CN102373620B - 一种羟丙基三甲基氯化铵甲壳胺纤维的制备方法 - Google Patents
一种羟丙基三甲基氯化铵甲壳胺纤维的制备方法 Download PDFInfo
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- CN102373620B CN102373620B CN 201110357387 CN201110357387A CN102373620B CN 102373620 B CN102373620 B CN 102373620B CN 201110357387 CN201110357387 CN 201110357387 CN 201110357387 A CN201110357387 A CN 201110357387A CN 102373620 B CN102373620 B CN 102373620B
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- Prior art keywords
- ammonium chloride
- trimethyl ammonium
- fiber
- chitin fiber
- hydroxypropyl trimethyl
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- 239000000835 fiber Substances 0.000 title claims abstract description 134
- 229920002101 Chitin Polymers 0.000 title claims abstract description 65
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims abstract description 30
- MSWZFWKMSRAUBD-IVMDWMLBSA-N glucosamine group Chemical group OC1[C@H](N)[C@@H](O)[C@H](O)[C@H](O1)CO MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims abstract description 7
- 229920001661 Chitosan Polymers 0.000 claims description 69
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 48
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 30
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 24
- 239000000243 solution Substances 0.000 claims description 20
- 239000007864 aqueous solution Substances 0.000 claims description 17
- 239000003960 organic solvent Substances 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 15
- 238000006467 substitution reaction Methods 0.000 claims description 15
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000003513 alkali Substances 0.000 claims description 8
- 230000018044 dehydration Effects 0.000 claims description 8
- 238000006297 dehydration reaction Methods 0.000 claims description 8
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 8
- 238000005406 washing Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
- 150000007529 inorganic bases Chemical class 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 abstract description 8
- 239000007788 liquid Substances 0.000 abstract description 8
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 150000003242 quaternary ammonium salts Chemical group 0.000 abstract description 3
- 238000007142 ring opening reaction Methods 0.000 abstract description 3
- 239000002657 fibrous material Substances 0.000 abstract description 2
- PUVAFTRIIUSGLK-UHFFFAOYSA-M trimethyl(oxiran-2-ylmethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CC1CO1 PUVAFTRIIUSGLK-UHFFFAOYSA-M 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003700 epoxy group Chemical group 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 description 13
- 206010052428 Wound Diseases 0.000 description 11
- 208000027418 Wounds and injury Diseases 0.000 description 11
- 239000004745 nonwoven fabric Substances 0.000 description 11
- 238000005303 weighing Methods 0.000 description 8
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000011541 reaction mixture Substances 0.000 description 5
- 238000002791 soaking Methods 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 208000004210 Pressure Ulcer Diseases 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 206010053615 Thermal burn Diseases 0.000 description 3
- 230000002745 absorbent Effects 0.000 description 3
- 239000002250 absorbent Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000005213 imbibition Methods 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 239000004593 Epoxy Substances 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- -1 hydroxyethyl group Chemical group 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000009958 sewing Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
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- Polysaccharides And Polysaccharide Derivatives (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Materials For Medical Uses (AREA)
Abstract
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CN 201110357387 CN102373620B (zh) | 2011-11-11 | 2011-11-11 | 一种羟丙基三甲基氯化铵甲壳胺纤维的制备方法 |
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CN 201110357387 CN102373620B (zh) | 2011-11-11 | 2011-11-11 | 一种羟丙基三甲基氯化铵甲壳胺纤维的制备方法 |
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Families Citing this family (8)
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CN102716509B (zh) * | 2012-06-25 | 2014-06-11 | 武汉纺织大学 | 一种抗菌水胶体及其制备方法 |
CN103397509A (zh) * | 2013-08-07 | 2013-11-20 | 武汉纺织大学 | 一种抗菌吸液纱布的制备方法 |
CN104532402A (zh) * | 2014-12-31 | 2015-04-22 | 福建恒安集团有限公司 | 一种多功能超吸水海藻纤维的制备 |
CN105233327A (zh) * | 2015-11-09 | 2016-01-13 | 佛山市优特医疗科技有限公司 | 一种季铵化壳聚糖纤维及吸湿抗菌伤口敷料 |
CN111450304A (zh) * | 2020-03-17 | 2020-07-28 | 青岛博益特生物材料股份有限公司 | 一种带正电荷生物纤维止血抑菌材料及其制备方法和应用 |
CN111388374B (zh) * | 2020-04-11 | 2022-09-06 | 百草堂(湖北)制药有限公司 | 一种洗发露 |
CN112851834B (zh) * | 2021-01-08 | 2022-03-18 | 西南石油大学 | 一种抗温琼脂的制备方法及应用 |
CN114128658B (zh) * | 2021-11-25 | 2023-03-24 | 中国水产科学研究院黑龙江水产研究所 | 一种用于人工鱼巢的改性椰丝材料的制备方法 |
Citations (3)
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CN101049513A (zh) * | 2007-05-13 | 2007-10-10 | 刘万顺 | 水溶性壳聚糖基纤维止血愈创材料及其制备方法和应用 |
CN101343334A (zh) * | 2008-07-16 | 2009-01-14 | 深圳大学 | O-2′-羟丙基三甲基氯化铵壳聚糖的制备方法 |
CN101368328A (zh) * | 2008-08-04 | 2009-02-18 | 东华大学 | 一种羟乙基壳聚糖纤维的制备方法 |
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JPH11247067A (ja) * | 1998-02-27 | 1999-09-14 | Fuji Spinning Co Ltd | ポリエステル系合成繊維製品の親水化加工方法 |
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CN101049513A (zh) * | 2007-05-13 | 2007-10-10 | 刘万顺 | 水溶性壳聚糖基纤维止血愈创材料及其制备方法和应用 |
CN101343334A (zh) * | 2008-07-16 | 2009-01-14 | 深圳大学 | O-2′-羟丙基三甲基氯化铵壳聚糖的制备方法 |
CN101368328A (zh) * | 2008-08-04 | 2009-02-18 | 东华大学 | 一种羟乙基壳聚糖纤维的制备方法 |
Non-Patent Citations (3)
Title |
---|
JP特开平11-247067A 1999.09.14 |
林友文等.羟丙基三甲基氯化铵壳聚糖的制备及其吸湿、保湿性能.《应用化学》.2002,第19卷(第4期),第352-355页. |
羟丙基三甲基氯化铵壳聚糖的制备及其吸湿、保湿性能;林友文等;《应用化学》;20020430;第19卷(第4期);第352-355页 * |
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