CN101194995B - Proprietary Chinese medicine for treating animal virus, bacterium and mix infection - Google Patents

Abstract

The invention relates to an anti virus traditional Chinese medicine, which particularly relates to a traditional Chinese medicine for curing animal viruses, bacteria and mixed infection. The invention takes parts by weight as unit and comprises following dry raw materials: isatis indigotica 1-18 parts, taraxacum 4-45 parts, honeysuckle 4-45 parts, rehmanniae radix 2-24 parts, eucommia ulmoides 4-45 parts, phellodendron 2-15 parts, anemarrhena 2-24 parts, achyranthes root 2-18 parts, radix scrophulariae 2-18 parts, herba cephalanoploris 3-30 parts, tangerine peel 2-24 parts, myrrh 2-18 parts, clematis armandii 1-15 parts, atractylodes 2-24 parts and bupleurum 1-10 parts, which are made into a powder or an injection. The Chinese traditional compound medicine of the invention has both the principal and the secondary aspects for curing animal viruses, bacteria diseases, good effect for curing mild type hog cholera, and has convenient use, low cost, cure rate is above 80%, total effective rate is above 94%, and the invention has a good effect in the aspect of preventing the diseases.

Description

The Chinese patent medicine of treatment animal virus, antibacterial and mixed infection thereof

One, technical field:

The present invention relates to a kind of anti virus herb, particularly relate to a kind of Chinese patent medicine for the treatment of animal virus, antibacterial and mixed infection thereof.

Two, background technology:

At present, along with the raising day by day of living standards of the people, people are also more and more higher to the demand of meat, egg, milk.Yet domestic animal and poultry but are subjected to the invasion and attack of plague virus such as fowl plague, swine fever constantly in raising, have caused the death of large quantities of domestic animals and poultry, have brought enormous economic loss for the raising cause.Virus is one of disease of serious harm animal husbandry development, in recent years, along with the constantly perfect of system of preventing epidemic, significant change has taken place in pathogeneticing characteristic and onset state, be not true to type by the original typical characteristic utmost point that becomes, it is gradual through still animal husbandry being brought about great losses that the course of disease is.Pestilence such as fowl plague, swine fever is viral disease, virus can only be in living cells growth and breeding, in experiment in vitro antivirus action excellent drug, in the body during experiment since living cells to the selective permeation effect of material, cause the drug level that enters living cells very low, be difficult to reach therapeutic effect.How just can make body produce specific antiviral substance in cell, kill intravital virus, improve the antiviral function of domestic animal, be plague virus such as current treatment fowl plague, swine fever and development animal husbandry one the very problem of significant and research.

Along with deepening continuously of new veterinary drug research, many veterinary scientific workers, according to Chinese medicine theoretical basis, develop the novel formulation that many curative effects are equal to or are better than chemicals, antibiotics, and have that toxicity is low, side effect is little, no Drug resistance and advantage such as aberration inducing not, the developing rapidly and deepening continuously of particularly antibiotic along with Chinese crude drug in recent years, antiviral, antitumaous effect research, Chinese crude drug is applied to the livestock and poultry pestilence control and promotes the animal husbandry development aspect more and more to come into one's own.

The disease-resistant Chinese medicine of domestic use mainly contains astragalin injection (No. 1 injection of antiviral), Radix Isatidis injection, injection of Radix Bupleuri.Antipyretic and antitoxic powder is mainly used to the infections chicken cloacal bursa virus disease, and use amount is big, only is used for chicken.But antipyretic and antitoxic powder eliminating fire and detoxication, removing heat from blood cure mainly pyretic toxicity and send out speckle, unconsciousness due to high fever.Clinical practice is to viral disease poor effect such as swine fevers.At present on the veterinary clinic though some Chinese medicine preparation are arranged, injection especially, flavour of a drug are single, and antiviral effect is relatively poor, is not particularly also having a kind of effectively preparation aspect the treatment swine fever.

The patent No. be 97116309.X patent disclosure in a kind of antiviral veterinary medicine injection and preparation method thereof, this patent documentation prescription flavor number is less, lacks relevant curative effect data, uncertain therapeutic efficacy is cut.The patent No. a kind of animal compound Herba Solani Lyrati injection that has been 03124790.3 patent disclosure, this injection has certain curative effect to the fowl bacterial disease, but not satisfactory to the animal viral disease curative effect.

Three, summary of the invention:

The technical problem to be solved in the present invention is the shortcoming that overcomes in the background material, and a kind of treatment animal virus, antibacterial and the more efficiently Chinese patent medicine of mixed infection thereof are provided.

Technical scheme of the present invention:

A kind of Chinese patent medicine for the treatment of animal virus, antibacterial and mixed infection thereof, contain following exsiccant crude drug, with the weight portion is unit, 1～18 part of Radix Isatidis, 4～45 parts of Herba Taraxacis, 4～45 parts of Flos Loniceraes, 2～24 parts in the Radix Rehmanniae, 4～45 parts of the Cortexs Eucommiae, 2～15 parts of Cortex Phellodendris, 2～24 parts of the Rhizoma Anemarrhenaes, 2～18 parts of Radix Achyranthis Bidentataes, 2～18 parts of Radix Scrophulariaes, 3～30 parts of Herba Cirsiis, 2～24 parts of Pericarpium Citri Reticulataes, 2～18 parts of Myrrhas, Caulis Akebiae 1～1 5 part, 2～24 parts of Rhizoma Atractylodis, 1～10 part of Radix Bupleuri.

The Chinese patent medicine of described treatment animal virus, antibacterial and mixed infection thereof, wherein 1～6 part of Radix Isatidis, 4～15 parts of Herba Taraxacis, 4～15 parts of Flos Loniceraes, 2～8 parts in the Radix Rehmanniae, 4～15 parts of the Cortexs Eucommiae, 2～5 parts of Cortex Phellodendris, 2～8 parts of the Rhizoma Anemarrhenaes, 2～6 parts of Radix Achyranthis Bidentataes, 2～8 parts of Radix Scrophulariaes, 3～10 parts of Herba Cirsiis, 2～8 parts of Pericarpium Citri Reticulataes, 2～8 parts of Myrrhas, 1～7 part of Caulis Akebiae, 2～10 parts of Rhizoma Atractylodis, 1～6 part of Radix Bupleuri.

The Chinese patent medicine of described treatment animal virus, antibacterial and mixed infection thereof, wherein 4～18 parts of Radix Isatidiss, 15～45 parts of Herba Taraxacis, 14～45 parts of Flos Loniceraes, 6～20 parts in the Radix Rehmanniae, 4～30 parts of the Cortexs Eucommiae, 3～12 parts of Cortex Phellodendris, 2～20 parts of the Rhizoma Anemarrhenaes, 3～15 parts of Radix Achyranthis Bidentataes, 6～12 parts of Radix Scrophulariaes, 7～20 parts of Herba Cirsiis, 7～24 parts of Pericarpium Citri Reticulataes, 5～18 parts of Myrrhas, 3～15 parts of Caulis Akebiaes, 3～24 parts of Rhizoma Atractylodis, 4～10 parts of Radix Bupleuri.

The Chinese patent medicine of described treatment animal virus, antibacterial and mixed infection thereof, wherein 5～12 parts of Radix Isatidiss, 5～20 parts of Herba Taraxacis, 15～30 parts of Flos Loniceraes, 5～15 parts in the Radix Rehmanniae, 4～25 parts of the Cortexs Eucommiae, 3～10 parts of Cortex Phellodendris, 2～15 parts of the Rhizoma Anemarrhenaes, 2～10 parts of Radix Achyranthis Bidentataes, 5～10 parts of Radix Scrophulariaes, 7～30 parts of Herba Cirsiis, 7～20 parts of Pericarpium Citri Reticulataes, 5～15 parts of Myrrhas, 3～10 parts of Caulis Akebiaes, 4～20 parts of Rhizoma Atractylodis, 1～5 part of Radix Bupleuri.

The powder of the Chinese patent medicine of described treatment animal virus, antibacterial and mixed infection thereof for making according to a conventional method.

The Chinese medicine injection of described treatment animal virus, antibacterial and mixed infection thereof, make by the following method:

(1) takes by weighing Radix Isatidis, Herba Taraxaci, the Cortex Eucommiae, the Rhizoma Anemarrhenae, Cortex Phellodendri, Radix Achyranthis Bidentatae, Herba Cirsii, Pericarpium Citri Reticulatae, Myrrha, Caulis Akebiae, Rhizoma Atractylodis 11 flavor medicines by weight respectively, cut off respectively, mix, add water, 11 flavor medicines: water=1: 10～20, boiled 30～40 minutes, and filtered to get filtrate and medicinal residues; In the gained medicinal residues, add the Radix Rehmanniae, Radix Scrophulariae, Flos Lonicerae, add 10～20 times water, boiled 30～40 minutes, filter to get filtrate and medicinal residues; The water that adds 10～20 times again in medicinal residues boils once again, merges three times filtrate; With the heating of gained filtrate, be concentrated into 95% of 11 flavor crude drug weight; Precipitate with ethanol is three times then, and ethanol content is respectively 60%, 75%, 83% in each mixed liquor, leaves standstill, filters and reclaim ethanol respectively, and adding remove impurity with active carbon matter, cold preservation get medicinal liquid A in gained filtrate, and is standby;

(2) get Radix Bupleuri, Radix Bupleuri is cut off, the water temperature that adds 10～20 times is soaked, and distillate is just collected in distillation; Redistillation is collected re-distilled liquid again, makes 1ml double distilled liquid be equivalent to Radix Bupleuri 1 gram; In double distilled liquid, add polyoxyethylene sorbitan monoleate, polyoxyethylene sorbitan monoleate: the weight ratio of re-distilled liquid=3: 1000, stir, polyoxyethylene sorbitan monoleate is dissolved fully; Add sodium chloride again, sodium chloride: the weight ratio of re-distilled liquid=9: 1000, dissolving, filtration; Add water for injection again, make the 1ml medicinal liquid be equivalent to Radix Bupleuri 1 gram, get medical liquid B, cold preservation, standby;

(3) taking liquid A95 part adds the benzyl alcohol that accounts for medicinal liquid A weight 0.7%, and mixing stirs evenly, and gets medicinal liquid C; Taking liquid B is 5 parts in addition, adds the tween that accounts for medical liquid B weight 0.3%, after the heating for dissolving, gets medicinal liquid D; Medicinal liquid D is joined among the medicinal liquid C, evenly mixed; Regulate pH value to 6.0 with NaOH solution; Add injection water standardize solution at last, make the 1ml medicinal liquid be equivalent to crude drug 1 gram, fine straining, sterilization get final product again.

The pharmacology analysis of Chinese patent medicine of the present invention:

Chinese patent medicine of the present invention can activate immunity function of animal, improve animal body immunity, stops virus, pathogenic bacteria to enter its host cell, and reaches superpower antiviral, antibacterial action.By heat-clearing and toxic substances removing, antibiotic disappearance, blood stasis dispelling loose carbuncle, protect the liver the kidney invigorating, the purpose that the animal body normal function reaches recovery from illness is good for the stomach, recovers in spleen reinforcing.Each medicine compatibility is good, with strong complementarity in the prescription.

Radix Isatidis in the prescription, energy heat-clearing and toxic substances removing, removing heat from blood, sore-throat relieving are with cards such as Flos Lonicerae partner treatment laryngopharynx swelling and pain, aphtha of the mouth and tongue; To bacillus subtilis, Hemolytic streptococcus, sarcine, Bacillus typhi, Salmonella paratyphi, dysentery bacterium, bacillus enteritidis etc. has inhibitory action.Herba Taraxaci, energy heat-clearing and toxic substances removing, mass dissipating and swelling eliminating have the dampness removing effect with Flos Lonicerae is same concurrently with controlling the carbuncle furunculosis, and staphylococcus aureus and various skin fungus are had inhibitory action.The Cortex Eucommiae, energy invigorating the liver and kidney, bone and muscle strengthening, antiabortive have the effect that improves hog cholera immune antibody OD value, and the retention time that can prolong antibody.The Radix Rehmanniae can clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, with the same usefulness of Radix Scrophulariae, can clearing away heat and cooling blood and yin nourishing, and be used for epidemic febrile disease, heat is gone into diseases such as nutrient blood fever of the body xerostomia, red tongue.

Flos Lonicerae can heat-clearing and toxic substances removing, with the same usefulness of Herba Taraxaci, has stronger antipyretic and antidote functions, be usually used in the pyretic toxicity carbuncle, red, swollen, hot, symptom belongs to YANG syndrome person bitterly; Dysentery bacterium, Bacillus typhi, streptococcus, Diplococcus pneumoniae etc. there is inhibitory action.Cortex Phellodendri, clearing away damp-heat, pathogenic fire purging poison, reducing the asthenic fever, dysentery bacterium, Bacillus typhi, escherichia coli, bacillus pyocyaneus, staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae etc. all there is inhibitory action, influenza virus, leptospira, ameba and dermatophytes also there are inhibitory action, can strengthen leukocytic phagocytic activity.

The Rhizoma Anemarrhenae, promotes the production of body fluid at heat clearing away, YIN nourishing, lung moistening, is used for cards such as deficiency of YIN hectic fever, deficiency of the lung cough caused by dryness, the greedy drink of calentura, often and the same usefulness of Cortex Phellodendri, gram negative bacteria and gram positive bacteria and common pathogenic dermatophytes is had inhibitory action.Radix Achyranthis Bidentatae, blood circulation promoting and blood stasis dispelling, conducting blood to flow downwards, inducing diuresis for treating stranguria syndrome, invigorating the liver and kidney have the effect of blood circulation promoting and blood stasis dispelling and conducting blood to flow downwards, with the same usefulness of the Rhizoma Anemarrhenae, can treat the syndrome of fire-heat on tops such as epistaxis, laryngopharynx swelling and pain, aphtha of the mouth and tongue.Radix Scrophulariae, clearing away heat and nourishing YIN, detoxicating and resolving stagnation of pathogens are joined nourishing YIN and clearing away heat detoxifcations such as the Radix Rehmanniae, Cortex Phellodendri, Flos Lonicerae, and bacillus pyocyaneus is had inhibitory action.Herba Cirsii, removing heat from blood, hemostasis, diffusing carbuncle, use together with the Radix Rehmanniae, removing heat from blood, hemostasis, streptococcus pneumoniae, Hemolytic streptococcus, Bacillus typhi, bacillus pyocyaneus, dysentery bacterium and staphylococcus aureus etc. all there is inhibitory action, has the effect that improves hog cholera immune antibody OD value simultaneously, the retention time that can prolong its antibody.

Pericarpium Citri Reticulatae, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Myrrha, blood circulation promoting and blood stasis dispelling, pain relieving granulation promoting, same with Radix Scrophulariae with controlling coagulation of QI-blood, stasis of blood resistance pain.Caulis Akebiae, clearing away heat and promoting diuresis, lactogenesis, with the same usefulness of the Radix Rehmanniae, on heart-fire can be fallen clearly, following can diuresis, gram positive bacteria, dysentery bacterium, typhoid fever are had inhibitory action.Rhizoma Atractylodis, drying damp and strengthening spleen, relieving the exterior syndrome by diaphoresis, wind-damp dispelling; With the same usefulness of Pericarpium Citri Reticulatae, control the spleen and stomach being stranded by dampness, fortuneization mistake department, inappetence, dyspepsia, stomachache and have loose bowels; With the same usefulness of Cortex Phellodendri, have Xin Wen and disperse and induce sweat, again can wind-damp dispelling, control arthralgia, anemofrigid-damp arthralgia.Radix Bupleuri, reducing fever by reconciliation, depressed liver-energy dispersing and QI regulating, elevate a turnable ladder yang-energy have inhibitory action to the growth of tubercule bacillus, influenza virus.

Chinese crude drug that this preparation is used is " People's Republic of China's veterinary drug allusion quotation " 2000 editions two contained certified products, process of preparing Chinese medicine processing all meets veterinary drug allusion quotation standard.

Chinese herbal medicine powder of the present invention claims strange No. of sky again, and Chinese patent medicine injection of the present invention claims strange No. two of sky again.Stability to them is studied, three batch samples are carried out exposure experiments to light 10 days, accelerated test 6 months and long-term room temperature keep sample and investigate 36 months, every indications such as the character of sample, microscopical identification, the outward appearance uniformity, loss on drying have no significant change, and interpret sample stability better.

This product is shallow sepia dried powder, gas fragrance, mildly bitter flavor, suffering; The outward appearance uniformity, loss on drying, according to three batches of two appendix checks of version " Chinese veterinary drug allusion quotation " in 2000 this product, all up to specification.

Outside the virus of this product decapacitation treatment pig, sheep, the bacterial disease, can also treat virus, the bacterial disease of big domestic animal such as cattle, donkey, mule, horse and poultry animal.

The clinical comparison test and the clinical verification of this product

(1) contrast test of disease preventing and treating:

Case 1,

1, materials and methods:

(1) trial drug " strange No. of sky is defended in the Asia " Chinese powder medicine, spice is fed, and serious symptom person boils medicine and gavages.Control drug: the clear temperature *** powder of Chinese medicine, Western medicine moroxydine, mycillin, routine dose medication.

(2) tried the disease pig: be the natural occurrence pig farm, adopting enzyme demarcation property by Henan Province dispensary of bureau of animal husbandry is swine fever mixed infection.

(3) clinical observation on the therapeutic effect is divided into test group and matched group with sick pig at random, respectively with day strange No. one and moroxydine, mycillin treatment, last statistical curative effect.

(4) curative effect judging standard

Cure: sick pig feed desire recovers normal, and body temperature is normal, and feces is normal, and body condition is good.

Produce effects: appetite body temperature progressively recovers, and spirit, defecation, sign are clearly better.

Invalid: treat no significant change or deterioration after 6 days, in addition dead.

2, result of the test

Group	A treatment number	Cure a number (%)	Effective number (%)	Invalid number
					Test group	25	20(80％)	23(92％)	2
Matched group	25	14(56％)	18(72％)	7

Compare by statistics, two groups of cure rates and effective percentage difference is (P＜0.01) extremely significantly, and as seen, this curative effect of medication is definite.

3, brief summary

Observe by therapeutic effect, this medicine has and obviously is better than moroxydine and the mycillin prevention effect to virus and mixed infection thereof, and with Western medicine moroxydine and antibiotic therapy, total effective rate is 72%; Defend day strange No. one with the Asia its mixed infection treated, total effective rate reaches 92%.

Case 2,

Time: in January, 2002

Place: Lian Zi township, Fugou County, Henan

Poultry is main: Guo, Shanxi

Experimental animal: about 40 kilograms of natural occurrence pigs

Plan is examined: the concurrent swine fever mixed infection of Eperythrozoon

Therapeutic scheme: 70 pigs of (1) matched group Shanxi are adopted oxytetracycline 150g, vc0.1 * 200#, virus 0.1 * 300#, antipyretic and antitoxic powder 500g * 4 bag, 100 kilograms of spices, free choice feeding; The peaceful 0.06ml/kg of intramuscular injection Tubifex that does not eat once, Radix Bupleuri 10ml, long-acting terramycin, 0.2ml/kg, an intramuscular injection.

(2) test group Guo's 60 pigs adopt 100 kilograms of feedstuffs to add day strange 250g * 10 bag, ferment powder 500g, spice free choice feeding; The peaceful 0.06ml/kg of intramuscular injection Tubifex once, Radix Bupleuri 10ml intramuscular injection is once.

Result of the test:

Group	A treatment number	Cure a number	Cure rate	A dead number	Mortality rate
						Test group	?60	60	100％	?0	0
Matched group	?70	20	28.6％	?50	71.4％

Case 3,

Time: in June, 2003

Place: Xinmi City plant

Experimental animal: 14 of natural occurrence pigs weigh about 7.5 kilograms.

Plan is examined: be diagnosed as through on-the-spot dissection of Henan Province Vocational and Technical Teachers College animal medicine professor: chronic swine fever.

Testing program: 1. 8 of a brood of serious symptom piglets are 2 in heaven, and every day 2 times, logotype three days are penetrated in remaining 6 employings " day strange No. two " 0.4ml/kg intramuscular injection.2. to 8 piglets of the light disease of another nest, adopt moroxydine/penicillin routine medication, 2 intramuscular injection every day.

Result of the test:

Group	A treatment number	Cure a number (%)	Effective number (%)	Invalid number
					Test group	6	5(83.3％)	6(100％)	0
Matched group	8	0	0	8

Case 4,

Time: in August, 2007

Place: pig farm, Yanjin County, Xinxiang

Experimental animal: natural occurrence pig

Plan is examined: reproductive and respiratory syndrome, swine fever, protozoon mixed infection.

Therapeutic scheme: test group: 1. promptly immunity of 6 dosage of hog cholera lapinised virus vaccine; Methoxy powder spice, strange No. two 0.4ml/kg in intramuscular injection sky between 2. day strange No. one, compound sulfonamide.

Matched group: methoxy powder spice between compound sulfonamide, conventional anti-inflammation, antipyretic-antalgic injection symptomatic treatment.

Result of the test:

Group (number)	Cure a number (%)	A dead number (%)	Invalid number
				Test group (60)	60(100％)	0	0
Matched group (100)	2(2％)	98(98％)	98

Brief summary:

1. the early treatment than treatment of late stage effect for good;

2. day strange No. two with urgent immune combination of hog cholera lapinised virus vaccine, injection respectively has and strengthens or the effect of raising immune effect of vaccine.

3. unite use with antibiotic, have the function that strengthens drug effect alleviation antibiotic side effect.

(2), clinical verification test and analysis

Case 5,

(1) morbidity pig farm: on November 20th, 1999, pig farm, Weihui City, Henan Province, outburst swine diseases poison infects, merges bacteria mixed infection naturally.

(2) sick pig and symptom thereof: 108 of sick pigs, about body weight 40kg, more than the fervescence to 40 ℃, hyperpyrexia is delaied, lassitude, xerostomia happiness drink is not eaten, and fear of cold is afraid of cold, and ear is blue, and skin has petechia and ecchymosis.Use antipyretic and antitoxic powder, moroxydine, antibiotics etc. all invalid, be diagnosed as swine fever virus and bacteria mixed infection.

(3) treatment: in sick pig feed, add the powder Asia and defend day strange No. (serious symptom gavages), guarantee that every pig dosage every day is no less than 200g, logotype 5 days by 3%; Strengthen simultaneously the colony house sterilization is improved feed nutrition, vitimin supplement and saccharide are strengthened thermal insulation and cold resistance, strengthen raising reason etc.

(4) result

Total number	Cure a number	Cure rate	Total effective number	Effective percentage	Invalid number
						108	97	89.8％	102	94.4％	6

As can be seen from the above table, the strange clinical practice in powder sky, cure rate reaches 89.8%, and effective percentage reaches 94.4%.

Case 6,

Time: in May, 2002

Poultry is main: pig farm, Xinmi City, Henan

Condition of illness: main suit, 33 of the porklings that is produced by 4 sows are not cooked the swine Fever Vaccine immunity, about 10 kilograms of body weight, 40.5～41.5 ℃ of body temperature, intramuscular injection penicillin, streptomycin, aminophenazone, moroxydine etc. burn to step back and have some food, after the efficacy of a drug, fever is not eaten again, outbreak repeatedly, skin has the petechia, and defecating stiffly has mucus to adhere to.Be diagnosed as swine fever mixed infection, veterinary station medication in many ways is invalid, in heavenly dies 7.Through dissecting, dead pig lymphadenectasis tangent plane is the marble sample, and there is mound shape infarction at the spleen edge, and larynx mucosal bleeding, lungs have lamellar hemorrhage, and kidney, bladder have diffusivity tip-like petechia, and ileocecal orifice place mucosa has ulcer.

Plan is examined: swine fever mixed infection.

Treatment: 1. rabbitization swine fever attenuated vaccine is promptly inoculated.

2. by per kilogram of body weight 1g days strange No. one, to fry in shallow oil the secondary merging filtrate morning and wait temperature and gavage, medicinal residues are fried in shallow oil the secondary merging filtrate again and gavage afternoons, weigh 2% ratio in material in the material simultaneously and admix day strange No. one and feed.In order to reduce flavour of a drug, every bag of sky strange No. (250g) adds before spice to be admixed in the material after a fresh hen egg stirs evenly again, now mixes now and feeds, free choice feeding 5 days.

Observation of curative effect: medication one day, spirit takes a turn for the better, and the performance of desire food is arranged, and has 24 to open food on the 3rd day, the 4th day 26 all open food, temperature recovery is normal, to the colony house thorough disinfection once, continues to mix in the material days strange No. one 2 days 26 all recoveries from illness, drug withdrawal.On June 8th, 2002 paid a return visit, and did not have recurrence, well-grown.

As seen, the strange clinical practice in powder sky shows that cure rate reaches 100%.

Case 7,

Time: April calendar year 2001

Place: the bohr Yang Chang of Xinmi City, Henan

Experimental animal: natural occurrence boer goat

Clinical symptoms: sick sheep is chronic to become thin, and breathing, breathe slightly of having compeled, normal, the dead paracone of the breathing that has, low or normal when high during body temperature; urine jaundice, stool normally or normal substantially, what have has loose bowels, what have before dead twitches; a strength is shunk, and the extremity paddling that has has nervous symptoms.According to veterinarian in the field: ineffective with medicines such as penicillin and streptomycin, gentamycins, it is not dead even not have an injection, the after-acceleration death of having an injection.Raise main readme: dead 37 (150 Yang Chang) of accumulative total in 1 to March, wherein one is 30,000 yuan of bohr stud rams of buying.On-the-spot dissect three goats, wherein one is when dissecting other two, dead at that time after screaming in the field, dissects in the lump.Find through dissection: there is yellow gelatin mucus in a thoracic cavity, lungs and pleural adhesion, and heart wall is thin to become big, and kidney has ecchymosis, and bladder amasss urine, hilus pulumonis, submandibular lymph nodes enlargement; It is that nephridial tissue is softening that another is typically dissected symptom, manually then easily broken; Last is the many places lymphadenectasis, the spleen enlargement, and kidney has ecchymosis, and blood clotting is bad.

Plan is examined: based on streptococcus, enterotoxemia, contagious pleuropneumonia are that inferior multiple sheep diseases infects.Chemical examination is made a definite diagnosis: the qualitative above-mentioned disease that is is made a definite diagnosis by agricultural university veterinary microorganism research department, effluent south; Wherein streptococcus is carried out separation, screening, and made inactivated vaccine.

Prevent and treat scheme: (1) prevention: the sky is fried in shallow oil four times for strange No. one, is merged medicinal liquid and add in the drinking-water, after waiting to eat grass meal, every day secondary drink.Consumption is: per 100 kg of water add day strange 250g * 10 bag, obtain decoction after the decoction; Or admix by concentrated feed 9%, quantitatively edible. day strange No. one

Treatment: the goat of obvious clinical symptoms is arranged being off one's feed,, decocts merging filtrate, branch secondary drink, logotype 3～5 days four times by per kilogram of body weight 2 gram day strange No. an every day.

Prevention effect:

147 bohrs in this sheep field are purebred and hybridize one, secondary goat, not dead again after the medication.After the one and a half months, inoculated the streptococcus inactivated vaccine of effluent Nan Nongda veterinary biological study chamber trial-production.

Brief summary: not only there is special effect in the sky to the mixed infection of treatment pathogenic bacteria, and aspect prevention good effect is arranged also for strange No. one.This routine cure rate is 100%.

Case 8,

Time: in March, 2002

Place: boer goat field, Lushan County

Experimental animal: bohr stud ram, 8 months, 75 kilograms of body weight.

Clinical symptoms: body temperature, appetite, stool are normal substantially; urine jaundice; back acroparalysis can not be stood, and props up by force, be not able to support oneself and fall down; forelimb right side shoulder has a hard lump; there is pain the part, but preceding pair of limb can stand, and the course of disease has week age; intravenous injection cephalosporin once, crop local injection benzathine penicillin, intramuscular injection VB ₁₂, VB ₁, lame pain disappears, V _FourthMedicines such as colloidality calcium, oral calcium tablet, pill for traumatic injuries, fish liver ball are ineffective.

Therapeutic scheme: a day strange 150g, fry in shallow oil the secondary merging filtrate, gavage the morning, fry in shallow oil medicinal residues again and gavage after secondary merges again afternoon, every day potion, one week of logotype.Prohibit breeding one month.

Therapeutic effect: the energy short walk is manually propped up in beginning in the 3rd day, and the 5th day energy oneself gets up and pasture in institute, but waving still appears in long slightly hind leg of time, the astasia situation; Continue medication, use a day strange 125g every day instead, logotype recovery from illness in 5 days, visit after month, not recurrence again.

Case 9,

Time: in June, 2002

Place: pig farm, Xinmi City

Experimental animal: 120 of natural occurrence pigs, about 50 kilograms of weight.

Diagnosis: qualitative by veterinary dispensary of Henan Province bureau of animal husbandry is the concurrent streptococcus mixed infection of swine fever.

Therapeutic scheme: (1) adds the sky strange No. one, free choice feeding three days in the ratio of feedstuff 3%; Strange No. two of the intramuscular injection sky of not eating (injection of the present invention) is by per kilogram of body weight injection 0.2ml, every day 2 times.

(2) serious sick pig per kilogram of body weight is pressed strange No. two intramuscular injection in 0.4ml days, every day 2 times, logotype 3～5 days.

Effect observation: gently 113 of disease, strange No. two 0.2ml/kg in intramuscular injection sky, the overwhelming majority once begins food, and small part intramuscular injection secondary begins food, still has seven not eat after three days, and the classical symptom that ear is blue, finger pressure does not fade occurs.Adopt doubling dosage to proceed to treat again two days, have six to open food, still have one not eat.The main preparation of poultry sold it at that time, one 100 jin fattening pig, and buyer only gives 30 yuans.Advise through us, continue the injection sky again strange No. two, recovery from illness after two days, this ear has all been burnt, and the pig that walks danger spot has been lived in again, sells with growing and fattening pigs when treating length to more than 170 jin.

Facts have proved: day strange No. two sick pigs to high fever, can improve with the increase effect of dose thereupon.As seen, day strange number, a day is used for strange No. two in this example, and clinical cure rate is 100%.

Case 10,

Time: in October, 2006

Place: pig farm, Tongxu County, Kaifeng

Experimental animal: 80 natural occurrence pigs, 60～65 kilograms of body weight, morbidity successively adopts dexamethasone, lincomycin, aminophenazone treatment 3 days ineffective, is decided to be unknown high fever by the veterinarian of local bureau of animal husbandry, allows abandoning cure.

Plan is examined: reproductive and respiratory syndrome, swine fever mixed infection.

Therapeutic scheme: 1. the ratio in feedstuff 3% adds the sky strange No. one, free choice feeding 5 days;

2. day strange No. two consumption 0.3-0.5ml/kg body weight, 2 intramuscular injection every day, logotype 1～3 day.

Therapeutic effect: fully recover 75, cure rate 93.8%, dead 5, mortality rate accounts for 6.2%.

Case 11,

Time: in May, 2007

Place: 18 li rivers, southern suburbs, Zhengzhou City

Experimental animal: 350 natural occurrence pigs, 30～35 kilograms of body weight.

The main suit: 2006 basic dead intact because of this disease, suffers heavy losses.

Plan is examined: reproductive and respiratory syndrome, swine fever mixed infection.

Therapeutic scheme: 1. day strange No. one 3% ratio spice, free choice feeding 5 days;

2. do not eat food by strange No. two of 0.5ml/kg body weight intramuscular injection sky.

Therapeutic effect: cure 330, cure rate 94.3%; Dead 20, mortality rate 5.7%.

Positive beneficial effect of the present invention:

(1) the research success of Chinese traditional compound medicine of the present invention (strange No. two of day strange number, a day), captured the another great technical barrier of present treatment by Chinese herbs animal virus, bacterial disease treating both the principal and the secondary aspects of a disease at the same time, especially splendid to the atypical swine fever effect, and it is easy to use, cure rate reaches more than 80%, and total effective rate is more than 94%.

(2) Chinese medicine preparation of the present invention not only has special effect to the mixed infection of treatment pathogenic bacteria, and aspect prevention good effect is arranged also.It has remedied because the new problem of treatment of vaccine immunity failure or the low animal virosis that causes of antibody titer, it is better than antiviral western medicine results such as moroxydine, virazoles, and have safety and reliability, have no side effect, the advantage of drug residue free, more help people's health.

(3) forbid using at animal body the appearance of policy along with national antiviral Western medicine, preparation of the present invention is cured the disease at animal body, aspect the diseases prevention, will have better economic and social benefit.

Four, the specific embodiment:

Embodiment one: the Chinese patent medicine injection and the production method thereof of treatment animal virus, antibacterial and mixed infection thereof:

Crude drug is: Radix Isatidis 5 grams, Herba Taraxaci 15 grams, Flos Lonicerae 15 grams, the Radix Rehmanniae 6 grams, the Cortex Eucommiae 4 grams, Cortex Phellodendri 3 grams, the Rhizoma Anemarrhenae 14 grams, Radix Achyranthis Bidentatae 4 grams, Radix Scrophulariae 6 grams, Herba Cirsii 7 grams, Pericarpium Citri Reticulatae 7 grams, Myrrha 5 grams, Caulis Akebiae 3 grams, Rhizoma Atractylodis 3 grams, Radix Bupleuri 3 grams.

Production method: (1) after taking by weighing cuts off Radix Isatidis, Herba Taraxaci, the Cortex Eucommiae, the Rhizoma Anemarrhenae, Cortex Phellodendri, Radix Achyranthis Bidentatae, Herba Cirsii, Pericarpium Citri Reticulatae, Myrrha, Caulis Akebiae, Rhizoma Atractylodis 11 flavor medicines respectively, mix, add water, 11 flavor medicines: water=1: 15 (weight ratio, down together), boiled 30 minutes, filter to get filtrate and medicinal residues, to add the Radix Rehmanniae, Radix Scrophulariae, Flos Lonicerae in the gained medicinal residues again, add 10 times water, boil again, filter 2 times, each 30～40 minutes, merge three times filtrate;

Filtrate is concentrated into per 0.95 gram medicine juice is equivalent to crude drug 1 gram, add ethanol, precipitate with ethanol three times, wherein contain the alcohol amount in the mixed liquor and be respectively 60%, 75%, 83%, leave standstill, filter and reclaim ethanol respectively, in gained filtrate, add 0.3% remove impurity with active carbon matter, cold preservation gets medicinal liquid A, and is standby;

(2) get Radix Bupleuri, Radix Bupleuri is cut off, the water temperature that adds 10～20 times is soaked, and distillate is just collected in distillation; Redistillation is collected double distilled liquid again, makes 1ml double distilled liquid be equivalent to Radix Bupleuri 1 gram; In double distilled liquid, add polyoxyethylene sorbitan monoleate, polyoxyethylene sorbitan monoleate: the weight ratio of re-distilled liquid=3: 1000, stir, polyoxyethylene sorbitan monoleate is dissolved fully; Add sodium chloride again, sodium chloride: the weight ratio of re-distilled liquid=9: 1000, after the dissolving, filter; Add water for injection again, make the 1ml medicinal liquid be equivalent to Radix Bupleuri 1 gram, get medical liquid B, cold preservation is standby;

(3) taking liquid A95 gram adds the benzyl alcohol that accounts for medicinal liquid A weight 0.7%, mixes, and gets medicinal liquid C; Taking liquid B5 gram adds the tween that accounts for medical liquid B weight 0.3% in addition, after the heating for dissolving, gets medicinal liquid D; Medicinal liquid D is joined among the medicinal liquid C, evenly mixed, regulate pH value to 6.0 with NaOH, add injection water standardize solution, make the 1ml medicinal liquid be equivalent to all crude drug 1 grams, fine straining, embedding, sterilization, inspection, the quality certification is pasted in dress box, vanning, and warehouse-in is preserved.

Embodiment two: basic identical with embodiment one, difference is:

Crude drug is: Radix Isatidis 1 gram, Herba Taraxaci 4 grams, Flos Lonicerae 4 grams, the Radix Rehmanniae 2 grams, the Cortex Eucommiae 4 grams, Cortex Phellodendri 2 grams, the Rhizoma Anemarrhenae 2 grams, Radix Achyranthis Bidentatae 2 grams, Radix Scrophulariae 2 grams, Herba Cirsii 3 grams, Pericarpium Citri Reticulatae 2 grams, Myrrha 2 grams, Caulis Akebiae 1 gram, Rhizoma Atractylodis 2 grams, Radix Bupleuri 1 gram.

Embodiment three: basic identical with embodiment one, difference is: crude drug is: Radix Isatidis 18 grams, Herba Taraxaci 45 grams, Flos Lonicerae 45 grams, the Radix Rehmanniae 24 grams, the Cortex Eucommiae 45 grams, Cortex Phellodendri 15 grams, the Rhizoma Anemarrhenae 24 grams, Radix Achyranthis Bidentatae 10 grams, Radix Scrophulariae 18 grams, Herba Cirsii 30 grams, Pericarpium Citri Reticulatae 24 grams, Myrrha 18 grams, Caulis Akebiae 15 grams, Rhizoma Atractylodis 24 grams, Radix Bupleuri 10 grams.

Embodiment four: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 3 grams, Herba Taraxaci 5 grams, Flos Lonicerae 43 grams, the Radix Rehmanniae 3 grams, the Cortex Eucommiae 45 grams, Cortex Phellodendri 15 grams, the Rhizoma Anemarrhenae 11 grams, Radix Achyranthis Bidentatae 4 grams, Radix Scrophulariae 5 grams, Herba Cirsii 15 grams, Pericarpium Citri Reticulatae 3 grams, Myrrha 2 grams, Caulis Akebiae 15 grams, Rhizoma Atractylodis 3 grams, Radix Bupleuri 5 grams.

Embodiment five: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 7 grams, Herba Taraxaci 6 grams, Flos Lonicerae 40 grams, the Radix Rehmanniae 4 grams, the Cortex Eucommiae 43 grams, Cortex Phellodendri 14 grams, the Rhizoma Anemarrhenae 9 grams, Radix Achyranthis Bidentatae 4 grams, Radix Scrophulariae 7 grams, Herba Cirsii 20 grams, Pericarpium Citri Reticulatae 5 grams, Myrrha 5 grams, Caulis Akebiae 13 grams, Rhizoma Atractylodis 5 grams, Radix Bupleuri 5 grams.

Embodiment six: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 9 grams, Herba Taraxaci 8 grams, Flos Lonicerae 37 grams, the Radix Rehmanniae 6 grams, the Cortex Eucommiae 41 grams, Cortex Phellodendri 12 grams, the Rhizoma Anemarrhenae 7 grams, Radix Achyranthis Bidentatae 4 grams, Radix Scrophulariae 9 grams, Herba Cirsii 25 grams, Pericarpium Citri Reticulatae 7 grams, Myrrha 7 grams, Caulis Akebiae 10 grams, Rhizoma Atractylodis 4 grams, Radix Bupleuri 5 grams.

Embodiment seven: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 12 grams, Herba Taraxaci 10 grams, Flos Lonicerae 35 grams, the Radix Rehmanniae 9 grams, the Cortex Eucommiae 37 grams, Cortex Phellodendri 10 grams, the Rhizoma Anemarrhenae 5 grams, Radix Achyranthis Bidentatae 3 grams, Radix Scrophulariae 11 grams, Herba Cirsii 28 grams, Pericarpium Citri Reticulatae 9 grams, Myrrha 9 grams, Caulis Akebiae 8 grams, Rhizoma Atractylodis 7 grams, Radix Bupleuri 6 grams.

Embodiment eight: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 14 grams, Herba Taraxaci 12 grams, Flos Lonicerae 32 grams, the Radix Rehmanniae 12 grams, the Cortex Eucommiae 34 grams, Cortex Phellodendri 8 grams, the Rhizoma Anemarrhenae 3 grams, Radix Achyranthis Bidentatae 2 grams, Radix Scrophulariae 13 grams, Herba Cirsii 30 grams, Pericarpium Citri Reticulatae 10 grams, Myrrha 11 grams, Caulis Akebiae 6 grams, Rhizoma Atractylodis 2 grams, Radix Bupleuri 6 grams.

Embodiment nine: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 16 grams, Herba Taraxaci 15 grams, Flos Lonicerae 30 grams, the Radix Rehmanniae 15 grams, the Cortex Eucommiae 30 grams, Cortex Phellodendri 6 grams, the Rhizoma Anemarrhenae 2 grams, Radix Achyranthis Bidentatae 2 grams, Radix Scrophulariae 15 grams, Herba Cirsii 27 grams, Pericarpium Citri Reticulatae 12 grams, Myrrha 13 grams, Caulis Akebiae 3 grams, Rhizoma Atractylodis 10 grams, Radix Bupleuri 6 grams.

Embodiment ten: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 18 grams, Herba Taraxaci 17 grams, Flos Lonicerae 28 grams, the Radix Rehmanniae 18 grams, the Cortex Eucommiae 27 grams, Cortex Phellodendri 5 grams, the Rhizoma Anemarrhenae 4 grams, Radix Achyranthis Bidentatae 2 grams, Radix Scrophulariae 18 grams, Herba Cirsii 25 grams, Pericarpium Citri Reticulatae 14 grams, Myrrha 15 grams, Caulis Akebiae 2 grams, Rhizoma Atractylodis 12 grams, Radix Bupleuri 4 grams.

Embodiment 11: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 15 grams, Herba Taraxaci 20 grams, Flos Lonicerae 25 grams, the Radix Rehmanniae 23 grams, the Cortex Eucommiae 25 grams, Cortex Phellodendri 4 grams, the Rhizoma Anemarrhenae 6 grams, Radix Achyranthis Bidentatae 2 grams, Radix Scrophulariae 2 grams, Herba Cirsii 23 grams, Pericarpium Citri Reticulatae 16 grams, Myrrha 18 grams, Caulis Akebiae 1 gram, Rhizoma Atractylodis 14 grams, Radix Bupleuri 10 grams.

Embodiment 12: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 11 grams, Herba Taraxaci 22 grams, Flos Lonicerae 22 grams, the Radix Rehmanniae 22 grams, the Cortex Eucommiae 22 grams, Cortex Phellodendri 3 grams, the Rhizoma Anemarrhenae 8 grams, Radix Achyranthis Bidentatae 2 grams, Radix Scrophulariae 4 grams, Herba Cirsii 20 grams, Pericarpium Citri Reticulatae 18 grams, Myrrha 17 grams, Caulis Akebiae 4 grams, Rhizoma Atractylodis 16 grams, Radix Bupleuri 8 grams, Fructus Hordei Germinatus 3 grams.During production, Fructus Hordei Germinatus together adds with Radix Isatidis.

Embodiment 13: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 8 grams, Herba Taraxaci 25 grams, Flos Lonicerae 20 grams, the Radix Rehmanniae 20 grams, the Cortex Eucommiae 20 grams, Cortex Phellodendri 2 grams, the Rhizoma Anemarrhenae 10 grams, Radix Achyranthis Bidentatae 2 grams, Radix Scrophulariae 6 grams, Herba Cirsii 17 grams, Pericarpium Citri Reticulatae 20 grams, Myrrha 15 grams, Caulis Akebiae 4 grams, Rhizoma Atractylodis 20 grams, Radix Bupleuri 4 grams, Fructus Hordei Germinatus 8 grams.Fructus Hordei Germinatus together adds with Radix Isatidis during production.

Embodiment 14: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 5 grams, Herba Taraxaci 27 grams, Flos Lonicerae 17 grams, the Radix Rehmanniae 17 grams, the Cortex Eucommiae 18 grams, Cortex Phellodendri 4 grams, the Rhizoma Anemarrhenae 12 grams, Radix Achyranthis Bidentatae 2 grams, Radix Scrophulariae 8 grams, Herba Cirsii 15 grams, Pericarpium Citri Reticulatae 22 grams, Myrrha 13 grams, Caulis Akebiae 5 grams, Rhizoma Atractylodis 22 grams, Radix Bupleuri 4 grams, Fructus Hordei Germinatus 5 grams.Fructus Hordei Germinatus together adds with Radix Isatidis during production.

Embodiment 15: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 3 grams, Herba Taraxaci 30 grams, Flos Lonicerae 15 grams, the Radix Rehmanniae 15 grams, the Cortex Eucommiae 15 grams, Cortex Phellodendri 5 grams, the Rhizoma Anemarrhenae 14 grams, Radix Achyranthis Bidentatae 2 grams, Radix Scrophulariae 10 grams, Herba Cirsii 13 grams, Pericarpium Citri Reticulatae 24 grams, Myrrha 11 grams, Caulis Akebiae 7 grams, Rhizoma Atractylodis 24 grams, Radix Bupleuri 2 grams, Fructus Hordei Germinatus 7 grams.During production, Fructus Hordei Germinatus together adds with Radix Isatidis.

Embodiment 16: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 2 grams, Herba Taraxaci 32 grams, Flos Lonicerae 12 grams, the Radix Rehmanniae 12 grams, the Cortex Eucommiae 12 grams, Cortex Phellodendri 7 grams, the Rhizoma Anemarrhenae 10 grams, Radix Achyranthis Bidentatae 2 grams, Radix Scrophulariae 12 grams, Herba Cirsii 11 grams, Pericarpium Citri Reticulatae 20 grams, Myrrha 16 grams, Caulis Akebiae 9 grams, Rhizoma Atractylodis 6 grams, Radix Bupleuri 9 grams, Massa Medicata Fermentata 3 grams.Massa Medicata Fermentata together adds with Radix Isatidis during production.

Embodiment 17: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 5 grams, Herba Taraxaci 35 grams, Flos Lonicerae 10 grams, the Radix Rehmanniae 10 grams, the Cortex Eucommiae 10 grams, Cortex Phellodendri 9 grams, the Rhizoma Anemarrhenae 18 grams, Radix Achyranthis Bidentatae 3 grams, Radix Scrophulariae 10 grams, Herba Cirsii 9 grams, Pericarpium Citri Reticulatae 5 grams, Myrrha 9 grams, Caulis Akebiae 11 grams, Rhizoma Atractylodis 4 grams, Radix Bupleuri 7 grams, Massa Medicata Fermentata 8 grams.Massa Medicata Fermentata together adds with Radix Isatidis during production.

Embodiment 18: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 7 grams, Herba Taraxaci 38 grams, Flos Lonicerae 8 grams, the Radix Rehmanniae 8 grams, the Cortex Eucommiae 8 grams, Cortex Phellodendri 11 grams, the Rhizoma Anemarrhenae 20 grams, Radix Achyranthis Bidentatae 3 grams, Radix Scrophulariae 14 grams, Herba Cirsii 7 grams, Pericarpium Citri Reticulatae 8 grams, Myrrha 7 grams, Caulis Akebiae 13 grams, Rhizoma Atractylodis 10 grams, Radix Bupleuri 5 grams, Massa Medicata Fermentata 5 grams.During production, Massa Medicata Fermentata together adds with Radix Isatidis.

Embodiment 19: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 9 grams, Herba Taraxaci 40 grams, Flos Lonicerae 5 grams, the Radix Rehmanniae 5 grams, the Cortex Eucommiae 6 grams, Cortex Phellodendri 13 grams, the Rhizoma Anemarrhenae 22 grams, Radix Achyranthis Bidentatae 4 grams, Radix Scrophulariae 16 grams, Herba Cirsii 5 grams, Pericarpium Citri Reticulatae 11 grams, Myrrha 5 grams, Caulis Akebiae 14 grams, Rhizoma Atractylodis 12 grams, Radix Bupleuri 3 grams, Fructus Hordei Germinatus 3 grams, Massa Medicata Fermentata 6 grams.During production, Fructus Hordei Germinatus, Massa Medicata Fermentata together add with Radix Isatidis.

Embodiment 20: production method is identical with embodiment one, and difference is: crude drug is: Radix Isatidis 11 grams, Herba Taraxaci 42 grams, Flos Lonicerae 4 grams, the Radix Rehmanniae 3 grams, the Cortex Eucommiae 4 grams, Cortex Phellodendri 15 grams, the Rhizoma Anemarrhenae 24 grams, Radix Achyranthis Bidentatae 5 grams, Radix Scrophulariae 18 grams, Herba Cirsii 3 grams, Pericarpium Citri Reticulatae 15 grams, Myrrha 3 grams, Caulis Akebiae 12 grams, Rhizoma Atractylodis 20 grams, Radix Bupleuri 1 gram, Fructus Hordei Germinatus 5 grams, Massa Medicata Fermentata 5 grams.During production, Fructus Hordei Germinatus, Massa Medicata Fermentata together add with Radix Isatidis.

The Chinese patent medicine of embodiment one～20 can be made powder according to a conventional method, specifically may further comprise the steps:

1. remove impurity: the crude drug weighing in will filling a prescription, remove impurity;

2. pulverize and mix: each flavor Chinese medicine is mixed, pulverizes the back cross 60 mesh sieves, mix homogeneously;

3. quality inspection: by pertinent regulations check under two appendix powder items of version " veterinary drug allusion quotation " in 2000;

4. pack:, promptly get Chinese powder medicine of the present invention qualified semi finished package---strange No. one of sky.

Claims (6)

1. Chinese patent medicine for the treatment of animal virus, antibacterial and mixed infection thereof, it is characterized in that: make by following exsiccant crude drug, with the weight portion is unit, 1～18 part of Radix Isatidis, 4～45 parts of Herba Taraxacis, 4～45 parts of Flos Loniceraes, 2～24 parts in the Radix Rehmanniae, 4～45 parts of the Cortexs Eucommiae, 2～15 parts of Cortex Phellodendris, 2～24 parts of the Rhizoma Anemarrhenaes, 2～18 parts of Radix Achyranthis Bidentataes, 2～18 parts of Radix Scrophulariaes, 3～30 parts of Herba Cirsiis, 2～24 parts of Pericarpium Citri Reticulataes, 2～18 parts of Myrrhas, 1～15 part of Caulis Akebiae, 2～24 parts of Rhizoma Atractylodis, 1～10 part of Radix Bupleuri.

2. the Chinese patent medicine of treatment animal virus according to claim 1, antibacterial and mixed infection thereof is characterized in that: wherein 1～6 part of Radix Isatidis, 4～15 parts of Herba Taraxacis, 4～15 parts of Flos Loniceraes, 2～8 parts in the Radix Rehmanniae, 4～15 parts of the Cortexs Eucommiae, 2～5 parts of Cortex Phellodendris, 2～8 parts of the Rhizoma Anemarrhenaes, 2～6 parts of Radix Achyranthis Bidentataes, 2～8 parts of Radix Scrophulariaes, 3～10 parts of Herba Cirsiis, 2～8 parts of Pericarpium Citri Reticulataes, 2～8 parts of Myrrhas, 1～7 part of Caulis Akebiae, 2～10 parts of Rhizoma Atractylodis, 1～6 part of Radix Bupleuri.

3. the Chinese patent medicine of treatment animal virus according to claim 1, antibacterial and mixed infection thereof is characterized in that: wherein 4～18 parts of Radix Isatidiss, 15～45 parts of Herba Taraxacis, 14～45 parts of Flos Loniceraes, 6～20 parts in the Radix Rehmanniae, 4～30 parts of the Cortexs Eucommiae, 3～12 parts of Cortex Phellodendris, 2～20 parts of the Rhizoma Anemarrhenaes, 3～15 parts of Radix Achyranthis Bidentataes, 6～12 parts of Radix Scrophulariaes, 7～20 parts of Herba Cirsiis, 7～24 parts of Pericarpium Citri Reticulataes, 5～18 parts of Myrrhas, 3～15 parts of Caulis Akebiaes, 3～24 parts of Rhizoma Atractylodis, 4～10 parts of Radix Bupleuri.

4. the Chinese patent medicine of treatment animal virus according to claim 1, antibacterial and mixed infection thereof is characterized in that: wherein 5～12 parts of Radix Isatidiss, 5～20 parts of Herba Taraxacis, 15～30 parts of Flos Loniceraes, 5～15 parts in the Radix Rehmanniae, 4～25 parts of the Cortexs Eucommiae, 3～10 parts of Cortex Phellodendris, 2～15 parts of the Rhizoma Anemarrhenaes, 2～10 parts of Radix Achyranthis Bidentataes, 5～10 parts of Radix Scrophulariaes, 7～30 parts of Herba Cirsiis, 7～20 parts of Pericarpium Citri Reticulataes, 5～15 parts of Myrrhas, 3～10 parts of Caulis Akebiaes, 4～20 parts of Rhizoma Atractylodis, 1～5 part of Radix Bupleuri.

5. the Chinese patent medicine of each described treatment animal virus of claim 1 to 4, antibacterial and mixed infection thereof, its powder for making according to a conventional method.

6. the Chinese patent medicine of the described treatment animal virus of claim 1, antibacterial and mixed infection thereof, it is a Chinese medicine injection, it is characterized in that:

(1) takes by weighing Radix Isatidis, Herba Taraxaci, the Cortex Eucommiae, the Rhizoma Anemarrhenae, Cortex Phellodendri, Radix Achyranthis Bidentatae, Herba Cirsii, Pericarpium Citri Reticulatae, Myrrha, Caulis Akebiae, Rhizoma Atractylodis 11 flavor medicines by weight respectively, cut off respectively, mix, add water, 11 flavor medicines: water=1: 10～20, boiled 30～40 minutes, and filtered to get filtrate and medicinal residues; In the gained medicinal residues, add the Radix Rehmanniae, Radix Scrophulariae, Flos Lonicerae, add 10～20 times water, boiled 30～40 minutes, filter to get filtrate and medicinal residues; The water that adds 10～20 times again in medicinal residues boils once again, merges three times filtrate; With the heating of gained filtrate, be concentrated into 95% of 11 flavor crude drug weight; Precipitate with ethanol is three times then, and ethanol content is respectively 60%, 75%, 83% in each mixed liquor, leaves standstill, filters and reclaim ethanol respectively, and adding remove impurity with active carbon matter, cold preservation get medicinal liquid A in gained filtrate, and is standby;

(2) get Radix Bupleuri, Radix Bupleuri is cut off, the water temperature that adds 10～20 times is soaked, and distillate is just collected in distillation; Redistillation is collected re-distilled liquid again, makes 1ml double distilled liquid be equivalent to Radix Bupleuri 1 gram; In double distilled liquid, add polyoxyethylene sorbitan monoleate, polyoxyethylene sorbitan monoleate: the weight ratio of re-distilled liquid=3: 1000, stir, polyoxyethylene sorbitan monoleate is dissolved fully; Add sodium chloride again, sodium chloride: the weight ratio of re-distilled liquid=9: 1000, dissolving, filtration; Add water for injection again, make the 1ml medicinal liquid be equivalent to Radix Bupleuri 1 gram, get medical liquid B, cold preservation, standby;

(3) taking liquid A95 part adds the benzyl alcohol that accounts for medicinal liquid A weight 0.7%, and mixing stirs evenly, and gets medicinal liquid C; Taking liquid B is 5 parts in addition, adds the tween that accounts for medical liquid B weight 0.3%, after the heating for dissolving, gets medicinal liquid D; Medicinal liquid D is joined among the medicinal liquid C, evenly mixed; Regulate pH value to 6.0 with NaOH solution; Add injection water standardize solution at last, make the 1ml medicinal liquid be equivalent to crude drug 1 gram, fine straining, sterilization get final product again.