CN104055891A - Coccidiosis control traditional Chinese medicine composition for rabbits and preparation method thereof - Google Patents
Coccidiosis control traditional Chinese medicine composition for rabbits and preparation method thereof Download PDFInfo
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- CN104055891A CN104055891A CN201410311706.XA CN201410311706A CN104055891A CN 104055891 A CN104055891 A CN 104055891A CN 201410311706 A CN201410311706 A CN 201410311706A CN 104055891 A CN104055891 A CN 104055891A
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Abstract
The invention relates to a coccidiosis control traditional Chinese medicine composition for rabbits. The composition comprises radix puerariae, radix scutellariae, antifebrile dichroa, Chinese pulsatilla roots, sophora flavescens, cyrtomium rhizome, rhizoma coptidis, cape jasmine fruit, radix astragali and radix glycyrrhizae. The traditional Chinese medicine composition can be oral liquid, and is prepared through the steps that first, the traditional Chinese medicine materials are smashed, weighted and mixed so that traditional Chinese medicine powder can be obtained; second, a mixture of the traditional Chinese medicine powder and water is put into an extraction tank to carry out soaking; third, a hydrolysate is heated and extracted; fourth, dregs of a decoction are filtered out, and a filtrate is obtained for use; fifth, the dregs of the decoction are heated and extracted; sixth, dregs of the decoction are filtered out, filtrates are combined, and the finished products are obtained after direct filling. The coccidiosis control traditional Chinese medicine composition for rabbits can effectively prevent and control hepatic coccidiosis, intestinal coccidiosis and mixed type coccidiosis of rabbits, and 95% or more coccidiums can be killed; the therapeutic effect on secondary escherichia coli infection and secondary rotavirus infection due to rabbit coccidiosis is obvious. The coccidiosis control traditional Chinese medicine composition for rabbits has the effects of heat clearing and detoxification, yang raising and diarrhea stop, blood cooling and hemostasis and worm killing.
Description
Technical field
The invention belongs to herbal medicine formulation art, especially a kind of rabbit is with preventing and treating Chinese medicine composition of coccidiosis and preparation method thereof.
Background technology
Coccidiosis is an important restriction factor of rabbit keeping development always, and especially very large to a month young harm of exempting from 6 week age to 5, coccidiosis reaches 100% to the infection rate of young rabbit, if can not accomplish good control, mortality rate reaches 60%~70% at least.Rabbit coccidiosis, for the multiple Men Aimei otology Eimeria in top, can be divided into intestinal, liver, mixing three types by the position of coccidiosis parasitism, clinically occurs mainly with mixed type.Sick rabbit shows as lassitude, loss of appetite or absolutely useless, and fur is fluffy and disorderly, does not prostrately rise, and two without god, an eye nasal discharge increases, and eye conjunctiva is pale, diarrhoea, growth retardation, becomes thin, and sometimes diarrhoea and constipation be appearance alternately.Children rabbit mostly is acute process, falls down to the ground suddenly, and muscle spasm, head, to layback, utters a heartrending cry, and hind leg stretches and slides and dead, and chronic person is common with intractable diarrhea, and liver type abdominal circumference increases, and sagging, there is pain palpation hepatic region, mucosa xanthochromia.Coccidiosis is still one of the most serious disease of harm rabbit at present, and market solves coccidiosis and mainly relies on the medicines such as sulfonamides, triazines, polyethers, quinolines.Not only the abuse of coccidiostat is not controlled Rabbit Coccidiosis, can cause on the contrary drug resistance and the medicine residue problem in Carnis Leporis.
It is low that Chinese medicine has toxic and side effects, no drug residue, the advantage of environmental protection.According to traditional Chinese medical science viewpoint, coccidiosis body is pathogenic factor, heat-clearing and toxic substances removing, and yang invigorating antidiarrheal, cooling blood for hemostasis, insecticidal materials, the anticoccidial Chinese medicine that exploitation makes new advances, is the effective way that solves Rabbit Coccidiosis.
Summary of the invention
The problem to be solved in the present invention is: overcome the deficiencies in the prior art, a kind of good effect, no drug residue, safe and reliable rabbit Chinese medicine composition are provided.
Another technical problem that the present invention will solve is: the Chinese medicine formula of a kind of rabbit with control coccidiosis is provided.
For solving the problems of the technologies described above, the technical solution used in the present invention is: the Chinese medicine composition of control coccidiosis for a kind of rabbit, is prepared from by the raw material of following mass fraction: Radix Puerariae 5-10 part, Radix Scutellariae 10-15 part, Radix Dichroae 10-15 part, Radix Pulsatillae 10-15 part, Radix Sophorae Flavescentis 10-15 part, Rhizoma Osmundae 10-15 part, Rhizoma Coptidis 10-15 part, Fructus Gardeniae 10-15 part, Radix Astragali 10-15 part, Radix Glycyrrhizae 10-15 part.
Further, the mass fraction of the optimum feed stock of this Chinese medicine composition is as follows:
10 parts of Radix Puerariaes, 10 parts of Radix Scutellariaes, 10 parts of Radix Dichroaes, 10 parts of the Radix Pulsatillaes, 10 parts of Radix Sophorae Flavescentiss, Rhizoma Osmundae, 10 parts, 10 parts of Rhizoma Coptidis, 10 parts of Fructus Gardeniaes, 10 parts of the Radixs Astragali, 10 parts, Radix Glycyrrhizae.
Further, this Chinese medicine composition is the various conventional extract oral medicine dosage form that contains or do not contain pharmaceutic adjuvant.
Further, described preparation can be oral liquid, and now the input amount of water is 100-300 part.
Another technical problem that the present invention will solve is: the preparation method that the oral liquid formulations of above-mentioned rabbit Chinese medicine composition is provided.
For solving the problems of the technologies described above, the technical solution used in the present invention is: the preparation method of the oral liquid formulations of said composition is: Chinese medicine powder is broken to 40-60 order by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder, water are put in extraction pot, soaked 12 hours; (3) hydrolyzed solution is heated to 40-100 DEG C, extracts 8-12 hour; (4) remove by filter medicinal residues, the indwelling of gained filtrate is for subsequent use; (5) medicinal residues are put in extraction pot again, added water, repeating step (3); (6) remove by filter medicinal residues, gained filtrate with extract filtrate mixing for the first time, directly fill gets product.
Advantage and good effect that the present invention has are:
(1) this Chinese medicine composition is according to tcm theory, science compatibility, retain the combined effect of Chinese medicinal formulae determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and use modern means of science and technology to the effective ingredient of most of medical material wherein carry out quantitatively, half-quantitative detection, through clinical verification determined curative effect, it is a kind of green veterinary drug of nuisanceless no drug residue.
(2) Chinese medicine composition provided by the present invention can effectively be prevented and treated Hepar Leporis seu Oryctolagi coccidiosis, and intestinal coccidiosis and mixed type coccidiosis, can reach more than 90% the killing rate of coccidiosis body; Coli-infection due to rabbit coccidiosis secondary and rotavirus infection are also had to obvious therapeutic effect.This prescription has the effect of heat-clearing and toxic substances removing, yang invigorating antidiarrheal, cooling blood for hemostasis, parasite killing, has avoided drug resistance and the residue problem of medicine in Carnis Leporis of chemicals simultaneously.
(3) pharmacology of the each raw material of Chinese medicine of the present invention is:
Radix Puerariae: expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal.
Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, hemostasis.
Radix Dichroae: cut dysentery.
The Radix Pulsatillae: heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.
Radix Sophorae Flavescentis: heat clearing and damp drying, parasite killing, diuresis.
Rhizoma Osmundae: heat-clearing and toxic substances removing, cooling blood for hemostasis, parasite killing.
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.
Fructus Gardeniae: pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.
The Radix Astragali: air making-up and spleen enlivening, ascending up spleen-Qi and Yang, benefit is defended consolidating superficial resistance.
Radix Glycyrrhizae: heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.
Radix Sophorae Flavescentis among formula, Rhizoma Osmundae heat-clearing and toxic substances removing, has effect of parasite killing concurrently, can kill multiple Enterozoa.Radix Puerariae is main rises the gas of the clear sun of taste, plays yang invigorating gas and mends and have loose bowels, and Rhizoma Coptidis, Radix Scutellariae are longer than heat clearing and damp drying, control Jiao in damp and hot retardance, and the Radix Pulsatillae is joined Pericarpium Granati both can relieving diarrhea with astringents, again can astringing to arrest bleeding.Thereby eliminate fast feces band water folder blood, the symptom that dehydration is become thin and spasm is gone into a coma, reduces mortality rate.Radix Dichroae is joined Herba Agrimoniae astringing to arrest bleeding, and relieving diarrhea with astringents dysentery relieving is the common drug of anti-dysentery.As above numerical digit medicine match can play that parasite killing heals, effect of yang invigorating dysentery relieving, astringing to arrest bleeding.Can kill rapidly coccidiosis body, solve hemafecia symptom.Be equipped with Radix Astragali benefiting QI for strengthening the superficies simultaneously, strengthen animal body self-resistance, promote sick body rehabilitation.Radix Glycyrrhizae can coordinating the actions of various ingredients in a prescription, better coordinates all medicines.
Detailed description of the invention
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1
A Chinese medicine oral liquid for control coccidiosis for rabbit, the parts by weight of each raw material are as follows: 10 parts of Radix Puerariaes, 10 parts of Radix Scutellariaes, 10 parts of Radix Dichroaes, 10 parts of the Radix Pulsatillaes, 10 parts of Radix Sophorae Flavescentiss, 10 parts of Rhizoma Osmundae, 10 parts of Rhizoma Coptidis, 10 parts of Fructus Gardeniaes, 10 parts of the Radixs Astragali, 10 parts, Radix Glycyrrhizae, 200 parts, water.Its preparation method is: Chinese medicine powder is broken to 40-60 order by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder, water are put in extraction pot, soaked 12 hours; (3) hydrolyzed solution is heated to 40-100 DEG C, extracts 8-12 hour; (4) remove by filter medicinal residues, the indwelling of gained filtrate is for subsequent use; (5) medicinal residues are put in extraction pot again, added water, repeating step (3); (6) remove by filter medicinal residues, gained filtrate with extract filtrate mixing for the first time, directly fill (every bottle of 250ml) gets product.
Embodiment 2
A Chinese medicine oral liquid for control coccidiosis for rabbit, the parts by weight of each raw material are as follows: 5 parts of Radix Puerariaes, 12 parts of Radix Scutellariaes, 12 parts of Radix Dichroaes, 12 parts of the Radix Pulsatillaes, 12 parts of Radix Sophorae Flavescentiss, 12 parts of Rhizoma Osmundae, 12 parts of Rhizoma Coptidis, 12 parts of Fructus Gardeniaes, 12 parts of the Radixs Astragali, 12 parts, Radix Glycyrrhizae, 180 parts, water.Its preparation method is: Chinese medicine powder is broken to 40-60 order by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder, water are put in extraction pot, soaked 12 hours; (3) hydrolyzed solution is heated to 40-100 DEG C, extracts 8-12 hour; (4) remove by filter medicinal residues, the indwelling of gained filtrate is for subsequent use; (5) medicinal residues are put in extraction pot again, added water, repeating step (3); (6) remove by filter medicinal residues, gained filtrate with extract filtrate mixing for the first time, directly fill (every bottle of 250ml) gets product.
Embodiment 3
A Chinese medicine oral liquid for control coccidiosis for rabbit, the parts by weight of each raw material are as follows: 8 parts of Radix Puerariaes, 14 parts of Radix Scutellariaes, 14 parts of Radix Dichroaes, 14 parts of the Radix Pulsatillaes, 14 parts of Radix Sophorae Flavescentiss, 14 parts of Rhizoma Osmundae, 14 parts of Rhizoma Coptidis, 14 parts of Fructus Gardeniaes, 14 parts of the Radixs Astragali, 14 parts, Radix Glycyrrhizae, 250 parts, water.Its preparation method is: Chinese medicine powder is broken to 40-60 order by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder, water are put in extraction pot, soaked 12 hours; (3) hydrolyzed solution is heated to 40-100 DEG C, extracts 8-12 hour; (4) remove by filter medicinal residues, the indwelling of gained filtrate is for subsequent use; (5) medicinal residues are put in extraction pot again, added water, repeating step (3); (6) remove by filter medicinal residues, gained filtrate with extract filtrate mixing for the first time, directly fill (every bottle of 250ml) gets product.
Clinical trial
Test 1:
A Chongqing rabbit cultivation farm, 50,000 of breeding stocks, fall ill 3,000, are diagnosed as intestinal coccidium infection through cuing open inspection.Wherein 1,000 use the obtained product of embodiment 1.Drink water 300 jin, treat 5 days for every bottle.Second day symptom of medication obviously alleviates, and within the 5th day, except individually serious symptom, jumpbogroup is cured.Cure rate reaches 95.5%.Another 1,000 use sulfa drugs sulfadimidine, treat 7 days, and the 3rd day starts to take effect, and within the 7th day, jumpbogroup is cured, cure rate 84.6%.Also have 1,000 to use triazines medicine diclazuril, treat 7 days, the 3rd day starts to take effect, and within the 7th day, jumpbogroup is cured, and cure rate reaches 81.9%.The results are shown in Table 1.
The obtained product curative effect of evidence embodiment 1 is obviously better than the chemicals of conventional treatment rabbit coccidiosis on market.
Test 2:
Shandong rex rabbit plant, 30,000 of breeding stocks, fall ill 1,000 5 hundred, are diagnosed as mixed type coccidium infection through cuing open inspection.Wherein 500 use the obtained product of embodiment 1.Drink water 300 jin, treat 5 days for every bottle.Second day symptom of medication obviously alleviates, and within the 5th day, except indivedual mixed sense serious symptoms, jumpbogroup is cured.Cure rate reaches 96.7%.Another 500 use sulfa drugs sulfadimidine, treat 7 days, and the 3rd day starts to take effect, and within the 7th day, jumpbogroup is cured, cure rate 74.8%.Another 500 use triazines medicine diclazuril.Treat 7 days, the 3rd day starts to take effect, and within the 7th day, jumpbogroup is cured.Cure rate 71.4%.The results are shown in Table 1.
The obtained product curative effect of evidence embodiment 1 is obviously better than the chemicals of conventional treatment coccidiosis on market.
Other result of the tests are in table 1.
Table 1
The above, be only preferred embodiments of the present invention, is illustrative instead of determinate, can list several embodiment according to limited range, therefore in the variation and the amendment that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (9)
1. a Chinese medicine composition of preventing and treating coccidiosis for rabbit, it is characterized in that: the raw material by following mass fraction is prepared from: Radix Puerariae 5-10 part, Radix Scutellariae 10-15 part, Radix Dichroae 10-15 part, Radix Pulsatillae 10-15 part, Radix Sophorae Flavescentis 10-15 part, Rhizoma Osmundae 10-15 part, Rhizoma Coptidis 10-15 part, Fructus Gardeniae 10-15 part, Radix Astragali 10-15 part, Radix Glycyrrhizae 10-15 part.
2. the Chinese medicine composition of control coccidiosis for rabbit according to claim 1, is characterized in that: the mass fraction of optimum feed stock is as follows:
10 parts of Radix Puerariaes, 10 parts of Radix Scutellariaes, 10 parts of Radix Dichroaes, 10 parts of the Radix Pulsatillaes, 10 parts of Radix Sophorae Flavescentiss, Rhizoma Osmundae, 10 parts, 10 parts of Rhizoma Coptidis, 10 parts of Fructus Gardeniaes, 10 parts of the Radixs Astragali, 10 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition of control coccidiosis for rabbit according to claim 1 and 2, is characterized in that: this Chinese medicine composition is the various conventional extract oral medicine dosage form that contains or do not contain pharmaceutic adjuvant.
4. the Chinese medicine composition of control coccidiosis for rabbit according to claim 3, is characterized in that: described preparation can be oral liquid, and now the input amount of water is 100-300 part.
5. a method of preparing the Chinese medicine composition of rabbit as claimed in claim 4 control coccidiosis, is characterized in that: preparation method is: (1) pulverizes Chinese medicine, takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder, water are put in extraction pot and soaked; (3) by hydrolyzed solution heating, extract; (4) remove by filter medicinal residues, the indwelling of gained filtrate is for subsequent use; (5) medicinal residues are put in extraction pot again, added water, repeating step (3).(6) remove by filter medicinal residues, gained filtrate with extract filtrate mixing for the first time, directly fill gets product.
6. the preparation method of the Chinese medicine composition of control coccidiosis for rabbit according to claim 5, is characterized in that: described pulverizing order number is 40-60 order.
7. the preparation method of the Chinese medicine composition of control coccidiosis for rabbit according to claim 5, is characterized in that: described soak time is 12 hours.
8. the preparation method of the Chinese medicine composition of control coccidiosis for rabbit according to claim 5, is characterized in that: described heating-up temperature scope is 40-100 DEG C.
9. the preparation method of the Chinese medicine composition of control coccidiosis for fowl according to claim 5, is characterized in that: described extraction time is 8-12 hour.
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Cited By (3)
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CN107397931A (en) * | 2017-09-06 | 2017-11-28 | 安庆市柯旷动物药业有限公司 | A kind of herbal medicine for treating beaver rabbit global-worm illness |
CN110301544A (en) * | 2019-08-08 | 2019-10-08 | 河南省科学院生物研究所有限责任公司 | A kind of rabbit dissipates Chinese herbal medicine premix with gut purge |
CN113317273A (en) * | 2021-06-11 | 2021-08-31 | 四川省畜牧科学研究院 | Construction method of bacterial enteritis model of young rabbits |
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Cited By (3)
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CN113317273A (en) * | 2021-06-11 | 2021-08-31 | 四川省畜牧科学研究院 | Construction method of bacterial enteritis model of young rabbits |
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