CN104940637A - Traditional Chinese medicine composition for treating clostridium welchii disease of foxes and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating clostridium welchii disease of foxes and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating clostridium welchii disease of foxes. The traditional Chinese medicine composition is prepared from 16-30 parts of Chinese pulsatilla root, 12-15 parts of ash bark, 15-20 parts of coptis chinensis, 10-15 parts of semen plantaginis, 15-25 parts of bletilla striata and 10-18 parts of medicine terminalia fruit. The traditional Chinese medicine composition can be powder and is prepared through the following steps: (1), weighing all traditional Chinese medicines according to the formula ratio; (2) smashing all traditional Chinese medicines and screening through a 40-80-mesh sieve; (3), mixing for 10-15 minutes to obtain traditional Chinese medicine powder; (4), sub-packaging the traditional Chinese medicine powder, so as to obtain the finished product, wherein each bag is filled with 100-200 g of the traditional Chinese medicine powder. The traditional Chinese medicine composition has the efficacy of clearing heat, eliminating dampness, cooling blood, stopping dysentery, converging and stopping bleeding. The traditional Chinese medicine composition provided by the invention has an exact curative effect on treating clostridium welchii disease of foxes and the cure rate can reach 84.8%.
Description
Technical field
The invention belongs to Chinese veterinary drug preparation field, be especially a kind ofly used for the treatment of Chinese medicine composition of fox clostridieum welchii disease and preparation method thereof.
Background technology
Fox clostridieum welchii disease, also known as clostridieum welchii enteritis, is the dysentery disease caused by A type clostridieum welchii and toxin thereof.Clinical symptoms is acute dysentery, and row's dark viscous feces, pathological characters shows as gastric mucosa has black ulcer and caecum serosal surface to have the ecchymosis of sesame seed size.A type clostridieum welchii is prevalent in the intestinal of soil, feces, sewage, feedstuff and healthy animal, morbidity and dead animal corpse be also propagate primary disease source of disease ground.Because eating the feedstuff of pollution, feeding and management is improper, feedstuff is changed suddenly, protein feeds is excessive, and crude fibre is too low, gastrointestinal normal flora is lacked of proper care, A type clostridieum welchii in intestinal can be caused to breed rapidly, produces toxin, causes enterotoxemia and dysentery death.Sick Vulpes searches for food minimizings as seen, passage of loose stools, and sick is just after lark be celadon, is finally coal tar oil colours shape.Spirit is poor, rolls up in cage motionless.Abdominal distension, has ascites.Urine color is secretly in tea color.If do not treated, dead in 2 ~ 3 days after morbidity, individual other can delay about 1 week, but final dead because of intestinal absorption toxin.Corpse outward appearance is without obviously becoming thin.Open abdominal cavity and have special rotten odor, gastrointestinal endogenous cause of ill gassy and expanding, cut coat of the stomach, gastric mucosa has several black ulcer surface differed in size.Visible circular ecchymosis on caecum inflation, expansion, serosal surface and part mesentery.The sticky shape feces of black of corrupt abnormal smells from the patient is filled with in each intestinal segment of small intestinal.Primary disease all can occur throughout the year, and occur autumn comparatively serious, sickness rate 10% ~ 30%, case fatality rate 90% ~ 100%, brings huge economic loss to fox aquaculture.
Current primary disease mainly adopts antibiotic therapy, as intramuscular injection gentamycin or baytril, has certain curative effect in early days to morbidity, is difficult to cure to severe cases.And antibiotic therapy very easily produces drug resistance.Therefore be badly in need of a kind of Chinese medicine composition of exploitation, can effectively treat fox clostridieum welchii disease, reduce economic loss.
Summary of the invention
The problem to be solved in the present invention is: overcome the deficiencies in the prior art, provides a kind of evident in efficacy, cure rate is high, side effect is low Chinese medicine composition.
Another technical problem that the present invention will solve is: provide a kind of Chinese medicine formula for the treatment of fox clostridieum welchii disease.
Another technical problem that the present invention will solve is: the preparation method providing the powder of above-mentioned Chinese medicine composition.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of Chinese medicine composition being used for the treatment of fox clostridieum welchii disease, is characterized in that: be prepared from by the raw material of following mass fraction: Radix Pulsatillae 16-30 part, Cortex Fraxini 12-15 part, Rhizoma Coptidis 15-20 part, Semen Plantaginis 10-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-25 part, Fructus Chebulae 10-18 part.
Further, the mass fraction of the optimum feed stock of this Chinese medicine composition is as follows: the Radix Pulsatillae 30 parts, Cortex Fraxini 12 parts, Rhizoma Coptidis 18 parts, Semen Plantaginis 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20 parts, Fructus Chebulae 10 parts.
Further, this Chinese medicine composition is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
Further, described preparation can be powder.
Further, the preparation method of the powder of said composition is: (1) takes each Chinese medicine by formula ratio; (2) Chinese medicine is pulverized, cross 40-80 mesh sieve; (3) mix 10-15 minute and obtain Chinese medicine powder; (4) Chinese medicine powder is pressed every bag of 100-200g subpackage, get product.
The advantage that the present invention has and good effect are:
(1) this prescription is according to tcm theory, and scientific compatibility, has effect of heat clearing and damp drying, eliminating pathogenic heat from blood to cure dysentery, relieving diarrhea with astringents, astringing to arrest bleeding.Through Clinical Laboratory determined curative effect, cure rate can reach 84.8%.
(2) Chinese powder medicine obtained according to this prescription has the advantage that technique is simple, evident in efficacy, side effect is low.
(3) pharmacological action of each raw material of Chinese medicine of the present invention is:
The Radix Pulsatillae: heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery;
Cortex Fraxini: heat clearing and damp drying, astringent therapy dysentery relieving, improving eyesight;
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication;
Semen Plantaginis: inducing diuresis for treating stranguria syndrome, eliminating dampness by diuresis antidiarrheal, improving eyesight, eliminates the phlegm;
The Pseudobulbus Bletillae (Rhizoma Bletillae): astringing to arrest bleeding, detumescence and promoting granulation;
Fructus Chebulae: relieving diarrhea with astringents, astringing lung-QI and relieving cough, relieving sore throat to recover voice.
Among formula, Radix Pulsatillae bitter cold is fallen and is let out, heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, is especially good at the damp and hot and noxious heat in the blood system of clearing stomach intestinal, therefore for controlling the good medicine of toxic-heat and blood stasis.Cortex Fraxini bitter cold and astringent therapy, function heat clearing and damp drying, astringent therapy dysentery relieving, leukorrhagia stopping.Rhizoma Coptidis large bitter Great Cold, kindly go taste damp-heat in the large intestine, for controlling dysentery key medicine.Rhizoma Coptidis and extract component thereof have antiulcer action in addition.Radix Pulsatillae compatibility Rhizoma Coptidis, the same use of Cortex Fraxini, can control damp-heat dysentery, tenesmus, the card of dysentery pus and blood.Semen Plantaginis is sweet cold and sharp, can wet by diuretic, divides pure and impure and antidiarrheal, i.e. treating diarrhea by diuretics.Pseudobulbus Bletillae (Rhizoma Bletillae) matter glues puckery, is the key medicine of astringing to arrest bleeding, available control inside and outside all go out blood disorder, control all internal hemorrhages card, can grind into powder and take by single.Chebulinic acid adstringency is received, and enters large intestine, kind energy relieving diarrhea with astringents, is the common drug for the treatment of chronic diarrhea, chronic dysentery.The property that Fructus Chebulae is sour and astringent in addition, again can relieving diarrhea with astringent, and astringing intestine to stop diarrhea stops blooding.Above-mentioned Six-element medicine compatibility uses, and has effect of heat clearing and damp drying, eliminating pathogenic heat from blood to cure dysentery, relieving diarrhea with astringents, astringing to arrest bleeding, effectively can treat all symptoms of fox clostridieum welchii disease.
Detailed description of the invention
Be further described the present invention below by specific embodiment, following examples are descriptive, are not determinate, can not limit protection scope of the present invention with this.
Embodiment 1
Be used for the treatment of a Chinese powder medicine for fox clostridieum welchii disease, the parts by weight of each raw material are as follows: the Radix Pulsatillae 30 parts, Cortex Fraxini 12 parts, Rhizoma Coptidis 18 parts, Semen Plantaginis 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20 parts, Fructus Chebulae 10 parts are prepared from.Its preparation method is: (1) takes each Chinese medicine by formula ratio; (2) Chinese medicine is pulverized, cross 60 mesh sieves; (3) mix 15 minutes and obtain Chinese medicine powder; (4) Chinese medicine powder is pressed every bag of 100g subpackage, get product.
Embodiment 2
Be used for the treatment of a Chinese powder medicine for fox clostridieum welchii disease, the parts by weight of each raw material are as follows: the Radix Pulsatillae 20 parts, Cortex Fraxini 15 parts, Rhizoma Coptidis 20 parts, Semen Plantaginis 15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, Fructus Chebulae 15 parts are prepared from.Its preparation method is: (1) takes each Chinese medicine by formula ratio; (2) Chinese medicine is pulverized, cross 60 mesh sieves; (3) mix 15 minutes and obtain Chinese medicine powder; (4) Chinese medicine powder is pressed every bag of 100g subpackage, get product.
Embodiment 3
Be used for the treatment of a Chinese powder medicine for fox clostridieum welchii disease, the parts by weight of each raw material are as follows: the Radix Pulsatillae 16 parts, Cortex Fraxini 14 parts, Rhizoma Coptidis 15 parts, Semen Plantaginis 12 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 25 parts, Fructus Chebulae 18 parts are prepared from.Its preparation method is: (1) takes each Chinese medicine by formula ratio; (2) Chinese medicine is pulverized, cross 60 mesh sieves; (3) mix 15 minutes and obtain Chinese medicine powder; (4) Chinese medicine powder is pressed every bag of 100g subpackage, get product.
Clinical trial
Rongcheng City of Shandong Province has raised fox field fox 289 altogether.Find during It is the end of summer, just turning into autumn that diarrhoea appears in indivedual fox, after 2d, fox diarrhoea increases the weight of and occurs hemafecia, falls ill 20 altogether, 6 months mean aves.3d has 10 sick Vulpes dead.The state of an illness spreads gradually full group.The visible sick Vulpes lassitude of their early stage, appetite declines, diarrhoea, loose and watery stool, and color change is little.Diarrhoea is violent subsequently, and row is mixed with the feces of a large amount of blood, and color is comparatively dark, has bad smell, and body temperature raises, and 41 ~ 41.5 DEG C, does not eat.Cut open inspection to die of illness fox, pathological changes mainly concentrates on digestive tract, and gastric mucosa has the ecchymosis differed in size, duodenal mucosa obvious tumefaction, and mucus increases, hemorrhage very serious, in diffuse hemorrhage.Have blood in jejunum and ileum, but intestinal mucosa is not hemorrhage, just mucus increases, and mesenteric adenophyma is large, congested, hemorrhage, and the change of other organs is not obvious.Core blood, liver, spleen and duodenum content through Gram’s staining, finds that the bacillus that the slightly blunt circle in two ends is thick, Gram’s staining are positive, outside thalline, have the pod membrane that one deck is thicker.By clinical symptoms, cut open inspection change and bacteriology checking, be finally diagnosed as fox clostridieum welchii disease.Isolate disease Vulpes immediately, the whole audience is carried out disinfection, stop feeding unclean rotten feedstuff immediately.Sick Vulpes 98 is divided into three groups at random.First group of Chinese powder medicine that 33 spices are fed obtained by embodiment 1, every 100g Chinese powder medicine: 50Kg feedstuff, once a day, connects and feeds 7 days.Second group 33 with gentamycin, dosage is 2mg/Kg body weight, intramuscular injection, once a day, is used in conjunction 3 ~ 5 days.3rd group 32 with baytril, dosage is 1ml/Kg body weight, intramuscular injection, once a day, is used in conjunction 3 ~ 5 days.Observe each group of curative effect, diarrhoea stops, and stool is normal, and body temperature, spirit, appetite all recover normal for curing; Diarrhoea number of times obviously reduces, and defecate body formed greatly, body temperature, spirit, appetite revert to effectively all substantially; Little even to worsen dead be invalid in change after treatment and before treatment.The results are shown in Table 1:
Table 1: different pharmaceutical treatment fox clostridieum welchii disease comparitive study
| Group | First group | Second group | 3rd group |
| Medicine | Chinese powder medicine | Gentamycin | Baytril |
| Treatment time | Oral, qd, 7d | Intramuscular injection, qd, 3 ~ 5d | Intramuscular injection, qd, 3 ~ 5d |
| Case load (only) | 33 | 33 | 32 |
| Cure (only) | 28 | 25 | 23 |
| Effectively (only) | 2 | 1 | 1 |
| Invalid (only) | 3 | 7 | 8 |
| Cure rate (%) | 84.8 | 75.8 | 71.9 |
As can be seen from Table 1, first group uses the Chinese powder medicine treatment fox clostridieum welchii disease obtained by the present invention, and cure rate is 84.8%, and effective percentage is 90.9%.Second group of gentamicin treatment group cure rate is 75.8%, and effective percentage is 78.8%.3rd group of baytril treatment group cure rate is 71.9%, and effective percentage is 75%.As can be seen here, treatment by Chinese herbs group be no matter cure rate or effective percentage all higher than conventional antibiotic therapy group, and there is significant significant difference, P > 0.05.And treatment by Chinese herbs fox clostridieum welchii disease does not produce drug resistance, there is not drug residue, safer.
The above, be only preferred embodiments of the present invention, is illustrative instead of determinate, can list several embodiments according to limited range, therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (5)
1. be used for the treatment of a Chinese medicine composition for fox clostridieum welchii disease, it is characterized in that, be prepared from by the raw material of following mass fraction:
Radix Pulsatillae 16-30 part, Cortex Fraxini 12-15 part, Rhizoma Coptidis 15-20 part, Semen Plantaginis 10-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-25 part, Fructus Chebulae 10-18 part.
2. a kind of Chinese medicine composition being used for the treatment of fox clostridieum welchii disease according to claim 1, is characterized in that: the mass fraction of optimum feed stock is as follows:
The Radix Pulsatillae 30 parts, Cortex Fraxini 12 parts, Rhizoma Coptidis 18 parts, Semen Plantaginis 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20 parts, Fructus Chebulae 10 parts.
3. the Chinese medicine composition for the treatment of fox clostridieum welchii disease according to claim 1 and 2, is characterized in that: this Chinese medicine composition is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
4. the Chinese medicine composition for the treatment of fox clostridieum welchii disease according to claim 3, is characterized in that: described preparation can be powder.
5. prepare a method for the Chinese powder medicine for the treatment of fox clostridieum welchii disease as claimed in claim 4, it is characterized in that, preparation method is: (1) takes each Chinese medicine by formula ratio; (2) Chinese medicine is pulverized, cross 40-80 mesh sieve; (3) mix 10-15 minute and obtain Chinese medicine powder; (4) Chinese medicine powder is pressed every bag of 100-200g subpackage, get product.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078522A (en) * | 2009-11-27 | 2011-06-01 | 天津瑞普生物技术股份有限公司 | Chinese medicine composition for treating enterovirus syndrome in chicken |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078522A (en) * | 2009-11-27 | 2011-06-01 | 天津瑞普生物技术股份有限公司 | Chinese medicine composition for treating enterovirus syndrome in chicken |
Non-Patent Citations (1)
| Title |
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| 王海霞: "白头翁汤治疗羔羊痢疾的临床效果试验", 《黑龙江畜牧兽医》 * |
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