CN101481363B - 一种制备瑞格列奈的方法 - Google Patents
一种制备瑞格列奈的方法 Download PDFInfo
- Publication number
- CN101481363B CN101481363B CN2008100003470A CN200810000347A CN101481363B CN 101481363 B CN101481363 B CN 101481363B CN 2008100003470 A CN2008100003470 A CN 2008100003470A CN 200810000347 A CN200810000347 A CN 200810000347A CN 101481363 B CN101481363 B CN 101481363B
- Authority
- CN
- China
- Prior art keywords
- formula
- preparation
- benzyl
- acid
- repaglinide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CCOc1cc(CC(N(*)C(CC(C)C)c(cccc2)c2N2CCCCC2)=O)ccc1* Chemical compound CCOc1cc(CC(N(*)C(CC(C)C)c(cccc2)c2N2CCCCC2)=O)ccc1* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (8)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008100003470A CN101481363B (zh) | 2008-01-10 | 2008-01-10 | 一种制备瑞格列奈的方法 |
TW097125652A TW201002668A (en) | 2008-01-10 | 2008-07-08 | Preparing method of repaglinide |
PCT/CN2008/001908 WO2009086728A1 (zh) | 2008-01-10 | 2008-11-24 | 一种制备瑞格列奈的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008100003470A CN101481363B (zh) | 2008-01-10 | 2008-01-10 | 一种制备瑞格列奈的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101481363A CN101481363A (zh) | 2009-07-15 |
CN101481363B true CN101481363B (zh) | 2011-05-04 |
Family
ID=40852795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008100003470A Expired - Fee Related CN101481363B (zh) | 2008-01-10 | 2008-01-10 | 一种制备瑞格列奈的方法 |
Country Status (3)
Country | Link |
---|---|
CN (1) | CN101481363B (zh) |
TW (1) | TW201002668A (zh) |
WO (1) | WO2009086728A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102786498A (zh) * | 2011-05-20 | 2012-11-21 | 江苏豪森医药集团连云港宏创医药有限公司 | 一种制备瑞格列奈的方法 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101781272B (zh) * | 2010-02-11 | 2012-12-05 | 上海百灵医药科技有限公司 | 一种瑞格列奈胺的制备方法及其中间体 |
DK2642999T3 (en) * | 2010-11-23 | 2017-01-09 | Abbvie Ireland Unlimited Co | METHODS OF TREATMENT FOR USING selectivity-VE BCL-2 INHIBITORS |
CN102267959B (zh) * | 2011-07-06 | 2013-05-01 | 海南锦瑞制药股份有限公司 | 一种瑞格列奈晶体、其制备方法及含有该晶体的固体口服制剂 |
CN103012319B (zh) * | 2011-09-20 | 2015-06-10 | 浙江九洲药业股份有限公司 | 瑞格列奈中间体的合成工艺改进 |
CN108129419A (zh) * | 2017-12-22 | 2018-06-08 | 陈益德 | 一种瑞格列奈合成方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1571769A (zh) * | 2001-09-25 | 2005-01-26 | 兰贝克赛实验室有限公司 | 瑞格列奈的制备方法 |
US20070123565A1 (en) * | 2004-07-23 | 2007-05-31 | Aher Umesh P | Donepezil Hydrochloride Form VI |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7915421B2 (en) * | 2003-05-14 | 2011-03-29 | Cilag Ltd. | Method for preparing phenyl acetic acid derivatives |
CN100445275C (zh) * | 2006-06-21 | 2008-12-24 | 浙江大学 | 一种合成瑞格列奈的工艺 |
CN100537552C (zh) * | 2007-05-16 | 2009-09-09 | 江苏豪森药业股份有限公司 | 一种制备瑞格列奈的方法 |
-
2008
- 2008-01-10 CN CN2008100003470A patent/CN101481363B/zh not_active Expired - Fee Related
- 2008-07-08 TW TW097125652A patent/TW201002668A/zh unknown
- 2008-11-24 WO PCT/CN2008/001908 patent/WO2009086728A1/zh active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1571769A (zh) * | 2001-09-25 | 2005-01-26 | 兰贝克赛实验室有限公司 | 瑞格列奈的制备方法 |
US20070123565A1 (en) * | 2004-07-23 | 2007-05-31 | Aher Umesh P | Donepezil Hydrochloride Form VI |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102786498A (zh) * | 2011-05-20 | 2012-11-21 | 江苏豪森医药集团连云港宏创医药有限公司 | 一种制备瑞格列奈的方法 |
Also Published As
Publication number | Publication date |
---|---|
CN101481363A (zh) | 2009-07-15 |
WO2009086728A1 (zh) | 2009-07-16 |
TW201002668A (en) | 2010-01-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101481363B (zh) | 一种制备瑞格列奈的方法 | |
CN101039917A (zh) | 制备替米沙坦的方法 | |
CN102503825A (zh) | 药物中间体丁酮二酸二酯类化合物的制备方法 | |
CN101798270A (zh) | 一种3-氨基-1-金刚烷醇的制备方法 | |
CN102942556A (zh) | 一种苯甲酸阿格列汀的制备工艺 | |
CN105503878A (zh) | 一种阿拉格列汀的合成方法 | |
CN102002021A (zh) | 一种瑞格列奈的新合成方法 | |
CN114315933A (zh) | 一种潜在抗新冠病毒药物莫那匹韦的制备方法 | |
CN100537552C (zh) | 一种制备瑞格列奈的方法 | |
CN102731436A (zh) | 一种瑞格列奈的制备及精制方法 | |
CN102731333A (zh) | 一种丁卡因的制备方法 | |
CN102786498A (zh) | 一种制备瑞格列奈的方法 | |
CN101538253B (zh) | 一种制备瑞格列奈中间体的方法 | |
CN101580460B (zh) | 一种3,4-二羟基苯乙醇的合成方法 | |
CN102424664B (zh) | 一种米格列奈钙的制备方法 | |
CN110407841A (zh) | 一种抗肿瘤药物瑞博西尼的合成方法 | |
CN102924362B (zh) | 一种六氢-2-环戊并吡咯基胺盐酸盐的制备方法 | |
CN103755577B (zh) | 一种从盐酸氨溴索精制母液中回收氨溴索碱的方法 | |
CN108440362A (zh) | 一种维格列汀中间体的制备方法 | |
CN108409650A (zh) | 一种马来酸茚达特罗的制备方法 | |
CN1915982A (zh) | 一种雷诺嗪合成方法 | |
CN101215284B (zh) | 一种改进的依普罗沙坦的制备方法 | |
CN102531922A (zh) | 一种盐酸溴己新的新制备方法 | |
CN1147480C (zh) | 乳清酸生产的工艺方法 | |
CN102180864A (zh) | 一种雷尼酸锶的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1130779 Country of ref document: HK |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: JIANGSU HANSOH PHARMACEUTICAL GROUP LIANYUNGANG HONGCHUANG PHARMACEUTICAL Co.,Ltd. Assignor: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. Contract record no.: 2011320000706 Denomination of invention: Method for preparing Repaglinide Granted publication date: 20110504 License type: Exclusive License Open date: 20090715 Record date: 20110510 |
|
ASS | Succession or assignment of patent right |
Owner name: LIANYUNGANG HONGCHUANG PHARMACEUTICAL CO., LTD. OF Free format text: FORMER OWNER: JIANGSU HAOSEN PHARMACEUTICAL LTD. Effective date: 20110609 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 222047 10TH INDUSTRY RESIDENTIAL QUARTER, DEVELOPMENT ZONE, LIANYUNGANG CITY, JIANGSU PROVINCE TO: 222006 KAITAI ROAD, DAPU INDUSTRIAL ZONE, LIANYUNGANG CITY, JIANGSU PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20110609 Address after: 222006 Jiangsu province Lianyungang Kaitai Dapu Road Industrial Area Patentee after: JIANGSU HANSOH PHARMACEUTICAL GROUP LIANYUNGANG HONGCHUANG PHARMACEUTICAL Co.,Ltd. Address before: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Patentee before: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1130779 Country of ref document: HK |
|
C56 | Change in the name or address of the patentee | ||
CP01 | Change in the name or title of a patent holder |
Address after: 222006 Jiangsu province Lianyungang Kaitai Dapu Road Industrial Area Patentee after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address before: 222006 Jiangsu province Lianyungang Kaitai Dapu Road Industrial Area Patentee before: JIANGSU HANSOH PHARMACEUTICAL GROUP LIANYUNGANG HONGCHUANG PHARMACEUTICAL Co.,Ltd. |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20160315 Address after: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Patentee after: JIANGSU HANSOH PHARMACEUTICAL GROUP Co.,Ltd. Address before: 222006 Jiangsu province Lianyungang Kaitai Dapu Road Industrial Area Patentee before: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110504 Termination date: 20220110 |
|
CF01 | Termination of patent right due to non-payment of annual fee |