CN101323629B - 4-{6-[5-(2-氯-6-甲基苯胺甲酰基)-噻唑-2-氨基]-2-甲基嘧啶-4}-哌嗪-1-甲基磷酸二乙酯 - Google Patents
4-{6-[5-(2-氯-6-甲基苯胺甲酰基)-噻唑-2-氨基]-2-甲基嘧啶-4}-哌嗪-1-甲基磷酸二乙酯 Download PDFInfo
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- CN101323629B CN101323629B CN2008100081978A CN200810008197A CN101323629B CN 101323629 B CN101323629 B CN 101323629B CN 2008100081978 A CN2008100081978 A CN 2008100081978A CN 200810008197 A CN200810008197 A CN 200810008197A CN 101323629 B CN101323629 B CN 101323629B
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- piperazine
- thiazole
- methylpyrimidine
- methyl
- amino
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
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Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN2008100081978A CN101323629B (zh) | 2007-02-16 | 2008-02-18 | 4-{6-[5-(2-氯-6-甲基苯胺甲酰基)-噻唑-2-氨基]-2-甲基嘧啶-4}-哌嗪-1-甲基磷酸二乙酯 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN200710064011.6 | 2007-02-16 | ||
CN200710064011 | 2007-02-16 | ||
CN2008100081978A CN101323629B (zh) | 2007-02-16 | 2008-02-18 | 4-{6-[5-(2-氯-6-甲基苯胺甲酰基)-噻唑-2-氨基]-2-甲基嘧啶-4}-哌嗪-1-甲基磷酸二乙酯 |
Publications (2)
Publication Number | Publication Date |
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CN101323629A CN101323629A (zh) | 2008-12-17 |
CN101323629B true CN101323629B (zh) | 2011-08-17 |
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Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
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CN2008100081978A Active CN101323629B (zh) | 2007-02-16 | 2008-02-18 | 4-{6-[5-(2-氯-6-甲基苯胺甲酰基)-噻唑-2-氨基]-2-甲基嘧啶-4}-哌嗪-1-甲基磷酸二乙酯 |
CN2008100081963A Expired - Fee Related CN101265274B (zh) | 2007-02-16 | 2008-02-18 | 嘧啶噻唑胺衍生物、及其制法和药物组合物与用途 |
CN2008100081982A Expired - Fee Related CN101265275B (zh) | 2007-02-16 | 2008-02-18 | 4-{6-[5-(2-氯-6-甲基苯胺甲酰基)-噻唑-2-氨基]-2-甲基嘧啶-4}-哌嗪-1-磷酸二乙酯 |
Family Applications After (2)
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CN2008100081963A Expired - Fee Related CN101265274B (zh) | 2007-02-16 | 2008-02-18 | 嘧啶噻唑胺衍生物、及其制法和药物组合物与用途 |
CN2008100081982A Expired - Fee Related CN101265275B (zh) | 2007-02-16 | 2008-02-18 | 4-{6-[5-(2-氯-6-甲基苯胺甲酰基)-噻唑-2-氨基]-2-甲基嘧啶-4}-哌嗪-1-磷酸二乙酯 |
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CN (3) | CN101323629B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101323629B (zh) * | 2007-02-16 | 2011-08-17 | 江苏正大天晴药业股份有限公司 | 4-{6-[5-(2-氯-6-甲基苯胺甲酰基)-噻唑-2-氨基]-2-甲基嘧啶-4}-哌嗪-1-甲基磷酸二乙酯 |
CN101812060B (zh) * | 2010-02-02 | 2011-08-17 | 南京卡文迪许生物工程技术有限公司 | 一种简捷制备高纯度达沙替尼的新方法以及中间体化合物 |
CN102786517B (zh) * | 2011-05-18 | 2017-06-06 | 中国医学科学院药物研究所 | Gk和ppar双重激动活性的嘧啶噻唑胺类衍生物 |
CN103130740A (zh) * | 2011-11-29 | 2013-06-05 | 长江大学 | 拌种灵的氨基酸衍生物及其作为杀菌剂的用途 |
CN112057451A (zh) * | 2014-12-09 | 2020-12-11 | 正大天晴药业集团股份有限公司 | 治疗非小细胞肺癌的喹啉衍生物 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999003854A1 (en) * | 1997-07-18 | 1999-01-28 | Novartis Ag | Crystal modification of a n-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use |
WO2000062778A1 (en) * | 1999-04-15 | 2000-10-26 | Bristol-Myers Squibb Co. | Cyclic protein tyrosine kinase inhibitors |
WO2005013983A1 (en) * | 2003-07-09 | 2005-02-17 | Bristol-Myers Squibb Company | Combination of src kinase inhibitors and chemotherapeutic agents for the treatment of proliferative diseases |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0126902D0 (en) * | 2001-11-08 | 2002-01-02 | Novartis Ag | Organic compounds |
CN101323629B (zh) * | 2007-02-16 | 2011-08-17 | 江苏正大天晴药业股份有限公司 | 4-{6-[5-(2-氯-6-甲基苯胺甲酰基)-噻唑-2-氨基]-2-甲基嘧啶-4}-哌嗪-1-甲基磷酸二乙酯 |
-
2008
- 2008-02-18 CN CN2008100081978A patent/CN101323629B/zh active Active
- 2008-02-18 CN CN2008100081963A patent/CN101265274B/zh not_active Expired - Fee Related
- 2008-02-18 CN CN2008100081982A patent/CN101265275B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999003854A1 (en) * | 1997-07-18 | 1999-01-28 | Novartis Ag | Crystal modification of a n-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use |
WO2000062778A1 (en) * | 1999-04-15 | 2000-10-26 | Bristol-Myers Squibb Co. | Cyclic protein tyrosine kinase inhibitors |
WO2005013983A1 (en) * | 2003-07-09 | 2005-02-17 | Bristol-Myers Squibb Company | Combination of src kinase inhibitors and chemotherapeutic agents for the treatment of proliferative diseases |
Also Published As
Publication number | Publication date |
---|---|
CN101265274B (zh) | 2013-09-04 |
CN101265274A (zh) | 2008-09-17 |
CN101265275A (zh) | 2008-09-17 |
CN101265275B (zh) | 2012-09-05 |
CN101323629A (zh) | 2008-12-17 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
ASS | Succession or assignment of patent right |
Owner name: JIANGSU ZHENGDA TIANQING DRUG INDUSTRY CO., LTD. Free format text: FORMER OWNER: INST. OF PHARMACOLOGY, CHINESE ACADEMY OF MEDICINE Effective date: 20090515 |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20090515 Address after: No 8 North dragon road, Sinpo District, Jiangsu, Lianyungang Applicant after: Jiangsu Zhengda Tian Qing pharmaceutical Limited by Share Ltd Co-applicant after: Institute of Materia Medica of Chinese Academy of Medical Sciences Address before: Beijing city Xuanwu District Xiannongtan Street No. 1 Applicant before: Institute of Materia Medica of Chinese Academy of Medical Sciences |
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C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER NAME: JIANGSU ZHENGDA TIANQING PHARMACEUTICAL CO., LTD. |
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CP01 | Change in the name or title of a patent holder |
Address after: 210029 No. 8 Julong North Road, Sinpo District, Jiangsu, Lianyungang Patentee after: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Patentee after: Institute of Materia Medica of Chinese Academy of Medical Sciences Address before: 210029 No. 8 Julong North Road, Sinpo District, Jiangsu, Lianyungang Patentee before: Jiangsu Chiatai Tianqing Pharmaceutical Co., Ltd. Patentee before: Institute of Materia Medica of Chinese Academy of Medical Sciences |