiae Annuae, Rhizoma Imperatae heat-clearing and toxic substances removing, cooling blood for hemostasis; The Radix Astragali, Radix Glycyrrhizae invigorating qi and benefiting blood, coordinating the actions of various ingredients in a prescription; All medicines share, and have the effect of parasite killing, sterilization, vigorate qi and replenish the blood, and are remarkable to the intestinal toxicity syndrome effect that causes because of coccidiosis, bacterial infection.
The invention has the beneficial effects as follows:
1, raw material uses generally, is easy to obtain;
2, spice, drinking-water all can, easy to use;
3, can be prepared into powder, granule, oral solution, industrial preparation process is simple.
The specific embodiment
Can observe beneficial effect of the present invention with the following Examples, these embodiment are illustrative, can not be construed as limiting the present invention.
The preparation of embodiment 1, present composition powder:
Prescription:
Compound method:
1, weighing, clean: take by weighing the medical material of respectively distinguishing the flavor of by recipe quantity, the impurity of sneaking in the medical material is removed, the medical material that selection is good is put respectively in the clean container.
2, the above-mentioned medical material that cleans adds respectively in the pulverizer, and it is standby to cross 24 mesh sieves.
3, above-mentioned ten Chinese medicines of distinguishing the flavor of and crushing are behind the proportionally abundant mixing, all by 24 mesh sieves, promptly.
The preparation of embodiment 2, present composition granule:
Prescription:
Compound method:
1, weighing, clean: weigh up medical material by recipe quantity, the impurity of sneaking in the medical material is removed, the medical material that selection is good is put in the clean container.
2, the above-mentioned medical material of handling well decocts with water secondary, and each 2 hours, collecting decoction filtered, and filtrate is concentrated into the thick paste that relative density is 1.29～1.31 (80 ℃).
3, get above-mentioned thick paste, with sucrose, dextrin (ratio is 4: 1) in right amount, mixing, granulation, dry, granulate are made 6kg promptly.
The preparation of embodiment 3, present composition oral solution:
Prescription:
1, weighing, clean: weigh up medical material by recipe quantity, the impurity of sneaking in the medical material is removed, the medical material that selection is good is put in the clean container.
2, the above-mentioned medical material that cleans add purified water moistening after, add 6～8 times of purified water, decoct secondary, each 2 hours.Filter, merging filtrate is concentrated into about 3000ml, adds 2～3 times of amount 95% ethanol, fully stirs, and places more than 12 hours, filter, disgorging reclaims ethanol, adds ethanol 2～3 times till do not have a precipitation by last method, put refrigerator cold-storage more than 24 hours, filter, reclaim ethanol, standby.
3, above-mentioned solution is settled to 6000ml with purified water, stirs evenly, filter, and embedding, sterilization, promptly.
Embodiment 4, the present composition are to the effect test of intestinal toxicity syndrome:
(1) experimental animal
The Tianjin chicken house has a collection of 20 aa broiler chicken, during 15 ages in days, finds the feces punishment in advance, and the chicken appetite of mining massively is low, and standing, it is listless to beat.Cut open visible glandular stomach swelling of inspection such as ball, turn white.Be diagnosed as proventriculitis.Effect is undesirable after composite B vitamin, ampicillin administration, prolongation along with the time, most of chicken of whole chicken group begins diarrhoea, the chicken mass-sending unboiled water that has rushes down, feces thins out, and is shapeless, not in heaps, bigger than normal chicken manure area occupied, and more indigested corn grit and bean cypress crushed grain are arranged in the feces, the color of feces shoals, and shows slightly light yellow or shallow yellow green.Chicken group's feed intake obviously descends.Merge intestinal infection, intestinal toxicity syndrome for the chicken proventriculitis after diagnosing.
(2) EXPERIMENTAL DESIGN and method
Select 300 of the sick chickens of this chicken house at random, select the powder of medicine embodiment one preparation of the present invention for use, test.Testing one group is low dose group (mixed feeding, every 1kg feedstuff, this product 1g), free choice feeding, logotype three days; Testing two groups is middle dosage group (mixed feeding, every 1kg feedstuff, this product 2g), free choice feeding, logotype three days; Testing three groups is high dose group (mixed feeding, every 1kg feedstuff, this product 4g) free choice feeding, logotype three days; Testing four groups is the routine administration group, selects commercially available norfloxacin nicotinate soluble powder (specification 5%) for use, mixes drink, every 1L water, 0.5g, logotype three days.
(3) curative effect determinate standard
Cure rate: spirit, appetite, clinical symptoms are recovered normal sick chicken fully and are accounted for the ratio that this organizes total chicken number after the off-test.
Effective percentage: the sick chicken that spirit, appetite, clinical symptoms are clearly better after the off-test accounts for the ratio that this organizes total chicken number.
Inefficiency: duration of test occurs dead, and the sick chicken of not feeling any better after the medication accounts for the ratio that this organizes total chicken number.
Table 1 medicine of the present invention is to Intestinum Gallus domesticus toxicity syndrome control test grouping
(4) result of the test
Medicine of the present invention is to the therapeutic effect of Intestinum Gallus domesticus toxicity syndrome.
Table 2 clinical test results
Chinese medicine composition of the present invention as can be seen from the above table can effectively be prevented and treated chicken proventriculitis concurrent infection intestinal toxicity syndrome.Dosage group effect is better in selecting for use.The Radix Pulsatillae, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini, Radix Sophorae Flavescentis have heat clearing and damp drying in this Chinese medicine composition, the eliminating pathogenic heat from blood to cure dysentery function; The Radix Dichroae heat clearing and damp drying, parasite killing, expectorant removing food stagnancy; Herba Artemisiae Annuae, Rhizoma Imperatae heat-clearing and toxic substances removing, cooling blood for hemostasis; The Radix Astragali, Radix Glycyrrhizae invigorating qi and benefiting blood coordinating the actions of various ingredients in a prescription; All medicines share, and have the effect of parasite killing, sterilization, vigorate qi and replenish the blood, and are remarkable to the intestinal toxicity syndrome effect that causes because of coccidiosis, bacterial infection.
Claims (4)
1. Chinese medicine composition that is used for the treatment of the Intestinum Gallus domesticus toxicity syndrome is characterized in that described Chinese medicine composition is made up of following component: Herba Artemisiae Annuae, Radix Dichroae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Cortex Phellodendri, Cortex Fraxini, Rhizoma Coptidis, Rhizoma Imperatae, the Radix Astragali, Radix Glycyrrhizae.
2. a kind of Chinese medicine composition that is used for the treatment of the Intestinum Gallus domesticus toxicity syndrome according to claim 1 is characterized in that the parts by weight of described Chinese medicine composition each component are: Herba Artemisiae Annuae 6-18 part, Radix Dichroae 6-18 part, Radix Pulsatillae 6-18 part, Radix Sophorae Flavescentis 5-15 part, Cortex Phellodendri 5-15 part, Cortex Fraxini 5-15 part, Rhizoma Coptidis 2-8 part, Rhizoma Imperatae 2-8 part, Radix Astragali 2-8 part, Radix Glycyrrhizae 2-8 part.
3. a kind of Chinese medicine composition that is used for the treatment of the Intestinum Gallus domesticus toxicity syndrome according to claim 1 is characterized in that described Chinese medicine composition each component parts by weight are preferred: 12 parts of Herba Artemisiae Annuaes, 12 parts of Radix Dichroaes, 12 parts of the Radix Pulsatillaes, 10 parts of Radix Sophorae Flavescentiss, 10 parts of Cortex Phellodendris, 10 parts of Cortex Fraxinis, 5 parts of Rhizoma Coptidis, 5 parts of Rhizoma Imperataes, 5 parts of the Radixs Astragali, 5 parts in Radix Glycyrrhizae.
4. a kind of Chinese medicine composition that is used for the treatment of the Intestinum Gallus domesticus toxicity syndrome according to claim 1 is characterized in that described Chinese medicine composition can make powder, granule, oral solution according to culturing needs, for chicken drinking-water or spice use.
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Cited By (9)
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| CN102266502A (en) * | 2011-07-25 | 2011-12-07 | 鼎正动物药业（天津）有限公司 | Traditional Chinese medicine granules for treating coccidiosis of livestock and poultry, and preparation method thereof |
| CN102716213A (en) * | 2012-06-06 | 2012-10-10 | 四川金瑞克动物药业有限公司 | Coptis and radix sophorae flavescentis anti-dysenteric particle as well as preparation method and application of coptis and radix sophorae flavescentis anti-dysenteric particle |
| CN103083427A (en) * | 2011-10-27 | 2013-05-08 | 天津生机集团股份有限公司 | Traditional Chinese medicine powder used for preventing and treating layer enterovirus syndrome |
| CN104055891A (en) * | 2014-07-01 | 2014-09-24 | 施瑞客（天津）生物技术有限公司 | Coccidiosis control traditional Chinese medicine composition for rabbits and preparation method thereof |
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| CN104940637A (en) * | 2015-07-25 | 2015-09-30 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medicine composition for treating clostridium welchii disease of foxes and preparation method thereof |
| CN109364230A (en) * | 2018-12-18 | 2019-02-22 | 丹东瑞丰动物药业有限责任公司 | A kind of Chinese medicine and preparation method thereof for treating chicken coccidiasis |
| CN109394881A (en) * | 2018-11-29 | 2019-03-01 | 广东高山动物药业有限公司 | Prevent and treat pure Chinese medicine composition of poultry enterotoxin syndrome and preparation method thereof and application method |
| CN114796403A (en) * | 2022-05-31 | 2022-07-29 | 杨建彬 | Intestine-invigorating powder and application thereof |
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| CN102266502A (en) * | 2011-07-25 | 2011-12-07 | 鼎正动物药业（天津）有限公司 | Traditional Chinese medicine granules for treating coccidiosis of livestock and poultry, and preparation method thereof |
| CN103083427A (en) * | 2011-10-27 | 2013-05-08 | 天津生机集团股份有限公司 | Traditional Chinese medicine powder used for preventing and treating layer enterovirus syndrome |
| CN103083427B (en) * | 2011-10-27 | 2016-08-03 | 天津生机集团股份有限公司 | A kind of Chinese powder medicine for preventing and treating laying hen intestinal toxicity syndrome |
| CN102716213A (en) * | 2012-06-06 | 2012-10-10 | 四川金瑞克动物药业有限公司 | Coptis and radix sophorae flavescentis anti-dysenteric particle as well as preparation method and application of coptis and radix sophorae flavescentis anti-dysenteric particle |
| CN104055891A (en) * | 2014-07-01 | 2014-09-24 | 施瑞客（天津）生物技术有限公司 | Coccidiosis control traditional Chinese medicine composition for rabbits and preparation method thereof |
| CN104055891B (en) * | 2014-07-01 | 2016-08-24 | 施瑞客（天津）生物技术有限公司 | A kind of rabbit Chinese medicine composition preventing and treating global-worm illness and preparation method thereof |
| CN104491106A (en) * | 2014-12-01 | 2015-04-08 | 登封市博爱农林牧开发有限公司 | Traditional Chinese medicinal preparation for preventing and treating clostridiosis of sheep |
| CN104940637A (en) * | 2015-07-25 | 2015-09-30 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medicine composition for treating clostridium welchii disease of foxes and preparation method thereof |
| CN109394881A (en) * | 2018-11-29 | 2019-03-01 | 广东高山动物药业有限公司 | Prevent and treat pure Chinese medicine composition of poultry enterotoxin syndrome and preparation method thereof and application method |
| CN109364230A (en) * | 2018-12-18 | 2019-02-22 | 丹东瑞丰动物药业有限责任公司 | A kind of Chinese medicine and preparation method thereof for treating chicken coccidiasis |
| CN114796403A (en) * | 2022-05-31 | 2022-07-29 | 杨建彬 | Intestine-invigorating powder and application thereof |
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Application publication date: 20110601 |