CN101351211A - 三萜烯醌和三萜烯酚衍生物及其在***和寄生虫病中的应用 - Google Patents

三萜烯醌和三萜烯酚衍生物及其在***和寄生虫病中的应用 Download PDF

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Publication number
CN101351211A
CN101351211A CNA2006800499371A CN200680049937A CN101351211A CN 101351211 A CN101351211 A CN 101351211A CN A2006800499371 A CNA2006800499371 A CN A2006800499371A CN 200680049937 A CN200680049937 A CN 200680049937A CN 101351211 A CN101351211 A CN 101351211A
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hydrogen
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Chinese (zh)
Inventor
胡安·卡洛斯·劳科尔圣胡安
安娜·拉米勒纳德莫利纳
莫妮卡·巴尼兹卡罗尼尔
安琪儿·谷提勒兹若瓦罗
安娜·埃斯特伍兹布劳恩
道尔斯·亚兹明码萨斯瓦瑞奥
伊利莎·佩雷斯萨科奥
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Consejo Superior de Investigaciones Cientificas CSIC
Universidad de La Laguna
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Consejo Superior de Investigaciones Cientificas CSIC
Universidad de La Laguna
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Publication of CN101351211A publication Critical patent/CN101351211A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
CNA2006800499371A 2005-12-30 2006-12-29 三萜烯醌和三萜烯酚衍生物及其在***和寄生虫病中的应用 Pending CN101351211A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200503263A ES2277568B1 (es) 2005-12-30 2005-12-30 Derivados de triterpenoquinona y triterpenofenoles y su aplicacion para el tratamiento de tumores y enfermedades parasitarias.
ESP200503263 2005-12-30

Publications (1)

Publication Number Publication Date
CN101351211A true CN101351211A (zh) 2009-01-21

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ID=37946257

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800499371A Pending CN101351211A (zh) 2005-12-30 2006-12-29 三萜烯醌和三萜烯酚衍生物及其在***和寄生虫病中的应用

Country Status (11)

Country Link
EP (1) EP1976533A2 (ko)
JP (1) JP2009522239A (ko)
KR (1) KR20080083044A (ko)
CN (1) CN101351211A (ko)
AU (1) AU2006334359A1 (ko)
BR (1) BRPI0620845A2 (ko)
CA (1) CA2635318A1 (ko)
ES (1) ES2277568B1 (ko)
MX (1) MX2008008556A (ko)
RU (1) RU2008131311A (ko)
WO (1) WO2007077203A2 (ko)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018006804A1 (zh) * 2016-07-04 2018-01-11 厦门大学 孤儿核受体Nur77的配体及其用途
CN113827599A (zh) * 2021-09-23 2021-12-24 天津国际生物医药联合研究院 去甲泽拉木醛在抗登革病毒感染中的潜在应用
CN116023426A (zh) * 2022-12-30 2023-04-28 上海海洋大学 去甲泽拉木醛衍生物及其在制备抗癌药物中的应用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103215351A (zh) 2005-04-13 2013-07-24 科学研究高等机关 鉴定用于癌症治疗的化合物的体外方法
WO2009026163A1 (en) * 2007-08-17 2009-02-26 Burnham Institute For Medical Research Compositions and methods for inhibiting growth and metastasis of melanoma
CN101434635B (zh) * 2007-11-16 2012-05-16 上海华拓医药科技发展股份有限公司 一类具抗肿瘤活性的水溶性酚性三萜化合物及其制备方法
US20100068302A1 (en) * 2008-09-17 2010-03-18 Traslational Cancer Drugs Pharma, S.L. Methods and compositions for the treatment of cancer
WO2010049173A1 (en) * 2008-10-31 2010-05-06 Cenix Bioscience Gmbh Use of inhibitors of host kinases for the treatment of infectious diseases
US8691977B2 (en) * 2010-08-23 2014-04-08 Neupharma, Inc. Certain chemical entities, compositions, and methods
US10662218B2 (en) 2015-10-23 2020-05-26 Erx Pharmaceuticals, Inc. Analogs of celastrol
WO2018019681A1 (en) 2016-07-25 2018-02-01 Nerviano Medical Sciences S.R.L. Purine and 3-deazapurine analogues as choline kinase inhibitors
EP3652177A1 (en) 2017-07-11 2020-05-20 Nerviano Medical Sciences S.r.l. Pyrazolo-quinazoline derivatives as choline kinase inhibitors
US20220241214A1 (en) 2019-06-20 2022-08-04 University Of Iowa Research Foundation Nanoparticles comprising quinone w methides and compositions for use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328309A (en) * 1980-07-02 1982-05-04 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Method for producing tripdiolide, triptolide and celastrol
DE4117854A1 (de) * 1991-05-31 1992-12-03 Wiemann Wolfram Verwendung mindestens eines celastroloids als bestandteil fuer ein arzneimittel zur behandlung von erkrankungen des rheumatoiden formenkreises, insbesondere rheumatismus
US5650167A (en) * 1995-11-16 1997-07-22 Dawa Incorporated Method and composition for treating hepatitis B
ES2117950B1 (es) 1996-08-02 1999-09-16 Univ Granada Nuevos compuestos que bloquean la biosintesis de fosforilcolina y su uso como segundo mensajero en proliferacion celular.
CN1155610C (zh) * 2002-11-05 2004-06-30 浙江大学 具有抗氧化和抗肿瘤活性扁蒴藤素系列衍生物及合成方法
US20040220267A1 (en) * 2003-02-07 2004-11-04 Devlin J. P. Derivatives of pentacyclic nortriterpene quinone methides as compounds useful in the treatment of inflammatory, neurodegenerative, and neoplastic diseases

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018006804A1 (zh) * 2016-07-04 2018-01-11 厦门大学 孤儿核受体Nur77的配体及其用途
CN108026141A (zh) * 2016-07-04 2018-05-11 厦门大学 孤儿核受体Nur77的配体及其用途
CN108026142A (zh) * 2016-07-04 2018-05-11 厦门大学 孤儿核受体Nur77 的配体及其用途
US10808005B2 (en) 2016-07-04 2020-10-20 Ixmedicine (Xiamen) Biological Technology Company Limited Ligand for orphan nuclear receptor Nur77 and uses thereof
CN108026141B (zh) * 2016-07-04 2022-03-29 艾凯奇（厦门）生物科技有限公司 孤儿核受体Nur77的配体及其用途
CN108026142B (zh) * 2016-07-04 2022-07-08 艾凯奇（厦门）生物科技有限公司 孤儿核受体Nur77的配体及其用途
CN113827599A (zh) * 2021-09-23 2021-12-24 天津国际生物医药联合研究院 去甲泽拉木醛在抗登革病毒感染中的潜在应用
CN116023426A (zh) * 2022-12-30 2023-04-28 上海海洋大学 去甲泽拉木醛衍生物及其在制备抗癌药物中的应用

Also Published As

Publication number Publication date
RU2008131311A (ru) 2010-02-10
ES2277568A1 (es) 2007-07-01
WO2007077203A2 (en) 2007-07-12
BRPI0620845A2 (pt) 2011-11-22
CA2635318A1 (en) 2007-07-12
AU2006334359A2 (en) 2008-08-07
KR20080083044A (ko) 2008-09-12
AU2006334359A1 (en) 2007-07-12
JP2009522239A (ja) 2009-06-11
ES2277568B1 (es) 2008-04-01
EP1976533A2 (en) 2008-10-08
MX2008008556A (es) 2008-09-26
WO2007077203A3 (en) 2007-08-30

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