CN101049513A - 水溶性壳聚糖基纤维止血愈创材料及其制备方法和应用 - Google Patents
水溶性壳聚糖基纤维止血愈创材料及其制备方法和应用 Download PDFInfo
- Publication number
- CN101049513A CN101049513A CNA2007100157436A CN200710015743A CN101049513A CN 101049513 A CN101049513 A CN 101049513A CN A2007100157436 A CNA2007100157436 A CN A2007100157436A CN 200710015743 A CN200710015743 A CN 200710015743A CN 101049513 A CN101049513 A CN 101049513A
- Authority
- CN
- China
- Prior art keywords
- fiber
- chitosan
- water
- cotton
- woven cloth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000835 fiber Substances 0.000 title claims abstract description 210
- 229920001661 Chitosan Polymers 0.000 title claims abstract description 186
- 230000035876 healing Effects 0.000 title claims abstract description 48
- 239000000463 material Substances 0.000 title claims description 68
- 230000002364 anti-haemorrhagic effect Effects 0.000 title claims description 43
- 230000000472 traumatic effect Effects 0.000 title claims description 43
- 238000002360 preparation method Methods 0.000 title claims description 23
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 84
- -1 carboxymethyl hydroxyethyl Chemical group 0.000 claims abstract description 70
- 229940054190 hydroxypropyl chitosan Drugs 0.000 claims abstract description 22
- 239000004744 fabric Substances 0.000 claims description 88
- 239000004745 nonwoven fabric Substances 0.000 claims description 87
- 229920000742 Cotton Polymers 0.000 claims description 51
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 44
- 229920002101 Chitin Polymers 0.000 claims description 38
- 238000006243 chemical reaction Methods 0.000 claims description 38
- 235000009161 Espostoa lanata Nutrition 0.000 claims description 26
- 240000001624 Espostoa lanata Species 0.000 claims description 26
- 239000003153 chemical reaction reagent Substances 0.000 claims description 25
- 238000006467 substitution reaction Methods 0.000 claims description 25
- 230000001954 sterilising effect Effects 0.000 claims description 22
- 230000029663 wound healing Effects 0.000 claims description 22
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 21
- 239000007864 aqueous solution Substances 0.000 claims description 21
- 239000005977 Ethylene Substances 0.000 claims description 20
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 150000001243 acetic acids Chemical class 0.000 claims description 20
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- 230000023597 hemostasis Effects 0.000 claims description 18
- 239000003513 alkali Substances 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 15
- SZIFAVKTNFCBPC-UHFFFAOYSA-N 2-chloroethanol Chemical compound OCCCl SZIFAVKTNFCBPC-UHFFFAOYSA-N 0.000 claims description 11
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 11
- 238000004659 sterilization and disinfection Methods 0.000 claims description 11
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 10
- 125000001475 halogen functional group Chemical group 0.000 claims description 10
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 10
- 239000001294 propane Substances 0.000 claims description 10
- 239000012429 reaction media Substances 0.000 claims description 10
- LDLCZOVUSADOIV-UHFFFAOYSA-N 2-bromoethanol Chemical compound OCCBr LDLCZOVUSADOIV-UHFFFAOYSA-N 0.000 claims description 9
- 238000004140 cleaning Methods 0.000 claims description 9
- WBJINCZRORDGAQ-UHFFFAOYSA-N ethyl formate Chemical compound CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 239000003960 organic solvent Substances 0.000 claims description 9
- FDRCDNZGSXJAFP-UHFFFAOYSA-M sodium chloroacetate Chemical compound [Na+].[O-]C(=O)CCl FDRCDNZGSXJAFP-UHFFFAOYSA-M 0.000 claims description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 8
- 230000007935 neutral effect Effects 0.000 claims description 8
- 229910052700 potassium Inorganic materials 0.000 claims description 8
- 239000011591 potassium Substances 0.000 claims description 8
- 230000004044 response Effects 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- 238000005406 washing Methods 0.000 claims description 8
- 230000018044 dehydration Effects 0.000 claims description 7
- 238000006297 dehydration reaction Methods 0.000 claims description 7
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 4
- 230000002980 postoperative effect Effects 0.000 claims description 4
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 3
- WEGOLYBUWCMMMY-UHFFFAOYSA-N 1-bromo-2-propanol Chemical compound CC(O)CBr WEGOLYBUWCMMMY-UHFFFAOYSA-N 0.000 claims description 3
- YYTSGNJTASLUOY-UHFFFAOYSA-N 1-chloropropan-2-ol Chemical compound CC(O)CCl YYTSGNJTASLUOY-UHFFFAOYSA-N 0.000 claims description 3
- JDNTWHVOXJZDSN-UHFFFAOYSA-N iodoacetic acid Chemical compound OC(=O)CI JDNTWHVOXJZDSN-UHFFFAOYSA-N 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 2
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical group C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 claims 1
- 208000032843 Hemorrhage Diseases 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 4
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 abstract 1
- 239000002657 fibrous material Substances 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000002439 hemostatic effect Effects 0.000 description 18
- 210000001519 tissue Anatomy 0.000 description 15
- 206010052428 Wound Diseases 0.000 description 13
- 208000027418 Wounds and injury Diseases 0.000 description 13
- 239000000243 solution Substances 0.000 description 13
- 230000000694 effects Effects 0.000 description 12
- 239000000047 product Substances 0.000 description 11
- 238000012360 testing method Methods 0.000 description 9
- 229920002201 Oxidized cellulose Polymers 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 229940107304 oxidized cellulose Drugs 0.000 description 7
- 239000002994 raw material Substances 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 238000005303 weighing Methods 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 230000000740 bleeding effect Effects 0.000 description 6
- 238000012856 packing Methods 0.000 description 6
- 238000001291 vacuum drying Methods 0.000 description 6
- 241000700159 Rattus Species 0.000 description 5
- 230000015556 catabolic process Effects 0.000 description 5
- 238000006731 degradation reaction Methods 0.000 description 5
- 230000000025 haemostatic effect Effects 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 239000013642 negative control Substances 0.000 description 5
- 239000004627 regenerated cellulose Substances 0.000 description 5
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 description 4
- 229940106681 chloroacetic acid Drugs 0.000 description 4
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 4
- 230000002440 hepatic effect Effects 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 230000001476 alcoholic effect Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000001112 coagulating effect Effects 0.000 description 3
- 239000000084 colloidal system Substances 0.000 description 3
- 229960004756 ethanol Drugs 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 238000004154 testing of material Methods 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 230000003187 abdominal effect Effects 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000006196 deacetylation Effects 0.000 description 2
- 238000003381 deacetylation reaction Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000009940 knitting Methods 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 230000005541 medical transmission Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 210000000115 thoracic cavity Anatomy 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241001582888 Lobus Species 0.000 description 1
- QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 1
- 206010058046 Post procedural complication Diseases 0.000 description 1
- 208000035965 Postoperative Complications Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 210000005228 liver tissue Anatomy 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 238000002406 microsurgery Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000002632 myometrial effect Effects 0.000 description 1
- 229960002275 pentobarbital sodium Drugs 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D1/00—Treatment of filament-forming or like material
- D01D1/02—Preparation of spinning solutions
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/06—Wet spinning methods
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Textile Engineering (AREA)
- Veterinary Medicine (AREA)
- Mechanical Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Description
组别 | 实验动物数量(只) | 止血时间(秒) |
阴性对照组氧化纤维素纱布组 | 1212 | >18080-120 |
羧甲基壳聚糖纤维非织布组羟丙基壳聚糖纤维非织布组羟乙基壳聚糖纤维非织布组 | 121212 | ≤20≤30≤30 |
组别 | 7天的试验结果 | 14天的试验结果 | ||
动物数量(只) | 7天的创面愈合情况 | 动物数量(只) | 14天的创面愈合情况 | |
阴性对照组*氧化纤维素纱布组羧甲基壳聚糖纤维非织布组羟丙基壳聚糖纤维非织布组羟乙基壳聚糖纤维非织布组 | 36666 | 创面愈合约20%,组织间粘连严重材料基本降解,形成紫黑色凝胶,创面愈合约40-50%,组织间有粘连材料已降解,创面愈合约70-80%,组织间无粘连材料已降解,创面愈合约70-80%,组织间无粘连材料已降解,创面愈合约70-80%,组织间无粘连 | 46666 | 创面愈合约40-50%,组织间粘连严重材料基本降解,创面有紫黑色凝胶,创面愈合约80-90%,组织间有粘连材料已降解,创面完全愈合,创面平整,组织间无粘连材料已降解,创面完全愈合,创面平整,组织间无粘连材料已降解,创面完全愈合,创面平整,组织间无粘连 |
Claims (9)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200710015743A CN101049513B (zh) | 2007-05-13 | 2007-05-13 | 水溶性壳聚糖基纤维止血愈创材料及其制备方法和应用 |
PCT/CN2008/000636 WO2008138202A1 (en) | 2007-05-13 | 2008-03-31 | A chitosan based fiber material, preparing method and application thereof |
US12/599,769 US20100305489A1 (en) | 2007-05-13 | 2008-03-31 | Chitosan-based fiber material, its preparation method and use |
EP08715072.8A EP2156849B1 (en) | 2007-05-13 | 2008-03-31 | A chitosan based fiber material, preparing method and application thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200710015743A CN101049513B (zh) | 2007-05-13 | 2007-05-13 | 水溶性壳聚糖基纤维止血愈创材料及其制备方法和应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101049513A true CN101049513A (zh) | 2007-10-10 |
CN101049513B CN101049513B (zh) | 2010-05-19 |
Family
ID=38781247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200710015743A Active CN101049513B (zh) | 2007-05-13 | 2007-05-13 | 水溶性壳聚糖基纤维止血愈创材料及其制备方法和应用 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20100305489A1 (zh) |
EP (1) | EP2156849B1 (zh) |
CN (1) | CN101049513B (zh) |
WO (1) | WO2008138202A1 (zh) |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008138202A1 (en) * | 2007-05-13 | 2008-11-20 | Qingdao Biotemed Biomaterial Co., Ltd | A chitosan based fiber material, preparing method and application thereof |
CN102218154A (zh) * | 2010-04-15 | 2011-10-19 | 郑明义 | 羧甲基羟乙基改性棉纤维止血织物及其制备方法 |
CN102373620A (zh) * | 2011-11-11 | 2012-03-14 | 武汉纺织大学 | 一种羟丙基三甲基氯化铵甲壳胺纤维的制备方法 |
CN102371003A (zh) * | 2010-08-18 | 2012-03-14 | 张德华 | 水溶性纤维织物创面敷料及其制备方法 |
CN103143050A (zh) * | 2013-03-08 | 2013-06-12 | 苏州艾美医疗用品有限公司 | 羧甲基壳聚糖创可贴及其制备方法 |
TWI477670B (zh) * | 2011-01-06 | 2015-03-21 | Taiwan Textile Res Inst | 微米級纖維狀止血材料及其製備方法 |
CN104755505A (zh) * | 2012-08-17 | 2015-07-01 | 北卡罗来纳大学查珀尔希尔分校 | 水溶性的释放一氧化氮的聚葡糖胺和其用途 |
CN105568675A (zh) * | 2014-10-14 | 2016-05-11 | 中国海洋大学 | 一种h型羧甲基壳聚糖纤维的制备方法 |
CN106267305A (zh) * | 2016-08-08 | 2017-01-04 | 江苏诺瓦立医疗用品有限公司 | 止血材料 |
CN107724074A (zh) * | 2017-07-31 | 2018-02-23 | 山东人文置业有限公司 | 一种水溶性壳聚糖纤维的制备方法 |
CN107875433A (zh) * | 2017-11-30 | 2018-04-06 | 英泰时尚服饰(苏州)有限公司 | 一种快速止血型针织布的制备方法 |
CN110770373A (zh) * | 2017-06-27 | 2020-02-07 | 科德宝两合公司 | 形成水凝胶的多组分纤维 |
CN111450304A (zh) * | 2020-03-17 | 2020-07-28 | 青岛博益特生物材料股份有限公司 | 一种带正电荷生物纤维止血抑菌材料及其制备方法和应用 |
US11026965B2 (en) | 2018-03-06 | 2021-06-08 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto |
CN113117132A (zh) * | 2019-12-31 | 2021-07-16 | 广州迈普再生医学科技股份有限公司 | 一种可吸收膨胀式纳米短纤维粉状材料及其制备方法和应用 |
US11072668B2 (en) | 2017-01-03 | 2021-07-27 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto |
US11421044B2 (en) | 2018-12-28 | 2022-08-23 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto |
US11723914B2 (en) | 2017-03-28 | 2023-08-15 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing polyaminoglycosides as biodegradable antibacterial scaffolds and methods pertaining thereto |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012088631A1 (zh) * | 2010-12-29 | 2012-07-05 | 山东华兴纺织集团有限公司 | 一种壳聚糖纤维医用敷料及其制备方法 |
RU2468129C2 (ru) * | 2010-12-30 | 2012-11-27 | Государственное образовательное учреждение высшего профессионального образования "Саратовский государственный университет им. Н.Г. Чернышевского" | Биополимерное волокно, состав формовочного раствора для его получения, способ приготовления формовочного раствора, полотно биомедицинского назначения, способ его модификации, биологическая повязка и способ лечения ран |
GB201220076D0 (en) * | 2012-11-07 | 2012-12-19 | Medtrade Products Ltd | Wound care device |
CN103397509A (zh) * | 2013-08-07 | 2013-11-20 | 武汉纺织大学 | 一种抗菌吸液纱布的制备方法 |
JP6416604B2 (ja) * | 2014-12-07 | 2018-10-31 | シンワ株式会社 | キトサンフィルムの製造方法 |
CN104630930B (zh) * | 2015-02-03 | 2016-08-24 | 马晓均 | 一种具有止血功能的纺丝液及其制备方法 |
CN104975504B (zh) * | 2015-07-08 | 2017-03-01 | 陕西科技大学 | 一种o‑羧甲基壳聚糖接枝尼龙66织物制备鞋用抗菌合成革基材及里衬的方法 |
EP3523367A4 (en) | 2016-10-07 | 2020-06-03 | The University Of North Carolina At Chapel Hill | HYPERRAMIFIED POLYESTERS MEDIATED BY S-NITROSOTHIOL |
CN108822321A (zh) * | 2018-07-19 | 2018-11-16 | 佛山皖阳生物科技有限公司 | 一种抑菌医用胶原膜的制备方法 |
CN110983621B (zh) * | 2019-12-25 | 2022-04-29 | 扬州市凯瑞特医疗用品有限公司 | 一种壳聚糖纤维纱织物的制造方法 |
CN113304302B (zh) * | 2021-05-25 | 2022-10-04 | 南通大学 | 促进高渗出性伤口愈合的防粘连医用敷料及其制备方法 |
CN113384561B (zh) * | 2021-08-11 | 2021-11-30 | 寿光市中医医院 | 一种防过敏的痛经贴及其制备方法 |
KR102445210B1 (ko) * | 2022-02-23 | 2022-09-19 | 김향선 | 수용성 키토산섬유의 제조방법 및 이를 이용한 키토산부직포의 제조방법 |
CN115726047B (zh) | 2022-11-03 | 2023-07-28 | 温州佳远生物科技有限公司 | 一种纯壳聚糖纤维的制备方法 |
WO2024123259A1 (en) * | 2022-12-05 | 2024-06-13 | Fikrettin Sahin | New polymer-based hemostatic formulations provided with anti microbial, anti-viral and anti-inflammatory properties and production method thereof |
CN115814149A (zh) * | 2022-12-30 | 2023-03-21 | 东华大学 | 一种改性羧甲基壳聚糖止血材料及其制备方法 |
CN116355553B (zh) * | 2023-02-22 | 2024-05-28 | 武汉理工大学 | 一种烟草薄片胶粘剂及其制备方法和在制备烟草薄片中的应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4619995A (en) * | 1984-12-24 | 1986-10-28 | Nova Chem Limited | N,O-carboxymethyl chitosan and preparative method therefor |
US5460939A (en) * | 1986-04-18 | 1995-10-24 | Advanced Tissue Sciences, Inc. | Temporary living skin replacement |
US20040166307A1 (en) * | 2001-08-24 | 2004-08-26 | The Procter & Gamble Company | Absorbent member with improved fluid handling agent |
CN1308510C (zh) * | 2004-07-02 | 2007-04-04 | 秦益民 | 羧甲基甲壳胺纤维及制备方法和应用 |
CN1833731A (zh) * | 2005-03-17 | 2006-09-20 | 李毅彬 | 一种抗菌医用敷料的制造方法及其用途 |
CN1833732A (zh) * | 2005-03-17 | 2006-09-20 | 李毅彬 | 一种抗菌医用敷料的制造方法及其用途 |
CN2824888Y (zh) * | 2005-05-13 | 2006-10-11 | 褚省吾 | 一种超强吸收的海藻酸钙止血敷料 |
CN1920129A (zh) * | 2006-09-20 | 2007-02-28 | 天津工业大学 | 一种羟乙基壳聚糖改性粘胶纤维及其制造方法 |
CN101049513B (zh) * | 2007-05-13 | 2010-05-19 | 刘万顺 | 水溶性壳聚糖基纤维止血愈创材料及其制备方法和应用 |
CN101053669B (zh) * | 2007-05-22 | 2010-05-26 | 中国海洋大学 | 一种水溶性壳聚糖基止血愈创海绵及其制备方法和应用 |
-
2007
- 2007-05-13 CN CN200710015743A patent/CN101049513B/zh active Active
-
2008
- 2008-03-31 WO PCT/CN2008/000636 patent/WO2008138202A1/zh active Application Filing
- 2008-03-31 EP EP08715072.8A patent/EP2156849B1/en active Active
- 2008-03-31 US US12/599,769 patent/US20100305489A1/en not_active Abandoned
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008138202A1 (en) * | 2007-05-13 | 2008-11-20 | Qingdao Biotemed Biomaterial Co., Ltd | A chitosan based fiber material, preparing method and application thereof |
CN102218154A (zh) * | 2010-04-15 | 2011-10-19 | 郑明义 | 羧甲基羟乙基改性棉纤维止血织物及其制备方法 |
CN102371003A (zh) * | 2010-08-18 | 2012-03-14 | 张德华 | 水溶性纤维织物创面敷料及其制备方法 |
TWI477670B (zh) * | 2011-01-06 | 2015-03-21 | Taiwan Textile Res Inst | 微米級纖維狀止血材料及其製備方法 |
CN102373620B (zh) * | 2011-11-11 | 2013-04-17 | 武汉纺织大学 | 一种羟丙基三甲基氯化铵甲壳胺纤维的制备方法 |
CN102373620A (zh) * | 2011-11-11 | 2012-03-14 | 武汉纺织大学 | 一种羟丙基三甲基氯化铵甲壳胺纤维的制备方法 |
US10759877B2 (en) | 2012-08-17 | 2020-09-01 | The University Of North Carolina At Chapel Hill | Water soluble nitric oxide-releasing polyglucosamines and uses thereof |
CN104755505A (zh) * | 2012-08-17 | 2015-07-01 | 北卡罗来纳大学查珀尔希尔分校 | 水溶性的释放一氧化氮的聚葡糖胺和其用途 |
CN106986952A (zh) * | 2012-08-17 | 2017-07-28 | 北卡罗来纳大学查珀尔希尔分校 | 水溶性的释放一氧化氮的聚葡糖胺和其用途 |
CN103143050A (zh) * | 2013-03-08 | 2013-06-12 | 苏州艾美医疗用品有限公司 | 羧甲基壳聚糖创可贴及其制备方法 |
CN105568675A (zh) * | 2014-10-14 | 2016-05-11 | 中国海洋大学 | 一种h型羧甲基壳聚糖纤维的制备方法 |
CN105568675B (zh) * | 2014-10-14 | 2018-04-20 | 中国海洋大学 | 一种h型羧甲基壳聚糖纤维的制备方法 |
CN106267305A (zh) * | 2016-08-08 | 2017-01-04 | 江苏诺瓦立医疗用品有限公司 | 止血材料 |
US11072668B2 (en) | 2017-01-03 | 2021-07-27 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto |
US11697693B2 (en) | 2017-01-03 | 2023-07-11 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto |
US11723914B2 (en) | 2017-03-28 | 2023-08-15 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing polyaminoglycosides as biodegradable antibacterial scaffolds and methods pertaining thereto |
CN110770373A (zh) * | 2017-06-27 | 2020-02-07 | 科德宝两合公司 | 形成水凝胶的多组分纤维 |
CN107724074A (zh) * | 2017-07-31 | 2018-02-23 | 山东人文置业有限公司 | 一种水溶性壳聚糖纤维的制备方法 |
CN107875433A (zh) * | 2017-11-30 | 2018-04-06 | 英泰时尚服饰(苏州)有限公司 | 一种快速止血型针织布的制备方法 |
US11672818B2 (en) | 2018-03-06 | 2023-06-13 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto |
US11026965B2 (en) | 2018-03-06 | 2021-06-08 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto |
US11421044B2 (en) | 2018-12-28 | 2022-08-23 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto |
CN113117132A (zh) * | 2019-12-31 | 2021-07-16 | 广州迈普再生医学科技股份有限公司 | 一种可吸收膨胀式纳米短纤维粉状材料及其制备方法和应用 |
CN113117132B (zh) * | 2019-12-31 | 2022-11-22 | 广州迈普再生医学科技股份有限公司 | 一种可吸收膨胀式纳米短纤维粉状材料及其制备方法和应用 |
CN111450304A (zh) * | 2020-03-17 | 2020-07-28 | 青岛博益特生物材料股份有限公司 | 一种带正电荷生物纤维止血抑菌材料及其制备方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
CN101049513B (zh) | 2010-05-19 |
EP2156849B1 (en) | 2017-10-25 |
US20100305489A1 (en) | 2010-12-02 |
EP2156849A1 (en) | 2010-02-24 |
EP2156849A4 (en) | 2010-08-18 |
WO2008138202A1 (en) | 2008-11-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101049513B (zh) | 水溶性壳聚糖基纤维止血愈创材料及其制备方法和应用 | |
CN101053669B (zh) | 一种水溶性壳聚糖基止血愈创海绵及其制备方法和应用 | |
CN102600013B (zh) | 一种医用植绒止血材料及其制备和应用 | |
CN101654537B (zh) | 一种羧甲基壳聚糖/聚乙烯醇复合海绵及其制备方法 | |
CN107130333B (zh) | 一种海藻酸与壳聚糖混编纤维及其制备方法 | |
KR20150013281A (ko) | 다당류 섬유의 제조 방법, 이를 포함하는 상처 피복재, 상처 피복재의 제조 방법, 및 다당류 섬유의 제조 장치 | |
CN104623718B (zh) | 壳聚糖凡士林纱布及其制备方法 | |
EP2764146B1 (en) | Polysaccharide fibres for wound dressings | |
CN107551312B (zh) | 一种絮状胶原止血纤维及其制备方法 | |
CN109224116A (zh) | 一种高吸收性的抗菌止血医用敷料及制备方法 | |
CN114404648A (zh) | 促进糖尿病创面修复可降解抗菌止血水凝胶的制备方法 | |
CN109453411A (zh) | 一种壳聚糖敷料 | |
CN101597381A (zh) | 一种用于针后贴的海藻酸钙复合膜医用敷料及其制备方法和应用 | |
CN106975098B (zh) | 一种复合多糖止血组合物及其制备方法与应用 | |
CN106693038A (zh) | 一种抗菌止血医用海绵的制备方法 | |
CN112206342A (zh) | 一种藻酸盐复合敷料及其制备方法 | |
CN1212162C (zh) | 一种人工皮肤的制备方法 | |
CN103174017B (zh) | 一种氧化海藻酸钠改性的甲壳胺纤维及其制备方法和应用 | |
CN108721706A (zh) | 一种可拉伸生物医用膜的制备方法 | |
CN104744723B (zh) | 壳聚糖医用材料及其制备方法和用途 | |
JP4875804B2 (ja) | 止血材 | |
CN109330662B (zh) | 一种止血纱布结构 | |
CN109432491B (zh) | 一种缓释性止血纱布 | |
Liu et al. | Corn stalk modified chitin composite sponge for effective hemostasis and promoting wound healing | |
CN109395148B (zh) | 一种可吸收止血纱 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: OCEAN UNIVERSITY OF CHINA Free format text: FORMER OWNER: LIU WANSHUN Effective date: 20130418 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 266071 QINGDAO, SHANDONG PROVINCE TO: 266100 QINGDAO, SHANDONG PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20130418 Address after: 266100 Shandong Province, Qingdao city Laoshan District Songling Road No. 238 Patentee after: Ocean University of China Address before: 266071, 202 units, 16 West, 23 East Hongkong Road, Qingdao, Shandong Patentee before: Liu Wanshun |
|
ASS | Succession or assignment of patent right |
Owner name: QINGDAO BOYITE BIOLOGICAL MATERIAL CO., LTD. Free format text: FORMER OWNER: OCEAN UNIVERSITY OF CHINA Effective date: 20130801 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 266100 QINGDAO, SHANDONG PROVINCE TO: 266101 QINGDAO, SHANDONG PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20130801 Address after: 266101 Zhuzhou Road, Laoshan District, Shandong, No. 151, No. Patentee after: Qingdao Boyite Biological Material Co., Ltd. Address before: 266100 Shandong Province, Qingdao city Laoshan District Songling Road No. 238 Patentee before: Ocean University of China |
|
C56 | Change in the name or address of the patentee |
Owner name: QINGDAO BOYITE BIOMATERIAL CO., LTD. Free format text: FORMER NAME: QINGDAO BOYITE BIOLOGICAL MATERIAL CO., LTD. |
|
CP01 | Change in the name or title of a patent holder |
Address after: 266101 Zhuzhou Road, Laoshan District, Shandong, No. 151, No. Patentee after: QINGDAO BIOTEMED BIOLOGICAL MATERIAL CO., LTD. Address before: 266101 Zhuzhou Road, Laoshan District, Shandong, No. 151, No. Patentee before: Qingdao Boyite Biological Material Co., Ltd. |