CN101848908B - 激酶抑制剂的组合物及其在治疗癌症和其它与激酶相关的疾病中的用途 - Google Patents
激酶抑制剂的组合物及其在治疗癌症和其它与激酶相关的疾病中的用途 Download PDFInfo
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- CN101848908B CN101848908B CN200880114705.9A CN200880114705A CN101848908B CN 101848908 B CN101848908 B CN 101848908B CN 200880114705 A CN200880114705 A CN 200880114705A CN 101848908 B CN101848908 B CN 101848908B
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- 0 *c1c(-c(c(*)c2*)c(*)c(C3)c2N(*)C3=O)nc(*)[s]1 Chemical compound *c1c(-c(c(*)c2*)c(*)c(C3)c2N(*)C3=O)nc(*)[s]1 0.000 description 4
- UUJHVQXUVWFTCG-UHFFFAOYSA-N CCNCCNC(C=C(C)C)O Chemical compound CCNCCNC(C=C(C)C)O UUJHVQXUVWFTCG-UHFFFAOYSA-N 0.000 description 1
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Description
Claims (7)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97041007P | 2007-09-06 | 2007-09-06 | |
US60/970,410 | 2007-09-06 | ||
US1338907P | 2007-12-13 | 2007-12-13 | |
US61/013,389 | 2007-12-13 | ||
US7429508P | 2008-06-20 | 2008-06-20 | |
US61/074,295 | 2008-06-20 | ||
PCT/US2008/075418 WO2009033033A2 (en) | 2007-09-06 | 2008-09-05 | Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101848908A CN101848908A (zh) | 2010-09-29 |
CN101848908B true CN101848908B (zh) | 2014-07-02 |
Family
ID=40429714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200880114705.9A Active CN101848908B (zh) | 2007-09-06 | 2008-09-05 | 激酶抑制剂的组合物及其在治疗癌症和其它与激酶相关的疾病中的用途 |
Country Status (16)
Country | Link |
---|---|
US (5) | US8299106B2 (zh) |
EP (2) | EP3037419B1 (zh) |
JP (5) | JP5452490B2 (zh) |
CN (1) | CN101848908B (zh) |
CA (1) | CA2736177A1 (zh) |
CY (1) | CY1118012T1 (zh) |
DK (1) | DK2197878T3 (zh) |
ES (2) | ES2759347T3 (zh) |
HK (2) | HK1148529A1 (zh) |
HR (1) | HRP20161114T1 (zh) |
HU (1) | HUE030774T2 (zh) |
LT (1) | LT2197878T (zh) |
PL (1) | PL2197878T3 (zh) |
PT (1) | PT2197878T (zh) |
SI (1) | SI2197878T1 (zh) |
WO (1) | WO2009033033A2 (zh) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8299106B2 (en) * | 2007-09-06 | 2012-10-30 | Boston Biomedical, Inc. | Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases |
US8605606B2 (en) * | 2007-12-10 | 2013-12-10 | Interdigital Patent Holdings, Inc. | Method and apparatus for triggering radio link control packet discard and radio link control re-establishment |
CA2865819A1 (en) | 2011-02-28 | 2013-09-07 | Mcmaster University | Treatment of cancer with dopamine receptor antagonists |
US9550764B2 (en) | 2012-08-23 | 2017-01-24 | The Institute Of Cancer Research: Royal Cancer Hospital | Fused heterocyclic compounds and their use |
US9227962B2 (en) | 2013-03-13 | 2016-01-05 | Boston Biomedical, Inc. | Heterocyclic substituted-3-heteroarylidenyl-2-indolinone derivative |
US9187454B2 (en) | 2013-03-13 | 2015-11-17 | Boston Biomedical, Inc. | Inhibitors of kinases and cancer stem cells, and methods of preparation and use thereof |
EP2970206A1 (en) * | 2013-03-13 | 2016-01-20 | Boston Biomedical, Inc. | 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer |
JP2016521761A (ja) * | 2013-06-20 | 2016-07-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ampk活性を有するオレフィン置換オキシインドール |
CN106132412A (zh) * | 2014-01-27 | 2016-11-16 | 北京强新生物科技有限公司 | 治疗癌症的新方法 |
US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
CN107683137A (zh) * | 2015-04-27 | 2018-02-09 | 波士顿生物医药有限公司 | 用于使用stat3途径抑制剂和激酶抑制剂治疗癌症的方法 |
US10377749B2 (en) | 2015-08-10 | 2019-08-13 | Sumitomo Dainippon Pharma Co., Ltd. | Purification method for 5-(thiazol-4-yl)indolin-2-one derivative |
WO2017160978A1 (en) | 2016-03-15 | 2017-09-21 | Boston Biomedical, Inc. | Cell cultures and use thereof |
JP2019519573A (ja) | 2016-06-28 | 2019-07-11 | ボストン バイオメディカル, インコーポレイテッド | がんを処置するための方法 |
WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
CA3045306A1 (en) | 2016-11-29 | 2018-06-07 | Boston Biomedical, Inc. | Naphthofuran derivatives, preparation, and methods of use thereof |
SG11202102684VA (en) * | 2018-09-18 | 2021-04-29 | 1 Globe Biomedical Co Ltd | Treatment for non-alcoholic fatty liver disease |
SG11202102683XA (en) * | 2018-09-18 | 2021-04-29 | 1Globe Biomedical Co Ltd | Treatment for obesity |
WO2023081923A1 (en) | 2021-11-08 | 2023-05-11 | Frequency Therapeutics, Inc. | Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0934937B1 (en) * | 1990-11-30 | 2002-02-27 | Otsuka Pharmaceutical Co., Ltd. | Azole derivatives as superoxide radical inhibitor |
WO1998007695A1 (en) | 1996-08-23 | 1998-02-26 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
GB9716557D0 (en) * | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
JP2001517666A (ja) * | 1997-09-23 | 2001-10-09 | 藤沢薬品工業株式会社 | チアゾール誘導体 |
AR034118A1 (es) * | 2000-02-15 | 2004-02-04 | Sugen Inc | Compuestos de 2-indolinonas sustituidas con pirroles inhibidoras de proteinquinasas; sus composiciones farmaceuticas e intermediarios de sintesis |
WO2001064681A2 (en) * | 2000-02-28 | 2001-09-07 | Sugen, Inc. | 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors |
WO2001094312A2 (en) * | 2000-06-02 | 2001-12-13 | Sugen, Inc. | Indolinone derivatives as protein kinase/phosphatase inhibitors |
US20030165873A1 (en) * | 2001-03-02 | 2003-09-04 | Come Jon H. | Three hybrid assay system |
WO2002081466A1 (en) | 2001-04-09 | 2002-10-17 | Sugen, Inc. | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
US20030119839A1 (en) * | 2001-12-13 | 2003-06-26 | Nan-Horng Lin | Protein kinase inhibitors |
SE0200979D0 (sv) * | 2002-03-28 | 2002-03-28 | Astrazeneca Ab | New compounds |
US20050032871A1 (en) * | 2002-09-03 | 2005-02-10 | Sugen, Inc. | Sulfonylated pyrrole-2-indolinone derivatives as kinase inhibitors |
CA2541460A1 (en) | 2003-10-24 | 2005-05-06 | Schering Aktiengesellschaft | Indolinone derivatives and their use in treating disease-states such as cancer |
KR101452520B1 (ko) | 2006-01-27 | 2014-10-21 | 샹하이 헨그루이 파마수티컬 컴퍼니 리미티드 | 피롤로[3,2-c]피리딘-4-온 2-인돌린온 단백질 키나제 억제제 |
AU2008257693B2 (en) * | 2007-06-01 | 2011-01-27 | F. Hoffmann-La Roche Ag | Piperidine-amide derivatives |
US8299106B2 (en) * | 2007-09-06 | 2012-10-30 | Boston Biomedical, Inc. | Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases |
US9187454B2 (en) * | 2013-03-13 | 2015-11-17 | Boston Biomedical, Inc. | Inhibitors of kinases and cancer stem cells, and methods of preparation and use thereof |
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2008
- 2008-09-05 US US12/676,869 patent/US8299106B2/en not_active Expired - Fee Related
- 2008-09-05 HU HUE08829600A patent/HUE030774T2/hu unknown
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- 2008-09-05 JP JP2010524187A patent/JP5452490B2/ja not_active Expired - Fee Related
- 2008-09-05 DK DK08829600.9T patent/DK2197878T3/en active
- 2008-09-05 PT PT88296009T patent/PT2197878T/pt unknown
- 2008-09-05 CA CA2736177A patent/CA2736177A1/en not_active Abandoned
- 2008-09-05 ES ES16156340T patent/ES2759347T3/es active Active
- 2008-09-05 SI SI200831667A patent/SI2197878T1/sl unknown
- 2008-09-05 CN CN200880114705.9A patent/CN101848908B/zh active Active
- 2008-09-05 PL PL08829600T patent/PL2197878T3/pl unknown
- 2008-09-05 EP EP16156340.8A patent/EP3037419B1/en active Active
- 2008-09-05 ES ES08829600.9T patent/ES2591028T3/es active Active
- 2008-09-05 EP EP08829600.9A patent/EP2197878B1/en active Active
- 2008-09-05 LT LTEP08829600.9T patent/LT2197878T/lt unknown
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2011
- 2011-03-21 HK HK11102786.1A patent/HK1148529A1/zh unknown
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2012
- 2012-08-27 US US13/595,708 patent/US20120321622A1/en not_active Abandoned
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2013
- 2013-12-27 JP JP2013272195A patent/JP5701372B2/ja not_active Expired - Fee Related
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2014
- 2014-07-29 US US14/445,783 patent/US9725444B2/en not_active Expired - Fee Related
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2015
- 2015-02-17 JP JP2015028165A patent/JP5974124B2/ja not_active Expired - Fee Related
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2016
- 2016-07-15 JP JP2016140101A patent/JP6495868B2/ja not_active Expired - Fee Related
- 2016-08-31 HR HRP20161114TT patent/HRP20161114T1/hr unknown
- 2016-09-13 CY CY20161100904T patent/CY1118012T1/el unknown
- 2016-12-20 HK HK16114487A patent/HK1226071A1/zh unknown
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2017
- 2017-07-07 US US15/643,608 patent/US20180022743A1/en not_active Abandoned
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2018
- 2018-11-14 US US16/190,669 patent/US20190248781A1/en not_active Abandoned
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2019
- 2019-02-08 JP JP2019021397A patent/JP2019070051A/ja active Pending
Non-Patent Citations (3)
Title |
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Karen Lackey, et al..The Discovery of Potent cRaf1 Kinase Inhibitors.《Bioorganic & Medicinal Chemistry Letters》.2000,第10卷223-226. |
Karen Lackey, et al..The Discovery of Potent cRaf1 Kinase Inhibitors.《Bioorganic & * |
Medicinal Chemistry Letters》.2000,第10卷223-226. * |
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